CN100457153C - Medicine prepn. for treating acne, and its prepn. method - Google Patents
Medicine prepn. for treating acne, and its prepn. method Download PDFInfo
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- CN100457153C CN100457153C CNB2006100531877A CN200610053187A CN100457153C CN 100457153 C CN100457153 C CN 100457153C CN B2006100531877 A CNB2006100531877 A CN B2006100531877A CN 200610053187 A CN200610053187 A CN 200610053187A CN 100457153 C CN100457153 C CN 100457153C
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- 206010000496 acne Diseases 0.000 title claims abstract description 22
- 239000003814 drug Substances 0.000 title abstract description 17
- 208000002874 Acne Vulgaris Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title description 3
- 229940079593 drug Drugs 0.000 title 1
- 238000001914 filtration Methods 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims description 27
- 241000628997 Flos Species 0.000 claims description 18
- 230000001476 alcoholic effect Effects 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 12
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 9
- 229910000831 Steel Inorganic materials 0.000 claims description 7
- 239000004744 fabric Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 7
- 239000010959 steel Substances 0.000 claims description 7
- 238000007789 sealing Methods 0.000 claims description 6
- 239000000469 ethanolic extract Substances 0.000 claims description 2
- 239000011812 mixed powder Substances 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 abstract description 11
- 238000007873 sieving Methods 0.000 abstract description 6
- 238000002156 mixing Methods 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract 1
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract 1
- 244000247747 Coptis groenlandica Species 0.000 abstract 1
- 235000002991 Coptis groenlandica Nutrition 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 241000207929 Scutellaria Species 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 description 8
- 229920000742 Cotton Polymers 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- 238000000227 grinding Methods 0.000 description 5
- 238000002791 soaking Methods 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 241000863032 Trieres Species 0.000 description 4
- 239000012669 liquid formulation Substances 0.000 description 4
- 238000011017 operating method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 206010048810 Sebaceous hyperplasia Diseases 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 210000004694 pigment cell Anatomy 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000003859 smegma Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine for treating acne is prepared from 9 Chinese-medicinal materials including wild chrysanthemum flower, rhubarb, coptis root, scutellaria root, etc through drying, pulverizing, sieving, mixing, immersing in alcohol solution in sealed mode for 3-15 days, and filtering to obtain liquid medicine.
Description
Technical field
The invention belongs to Chinese medicine extract and preparation technique field thereof, relate to a kind of Chinese medicine preparation extract---comedo preparation and preparation method thereof.
Background technology
Comedo is a kind of dermatosis, be in serious, the happiness of adolescence period of development, oily skin eat the pungent irritable food of fat and sugar based food, because stay up late or job specification with environmental condition and often with the oily crowd's who contacts common skin diseases.The patient is too much because of smegma, a large amount of horny layer come off, after the oils and fats dust and dirt mixes, pore is stopped up, it is inflamed to cause hair follicle, if antibacterial grow in pimples and breeds, then can cause infection, suppuration and forms big pimples, also can make face stay cicatrix when serious, have influence on the attractive in appearance of appearance.The external preparation for skin medicine is in the majority with hormone medicine at present, and life-time service can stimulate sebaceous hyperplasia and pigment cell's hypertrophy, stays the pigmentation spots that is difficult to eliminate or causes corticosteroid dermatitis.
Summary of the invention
At the weak point that exists in the existing comedo technology for eliminating, the invention provides preparation and preparation method that use does not contain the Chinese medicine extract treatment comedo of hormone.Wherein the ratio of weight and number of Chinese medicine is: Flos Chrysanthemi Indici 10-20, Radix Et Rhizoma Rhei 10-20, Rhizoma Coptidis 10-20, Cortex Phellodendri 10-20, Radix Scutellariae 10-20, Radix Salviae Miltiorrhizae 20-30, Flos Lonicerae 25-35, Herba Violae 25-35, Borneolum Syntheticum 2-4.
Comedo preparation of the present invention is a kind of Flos Chrysanthemi Indici 10-20 that contains by weight, Radix Et Rhizoma Rhei 10-20, Rhizoma Coptidis 10-20, Cortex Phellodendri 10-20, Radix Scutellariae 10-20, Radix Salviae Miltiorrhizae 20-30, Flos Lonicerae 25-35, Herba Violae 25-35, the ethanol extract of the whole components of Borneolum Syntheticum 2-4.
The preparation method of described comedo preparation may further comprise the steps:
1) by weight, with exsiccant Flos Chrysanthemi Indici 10-20, Radix Et Rhizoma Rhei 10-20, Rhizoma Coptidis 10-20, Cortex Phellodendri 10-20, Radix Scutellariae 10-20, Radix Salviae Miltiorrhizae 20-30, Flos Lonicerae 25-35, Herba Violae 25-35, Borneolum Syntheticum 2-4 pulverizes the back respectively at pulverizer and sieves with sieve diameter 1mm, and greater than the raw material of 1mm crushing screening again, the collection diameter is less than the powder of 1mm with diameter;
2) pack into after the powder mixes of diameter with above-mentioned whole components sealable glass or rustless steel container less than 1mm, ratio adding concentration according to every liter of alcoholic solution 0.1-2 kilogram mixed-powder is the alcoholic solution of 50-90%, sealing was soaked after 3-15 days, with cloth or filter paper filtering, obtain filtrate and be the comedo preparation.
Said process is summarised as:
1, raw material pulverizing: the dry Chinese medicine of above-mentioned whole components respectively at pulverizer grinding and sieving (sieve diameter 1mm), is collected the powder of diameter less than 1mm; Diameter is pulverized 1 time again greater than the raw material of 1mm also sieve equally, be used for soaking or extracting;
2, extract:, add alcoholic solution, sealing immersion 3-15 days according to the ratio of powder and alcoholic solution 2/1-1/10 kg/liter with the important mixing of above-mentioned pulverizing pack into sealable glass or rustless steel container.With cloth or filter paper filtering, obtain the extracting solution that filtrate is to be needed;
The treatment processing method of comedo preparation of the present invention: with cotton swab said extracted liquid directly is coated in the affected part, be coated with 1-3 every day.3 days 1 courses of treatment.
The present invention is from the characteristics of above-mentioned Chinese medicine extract treatment comedo, and the one, curative effect is fast, handles back 12 hours visual effects; The 2nd, therapeutic effect is remarkable, the treatment effective percentage of 1 course of treatment (naked eyes can find out that affected part swelling obviously reduces, and the processing pox that patient's pain, gargalesthesia obviously reduce is counted and accounted for the ratio that total processing pox is counted) 67-94%; The 3rd, have no side effect.
The specific embodiment
No. 1, embodiment 1, comedo preparation, Chinese medicinal components proportioning and operating procedure are as follows:
1), Chinese medicinal components and proportioning (weight portion) are: Flos Chrysanthemi Indici 15, Radix Et Rhizoma Rhei 15, Rhizoma Coptidis 15, Cortex Phellodendri 15, Radix Scutellariae 15, Radix Salviae Miltiorrhizae 25, Flos Lonicerae 30, Herba Violae 30, Borneolum Syntheticum 3;
2), raw material pulverizing: above-mentioned dry traditional Chinese medicine respectively at pulverizer grinding and sieving (sieve diameter 1mm), is collected the powder of diameter less than 1mm; Diameter is pulverized 1 time again greater than the raw material of 1mm also sieve equally, be used for soaking or extracting;
3), extract: the Chinese medicine mixture of above-mentioned pulverizing pack into sealable glass or rustless steel container, according to the ratio of powder and alcoholic solution 1/3 kg/liter (be every liter of alcoholic solution add 0.3 kilogram mixes Chinese medicinal powder) addings concentration is the alcoholic solution of 60-70% (v/v), seals immersion 10 days.Filter with cloth, collect filtrate as preparation;
4), compliance test result: with cotton swab the said extracted liquid formulation directly is coated in the affected part, is coated with every day 2 times, for three days on end.
Therapeutic effect: trier 8 people (man, each 4 people of woman, age 17-22 year) 36 places, coprocessing affected part, the affected part swelling of 34 place obviously reduces after 1 course of treatment, wherein 29 places symptom complete obiteration, patient's pain, gargalesthesia obviously reduce, treatment effective percentage 94.4%.
No. 2, embodiment 2, comedo preparation, Chinese medicinal components proportioning and operating procedure are as follows:
1), Chinese medicinal components and proportioning (weight portion) are: Flos Chrysanthemi Indici 10, Radix Et Rhizoma Rhei 10, Rhizoma Coptidis 10, Cortex Phellodendri 10, Radix Scutellariae 10, Radix Salviae Miltiorrhizae 20, Flos Lonicerae 25, Herba Violae 25, Borneolum Syntheticum 2;
2), raw material pulverizing: above-mentioned dry traditional Chinese medicine respectively at pulverizer grinding and sieving (sieve diameter 1mm), is collected the powder of diameter less than 1mm; Diameter is pulverized 1 time again greater than the raw material of 1mm also sieve equally, be used for soaking or extracting;
3), extract: the Chinese medicine mixture of above-mentioned pulverizing pack into sealable glass or rustless steel container, add 70-80% (v/v) alcoholic solution according to powder with the ratio (being that every liter of alcoholic solution adding mixes Chinese medicinal powder for 0.1 kilogram) of alcoholic solution 1/10 kg/liter, sealing was soaked 7 days.Filter with cloth, collect filtrate as preparation;
4), compliance test result: with cotton swab the said extracted liquid formulation directly is coated in the affected part, is coated with every day 2 times, continuous 6 days.
Therapeutic effect: trier 11 people (male 7 people, women 4 people, age 16-23 year) 53 places, coprocessing affected part, 2 courses of treatment (6 days), back 36 place affected part swelling obviously reduced wherein 27 places symptom complete obiteration, patient's pain, gargalesthesia obviously reduce, treatment effective percentage 67.9%.
No. 3, embodiment 3, comedo preparation, Chinese medicinal components proportioning and operating procedure are as follows:
1), Chinese medicinal components and proportioning (weight portion) are: Flos Chrysanthemi Indici 20, Radix Et Rhizoma Rhei 20, Rhizoma Coptidis 20, Cortex Phellodendri 20, Radix Scutellariae 20, Radix Salviae Miltiorrhizae 30, Flos Lonicerae 35, Herba Violae 35, Borneolum Syntheticum 4;
2), raw material pulverizing: above-mentioned dry traditional Chinese medicine respectively at pulverizer grinding and sieving (sieve diameter 1mm), is collected the powder of diameter less than 1mm; Diameter is pulverized 1 time again greater than the raw material of 1mm also sieve equally, be used for soaking or extracting;
3), extract: the important mixing of above-mentioned pulverizing pack into sealable glass or rustless steel container, add 80-90% (v/v) alcoholic solution according to powder with the ratio (being that every liter of alcoholic solution adding mixes Chinese medicinal powder for 2 kilograms) of alcoholic solution 2/1 kg/liter, sealing was soaked 3 days.Filter with cloth, collect filtrate as preparation;
4), compliance test result: with cotton swab the said extracted liquid formulation directly is coated in the affected part, is coated with every day 2 times, for three days on end.
Therapeutic effect: trier 8 people (man, each 4 people of woman, age 17-22 year) 36 places, coprocessing affected part, the affected part swelling of 34 place obviously reduces after 1 course of treatment, wherein 29 places symptom complete obiteration, patient's pain, gargalesthesia obviously reduce, treatment effective percentage 94%.
No. 4, embodiment 4, comedo preparation, Chinese medicinal components and proportioning and operating procedure are as follows:
1), Chinese medicinal components and proportioning (weight) are: Flos Chrysanthemi Indici 10, Radix Et Rhizoma Rhei 10, Rhizoma Coptidis 10, Cortex Phellodendri 10, Radix Scutellariae 10, Radix Salviae Miltiorrhizae 20, Flos Lonicerae 25, Herba Violae 25, Borneolum Syntheticum 2;
2), raw material pulverizing: above-mentioned dry traditional Chinese medicine respectively at pulverizer grinding and sieving (sieve diameter 1mm), is collected the powder of diameter less than 1mm; Diameter is pulverized 1 time again greater than the raw material of 1mm also sieve equally, be used for soaking or extracting;
3), extract: the important mixing of above-mentioned pulverizing pack into sealable glass or rustless steel container, add 50-60% (v/v) alcoholic solution according to powder with the ratio (being that every liter of alcoholic solution adding mixes Chinese medicinal powder for 0.1 kilogram) of alcoholic solution 1/10 kg/liter, sealing was soaked 15 days.Filter with cloth, collect filtrate as preparation;
4), compliance test result: with cotton swab the said extracted liquid formulation directly is coated in the affected part, is coated with every day 2 times, continuous 6 days.
Therapeutic effect: trier 11 people (male 7 people, women 4 people, age 16-23 year) 53 places, coprocessing affected part, 2 courses of treatment (6 days), back 36 place affected part swelling obviously reduced, wherein 27 places symptom complete obiteration, patient's pain, gargalesthesia obviously reduce, treatment effective percentage 68%.
At last, it is also to be noted that what more than enumerate only is 4 specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be arranged.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.
Claims (2)
1, comedo preparation is characterized in that: by weight, described comedo preparation is Flos Chrysanthemi Indici 10-20, Radix Et Rhizoma Rhei 10-20, Rhizoma Coptidis 10-20, Cortex Phellodendri 10-20, Radix Scutellariae 10-20, Radix Salviae Miltiorrhizae 20-30, Flos Lonicerae 25-35, Herba Violae 25-35, the ethanol extract of the whole components of Borneolum Syntheticum 2-4.
2, by the preparation method of the described comedo preparation of claim 1, it is characterized in that may further comprise the steps:
1) by weight, with exsiccant Flos Chrysanthemi Indici 10-20, Radix Et Rhizoma Rhei 10-20, Rhizoma Coptidis 10-20, Cortex Phellodendri 10-20, Radix Scutellariae 10-20, Radix Salviae Miltiorrhizae 20-30, Flos Lonicerae 25-35, Herba Violae 25-35, Borneolum Syntheticum 2-4 pulverizes the back respectively at pulverizer and sieves with sieve diameter 1mm, and greater than the raw material of 1mm crushing screening again, the collection diameter is less than the powder of 1mm with diameter;
2) pack into after the powder mixes of diameter with above-mentioned whole components sealable glass or rustless steel container less than 1mm, ratio adding concentration according to every liter of alcoholic solution 0.1-2 kilogram mixed-powder is the 50-90% alcoholic solution, sealing was soaked after 3-15 days, with cloth or filter paper filtering, obtain filtrate and be the comedo preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100531877A CN100457153C (en) | 2006-08-29 | 2006-08-29 | Medicine prepn. for treating acne, and its prepn. method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100531877A CN100457153C (en) | 2006-08-29 | 2006-08-29 | Medicine prepn. for treating acne, and its prepn. method |
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| Publication Number | Publication Date |
|---|---|
| CN1911331A CN1911331A (en) | 2007-02-14 |
| CN100457153C true CN100457153C (en) | 2009-02-04 |
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| CNB2006100531877A Expired - Fee Related CN100457153C (en) | 2006-08-29 | 2006-08-29 | Medicine prepn. for treating acne, and its prepn. method |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494926B (en) * | 2013-10-12 | 2015-08-26 | 肖晓芬 | A kind of medicine for external use for the treatment of rosacea, acne |
| CN104721412A (en) * | 2013-12-24 | 2015-06-24 | 康普药业股份有限公司 | Traditional Chinese medicine preparation for treating acnes and preparation method of traditional Chinese medicine preparation |
| CN104474257A (en) * | 2014-12-20 | 2015-04-01 | 钱家美 | Preparation for treating acnes |
| CN105511507A (en) * | 2015-12-11 | 2016-04-20 | 苏州泽达兴邦医药科技有限公司 | Liquid level stability control method in traditional Chinese medicine percolation process |
| CN106420452A (en) * | 2016-09-28 | 2017-02-22 | 郭豪 | Acne treatment cell repairing liquid |
| CN107468798A (en) * | 2017-09-05 | 2017-12-15 | 杨德芬 | A kind of composition for treating acne and its preparation method and application |
| CN107854371A (en) * | 2017-12-26 | 2018-03-30 | 珍尔姿（广州）化妆品有限公司 | A kind of composition with acne-removing |
| CN109999152A (en) * | 2019-04-17 | 2019-07-12 | 沈阳国和医疗科技有限公司 | A kind of pharmaceutical composition preparation method of anti-acne |
| CN111450223A (en) * | 2020-05-13 | 2020-07-28 | 云南省中医医院(云南中医药大学第一附属医院) | Acne cream |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386536A (en) * | 2002-05-16 | 2002-12-25 | 高学山 | Medicine for treating dermatopathy |
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2006
- 2006-08-29 CN CNB2006100531877A patent/CN100457153C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386536A (en) * | 2002-05-16 | 2002-12-25 | 高学山 | Medicine for treating dermatopathy |
Non-Patent Citations (2)
| Title |
|---|
| 痤疮的中医药治疗进展. 路涛.中医药信息，第2期. 1999 |
| 痤疮的中医药治疗进展. 路涛.中医药信息，第2期. 1999 * |
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| CN1911331A (en) | 2007-02-14 |
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