Background technology
Along with the raising of people's living standard, the life stress of people is increasing, add allegro life, the erratic diet Eroded health of people, but, in actual life, people are in the adaptation to work, and the pursuit for beauty is also more and more higher, therefore, all kinds of cosmetics have become people, especially the necessary article of women.
On daytime, skin carries out metabolism in rugged environment, suffer from sunlight, dirty air, pollutant to its erosion.Evening is then different, find according to Dermatology expert and the research of dermal pathology scholars long-term observation, at 11 in evening to 5:00 AM be dermal cell growth and repair the most vigorous time, at this time fissional velocity ratio fast about 8 times at ordinary times, thus high especially to the absorbance of skin protection, nourishing food, simultaneously, skin than the moisture that runs off easier in the daytime, before sleep, is smearing last layer emulsion at night on the face, can water loss be prevented, and increase the soft and smooth elasticity of skin as silkiness.
Therefore, late frost accounts for definitely consequence in cosmetics, and the active component of late frost is higher, and quality is also more moist, and there is moisturizing, maintenance, whitening, defying age, compact, nutrition moistens six large effects.
But, the expanding day used along with late frost, its drawback also reveals gradually, and existing late frost mainly contains shortcoming:
1, the ability of scavenging free radicals is weak;
2, the composition containing complexation ferrous ion is few, effectively can not reduce the free radical reaction of formation caused by ultraviolet radiation skin;
3, active by restraint of tyrosinase or blocking-up tyrosine generates melanic oxidative pathway, thus reduces the effect that melanic generation reaches skin whitening;
4, chemical composition too high being unfavorable for absorbs, and side effect is many;
5, after late frost is coated, a skim is formed at face, may breed bacteria, be unfavorable for that face is breathed, be unfavorable for the discharge of harmful substance in body.
In view of the critical role of late frost in daily nursing, the technology that necessary employing is new, overcomes above-mentioned shortcoming, to adapt to the needs of people.
Summary of the invention
For the problems referred to above, the present invention proposes a kind of preparation technology of pseudo-ginseng medicament night cream; With Radix Salviae Miltiorrhizae, Semen Armeniacae Amarum, Radix Angelicae Sinensis and valuable ingredient of Chinese medicine Radix Notoginseng primary raw material, extract Radix Salviae Miltiorrhizae extract, Semen Armeniacae Amarum saponin, Radix Angelicae Sinensis extract and saponin, carry out rational proportion, be fitted to each other, synergy, makes pseudo-ginseng medicament night cream, realizes resisting age of skin, improves skin whitening capability, can skin be tightened up, promote the absorption of nutrient substance, make skin white touched with red, delicate and charming pleasant; Especially the interpolation of Radix Scutellariae extract further increases the antibacterial effect of pseudo-ginseng medicament night cream, expands the use crowd of pseudo-ginseng medicament night cream further, improves the suitability of pseudo-ginseng medicament night cream.
For realizing goal of the invention, the technical solution used in the present invention: a kind of preparation technology of pseudo-ginseng medicament night cream carries out according to step below:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt that ultrasonic extraction, ethanol refluxing process extract, cellulose enzyme solution is extracted, pectinase enzymatic hydrolysis method is extracted, enzymolyzing alpha-amylase method is extracted, complex enzyme zymohydrolysis method is extracted and half bionical-enzymolyzing alpha-amylase extraction method;
Radix Salviae Miltiorrhizae is utilized to extract Radix Salviae Miltiorrhizae extract, first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter, merging filtrate, decompression recycling ethanol at 60 ° of C temperature, being condensed into relative density is 1.30-1.35 thick paste, colourless to washing liquid by hot water wash, at 80 ° of C temperature, carry out drying, be ground into fine powder, make Radix Salviae Miltiorrhizae extract for subsequent use;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, Radix Angelicae Sinensis 100 g is broken, dry at the temperature of 80 DEG C, then pulverize, cross 40 mesh sieve; Divide with distilled water again and carry out lixiviate 3 times, 3 amount of water be respectively Radix Angelicae Sinensis heavy 10,6,4 times; Each extraction temperature is 100 DEG C, time 30 min; Merge 3 lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, then carry out filtrate process, again adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min, again carry out filtrate process, eventually pass rotary evaporation and obtain Radix Angelicae Sinensis extract concentrated solution;
Utilize Semen Armeniacae Amarum to extract Semen Armeniacae Amarum saponin, first, Semen Armeniacae Amarum is carried out drying, make described amygdalate water activity be 0.10-0.70; Then, 10 order-120 orders are crushed to; Under the condition keeping water activity constant, extract Semen Armeniacae Amarum oil; Be that the ethanol water of 50%-95% carries out separation and Extraction to the Semen Armeniacae Amarum dregs of rice by mass percentage concentration, obtain Semen Armeniacae Amarum saponin and Almond Proteins;
Second step, to prepare burden according to formula;
Arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water is comprised according to pseudo-ginseng medicament night cream; The mass percent of each component is: arasaponin 10-35 part, Radix Salviae Miltiorrhizae extract 5-25 part, Radix Angelicae Sinensis extract 5-25 part, glycerol 1-10 part, peregal 1-5 part, lanoline 0.5-5 part, polyoxyethylene sorbitol acid anhydride olein 0.5-4 part, Semen Armeniacae Amarum saponin 0.1-0.5 part, mud pool tortoise beetle ester 0.1-0.4 part, surplus is that water is prepared burden;
3rd step, sterilization treatment;
4th step, at 85 DEG C of temperature, carry out emulsifying;
5th step, mixing leave standstill 30min;
6th step, to stir, at room temperature cool;
7th step, inspection of semifinished product microorganism ph value; By ph value modulation 6.8;
8th step, fill, packaging, inspection, warehouse-in.
Utilize Radix Notoginseng to extract in arasaponin in the first step and adopt half biomimetic enzyme method, extraction conditions is temperature 70 C, time 2.5 h, and solid-liquid ratio is 1:10.
95% ethanol extraction 2 times of 6 times amount is utilized Semen Armeniacae Amarum to extract to adopt in Semen Armeniacae Amarum saponin in the first step, each 1h, gained crude product uses the dehydrated alcohol of 1: 30 solid-to-liquid ratio again, recrystallization three times, obtain the Semen Armeniacae Amarum saponin sterling that content is 92.47%, the Semen Armeniacae Amarum saponin rate of transform is 45.92%.
In pseudo-ginseng medicament night cream, Radix Scutellariae extract is added in second step, according to the mass percent of each component be: arasaponin 24 parts, Radix Salviae Miltiorrhizae extract 10 parts, Radix Scutellariae extract 10 parts, Radix Angelicae Sinensis extract 10 parts, glycerol 7 parts, peregal 5 parts, lanoline 3 parts, polyoxyethylene sorbitol acid anhydride olein 3 parts, Semen Armeniacae Amarum saponin 2 parts, mud pool tortoise beetle ester 0.2 part, surplus is that water is prepared burden.
Utilize Radix Scutellariae to extract baicalin and can adopt traditional heavy method of water extraction acid and alcohol extraction and acid precipitation method, adopt ultrasonic extraction as the best approach.
Beneficial effect of the present invention: the present invention is with Radix Salviae Miltiorrhizae, Semen Armeniacae Amarum, Radix Angelicae Sinensis and valuable ingredient of Chinese medicine Radix Notoginseng primary raw material, extract Radix Salviae Miltiorrhizae extract, Semen Armeniacae Amarum saponin, Radix Angelicae Sinensis extract and saponin, carry out rational proportion, be fitted to each other, synergy, makes pseudo-ginseng medicament night cream, realizes resisting age of skin, improves skin whitening capability, can skin be tightened up, promote the absorption of nutrient substance, make skin white touched with red, delicate and charming pleasant; Especially the interpolation of Radix Scutellariae extract further increases the antibacterial effect of pseudo-ginseng medicament night cream, expands the use crowd of pseudo-ginseng medicament night cream further, improves the suitability of pseudo-ginseng medicament night cream.
Detailed description of the invention
Below in conjunction with accompanying drawing, the invention will be further described, to facilitate the technical staff to understand with concrete enforcement.
Embodiment 1:
As shown in Figure 1, a kind of preparation technology of pseudo-ginseng medicament night cream, carries out according to step below:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt that ultrasonic extraction, ethanol refluxing process extract, cellulose enzyme solution is extracted, pectinase enzymatic hydrolysis method is extracted, enzymolyzing alpha-amylase method is extracted, complex enzyme zymohydrolysis method is extracted and half bionical-enzymolyzing alpha-amylase extraction method;
Radix Salviae Miltiorrhizae is utilized to extract Radix Salviae Miltiorrhizae extract, first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter, merging filtrate, decompression recycling ethanol at 60 ° of C temperature, being condensed into relative density is 1.30-1.35 thick paste, colourless to washing liquid by hot water wash, at 80 ° of C temperature, carry out drying, be ground into fine powder, make Radix Salviae Miltiorrhizae extract for subsequent use;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, Radix Angelicae Sinensis 100 g is broken, dry at the temperature of 80 DEG C, then pulverize, cross 40 mesh sieve; Divide with distilled water again and carry out lixiviate 3 times, 3 amount of water be respectively Radix Angelicae Sinensis heavy 10,6,4 times; Each extraction temperature is 100 DEG C, time 30 min; Merge 3 lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, then carry out filtrate process, again adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min, again carry out filtrate process, eventually pass rotary evaporation and obtain Radix Angelicae Sinensis extract concentrated solution;
Utilize Semen Armeniacae Amarum to extract Semen Armeniacae Amarum saponin, first, Semen Armeniacae Amarum is carried out drying, make described amygdalate water activity be 0.10-0.70; Then, 10 order-120 orders are crushed to; Under the condition keeping water activity constant, extract Semen Armeniacae Amarum oil; Be that the ethanol water of 50%-95% carries out separation and Extraction to the Semen Armeniacae Amarum dregs of rice by mass percentage concentration, obtain Semen Armeniacae Amarum saponin and Almond Proteins;
Second step, to prepare burden according to formula;
Arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water is comprised according to pseudo-ginseng medicament night cream; Wherein the mass percent of each component is: arasaponin 10-35 part, Radix Salviae Miltiorrhizae extract 5-25 part, Radix Angelicae Sinensis extract 5-25 part, glycerol 1-10 part, peregal 1-5 part, lanoline 0.5-5 part, polyoxyethylene sorbitol acid anhydride olein 0.5-4 part, Semen Armeniacae Amarum saponin 0.1-0.5 part, mud pool tortoise beetle ester 0.1-0.4 part, surplus is that water is prepared burden;
3rd step, sterilization treatment;
4th step, at 85 DEG C of temperature, carry out emulsifying;
5th step, mixing leave standstill 30min;
6th step, to stir, at room temperature cool;
7th step, inspection of semifinished product microorganism ph value; By ph value modulation 6.8;
8th step, fill, packaging, inspection, warehouse-in.
Embodiment 2:
The preparation technology of pseudo-ginseng medicament night cream carries out according to step below:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt half biomimetic enzyme method, extraction conditions is temperature 70 C, time 2.5 h, and solid-liquid ratio is 1:10.
Radix Salviae Miltiorrhizae is utilized to extract Radix Salviae Miltiorrhizae extract, first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter, merging filtrate, decompression recycling ethanol at 60 ° of C temperature, being condensed into relative density is 1.30-1.35 thick paste, colourless to washing liquid by hot water wash, at 80 ° of C temperature, carry out drying, be ground into fine powder, make Radix Salviae Miltiorrhizae extract for subsequent use;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, Radix Angelicae Sinensis 100 g is broken, dry at the temperature of 80 DEG C, then pulverize, cross 40 mesh sieve; Divide with distilled water again and carry out lixiviate 3 times, 3 amount of water be respectively Radix Angelicae Sinensis heavy 10,6,4 times; Each extraction temperature is 100 DEG C, time 30 min; Merge 3 lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, then carry out filtrate process, again adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min, again carry out filtrate process, eventually pass rotary evaporation and obtain Radix Angelicae Sinensis extract concentrated solution;
Utilize Semen Armeniacae Amarum to extract Semen Armeniacae Amarum saponin, first, Semen Armeniacae Amarum is carried out drying, make described amygdalate water activity be 0.10-0.70; Then, 10 order-120 orders are crushed to; Under the condition keeping water activity constant, extract Semen Armeniacae Amarum oil; Adopt 95% ethanol extraction 2 times of 6 times amount, each 1h, gained crude product uses the dehydrated alcohol of 1: 30 solid-to-liquid ratio again, recrystallization three times, and obtain the Semen Armeniacae Amarum saponin sterling that content is 92.47%, the Semen Armeniacae Amarum saponin rate of transform is 45.92%.
Utilize Radix Scutellariae to extract baicalin and can adopt traditional heavy method of water extraction acid and alcohol extraction and acid precipitation method, adopt ultrasonic extraction as the best approach.
Second step, to prepare burden according to formula;
Arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, Radix Scutellariae extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water is comprised according to pseudo-ginseng medicament night cream; According to the mass percent of each component be: arasaponin 24 parts, Radix Salviae Miltiorrhizae extract 10 parts, Radix Scutellariae extract 10 parts, Radix Angelicae Sinensis extract 10 parts, glycerol 7 parts, peregal 5 parts, lanoline 3 parts, polyoxyethylene sorbitol acid anhydride olein 3 parts, Semen Armeniacae Amarum saponin 2 parts, mud pool tortoise beetle ester 0.2 part, surplus is that water is prepared burden.
3rd step, sterilization treatment;
4th step, at 85 DEG C of temperature, carry out emulsifying;
5th step, mixing leave standstill 30min;
6th step, to stir, at room temperature cool;
7th step, inspection of semifinished product microorganism ph value; By ph value modulation 6.8;
8th step, fill, packaging, inspection, warehouse-in.
Embodiment 3
The preparation technology of pseudo-ginseng medicament night cream carries out according to step below:
The extraction of the first step, Chinese medicine ingredients;
Utilize Radix Notoginseng to extract arasaponin, adopt that ultrasonic extraction, ethanol refluxing process extract, cellulose enzyme solution is extracted, pectinase enzymatic hydrolysis method is extracted, enzymolyzing alpha-amylase method is extracted, complex enzyme zymohydrolysis method is extracted and half bionical-enzymolyzing alpha-amylase extraction method;
Radix Salviae Miltiorrhizae is utilized to extract Radix Salviae Miltiorrhizae extract, first Radix Salviae Miltiorrhizae powder is broken into coarse powder, add alcohol heating reflux and extract three times, filter, merging filtrate, decompression recycling ethanol at 60 ° of C temperature, being condensed into relative density is 1.30-1.35 thick paste, colourless to washing liquid by hot water wash, at 80 ° of C temperature, carry out drying, be ground into fine powder, make Radix Salviae Miltiorrhizae extract for subsequent use;
Utilize Radix Angelicae Sinensis to extract Radix Angelicae Sinensis extract, adopt water extraction, Radix Angelicae Sinensis 100 g is broken, dry at the temperature of 80 DEG C, then pulverize, cross 40 mesh sieve; Divide with distilled water again and carry out lixiviate 3 times, 3 amount of water be respectively Radix Angelicae Sinensis heavy 10,6,4 times; Each extraction temperature is 100 DEG C, time 30 min; Merge 3 lixiviating solution, adopt 1 500 r/min centrifuges to carry out centrifugal treating 30 min, then carry out filtrate process, again adopt 10 000 r/min centrifuges to carry out centrifugal treating 15 min, again carry out filtrate process, eventually pass rotary evaporation and obtain Radix Angelicae Sinensis extract concentrated solution;
Utilize Semen Armeniacae Amarum to extract Semen Armeniacae Amarum saponin, first, Semen Armeniacae Amarum is carried out drying, make described amygdalate water activity be 0.10-0.70; Then, 10 order-120 orders are crushed to; Under the condition keeping water activity constant, extract Semen Armeniacae Amarum oil; Be that the ethanol water of 50%-95% carries out separation and Extraction to the Semen Armeniacae Amarum dregs of rice by mass percentage concentration, obtain Semen Armeniacae Amarum saponin and Almond Proteins;
Second step, to prepare burden according to formula;
Arasaponin, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, glycerol, peregal, lanoline, polyoxyethylene sorbitol acid anhydride olein, Semen Armeniacae Amarum saponin, mud pool tortoise beetle ester and water is comprised according to pseudo-ginseng medicament night cream; The mass percent of each component is: arasaponin 24 parts, Radix Salviae Miltiorrhizae extract 15 parts, Radix Angelicae Sinensis extract 15 parts, glycerol 7 parts, peregal 5 parts, lanoline 3 parts, polyoxyethylene sorbitol acid anhydride olein 3 parts, Semen Armeniacae Amarum saponin 2 parts, mud pool tortoise beetle ester 0.2 part, surplus is that water carries out proportioning;
3rd step, sterilization treatment;
4th step, at 85 DEG C of temperature, carry out emulsifying;
5th step, mixing leave standstill 30min;
6th step, to stir, at room temperature cool;
7th step, inspection of semifinished product microorganism ph value; By ph value modulation 6.8;
8th step, fill, packaging, inspection, warehouse-in.
The present invention is with Radix Salviae Miltiorrhizae, Semen Armeniacae Amarum, Radix Angelicae Sinensis and valuable ingredient of Chinese medicine Radix Notoginseng primary raw material, extract Radix Salviae Miltiorrhizae extract, Semen Armeniacae Amarum saponin, Radix Angelicae Sinensis extract and saponin, carry out rational proportion, be fitted to each other, synergy, makes pseudo-ginseng medicament night cream, realizes resisting age of skin, improves skin whitening capability, can skin be tightened up, promote the absorption of nutrient substance, make skin white touched with red, delicate and charming pleasant; Especially the interpolation of Radix Scutellariae extract further increases the antibacterial effect of pseudo-ginseng medicament night cream, expands the use crowd of pseudo-ginseng medicament night cream further, improves the suitability of pseudo-ginseng medicament night cream.
The content that the present invention is described by embodiment, without departing from the present invention, various conversion and equivalent replacement can also be carried out to patent of the present invention, therefore, patent of the present invention is not limited to disclosed specific implementation process, and should comprise the whole embodiments fallen within the scope of Patent right requirement of the present invention.