CN112156148A - Preparation method of cataplasm patch and cataplasm patch prepared by same - Google Patents
Preparation method of cataplasm patch and cataplasm patch prepared by same Download PDFInfo
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- CN112156148A CN112156148A CN202011258489.4A CN202011258489A CN112156148A CN 112156148 A CN112156148 A CN 112156148A CN 202011258489 A CN202011258489 A CN 202011258489A CN 112156148 A CN112156148 A CN 112156148A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses a preparation method of a cataplasm patch, which comprises the following steps: step 1, extracting an extract solution; and 2, refining. The cataplasm prepared by the invention has the advantages of accurate administration dosage, small absorption area, stable and balanced blood concentration, no peak-valley phenomenon, capability of reducing toxic and side effects, no toxicity, no stimulation, no allergy, quick and lasting effect, comfortable and convenient use, convenient operation and the like. The invention also discloses a cataplasm patch.
Description
Technical Field
The invention relates to a preparation method of a traditional Chinese medicine patch, in particular to a preparation method of a cataplasm patch. The invention also relates to a cataplasm patch.
Background
In china, cough and asthma are one of the major symptoms of the pulmonary system, which include bronchial asthma, chronic bronchitis, chronic obstructive pulmonary disease, pulmonary heart disease, interstitial lung disease and other pulmonary disorders.
According to the study of Zhongbingwei, Yuanhuqing and Wanghhetian published in the Chinese medicine forum 2008 5(8) 1070, 1072, the foundation for treating cough and asthma disease by 'winter disease cured in summer' is explored from 'Tianren correspondence', 'preventive treatment' theory, and the study of Zhongbingwei and the like considers that the cough and asthma disease has the main characteristics that: repeated attack and progressive aggravation, most diseases are caused for the whole life, long-term treatment is needed, and a large amount of manpower and financial resources are consumed; while treatment in remission is essential. According to the theory of 'preventive treatment of disease' in traditional Chinese medicine, the cough and asthma disease is treated by applying the acupoint application for treating winter disease in summer, the traditional Chinese medicine and western medicine are clinically good in curative effect and irreplaceable in other traditional Chinese and western medicine treatment methods.
Western asthma is equivalent to the asthma syndrome of traditional Chinese medicine. Traditional Chinese medicine considers that asthma is caused by phlegm retention in the lung due to factors such as exogenous pathogenic factors, improper diet, emotional disorder, physical weakness and overstrain, and the like, so that the phlegm is obstructed in the airway and the lung qi is disordered and descends. According to the content disclosed in practical Chinese medical clinical diagnosis and treatment requirements published by Shanghai science and technology publishers 2008, researches on Lemna minor and the like believe that the prevention and treatment principle of asthma is mainly treating the symptoms in the attack stage, expelling pathogenic factors, calming the asthma and determining the asthma; the remission stage mainly treats the root cause, and the methods of tonifying lung, strengthening spleen, tonifying kidney and the like are respectively adopted to play the roles of strengthening body resistance and consolidating the constitution. Elimination of the "obstinate root" and reduction, alleviation and control of its attack are the primary goals in the treatment of asthma.
According to the 'summer treatment and prevention and treatment of cough and asthma disease' of winter disease disclosed in the 'Chinese medical journal' 2006, No. 5(6) and No. 55-56 pages of the paper by Wang Jiahui, the treatment of bronchial asthma, chronic bronchitis and other lung diseases by applying traditional Chinese medicines to acupuncture points is summarized and considered to follow the principle of 'no treatment of existing diseases and no treatment of diseases' in the 'Nei Jing', take prevention as a main part and combine prevention and treatment, and adopt a 'summer treatment' method of winter disease according to the 'theory of nourishing yang in spring and summer and nourishing yin in autumn and winter' in the 'Nei Jing'.
Modern medical research shows that the pathological reflex area of respiratory system diseases is near the parasympathetic nerve of the thoracic vertebrae of the back, and acupuncture points distributed in the pathological reflex area have obvious curative effect on treating lung diseases. Through application, firstly, the medicine can circulate the meridians to reach corresponding viscera, so that the medicine has the effects of tonifying deficiency and eliminating evil on the lung, the spleen and the kidney, secondly, the qi activity of the affiliated meridians can be regulated, the qi and blood circulation is smooth, and thirdly, the effect like acupuncture can be realized through local compression stimulation of the medicine. Therefore, Feishu and Gaoshan on the back near the thoracic vertebrae are often used for the application therapy. According to the study on the 'research progress of the three-volt-day acupuncture point application therapy for preventing and treating the cough and asthma disease' in the 'journal of traditional Chinese medicine literature' 2010, No. 1, No. 4, and pages 55-57 of Zhang Asia, Chenghua and other researches, the three-volt-day acupuncture point application therapy is a characteristic treatment means of the traditional Chinese medicine for preventing and treating the cough and asthma disease under the guidance of the concept of 'treating winter disease in summer', and has unique advantages. According to the principle of "all kinds of fistula, dyspnea and vomiting" in Nei Jing, the disease of cough and dyspnea is located in the lung, but the shoulder and back are connected to the lung, so that the herbs can enter the lung through Shu acupoints on the shoulder and back.
In conclusion, the acupoint application therapy is adopted to treat the cough and asthma in summer, and is a more effective clinical therapy for preventing and treating the cough and asthma at present. However, the currently used application prescriptions for summer treatment of winter diseases are all processed and used manually. The method comprises the steps of mixing the traditional Chinese medicine decoction pieces, grinding the mixture into powder, adding the fresh ginger juice, uniformly stirring, manually rubbing the mixture into pills with a specific size, and sticking the pills to a specific acupuncture point through the plaster. The difficulty of the method is that the fresh ginger juice is added, so the ginger juice is required to be used at present, is not easy to be preserved for a long time, and is time-consuming to operate in the application process. Therefore, the traditional Chinese medicine composition is difficult to popularize in clinical practice, so that a large number of patients cannot really benefit from the treatment and still suffer from cough and asthma, and the life quality of the patients is greatly influenced.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a preparation method of a cataplasm patch, which can be used for acupoint application therapy to treat cough and asthma in winter in summer.
In order to solve the technical problems, the technical scheme of the preparation method of the cataplasm patch provided by the invention is that the preparation method comprises the following steps:
step 1, extracting an extract solution;
step 1.1, preparing main materials;
stir-frying white mustard seed, prepared euphorbia kansui, rhizoma corydalis, asarum, bulbus fritilariae, stir-fried perilla fruit and safflower, wherein the weight parts are 4-8: 1-5: 4-8: 1-5: 0.5-4: 1-5: 1-5 as raw materials;
step 1.2, decocting the raw materials;
adding the raw materials into an extraction pot, and decocting twice to obtain a primary extract and a secondary extract;
in another embodiment, the decocting method of step 1.2 comprises: firstly, adding water in an amount which is 10 times of the weight of the raw materials into an extraction pot containing the raw materials, boiling for 1.5 +/-0.5 hours, and pouring out liquid in the extraction pot to obtain primary extracting solution; then adding water in an amount which is 8 times of the weight of the raw materials into an extraction pot, boiling for 1 +/-0.5 hours, and pouring out the obtained liquid to obtain a secondary extracting solution.
Step 1.3, primary concentration;
mixing the primary extract and the secondary extract obtained in the step 1.2, and then concentrating the extracts to obtain a concentrated solution with the relative density of 1.10 +/-0.10;
step 1.4, alcohol precipitation;
cooling the concentrated solution to 30 +/-5 ℃, then gradually adding ethanol with the volume percentage concentration of 95 +/-2% into the concentrated solution, measuring the alcohol content of the liquid while adding the ethanol until the alcohol content of the liquid reaches 50-60%, and stopping adding the ethanol;
step 1.5, secondary concentration;
standing the liquid for 24 +/-2 hours, sucking supernatant, and concentrating the supernatant until the relative density is 1.10 +/-0.10 to obtain an extract solution;
step 2, refining;
step 2.1, auxiliary materials are prepared;
preparing a gelatin solution: taking 35-45 parts by weight of gelatin and 15-25 parts by weight of polyvinyl alcohol, adding purified water to dissolve, heating to a temperature not higher than 65 ℃, and stirring to obtain a gelatin solution;
preparing a tartaric acid solution: adding 45-55 parts by weight of tartaric acid into purified water to dissolve, so as to obtain a tartaric acid solution;
preparing a sorbitol mixed solution: taking 450-550 parts by weight of sorbitol and 55-65 parts by weight of kaolin, and stirring and mixing to obtain a sorbitol mixed solution;
preparing a composite aluminum salt mixed solution: taking 3-7 parts by weight of composite aluminum salt, 125-155 parts by weight of sodium polyacrylate, 45-55 parts by weight of sodium carboxymethyl cellulose and 450-550 parts by weight of glycerol, and mixing to obtain a composite aluminum salt mixed solution;
preparing an extract mixed solution: mixing the extract obtained in the step 1 with 625-655 parts by weight of fresh ginger juice to obtain extract mixed liquor;
step 2.2, preparing paste;
putting the gelatin solution obtained in the step 2.1 and the extract mixed solution obtained in the step 2.1 into a mixer; starting the mixer, adding the sorbitol mixed solution obtained in the step 2.1 into the mixer, and stirring for 5 +/-1 seconds; before stirring, purified water is adopted to wash a container containing the mixed solution of the gelatin solution and the extract, and then the washing solution is poured into a mixer so as to avoid wasting the mixed solution of the gelatin solution and the extract;
pouring the tartaric acid solution obtained in the step 2.1 into a mixer, stirring for 30 +/-5 seconds, adding purified water, controlling the total weight of the liquid in the mixer to be 1880-1930 parts by weight, and continuously stirring for 30 +/-5 seconds;
then adding the composite aluminum salt mixed solution obtained in the step 2.1 to ensure that the total weight of the liquid in the mixer does not exceed 2650 parts by weight, stirring for 3 +/-1 min, and stopping for 8 +/-2 min; opening a top cover of the mixing machine during shutdown, scraping off the paste splashed on the inner wall of the cover and the inner wall of the machine, and then closing the cover;
then starting the machine again to stir for 3 +/-1 minutes and discharging to obtain paste;
step 2.3, coating;
in another embodiment, the step 2.3 coating method is: and (3) inputting the paste into a coating machine, coating the paste on a back lining through the coating machine, and covering the surface of the paste with an anti-mucous membrane to obtain a paste sheet.
In another embodiment, the backing is made of non-woven fabric or stretch cloth.
And 2.4, ripening.
In another embodiment, the method of aging in step 2.4 is: placing the paste sheet tray filled with the paste sheets into a curing chamber, wherein the relative humidity in the curing chamber is more than 90%, and the temperature is controlled between 30 and 40 ℃; storing the paste pieces in a ripening chamber for 2 +/-0.5 hours to obtain the finished cataplasm patch.
In another embodiment, in the step 1.1, the main materials include stir-fried white mustard seed, prepared euphorbia kansui root, rhizoma corydalis, asarum, bulbus fritilariae, stir-fried perilla fruit and safflower in a proportion of 6 parts by weight: 3: 6: 3: 2: 3: 3.
in another embodiment, in the auxiliary materials prepared in step 2.1, 40 parts by weight of gelatin, 20 parts by weight of polyvinyl alcohol, 50 parts by weight of tartaric acid, 500 parts by weight of sorbitol, 60 parts by weight of kaolin, 5 parts by weight of composite aluminum salt, 140 parts by weight of sodium polyacrylate, 50 parts by weight of sodium carboxymethylcellulose, 500 parts by weight of glycerol and 640 parts by weight of fresh ginger juice are included.
The invention also provides a cataplasm patch, which comprises the following technical scheme:
a backing;
a paste coated on the backing; and
the anti-sticking film is covered on the surface of the paste;
the paste is prepared by the following steps:
step 1, extracting an extract solution;
step 1.1, preparing main materials;
stir-frying white mustard seed, prepared euphorbia kansui, rhizoma corydalis, asarum, bulbus fritilariae, stir-fried perilla fruit and safflower, wherein the weight parts are 4-8: 1-5: 4-8: 1-5: 0.5-4: 1-5: 1-5 as raw materials;
step 1.2, decocting the raw materials;
adding the raw materials into an extraction pot, and decocting twice to obtain a primary extract and a secondary extract;
step 1.3, primary concentration;
mixing the primary extract and the secondary extract obtained in the step 1.2, and then concentrating the extracts to obtain a concentrated solution with the relative density of 1.10 +/-0.10;
step 1.4, alcohol precipitation;
cooling the concentrated solution to 30 +/-5 ℃, then gradually adding ethanol with the volume percentage concentration of 95 +/-2% into the concentrated solution, measuring the alcohol content of the liquid while adding the ethanol until the alcohol content of the liquid reaches 50-60%, and stopping adding the ethanol;
step 1.5, secondary concentration;
standing the liquid for 24 +/-2 hours, sucking supernatant, and concentrating the supernatant until the relative density is 1.10 +/-0.10 to obtain an extract solution;
step 2, refining;
step 2.1, auxiliary materials are prepared;
preparing a gelatin solution: taking 35-45 parts by weight of gelatin and 15-25 parts by weight of polyvinyl alcohol, adding purified water to dissolve, heating to a temperature not higher than 65 ℃, and stirring to obtain a gelatin solution;
preparing a tartaric acid solution: adding 45-55 parts by weight of tartaric acid into purified water to dissolve, so as to obtain a tartaric acid solution;
preparing a sorbitol mixed solution: taking 450-550 parts by weight of sorbitol and 55-65 parts by weight of kaolin, and stirring and mixing to obtain a sorbitol mixed solution;
preparing a composite aluminum salt mixed solution: taking 3-7 parts by weight of composite aluminum salt, 125-155 parts by weight of sodium polyacrylate, 45-55 parts by weight of sodium carboxymethyl cellulose and 450-550 parts by weight of glycerol, and mixing to obtain a composite aluminum salt mixed solution;
preparing an extract mixed solution: mixing the extract obtained in the step 1 with 625-655 parts by weight of fresh ginger juice to obtain extract mixed liquor;
step 2.2, preparing paste;
putting the gelatin solution obtained in the step 2.1 and the extract mixed solution obtained in the step 2.1 into a mixer; starting the mixer, adding the sorbitol mixed solution obtained in the step 2.1 into the mixer, and stirring for 5 +/-1 seconds; before stirring, purified water is adopted to wash a container containing the mixed solution of the gelatin solution and the extract, and then the washing solution is poured into a mixer so as to avoid wasting the mixed solution of the gelatin solution and the extract;
pouring the tartaric acid solution obtained in the step 2.1 into a mixer, stirring for 30 +/-5 seconds, adding purified water, controlling the total weight of the liquid in the mixer to be 1880-1930 parts by weight, and continuously stirring for 30 +/-5 seconds;
then adding the composite aluminum salt mixed solution obtained in the step 2.1 to ensure that the total weight of the liquid in the mixer does not exceed 2650 parts by weight, stirring for 3 +/-1 min, and stopping for 8 +/-2 min; opening a top cover of the mixing machine during shutdown, scraping off the paste splashed on the inner wall of the cover and the inner wall of the machine, and then closing the cover;
then starting the machine again to stir for 3 +/-1 minutes, and discharging to obtain the paste.
In another embodiment, the backing is made of non-woven fabric or stretch cloth.
In another embodiment, in the step 1.1, the main materials include stir-fried white mustard seed, prepared euphorbia kansui root, rhizoma corydalis, asarum, bulbus fritilariae, stir-fried perilla fruit and safflower in a proportion of 6 parts by weight: 3: 6: 3: 2: 3: 3.
in another embodiment, in the auxiliary materials prepared in step 2.1, 40 parts by weight of gelatin, 20 parts by weight of polyvinyl alcohol, 50 parts by weight of tartaric acid, 500 parts by weight of sorbitol, 60 parts by weight of kaolin, 5 parts by weight of composite aluminum salt, 140 parts by weight of sodium polyacrylate, 50 parts by weight of sodium carboxymethylcellulose, 500 parts by weight of glycerol and 640 parts by weight of fresh ginger juice are included.
The invention can achieve the technical effects that:
compared with the traditional Chinese medicine patch, the cataplasm patch prepared by the invention is used as an external emplastrum, and after medicinal material extracts, medicinal materials or/and chemical medicaments are mixed with a proper hydrophilic matrix, a high polymer matrix material can better absorb and bear the traditional Chinese medicine extract containing various water-soluble and fat-soluble components, and the traditional Chinese medicine extract is subjected to gelation molding. The medicine matrix contains 40-70% of water, has strong moisture retention and good compatibility with skin, so that the structure is like a medicine storehouse and can quickly and durably release the active ingredients contained in the matrix. The cataplasm prepared by the invention has the advantages of accurate administration dosage, small absorption area, stable and balanced blood concentration, no peak-valley phenomenon, capability of reducing toxic and side effects, no toxicity, no stimulation, no allergy, quick and lasting effect, comfortable and convenient use, convenient operation and the like.
The cataplasm patch prepared by the invention is an external patch taking water-soluble high molecular polymer as a matrix framework material, and consists of a back lining, a paste and a mucous membrane.
Compared with the traditional manual pill making mode, the cataplasm patch has stable preparation process and flow during processing, the product stability is higher, and the preparation is more efficient; when in use, the utility model is more convenient and efficient; in the aspect of economic benefit, the product can be not only limited to be used in hospitals but also widely popularized and used in the market through mature processes and manufacturing flows, so that the pain of more patients can be relieved.
Drawings
It is to be understood by those skilled in the art that the following description is only exemplary of the principles of the present invention, which may be applied in numerous ways to achieve many different alternative embodiments. These descriptions are made for the purpose of illustrating the general principles of the present teachings and are not meant to limit the inventive concepts disclosed herein.
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with the general description given above and the detailed description of the drawings given below, serve to explain the principles of the invention.
The invention is described in further detail below with reference to the following figures and detailed description:
FIG. 1 is a schematic flow diagram of a method of making a cataplasm patch of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the drawings of the embodiments of the present invention. It is to be understood that the embodiments described are only a few embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the invention without any inventive step, are within the scope of protection of the invention. Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this invention belongs. As used herein, the terms "first," "second," and the like, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. The word "comprising" and similar words are intended to mean that the elements or items listed before the word cover the elements or items listed after the word and their equivalents, without excluding other elements or items.
Example 1: the preparation method of the cataplasm patch comprises the following steps:
step 1, extracting an extract solution;
step 1.1, batching;
taking 6 g of fried white mustard seed, 3g of prepared euphorbia kansui, 6 g of rhizoma corydalis, 3g of asarum, 2 g of bulbus fritilariae, 3g of fried perilla fruit and 3g of safflower as raw materials;
step 1.2, decocting the raw materials;
decocting the raw materials in an extraction pot; the decocting method comprises the following steps: firstly, adding water with the weight 10 times of that of the raw materials into an extraction pot, boiling for 1.5 hours, and pouring out liquid in the extraction pot to obtain primary extracting solution; then adding water in an amount which is 8 times of the weight of the raw materials into an extraction pot, boiling for 1 hour, and pouring out the obtained liquid to obtain a secondary extracting solution;
step 1.3, primary concentration;
mixing the primary extract and the secondary extract obtained in the step 1.2, and then concentrating the extracts to obtain a concentrated solution with the relative density (namely the density ratio of the concentrated extract to water) of about 1.10;
step 1.4, alcohol precipitation;
cooling the concentrated solution to about 30 ℃, adding 95 vol% ethanol into the concentrated solution, measuring the ethanol content of the solution while adding ethanol until the ethanol content of the solution reaches 55%, and stopping adding ethanol;
step 1.5, secondary concentration;
standing the liquid for 24 hours, sucking supernatant, and concentrating the supernatant until the relative density is about 1.10 to obtain an extract solution;
step 2, refining;
step 2.1, batching;
preparing a gelatin solution: dissolving 40g of gelatin and 20g of polyvinyl alcohol in purified water, heating, and stirring to obtain a gelatin solution;
preparing a tartaric acid solution: 50g of tartaric acid is taken and added with purified water for dissolving to obtain tartaric acid solution;
preparing a sorbitol mixed solution: taking 500g of sorbitol and 60g of kaolin, and stirring and mixing to obtain a sorbitol mixed solution;
preparing a composite aluminum salt mixed solution: taking 5g of composite aluminum salt, 140g of sodium polyacrylate, 50g of sodium carboxymethylcellulose and 500g of glycerol, and mixing to obtain composite aluminum salt mixed solution;
preparing an extract mixed solution: mixing the extract obtained in the step 1 with 640g of fresh ginger juice to obtain extract mixed liquor;
step 2.2, preparing paste;
putting the gelatin solution obtained in the step 2.1 and the extract mixed solution obtained in the step 2.1 into a mixer; starting the mixer, adding the sorbitol mixed solution obtained in the step 2.1 into the mixer, and stirring for 5 seconds; before stirring, purified water is adopted to wash a container containing the mixed solution of the gelatin solution and the extract, and then the washing solution is poured into a mixer so as to avoid wasting the mixed solution of the gelatin solution and the extract;
pouring the tartaric acid solution obtained in the step 2.1 into a mixer, stirring for 30 seconds, adding purified water, controlling the total weight of liquid in the mixer to be 1905 g, and continuously stirring for 30 seconds;
then adding the composite aluminum salt mixed solution obtained in the step 2.1 to ensure that the total weight of liquid in the mixer is not more than 2600 grams, stirring for 3 minutes, and stopping the mixer for 8 minutes; opening a top cover of the mixing machine during shutdown, scraping off the paste splashed on the inner wall of the cover and the inner wall of the machine, and then closing the cover;
then starting the machine again, stirring for 3 minutes, and discharging to obtain paste;
in the process of preparing the ointment, the extract mixed solution as a medicinal material is sequentially mixed with chemical drugs such as gelatin solution, sorbitol mixed solution, tartaric acid solution, composite aluminum salt mixed solution and the like and hydrophilic matrix, a high polymer matrix material can better absorb and bear traditional Chinese medicine extracts comprising a plurality of water-soluble and fat-soluble components, and the traditional Chinese medicine extracts are subjected to gelation molding under the action of the gelatin solution, the prepared ointment is an ointment which takes a water-soluble high polymer as a matrix framework material, contains water up to 40-70 percent, has strong moisture retention and good compatibility with skin, is made to be like a drug library and can quickly and durably release the effective components contained in the matrix.
Step 2.3, coating;
inputting the paste into a coating machine, coating the paste on a backing by the coating machine, and covering an anti-mucous membrane on the surface of the paste to obtain a paste sheet;
the backing can be non-woven fabric, elastic fabric, etc.;
step 2.4, ripening;
placing the paste sheet tray filled with the paste sheets into a curing chamber, wherein the relative humidity in the curing chamber is more than 90%, and the temperature is controlled between 30 and 40 ℃; the patch was stored in a maturation chamber under these conditions for about 2 hours, after which the steam and equipment were turned off and allowed to simmer overnight to give the finished cataplasma.
Example 2: the preparation method of the cataplasm patch comprises the following steps:
step 1, extracting an extract solution;
step 1.1, batching;
taking 4 g of fried white mustard seed, 1 g of prepared euphorbia kansui, 4 g of rhizoma corydalis, 1 g of asarum, 0.5 g of bulbus fritilariae, 1 g of fried perilla seed and 1 g of safflower as raw materials;
step 1.2, decocting the raw materials;
decocting the raw materials in an extraction pot; the decocting method comprises the following steps: firstly, adding water with the weight 10 times of that of the raw materials into an extraction pot, boiling for 1 hour, and pouring out liquid in the extraction pot to obtain primary extracting solution; then adding water in an amount which is 8 times of the weight of the raw materials into an extraction pot, boiling for 0.5 hour, and pouring out the obtained liquid to obtain a secondary extracting solution;
step 1.3, primary concentration;
combining the primary extract and the secondary extract obtained in the step 1.2, and then concentrating the extracts to obtain a concentrated solution with the relative density of about 1.00;
step 1.4, alcohol precipitation;
cooling the concentrated solution to about 25 ℃, adding 93% ethanol by volume into the concentrated solution, measuring the alcohol content of the solution while adding ethanol until the alcohol content of the solution reaches 50%, and stopping adding ethanol;
step 1.5, secondary concentration;
standing the liquid for 22 hours, sucking supernatant, and concentrating the supernatant until the relative density is about 1.00 to obtain an extract solution;
step 2, refining;
step 2.1, batching;
preparing a gelatin solution: taking 35g of gelatin and 15g of polyvinyl alcohol, adding purified water to dissolve, heating and stirring to obtain a gelatin solution;
preparing a tartaric acid solution: adding 45g of tartaric acid into purified water for dissolving to obtain a tartaric acid solution;
preparing a sorbitol mixed solution: taking 450g of sorbitol and 55g of kaolin, and stirring and mixing to obtain a sorbitol mixed solution;
preparing a composite aluminum salt mixed solution: taking 3g of composite aluminum salt, 125g of sodium polyacrylate, 45g of sodium carboxymethylcellulose and 450g of glycerol, and mixing to obtain composite aluminum salt mixed solution;
preparing an extract mixed solution: mixing the extract obtained in the step 1 with 625g of fresh ginger juice to obtain extract mixed liquid;
step 2.2, preparing paste;
putting the gelatin solution obtained in the step 2.1 and the extract mixed solution obtained in the step 2.1 into a mixer; starting the mixer, adding the sorbitol mixed solution obtained in the step 2.1 into the mixer, and stirring for 4 seconds;
then pouring the tartaric acid solution obtained in the step 2.1 into a mixer, stirring for 25 seconds, adding purified water, controlling the total weight of the liquid in the mixer to be 1880 g, and continuing stirring for 25 seconds;
then adding the composite aluminum salt mixed solution obtained in the step 2.1 to ensure that the total weight of the liquid in the mixer is not more than 2650 g, stirring for 2 minutes, and stopping the mixer for 6 minutes; opening a top cover of the mixing machine during shutdown, scraping off the paste splashed on the inner wall of the cover and the inner wall of the machine, and then closing the cover;
then starting the machine again, stirring for 2 minutes, and discharging to obtain paste;
step 2.3, coating;
inputting the paste into a coating machine, coating the paste on a backing by the coating machine, and covering an anti-mucous membrane on the surface of the paste to obtain a paste sheet;
the backing can be non-woven fabric, elastic fabric, etc.;
step 2.4, ripening;
placing the paste sheet tray filled with the paste sheets into a curing chamber, wherein the relative humidity in the curing chamber is more than 90%, and the temperature is controlled between 30 and 40 ℃; the patch was stored in the aging chamber under these conditions for about 1.5 hours, after which the steam and equipment were turned off and allowed to simmer overnight to give the finished cataplasma.
Example 3: the preparation method of the cataplasm patch comprises the following steps:
step 1, extracting an extract solution;
step 1.1, batching;
taking 8 g of fried white mustard seed, 5g of prepared euphorbia kansui, 8 g of rhizoma corydalis, 5g of asarum, 4 g of bulbus fritilariae, 5g of fried perilla fruit and 5g of safflower as raw materials;
step 1.2, decocting the raw materials;
decocting the raw materials in an extraction pot; the decocting method comprises the following steps: firstly, adding water with the weight 10 times of that of the raw materials into an extraction pot, boiling for 2 hours, and pouring out liquid in the extraction pot to obtain primary extracting solution; then adding water in an amount which is 8 times of the weight of the raw materials into an extraction pot, boiling for 1.5 hours, and pouring out the obtained liquid to obtain a secondary extracting solution;
step 1.3, primary concentration;
mixing the primary extract and the secondary extract obtained in the step 1.2, and then concentrating the extracts to obtain a concentrated solution with the relative density of about 1.20;
step 1.4, alcohol precipitation;
cooling the concentrated solution to about 35 ℃, adding 97% ethanol by volume into the concentrated solution, measuring the ethanol content of the solution while adding ethanol until the ethanol content of the solution reaches 60%, and stopping adding ethanol;
step 1.5, secondary concentration;
standing the liquid for 26 hours, sucking supernatant, and concentrating the supernatant until the relative density is about 1.20 to obtain an extract solution;
step 2, refining;
step 2.1, batching;
preparing a gelatin solution: taking 45g of gelatin and 25g of polyvinyl alcohol, adding purified water to dissolve, heating and stirring to obtain a gelatin solution;
preparing a tartaric acid solution: adding 55g of tartaric acid into purified water for dissolving to obtain a tartaric acid solution;
preparing a sorbitol mixed solution: taking 550g of sorbitol and 65g of kaolin, and stirring and mixing to obtain a sorbitol mixed solution;
preparing a composite aluminum salt mixed solution: mixing 7g of composite aluminum salt, 155g of sodium polyacrylate, 55g of sodium carboxymethylcellulose and 550g of glycerol to obtain a composite aluminum salt mixed solution;
preparing an extract mixed solution: mixing the extract obtained in the step 1 with 655g of fresh ginger juice to obtain extract mixed liquor;
step 2.2, preparing paste;
putting the gelatin solution obtained in the step 2.1 and the extract mixed solution obtained in the step 2.1 into a mixer; starting the mixer, adding the sorbitol mixed solution obtained in the step 2.1 into the mixer, and stirring for 6 seconds; before stirring, purified water is adopted to wash a container containing the mixed solution of the gelatin solution and the extract, and then the washing solution is poured into a mixer so as to avoid wasting the mixed solution of the gelatin solution and the extract;
then pouring the tartaric acid solution obtained in the step 2.1 into a mixer, stirring for 35 seconds, adding purified water, controlling the total weight of liquid in the mixer to 1930 g, and continuing stirring for 35 seconds;
then adding the composite aluminum salt mixed solution obtained in the step 2.1 to ensure that the total weight of the liquid in the mixer is not more than 2650 g, stirring for 4 minutes, and stopping the mixer for 10 minutes; opening a top cover of the mixing machine during shutdown, scraping off the paste splashed on the inner wall of the cover and the inner wall of the machine, and then closing the cover;
then starting the machine again, stirring for 4 minutes, and discharging to obtain paste;
step 2.3, coating;
inputting the paste into a coating machine, coating the paste on a backing by the coating machine, and covering an anti-mucous membrane on the surface of the paste to obtain a paste sheet;
the backing can be non-woven fabric, elastic fabric, etc.;
step 2.4, ripening;
placing the paste sheet tray filled with the paste sheets into a curing chamber, wherein the relative humidity in the curing chamber is more than 90%, and the temperature is controlled between 30 and 40 ℃; the patch was stored in the aging chamber under these conditions for about 2.5 hours, after which the steam and equipment were turned off and allowed to simmer overnight to give the finished cataplasma.
It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention cover the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents.
Claims (10)
1. A preparation method of a cataplasm patch is characterized by comprising the following steps:
step 1, extracting an extract solution;
step 1.1, preparing main materials;
stir-frying white mustard seed, prepared euphorbia kansui, rhizoma corydalis, asarum, bulbus fritilariae, stir-fried perilla fruit and safflower, wherein the weight parts are 4-8: 1-5: 4-8: 1-5: 0.5-4: 1-5: 1-5 as raw materials;
step 1.2, decocting the raw materials;
adding the raw materials into an extraction pot, and decocting twice to obtain a primary extract and a secondary extract;
step 1.3, primary concentration;
mixing the primary extract and the secondary extract obtained in the step 1.2, and then concentrating the extracts to obtain a concentrated solution with the relative density of 1.10 +/-0.10;
step 1.4, alcohol precipitation;
cooling the concentrated solution to 30 +/-5 ℃, then gradually adding ethanol with the volume percentage concentration of 95 +/-2% into the concentrated solution, measuring the alcohol content of the liquid while adding the ethanol until the alcohol content of the liquid reaches 50-60%, and stopping adding the ethanol;
step 1.5, secondary concentration;
standing the liquid for 24 +/-2 hours, sucking supernatant, and concentrating the supernatant until the relative density is 1.10 +/-0.10 to obtain an extract solution;
step 2, refining;
step 2.1, auxiliary materials are prepared;
preparing a gelatin solution: taking 35-45 parts by weight of gelatin and 15-25 parts by weight of polyvinyl alcohol, adding purified water to dissolve, heating to a temperature not higher than 65 ℃, and stirring to obtain a gelatin solution;
preparing a tartaric acid solution: adding 45-55 parts by weight of tartaric acid into purified water to dissolve, so as to obtain a tartaric acid solution;
preparing a sorbitol mixed solution: taking 450-550 parts by weight of sorbitol and 55-65 parts by weight of kaolin, and stirring and mixing to obtain a sorbitol mixed solution;
preparing a composite aluminum salt mixed solution: taking 3-7 parts by weight of composite aluminum salt, 125-155 parts by weight of sodium polyacrylate, 45-55 parts by weight of sodium carboxymethyl cellulose and 450-550 parts by weight of glycerol, and mixing to obtain a composite aluminum salt mixed solution;
preparing an extract mixed solution: mixing the extract obtained in the step 1 with 625-655 parts by weight of fresh ginger juice to obtain extract mixed liquor;
step 2.2, preparing paste;
putting the gelatin solution obtained in the step 2.1 and the extract mixed solution obtained in the step 2.1 into a mixer; starting the mixer, adding the sorbitol mixed solution obtained in the step 2.1 into the mixer, and stirring for 5 +/-1 seconds; before stirring, purified water is adopted to wash a container containing the mixed solution of the gelatin solution and the extract, and then the washing solution is poured into a mixer so as to avoid wasting the mixed solution of the gelatin solution and the extract;
pouring the tartaric acid solution obtained in the step 2.1 into a mixer, stirring for 30 +/-5 seconds, adding purified water, controlling the total weight of the liquid in the mixer to be 1880-1930 parts by weight, and continuously stirring for 30 +/-5 seconds;
then adding the composite aluminum salt mixed solution obtained in the step 2.1 to ensure that the total weight of the liquid in the mixer does not exceed 2650 parts by weight, stirring for 3 +/-1 min, and stopping for 8 +/-2 min; opening a top cover of the mixing machine during shutdown, scraping off the paste splashed on the inner wall of the cover and the inner wall of the machine, and then closing the cover;
then starting the machine again to stir for 3 +/-1 minutes and discharging to obtain paste;
step 2.3, coating;
and 2.4, ripening.
2. The method of making a cataplasma of claim 1, wherein the decocting of step 1.2 is: firstly, adding water in an amount which is 10 times of the weight of the raw materials into an extraction pot containing the raw materials, boiling for 1.5 +/-0.5 hours, and pouring out liquid in the extraction pot to obtain primary extracting solution; then adding water in an amount which is 8 times of the weight of the raw materials into an extraction pot, boiling for 1 +/-0.5 hours, and pouring out the obtained liquid to obtain a secondary extracting solution.
3. The method of making a cataplasm of claim 1 wherein the step 2.3 coating method is: and (3) inputting the paste into a coating machine, coating the paste on a back lining through the coating machine, and covering the surface of the paste with an anti-mucous membrane to obtain a paste sheet.
4. The method of manufacturing a cataplasm patch according to claim 1 or 3, wherein the step 2.4 aging method is: placing the paste sheet tray filled with the paste sheets into a curing chamber, wherein the relative humidity in the curing chamber is more than 90%, and the temperature is controlled between 30 and 40 ℃; storing the paste pieces in a ripening chamber for 2 +/-0.5 hours to obtain the finished cataplasm patch.
5. The cataplasm preparation method of claim 1, wherein the ratio of the main materials in step 1.1 to the fried semen brassicae, the prepared euphorbia kansui, the rhizoma corydalis, the asarum, the bulbus fritilariae, the fried perilla fruit and the safflower is 6 parts by weight: 3: 6: 3: 2: 3: 3.
6. the cataplasm patch preparation method of claim 5, wherein the compounding ingredients in step 2.1 include 40 parts by weight of gelatin, 20 parts by weight of polyvinyl alcohol, 50 parts by weight of tartaric acid, 500 parts by weight of sorbitol, 60 parts by weight of kaolin, 5 parts by weight of composite aluminum salt, 140 parts by weight of sodium polyacrylate, 50 parts by weight of sodium carboxymethylcellulose, 500 parts by weight of glycerin and 640 parts by weight of fresh ginger juice.
7. A cataplasm patch characterized by comprising:
a backing;
a paste coated on the backing; and
the anti-sticking film is covered on the surface of the paste;
the paste is prepared by the following steps:
step 1, extracting an extract solution;
step 1.1, preparing main materials;
stir-frying white mustard seed, prepared euphorbia kansui, rhizoma corydalis, asarum, bulbus fritilariae, stir-fried perilla fruit and safflower, wherein the weight parts are 4-8: 1-5: 4-8: 1-5: 0.5-4: 1-5: 1-5 as raw materials;
step 1.2, decocting the raw materials;
adding the raw materials into an extraction pot, and decocting twice to obtain a primary extract and a secondary extract;
step 1.3, primary concentration;
mixing the primary extract and the secondary extract obtained in the step 1.2, and then concentrating the extracts to obtain a concentrated solution with the relative density of 1.10 +/-0.10;
step 1.4, alcohol precipitation;
cooling the concentrated solution to 30 +/-5 ℃, then gradually adding ethanol with the volume percentage concentration of 95 +/-2% into the concentrated solution, measuring the alcohol content of the liquid while adding the ethanol until the alcohol content of the liquid reaches 50-60%, and stopping adding the ethanol;
step 1.5, secondary concentration;
standing the liquid for 24 +/-2 hours, sucking supernatant, and concentrating the supernatant until the relative density is 1.10 +/-0.10 to obtain an extract solution;
step 2, refining;
step 2.1, auxiliary materials are prepared;
preparing a gelatin solution: taking 35-45 parts by weight of gelatin and 15-25 parts by weight of polyvinyl alcohol, adding purified water to dissolve, heating to a temperature not higher than 65 ℃, and stirring to obtain a gelatin solution;
preparing a tartaric acid solution: adding 45-55 parts by weight of tartaric acid into purified water to dissolve, so as to obtain a tartaric acid solution;
preparing a sorbitol mixed solution: taking 450-550 parts by weight of sorbitol and 55-65 parts by weight of kaolin, and stirring and mixing to obtain a sorbitol mixed solution;
preparing a composite aluminum salt mixed solution: taking 3-7 parts by weight of composite aluminum salt, 125-155 parts by weight of sodium polyacrylate, 45-55 parts by weight of sodium carboxymethyl cellulose and 450-550 parts by weight of glycerol, and mixing to obtain a composite aluminum salt mixed solution;
preparing an extract mixed solution: mixing the extract obtained in the step 1 with 625-655 parts by weight of fresh ginger juice to obtain extract mixed liquor;
step 2.2, preparing paste;
putting the gelatin solution obtained in the step 2.1 and the extract mixed solution obtained in the step 2.1 into a mixer; starting the mixer, adding the sorbitol mixed solution obtained in the step 2.1 into the mixer, and stirring for 5 +/-1 seconds; before stirring, purified water is adopted to wash a container containing the mixed solution of the gelatin solution and the extract, and then the washing solution is poured into a mixer so as to avoid wasting the mixed solution of the gelatin solution and the extract;
pouring the tartaric acid solution obtained in the step 2.1 into a mixer, stirring for 30 +/-5 seconds, adding purified water, controlling the total weight of the liquid in the mixer to be 1880-1930 parts by weight, and continuously stirring for 30 +/-5 seconds;
then adding the composite aluminum salt mixed solution obtained in the step 2.1 to ensure that the total weight of the liquid in the mixer does not exceed 2650 parts by weight, stirring for 3 +/-1 min, and stopping for 8 +/-2 min; opening a top cover of the mixing machine during shutdown, scraping off the paste splashed on the inner wall of the cover and the inner wall of the machine, and then closing the cover;
then starting the machine again to stir for 3 +/-1 minutes, and discharging to obtain the paste.
8. The cataplasm patch of claim 7 wherein said backing is a non-woven fabric or a stretch cloth.
9. The cataplasm of claim 7, wherein the ratio of the fried white mustard seed, the prepared euphorbia kansui, the rhizoma corydalis, the asarum, the bulbus fritilariae, the fried perilla seed and the safflower in the main ingredients prepared in the step 1.1 is 6 parts by weight: 3: 6: 3: 2: 3: 3.
10. the cataplasm patch as claimed in claim 7, wherein the compounding ingredients in step 2.1 include 40 parts by weight of gelatin, 20 parts by weight of polyvinyl alcohol, 50 parts by weight of tartaric acid, 500 parts by weight of sorbitol, 60 parts by weight of kaolin, 5 parts by weight of composite aluminum salt, 140 parts by weight of sodium polyacrylate, 50 parts by weight of sodium carboxymethylcellulose, 500 parts by weight of glycerin and 640 parts by weight of fresh ginger juice.
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| CN114983983A (en) * | 2022-06-27 | 2022-09-02 | 中国医学科学院药用植物研究所 | Improved cataplasm and application thereof |
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