CN104958664A - Preparation technology of gynecological disease treatment oral preparation - Google Patents

Abstract

The invention discloses a preparation technology of a gynecological disease treatment oral preparation. The preparation technology of the oral preparation comprises the following steps: adding water to Radix Astragali, stir-baked cortex eucommiae with salt solution, prepared rehmannia root, Himalayan Teasel Root, Gentiana macrophylla, Cistanche deserticola, Achyranthes bidentata and cortex lycii, decocting, filtering the above obtained decoction, and concentrating the above obtained filtrate; taking donkey-hide gelatin, adding water, melting by heat, mixing the melted donkey-hide gelatin with the above obtained concentrate, and concentrating to obtain an extract paste; crushing other medicines to form fine powders, sieving, and uniformly mixing the powders; and uniformly mixing the obtained powder mixture with the extract paste, and processing through a routine technology to prepare the oral preparation. Effective components in lotus leaf in the oral preparation can be easily measured, and drug effects of the gynecological disease treatment oral preparation are effectively improved in order to achieve purposes of the invention.

Description

The processing technology of Zaizao oral formulations

Technical field

The invention belongs to the field of Chinese medicines, be specifically related to a kind of processing technology of Zaizao oral formulations.

Background technology

Chinese medicine processing is a kind of method conventional in herbal pharmaceutical, different medicines, and the method for the process of preparing Chinese medicine is different, and the effect reached after the process of preparing Chinese medicine is different; The object of current process of preparing Chinese medicine medicine is mainly reflected in: the toxic and side effects 1, reducing or eliminate medicine, ensures drug safety; 2, strengthen the effect of medicine, improve clinical efficacy; 3, change performance or effect of medicine, make it the needs that more can adapt to the state of an illness; 4, change some character of medicine, be convenient to storage and preparation; 5, remove impurity and non-medicinal effects, make medical material pure, ensure medical material quanlity and consumption accurate; 6, smelly, taste masking is rectified, so that take.

FUKE ZAIZAO WAN is the famous gynopathic medicine for the treatment of, is made up of, has nourishing blood for regulating menstruation, liver and kidney tonifying 42 taste authentic medicinal herbses, effect of warm palace pain relieving, and for menstruation irregularly, menostaxis, dripping hemorrhage, dysmenorrhea, is with inferior disease successively.

In prior art, Folium Nelumbinis generally adopts charcoal to concoct, and does not have the record of vinegar Folium Nelumbinis (processed).And FUKE ZAIZAO WAN raw materials used in, Folium Nelumbinis adopt vinegar system.The lotus leaf vinegar method that manufacturer originally adopted is: get clean Folium Nelumbinis, fries to surface coke black, spray vinegar, fried dry according to stir-fry carbon method.Every 100kg Folium Artemisiae Argyi, uses vinegar 10kg.But inventor finds in research process, the Folium Nelumbinis adopting described processing procedure to make, in the Zaizao preparation made, the effective ingredient of Folium Nelumbinis is not easily measured.

Summary of the invention

The invention provides a kind of processing technology of Zaizao oral formulations, especially wherein the concocting method of Folium Nelumbinis, its concrete technology parameter is improved, the effective ingredient of Folium Nelumbinis is easily measured, and the effective ingredient of the Folium Nelumbinis measured is high.Effectively can improve the drug effect of Zaizao oral formulations.

To achieve these goals, the invention provides following technical scheme:

Described Zaizao oral formulations, according to listed as parts by weight, is made up of following composition: Radix Angelicae Sinensis (processed with wine) 60-70 part, Rhizoma Cyperi (processed with vinegar) 60-70 part, Radix Paeoniae Alba 40-50 part, Radix Rehmanniae Preparata 15-30 part, Colla Corii Asini 5-20 part, Poria 60-70 part, Radix Codonopsis 15-30 part, Radix Astragali 15-30 part, Rhizoma Dioscoreae 25-40 part, Rhizoma Atractylodis Macrocephalae 10-20 part, (wine steaming) Fructus Ligustri Lucidi 40-50 part, Carapax Et Plastrum Testudinis (processed with vinegar) 25-40 part, Fructus Corni 15-30 part, Radix Dipsaci 15-30 part, Cortex Eucommiae(processed with salt) 15-30 part, Herba Cistanches 5-20 part, Fructus Rubi 10-20 part, Cornu Cervi Degelatinatum 2-10 part, Rhizoma Chuanxiong 40-50 part, Radix Salviae Miltiorrhizae 15-30 part, Radix Achyranthis Bidentatae 10-20 part, Herba Leonuri 15-30 part, Rhizoma Corydalis 10-20 part, Radix Notoginseng (short) 2-10 part, Folium Artemisiae Argyi (processed with vinegar) 40-50 part, Fructus Foeniculi 15-30 part, Rhizoma Ligustici 15-30 part, Endoconcha Sepiae 25-40 part, Radix Sanguisorbae (wine is processed) 25-40 part, Fructus Alpiniae Oxyphyllae 5-20 part, Rhizoma Alismatis 15-30 part, Folium Nelumbinis (processed with vinegar) 10-20 part, Radix Gentianae Macrophyllae 15-30 part, Cortex Lycii 15-30 part, Radix Cynanchi Atrati 40-50 part, Cortex Ailanthi 25-40 part, succinum 2-10 part, Radix Scutellariae (processed with wine) 25-40 part, Semen Ziziphi Spinosae 5-20 part, Radix Polygalae (processed) 10-20 part, Pericarpium Citri Reticulatae 25-40 part, Radix Glycyrrhizae 15-30 part.

Specifically, described Zaizao oral formulations, according to listed as parts by weight, is made up of following composition: Radix Angelicae Sinensis (processed with wine) 65.14 parts, Rhizoma Cyperi (processed with vinegar) 65.14 parts, the Radix Paeoniae Alba 43.43 parts, Radix Rehmanniae Preparata 21.71 parts, 10.86 parts, Colla Corii Asini, 65.14 parts, Poria, Radix Codonopsis 21.71 parts, the Radix Astragali 21.71 parts, Rhizoma Dioscoreae 32.57 parts, the Rhizoma Atractylodis Macrocephalae 16.28 parts, wine Fructus Ligustri Lucidi 43.43 parts, Carapax Et Plastrum Testudinis (processed with vinegar) 32.57 parts, Fructus Corni 21.71 parts, Radix Dipsaci 21.71 parts, Cortex Eucommiae(processed with salt) 21.71 parts, Herba Cistanches 10.86 parts, Fructus Rubi 16.28 parts, Cornu Cervi Degelatinatum 5.43 parts, Rhizoma Chuanxiong 43.43 parts, Radix Salviae Miltiorrhizae 21.71 parts, Radix Achyranthis Bidentatae 16.28 parts, Herba Leonuri 21.71 parts, Rhizoma Corydalis 16.28 parts, Radix Notoginseng (short) 5.43 parts, Folium Artemisiae Argyi (processed with vinegar) 43.43 parts, Fructus Foeniculi 21.71 parts, Rhizoma Ligustici 21.71 parts, Endoconcha Sepiae 32.57 parts, Radix Sanguisorbae (wine is processed) 32.57 parts, Fructus Alpiniae Oxyphyllae 10.86 parts, Rhizoma Alismatis 21.71 parts, 16.28 parts, Folium Nelumbinis (processed with vinegar), Radix Gentianae Macrophyllae 21.71 parts, Cortex Lycii 21.71 parts, Radix Cynanchi Atrati 43.43 parts, Cortex Ailanthi 32.57 parts, succinum 5.43 parts, Radix Scutellariae (processed with wine) 32.57 parts, Semen Ziziphi Spinosae 10.86 parts, Radix Polygalae (processed) 16.28 parts, Pericarpium Citri Reticulatae 32.57 parts and 21.71 parts, Radix Glycyrrhizae.

The processing technology of described oral formulations is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water, and decocting liquid filters, and filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, be condensed into extractum; Then all the other medicines are ground into fine powder, sieve, mixing; Mix with above-mentioned extractum, conveniently technique makes oral formulations.

Specifically, the processing technology of described oral formulations is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water 2 times, each 2 hours, collecting decoction, filters, and filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, when being concentrated into 80 DEG C, relative density is the extractum of 1.10; Then all the other medicines are ground into fine powder, sieve, mixing; Mix with above-mentioned extractum, conveniently technique makes oral formulations.

In described oral formulations, the concocting method of processed with vinegar Folium Nelumbinis is:

Step one: washing: washing is carried out to Folium Nelumbinis, dries;

Step 2: vinegar liquid moistening: get Folium Nelumbinis and put in demulcen container, spray vinegar by the method for spray, sprinkling limit, limit is stirred until stir, and then moistening is exhausted by Folium Nelumbinis medical material to vinegar liquid for 15 ~ 25 minutes completely;

Step 3: fry medicine: Folium Nelumbinis complete for moistening to be put in medicine roasting machine with slow fire heating, fry to become from celadon yellowish green color slightly dry time, taking-up cools;

Step 4: dry: put in clean drip pan by the Folium Nelumbinis through parch, put into drying room drying 85 ~ 105 hours, every 12 hours of period turned over medicine once.

In the processing technology of aforementioned Zaizao oral formulations, in described step 2, the weight ratio of Folium Nelumbinis and vinegar is 100:20.

In the processing technology of aforementioned Zaizao oral formulations, in described step 2, the moistening time is 20 minutes.

In the processing technology of aforementioned Zaizao oral formulations, in described step 4, often coil Folium Nelumbinis sabot in drip pan and be highly no more than 5cm.

In the processing technology of aforementioned Zaizao oral formulations, in described step 4, baking temperature is 45 ~ 75 DEG C.

In the processing technology of aforementioned Zaizao oral formulations, in described step 4, drying time is 96 hours.

In the processing technology of aforementioned Zaizao oral formulations, described oral formulations is capsule, granule, pill or tablet.

The processing technology of described pill is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water 2 times, each 2 hours, collecting decoction, filters, and filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, when being concentrated into 80 DEG C, relative density is the extractum of 1.10; Then its excess-three 13 herbal medicine is ground into fine powder, sieves, mixing; With the general ball of above-mentioned extractum, make concentrated pill, 60-80 DEG C of drying, sugar coating, polishing, to obtain final product.

Zaizao oral formulations of the present invention is by Radix Angelicae Sinensis (processed with wine), Rhizoma Cyperi (processed with vinegar), the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Colla Corii Asini, Poria, Radix Codonopsis, the Radix Astragali, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi (steamed with wine), processed with vinegar Carapax Et Plastrum Testudinis, Fructus Corni, Radix Dipsaci, Cortex Eucommiae(processed with salt), Herba Cistanches, Fructus Rubi, Cornu Cervi Degelatinatum, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, Herba Leonuri, Rhizoma Corydalis, short Radix Notoginseng, processed with vinegar Folium Artemisiae Argyi, Fructus Foeniculi, Rhizoma Ligustici, Endoconcha Sepiae, Radix Sanguisorbae processed by wine, Fructus Alpiniae Oxyphyllae, Rhizoma Alismatis, processed with vinegar Folium Nelumbinis, Radix Gentianae Macrophyllae, Cortex Lycii, Radix Cynanchi Atrati, Cortex Ailanthi, succinum, Radix Scutellariae (processed with wine), Semen Ziziphi Spinosae, Radix Polygalae (processed), Pericarpium Citri Reticulatae and Radix Glycyrrhizae are made.Wherein, Radix Angelicae Sinensis, the root that (formal name used at school: Angelica sinensis) is Umbelliferae herbaceos perennial Radix Angelicae Sinensis.Nature and flavor: sweet, pungent, warm." WU Pu Bencao ": the legendary god of farming, Yellow Emperor, a legendary ruler, paulownia monarch, Bian Que: sweet, nontoxic.Qi primary, Thunder God: pungent, nontoxic.Li Shi: little temperature.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.Rhizoma Cyperi, Cyperus rotundus L., Chinese medicine name.For the dry rhizome of sedge dried tuber.Nature and flavor: pungent, micro-hardship, micro-sweet are flat.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.Radix Paeoniae Alba (formal name used at school: Peonia lactiflora Pall.) also claims Paeonia sterniana Fletcher in Journ., is Ranunculaceae Paeonia plant.The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.To the effect of cardiovascular system.Coronary artery dilator, reduce blood pressure (d-cachou extract and progallin A have antithrombotic and antiplatelet aggregative activity), liver protection effect.Obvious protective effect is had to hepatic injury caused by carbon tetrachloride, AFB1, D-galactosamine.Analgesic activity.Mouse writhing can be suppressed, shout, hot plate reaction, suppress writhing response to have synergism to morphine, and can resist that pentylenetetrazole is caused faints from fear.The Radix Paeoniae Alba treats dizziness that the high Sheng of liver-yang causes, dizzy yearningly, and the menoxenia that deficiency of YIN-blood causes, bleeding not during menses, also can treat malnutrition, exterior deficiency spontaneous perspiration.Radix Rehmanniae (Classification system: Rehmannia glutinosa (Gaetn.) Libosch.ex Fisch.etMey.), Scrophulariaceae Radix Rehmanniae belongs to herbaceos perennial, Gao Keda 30 centimetres, rhizome meat, yellow time fresh, under cultivation condition, stem aubergine.Diameter can reach 5.5 centimetres, and blade is avette to oblong, and vein caves in above, and flower is slightly arranged in raceme at stem top, the outer aubergine of corolla, Neihuang County purple, and coyote hole square is circular, and capsule is avette to long avette, the flowering fruit bearing stage 4-7 month.Function cures mainly: Radix Rehmanniae is cool in nature, sweet-bitter flavor, there are enriching yin and nourishing kidney, nourish blood enrich blood, effect of removing heat from blood.All deficiency of YIN blood deficiency person who suffer from deficiency of kidney Yang eat it, quite helpful.In addition, Radix Rehmanniae has heart tonifying diuresis, antipyretic antiinflammatory, promotes blood coagulation and falls hypoglycemic effect.Colla Corii Asini, YIN nourishing of enriching blood, moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, dysphoria and insomnia, xeropulmonary cough.Be rectangle block, square block or fourth shape.Pitchy is glossy.Matter is hard and crisp, and section light, fragment is looked in brown translucent illumination.Feeble QI, taste is micro-sweet.Poria, Chinese medicine name.For the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Excavate more than 7 ~ JIUYUE, dig out rear removing silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now scatter and disappear in wrinkle, the large portion of internal moisture for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed different parts cutting, dry in the shade, be called " Poria block " and " Indian buead tablet ".Sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Radix Codonopsis (formal name used at school; Codonopsis pilosula) sheet of ovalize or similar round, surperficial yellowish-brown or lark, tangent plane yellow-white or yellowish-brown, have crack or Flos Chrysanthemi stricture of vagina, there are the faint yellow center of circle in central authorities.Periphery yellowish white puts yellowish-brown, has vertical wrinkle.Have special aroma, taste is micro-sweet.Raw Radix Codonopsis sheet supplementing QI for promoting the production of body fluid power victory.Be usually used in gas Tianjin two to hinder or deficiency of both QI and blood.Radix Codonopsis sweet in the mouth, property is put down.Have invigorating the spleen and replenishing QI, quench the thirst, spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.Lazy speech is losed heart, myasthenia of limbs, be off one's feed, the deficiency of vital energy, gas Tianjin two are empty, QI and blood is two loses and the disease such as blood deficiency and yellow complexion.But exterior syndrome is not separated and can not the using of the fullness in the epigastrium and abdomen domination of pathogen.This product effect is similar to Radix Ginseng, and only the efficacy of a drug is weak.Control general deficiency syndrome, Radix Ginseng can be replaced to use; Collapse is heavily demonstrate,proved, then be still advisable with Radix Ginseng.Autumn excavates, and cleans, dries.Radix Codonopsis is put down, sweet in the mouth, there is effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, body immunity can also be strengthened, improve the activity of superoxide dismutase, strengthen the ability eliminating free radical, there is the effect of Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.Be applicable to deficiency of the spleen and lung, the cough of cardiopalmus of breathing hard, anorexia and loose stool, ulcer, anemia, dyspnea due to deficiency, interior-heat such as to quench one's thirst at the disease.The Radix Astragali, Astragalusmembranaceus (Fisch.) Bunge., has another name called continuous stilbene.Perennial herb, nature and flavor: sweet, tepor.Gui Jing: return lung, spleen, liver, kidney channel.Modern medicine study shows, the Radix Astragali has enhancing human body immunity function, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improves blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.Radix Astragali instant, can decoct soup, soft extracts, infusing drugs in wine, enter dish etc.Rhizoma Dioscoreae, Common Yam RhizomeWinged Yan Rhizome, also known as Rhizoma Dioscoreae, native potato, mountain Rhizoma Dioscoreae, RHIIZOMA DIOSCOREAE fr0m Henan of China, Rhizomadioscoreae, white Rhizoma Dioscoreae, be the medical herbs that " China's book on Chinese herbal medicine " records, medicinal source is Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome.Nature and flavor: sweet, flat, nontoxic.Gui Jing: return spleen, lung, kidney channel.Chinese medicine for lowering blood pressure LIUWEI DIHUANG WAN, Rehmanniae Bolus of Eight Ingredients, 'Guishao Dihuang ball etc., it is all the famous prescription having Rhizoma Dioscoreae to be made into, not only be used for the treatment of disease of suffering from a deficiency of the kidney, also be used for the treatment of the diseases such as hypertension, diabetes, asthma, neurasthenia and lumbago, slow down aging modern science proves, Rhizoma Dioscoreae can make the enzymatic activity of acceleration organism aging significantly reduce.Containing the Rehmanniae Bolus of Eight Ingredients of Rhizoma Dioscoreae, cure mainly sweating continuously due to deficiency after delivery.Soup falls clearly in guarantor unit, guarantor unit is cold falls soup, can control haematemesis and epistaxis; Cold pouring soup and stranguria marked by chyluria soup, can control and drench worm.Rhizoma Dioscoreae also can control pulmonary tuberculosis, typhoid fever and gynaecological disease etc., and this is all conducive to life lengthening.The Rhizoma Atractylodis Macrocephalae (zh ú), Classification system Atractylodesmacrocephala.Another name small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis etc., belong to Compositae, [WTBX herbaceos perennial.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.Mainly be distributed in the mountain area wetlands such as Sichuan, Yunnan, Guizhou.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, and for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, antiabortive." Fructus Ligustri Lucidi, Fructus Ligustri Lucidi, another name Fructus Ligustri Lucidi reality, Fructus Ilicis Purpureae, wax tree, Mus Chinese catalpa are the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi Ligustrum lucidum Ait..These product are avette, oval or kidney shape, long 6 ~ 8.5mm, diameter 3.5 ~ 5.5mm.Surface black purple or grey black, shrinkage is uneven, and base portion has carpopodium trace or tool Constellation calyx and short stalk.Body is light.Outer peel is thin, and mesocarp is softer, easily peels off, and endocarp is wooden, yellowish-brown, and tool indulges rib, breaks rear seed and is generally 1, kidney shape, atropurpureus, oiliness.Odorless, sweet in the mouth, micro-bitterness.Primary in Yangtze River in China basin and southern various places, Henan, Shaanxi, Gansu and other places, northern not too cold place is also introduced a fine variety, and also has distribution in Korea south, India.Fructus Ligustri Lucidi is the Chinese medicine of replenishing kidney-YIN, nourishing the liver to improve visual acuity simply, can treating the liver kidney deficiency, dizzy ear toot, the disease such as early whitening of hair and two blurred vision pastes.Meridian distribution of property and flavor: sweet, bitter, cold.Return liver, kidney channel, effect: liver and kidney tonifying, improving eyesight, clearind deficient heat.Cure mainly: have a dizzy spell, early whitening of beard and hair, blurring of vision, fever due to yin deficiency.Carapax Et Plastrum Testudinis is carapace and the sternite of Testudinidae animal Testudinis Chinemys reevesii (Gray), and meridian distribution of property and flavor: salty, sweet, is slightly cold.Return liver, kidney, heart channel.Function cures mainly: nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.Fructus Corni (formal name used at school: Cornus officinalis Sieb.et Zucc.), another name Fructus Corni, Fructus Corni, mountain in meat etc., machaka or dungarunga, high 4-10 rice; Bark taupe; Sprig is carefully cylindrical, without hair or rare raw and axil life by adhesion pubescence hibernaculum top, avette to lanceolar, by yellowish-brown pubescence.Brightly yellowish color, drupe oblong, long 1.2-1.7 centimetre, diameter 5-7 millimeter, red to aubergine; Bony nodule matter, narrow oblong, is about 12 millimeters, has several irregular rib stricture of vaginas.The florescence 3-4 month; The fruit phase 9-10 month.Mature fruit is Chinese medicine, and for vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Ancient times are often compared to male bonding.Radix Dipsaci, Dipsacales, Chinese medicine name.Having another name called shaven head, is the root of Dipsacaceae herbaceos perennial Radix Dipsaci, gains the name because of energy " synthetism of continuous folding ".Autumn excavates, and removing root head and fibrous root, be dried to half-dried with low baking temperature, when bank up " diaphoresis " is to inner virescence, then dries." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " meridians determine in tonifying liver, bone and muscle strengthening, and only in warp, (muscles and bones) is ached, and antiabortive, control married woman leucorrhea, tissue regeneration promoting blood, removing blood stasis with potent drugs blood, fall stillborn fetus, and cough-relieving is coughed hemoptysis, controls red white turbid urine." Cortex Eucommiae (formal name used at school Eucommiaulmoides Oliver), having another name called bakelite, is Eucommiaceae plant.Sweet in the mouth, warm in nature.There are liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, admittedly through antiabortive effect.Can treat the lumbago and skelalgia or aching and limp unable that insufficiency of kidney-YANG causes, born of the same parents' tire that deficiency of liver-QI causes is not solid, the diseases such as scrotum pruritus due to damp pathogen.Be listed in top grade in Shennong's Herbal.The modern study Cortex Eucommiae has rubbish in purged body, strengthens human body cell substance metabolism, prevents muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol, reduces body fat, recovers blood vessel elasticity, diuresis heat clearing away, broad-spectrum antiseptic, stimulating central nervous system, improves leukocyte pharmacological action.Herba Cistanches (formal name used at school: Cistanchedeserticola Ma), nature and flavor: sweet in the mouth; Salty; Warm in nature, Gui Jing: return kidney; Large intestine channel.Kidney-replenishing; Benefiting essence-blood; Intestine moistening road.Main kidney yang deficiency; The sexual impotence of asthenia of essence and blood; Seminal emission; Nebulousurine; The frequent micturition heeltap; Lumbago flaccidity of the lower limbs; Tinnitus order flower; Menstruation is spread out the phase; Infertility; Dryness of the intestine constipation.Fructus Rubi, Chinese medicine name.For the dry fruit of rosaceous plant rubus chingii Hu Rubus chingii Hu.Be distributed in the ground such as Jiangsu, Zhejiang, Anhui, Fujian, Jiangxi, Guangxi.There is supplementing the kidney to control the nocturnal reducing urination, effect of nourishing the liver to improve visual acuity.Be usually used in emission and spermatorrhea, enuresis frequent micturition, impotence and premature ejaculation, order is secretly dim-sighted.Nature and flavor: sweet in the mouth, acid, warm in nature.Gui Jing: return liver, kidney, urinary bladder channel.Cornu Cervi Degelatinatum, CervusnipponTemminck, for the angle of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus boil Colla cornus cervi after remaining bone slag.Meridian distribution of property and flavor: salty, temperature.Return liver, kidney channel.Function cures mainly: warming the kidney to activate YANG, astringing to arrest bleeding.Cure mainly spleen kidney yang flaccidity, lack of appetite and vomiting, leucorrhea, enuresis frequent micturition, metrostaxis, carbuncle sucutaneous nodule, leukorrhagia; Wound hemorrhage; Skin infection disunion of a specified duration.Rhizoma Chuanxiong (formal name used at school: Ligusticum chuanxiong hort), cultivated plant, main product in Sichuan (Guanxian county), in Yunnan, Guizhou, the ground such as Guangxi, be grown on gentle climatic environment.Be a kind of Chinese medicinal plant, be usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, the pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, and the up mountain peak that reaches is pushed up; Enter blood system again, descendingly reach the sea of blood.Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.Radix Salviae Miltiorrhizae, Chinese medicine name.For the dry root welding technology of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Spring, Qiu Erji excavate, removing silt, dry.Whole nation most area has distribution.Have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.Radix Achyranthis Bidentatae, another name: cattle knocks knee joint, Latin literary fame: Achyranthes bidentata Blume. Amaranthaceae, Achyranthes perennial herb, high 70-120 centimetre; Root is cylindrical, diameter 5-10 millimeter, khaki; Stem has corner angle or square, green or band purple, adularescent adhesion or carry out pubescence, or near without hair, and branch is to life.Oval or the elliptic-lanceolate of blade, minority falls lanceolar, base portion wedge shape or wide wedge shape, and there is adhesion on two sides or carries out pubescence; Staminodium top flat circle, slightly incises shape serration.Utricle square is circular, and yellowish-brown is smooth.Seed square is circular, yellowish-brown.The florescence 7-9 month, the fruit phase 9-10 month.Root is used as medicine, raw use, promoting blood circulation to restore menstrual flow.Herba Leonuri, has another name called: Tui, motherwort, Herba Leonuri, nine Rhizoma Paridis, Muscovitum grass, the gloomy base of a fruit, Classification system: Leonurus artemisia (Laur.) S.Y.Hu F is Labiatae, mother wort plant, summer-flowering.Its dry aerial parts are conventional Chinese medicine, and most of China area is all produced, and give birth to or endure cream and use.1 year or biennial herb the whole nation most area all have distribution, be born in hill wasteland, ridge, meadow etc.Pluck when the non-standard-sized sheet of riotous growth flower in summer, acrid in the mouth is bitter, cool, invigorates blood circulation, silts of dispelling, regulating menstruation, disappear water, treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu), has another name called: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis etc.Be Papaveraceae, Corydalis herbaceos perennial, tuber is spherical, petal aubergine; Capsule is cylindrical, and two ends are gradually narrow.Summer-flowering.Tuber is famous conventional Chinese medicine, containing more than 20 kinds of alkaloids, for promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, traumatic injury etc." detailed outline ": invigorate blood circulation, promoting the circulation of QI, pain relieving, diuresis.Rhizoma Corydalis, the stagnation of QI in energy promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body, among using, simply fantastic.Radix Notoginseng, Chinese medicine name.For the dry root welding technology of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen.Autumn excavates before the flowers are in blossom, cleans, and separately main root, a root and rhizome, dry.Supporting root is practised and is claimed " rib ", and rhizome is practised and claimed " clip ".Nature and flavor: sweet, micro-hardship, temperature.Gui Jing: return liver, stomach warp.Effect: dissipating blood stasis stops blooding, subduing swelling and relieving pain.Cure mainly: for spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.Folium Artemisiae Argyi, Chinese medicine name.For the dried leaves of feverfew Chinese mugwort Artemisia argyi Levl.et Vant..Pluck when summer, flower was not opened, removing impurity, dries.Nature and flavor: pungent, bitter, temperature.Gui Jing: return liver,spleen,kidney warp.Effect: warming the meridian for stopping bleeding, dispersing cold for relieving pain; External removing dampness to relieve itching.Cure mainly: for spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding is hemorrhage for deficient cold type.Fructus Foeniculi, Chinese medicine name.For the dry mature fruit of samphire Fructus Foeniculi Foeniculum vuLgare Mill..Autumn taps plant when fruit is first ripe, dries, lays fruit, removing impurity.Nature and flavor: acrid in the mouth, warm in nature.Gui Jing: return liver,kidney,spleen, stomach warp.Effect: Fructus Foeniculi has dispersing cold for relieving pain, effect of regulating qi-flowing for harmonizing stomach.Salt Fructus Foeniculi has effect of warming the kidney dispersing cold for relieving pain.Cure mainly: Fructus Foeniculi is used for colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, abdominal distention, lack of appetite and vomiting.Salt Fructus Foeniculi is used for colic of cold type stomachache, the testis swelling and hanging down of either of the testes, through cold stomachache.Rhizoma Ligustici, Chinese medicine name.For dry rhizome and the root of samphire Rhizoma Ligustici Ligusticum sinense Oliv. or Rhizoma Ligustici Ligusticum jeholense Nakai et Kitag..Autumn stem and leaf withered or the secondary spring emerges time excavate, removing silt, dries or dries.Nature and flavor: acrid in the mouth, warm in nature.Return urinary bladder channel.Effect: expelling wind and cold, removing damp and stopping pain.Cure mainly: for exterior syndrome due to wind-cold, top, mountain peak pain, rheumatic arthralgia.Endoconcha Sepiae, Chinese medicine name.For the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune Sepiellamaindroni deRoehebrune or golden cuttlefish Sepia esculenta Hoyle.Be distributed in the ground such as Zhejiang, Fujian, Shandong.There is astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, effect of removing dampness sore.Be usually used in hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, eczema eczema, ulcer being unable to heal.Radix Sanguisorbae (Classification system: Sanguisorba officinalis L.) is Rosaceae burnet herbaceos perennial, and function cures mainly: Radix Sanguisorbae root is used as medicine, cold nature, bitter in the mouth.Modern medicine study proves: Radix Sanguisorbae has hemostasis removing heat from blood, heat-clearing and toxic substances removing, astringing to arrest diarrhea and suppresses the effect of multiple pathogenic microorganism and tumor, haematemesis, dysentery can be treated, burn wound, eczema, upper gastrointestinal hemorrhage, Peptic Ulcers massive hemorrhage, have blood in stool, metrorrhagia, the disease such as Tuberculous pus infections and chronic osteomyelitis." detailed outline ": Radix Sanguisorbae, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels heat, controls defecation blood disorder.Hemostasis, get and cut off sheet and fry use, its tip then can promoting the circulation of blood, can not know.Yang Shiying cloud: all skin ulcer pain persons add Radix Sanguisorbae, and the person of itching adds Radix Scutellariae.Fructus Alpiniae Oxyphyllae (Classification system: Alpinia oxyphylla Miq.), another name: Fructus Alpiniae Oxyphyllae, Fructus Alpiniae Oxyphyllae.Zingiberaceae, Alpinia herbaceos perennial.Nature and flavor: pungent, temperature.Gui Jing: enter spleen, kidney channel.Function cures mainly: warming the spleen, warming the kidney, solid and gas, arresting seminal emission.Control cold air stomachache, invasion by pathogenic cold vomit and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine." detailed outline ": Fructus Alpiniae Oxyphyllae, row sun moves back the medicine of the moon also.Three Jiao, gate of vitality's gas weak person should it.Connect Yang Shiyuan " side of directing at " cloud: the heart sees the mother of spleen, feed, does not terminate in and spleen, and fire can give birth to scholar, when making psychological treatment enter in taste medicine, maybe mutually.Therefore ancients take food in medicine, multiple-purpose intelligence promoting, in soil, beneficial fire also.Control cold air stomachache, and deficiency of heart-QI, dream is let out, red turbid urine, and thermal burn is felt concerned about, haematemesis, metrorrhagia.Rhizoma Alismatis (formal name used at school: Alisma plantago-aquatica Linn.), perennial aquatic or swampweed basis.Herb is poisonous, and underground tuber toxicity is larger.Tuber diameter 1-3.5 centimetre, or larger.Flower pesticide is about 1 millimeter, oval, yellow, or light green; Achene is oval, or nearly square is circular, and seed puce, tool is protruding.Produce the provinces and regions such as Heilungkiang, Jilin.Be born in the shallow water band in lake, river bend, streams, pool, marsh, irrigation canals and ditches and low-level bog also have growth.Flower is comparatively large, and the florescence is longer, can be used for flower ornamental.Also can be used as medicine, cure mainly oedema due to nephritis, the disease such as pyelonephritis, enteritis are had loose bowels, dysuria.Folium Nelumbinis, Lotus Leaf, also known as Flos Nelumbinis stem, lotus stem.Nelumbonaceae Nelumbo perennial herb emergent aquactic plant, delicate fragrance rises loose; Have summer heat relieving and dampness eliminating, spleen invigorating yang invigorating, effect of dissipating blood stasis hemostasis, cures mainly summer-heat excessive thirst, has a headache dizzy, edema, lack of appetite abdominal distention, dysentery, leucorrhea, proctoptosis, spits blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, post partum longtime lochia, traumatic blood stasis.Radix Gentianae Macrophyllae (Gentianamacrophylla Pall.), another name: gentiana macrophylla, Gentiana macrophylla Pall., RADIX GENTIANAE MACROPHYLLAE.Herbaceos perennial, meridian distribution of property and flavor: pungent, bitter is flat.Return stomach, liver, gallbladder meridian.Function cures mainly: wind-damp dispelling, clearing away damp-heat, stopping numbness pain.For the contracture of muscle arteries and veins, joint is ached, afternoon fever, and infantile malnutrition generates heat.Cortex Lycii, another name: Chinese wolfberry skin is Solanaceae, Lycium, is the root bark of Fructus Lycii Lycium chinense Mill..Can be used as medicine, there is removing heat from blood except effects such as steaming, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis.Interior-heat is quenched one's thirst.Nature and flavor: cold in nature, sweet in the mouth.Radix Cynanchi Atrati, another name: common vetch grass, know that micro-old, old melon gourd dipper root, mountain cigarette root, hundred swing grass, Baima common vetch, Rhizoma Cynanchi Stauntonii, Radix Tylophorae arenicolae, Latin literary fame: Cynanchum atratum Bunge. asclepiadaceae, the upright perennial herb of Cynanchum, nature and flavor: bitter salty, cold.1. " herbal classic ": bitter in the mouth, flat.2. " not Lu ": salty, Great Cold, nontoxic.Gui Jing: enter lung, stomach, kidney channel.Function cures mainly: clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment.For pathogenic warmth wound battalion heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood, swollen ulcer drug.Knife injury.Cortex Ailanthi, Chinese medicine name.For dry root bark or the dried bark of quassia ailanthus altissima (mill.) swingle Ailanthusaltissima (Mill.) Swingle.Bitter in the mouth, puckery, cold in nature.Return large intestine, liver, stomach warp.Heat clearing and damp drying, astringent therapy leukorrhagia stopping, antidiarrheal, hemostasis.Cure mainly for leucorrhea with red and white discharge, damp-heat dysentery, chronic diarrhea chronic dysentery, has blood in stool, metrorrhagia.Succinum, Amber, be time immemorial the resin of Pinaceae pine genus plant bury in stratum, through the differentiation in very long years and the fossil formed.In Middle Ages, succinum is opened and be used for the treatment of ulcer, migraine, insomnia, alimentary toxicosis, jaundice, infertility, malaria, asthma, consumptive disease, tumor and other diseases in prescription by the doctor in Europe.In the Russia in tsar's period, it is believed that wearing necklace that succinum makes can allow ailing away from oneself and children, and anemia of pregnant woman wear succinum necklace can be antiabortive, contribute to smooth production.In Germany, child has on the tooth of succinum necklace in order to them can be allowed not grow firm health sorely on neck.And in the medicine book in 19th century, we almost can find the record for the treatment of various disease about succinum.Radix Scutellariae (processed with wine): get scutellaria tablet, plant section, processs method fried dry according to wine.A kind of Chinese medicine.Main Function: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Meridian distribution of property and flavor: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Primary efficacy: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Semen Ziziphi Spinosae, Ziziphus jujuba Mill.var.spinosa, another name Semen Ziziphi Spinosae, jujube nucleus, Fructus Choerospondiatis core.Remove sarcocarp, nucleocapsid by Rhamnaceae arbor Ziziphi Spinosae mature fruit, collect seed, dry and form.Be born in endroit, roadside, mainly originate in the ground such as Henan, Hebei, Shaanxi, Liaoning, Shanxi, Shandong, Yunnan.Gather during fruit maturation in autumn, remove sarcocarp and stone, get seed, life is used or micro-stir-fry is used.Record in China's medicine book Shennong's Herbal the earliest: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae also." record in Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, " insomnia due to insufficiency of the gallbladder-qi in ripe treatment, the disease of excessive thirst sweating due to debility for Semen Ziziphi Spinosae; Life is treated gallbladder-heat and is slept well, and all foot faints cloudy few positive medicine also.Nourishing the liver, mind calming, calms the nerves, arresting sweating.Radix Polygalae (formal name used at school: Polygala tenuifolia Willd), You Ming Lush Rao, Ji Tseng-Lan etc.Produce northeast, North China, northwest and Central China and Sichuan; Perennial herb, main root is sturdy, phloem meat.The function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Pericarpium Citri Reticulatae, Chinese medicine name.For the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or cold drying.Bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Cure mainly: for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.Radix Glycyrrhizae, (formal name used at school: Glycyrrhiza uralensis Fisch) is called: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.Pulse family, Glycyrrhiza perennial herb, root and root stock sturdy, be a kind of tonification Chinese herbal medicine.To the good a kind of medicine of human body, medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, long 25 ~ 100 centimetres, diameter 0.6 ~ 3.5 centimetre.Crust degree of tightness differs, the brown or taupe brown of surface red.Rhizome is cylindrical, and there is bud trace on surface, has marrow in the middle part of section.Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.Happiness is dark moist, the low dry climate of long temperature at sunshine.The many growths of Radix Glycyrrhizae are in arid, semiarid desert steppe, desert edge and loess hill area.Root and Rootstock hyoscine.

In the method for existing production FUKE ZAIZAO WAN, the vinegar method that Folium Nelumbinis adopts is: get clean Folium Nelumbinis, fries to surface coke black, spray vinegar, fried dry according to stir-fry carbon method.Every 100kg Folium Artemisiae Argyi, uses vinegar 10kg.But the Folium Nelumbinis adopting existing processing procedure to make, in the Zaizao preparation made, the effective ingredient of Folium Nelumbinis is not easily measured.Inventor finds in technical study, Folium Nelumbinis is carried out washing, dries; Spray vinegar, after stirring, moistening is after 20 minutes, and with slow fire heating, fry to when becoming yellowish green color from celadon, taking-up cools; Highly be no more than 5cm in sabot, at 45 ~ 75 DEG C, dry 96 hours, every 12 hours of period turned over medicine once.Every 100kg Folium Nelumbinis, uses vinegar 20kg.In the Zaizao oral formulations made by this concocting method, the content of Folium Nelumbinis effective ingredient adds much unexpectedly, and therefore this technique facilitates the dissolution rate of effective ingredient in Folium Nelumbinis.

Compared with prior art, in Zaizao oral formulations prepared by the method for the invention, the effective ingredient of Folium Nelumbinis is easily measured, and the effective ingredient of the Folium Nelumbinis measured is high.Effectively can improve the drug effect of Zaizao oral formulations.Reach goal of the invention.

Invention has been a large amount of experimentatioies, is below the result of experimentation of the present invention:

Experimental example: in Folium Nelumbinis, general flavone content is investigated

One, raw material

1, pill of the present invention, is prepared by the method for embodiment 1.

2, existing FUKE ZAIZAO WAN, is prepared by standard technology, as follows:

Prescription: Radix Angelicae Sinensis (processed with wine) 65.14g, Rhizoma Cyperi (processed with vinegar) 65.14g, Radix Paeoniae Alba 43.43g, Radix Rehmanniae Preparata 21.71g, Colla Corii Asini 10.86g, Poria 65.14g, Radix Codonopsis 21.71g, Radix Astragali 21.71g, Rhizoma Dioscoreae 32.57g, Rhizoma Atractylodis Macrocephalae 16.28g, wine Fructus Ligustri Lucidi 43.43g, Carapax Et Plastrum Testudinis (processed with vinegar) 32.57g, Fructus Corni 21.71g, Radix Dipsaci 21.71g, Cortex Eucommiae(processed with salt) 21.71g, Herba Cistanches 10.86g, Fructus Rubi 16.28g, Cornu Cervi Degelatinatum 5.43g, Rhizoma Chuanxiong 43.43g, Radix Salviae Miltiorrhizae 21.71g, Radix Achyranthis Bidentatae 16.28g, Herba Leonuri 21.71g, Rhizoma Corydalis 16.28g, Radix Notoginseng (short) 5.43g, Folium Artemisiae Argyi (processed with vinegar) 43.43g, Fructus Foeniculi 21.71g, Rhizoma Ligustici 21.71g, Endoconcha Sepiae 32.57g, Radix Sanguisorbae (wine is processed) 32.57g, Fructus Alpiniae Oxyphyllae 10.86g, Rhizoma Alismatis 21.71g, Folium Nelumbinis (processed with vinegar) 16.28g, Radix Gentianae Macrophyllae 21.71g, Cortex Lycii 21.71g, Radix Cynanchi Atrati 43.43g, Cortex Ailanthi 32.57g, succinum 5.43g, Radix Scutellariae (processed with wine) 32.57g, Semen Ziziphi Spinosae 10.86g, Radix Polygalae (processed) 16.28g, Pericarpium Citri Reticulatae 32.57g and Radix Glycyrrhizae 21.71g.

Technique: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water 2 times, each 2 hours, collecting decoction, filtered, and filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, when being concentrated into 80 DEG C, relative density is the extractum of 1.10; Then all the other medicines are ground into fine powder, sieve, mixing; With the general ball of above-mentioned extractum, make concentrated pill, 60-80 DEG C of drying, sugar coating, polishing, to obtain final product.

The method of wherein said processed with vinegar Folium Nelumbinis is: get clean Folium Nelumbinis, fries to surface coke black, spray vinegar, fried dry according to stir-fry carbon method.Every 100kg Folium Artemisiae Argyi, uses vinegar 10kg.

3. rutin standard substance (chromatographically pure), AB-macroporous adsorbent resin (Chemical Plant of Nankai Univ.), ethanol (AR),

Other reagent are analytical pure.

4. instrument Portable high speed Chinese medicine grinder (great virtue Chinese traditional medicine machine company limited of Wenling city), Rotary Evaporators (Ying Yu Yu Hua instrument plant of Gongyi City), HH-S type thermostat water bath (Ying Yu Yu Hua instrument plant of Gongyi City), HL-2 type constant flow pump (Qingpu Shanghai Hu Xi instrument plant), the automatic fraction collector of BSZ-(Qingpu Shanghai Hu Xi instrument plant) SP-1910UVPC dual-beam ultraviolet-uisible spectrophotometer (Shanghai Spectrum Apparatus Co., Ltd.), Soxhlet extraction device etc.

Two, experimental technique

1. the extraction of flavone

Get pill of the present invention, pulverize, add normal hexane, 80 DEG C of soxhlet type 6h are colourless to backflow, put in people's fume hood air-dry, stand-by.Take the powder of a certain amount of porphyrize, with certain density ethanol (95%, V/V) } mix, stir, water bath with thermostatic control lixiviate final vacuum sucking filtration, filtering residue extracts by the ethanol second time of same concentrations again, filters, merging filtrate.Extracting solution is after concentrated, and upper AB-8 resin column, uses ethanol (V/V) eluting of distilled water and 70% respectively, and alcohol wash part is settled to certain volume through concentrated, and 4 DEG C of cold preservations are stand-by, must collect liquid 1.

Enchashment has FUKE ZAIZAO WAN, and pulverize, add normal hexane, 80 DEG C of soxhlet type 6h are colourless to backflow, put in people's fume hood air-dry, stand-by.Take the powder of a certain amount of porphyrize, with certain density ethanol (95%, V/V) } mix, stir, water bath with thermostatic control lixiviate final vacuum sucking filtration, filtering residue extracts by the ethanol second time of same concentrations again, filters, merging filtrate.Extracting solution is after concentrated, and upper AB-8 resin column, uses ethanol (V/V) eluting of distilled water and 70% respectively, and alcohol wash part is settled to certain volume through concentrated, and 4 DEG C of cold preservations are stand-by, must collect liquid 2.

2. the mensuration of flavones content

The determination of 2.1 maximum absorption wavelengths get respectively 100 microlitres collection liquid 1, collect liquid 2 and rutin titer, add the ethanol of 2.9mL70%, under 190-400nm, its absorption curve is scanned with SP-1910UVPC dual-beam ultraviolet-uisible spectrophotometer, relatively two scanning curves, determine that the maximum absorption wavelength of Folium Nelumbinis is 360nm.

The preparation of 2.2 rutin standard curve accurately takes rutin standard substance 5mg, and 70% EtOH Sonicate ripple dissolves, standardize solution in 50mL volumetric flask.The rutin solution 0.0,1.0,2.0,3.0,4.0,5.0mL getting 0.1mg/mL respectively in 6 10mL volumetric flasks, with 70% ethanol standardize solution.Get the rutin solution of 4 milliliters of variable concentrations, the solvent of extraction is blank, surveys its absorbance respectively at wavelength 360nm place, draws rutin standard curve.

The mensuration of 2.3 flavones contents is got a certain amount of collection liquid 1 respectively and collects liquid 2, after above-mentioned same process, measure absorbance with under 360nm, go out to collect the concentration of lotus flavone in liquid according to regression equation calculation and calculate the content of flavone in pill of the present invention and existing pill.

3 repeatability experiments

By the method preparing rutin standard curve, get the standard solution 4 parts that 4mL concentration is 30 micrograms per millilitre, at 360nm wavelength place, measure absorbance.

4 average recovery tests

Accurately get collection liquid 1 and collection each 4 parts of liquid 2 that 0.5mL concentration is 2.866mg/mL respectively, add a certain amount of rutin standard substance successively, undertaken by aforesaid operations method, adopt UV method to measure absorbance, calculate the content of total flavones, and calculate average recovery.

5 results and analysis

5.1 general flavone contents with the concentration of rutin titer (C) for abscissa, absorbance (A) is the standard curve of vertical coordinate, drafting, carries out linear regression with method of least square, regression equation is: A=32.357 × C 1, coefficient R=0.9998.

The absorbance measurements collecting liquid 1 and collection liquid 2 being substituted into rutin regression equation, being about 2.79% through calculating the content collecting total flavones in liquid 1.The content collecting total flavones in liquid 2 is about 1.68%, because flavone gruff bring up substance impurities (fat-soluble pigment etc.) is more, can affect the accuracy of measurement result, carry out assay again after therefore must being isolated purification by AB-8 resin column.

5.2 repeatability experimental results are in table 1.

Table 1 rutin standard substance repeatability experimental result

As can be seen from the table, measure rutin content by UV method, standard deviation and relative standard deviation are all less, and experimental result favorable reproducibility, the data obtained is accurate.

5.3 average recoveries are tested in table 2 and table 3.

Table 2 average recovery result of the test

Table 3 average recovery result of the test

Result shows, adopts UV method to measure collection liquid 1 higher with the average recovery of the Flavonoid Content collected in liquid 1, is respectively 99.4% and 98.9%; Relative standard deviation is 1.72% and 1.92%, less; Accuracy is higher.

5.4 sample determinations respectively accurate absorption are collected liquid 1 and collect each 0.4mL of liquid 2, add 80% ethanol 0.1mL, by the operation of said determination method, according to regression equation calculation general flavone content.It the results are shown in Table 4.

Table 4 flavones content determine result

Conclusion: compared with existing FUKE ZAIZAO WAN, in pill of the present invention, the content of Folium Nelumbinis effective ingredient flavone is higher.In like manner, the oral formulations of other dosage forms made according to extracting method of the present invention, the active constituent content of Folium Nelumbinis also should increase.

Detailed description of the invention:

Embodiment 1:

Formula: Radix Angelicae Sinensis (processed with wine) 65.14g, Rhizoma Cyperi (processed with vinegar) 65.14g, Radix Paeoniae Alba 43.43g, Radix Rehmanniae Preparata 21.71g, Colla Corii Asini 10.86g, Poria 65.14g, Radix Codonopsis 21.71g, Radix Astragali 21.71g, Rhizoma Dioscoreae 32.57g, Rhizoma Atractylodis Macrocephalae 16.28g, wine Fructus Ligustri Lucidi 43.43g, processed with vinegar Carapax Et Plastrum Testudinis 32.57g, Fructus Corni 21.71g, Radix Dipsaci 21.71g, Cortex Eucommiae(processed with salt) 21.71g, Herba Cistanches 10.86g, Fructus Rubi 16.28g, Cornu Cervi Degelatinatum 5.43g, Rhizoma Chuanxiong 43.43g, Radix Salviae Miltiorrhizae 21.71g, Radix Achyranthis Bidentatae 16.28g, Herba Leonuri 21.71g, Rhizoma Corydalis 16.28g, short Radix Notoginseng 5.43g, processed with vinegar Folium Artemisiae Argyi 43.43g, Fructus Foeniculi 21.71g, Rhizoma Ligustici 21.71g, Endoconcha Sepiae 32.57g, Radix Sanguisorbae 32.57g processed by wine, Fructus Alpiniae Oxyphyllae 10.86g, Rhizoma Alismatis 21.71g, processed with vinegar Folium Nelumbinis 16.28g, Radix Gentianae Macrophyllae 21.71g, Cortex Lycii 21.71g, Radix Cynanchi Atrati 43.43g, Cortex Ailanthi 32.57g, succinum 5.43g, Radix Scutellariae (processed with wine) 32.57g, Semen Ziziphi Spinosae 10.86g, Radix Polygalae (processed) 16.28g, Pericarpium Citri Reticulatae 32.57g and Radix Glycyrrhizae 21.71g.

The processing technology of described pill is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water 2 times, each 2 hours, collecting decoction, filters, and filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, when being concentrated into 80 DEG C, relative density is the extractum of 1.10; Then all the other medicines are ground into fine powder, sieve, mixing; With the general ball of above-mentioned extractum, make concentrated pill, 60-80 DEG C of drying, sugar coating, polishing, obtains pill.

The concocting method of wherein said processed with vinegar Folium Nelumbinis leaf is:

1, washing: get Folium Nelumbinis and carry out washing, dry;

2, vinegar liquid moistening: get the Folium Nelumbinis after drying and put in demulcen container, sprays vinegar by the method for spray, and sprinkling limit, limit is stirred until evenly, then moistening is exhausted by Folium Nelumbinis medical material to vinegar liquid for 20 minutes completely; Every 100kg Folium Nelumbinis, uses 20kg vinegar;

3, fry medicine: to be put by Folium Nelumbinis complete for moistening in medicine roasting machine with slow fire heating, fry to become from celadon yellowish green color slightly dry time, taking-up cools;

4, dry: put in clean drip pan by the Folium Nelumbinis through parch, often coiling Folium Nelumbinis sabot and be highly no more than 5cm, is 60 DEG C in temperature, and dry 96 hours, every 12 hours of period turned over medicine once.

Specification: the heavy 2.6g of every 10 balls.

Usage and dosage: oral, 10 balls, 2 times on the one, a menstrual cycle is a course for the treatment of, starts to take or follow the doctor's advice through the last week.

Embodiment 2:

Formula: Radix Angelicae Sinensis (processed with wine) 70g, Rhizoma Cyperi (processed with vinegar) 70g, Radix Paeoniae Alba 50g, Radix Rehmanniae Preparata 30g, Colla Corii Asini 20g, Poria 70g, Radix Codonopsis 30g, Radix Astragali 30g, Rhizoma Dioscoreae 40g, Rhizoma Atractylodis Macrocephalae 20g, wine Fructus Ligustri Lucidi 50g, processed with vinegar Carapax Et Plastrum Testudinis 40g, Fructus Corni 30g, Radix Dipsaci 30g, Cortex Eucommiae(processed with salt) 30g, Herba Cistanches 20g, Fructus Rubi 20g, Cornu Cervi Degelatinatum 10g, Rhizoma Chuanxiong 50g, Radix Salviae Miltiorrhizae 30g, Radix Achyranthis Bidentatae 20g, Herba Leonuri 30g, Rhizoma Corydalis 20g, short Radix Notoginseng 10g, processed with vinegar Folium Artemisiae Argyi 50g, Fructus Foeniculi 30g, Rhizoma Ligustici 30g, Endoconcha Sepiae 40g, Radix Sanguisorbae 40g processed by wine, Fructus Alpiniae Oxyphyllae 20g, Rhizoma Alismatis 30g, processed with vinegar Folium Nelumbinis 20g, Radix Gentianae Macrophyllae 30g, Cortex Lycii 30g, Radix Cynanchi Atrati 50g, Cortex Ailanthi 40g, succinum 10g, Radix Scutellariae (processed with wine) 40g, Semen Ziziphi Spinosae 20g, Radix Polygalae (processed) 20g, Pericarpium Citri Reticulatae 40g and Radix Glycyrrhizae 30g.

The processing technology of described capsule is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water 2 times, each 2 hours, collecting decoction, filters, and filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, when being concentrated into 80 DEG C, relative density is the extractum of 1.10; Then all the other medicines are ground into fine powder, sieve, mixing; Mix with above-mentioned extractum, 60-80 DEG C of drying, filled capsules, obtains capsule.

The concocting method of described processed with vinegar Folium Nelumbinis is:

1, washing: get Folium Nelumbinis and carry out washing, dry;

2, vinegar liquid moistening: get the Folium Nelumbinis after drying and put in demulcen container, sprays vinegar by the method for spray, and sprinkling limit, limit is stirred until evenly, then moistening is exhausted by Folium Nelumbinis medical material to vinegar liquid for 25 minutes completely; Every 100kg Folium Nelumbinis, uses 20kg vinegar;

3, fry medicine: to be put by Folium Nelumbinis complete for moistening in medicine roasting machine with slow fire heating, fry to become from celadon yellowish green color slightly dry time, taking-up cools;

4, dry: put in clean drip pan by the Folium Nelumbinis through parch, often coiling Folium Nelumbinis sabot and be highly no more than 5cm, is 75 DEG C in temperature, and dry 105 hours, every 12 hours of period turned over medicine once.

Specification: every 10 heavy 2.6g.

Usage and dosage: oral, one time 10,2 times on the one, a menstrual cycle is a course for the treatment of, starts to take or follow the doctor's advice through the last week.

Embodiment 3.

Formula: Radix Angelicae Sinensis (processed with wine) 60g, Rhizoma Cyperi (processed with vinegar) 60g, Radix Paeoniae Alba 40g, Radix Rehmanniae Preparata 15g, Colla Corii Asini 5g, Poria 60g, Radix Codonopsis 15g, Radix Astragali 15g, Rhizoma Dioscoreae 25g, Rhizoma Atractylodis Macrocephalae 10g, wine Fructus Ligustri Lucidi 40g, processed with vinegar Carapax Et Plastrum Testudinis 25g, Fructus Corni 15g, Radix Dipsaci 15g, Cortex Eucommiae(processed with salt) 15g, Herba Cistanches 5g, Fructus Rubi 10g, Cornu Cervi Degelatinatum 2g, Rhizoma Chuanxiong 40g, Radix Salviae Miltiorrhizae 15g, Radix Achyranthis Bidentatae 10g, Herba Leonuri 15g, Rhizoma Corydalis 10g, short Radix Notoginseng 2g, processed with vinegar Folium Artemisiae Argyi 40g, Fructus Foeniculi 15g, Rhizoma Ligustici 15g, Endoconcha Sepiae 25g, Radix Sanguisorbae 25g processed by wine, Fructus Alpiniae Oxyphyllae 5g, Rhizoma Alismatis 15g, processed with vinegar Folium Nelumbinis 10g, Radix Gentianae Macrophyllae 15g, Cortex Lycii 15g, Radix Cynanchi Atrati 40g, Cortex Ailanthi 25g, succinum 2g, Radix Scutellariae (processed with wine) 25g, Semen Ziziphi Spinosae 5g, Radix Polygalae (processed) 10g, Pericarpium Citri Reticulatae 25g and Radix Glycyrrhizae 15g

The processing technology of described pill is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water 2 times, each 2 hours, collecting decoction, filters, and filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, when being concentrated into 85 DEG C, relative density is the extractum of 1.10; Then all the other medicines are ground into fine powder, sieve, mixing; Mix with above-mentioned extractum, tabletting, obtain tablet.With the general ball of above-mentioned extractum, make concentrated pill, 60-80 DEG C of drying, sugar coating, polishing, obtains pill.

The concocting method of described processed with vinegar Folium Artemisiae Argyi is:

1, washing: get Folium Nelumbinis and carry out washing, dry;

2, vinegar liquid moistening: get the Folium Nelumbinis after drying and put in demulcen container, sprays vinegar by the method for spray, and sprinkling limit, limit is stirred until evenly, then moistening is exhausted by Folium Nelumbinis medical material to vinegar liquid for 15 minutes completely; Every 100kg Folium Nelumbinis, uses 20kg vinegar;

3, fry medicine: to be put by Folium Nelumbinis complete for moistening in medicine roasting machine with slow fire heating, fry to become from celadon yellowish green color slightly dry time, taking-up cools;

4, dry: put in clean drip pan by the Folium Nelumbinis through parch, often coiling Folium Nelumbinis sabot and be highly no more than 5cm, is 45 DEG C in temperature, and dry 85 hours, every 12 hours of period turned over medicine once.

Specification: every 10 heavy 2.6g.

Usage and dosage: oral, one time 10,2 times on the one, a menstrual cycle is a course for the treatment of, starts to take or follow the doctor's advice through the last week.

Claims (10)

1. a processing technology for Zaizao oral formulations, is characterized in that: described Zaizao oral formulations calculates by weight, is made up of following composition: Radix Angelicae Sinensis (processed with wine) 60-70 part, Rhizoma Cyperi (processed with vinegar) 60-70 part, Radix Paeoniae Alba 40-50 part, Radix Rehmanniae Preparata 15-30 part, Colla Corii Asini 5-20 part, Poria 60-70 part, Radix Codonopsis 15-30 part, Radix Astragali 15-30 part, Rhizoma Dioscoreae 25-40 part, Rhizoma Atractylodis Macrocephalae 10-20 part, Fructus Ligustri Lucidi (steamed with wine) 40-50 part, processed with vinegar Carapax Et Plastrum Testudinis 25-40 part, Fructus Corni 15-30 part, Radix Dipsaci 15-30 part, Cortex Eucommiae 15-30 part, Herba Cistanches 5-20 part, Fructus Rubi 10-20 part, Cornu Cervi Degelatinatum 2-10 part, Rhizoma Chuanxiong 40-50 part, Radix Salviae Miltiorrhizae 15-30 part, Radix Achyranthis Bidentatae 10-20 part, Herba Leonuri 15-30 part, Rhizoma Corydalis 10-20 part, short Radix Notoginseng 2-10 part, processed with vinegar Folium Artemisiae Argyi 40-50 part, Fructus Foeniculi 15-30 part, Rhizoma Ligustici 15-30 part, Endoconcha Sepiae 25-40 part, Radix Sanguisorbae 25-40 part processed by wine, Fructus Alpiniae Oxyphyllae 5-20 part, Rhizoma Alismatis 15-30 part, processed with vinegar Folium Nelumbinis 10-20 part, Radix Gentianae Macrophyllae 15-30 part, Cortex Lycii 15-30 part, Radix Cynanchi Atrati 40-50 part, Cortex Ailanthi 25-40 part, succinum 2-10 part, Radix Scutellariae (processed with wine) 25-40 part, Semen Ziziphi Spinosae 5-20 part, Radix Polygalae (processed) 10-20 part, Pericarpium Citri Reticulatae 25-40 part and Radix Glycyrrhizae 15-30 part, the processing technology of described oral formulations is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water, and decocting liquid filters, and filtrate concentrates, separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, be condensed into extractum, then all the other medicines are ground into fine powder, sieve, mixing, mix with above-mentioned extractum, conveniently technique makes oral formulations.

2. the processing technology of Zaizao oral formulations according to claim 1, is characterized in that: the concocting method of described processed with vinegar Folium Nelumbinis is:

(1) washing: get Folium Nelumbinis and carry out washing, dry;

(2) vinegar liquid moistening: get the Folium Nelumbinis after drying and put in demulcen container, sprays vinegar by the method for spray, and sprinkling limit, limit is stirred until evenly, then moistening is exhausted by Folium Nelumbinis to vinegar liquid for 15 ~ 25 minutes completely;

(3) fry medicine: put by Folium Nelumbinis complete for moistening in medicine roasting machine and heat with slow fire, when frying slightly dry to moisture evaporation, when surface intensification, the sense of tool light, taking-up cools;

(4) dry: put in clean drip pan by the Folium Nelumbinis through parch, put into drying room drying 85 ~ 105 hours, every 12 hours of period turned over medicine once.

3. the processing technology of Zaizao oral formulations according to claim 2, is characterized in that, in described step (2), the weight ratio of Folium Nelumbinis and vinegar is 100:20.

4. the processing technology of Zaizao oral formulations according to claim 2, is characterized in that, in described step (2), the moistening time is 20 minutes.

5. the processing technology of Zaizao oral formulations according to claim 3, is characterized in that, in described step (4), often coils Folium Nelumbinis sabot and be highly no more than 5cm in drip pan.

6. the processing technology of Zaizao oral formulations according to claim 2, is characterized in that, in described step (4), baking temperature is 45 ~ 75 DEG C.

7. the processing technology of Zaizao oral formulations according to claim 2, is characterized in that, in described step (4), drying time is 96 hours.

8. the processing technology of Zaizao oral formulations according to claim 1, it is characterized in that: the processing technology of described oral formulations is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water 2 times, each 2 hours, collecting decoction, filter, filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, when being concentrated into 80 DEG C, relative density is the extractum of 1.10; Then all the other medicines are ground into fine powder, sieve, mixing; Mix with above-mentioned extractum, conveniently technique makes oral formulations.

9. the processing technology of Zaizao oral formulations according to claim 1 or 8, is characterized in that: described oral formulations is capsule, granule, pill or tablet.

10. the processing technology of Zaizao oral formulations according to claim 9, it is characterized in that: the processing technology of described pill is: the Radix Astragali, Cortex Eucommiae(processed with salt), Radix Rehmanniae Preparata, Radix Dipsaci, Radix Gentianae Macrophyllae, Herba Cistanches, Radix Achyranthis Bidentatae, Cortex Lycii are decocted with water 2 times, each 2 hours, collecting decoction, filter, filtrate concentrates; Separately get add water molten and above-mentioned concentrated solution of Colla Corii Asini to merge, when being concentrated into 80 DEG C, relative density is the extractum of 1.10; Then all the other medicines are ground into fine powder, sieve, mixing, mix with above-mentioned extractum, general ball, makes concentrated pill, 60-80 DEG C of drying, and sugar coating, polishing, to obtain final product.