CN105287360A - Medical gel with anti-inflammation and antibacterial effects - Google Patents
Medical gel with anti-inflammation and antibacterial effects Download PDFInfo
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Abstract
The invention discloses a medical gel with anti-inflammation and antibacterial effects. The medical gel is prepared from the following main raw materials by mass: 13 to 17 parts of cassia twig, 8 to 13 parts of myrrh, 6 to 10 parts of dried orange peel, 8 to 16 parts of fructus forsythia, 9 to 13 parts of cape jasmine, 10 to 13 parts of Chinese angelica, 9 to 15 parts of aloe, 8 to 13 parts of honeysuckle flower, 6 to 11 parts of akebia stem, 7 to 15 parts of notopterygium root, 6 to 10 parts of pinellia ternate, 7 to 12 parts of Chinese toona root-bark, 2 to 3 parts of borneol, 18 to 26 parts of polyvinyl alcohol, a proper amount of octanol, a proper amount of propyl p-hydroxybenzoate and a proper amount of sorbitol. The medical gel utilizes natural plant drugs which are scientifically combined together and contain a plurality of anti-inflammation and antibacterial components; and through synergism of all the raw materials, the medical gel has good antibacterial and anti-inflammation effects, is free of irritation to the skin and toxic and side effects, and does not incur allergy.
Description
Technical field
The present invention relates to field of medical materials, especially relate to a kind of medical gel with antiphlogistic antibacterial effect.
Background technology
Gel is also known as frozen glue.Colloidal particle in colloidal sol or solution or macromolecule are connected to each other under certain condition, form space net structure, the liquid be filled with in structural void as disperse medium (also can be gas in xerogel, xerogel is also referred to as aeroge), a kind of so special dispersion is called gel.Do not have mobility, inner normal containing large quantity of fluid, such as the water content of blood clotting glue, agar all can reach more than 99%.Elastic gel and fragility gel can be divided into.After elastic gel loses disperse medium, volume significantly reduces, and when reuptaking disperse medium, volume expands again, such as gelatin etc.When fragility gel loses or reuptakes disperse medium, shape and volume do not change, such as silica gel etc.The process being formed gel by solution or colloidal sol is called gelation.
The gel-like material of medical gel mainly some high-molecular copolymers and the material such as cross-linking agent and deionized water composition, its kind is a lot, may be used for the fields such as medical wound care and skin protection.Such as, replace normal gauze as wound dressing with gel, because the gel state of gel itself, more more soft than normal gauze, the juice of wound can also be absorbed, reduce the probability of wound infection, reduction of patient pain.At present, medical gel series products is mainly used in promoting wound repair and healing or tumor remission patient pain field.
And at present, due to antibiotic extensive use, or even abuse, the generation that result in bacterial drug resistance is accelerated, and the situation that anti-dye treatment faces is also more and more severeer.
In the existing traditional Chinese medical science about in the gel of antiphlogistic antibacterial, publication number CN104306922A(application number 201410522498.8) patent discloses hydrogel of a kind of anti-inflammatory analgetic and preparation method thereof, by mass percentage, its formula comprises following component: the starch of 60-70%, the polyvinylpyrrolidone of 15-23%, 8-12% sodium carboxymethyl cellulose, by enough materials that other component is fully miscible by each component miscibility, it is characterized in that, also comprise 2-8% Chinese medicine ingredients; In the Chinese medicine ingredients of 2-8%, by mass percentage, wherein sulfate glycosamine 20%-40%, chondroitin sulfate 10%-30%, Ramulus Sambuci Williamsii 10-20%, Rhizoma Zingiberis Recens extract 8-12%, Olibanum 5-9%, Myrrha 5-9%, green tea extract 6-10%, Semen Strychni 1-5%.Publication number CN103341106A(application number 201310321728.X) patent discloses a kind of Cordyceps antimicrobial inflammation-relieving gel and preparation method thereof, it is containing, for example lower active ingredient, and its percentage composition is Cordyceps extract 5%-30%, Flos Carthami extract 5%-30%, Radix Sophorae Flavescentis extract 0.5%-20%, Aloe extract 0.5%-20%, Radix Angelicae Sinensis extract 0.5%-10%, Radix Stemonae extract 0.5%-10%, Fructus cnidii extract 0.5%-10%.Publication number CN104922248A(application number 201510318716.0) patent discloses a kind of antibacterial, anti-inflammatory medicine compound gel and preparation method, mainly be made up by ratio of weight and the number of copies of following medicine: Galla Chinensis 10-35, Spina Gleditsiae 10-35, Fructus Cnidii 10-25, Radix Scutellariae 10-30, Herba Sophorae alopecuroidis 5-25, Pedicellus Melo 5-20, Yang Tie blade root 10-25, tea tree ethereal oil 0.8-2, sweetgum leaf essential oil 0.2-1.2, Borneolum Syntheticum 3-10,55% ethanol 5-10, carbomer 0.6-1.5, triethanolamine 8-15, methyl hydroxybenzoate 0.3-1.
The medicine that conventional therapy infects is based on western medicine antibiotics, and life-time service easily causes bacterial resistance, affects the treatment, and larger side effect easily causes the injury of the organs such as liver, produces injury to human body.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of medical gel with antiphlogistic antibacterial effect, selected medicine is natural medicinal plants, compatibility science between each medicine, containing multiple antiinflammatory, antimicrobial component, by the synergism between each raw material, anti-inflammation is effective, have no stimulation to skin, without allergic phenomena with have no side effect.Another object is just to provide the above-mentioned preparation method with the medical gel of antiphlogistic antibacterial effect.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
There is the medical gel of antiphlogistic antibacterial effect, take off the primary raw material stating quality proportioning and be prepared from: Ramulus Cinnamomi 13-17 part, Myrrha 8-13 part, Pericarpium Citri Reticulatae 6-10 part, Fructus Forsythiae 8-16 part, Fructus Gardeniae 9-13 part, Radix Angelicae Sinensis 10-13 part, Aloe 9-15 part, Flos Lonicerae 8-13 part, Caulis Akebiae 6-11 part, Rhizoma Et Radix Notopterygii 7-15 part, Rhizoma Pinelliae 6-10 part, Cortex toonae sinensis radicis 7-12 part, Borneolum Syntheticum 2-3 part, polyvinyl alcohol 18-26 part, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
Have the medical gel of antiphlogistic antibacterial effect, preferred scheme is, takes off the primary raw material stating quality proportioning and is prepared from: Ramulus Cinnamomi 14-16 part, Myrrha 10-12 part, Pericarpium Citri Reticulatae 7-9 part, Fructus Forsythiae 11-13 part, Fructus Gardeniae 10-12 part, Radix Angelicae Sinensis 11-12 part, Aloe 11-13 part, Flos Lonicerae 10-12 part, Caulis Akebiae 8-10 part, Rhizoma Et Radix Notopterygii 10-12 part, Rhizoma Pinelliae 7-9 part, Cortex toonae sinensis radicis 9-11 part, Borneolum Syntheticum 2.3-2.7 part, polyvinyl alcohol 20-24 part, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
Have the medical gel of antiphlogistic antibacterial effect, the scheme be more preferably is, takes off the primary raw material stating quality proportioning and is prepared from: Ramulus Cinnamomi 15 parts, Myrrha 11 parts, Pericarpium Citri Reticulatae 8 parts, Fructus Forsythiae 12 parts, Fructus Gardeniae 11 parts, Radix Angelicae Sinensis 11.5 parts, Aloe 12 parts, Flos Lonicerae 11 parts, Caulis Akebiae 9 parts, Rhizoma Et Radix Notopterygii 11 parts, the Rhizoma Pinelliae 8 parts, Cortex toonae sinensis radicis 10 parts, Borneolum Syntheticum 2.5 parts, polyvinyl alcohol 22 parts, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
The above-mentioned preparation method with the medical gel of antiphlogistic antibacterial effect, step is as follows:
(1) Ramulus Cinnamomi, Fructus Forsythiae, Fructus Gardeniae and the Rhizoma Pinelliae are placed in frying pan, moderate heat parch 20-30 minute, take out, dry in the air cool, be ground into fine powder altogether together with Myrrha and Aloe, cross 140-160 mesh sieve;
(2) by Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii section, be placed in container, add rice wine, moistening 5-8 hour, puts into pot, the pot that upper cover one is less, two pots of junction yellow mud sealing, pressure one weight on lid pot, and it is saturating that intense fire adds forged, takes out, cools;
(3) Pericarpium Citri Reticulatae, Flos Lonicerae, Caulis Akebiae and Cortex toonae sinensis radicis are placed in marmite, decoct with water 20-30 minute, add step (2) gains, continue decoction twice, each decoction 30-40 minute, filters, merging filtrate, add step (1) gained medicated powder, stir 3-5 minute, adding second acid for adjusting pH is 2.8-3.6, leave standstill 2-4 hour, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
(4) polyvinyl alcohol is ground into fine powder, inserts in blender, add purified water, stir evenly, slowly add medicinal liquid 1 while stirring, adding second acid for adjusting pH is 2.5-3.5, leaves standstill 3-6 hour;
(5) Borneolum Syntheticum is placed in 50%-60% ethanol, is constantly stirred to and dissolves completely;
(6) step (5) gained solution is poured in step (4) gained solution, add glycerol and stir into uniform thick liquid;
(7) capryl alcohol, propyl p-hydroxybenzoate and Sorbitol are joined in step (6) gained thick liquid, froth breaking, adjustment pH value is 5.2-6.0, fully stir at the temperature of 85-95 DEG C and become semigel state, degassed, make the medical gel of semi-solid, aseptic sealed packages.
The above-mentioned preparation method with the medical gel of antiphlogistic antibacterial effect, preferred scheme is: step (1) is moderate heat parch 23-27 minute preferably, is more preferably moderate heat parch 25 minutes.
The above-mentioned preparation method with the medical gel of antiphlogistic antibacterial effect, preferred scheme is: step (2) preferably rice wine consumption is the 30%-40% of Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality, be more preferably that rice wine consumption is Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality 35%.
The above-mentioned preparation method with the medical gel of antiphlogistic antibacterial effect, preferred scheme is: it is 3.0-3.4 that step (3) preferably adds second acid for adjusting pH, is more preferably that to add second acid for adjusting pH be 3.2.
The above-mentioned preparation method with the medical gel of antiphlogistic antibacterial effect, preferred scheme is: step (4) preferably mixing speed is 180-260 rev/min, and being more preferably mixing speed is 220 revs/min.
The above-mentioned preparation method with the medical gel of antiphlogistic antibacterial effect, preferred scheme is: step (6) preferable temperature controls at 50-70 DEG C, is more preferably temperature and controls at 60 DEG C.
The above-mentioned preparation method with the medical gel of antiphlogistic antibacterial effect, preferred scheme is: step (7) preferably fully stirs at the temperature of 88-92 DEG C, fully stirs under being more preferably at the temperature of 90 DEG C.
Using method: directly medical gel is applied to infection inflammation place, every day uses 3-5 time, 2 days courses for the treatment of.
Beneficial effect of the present invention is mainly reflected in:
1, selected by medical gel of the present invention, medicine is natural medicinal plants, compatibility science between each medicine, and containing multiple antiinflammatory, antimicrobial component, by the synergism between each raw material, anti-inflammation is effective, effectively can repair the generation that wound suppresses cicatrix.
2, medical gel of the present invention has good biodegradability, can degrade at short notice, not pollute the environment.
3, medical gel of the present invention can make various shape according to different demands, creates good gnotobasis easily to the wound of infection inflammation, easy to use.
4, medical gel of the present invention has good affinity to human body cell, has no stimulation, without allergic phenomena with have no side effect, as Novel external preparation, has broad application prospects in treatment infection inflammation to skin.
5, medical gel of the present invention can solve the problem such as wound pain, infection inflammation comprehensively, and effectively can activate surrounding skin cell and to climb rocks rapidly dermal scaffold, quickly-healing, clinical trial proves that this medical gel is more evident in efficacy than conventional medicine.
6, medical gel of the present invention can improve the compliance of body to medicine, improves infection curative effect, reduces the generation of untoward reaction.In addition, gel production technology is simple, is applicable to industrialization, automated production.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1there is the medical gel of antiphlogistic antibacterial effect, take off and state primary raw material and be prepared from (getting 80g for every part): Ramulus Cinnamomi 13 parts, Myrrha 8 parts, Pericarpium Citri Reticulatae 6 parts, Fructus Forsythiae 8 parts, Fructus Gardeniae 9 parts, Radix Angelicae Sinensis 10 parts, Aloe 9 parts, Flos Lonicerae 8 parts, Caulis Akebiae 6 parts, Rhizoma Et Radix Notopterygii 7 parts, the Rhizoma Pinelliae 6 parts, Cortex toonae sinensis radicis 7 parts, Borneolum Syntheticum 2 parts, polyvinyl alcohol 18 parts, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
The medical gel preparation process with antiphlogistic antibacterial effect is as follows:
(1) Ramulus Cinnamomi, Fructus Forsythiae, Fructus Gardeniae and the Rhizoma Pinelliae are placed in frying pan, moderate heat parch 20 minutes, take out, dry in the air cool, be ground into fine powder altogether together with Myrrha and Aloe, cross 140 mesh sieves;
(2) by Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii section, be placed in container, add rice wine (consumption is 30% of Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality), moistening 5 hours, put into pot, the pot that upper cover one is less, two pots of junction yellow mud sealing, pressure one weight on lid pot, it is saturating that intense fire adds forged, takes out, cool;
(3) Pericarpium Citri Reticulatae, Flos Lonicerae, Caulis Akebiae and Cortex toonae sinensis radicis are placed in marmite, decoct with water 20 minutes, add step (2) gains, continue decoction twice, each decoction 30 minutes, filters, merging filtrate, add step (1) gained medicated powder, stir 3 minutes, adding second acid for adjusting pH is 2.8, leave standstill 2 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
(4) polyvinyl alcohol is ground into fine powder, inserts in blender, add purified water, stir evenly (mixing speed is 180 revs/min), slowly add medicinal liquid 1 while stirring, adding second acid for adjusting pH is 2.5, leaves standstill 3 hours;
(5) Borneolum Syntheticum is placed in 50% ethanol, is constantly stirred to and dissolves completely;
(6) step (5) gained solution is poured in step (4) gained solution, add glycerol and stir into uniform thick liquid (temperature controls at 50 DEG C);
(7) capryl alcohol, propyl p-hydroxybenzoate and Sorbitol are joined in step (6) gained thick liquid, froth breaking, regulate pH value to be 5.2, fully stir at the temperature of 85 DEG C and become semigel state, degassed, make the medical gel of semi-solid, aseptic sealed packages.
Using method: directly medical gel is applied to infection inflammation place, every day uses 3-5 time, 2 days courses for the treatment of.
embodiment 2there is the medical gel of antiphlogistic antibacterial effect, take off and state primary raw material and be prepared from (getting 20g for every part): Ramulus Cinnamomi 17 parts, Myrrha 13 parts, Pericarpium Citri Reticulatae 10 parts, Fructus Forsythiae 16 parts, Fructus Gardeniae 13 parts, Radix Angelicae Sinensis 13 parts, Aloe 15 parts, Flos Lonicerae 13 parts, Caulis Akebiae 11 parts, Rhizoma Et Radix Notopterygii 15 parts, the Rhizoma Pinelliae 10 parts, Cortex toonae sinensis radicis 12 parts, Borneolum Syntheticum 3 parts, polyvinyl alcohol 26 parts, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
The preparation process with the medical gel of antiphlogistic antibacterial effect is as follows:
(1) Ramulus Cinnamomi, Fructus Forsythiae, Fructus Gardeniae and the Rhizoma Pinelliae are placed in frying pan, moderate heat parch 30 minutes, take out, dry in the air cool, be ground into fine powder altogether together with Myrrha and Aloe, cross 160 mesh sieves;
(2) by Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii section, be placed in container, add rice wine (consumption is 40% of Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality), moistening 8 hours, put into pot, the pot that upper cover one is less, two pots of junction yellow mud sealing, pressure one weight on lid pot, it is saturating that intense fire adds forged, takes out, cool;
(3) Pericarpium Citri Reticulatae, Flos Lonicerae, Caulis Akebiae and Cortex toonae sinensis radicis are placed in marmite, decoct with water 30 minutes, add step (2) gains, continue decoction twice, each decoction 40 minutes, filters, merging filtrate, add step (1) gained medicated powder, stir 5 minutes, adding second acid for adjusting pH is 3.6, leave standstill 4 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
(4) polyvinyl alcohol is ground into fine powder, inserts in blender, add purified water, stir evenly (mixing speed is 260 revs/min), slowly add medicinal liquid 1 while stirring, adding second acid for adjusting pH is 3.5, leaves standstill 6 hours;
(5) Borneolum Syntheticum is placed in 60% ethanol, is constantly stirred to and dissolves completely;
(6) step (5) gained solution is poured in step (4) gained solution, add glycerol and stir into uniform thick liquid (temperature controls at 70 DEG C);
(7) capryl alcohol, propyl p-hydroxybenzoate and Sorbitol are joined in step (6) gained thick liquid, froth breaking, regulate pH value to be 6.0, fully stir at the temperature of 95 DEG C and become semigel state, degassed, make the medical gel of semi-solid, aseptic sealed packages.
Using method: directly medical gel is applied to infection inflammation place, every day uses 3-5 time, 2 days courses for the treatment of.
model case onetight XX, female, 24 years old, people from Qingdao of Shandong province.Mrs's Yan custom wears high heels, and has walked many often to grind to obtain foot pain, sometimes all can limp on foot, generally pasted adhesive bandage soon just good.And once relatively more serious, foot back galls skin, and forefoot is so squeezed that to play multiple blister, Mrs Yan is according to equally having pasted adhesive bandage habitually in the past, but discovery foot swelling of waking up from a sleep for second day, instep is especially obvious, some blisters break, infection inflammation, even have pus to ooze out.
After using the present invention to have 2 courses for the treatment of of medical gel (embodiment 2) of antiphlogistic antibacterial effect, infection inflammation place, without pain, continues to ooze out without pus.After continuing 2 courses for the treatment of of use, there is sense of itching wound, and foot's swelling disappears, and infection inflammation place skin recovers better.Visit after two weeks and learn and fully recover, do not occur signs of inflammation again.
embodiment 3there is the medical gel of antiphlogistic antibacterial effect, take off and state primary raw material and be prepared from (getting 50g for every part): Ramulus Cinnamomi 14 parts, Myrrha 10 parts, Pericarpium Citri Reticulatae 7 parts, Fructus Forsythiae 11 parts, Fructus Gardeniae 10 parts, Radix Angelicae Sinensis 11 parts, Aloe 11 parts, Flos Lonicerae 10 parts, Caulis Akebiae 8 parts, Rhizoma Et Radix Notopterygii 10 parts, the Rhizoma Pinelliae 7 parts, Cortex toonae sinensis radicis 9 parts, Borneolum Syntheticum 2.3 parts, polyvinyl alcohol 20 parts, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
The medical gel preparation process with antiphlogistic antibacterial effect is as follows:
(1) Ramulus Cinnamomi, Fructus Forsythiae, Fructus Gardeniae and the Rhizoma Pinelliae are placed in frying pan, moderate heat parch 23 minutes, take out, dry in the air cool, be ground into fine powder altogether together with Myrrha and Aloe, cross 140 mesh sieves;
(2) by Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii section, be placed in container, add rice wine (consumption is 33% of Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality), moistening 6 hours, put into pot, the pot that upper cover one is less, two pots of junction yellow mud sealing, pressure one weight on lid pot, it is saturating that intense fire adds forged, takes out, cool;
(3) Pericarpium Citri Reticulatae, Flos Lonicerae, Caulis Akebiae and Cortex toonae sinensis radicis are placed in marmite, decoct with water 23 minutes, add step (2) gains, continue decoction twice, each decoction 33 minutes, filters, merging filtrate, add step (1) gained medicated powder, stir 3 minutes, adding second acid for adjusting pH is 3.0, leave standstill 2 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
(4) polyvinyl alcohol is ground into fine powder, inserts in blender, add purified water, stir evenly (mixing speed is 200 revs/min), slowly add medicinal liquid 1 while stirring, adding second acid for adjusting pH is 2.8, leaves standstill 4 hours;
(5) Borneolum Syntheticum is placed in 53% ethanol, is constantly stirred to and dissolves completely;
(6) step (5) gained solution is poured in step (4) gained solution, add glycerol and stir into uniform thick liquid (temperature controls at 55 DEG C);
(7) capryl alcohol, propyl p-hydroxybenzoate and Sorbitol are joined in step (6) gained thick liquid, froth breaking, regulate pH value to be 5.5, fully stir at the temperature of 88 DEG C and become semigel state, degassed, make the medical gel of semi-solid, aseptic sealed packages.
Using method: directly medical gel is applied to infection inflammation place, every day uses 3-5 time, 2 days courses for the treatment of.
embodiment 4there is the medical gel of antiphlogistic antibacterial effect, take off and state primary raw material and be prepared from (getting 30g for every part): Ramulus Cinnamomi 16 parts, Myrrha 12 parts, Pericarpium Citri Reticulatae 9 parts, Fructus Forsythiae 13 parts, Fructus Gardeniae 12 parts, Radix Angelicae Sinensis 12 parts, Aloe 13 parts, Flos Lonicerae 12 parts, Caulis Akebiae 10 parts, Rhizoma Et Radix Notopterygii 12 parts, the Rhizoma Pinelliae 9 parts, Cortex toonae sinensis radicis 11 parts, Borneolum Syntheticum 2.7 parts, polyvinyl alcohol 24 parts, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
The medical gel preparation process with antiphlogistic antibacterial effect is as follows:
(1) Ramulus Cinnamomi, Fructus Forsythiae, Fructus Gardeniae and the Rhizoma Pinelliae are placed in frying pan, moderate heat parch 30 minutes, take out, dry in the air cool, be ground into fine powder altogether together with Myrrha and Aloe, cross 160 mesh sieves;
(2) by Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii section, be placed in container, add rice wine (rice wine consumption is 37% of Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality), moistening 8 hours, put into pot, the pot that upper cover one is less, two pots of junction yellow mud sealing, pressure one weight on lid pot, it is saturating that intense fire adds forged, takes out, cool;
(3) Pericarpium Citri Reticulatae, Flos Lonicerae, Caulis Akebiae and Cortex toonae sinensis radicis are placed in marmite, decoct with water 27 minutes, add step (2) gains, continue decoction twice, each decoction 37 minutes, filters, merging filtrate, add step (1) gained medicated powder, stir 5 minutes, adding second acid for adjusting pH is 3.2, leave standstill 4 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
(4) polyvinyl alcohol is ground into fine powder, inserts in blender, add purified water, stir evenly (mixing speed is 240 revs/min), slowly add medicinal liquid 1 while stirring, adding second acid for adjusting pH is 3.2, leaves standstill 5 hours;
(5) Borneolum Syntheticum is placed in 57% ethanol, is constantly stirred to and dissolves completely;
(6) step (5) gained solution is poured in step (4) gained solution, add glycerol and stir into uniform thick liquid (temperature controls at 65 DEG C);
(7) capryl alcohol, propyl p-hydroxybenzoate and Sorbitol are joined in step (6) gained thick liquid, froth breaking, regulate pH value to be 5.8, fully stir at the temperature of 92 DEG C and become semigel state, degassed, make the medical gel of semi-solid, aseptic sealed packages.
Using method: directly medical gel is applied to infection inflammation place, every day uses 3-5 time, 2 days courses for the treatment of.
model case twopoplar XX, man, 28 years old, people from Heze city of Shandong province.Mr. Yang is the workman of certain construction team, and accidentally by the hit arm of weight dropped from high-altitude in one action, right arm has been drawn the wound of about six or seven centimetres together, and bosom has 1 centimetre nearly, so go to hospital to sew up.But occur wound infection in a couple of days after sewing up, and have pus to flow out, wound healing is poor, hurt like hell.
After using the present invention to have 2 courses for the treatment of of medical gel (embodiment 4) of antiphlogistic antibacterial effect, wound infection phenomenon disappears substantially, and no longer include pus and ooze out, pain also obviously alleviates.After continuing 2 courses for the treatment of of use, Mr. Yang feels to itch in wound, so remove examination in hospital, finds that wound healing is good.Visit subsequently and learn and fully recover and have no adverse reaction during medication.
embodiment 5there is the medical gel of antiphlogistic antibacterial effect, take off and state primary raw material and be prepared from (getting 50g for every part): Ramulus Cinnamomi 15 parts, Myrrha 11 parts, Pericarpium Citri Reticulatae 8 parts, Fructus Forsythiae 12 parts, Fructus Gardeniae 11 parts, Radix Angelicae Sinensis 11.5 parts, Aloe 12 parts, Flos Lonicerae 11 parts, Caulis Akebiae 9 parts, Rhizoma Et Radix Notopterygii 11 parts, the Rhizoma Pinelliae 8 parts, Cortex toonae sinensis radicis 10 parts, Borneolum Syntheticum 2.5 parts, polyvinyl alcohol 22 parts, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
The medical gel preparation process with antiphlogistic antibacterial effect is as follows:
(1) Ramulus Cinnamomi, Fructus Forsythiae, Fructus Gardeniae and the Rhizoma Pinelliae are placed in frying pan, moderate heat parch 25 minutes, take out, dry in the air cool, be ground into fine powder altogether together with Myrrha and Aloe, cross 150 mesh sieves;
(2) by Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii section, be placed in container, add rice wine (consumption is 35% of Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality), moistening 7 hours, put into pot, the pot that upper cover one is less, two pots of junction yellow mud sealing, pressure one weight on lid pot, it is saturating that intense fire adds forged, takes out, cool;
(3) Pericarpium Citri Reticulatae, Flos Lonicerae, Caulis Akebiae and Cortex toonae sinensis radicis are placed in marmite, decoct with water 25 minutes, add step (2) gains, continue decoction twice, each decoction 35 minutes, filters, merging filtrate, add step (1) gained medicated powder, stir 4 minutes, adding second acid for adjusting pH is 3.2, leave standstill 3 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
(4) polyvinyl alcohol is ground into fine powder, inserts in blender, add purified water, stir evenly (mixing speed is 220 revs/min), slowly add medicinal liquid 1 while stirring, adding second acid for adjusting pH is 3.0, leaves standstill 5 hours;
(5) Borneolum Syntheticum is placed in 55% ethanol, is constantly stirred to and dissolves completely;
(6) step (5) gained solution is poured in step (4) gained solution, add glycerol and stir into uniform thick liquid (temperature controls at 60 DEG C);
(7) capryl alcohol, propyl p-hydroxybenzoate and Sorbitol are joined in step (6) gained thick liquid, froth breaking, regulate pH value to be 5.6, fully stir at the temperature of 90 DEG C and become semigel state, degassed, make the medical gel of semi-solid, aseptic sealed packages.
Using method: directly medical gel is applied to infection inflammation place, every day uses 3-5 time, 2 days courses for the treatment of.
The pharmacological effect of each crude drug is respectively:
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature.GUIXIN, lung, urinary bladder channel.For the dry twig of canella Cortex Cinnamomi.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, effect of the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Myrrha: bitter in the mouth, pungent, property is put down.For olive subject plant Herba Violae tree or the dry resin of Ha Didingshu.Gather the white oleo-gum-resin of being oozed out by bark crack, in air, become rufous and hard nahlock.After smashing, fry to coke black and apply.There is promoting blood circulation and stopping pain, effect of detumescence and promoting granulation.For breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.
Pericarpium Citri Reticulatae: another name Pericarpium Citri tangerinae, expensive old, Folium Styracis Suberifoliae, Fructus Citri tangerinae skin, extensively Pericarpium Citri tangerinae etc.Bitter in the mouth, pungent, warm in nature.Return lung, spleen channel.For the dry mature skin of rutaceae orange and variety thereof.There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Fructus Forsythiae: bitter in the mouth, cold in nature.Return lung, the heart, small intestine meridian.For the dry fruit of Oleaceae plants Fructus Forsythiae.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, antibacterial, heart tonifying, diuresis, effect that town is told.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Fructus Gardeniae: bitter in the mouth, cold in nature.GUIXIN, lung, tri-jiao channel.Another name SHANZHIZI etc.For the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.There is pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Radix Angelicae Sinensis: sweet in the mouth, pungent, micro-hardship, warm in nature.Return liver, the heart, spleen channel.For the dry root of umbelliferae angelica.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Aloe: bitter in the mouth, cold in nature.Return liver, stomach, large intestine channel.For liliaceous plant Curacao Lu Ji, Aloe ferox Miller or other belong to the dry product of concentrated juice of kindred plant leaf together.There is removing heat from the liver, effect of relieving constipation.For constipation, infantile malnutrition, infantile convulsion; External treatment exudative dermatitis.
Flos Lonicerae: sweet in the mouth, cold in nature.Return lung, the heart, stomach warp.For the flower that dry flower or the band of caprifoliaceae plant Radix Ophiopogonis are just opened.There is heat-clearing and toxic substances removing, effect of wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat, various febrile disease (as fever of the body, dermexanthesis, sending out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain).
Caulis Akebiae: bitter in the mouth, cold nature.GUIXIN, small intestinal, urinary bladder channel.For the dry rattan of plants of Lardizabalaceae Caulis Akebiae, threeleaf akebia or Caulis Akebiae.There is clearing away heart-fire, diuresis, the effect of stimulating milk secretion of stimulating the menstrual flow.For irritable feverish sensation in the chest, larynx disease pharyngalgia, dark coloured urine, five types of stranguria, edema, whole body spasm and pain, amenorrhea breast is few.
Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature.Return bladder, kidney channel.For dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.There is cold expelling, dispel the wind, dehumidifying, effect of pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
The Rhizoma Pinelliae: acrid in the mouth, warm in nature.Return spleen, stomach, lung meridian.For the dry tuber of the aroid Rhizoma Pinelliae.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and thymus painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.
Cortex toonae sinensis radicis: bitter in the mouth, puckery, cold nature.Return large intestine, stomach warp.For bark or the root bark of Meliaceae plant Tonnae Sinensis.There is heat clearing and damp drying, astringing intestine to stop diarrhea, hemostasis, leukorrhagia stopping, effect of parasite killing.For having loose bowels, dysentery, discharging fresh blood stool, metrorrhagia, leukorrhagia, ascariasis, filaricide, skin ulcer tinea.
Borneolum Syntheticum: acrid in the mouth, hardship, cool in nature.GUIXIN, lung meridian.For the processed goods of Spore density Borneolum Syntheticum resin, or chemically synthesize for Camphora, Lignum Pini Nodi wet goods be processed into product.It is intimate pure dextro Borneolum Syntheticum.Multiple ter penoids is contained in the resin of Borneolum Syntheticum and volatile oil, except Borneolum Syntheticum, still containing sesquiterpenes such as Humuleno, beta-elemene, caryophyllene, the triterpenoids such as oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol.There is logical all keys, loose stagnated fire, removing nebula improving eyesight, effect of reducing swelling and alleviating pain.For apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, order is nebula film also, enterobiasis.
Polyvinyl alcohol: pharmaceutical grade Polyethylene alcohol is a kind of extremely safe macromolecule organic, to human non-toxic, have no side effect, can by Non oil-based route large-scale production, cheap, its oil resistant, solvent resistant and gas barrier property are outstanding, there is good biocompatibility, its aqueous gel being widely used in ophthalmology, wound dressing and artificial joint, simultaneously at polyvinyl alcohol film at medicinal film, also there is use the aspects such as artificial kidney film.Its safety can have some idea of from for wound skin repair and eye eye drop product.In food, drug packaging, there is unique advantage.There is unique strong adherence, epithelium pliability, flatness, oil resistivity, solvent resistance, protecting colloid, gas barrier performance, wearability and resistance to water; therefore except making fibrous raw material; also by a large amount of for the production of products such as coating, binding agent, paper product processing agent, emulsifying agent, dispersant, thin film, range of application is throughout industries such as weaving, food, medicine, building, timber processing, papermaking, printing, agricultural, iron and steel, macromolecule chemical industries.Under the effect of antibacterial and enzyme, 46 days degradables 75%, belong to a kind of Biodegradable polymer material, and it is the excellent pharmaceutic adjuvant again with potentiality to be exploited.
Capryl alcohol: the flammable liquid being colourless special odor, water insoluble, can dissolve each other with most organic solvent.Mainly for the production of plasticizer, extractant, stabilizing agent, as the intermediate of solvent and spice.Be commonly used for plasticizer, defoamer, dispersant, dressing agent and oil compound.In plasticizer field, capryl alcohol generally refers to 2-ethyl hexanol, and this is the bulk raw material of megaton, industrially more valuable more than n-octyl alcohol.Capryl alcohol itself is also used as spice, and blending Flos Rosae Rugosae, the floral perfumes such as Bulbus Lilii, as soap perfume.This Pin Shi China GB2760-86 is defined as the flavorant allowing to use.Main in order to prepare Cortex cocois radicis, Fructus Ananadis comosi, Fructus Persicae, chocolate and Citrus essence, as surfactant, solvent, defoamer, commercial auxiliaries etc.Mainly be used as defoamer in the present invention.
Propyl p-hydroxybenzoate: also known as propylparaben, is mainly used as the antiseptic of food, cosmetics, medicine etc., antioxidant, antibacterial.Mainly play antiseptic in the present invention.Generally obtained by P-hydroxybenzoic acid and normal propyl alcohol esterification.By P-hydroxybenzoic acid and propanol mixing, heating makes dissolving, slowly adds sulphuric acid, cools, pour crystallization in 4% sodium carbonate liquor into after continuing reflux 8h, filters, is washed to neutrality and is crude product, then obtains finished product through ethyl alcohol recrystallization.In preparation, cation exchange resin also can be adopted to replace sulfuric acid catalyst.
Sorbitol: another name sorbitol is white hygroscopic powder or crystalline powder, lamellar or granule, odorless.(1g is dissolved in about 0.45mL water) soluble in water, be insoluble in organic solvent, it is acidproof, and heat resistance is good.Have refrigerant sweet taste, sugariness is about the half of sucrose, and calorific value is close with sucrose.According to regulation in China " food additive use sanitary standard " (GB2760-1996): Sorbitol can be used for popsicle, ice lolly, cake, beverage, cookies, bread, pickles, confection by need of production.In actual production, Sorbitol can be used as nutritive sweeteners, wetting agent, chelating agen and stabilizing agent and uses.Mainly play the effect of correctives in the present invention.
test example 1: in order to verify whether the medical gel (embodiment 5) that the present invention has antiphlogistic antibacterial effect has zest: in August ,-2010 in February, 2010 has done irritation test.
Adopt repeatedly intact skin irritant test method, screen 100 Kunming white mice that skin is intact, body weight is 20-30g, test first 2 days, slough the hair of each about 2cm*2cm in its spinal column both sides, back respectively, the left side that the medical gel that the present invention's preparation has antiphlogistic antibacterial effect is coated in every white mice is taken off plucked skin surface by next day, fixes by non-stimulated medical sterile gauze; Take off on the right side of every white mice the distilled water that plucked skin surface smears equivalent simultaneously, fix by non-stimulated medical sterile gauze equally.Remove sterile gauze after 6 hours, smear once every day, smear 10 days continuously by described method above, period observes the local response of skin and the W-response of health, carries out irritant reaction scoring.
Skin Irritation Test result: adopt repeatedly intact skin irritant test method, tests 100 Kunming white mice, to detect the medical gel with antiphlogistic antibacterial effect prepared by the present invention to the stimulation of laboratory animal skin and intensity.Respectively at observing the local skin reaction of tested white mice spinal column both sides after duration of test and test, observed result is for test white mice both sides skin is all without other malaise symptoms such as red and swollen and erythema, scoring is 0, so the skin irritation strength grading that the present invention has the medical gel of antiphlogistic antibacterial effect is nonirritant rank, can relievedly use.
test example 2: in order to verify that the present invention has the curative effect of the medical gel (embodiment 5) of antiphlogistic antibacterial effect: in July ,-2011 in October, 2010 has done contrast test.
General data: the patient of screening 150 routine infection inflammations, be divided into experimental group and matched group two groups at random, wherein experimental group has 100 people, and matched group has 50 people, two groups of patients no significant difference in age, stadium, the state of an illness etc.Experimental group uses the present invention to have the medical gel of antiphlogistic antibacterial effect, and directly medical gel is applied to infection inflammation place, every day uses 3-5 time, 2 days courses for the treatment of.Matched group uses the medicine of other treatment infection inflammation, and such as use gentamycin to embrocate, every day uses 3-5 time, observes the recovery of patient.
Therapeutic effect, finds through the treatments of 10 days, and use medicine after 3 days, experimental group has infection place of the patient of 63% to be controlled effectively, and without hemorrhage and suppuration phenomenon, and matched group only has the patient of 36% without hemorrhage and suppuration phenomenon; Use medicine after 7 days, the situation of all patients of experimental group has obvious alleviation, wherein the infection inflammation of patient of 83% recovers completely, without suppurating without phenomenons such as rednesses around skin, remaining patient of 17% has the alleviation all had in various degree, and the curative effect of matched group is remarkable, the patient of 50% is only had to have alleviation in various degree.Obviously can find out that the present invention has the curative effect of the medical gel of antiphlogistic antibacterial effect more significantly, antiphlogistic antibacterial better effects if.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. there is the medical gel of antiphlogistic antibacterial effect, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from (being weight portion): Ramulus Cinnamomi 13-17 part, Myrrha 8-13 part, Pericarpium Citri Reticulatae 6-10 part, Fructus Forsythiae 8-16 part, Fructus Gardeniae 9-13 part, Radix Angelicae Sinensis 10-13 part, Aloe 9-15 part, Flos Lonicerae 8-13 part, Caulis Akebiae 6-11 part, Rhizoma Et Radix Notopterygii 7-15 part, Rhizoma Pinelliae 6-10 part, Cortex toonae sinensis radicis 7-12 part, Borneolum Syntheticum 2-3 part, polyvinyl alcohol 18-26 part, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
2. medical gel according to claim 1, it is characterized in that, take off the primary raw material stating quality proportioning to be prepared from (being weight portion): Ramulus Cinnamomi 14-16 part, Myrrha 10-12 part, Pericarpium Citri Reticulatae 7-9 part, Fructus Forsythiae 11-13 part, Fructus Gardeniae 10-12 part, Radix Angelicae Sinensis 11-12 part, Aloe 11-13 part, Flos Lonicerae 10-12 part, Caulis Akebiae 8-10 part, Rhizoma Et Radix Notopterygii 10-12 part, Rhizoma Pinelliae 7-9 part, Cortex toonae sinensis radicis 9-11 part, Borneolum Syntheticum 2.3-2.7 part, polyvinyl alcohol 20-24 part, capryl alcohol is appropriate, propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
3. medical gel according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from (being weight portion): Ramulus Cinnamomi 15 parts, Myrrha 11 parts, Pericarpium Citri Reticulatae 8 parts, Fructus Forsythiae 12 parts, Fructus Gardeniae 11 parts, Radix Angelicae Sinensis 11.5 parts, Aloe 12 parts, Flos Lonicerae 11 parts, Caulis Akebiae 9 parts, Rhizoma Et Radix Notopterygii 11 parts, the Rhizoma Pinelliae 8 parts, Cortex toonae sinensis radicis 10 parts, Borneolum Syntheticum 2.5 parts, polyvinyl alcohol 22 parts, capryl alcohol is appropriate, and propyl p-hydroxybenzoate is appropriate, and Sorbitol is appropriate.
4., according to the preparation method of the arbitrary described medical gel of claim 1-3, it is characterized in that, step is as follows:
(1) Ramulus Cinnamomi, Fructus Forsythiae, Fructus Gardeniae and the Rhizoma Pinelliae are placed in frying pan, moderate heat parch 20-30 minute, take out, dry in the air cool, be ground into fine powder altogether together with Myrrha and Aloe, cross 140-160 mesh sieve;
(2) by Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii section, be placed in container, add rice wine, moistening 5-8 hour, puts into pot, the pot that upper cover one is less, two pots of junction yellow mud sealing, pressure one weight on lid pot, and it is saturating that intense fire adds forged, takes out, cools;
(3) Pericarpium Citri Reticulatae, Flos Lonicerae, Caulis Akebiae and Cortex toonae sinensis radicis are placed in marmite, decoct with water 20-30 minute, add step (2) gains, continue decoction twice, each decoction 30-40 minute, filters, merging filtrate, add step (1) gained medicated powder, stir 3-5 minute, adding second acid for adjusting pH is 2.8-3.6, leave standstill 2-4 hour, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
(4) polyvinyl alcohol is ground into fine powder, inserts in blender, add purified water, stir evenly, slowly add medicinal liquid 1 while stirring, adding second acid for adjusting pH is 2.5-3.5, leaves standstill 3-6 hour;
(5) Borneolum Syntheticum is placed in 50%-60% ethanol, is constantly stirred to and dissolves completely;
(6) step (5) gained solution is poured in step (4) gained solution, add glycerol and stir into uniform thick liquid;
(7) capryl alcohol, propyl p-hydroxybenzoate and Sorbitol are joined in step (6) gained thick liquid, froth breaking, adjustment pH value is 5.2-6.0, fully stir at the temperature of 85-95 DEG C and become semigel state, degassed, make the medical gel of semi-solid, aseptic sealed packages.
5. preparation method according to claim 4, is characterized in that: step (1) is moderate heat parch 23-27 minute preferably, is more preferably moderate heat parch 25 minutes.
6. preparation method according to claim 4, is characterized in that: step (2) preferably rice wine consumption is the 30%-40% of Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality, be more preferably that rice wine consumption is Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii quality 35%.
7. preparation method according to claim 4, is characterized in that: it is 3.0-3.4 that step (3) preferably adds second acid for adjusting pH, is more preferably that to add second acid for adjusting pH be 3.2.
8. preparation method according to claim 4, is characterized in that: step (4) preferably mixing speed is 180-260 rev/min, and being more preferably mixing speed is 220 revs/min.
9. preparation method according to claim 4, is characterized in that: step (6) preferable temperature controls at 50-70 DEG C, is more preferably temperature and controls at 60 DEG C.
10. preparation method according to claim 4, is characterized in that: step (7) preferably fully stirs at the temperature of 88-92 DEG C, fully stirs under being more preferably at the temperature of 90 DEG C.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105617455A (en) * | 2016-03-30 | 2016-06-01 | 吴美燕 | Preparation method of Chinese herbal woundplast ointment |
| CN106072913A (en) * | 2016-07-15 | 2016-11-09 | 赵敏 | There is the mask filter disc of antibacterial functions |
| CN112675287A (en) * | 2021-01-28 | 2021-04-20 | 山东华中生物科技有限公司 | Gel composition for men, gel and preparation method of gel |
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| CN1883592A (en) * | 2006-05-31 | 2006-12-27 | 王丽娟 | Gel for treating rheumatism and headache and method for preparing same |
| CN101580618A (en) * | 2009-06-24 | 2009-11-18 | 宜兴市高拓高分子材料有限公司 | Polyvinyl alcohol film and preparation method thereof |
| CN104368031A (en) * | 2014-11-07 | 2015-02-25 | 苏州维泰生物技术有限公司 | Medical antibacterial dressing and preparation method thereof |
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| CN1883592A (en) * | 2006-05-31 | 2006-12-27 | 王丽娟 | Gel for treating rheumatism and headache and method for preparing same |
| CN101580618A (en) * | 2009-06-24 | 2009-11-18 | 宜兴市高拓高分子材料有限公司 | Polyvinyl alcohol film and preparation method thereof |
| CN104368031A (en) * | 2014-11-07 | 2015-02-25 | 苏州维泰生物技术有限公司 | Medical antibacterial dressing and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105617455A (en) * | 2016-03-30 | 2016-06-01 | 吴美燕 | Preparation method of Chinese herbal woundplast ointment |
| CN106072913A (en) * | 2016-07-15 | 2016-11-09 | 赵敏 | There is the mask filter disc of antibacterial functions |
| CN112675287A (en) * | 2021-01-28 | 2021-04-20 | 山东华中生物科技有限公司 | Gel composition for men, gel and preparation method of gel |
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