CN108144038B

CN108144038B - Traditional Chinese medicine composition for removing chloasma and application thereof

Info

Publication number: CN108144038B
Application number: CN201810239238.8A
Authority: CN
Inventors: 高鹏飞; 张岚; 徐月妹; 潘丹青; 肖茜; 高崎
Original assignee: Jinshan Hospital of Fudan University
Current assignee: Jinshan Hospital of Fudan University
Priority date: 2018-03-22
Filing date: 2018-03-22
Publication date: 2020-12-01
Anticipated expiration: 2038-03-22
Also published as: CN108144038A

Abstract

The invention relates to a traditional Chinese medicine composition for removing chloasma, which is prepared from the following raw material medicines: radix bupleuri, codonopsis pilosula, ligusticum wallichii, white atractylodes rhizome fried with honey bran, Chinese date, scutellaria baicalensis, liquorice, white peony root fried with honey bran, rhizoma alismatis, prepared pinellia ternate, angelica, white poria and rhizoma zingiberis. Its advantages are: the traditional Chinese medicine composition disclosed by the invention is proper in compatibility, and can effectively remove chloasma due to the comprehensive action of the raw medicinal materials. The traditional Chinese medicine composition can obviously improve the SOD activity in blood and skin tissues of chloasma pathological model animals caused by ultraviolet irradiation, reduce the content of MDA, reduce the degree of peroxidation in vivo, and enhance the oxidation resistance and the free radical scavenging capacity.

Description

Traditional Chinese medicine composition for removing chloasma and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for removing chloasma and application thereof.

Background

Chloasma is an acquired pigmentation skin disease, is represented by symmetrical pigmentation skin disease of pigments, is represented by symmetrical pigmentation of pigments, is butterfly wing-shaped, light yellow or light brown, is scattered on two sides of a cheek in a spot sheet shape, is more common on the lower outer side of eyes, is more dark brown or light black, is more common in young women, and is one of the skin diseases which are common clinically and difficult to cure.

Chinese patent document CN107714798A discloses a traditional Chinese medicine composition for treating chloasma: cassia twig, poria cocos, peach kernel, red paeony root, white paeony root, cortex moutan, Chinese angelica, radix bupleuri, bighead atractylodes rhizome, liquorice, mint, rose, safflower and flos mume. Chinese patent document CN104587129A discloses a traditional Chinese medicine for treating chloasma: white peony root, dahurian angelica root, bupleurum root, white atractylodes rhizome, cape jasmine, dried orange peel, Chinese angelica root, safflower, baikal skullcap root, bark of peony root, peach kernel, cyperus tuber and honey-fried licorice root. Chinese patent document CN102370726A discloses a traditional Chinese medicine for treating chloasma: radix bupleuri, poria cocos, radix paeoniae alba, angelica sinensis, bighead atractylodes rhizome, radix salviae miltiorrhizae, safflower, stiff silkworm and radix angelicae. Chinese patent document CN102512644A discloses a traditional Chinese medicine for removing freckles and beautifying: bupleuri radix, Atractylodis rhizoma, rhizoma Zingiberis recens, Saviae Miltiorrhizae radix, semen Persicae, herba Artemisiae Annuae, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, radix Paeoniae alba, fructus Gardeniae preparata, rhizoma Cyperi, cortex moutan, herba Menthae, and stigma croci Sativi. However, the traditional Chinese medicine composition for removing chloasma and the application thereof are not reported at present.

Disclosure of Invention

The first purpose of the invention is to provide a traditional Chinese medicine composition for removing chloasma aiming at the defects in the prior art.

The second purpose of the invention is to provide an application of the traditional Chinese medicine composition.

In order to achieve the first purpose, the invention adopts the technical scheme that: the traditional Chinese medicine composition for removing chloasma is prepared from the following raw material medicines in parts by weight: 10-20 parts of radix bupleuri, 7-13 parts of codonopsis pilosula, 4-8 parts of ligusticum wallichii, 10-20 parts of honey bran-fried bighead atractylodes rhizome, 20-40 parts of Chinese date, 6-12 parts of scutellaria baicalensis, 2-4 parts of liquorice, 10-20 parts of honey bran-fried white paeony root, 10-20 parts of rhizoma alismatis, 6-12 parts of prepared pinellia ternate, 7-11 parts of angelica sinensis, 10-20 parts of white poria and 4-8 parts of dried ginger.

Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 13-17 parts of radix bupleuri, 9-11 parts of codonopsis pilosula, 5-7 parts of ligusticum wallichii, 13-17 parts of honey bran-fried bighead atractylodes rhizome, 25-35 parts of Chinese date, 8-10 parts of scutellaria baicalensis, 2.5-3.5 parts of liquorice, 13-17 parts of honey bran-fried white paeony root, 13-17 parts of rhizoma alismatis, 8-10 parts of prepared pinellia ternate, 8-10 parts of angelica sinensis, 13-17 parts of white poria and 5-7 parts of dried ginger.

More preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15 parts of radix bupleuri, 10 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 9 parts of scutellaria baicalensis, 3 parts of liquorice, 15 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 9 parts of angelica, 15 parts of white poria and 6 parts of dried ginger.

In order to achieve the second object, the invention adopts the technical scheme that: the traditional Chinese medicine composition is applied to preparing a medicine or a health-care product for removing chloasma.

Preferably, the medicament is an oral medicament.

The invention has the advantages that:

1. the traditional Chinese medicine composition disclosed by the invention is proper in compatibility, and can effectively remove chloasma due to the comprehensive action of the raw medicinal materials.

2. The traditional Chinese medicine composition can obviously improve the SOD activity in blood and skin tissues of chloasma pathological model animals caused by ultraviolet irradiation, reduce the content of MDA, reduce the degree of peroxidation in vivo, and enhance the oxidation resistance and the free radical scavenging capacity.

Detailed Description

The following examples are provided to illustrate specific embodiments of the present invention.

Example 1

15 parts of radix bupleuri, 10 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 9 parts of scutellaria baicalensis, 3 parts of liquorice, 15 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 9 parts of angelica, 15 parts of white poria and 6 parts of dried ginger.

Example 2

13 parts of radix bupleuri, 9 parts of codonopsis pilosula, 5 parts of ligusticum wallichii, 13 parts of honey bran-fried bighead atractylodes rhizome, 25 parts of Chinese date, 8 parts of scutellaria baicalensis, 2.5 parts of liquorice, 13 parts of honey bran-fried white paeony root, 13 parts of rhizoma alismatis, 8 parts of prepared pinellia ternate, 8 parts of angelica sinensis, 13 parts of white poria and 5 parts of dried ginger.

Example 3

13 parts of radix bupleuri, 10 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 25 parts of Chinese date, 9 parts of scutellaria baicalensis, 3 parts of liquorice, 15 parts of honey bran-fried white paeony root, 13 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 9 parts of angelica, 15 parts of white poria and 5 parts of dried ginger.

Example 4

13 parts of radix bupleuri, 11 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 17 parts of honey bran-fried bighead atractylodes rhizome, 25 parts of Chinese date, 10 parts of scutellaria baicalensis, 3.5 parts of liquorice, 17 parts of honey bran-fried white paeony root, 13 parts of rhizoma alismatis, 10 parts of prepared pinellia ternate, 10 parts of angelica sinensis, 17 parts of white poria and 5 parts of dried ginger.

Example 5

15 parts of radix bupleuri, 9 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 17 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 8 parts of scutellaria baicalensis, 3 parts of liquorice, 17 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 8 parts of prepared pinellia ternate, 9 parts of angelica, 17 parts of white poria and 6 parts of dried ginger.

Example 6

15 parts of radix bupleuri, 10 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 13 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 9 parts of scutellaria baicalensis, 3.5 parts of liquorice, 13 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 10 parts of angelica sinensis, 13 parts of white poria and 6 parts of dried ginger.

Example 7

15 parts of radix bupleuri, 11 parts of codonopsis pilosula, 5 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 10 parts of scutellaria baicalensis, 2.5 parts of liquorice, 15 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 10 parts of prepared pinellia ternate, 8 parts of angelica sinensis, 15 parts of white poria and 6 parts of dried ginger.

Example 8

17 parts of radix bupleuri, 9 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 35 parts of Chinese date, 8 parts of scutellaria baicalensis, 3.5 parts of liquorice, 15 parts of honey bran-fried white paeony root, 17 parts of rhizoma alismatis, 8 parts of prepared pinellia ternate, 10 parts of angelica sinensis, 15 parts of white poria and 7 parts of dried ginger.

Example 9

17 parts of radix bupleuri, 10 parts of codonopsis pilosula, 5 parts of ligusticum wallichii, 17 parts of honey bran-fried bighead atractylodes rhizome, 35 parts of Chinese date, 9 parts of scutellaria baicalensis, 2.5 parts of liquorice, 17 parts of honey bran-fried white paeony root, 17 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 8 parts of angelica sinensis, 17 parts of white poria and 7 parts of dried ginger.

Example 10

17 parts of radix bupleuri, 11 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 13 parts of honey bran-fried bighead atractylodes rhizome, 35 parts of Chinese date, 10 parts of scutellaria baicalensis, 3 parts of liquorice, 13 parts of honey bran-fried white paeony root, 17 parts of rhizoma alismatis, 10 parts of prepared pinellia ternate, 9 parts of angelica, 13 parts of white poria and 7 parts of dried ginger.

Example 11

10 parts of radix bupleuri, 7 parts of codonopsis pilosula, 4 parts of ligusticum wallichii, 10 parts of honey bran-fried bighead atractylodes rhizome, 20 parts of Chinese date, 6 parts of scutellaria baicalensis, 2 parts of liquorice, 10 parts of honey bran-fried white paeony root, 10 parts of rhizoma alismatis, 6 parts of prepared pinellia ternate, 6 parts of angelica, 10 parts of white poria and 4 parts of dried ginger.

Example 12

10 parts of radix bupleuri, 10 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 20 parts of Chinese date, 9 parts of scutellaria baicalensis, 3 parts of liquorice, 15 parts of honey bran-fried white paeony root, 10 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 9 parts of angelica, 15 parts of white poria and 4 parts of dried ginger.

Example 13

10 parts of radix bupleuri, 13 parts of codonopsis pilosula, 8 parts of ligusticum wallichii, 20 parts of honey bran-fried bighead atractylodes rhizome, 20 parts of Chinese date, 12 parts of scutellaria baicalensis, 4 parts of liquorice, 20 parts of honey bran-fried white paeony root, 10 parts of rhizoma alismatis, 12 parts of prepared pinellia ternate, 12 parts of angelica, 20 parts of white poria and 4 parts of dried ginger.

Example 14

15 parts of radix bupleuri, 7 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 20 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 6 parts of scutellaria baicalensis, 3 parts of liquorice, 20 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 6 parts of prepared pinellia ternate, 9 parts of angelica, 20 parts of white poria and 6 parts of dried ginger.

Example 15

15 parts of radix bupleuri, 10 parts of codonopsis pilosula, 8 parts of ligusticum wallichii, 10 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 9 parts of scutellaria baicalensis, 4 parts of liquorice, 10 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 12 parts of angelica, 10 parts of white poria and 6 parts of dried ginger.

Example 16

15 parts of radix bupleuri, 13 parts of codonopsis pilosula, 4 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 12 parts of scutellaria baicalensis, 2 parts of liquorice, 15 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 12 parts of prepared pinellia ternate, 6 parts of angelica, 15 parts of white poria and 6 parts of dried ginger.

Example 17

20 parts of radix bupleuri, 7 parts of codonopsis pilosula, 8 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 40 parts of Chinese date, 6 parts of scutellaria baicalensis, 4 parts of liquorice, 15 parts of honey bran-fried white paeony root, 20 parts of rhizoma alismatis, 6 parts of prepared pinellia ternate, 12 parts of angelica, 15 parts of white poria and 8 parts of dried ginger.

Example 18

20 parts of radix bupleuri, 10 parts of codonopsis pilosula, 4 parts of ligusticum wallichii, 20 parts of honey bran-fried bighead atractylodes rhizome, 40 parts of Chinese date, 9 parts of scutellaria baicalensis, 2 parts of liquorice, 20 parts of honey bran-fried white paeony root, 20 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 6 parts of angelica, 20 parts of white poria and 8 parts of dried ginger.

Example 19

20 parts of radix bupleuri, 13 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 10 parts of honey bran-fried bighead atractylodes rhizome, 40 parts of Chinese date, 12 parts of scutellaria baicalensis, 3 parts of liquorice, 10 parts of honey bran-fried white paeony root, 20 parts of rhizoma alismatis, 12 parts of prepared pinellia ternate, 9 parts of angelica, 10 parts of white poria and 8 parts of dried ginger.

Comparative example 1

6 parts of ligusticum wallichii, 15 parts of rhizoma atractylodis macrocephalae stir-fried with honey bran, 15 parts of white paeony root stir-fried with honey bran, 15 parts of rhizoma alismatis, 9 parts of angelica and 15 parts of white poria.

Comparative example 2

15 parts of radix bupleuri, 10 parts of codonopsis pilosula, 30 parts of Chinese date, 9 parts of scutellaria baicalensis, 3 parts of liquorice, 9 parts of prepared pinellia ternate and 6 parts of dried ginger.

Comparative example 3

10 parts of radix bupleuri, 10 parts of codonopsis pilosula, 10 parts of ligusticum wallichii, 10 parts of honey bran-fried bighead atractylodes rhizome, 10 parts of Chinese date, 10 parts of scutellaria baicalensis, 10 parts of liquorice, 10 parts of honey bran-fried white paeony root, 10 parts of rhizoma alismatis, 10 parts of prepared pinellia ternate, 10 parts of angelica, 10 parts of white poria and 10 parts of dried ginger.

EXAMPLE 20 clinical trial

1 clinical data

1.1 diagnostic criteria

Meets the clinical diagnosis standard of chloasma specified by the skin disease committee of the Chinese traditional and western medicine integration society.

1.2 inclusion criteria

(1) The diagnostic standard is met;

(2) age 18-45 years;

(3) no pigmentation caused by other skin diseases or other diseases;

(4) patients agreed to the study treatment protocol and signed informed consent.

1.3 exclusion criteria

(1) Other skin diseases such as vitiligo, psoriasis, lupus erythematosus;

(2) serious dysfunction of heart, liver, kidney and other important organs;

(3) combined with diabetes, tumor, myocardial infarction, etc.;

(4) gestation or lactation;

(5) there is a history of recent (4 weeks) treatment with drugs such as glucocorticoids, immunosuppressants, etc.

1.4 general data

160 female chloasma patients diagnosed and treated in the hospital all meet the standard.

The patients are randomly divided into 4 groups according to a random parallel grouping method, and the differences of the ages, the disease courses and the like of the 4 groups of patients have no statistical significance (P is more than 0.05) and are comparable.

1.5 methods of treatment

All 4 groups of patients are subjected to psychological intervention to help the patients to establish correct treatment views and disease views, relieve psychological pressure, eliminate bad emotions, formulate scientific and effective diet, life and exercise intervention plans, reduce endocrine dyscrasia caused by irregular life habits, guide self-regulation methods of the patients and finally achieve the purpose of physical and mental relaxation.

Group A: the Chinese medicinal composition of example 1 was administered by decocting in water and administered twice a day in the morning and at night, 1 dose/day.

Group B: the composition of comparative example 1 was administered by decocting in water twice a day in the morning and evening at 1 dose/day.

Group C: the composition of comparative example 2 was administered by decocting in water twice a day in the morning and at night, 1 dose/day.

Group D: vitamin C is given at 300mg per day orally, 3 times per day, natural vitamin E is given at 100mg per day orally, 3 times per day.

The above 4 groups of patients are treated continuously for 8 weeks to form 1 course of treatment, and the curative effect is judged after the course of treatment is finished.

1.6 evaluation index

1.6.1 mottle area and mottle score

(1) Area of color spot: the areas of the color spots are sequentially marked as 3 points (the area of the color spots is more than 4 cm)²) 2 points (area of color spots 2-4 cm)²) 1 point (area of color spot < 2 cm)²) 0 point (no mottle);

(2) spot color scoring: the color of the color spots is recorded as 3 points (dark brown), 2 points (brown), 1 point (light brown) and 0 point (normal skin color) in sequence according to the depth.

1.6.2 therapeutic efficacy assessment criteria

Basically curing: the fading area of the facial color spots is more than or equal to 90 percent, the color spots basically disappear, and other accompanying symptoms are obviously improved;

the effect is shown: the area of the facial color spot is faded to be more than or equal to 60 percent but less than 90 percent, the color of the facial color spot is obviously lightened, and other accompanying symptoms are improved;

the method has the following advantages: the area of the facial color spot is faded to be more than or equal to 30 percent but less than 60 percent, the color of the spot becomes light, and other accompanying symptoms are improved or not changed;

and (4) invalidation: the area of the facial color spot is reduced by less than 30 percent, the color of the spot is basically not improved or even aggravated, and other accompanying symptoms are not improved.

2 results

2.1 comparison of mottle area and mottle score

The comparison of the spot size and spot color score before and after treatment in the 4 groups is shown in tables 1 and 2.

TABLE 1 comparison of the areas of the color spots (cm)²)

TABLE 2 comparison of Spot color scores

2.2 comparison of clinical efficacy

The results of comparison of clinical efficacy before and after treatment for 4 groups of patients are shown in Table 3.

TABLE 3 comparison of clinical efficacy

Example 21 animal testing

1 Material

The weight of a common-grade Kunming female mouse is 18-22 g.

2 method

2.1 grouping of Experimental animals

The mice were randomly divided into 9 groups of 10 mice each.

Group A: normal control group, 0.5 ml/day/time/body of physiological saline

Group B: model control group, 0.5 ml/day/time/body of physiological saline

Group C: comparative example 1 the Chinese medicinal composition is prepared into decoction, 0.5 ml/day/time/dose, and the dosage is 11g/kg of Chinese medicinal materials.

Group D: comparative example 2 the Chinese medicinal composition is prepared into decoction, 0.5 ml/day/time/dose, and the dosage is 11g/kg of Chinese medicinal materials.

Group E: comparative example 3 the Chinese medicinal composition is prepared into decoction, 0.5 ml/day/time/dose, and the dosage is 11g/kg of Chinese medicinal materials.

And F group: example 1 the Chinese medicinal composition is prepared into decoction, 0.5 ml/day/time/dose, and the dosage is 11g/kg of Chinese medicinal materials.

Group G: example 6 the Chinese medicinal composition is prepared into decoction, 0.5 ml/day/time/dose, and the dosage is 11g/kg of Chinese medicinal materials.

Group H: example 15 the Chinese medicinal composition is prepared into decoction, 0.5 ml/day/time/dose, and the dosage is 11g/kg of Chinese medicinal materials.

Group I: western medicine control group, vitamin C pill, grinding into powder, and dissolving in 0.5ml distilled water

The administration mode is intragastric administration, and the administration treatment time is 4 weeks.

2.2 animal model creation

The back of each group of experimental mice had been depilated with an exposed area of about 2cm x 2cm, 1 time per week. Except for the normal control group, each group of experimental animals irradiated the mice with medium-wave ultraviolet rays with a wavelength of 320nm for about 20 minutes 1 time per day, and the distance between the animal and the light source was 20 cm. Irradiation was continued for 4 weeks.

2.3 index determination

2.3.1 obtaining materials

At the end of 8 weeks of the experiment, the experimental mice had their backs depilated with an instrument and had an area of about 2cm by 2 cm.

(1) Blood sampling: blood is taken by an eyeball taking method, and about 3-5 ml of blood is taken; and (3) labeling the test tube, centrifuging by using a centrifuge at 3000-4000 rpm, taking serum, and detecting the SOD and the MDA of the serum according to the instruction steps of the kit specification.

(2) Taking the skin: after all the experimental mice taking blood die at the neck-broken positions, the whole skin (without subcutaneous fat) at the back depilated positions is immediately taken down and frozen in a refrigerator at the temperature of 70 ℃ below zero for storage and testing.

2.3.2 preparation of skin homogenate

(1) Each mouse skin tissue specimen was 0.5g, rinsed in ice physiological saline, blood removed, wiped with filter paper, and the tissue mass was cut as much as possible with small ophthalmic scissors and poured into a glass homogenizer tube.

(2) 4.5ml of cold physiological saline is measured by a measuring cylinder and poured into a homogenizer for sufficient homogenization.

(3) The slurry was centrifuged at 4000rpm for 10 minutes.

(4) Taking supernatant, and carrying out index determination according to the operation of the SOD kit and the MDA kit strictly according to the instruction.

3 results

3.1 the results of the effects of SOD activity on the skin and serum of each group of mice are shown in Table 4.

TABLE 4 Effect of SOD Activity in skin and serum

3.2 Effect of MDA content in skin and serum of mice in each group the results are shown in Table 5.

TABLE 5 Effect of MDA content in skin and serum

EXAMPLE 22 decoction

The Chinese medicinal composition of examples 1 to 19 is decocted in water to obtain a decoction.

EXAMPLE 23 granules

The traditional Chinese medicine composition of the embodiment 1-19 is decocted for 3 times by adding water, the filtrates are combined and concentrated to a clear paste with the relative density of 1.1. Adding ethanol into the fluid extract, standing for 24 hours, filtering, recovering ethanol, and concentrating to obtain a thick paste with a relative density of 1.2. Spray drying the soft extract to obtain dry extract fine powder. Adding dextrin into the dry extract fine powder, mixing, granulating by conventional method, drying, and making into granule.

EXAMPLE 24 dispersible tablets

The traditional Chinese medicine composition of the embodiment 1-19 is decocted for 3 times by adding water, the filtrates are combined and concentrated to a clear paste with the relative density of 1.1. Spray drying the fluid extract to obtain dry extract fine powder. Mixing the dry extract fine powder with sodium carboxymethyl starch and microcrystalline cellulose, granulating by conventional method, drying, adding magnesium stearate and silicon dioxide, mixing, tabletting by conventional method, and making into dispersible tablet.

EXAMPLE 25 Capsule

The traditional Chinese medicine composition of the embodiment 1-19 is decocted for 3 times by adding water, the filtrates are combined and concentrated to obtain clear paste with the relative density of 1.15. Spray drying the fluid extract to obtain dry extract fine powder. Adding magnesium stearate and pulvis Talci, mixing, adding hollow capsule by conventional method, and making into capsule.

EXAMPLE 26 pellets

The traditional Chinese medicine composition of the embodiment 1-19 is decocted for 3 times by adding water, the filtrates are combined and concentrated to obtain clear paste with the relative density of 1.18. Spray drying the fluid extract to obtain fine powder. Adding appropriate amount of water or/and yellow wine, and making into watered pill. Or adding appropriate amount of ethanol and soybean oil to make soft mass, making into pill with pellet making machine, drying, sieving, and making into pellet. Or making dripping pill with polyethylene glycol as matrix and dimethyl silicone oil as condensate.

Example 27 oral liquid

The traditional Chinese medicine composition of the embodiment 1-19 is decocted for 3 times by adding water, the filtrates are combined and concentrated to a clear paste with the relative density of 1.1. Adding ethanol into the fluid extract, standing for 24 hours, filtering, recovering ethanol, and concentrating to obtain a thick paste with a relative density of 1.2. Dissolving stevioside in pure water by conventional method, adding sodium benzoate and purified water, mixing with the soft extract, and making into oral liquid.

EXAMPLE 28 powder preparation

The Chinese medicinal composition of examples 1 to 19 is pulverized into fine powder by a pulverizer. Sieving, and mixing the fine powder in a mixer to obtain powder.

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition for removing chloasma is characterized by being prepared from the following raw material medicines in parts by weight: 10-20 parts of radix bupleuri, 7-13 parts of codonopsis pilosula, 4-8 parts of ligusticum wallichii, 10-20 parts of honey bran-fried bighead atractylodes rhizome, 20-40 parts of Chinese date, 6-12 parts of scutellaria baicalensis, 2-4 parts of liquorice, 10-20 parts of honey bran-fried white paeony root, 10-20 parts of rhizoma alismatis, 6-12 parts of prepared pinellia ternate, 7-11 parts of angelica sinensis, 10-20 parts of white poria and 4-8 parts of dried ginger.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 13-17 parts of radix bupleuri, 9-11 parts of codonopsis pilosula, 5-7 parts of ligusticum wallichii, 13-17 parts of honey bran-fried bighead atractylodes rhizome, 25-35 parts of Chinese date, 8-10 parts of scutellaria baicalensis, 2.5-3.5 parts of liquorice, 13-17 parts of honey bran-fried white paeony root, 13-17 parts of rhizoma alismatis, 8-10 parts of prepared pinellia ternate, 8-10 parts of angelica sinensis, 13-17 parts of white poria and 5-7 parts of dried ginger.

3. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 15 parts of radix bupleuri, 10 parts of codonopsis pilosula, 6 parts of ligusticum wallichii, 15 parts of honey bran-fried bighead atractylodes rhizome, 30 parts of Chinese date, 9 parts of scutellaria baicalensis, 3 parts of liquorice, 15 parts of honey bran-fried white paeony root, 15 parts of rhizoma alismatis, 9 parts of prepared pinellia ternate, 9 parts of angelica, 15 parts of white poria and 6 parts of dried ginger.

4. The use of the Chinese medicinal composition according to any one of claims 1 to 3 in the preparation of a medicament or health-care product for removing chloasma.

5. The use of claim 4, wherein the medicament is an oral medicament.