CN103340808A - Preparation technology for pseudo-ginseng medicament night cream - Google Patents
Preparation technology for pseudo-ginseng medicament night cream Download PDFInfo
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- CN103340808A CN103340808A CN2013103230439A CN201310323043A CN103340808A CN 103340808 A CN103340808 A CN 103340808A CN 2013103230439 A CN2013103230439 A CN 2013103230439A CN 201310323043 A CN201310323043 A CN 201310323043A CN 103340808 A CN103340808 A CN 103340808A
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Abstract
The invention relates to a preparation technology for a night cream, particularly relates to a preparation technology for a pseudo-ginseng medicament night cream, and belongs to the technical field of cosmetics. The preparation technology comprises the following steps of: on the basis of taking salvia, almond, angelica sinensis and precise herb pseudo-ginseng as main raw material, extracting components such as salvia extract, bitter apricot seed saponin, angelica sinensis extract and notoginsenoside, preparing reasonably and sterilizing; emulsifying at 85 DEG C, mixing and standing for 30 minutes; then stirring uniformly, cooling at room temperature, detecting the pH value of the microorganism of a semifinished product, and regulating the pH value to be 6.8; finally, filling, packaging, testing and putting in storage. The preparing pseudo-ginseng medicament night cream realizes the functions of resisting skin aging and improving skin whitening ability, can firm the skin, and promotes the absorption of nutrient substance, thus endowing people with pink-white and tender and beautiful skin; especially the added scutellaria baicalensis extract endows the pseudo-ginseng medicament night cream with an antibacterial effect, so that users of the pseudo-ginseng medicament night cream are further increased, and the applicability of the pseudo-ginseng medicament night cream is improved.
Description
Technical field
The present invention relates to a kind of preparation technology of late frost, particularly a kind of preparation technology of Radix Notoginseng medicine late frost belongs to the cosmetics technical field.
Background technology
Raising along with people's living standard, people's life stress is increasing, add allegro life, erratic diet has seriously corroded people's health, yet, in actual life, people are in the adaptation to work, and are also more and more higher for the pursuit of beauty, therefore, all kinds of cosmetics have become people, especially women's necessary article.
On daytime, skin carries out metabolism in rugged environment, is standing sunlight, dirty air, pollutant to its erosion.Evening is then different, discover according to Dermatology expert and dermal pathology scholars long-term observation, at 11 in evening to 5:00 AM is the Skin Cell growth and repairs the most vigorous the time that at this time fissional velocity ratio is fast about 8 times at ordinary times, thereby high especially to the absorbance of skin protection, nourishing food, simultaneously, skin night than the daytime in easier loss moisture, before the sleep, smear the last layer emulsion on the face, can prevent water loss, and increase the soft and smooth elasticity of skin such as silkiness.
Therefore, late frost is accounting for absolute consequence in cosmetics, and the active component of late frost is higher, and quality is also more moist, and have preserve moisture, maintenance, whiten, defying age, compact, nutrition moistens six large effects.
Yet along with the expansion day by day that late frost uses, its drawback also reveals gradually, and existing late frost mainly contains shortcoming:
1, removes a little less than the ability of free radical;
2, it is few to contain the composition of complexation ferrous ion, can not effectively reduce the caused free radical reaction of formation of ultraviolet radiation skin;
3, can not generate melanic oxidative pathway by restraint of tyrosinase activity or blocking-up tyrosine, reach skin whitening effects thereby reduce melanic generation;
4, chemical constituent too high being unfavorable for absorbs, and side effect is many;
5, after late frost is coated, form a skim at face, may breed bacteria, be unfavorable for facial the breathing, be unfavorable for the discharge of harmful substance in the body.
In view of the critical role of late frost in daily nursing, the technology that necessary employing is new overcomes above-mentioned shortcoming, to adapt to people's needs.
Summary of the invention
At the problems referred to above, the present invention proposes a kind of preparation technology of Radix Notoginseng medicine late frost; With Radix Salviae Miltiorrhizae, Semen Armeniacae Amarum, Radix Angelicae Sinensis and valuable ingredient of Chinese medicine Radix Notoginseng primary raw material, extract Radix Salviae Miltiorrhizae extract, Semen Armeniacae Amarum saponin, Radix Angelicae Sinensis extract and arasaponin composition, carry out rational proportion, be fitted to each other, Radix Notoginseng medicine late frost is made in synergy, realizes resisting age of skin, improves the skin ability of whitening, can tighten up skin, promote nutrient substance absorption, make skin white touched with red, delicate and charming pleasant; Especially the interpolation of Radix Scutellariae extract has more increased the antibacterial effect of Radix Notoginseng medicine late frost, has further enlarged the use crowd of Radix Notoginseng medicine late frost, has improved the suitability of Radix Notoginseng medicine late frost.
For realizing goal of the invention, the technical solution used in the present invention: a kind of preparation technology of Radix Notoginseng medicine late frost carries out according to following step:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt ultrasonic extraction, ethanol refluxing process to extract, the cellulose enzyme solution is extracted, the pectinase enzymatic hydrolysis method is extracted, the enzymolyzing alpha-amylase method is extracted, the complex enzyme zymohydrolysis method is extracted and half bionical-enzymolyzing alpha-amylase extraction method;
Utilize Radix Salviae Miltiorrhizae to extract Radix Salviae Miltiorrhizae extract, at first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter merging filtrate, decompression recycling ethanol and under 60 ° of C temperature, being condensed into relative density is the 1.30-1.35 thick paste, colourless to washing liquid with hot water wash, carries out drying under 80 ° of C temperature, be ground into fine powder, it is standby to make Radix Salviae Miltiorrhizae extract;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, with Radix Angelicae Sinensis 100 g fragmentations, under 80 ℃ temperature, dry, pulverize then, cross 40 mesh sieve; Divide with distilled water and carry out lixiviate 3 times, 3 amount of water are respectively heavy 10,6,4 times of Radix Angelicae Sinensis; Each extraction temperature is 100 ℃, times 30 min; Merge 3 times lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, carry out filtrate processing then, adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min again, carry out filtrate processing again, obtain the Radix Angelicae Sinensis extract concentrated solution finally by crossing rotary evaporation;
Utilize Semen Armeniacae Amarum to extract the Semen Armeniacae Amarum saponin, at first, Semen Armeniacae Amarum is carried out drying, making described amygdalate water activity is 0.10-0.70; Then, be crushed to 10 orders-120 order; Keeping extracting Semen Armeniacae Amarum oil under the constant condition of water activity; The ethanol water that with mass percentage concentration is 50%-95% carries out separation and Extraction to the Semen Armeniacae Amarum dregs of rice, obtains Semen Armeniacae Amarum saponin and Semen Armeniacae Amarum albumen;
Second goes on foot, prepares burden according to prescription;
Comprise arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water according to Radix Notoginseng medicine late frost; The mass percent of each component is: arasaponin 10-35 part, Radix Salviae Miltiorrhizae extract 5-25 part, Radix Angelicae Sinensis extract 5-25 part, glycerol 1-10 part, peregal 1-5 part, lanoline 0.5-5 part, polyoxyethylene sorbitol acid anhydride olein 0.5-4 part, Semen Armeniacae Amarum saponin 0.1-0.5 part, mud pool tortoise beetle ester 0.1-0.4 part, surplus is that water is prepared burden;
The 3rd step, sterilization treatment;
The 4th the step, under 85 ℃ of temperature, carry out emulsifying;
30min is left standstill in the 5th step, mixing;
The 6th goes on foot, stirs, cooling at room temperature;
The 7th step, inspection of semifinished product microorganism ph value; With ph value modulation 6.8;
The 8th step, fill, packing, check, warehouse-in.
Utilize Radix Notoginseng to extract in the first step and adopt half bionical enzyme process in the arasaponin, extraction conditions is 70 ℃ of temperature, and times 2.5 h, solid-liquid ratio are 1:10.
95% ethanol extraction that utilizes Semen Armeniacae Amarum to extract to adopt 6 times of amounts in the Semen Armeniacae Amarum saponin in the first step 2 times, each 1h, the gained crude product is used the dehydrated alcohol of 1: 30 solid-to-liquid ratio again, recrystallization three times, obtain content and be 92.47% the pure product of Semen Armeniacae Amarum saponin, the Semen Armeniacae Amarum saponin rate of transform is 45.92%.
In second step, in Radix Notoginseng medicine late frost, add Radix Scutellariae extract, mass percent according to each component is: 24 parts of arasaponins, 10 parts of Radix Salviae Miltiorrhizae extracts, 10 parts of Radix Scutellariae extracts, 10 parts of Radix Angelicae Sinensis extracts, 7 parts of glycerol, 5 parts of peregals, 3 parts of lanolines, 3 parts of polyoxyethylene sorbitol acid anhydride oleins, 2 parts of Semen Armeniacae Amarum saponin, 0.2 part of mud pool tortoise beetle ester, surplus is that water is prepared burden.
Utilize Radix Scutellariae to extract baicalin and can adopt traditional water to put forward acid precipitation method and alcohol extraction acid precipitation method, adopt ultrasonic extraction as the best approach.
Beneficial effect of the present invention: the present invention is with Radix Salviae Miltiorrhizae, Semen Armeniacae Amarum, Radix Angelicae Sinensis and valuable ingredient of Chinese medicine Radix Notoginseng primary raw material, extract Radix Salviae Miltiorrhizae extract, Semen Armeniacae Amarum saponin, Radix Angelicae Sinensis extract and arasaponin composition, carry out rational proportion, be fitted to each other, Radix Notoginseng medicine late frost is made in synergy, realizes resisting age of skin, improves the skin ability of whitening, can tighten up skin, promote nutrient substance absorption, make skin white touched with red, delicate and charming pleasant; Especially the interpolation of Radix Scutellariae extract has more increased the antibacterial effect of Radix Notoginseng medicine late frost, has further enlarged the use crowd of Radix Notoginseng medicine late frost, has improved the suitability of Radix Notoginseng medicine late frost.
Description of drawings
Fig. 1 is preparation technology's flow chart of the present invention.
The specific embodiment
The invention will be further described with concrete enforcement below in conjunction with accompanying drawing, understands to make things convenient for the technical staff.
Embodiment 1:
As shown in Figure 1, a kind of preparation technology of Radix Notoginseng medicine late frost, carry out according to following step:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt ultrasonic extraction, ethanol refluxing process to extract, the cellulose enzyme solution is extracted, the pectinase enzymatic hydrolysis method is extracted, the enzymolyzing alpha-amylase method is extracted, the complex enzyme zymohydrolysis method is extracted and half bionical-enzymolyzing alpha-amylase extraction method;
Utilize Radix Salviae Miltiorrhizae to extract Radix Salviae Miltiorrhizae extract, at first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter merging filtrate, decompression recycling ethanol and under 60 ° of C temperature, being condensed into relative density is the 1.30-1.35 thick paste, colourless to washing liquid with hot water wash, carries out drying under 80 ° of C temperature, be ground into fine powder, it is standby to make Radix Salviae Miltiorrhizae extract;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, with Radix Angelicae Sinensis 100 g fragmentations, under 80 ℃ temperature, dry, pulverize then, cross 40 mesh sieve; Divide with distilled water and carry out lixiviate 3 times, 3 amount of water are respectively heavy 10,6,4 times of Radix Angelicae Sinensis; Each extraction temperature is 100 ℃, times 30 min; Merge 3 times lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, carry out filtrate processing then, adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min again, carry out filtrate processing again, obtain the Radix Angelicae Sinensis extract concentrated solution finally by crossing rotary evaporation;
Utilize Semen Armeniacae Amarum to extract the Semen Armeniacae Amarum saponin, at first, Semen Armeniacae Amarum is carried out drying, making described amygdalate water activity is 0.10-0.70; Then, be crushed to 10 orders-120 order; Keeping extracting Semen Armeniacae Amarum oil under the constant condition of water activity; The ethanol water that with mass percentage concentration is 50%-95% carries out separation and Extraction to the Semen Armeniacae Amarum dregs of rice, obtains Semen Armeniacae Amarum saponin and Semen Armeniacae Amarum albumen;
Second goes on foot, prepares burden according to prescription;
Comprise arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water according to Radix Notoginseng medicine late frost; Wherein the mass percent of each component is: arasaponin 10-35 part, Radix Salviae Miltiorrhizae extract 5-25 part, Radix Angelicae Sinensis extract 5-25 part, glycerol 1-10 part, peregal 1-5 part, lanoline 0.5-5 part, polyoxyethylene sorbitol acid anhydride olein 0.5-4 part, Semen Armeniacae Amarum saponin 0.1-0.5 part, mud pool tortoise beetle ester 0.1-0.4 part, surplus is that water is prepared burden;
The 3rd step, sterilization treatment;
The 4th the step, under 85 ℃ of temperature, carry out emulsifying;
30min is left standstill in the 5th step, mixing;
The 6th goes on foot, stirs, cooling at room temperature;
The 7th step, inspection of semifinished product microorganism ph value; With ph value modulation 6.8;
The 8th step, fill, packing, check, warehouse-in.
Embodiment 2:
The preparation technology of Radix Notoginseng medicine late frost carries out according to following step:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt half bionical enzyme process, extraction conditions is 70 ℃ of temperature, and times 2.5 h, solid-liquid ratio are 1:10.
Utilize Radix Salviae Miltiorrhizae to extract Radix Salviae Miltiorrhizae extract, at first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter merging filtrate, decompression recycling ethanol and under 60 ° of C temperature, being condensed into relative density is the 1.30-1.35 thick paste, colourless to washing liquid with hot water wash, carries out drying under 80 ° of C temperature, be ground into fine powder, it is standby to make Radix Salviae Miltiorrhizae extract;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, with Radix Angelicae Sinensis 100 g fragmentations, under 80 ℃ temperature, dry, pulverize then, cross 40 mesh sieve; Divide with distilled water and carry out lixiviate 3 times, 3 amount of water are respectively heavy 10,6,4 times of Radix Angelicae Sinensis; Each extraction temperature is 100 ℃, times 30 min; Merge 3 times lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, carry out filtrate processing then, adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min again, carry out filtrate processing again, obtain the Radix Angelicae Sinensis extract concentrated solution finally by crossing rotary evaporation;
Utilize Semen Armeniacae Amarum to extract the Semen Armeniacae Amarum saponin, at first, Semen Armeniacae Amarum is carried out drying, making described amygdalate water activity is 0.10-0.70; Then, be crushed to 10 orders-120 order; Keeping extracting Semen Armeniacae Amarum oil under the constant condition of water activity; Adopt 95% ethanol extraction 2 times of 6 times of amounts, each 1h, the gained crude product is used the dehydrated alcohol of 1: 30 solid-to-liquid ratio again, and recrystallization three times obtains content and is 92.47% the pure product of Semen Armeniacae Amarum saponin, and the Semen Armeniacae Amarum saponin rate of transform is 45.92%.
Utilize Radix Scutellariae to extract baicalin and can adopt traditional water to put forward acid precipitation method and alcohol extraction acid precipitation method, adopt ultrasonic extraction as the best approach.
Second goes on foot, prepares burden according to prescription;
Comprise arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, Radix Scutellariae extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water according to Radix Notoginseng medicine late frost; Mass percent according to each component is: 24 parts of arasaponins, 10 parts of Radix Salviae Miltiorrhizae extracts, 10 parts of Radix Scutellariae extracts, 10 parts of Radix Angelicae Sinensis extracts, 7 parts of glycerol, 5 parts of peregals, 3 parts of lanolines, 3 parts of polyoxyethylene sorbitol acid anhydride oleins, 2 parts of Semen Armeniacae Amarum saponin, 0.2 part of mud pool tortoise beetle ester, surplus is that water is prepared burden.
The 3rd step, sterilization treatment;
The 4th the step, under 85 ℃ of temperature, carry out emulsifying;
30min is left standstill in the 5th step, mixing;
The 6th goes on foot, stirs, cooling at room temperature;
The 7th step, inspection of semifinished product microorganism ph value; With ph value modulation 6.8;
The 8th step, fill, packing, check, warehouse-in.
Embodiment 3
The preparation technology of Radix Notoginseng medicine late frost carries out according to following step:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt ultrasonic extraction, ethanol refluxing process to extract, the cellulose enzyme solution is extracted, the pectinase enzymatic hydrolysis method is extracted, the enzymolyzing alpha-amylase method is extracted, the complex enzyme zymohydrolysis method is extracted and half bionical-enzymolyzing alpha-amylase extraction method;
Utilize Radix Salviae Miltiorrhizae to extract Radix Salviae Miltiorrhizae extract, at first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter merging filtrate, decompression recycling ethanol and under 60 ° of C temperature, being condensed into relative density is the 1.30-1.35 thick paste, colourless to washing liquid with hot water wash, carries out drying under 80 ° of C temperature, be ground into fine powder, it is standby to make Radix Salviae Miltiorrhizae extract;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, with Radix Angelicae Sinensis 100 g fragmentations, under 80 ℃ temperature, dry, pulverize then, cross 40 mesh sieve; Divide with distilled water and carry out lixiviate 3 times, 3 amount of water are respectively heavy 10,6,4 times of Radix Angelicae Sinensis; Each extraction temperature is 100 ℃, times 30 min; Merge 3 times lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, carry out filtrate processing then, adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min again, carry out filtrate processing again, obtain the Radix Angelicae Sinensis extract concentrated solution finally by crossing rotary evaporation;
Utilize Semen Armeniacae Amarum to extract the Semen Armeniacae Amarum saponin, at first, Semen Armeniacae Amarum is carried out drying, making described amygdalate water activity is 0.10-0.70; Then, be crushed to 10 orders-120 order; Keeping extracting Semen Armeniacae Amarum oil under the constant condition of water activity; The ethanol water that with mass percentage concentration is 50%-95% carries out separation and Extraction to the Semen Armeniacae Amarum dregs of rice, obtains Semen Armeniacae Amarum saponin and Semen Armeniacae Amarum albumen;
Second goes on foot, prepares burden according to prescription;
Comprise arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water according to Radix Notoginseng medicine late frost; The mass percent of each component is: 24 parts of arasaponins, 15 parts of Radix Salviae Miltiorrhizae extracts, 15 parts of Radix Angelicae Sinensis extracts, 7 parts of glycerol, 5 parts of peregals, 3 parts of lanolines, 3 parts of polyoxyethylene sorbitol acid anhydride oleins, 2 parts of Semen Armeniacae Amarum saponin, 0.2 part of mud pool tortoise beetle ester, surplus is that water carries out proportioning;
The 3rd step, sterilization treatment;
The 4th the step, under 85 ℃ of temperature, carry out emulsifying;
30min is left standstill in the 5th step, mixing;
The 6th goes on foot, stirs, cooling at room temperature;
The 7th step, inspection of semifinished product microorganism ph value; With ph value modulation 6.8;
The 8th step, fill, packing, check, warehouse-in.
The present invention is with Radix Salviae Miltiorrhizae, Semen Armeniacae Amarum, Radix Angelicae Sinensis and valuable ingredient of Chinese medicine Radix Notoginseng primary raw material, extract Radix Salviae Miltiorrhizae extract, Semen Armeniacae Amarum saponin, Radix Angelicae Sinensis extract and arasaponin composition, carry out rational proportion, be fitted to each other, Radix Notoginseng medicine late frost is made in synergy, realizes resisting age of skin, improves the skin ability of whitening, can tighten up skin, promote nutrient substance absorption, make skin white touched with red, delicate and charming pleasant; Especially the interpolation of Radix Scutellariae extract has more increased the antibacterial effect of Radix Notoginseng medicine late frost, has further enlarged the use crowd of Radix Notoginseng medicine late frost, has improved the suitability of Radix Notoginseng medicine late frost.
The content that the present invention describes by embodiment, without departing from the present invention, can also carry out various conversion and be equal to replacement patent of the present invention, therefore, patent of the present invention is not limited to disclosed specific implementation process, and should comprise the whole embodiments that fall in the Patent right requirement scope of the present invention.
Claims (6)
1. the preparation technology of a Radix Notoginseng medicine late frost, it is characterized in that: Radix Notoginseng medicine late frost carries out according to following step:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt ultrasonic extraction, ethanol refluxing process to extract, the cellulose enzyme solution is extracted, the pectinase enzymatic hydrolysis method is extracted, the enzymolyzing alpha-amylase method is extracted, the complex enzyme zymohydrolysis method is extracted and half bionical-enzymolyzing alpha-amylase extraction method;
Utilize Radix Salviae Miltiorrhizae to extract Radix Salviae Miltiorrhizae extract, at first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter merging filtrate, decompression recycling ethanol and under 60 ° of C temperature, being condensed into relative density is the 1.30-1.35 thick paste, colourless to washing liquid with hot water wash, carries out drying under 80 ° of C temperature, be ground into fine powder, it is standby to make Radix Salviae Miltiorrhizae extract;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, with Radix Angelicae Sinensis 100 g fragmentations, under 80 ℃ temperature, dry, pulverize then, cross 40 mesh sieve; Divide with distilled water and carry out lixiviate 3 times, 3 amount of water are respectively heavy 10,6,4 times of Radix Angelicae Sinensis; Each extraction temperature is 100 ℃, times 30 min; Merge 3 times lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, carry out filtrate processing then, adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min again, carry out filtrate processing again, obtain the Radix Angelicae Sinensis extract concentrated solution finally by crossing rotary evaporation;
Utilize Semen Armeniacae Amarum to extract the Semen Armeniacae Amarum saponin, at first, Semen Armeniacae Amarum is carried out drying, making described amygdalate water activity is 0.10-0.70; Then, be crushed to 10 orders-120 order; Keeping extracting Semen Armeniacae Amarum oil under the constant condition of water activity; The ethanol water that with mass percentage concentration is 50%-95% carries out separation and Extraction to the Semen Armeniacae Amarum dregs of rice, obtains Semen Armeniacae Amarum saponin and Semen Armeniacae Amarum albumen;
Second goes on foot, prepares burden according to prescription;
Comprise arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water according to Radix Notoginseng medicine late frost; The mass percent of each component is: arasaponin 10-35 part, Radix Salviae Miltiorrhizae extract 5-25 part, Radix Angelicae Sinensis extract 5-25 part, glycerol 1-10 part, peregal 1-5 part, lanoline 0.5-5 part, polyoxyethylene sorbitol acid anhydride olein 0.5-4 part, Semen Armeniacae Amarum saponin 0.1-0.5 part, mud pool tortoise beetle ester 0.1-0.4 part, surplus is that water is prepared burden;
The 3rd step, sterilization treatment;
The 4th the step, under 85 ℃ of temperature, carry out emulsifying;
30min is left standstill in the 5th step, mixing;
The 6th goes on foot, stirs, cooling at room temperature;
The 7th step, inspection of semifinished product microorganism ph value; With ph value modulation 6.8;
The 8th step, fill, packing, check, warehouse-in.
2. the preparation technology of a kind of Radix Notoginseng medicine late frost according to claim 1 is characterized in that: utilize Radix Notoginseng to extract in the first step and adopt half bionical enzyme process in the arasaponin, extraction conditions is 70 ℃ of temperature, and times 2.5 h, solid-liquid ratio are 1:10.
3. the preparation technology of a kind of Radix Notoginseng medicine late frost according to claim 1, it is characterized in that: 95% ethanol extraction that utilizes Semen Armeniacae Amarum to extract to adopt 6 times of amounts in the Semen Armeniacae Amarum saponin in the first step 2 times, each 1h, the gained crude product is used the dehydrated alcohol of 1: 30 solid-to-liquid ratio again, recrystallization three times obtains content and is 92.47% the pure product of Semen Armeniacae Amarum saponin.
4. the preparation technology of a kind of Radix Notoginseng medicine late frost according to claim 1 is characterized in that: comprise arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water according to Radix Notoginseng medicine late frost in second step; The mass percent of each component is: 24 parts of arasaponins, 15 parts of Radix Salviae Miltiorrhizae extracts, 15 parts of Radix Angelicae Sinensis extracts, 7 parts of glycerol, 5 parts of peregals, 3 parts of lanolines, 3 parts of polyoxyethylene sorbitol acid anhydride oleins, 2 parts of Semen Armeniacae Amarum saponin, 0.2 part of mud pool tortoise beetle ester, surplus is that water carries out proportioning.
5. the preparation technology of a kind of Radix Notoginseng medicine late frost according to claim 1, it is characterized in that: in second step, in Radix Notoginseng medicine late frost, add Radix Scutellariae extract, mass percent according to each component is: 24 parts of arasaponins, 10 parts of Radix Salviae Miltiorrhizae extracts, 10 parts of Radix Scutellariae extracts, 10 parts of Radix Angelicae Sinensis extracts, 7 parts of glycerol, 5 parts of peregals, 3 parts of lanolines, 3 parts of polyoxyethylene sorbitol acid anhydride oleins, 2 parts of Semen Armeniacae Amarum saponin, 0.2 part of mud pool tortoise beetle ester, surplus is that water is prepared burden.
6. the preparation technology of a kind of Radix Notoginseng medicine late frost according to claim 5 is characterized in that: utilize Radix Scutellariae to extract baicalin and can adopt traditional water to put forward acid precipitation method and alcohol extraction acid precipitation method, adopt ultrasonic extraction as the best approach.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893774A (en) * | 2014-04-10 | 2014-07-02 | 杨冰 | Application of beta-amylase in extraction of panax notoginseng saponins |
| CN103933092A (en) * | 2014-04-10 | 2014-07-23 | 文山学院文山三七研究院 | Method for extracting panax notoginseng saponins from fresh panax notoginseng by complex enzyme |
| CN104523471A (en) * | 2014-12-04 | 2015-04-22 | 云南人羞花化妆品有限公司 | Morning pseudo-ginseng cream and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103893774A (en) * | 2014-04-10 | 2014-07-02 | 杨冰 | Application of beta-amylase in extraction of panax notoginseng saponins |
| CN103933092A (en) * | 2014-04-10 | 2014-07-23 | 文山学院文山三七研究院 | Method for extracting panax notoginseng saponins from fresh panax notoginseng by complex enzyme |
| CN103893774B (en) * | 2014-04-10 | 2016-01-06 | 云南省腾冲县东方红制药有限责任公司 | A kind of beta amylase is extracting the application in Radix Notoginseng total arasaponins |
| CN104523471A (en) * | 2014-12-04 | 2015-04-22 | 云南人羞花化妆品有限公司 | Morning pseudo-ginseng cream and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103340808B (en) | 2015-08-05 |
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