CN104069224A - Plaster for promoting qi and relaxing bowels and preparation method of plaster - Google Patents
Plaster for promoting qi and relaxing bowels and preparation method of plaster Download PDFInfo
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- CN104069224A CN104069224A CN201410306330.3A CN201410306330A CN104069224A CN 104069224 A CN104069224 A CN 104069224A CN 201410306330 A CN201410306330 A CN 201410306330A CN 104069224 A CN104069224 A CN 104069224A
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Abstract
The invention discloses a plaster for promoting qi and relaxing bowels and a preparation method of the plaster. The effective components of the plaster include a traditional Chinese medicine micro-powder, a heating material and an appropriate substrate. The traditional Chinese medicine micro-powder is mainly prepared from 10%-15% of pine spike powder, 25%-40% of rhubarb, 10%-15% of fructus aurantii immaturus, 10%-15% of polygonum multiflorum, 5%-10% of peach kernel, 5%-10% of hemp, 8%-12% of liquorice and 5-10% of mint; the heating material is composed of iron powder, activated carbon and sodium chloride in the ratio of 5: 1: 1. The preparation method of the plaster comprises evenly mixing the traditional Chinese medicine micro-powder, the heating material and a Cataplasm substrate in the ratio of 1: 1: 4 by stirring, coating, slitting and packaging in vacuum, thereby obtaining plasters. The plaster for promoting qi and relaxing bowels has lasting medicine release effect and high slow release effect; the plaster has excellent curative effect on promoting qi and relaxing bowels and treating diseases such as habitual constipation, postoperative intestinal tympanites and abdominal distention.
Description
Technical field
The invention belongs to a kind of Chinese herbs paste and preparation method thereof, particularly a kind of circulation of qi promoting relieving constipation subsides and preparation method for the treatment of the diseases such as constipation, wrist distention and fullness in the abdomen, postoperative intestinal tympanites.
Background technology
Emplastrum means medicine dissolution or is mixed in natural or synthesized polymer material substrate, spreads onto on whore backing material, and for the exterior-applied formulation sticking in skin, wherein the emplastrum taking water-soluble high-molecular material as substrate is called cataplasma.Cataplasma is a kind of external patch unguentum, has applicating history more of a specified duration in Japan.Be medicinal substances extract, medical material or/and after chemicals mixes with suitable hydrophilic matrix, be coated on the emplastrum of making on back lining materials, formed by backing (conventional non-woven fabrics, stretch fabric), mastic, anti-mucosa (isolating membrane on mastic surface).Its drug loading is large, and moisture retention is strong, good, ageing-resistant with the compatibility of skin; Can repeatedly take off subsides, stop administration at any time; Dosage is accurate, and blood drug level balance, without peak valley phenomenon, can reduce toxic and side effects; In commercial production, pollute without organic solvent, meet environmental requirement.
Traditional black plaster decocts with vegetable oil Chinese crude drug exactly under high-temperature condition, after certain degree, add again Plumbum preparatium, to " dripping into pearl " shape, and then cooling, beach is on cotton or kraft paper, when use, must heat with slow fire, this dosage form is in China's history of existing several thousand, from among the people to regular, this technique of pharmaceutical factory and dosage form are also being used, but perfect along with the development of medical sci-tech and various detection meanss, this dosage form is eliminated gradually, its deficiency have following some: 1) heavy metals exceeding standard, Plumbum preparatium itself is poisonous; 2) high temperature process is destroyed medicament effective component; 3) heat stream oil pollution is serious; 4) technique and technology are difficult to reach national GMP standard.
Rubber plaster patch selects chemical industry to synthesize colloid exactly, by after Chinese medicine powder or water medicine powder and colloid mixing, is coated on cotton or stretch fabric, more attached one deck Concha Arcae film or separate paper.Due to the restriction of the technique of this dosage form own, can only play the object of temporary transient pain relieving.Also be eliminated now.It can not conclude some completely: 1) owing to selecting chemical glue as substrate, although it is still very high to solve the ventilative irritated rate of problem differing from by punching.2) medicament contg is low, and coating only has 0.1mm, mostly only carrys out the temporary transient analgesic effect that plays by adding Western medicine pain relieving composition; 3) colloid molecular structure is tight, and in pharmaceutical pack is rolled in, medicament effective component cannot permeate at all, can only play the effect of sealing; 4) adopt gasoline etc. as solvent, processing is that danger has again pollution.
Room temperature pressure sensitive adhesive plaster, its technique is by after micro-powder of Chinese herbs, is added in room temperature pressure sensitive adhesive and stirs, equally coat on spun laced fabric or non-woven fabrics by the technique that is similar to industrial gummed tape, then select above separate paper is attached to, because production cost is low, can quantize again, outward appearance is good-looking again, adopted by a lot of producers, compare with rubber plaster, just on processing technology and standby material, make progress, just focus on its surface, but do not tackle the problem at its root.This dosage form is from following several deficiencies: 1) medicament contg is low, the super only 0.1mm of coating the same as rubber plaster; 2) play temporary transient analgesic effect by adding western medicine composition; 3) the bad control of viscosity, is not that not glue be exactly to take off to get off, unstable.
A kind of dosage form coming into vogue on market about calendar year 2001, this dosage form is to select the PUR of fusing point about 135 degree as carrying platform, concrete technology is first by after PUR naked light or electrical heating dissolving, add again Chinese medicine powder or western medicine composition, with industrial PUR flush coater or blade coating on non-woven fabrics or spun laced fabric, after rolling, be cut into lamellar with itemize microtome or die-cutting machine again, owing to using the spraying of industrial coating machine, plaster surfacing is smooth, coating can be thickeied again, add again the cooling rear high resilience of PUR, claim in the industry its " false bar cloth ", praised highly by domestic a lot of producer.But the angle that is placed on percutaneous dosing is said, also has the following disadvantages: 1) colloid molecular structure is tight, and Chinese medicine cannot permeate at all, just relies on western medicine composition to make temporary transient analgesic effect.2) sensation high resilience, but be absolutely not to there is moisture-keeping functions, just by coating layer thickness thickening, do not have moisturizing and control slow releasing function at all.
Gel rubber plaster adopts a kind of water-base resin rubber powder exactly, in water, dissolve, then add chemical drugs or micro-powder of Chinese herbs, as defervescence plaster used in the Japan of seeing on the market, the cold bar cream of Korea S adopts this dosage form exactly, this dosage form has approached real cataplasma, but basic internal structure and plastic property comprise that adherence force aspect is not good enough, owing to selecting water-base cement, human body just dissolves or comes off after sticking perspiration, and patches matrix layer all mummification again after moisture evaporation, without humidity-preserving type.
Wax plaster is that a kind of Cera Flava or industrial wax oil are substrate, in medicated powder is stirred in, is pressed into lamellar with oodle maker, become required specification with knife plate rolling cut, when use, must have slow fire heating, but proportioning control is bad, mostly there is stiff dry and cracked phenomenon, be referred to as in the industry " false black plaster ".Waste lamp oil by not sleeping at night and receive red technique lost along with tradition, this technique can only be selected by a lot of producers.But all do not reach the requirement of transdermal administration from patch state to Transdermal absorption effect.
Soak patch is exactly to use filling machine fill in 5 milliliters to 20 milliliters plastics or aluminium foil bag liquid medicine, then a thick spun laced fabric or the cotton of sucking blood are fixed on to plaster for cloth central authorities, liquid medicine painting is carried out moistening in the above, then sticking on human body uses, this dosage form also has the history of more than one thousand years in China, just processing technique difference, owing to using trouble and being not suitable for large-scale production, just use often at clinical orthopaedics, market circulation link is general.
It is that Chinese medicinal powder and iron powder, active carbon are mixed that this dosage form is pasted in hot moxibustion, add oxidant and then become packed with packer package encapsulation, when use, unpack, produce oxidation reaction with air, thereby reach the effect of thermotherapy and medication, rheumatic osteopathia is had to certain curative effect, but to other symptom DeGrains.
Be more than to the traditional plaster of China and novel dosage form, be introduced and analyze, differ from one another, but have certain shortcoming, be in particular in: the aspect Shortcomings such as anaphylaxis, content of dispersion, transdermal absorption factor, sticking strength, control slow release.
The object of the present invention is to provide a kind of patch product---circulation of qi promoting relieving constipation subsides and preparation method, taking water-soluble high-molecular material as main matrix, add medicine, make external preparation through techniques such as mixing, be coated with, cut, clinical practice is in diseases such as habitual constipation, wrist distention and fullness in the abdomen, postoperative intestinal tympaniteses.Polymer-based material in patch prepared by this method can absorb and carry the micro-powder of Chinese herbs that comprises multiple water solublity and liposoluble constituent better, and can be fast, the effective ingredient that comprises in transdermal release substrate enduringly.
Summary of the invention
Circulation of qi promoting relieving constipation is pasted, formed by micro-powder of Chinese herbs, heat object and suitable substrate, it is characterized in that micro-powder of Chinese herbs formula by: micro-powder of Chinese herbs formula is mainly made up of loose fringe powder 10%-15%, Radix Et Rhizoma Rhei 25%-40%, Fructus Aurantii Immaturus 10%-15%, Radix Polygoni Multiflori 10%-15%, Semen Persicae 5%-10%, Urtica cannabina L. 5%-10%, Radix Glycyrrhizae 8%-12%, Herba Menthae 5-10%; Heat object is made up of according to the ratio of 5: 1: 1 iron powder, active carbon, sodium chloride; Taking water-soluble high-molecular material as main matrix, add micro-powder of Chinese herbs, heat object, through stirring and evenly mixing, be coated with, cut, vacuum packaging forms.Above-mentioned circulation of qi promoting relieving constipation is pasted, and best micro-powder of Chinese herbs formula is made up of loose fringe powder 15, Radix Et Rhizoma Rhei 25, Fructus Aurantii Immaturus 15, Radix Polygoni Multiflori 10, Semen Persicae 10, Urtica cannabina L. 10, Radix Glycyrrhizae 8, Herba Menthae 5 (weight ratio); Micro-powder of Chinese herbs, heat object and catablasm base material mix according to the ratio of 1: 1: 4.
Above-mentioned qi-invigorating constipation-relieving is purchased from Tianjin Rui Kangbabu medicine bioengineering Science and Technology Ltd.
The preparation method that above-mentioned circulation of qi promoting relieving constipation is pasted is divided into:
1) micro-powder of Chinese herbs preparation
Above-mentioned medical material, through selecting, after weighing, is mixed according to aforementioned proportion, and being crushed to 120 orders, to pack seal of vessel into stand-by;
2) preparation of heat object
The abundant mix homogeneously of ratio iron powder, active carbon, sodium chloride according to 5: 1: 1, sealing saves backup;
3) preparation is pasted in circulation of qi promoting relieving constipation
Micro-powder of Chinese herbs, heat object are mixed according to the ratio of 1: 1: 4 with catablasm base material, stir that 15-20min mixes, is coated with, cuts, vacuum packaging obtains circulation of qi promoting relieving constipation of the present invention and paste with 1000-1200rpm rotating speed.
Pharmacology explanation
Pine fringe powder: contain nearly hundred kinds of enzymes, can promote gastrointestinal peristalsis, appetite stimulator, helps digest, and gastrointestinal dysfunction disease is had to obvious regulating action.
Radix Et Rhizoma Rhei: another name, general, Huang Liang, fire ginseng, skin are as, another name for Sichuan Province Radix Et Rhizoma Rhei.There is purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, effect of eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, injury from falling down.Nature and flavor: bitter, cold.Function cures mainly: the poison that purges heat, removing mass is stagnant, blood stasis expelling blood.The constipation of smelting excess-heat, food stagnation feeling of fullness etc.
Fructus Aurantii Immaturus: another name, goose eye Fructus Aurantii Immaturus.Meridian distribution of property and flavor: hardship; Pungent; Cold.Return spleen; Stomach; Liver; Heart channel.Effect: stop in stagnant; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.
Radix Polygoni Multiflori: another name, honey is fragrant, blue or green Radix Polygoni Multiflori, wide Radix Polygoni Multiflori etc.For the root of feverfew cloud Radix Polygoni Multiflori, Yuexi Radix Polygoni Multiflori, river Radix Polygoni Multiflori etc.Perennial herb, root is sturdy, the high 30-200cm of stem left and right.Nature and flavor: arduous, warm.Function cures mainly: promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.The smelting invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, vomiting etc.
Semen Persicae: have another name called white Semen Persicae, Bin Men, Fructus Canarii albi, semen arecae etc.For the seed of Zong Ge section plant Semen Persicae, Semen Persicae tree be for more than Qiao Gaodu can reach 10-18 rice, not branch, and leaf falls behind the obvious ring grain of formation.Mainly be distributed in the ground such as Yunnan, Guangdong, Taiwan, Guangxi.Nature and flavor: toil, temperature.Excessive Semen Persicae alkali causes sialorrhea, vomiting, diuresis, lethargy and convulsions.Function cures mainly: parasite killing, removing mass, the therapeutic method to keep the adverse QI flowing downwards, Hang Shui.Control malnutrition due to parasitic infestation, dyspepsia, institute's abdominal distention and pain etc.
Urtica cannabina L.: another name, Radix Angelicae Sinensis, cloud are returned, western Urtica cannabina L., Min Urtica cannabina L. etc.For the root of samphire Urtica cannabina L..Perennial herb, the high 40-100cm of stem left and right.Nature and flavor: Gan Xin, temperature.Function cures mainly: benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation.Control menoxenia, amenorrhea stomachache, dryness of the intestine dyschezia, tumor addiction knot poly-etc.
Radix Glycyrrhizae: sweet in the mouth, property is flat, nontoxic.Treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw pathogenic fire purging heat, the ripe use exterior cold of fall apart of use, goes pharyngalgia, removes pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.
Herba Menthae: cool in nature, sweet in the mouth is pungent, is a kind of conventional Chinese medicine, is of value to treatment accumulation of food in the stomach and intes tine due to indigestion, removes the gastral cavilty stagnant sensation that rises.Also can cure hiccup and spastic stomachache.In addition, Herba Menthae also has good wind dispelling effect in intestinal, can alleviate intestinal inflation, speed to delay myenteron wriggling, has the effect that slows down enterocele pain; Research shows, Herba Menthae can significantly promote Drug Percutaneous Absorption effect, and the effect of this promotion Transdermal absorption may be because menthol is by changing the transdermal penetration ability of structural change medicine of Stratum corneum lipids.
The mechanism of action of heat object: the stock and adjunct of heating is the general raw material in this area.Described heat object is by the effect of heating power, make in ointment bag the contained composition of each flavour of a drug particularly volatile ingredient constantly appear, through affected part, infiltrates rapidly focus deep tissue, promotes Drug Percutaneous Absorption.Produce thermotherapy and the common effect of medication, with reduction of patient malaise symptoms.Hot compress is a kind of important therapeutic treatment means, and hot compress can blood vessel dilating, improve affected part blood circulation, promote local metabolic, and rheumatism, pain, arthritis are had to good curative effect, takes hot compress can also strengthen drug absorption effect when Drug therapy.
Detailed description of the invention
Embodiment 1:
1) micro-powder of Chinese herbs preparation: the ratio of loose fringe powder 15, Radix Et Rhizoma Rhei 25, Fructus Aurantii Immaturus 15, Radix Polygoni Multiflori 10, Semen Persicae 10, Urtica cannabina L. 10, Radix Glycyrrhizae 8, Herba Menthae 5 (weight ratio) is mixed, and being crushed to 120 orders, to pack seal of vessel into stand-by;
The preparation of 2 heat object: the abundant mix homogeneously of ratio iron powder, active carbon, sodium chloride according to 5: 1: 1, sealing saves backup;
3) preparation is pasted in circulation of qi promoting relieving constipation: micro-powder of Chinese herbs, heat object are mixed according to the ratio of 1: 1: 4 with catablasm base material, with 1000-1200rpm rotating speed stirring 15-20min mix, be coated with, cut, vacuum packaging obtain circulation of qi promoting relieving constipation subsides of the present invention.
Circulation of qi promoting relieving constipation plaster formula is natural Chinese medicines, and compatibility is reasonable, prescription science, and treatment is parallel with conditioning, has no side effect; Technique advanced person, extracts active ingredients is thorough, ensures curative effect; Easy to use, safe and effective, non-stimulated, without irritated.The external use plaster being prepared into, improve preparation level, the blood drug level that causes because of oral medication is unbalanced, dosage is large, non-targeted organ absorbs side effect and interference and the stimulation of gastrointestinal are avoided, because the absorption of medicine is not by the first-pass effect of gastrointestinal and liver, reduce the loss of pharmaceutical compositions, what active ingredient was more stable enters blood flow, makes blood level be stabilized in valid density, and then retains and improved drug effect.
Claims (4)
1. a circulation of qi promoting relieving constipation is pasted, formed by micro-powder of Chinese herbs, heat object and suitable substrate, it is characterized in that micro-powder of Chinese herbs formula by: micro-powder of Chinese herbs formula is mainly made up of loose fringe powder 10%-15%, Radix Et Rhizoma Rhei 25%-40%, Fructus Aurantii Immaturus 10%-15%, Radix Polygoni Multiflori 10%-15%, Semen Persicae 5%-10%, Urtica cannabina L. 5%-10%, Radix Glycyrrhizae 8%-12%, Herba Menthae 5-10%; Heat object is made up of according to the ratio of 5: 1: 1 iron powder, active carbon, sodium chloride; Taking cataplasma as main matrix, add micro-powder of Chinese herbs, heat object, through stirring and evenly mixing, be coated with, cut, vacuum packaging forms.
2. circulation of qi promoting relieving constipation according to claim 1 is pasted, and it is characterized in that: best micro-powder of Chinese herbs formula is made up of loose fringe powder 15, Radix Et Rhizoma Rhei 25, Fructus Aurantii Immaturus 15, Radix Polygoni Multiflori 10, Semen Persicae 10, Urtica cannabina L. 10, Radix Glycyrrhizae 8, Herba Menthae 5 (weight ratio).
3. circulation of qi promoting relieving constipation according to claim 1 is pasted, and it is characterized in that: micro-powder of Chinese herbs, heat object and catablasm base material mix according to the ratio of 1: 1: 4.
4. a preparation method is pasted in circulation of qi promoting relieving constipation, it is characterized in that preparation method to be divided into:
1) micro-powder of Chinese herbs preparation
Above-mentioned medical material, through selecting, after weighing, is mixed according to aforementioned proportion, and being crushed to 120 orders, to pack seal of vessel into stand-by;
2) preparation of heat object
The abundant mix homogeneously of ratio iron powder, active carbon, sodium chloride according to 5: 1: 1, sealing saves backup;
3) preparation is pasted in circulation of qi promoting relieving constipation
Micro-powder of Chinese herbs, heat object are mixed according to the ratio of 1: 1: 4 with catablasm base material, stir that 15-20min mixes, is coated with, cuts, vacuum packaging obtains circulation of qi promoting relieving constipation of the present invention and paste with 1000-1200rpm rotating speed.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410306330.3A CN104069224A (en) | 2014-06-24 | 2014-06-24 | Plaster for promoting qi and relaxing bowels and preparation method of plaster |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410306330.3A CN104069224A (en) | 2014-06-24 | 2014-06-24 | Plaster for promoting qi and relaxing bowels and preparation method of plaster |
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| CN104069224A true CN104069224A (en) | 2014-10-01 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055629A (en) * | 2014-06-24 | 2014-09-24 | 凌中鑫 | Qi-circulation-promoting and bowel-relaxing postoperative physiotherapy belt and preparing method of Qi-circulation-promoting and bowel-relaxing postoperative physiotherapy belt |
| CN107997871A (en) * | 2017-11-27 | 2018-05-08 | 江西珍视明药业有限公司 | A kind of eye-care fever tablet and preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876086A (en) * | 2006-02-16 | 2006-12-13 | 张高红 | Qi-invigorating constipation-relieving and preparation method thereof |
| CN102670961A (en) * | 2012-05-15 | 2012-09-19 | 宋协勘 | Chinese medicament for treating middle and old aged habitual constipation |
| CN103463520A (en) * | 2013-08-10 | 2013-12-25 | 安玉霞 | Qi moving and bowel relaxing plaster and preparation method thereof |
-
2014
- 2014-06-24 CN CN201410306330.3A patent/CN104069224A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876086A (en) * | 2006-02-16 | 2006-12-13 | 张高红 | Qi-invigorating constipation-relieving and preparation method thereof |
| CN102670961A (en) * | 2012-05-15 | 2012-09-19 | 宋协勘 | Chinese medicament for treating middle and old aged habitual constipation |
| CN103463520A (en) * | 2013-08-10 | 2013-12-25 | 安玉霞 | Qi moving and bowel relaxing plaster and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055629A (en) * | 2014-06-24 | 2014-09-24 | 凌中鑫 | Qi-circulation-promoting and bowel-relaxing postoperative physiotherapy belt and preparing method of Qi-circulation-promoting and bowel-relaxing postoperative physiotherapy belt |
| CN107997871A (en) * | 2017-11-27 | 2018-05-08 | 江西珍视明药业有限公司 | A kind of eye-care fever tablet and preparation method |
| CN107997871B (en) * | 2017-11-27 | 2020-09-15 | 江西珍视明药业有限公司 | Eye care heating sheet and preparation method thereof |
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Application publication date: 20141001 |