CN100547063C - Semen Litchi extract is killed application in the soap of acarid in preparation - Google Patents

Semen Litchi extract is killed application in the soap of acarid in preparation Download PDF

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CN100547063C
CN100547063C CNB2006101116693A CN200610111669A CN100547063C CN 100547063 C CN100547063 C CN 100547063C CN B2006101116693 A CNB2006101116693 A CN B2006101116693A CN 200610111669 A CN200610111669 A CN 200610111669A CN 100547063 C CN100547063 C CN 100547063C
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soap
extract
semen litchi
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litchi extract
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CN1908144A (en
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乔爱娴
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SINOMEDICINE (BEIJING) PHARMACEUTICAL SCIENTIFIC CO Ltd
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Abstract

The invention belongs to the household chemicals field, specifically disclose a kind of soap, it is to be that raw material is made by special plant.This soap has the effect of killing acarid and killing fungi, has good market outlook.

Description

Semen Litchi extract is killed application in the soap of acarid in preparation
[technical field]
The invention belongs to the household chemicals technical field, be specifically related to the application of Semen Litchi extract in killing the soap of acarid.
[background technology]
Semen Litchi is the mature seed of Sapindaceae aiphyllium plant lichee (Litchi chinsis Sonn.).Main product in Fujian, ground such as Guangdong, Guangxi.Pluck mature fruit summer, remove pericarp and meat arillus, clean, dry.Give birth to or salt solution process usefulness.Time spent smashes.Hot, the little hardship of Semen Litchi flavor, temperature.Return liver, stomach through being mainly used in hernia pain, painful and swollen testis.This product catharsis of working hard has the merit of dispersing stagnated hepatoqi, promoting QI to circulate and dispersing the agglomeration of the pathogens, dispersing cold for relieving pain.Semen Litchi is controlled cold hernia pain, can be equal to usefulness with sweet fennel, Medcinal Evodia Fruit, tangerine seed, and ball disappears in the hernia as " Beijing's Chinese traditional patent formulation selected works ".Control painful and swollen testis, many and tangerine seed, Szechwan Chinaberry Fruit are equal to usefulness.Semen Litchi also can be used for gastral cavilty pain of a specified duration, dysmenorrhoea, puerperal abdonimal pain.It is logical that the hot row of this product hardship is let out temperature, and dispersing the stagnated liver-QI for regulating the stomach, regulating QI to relieve pain effect are arranged.Semen Litchi is controlled the gastral cavilty pain of a specified duration of depression of liver-QI, liver and stomach not get along well, can grind clothes into powder with the banksia rose, looses as the Jing-Yue Complete Works litchi is fragrant, control the dysmenorrhoea and the puerperal abdonimal pain of stagnation of QI due to depression of the liver blood stasis, can grind clothes into powder with perfume (or spice) limit, diffusing bitterly as " married woman's good recipe " tin, or be equal to usefulness with Ligusticum wallichii, Radix Angelicae Sinensis, radix bupleuri.
Acarid less than 0.5 millimeter, belongs to acarina usually, and is distributed more widely, and kind is more, and more common have a gamasid, trombiculid, and the type of wriggling mite, the dirt mite, itch mite, flour mite etc., common acarid and hazardness thereof are listed in table 1.As shown in Table 1, acarid can colonize in human body skin, lives in the object that contacts with the people, exists in dust and the grain, its hazardness is also very big, they not only self cause the human body skin disease, diseases such as allergic rhinitis and asthma to being destroyed by parasitic body (host), but also propagate other disease. along with urban industryization, environmental pollution, koniology increases, and causes the factor of disease more important by acarid. therefore remove approval and the acceptance that the mite series products obtains consumers in general in recent years.
Table 1 acarid and feature thereof and hazardness
Figure C20061011166900031
Figure C20061011166900041
It is few that the available health is removed the mite raw material in the market, and the usage quantity of the indivedual effectively raw materials of minority is but very high.Because raw material and technology limitation, many products are often just done a conception of species, do not add effective composition, do not reach the target of driving the acarid that goes out at all. therefore good raw material and technology seems extremely important for preventing and treating acarid.
Fungus-caused disease is divided into shallow and infects and deep infection.Shallow fungi infestation in the world many areas very general, belong to propagated common frdquently encountered disease; Mainly cause, can invade the keratoprotein tissue of skin, hair follicle and nail, account for about 90% of fungi infestation incidence by Epidermophyton, the mould Pseudomonas of little spore and trichophyton.Well-known have favus of the scalp, ringworm of the body, jock itch, tinea manus and pedis, tinea versicolor and a tinea unguium, and mining area operator and the crowd who lives in the warm environment have generation more, though easily ignored by people, also are the persistent ailments of making us very worried.
American documentation literature US2004/0101508A1 discloses the purposes of extract aspect makeup and medicine of Fructus Litchi.Chinese patent literature (200410022559) provides Fructus Litchi extract and preparation method thereof, and this invention also provides the application of this Fructus Litchi extract in medicine, protective foods and makeup.But to the deep development of Semen Litchi extract, especially Semen Litchi extract does not have document to mention in the application of soap, does not have product open yet.Zheng Linying etc. reported Semen Litchi have suppress hepatitis B surface antigen(HBsAg), effect (Chinese materia medica journal, 1998 (5): 51-53) such as lowering blood glucose, enhancing mouse liver albumen and RNA be synthetic; (Chinese Journal of New Drugs, 2000 (1): 14-16) reported that also Semen Litchi has regulating blood fat and antioxygenation such as Pan Jing clanging or clanking sound except above effect.
[summary of the invention]
The objective of the invention is to turns waste into wealth annual about 500,000 tons Semen Litchi, and development and use are used to prepare soap, and this soap has the effect of killing acarid and killing fungi.
Another object of the present invention is to provide the preparation method of this soap.
In the soap of the present invention, the weight ratio of Semen Litchi extract in soap is 0.1-30%, preferred 0.5-20%, most preferably 1-10%.
Above-mentioned Semen Litchi extract is that the mixed solvent extraction of Semen Litchi with the second alcohol and water obtained.
Semen Litchi extract among the present invention also can adopt commercially available product (existing at present Semen Litchi extract is sold), can also obtain by other organic solvents or water extraction.
Above-mentioned soap can also add Herba Leonuri extract, Radix Salviae Miltiorrhizae extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, wheat extract, Radix Polygoni Multiflori extract, Radix Ginseng extract, pearl, pearl micropowder, Rhizoma Atractylodis Macrocephalae extract, wolfberry fruit extract, Radix Saposhnikoviae extract, Radix Angelicae Dahuricae extract, Radix Astragali extract, Rhizoma Dioscoreae extract, Semen Cuscutae extract, Radix Rehmanniae extract, alfalfa extract, Seaweed Extract liquid, Aloe extract, Radix Arnebiae extract, apricot peach extract, the arnica montana extract, bay extract extract, the Fructus Citri Sarcodactylis extract, the sprout of birch extract, the burdock extract, the mary bush extract, Camellia extract, camomile extract, green algal extract, Radix Glycyrrhizae extract, Caulis Hederae Sinensis extract, Herba Euphrasiae Regelii extract, Oenothera oil, Fructus Foeniculi extract, Rhizoma Zingiberis Recens extract, in Semen Ginkgo extrac and the root of Gentiana lutea root extract one or more.
Above-mentioned soap comprises: common soap, perfumed soap, shaving soap, disinfectant soap, laundry soap, deodorant soap, medicated soap, anti-perspirant soap.
That above-mentioned soap can be is solid-state, any one form in the powder attitude, liquid state.
The preparation method of soap of the present invention is: water and the mixed solvent extraction of alcoholic acid were 2-3 time after Semen Litchi was pulverized, each 1-2 hour, the temperature of extracting is 55-70 ℃, concentrated after drying promptly gets Semen Litchi extract, with the Semen Litchi extract irradiation sterilization after, the dressing that adds soap, stirring and evenly mixing, packing is promptly.
The water content of the Semen Litchi extract among the preparation method of above-mentioned soap is controlled at 2.5-3.5%.
Because Guangdong and Guangxi Provinces, Fujian and Taiwan lichee output are huge, many mountain areas, the lichee place of production and hills, have inconvenient traffic, and lichee requires very harsh to storage and transport condition, often occur going mouldy owing to lichee can not be caused by place of production outward transport in time, at this moment pulp and lichee kind skin have not all had utility value, Semen Litchi can also add in the soap by drying, sterilization and pulverizing back or processing extraction only, turn waste into wealth, produce bigger economic worth, also can increase farmers' income for the lichee grower retrieves a loss.
China's lichee output is huge, and lichee output was about 1,500,000 tons in 2005, and resource is very abundant, because the difference of lichee kind accounts for lichee gross weight 1/3 with Semen Litchi and calculates, annual China just has 500,000 tons of Semen Litchi resources to develop.From the raw material as soap, Semen Litchi has than the better advantage of Fructus Litchi, says that from content of effective difference of them is little, but because Fructus Litchi is in the fruit outside, contacts with air, and activeconstituents is oxidized easily; And lichee is as a kind of fruit, by people edible after, pericarp is difficult to collect, the gross weight ratio that Fructus Litchi accounts for litchi fruits is little; And Semen Litchi weight is big, is easy to collect after eating; Directly Semen Litchi is taken out when also having businessman to produce canned litchi, be more convenient for the collection of Semen Litchi like this.
Soap is good carriers that sterilization removes the mite product as important cleaning supplies.The application of Semen Litchi extract in soap is the good combination of the two.Other composition consistency of Semen Litchi extract and soap is good, and can tolerate the alkalescence of soap.Semen Litchi extract adds in soap, can be directly and neat soap mixed, add other corresponding additive, through milling, shaping, cutting, operations such as printing can obtain finished product.A typical soap prescription is as follows:
Component content %
Semen Litchi extract 5
Titanium dioxide 0.25
EDTA-4Na 0.20
Essence 0.001
Neat soap balance to 100
This prescription soap remove the mite performance, with reference to agricultural chemicals inspection (give birth to and survey) (2003) No. 45 standards of letter, detect Semen Litchi extract soap and drive mite, knock down and miticidal effect, the result is as follows:
Table 2 5% Semen Litchi extract soap drives mite effect (1mg/cm 2)
Figure C20061011166900061
Table 3 5% Semen Litchi extract is knocked down and miticidal effect (1mg/cm 2)
Figure C20061011166900062
Above-mentioned experimental result shows, 0.5% Semen Litchi extract remove that the mite soap removes mite and the mite effect of going out is all better, have the outstanding mite ability of removing.
Lichee fires one's imagination owing to the well-known phrase of " rides the human society imperial concubine laughs at, and nobody knows lichee " since ancient times, becomes a kind of and beautiful fruit of becoming attached to, and Semen Litchi really is used to beautify people's life but also have no talent at present, also is not used in preparation soap.
The present invention verifies by experiment, it is that various compositions comprehensively play a role in the Semen Litchi extract with the effect effect of killing fungi that acarid is killed in soap performance among the present invention, rather than a certain or a certain compounds plays a role, therefore Semen Litchi extract is as a kind of raw material of soap, has the incomparable effect of other soap, especially has significant improvement effect aspect the effect of going to kill acarid and kill fungi, in addition, Semen Litchi extract also has favorable compatibility, also can make soap by compatibility with other plant or plant milk extract, also have the effect of killing acarid and killing the effect of fungi, wherein the effect of Semen Litchi extract is indispensable.
[embodiment]
Following embodiment further describes the present invention, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.
The preparation of embodiment 1-Semen Litchi extract
500 gram Semen Litchis, the mixed solvent of pulverizing the two weight ratio of back water and acetone and being 1: 2 extracts 2-3 time 1-2 hour at every turn for 2.5 liters, the temperature of extracting is 55-65 ℃, concentrates the back under 70 ℃ of conditions, vacuum drying oven 6 hours, promptly get Semen Litchi extract, water content is 2.8%.
The preparation of embodiment 2-Semen Litchi extract
500 gram Semen Litchis, the mixed solvent of pulverizing the two weight ratio of back water and ethanol and being 1: 3 extracts 2-3 time 1-2 hour at every turn for 3 liters, the temperature of extracting is 55-70 ℃, concentrates the back under 80 ℃ of conditions, vacuum drying oven 5 hours, promptly get Semen Litchi extract, water content is 2.9%.
The preparation of embodiment 3-Semen Litchi extract
500 gram Semen Litchis, the mixed solvent of pulverizing the two weight ratio of back water and acetone and being 1: 2 extracts 2-3 time for 2.5 liters, and each 1-2 hour, the temperature of extraction was 55-70 ℃, and concentrated, spraying drying promptly get Semen Litchi extract, and water content is 3.1%.
The preparation of embodiment 4-Semen Litchi extract
500 gram Semen Litchis, the mixed solvent of pulverizing the two weight ratio of back water and acetone and being 1: 3 extracts 2-3 time for 3 liters, each 1-2 hour, the temperature of extracting is 55-70 ℃, concentrate, after the spraying drying under 75 ℃ of conditions, vacuum drying oven 5 hours promptly gets Semen Litchi extract, and water content is 3.0%.
The preparation of embodiment 5-Semen Litchi extract
500 gram Semen Litchis, the mixed solvent of pulverizing the two weight ratio of back water and ethyl acetate and being 1: 3 extracts 2-3 time for 3 liters, each 1-2 hour, the temperature of extracting is 55-70 ℃, concentrate, after the spraying drying under 50 ℃ of conditions, vacuum drying oven 8 hours promptly gets Semen Litchi extract, and water content is 2.5%.
The preparation of embodiment 6-Semen Litchi extract
500 gram Semen Litchis, the mixed solvent of pulverizing the two weight ratio of back water and acetone and being 1: 20 extracts 2-3 time for 2.5 liters, and each 1-2 hour, the temperature of extraction was 55-70 ℃, and concentrated, spraying drying promptly get Semen Litchi extract, and water content is 3.5%.
The preparation of embodiment 7-Semen Litchi extract
500 gram Semen Litchis, the mixed solvent of pulverizing the two weight ratio of back water and acetone and being 20: 1 extracts 2-3 time for 3 liters, each 1-2 hour, the temperature of extracting is 55-70 ℃, concentrate, after the spraying drying under 50 ℃ of conditions, vacuum drying oven 5 hours promptly gets Semen Litchi extract, and water content is 3.0%.
Embodiment 8-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 1g (embodiment 1), 650g neat soap, 200g lanolin, 144g propylene glycol, 4g retinoic acid, 1g soap compound.
Preparation: retinoic acid and Semen Litchi extract be ground into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing lanolin, propylene glycol, soap compound, and constantly stir and grind, shaping, cutting is printed, promptly.
Embodiment 9-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 5g (embodiment 2), 4.5g Flos Pelargonii essential oil, 740g neat soap, 210g lanolin, polyvinyl alcohol 30g, EDTA-2Na0.5g and 10g titanium dioxide
Preparation: titanium dioxide and EDTA-2Na and Semen Litchi extract be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing lanolin, polyvinyl alcohol, Flos Pelargonii essential oil, and constantly stir and grind, shaping, cutting, print, promptly.
Embodiment 10-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 50g, 4.5g ethyl cellulose, 700g neat soap, 210g lanolin, polyvinyl alcohol 25g, EDTA-2Na10g and 0.5g titanium dioxide.
Preparation: ethyl cellulose, titanium dioxide and EDTA-2Na be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, the lanolin, polyvinyl alcohol, soap compound, Semen Litchi extract and continuous stirring that add fusing are subsequently ground shaping, cutting, print, promptly.
Embodiment 11-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 100g, 650g neat soap, 210g lanolin, polyvinyl alcohol 34g, EDTA-2Na5g and 1g titanium dioxide
Preparation: titanium dioxide, EDTA-2Na and Semen Litchi extract be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing lanolin, polyvinyl alcohol, soap compound, and constantly stir and grind, shaping, cutting, print, promptly.
Embodiment 12-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 200g (embodiment 5), 4.5g Radix Ginseng extract, 620g neat soap, 150g lanolin, polyvinyl alcohol 20g, EDTA-2Na0.5g and 5g titanium dioxide.
Preparation: ethyl cellulose, titanium dioxide, EDTA-2Na, Semen Litchi extract and wheat extract be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing lanolin, polyvinyl alcohol, soap compound, and constantly stir and grind, shaping, cutting, print, promptly.
Embodiment 13-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 100g (embodiment 5), 4.5g Radix Ginseng extract, 620g neat soap, 215g lanolin, EDTA-2Na0.5g and 10g titanium dioxide.
Preparation: Semen Litchi extract, wheat extract, titanium dioxide and EDTA-2Na be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing lanolin, soap compound, and constantly stir and grind, shaping, cutting, print, promptly.
Embodiment 14-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 50g (embodiment 4), 4.5g ethyl cellulose, 700g neat soap, 120g lanolin, 90g sodium lauroyl sareosine, polyvinyl alcohol 25g, EDTA-2Na0.5g and 10g titanium dioxide.
Preparation: ethyl cellulose, Semen Litchi extract, sodium lauroyl sareosine, titanium dioxide and EDTA-2Na be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing lanolin, polyvinyl alcohol, soap compound, and constantly stir and grind, shaping, cutting, print, promptly.
Embodiment 15-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 100g, 4.5g Radix Ginseng extract, 670g neat soap, 200g stearic acid, polyvinyl alcohol 15g, EDTA-2Na0.5g and 10g titanium dioxide.
Preparation: titanium dioxide, EDTA-2Na, Semen Litchi extract and Radix Ginseng extract be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing lanolin, polyvinyl alcohol, soap compound, and constantly stir and grind, shaping, cutting, print, promptly.
Embodiment 16-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 10g, 4.5g wheat extract, 760g neat soap, 200g glyceryl ether sodium sulfonate, polyvinyl alcohol 20g, EDTA-2Na0.5g and 5g titanium dioxide.
Preparation: titanium dioxide, EDTA-2Na, Semen Litchi extract glyceryl ether sodium sulfonate and wheat extract be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing lanolin, polyvinyl alcohol, soap compound, and constantly stir and grind, shaping, cutting, print, promptly.
Embodiment 17-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 10g, 4.5g Radix Arnebiae extract, 430g neat soap, 300g glycerine, 220g paraffin, polyvinyl alcohol 25g, EDTA-2Na0.5g and 10g titanium dioxide.
Preparation: titanium dioxide and EDTA-2Na, Semen Litchi extract and Radix Arnebiae extract be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, add subsequently fusing paraffin, glycerine, polyvinyl alcohol, soap compound, and constantly stir and grind, can, promptly.
Embodiment 18-contains the preparation of Semen Litchi extract soap
Prescription: the Semen Litchi extract of 300g (embodiment 3), 4.5g dichloroacetic acid, 340g neat soap, 120g lanolin, 200g glycerine, polyvinyl alcohol 25g, EDTA-2Na0.5g and 10g titanium dioxide.
Preparation: titanium dioxide and EDTA-2Na and Semen Litchi extract be broken into be encased in the intermittent type spice machine with neat soap after fine powder is crossed 100 mesh sieves, the lanolin, glycerine, dichloroacetic acid, polyvinyl alcohol, soap compound and continuous stirring that add fusing are subsequently ground, can, promptly.
Experimental example 1-human safety (skin irritation) test
1 test objective
Detection is tried the possibility that thing causes the human body skin untoward reaction, and the effect of being tried thing is carried out preliminary assessment.
2 test fundamental principles
2.1 select qualified volunteer object on probation.
2.2 according to the type and the character of makeup, allow the actual use of experimenter be subjected to test product, tried the security (skin irritation) of thing to human body with evaluation.
3 experimenters' selection
3.1 select volunteer that the Pass Test of 18-60 year requires as study subject.
3.2 can not select following situation person as the experimenter: a nearly week uses antihistaminic or uses immunosuppressor person in nearly one month; Tried the position in nearly two months and used any anti-inflammatory drug person; The experimenter suffers from the sick clinical person of not healing of inflammatory skin; The insulin-dependent diabetes patient; The asthma of receiving treatment or other chronic respiratory system diseases patient; The person that in nearly 6 months, accepts the anticancer chemotherapy; Immune deficiency or autoimmune disorder patient; Lactation or gravid woman; Bilateral mastectomy and bilateral axillary lymph knot excision person; Wait to try the position influences test-results owing to scar, pigment, atrophy, nevus flammeus or other flaw judgement person at skin; Participate in other clinical trial person; The extremely sensitive person of physique; Non-aspiration participator maybe can not finish specified content person by test requirements document.
4 skin reaction grade scales: see Table 1.
Table 3 human body tryout skin adverse reaction grade scale
Figure C20061011166900101
5 test methods
Press subject enrollment experimenter 50 examples (male sex's 25 examples, women's 25 examples), the time on probation is 1 month.On 3 days skin, mark, be coated with same position with 0.5 * 0.5 centimetre of embodiment 8-18 separate application in experimenter's forearm inboard at every turn.Observe 1 experimenter's skin reaction every 1 day, press table 1 skin adverse reaction grade scale record result.
6 result safety evaluations:
Nothing 1 example has the skin adverse reaction more than 1 grade or 1 grade among the of the present invention 50 routine experimenters, judges that soap of the present invention has without any untoward reaction human body.
Experimental example 2-soap is to antifungic action
Use group: clean the affected part with embodiment 12.Choose caused skin infections person's 43 examples of fungi, the male sex's 22 examples wherein, women's 21 examples.
The blank group: common soap cleans the affected part.Choose caused skin infections person's 18 examples of fungi, the male sex's 10 examples wherein, women's 8 examples.。
4.2 methods of treatment
Use group: the embodiment 12 an amount of affected parts of cleaning, adhered to using 15 days at every day 3 times.
The blank group: common soap cleans the affected part, every day 3 times, adheres to using 15 days.
4.3 therapeutic evaluation standard: adopt " TCM Dermatology illness diagnosis criterion of therapeutical effect ".Cure: skin decreases and disappears fully, and the surface of a wound heals fully, no longer includes new rash and occurs.Take a turn for the better: skin decreases healing more than 50%.Do not heal: skin decreases as before, seemingly has new rash constantly to occur or healing skin damage deficiency.
4.4 treatment result sees Table 2
The caused skin infections curative effect statistics of 12 pairs of fungies of table 2 embodiment
Figure C20061011166900111
5 discuss
The present invention has the broad-spectrum antifungal effect, and deep fungal and part superficial fungi are had good killing and restraining effect, and the present invention is used for the skin affected part, suppresses bacterium, fungi growth and breeding, and antipruritic, anti-allergic effects is played on the cleaning skin surface simultaneously.
Experimental example 3-soap is to the removal effect of acarid
Prepared soap is on probation 48 male sex university students, and being divided into is 6 groups, every group 8 people, and promptly A group (blank group), B group (embodiment 9), C group (embodiment 10), D group (embodiment 11), E group (embodiment 12), F organize (common soap).Ginseng survey personnel and experimenter do not know the kind (double-blind method) of employed soap.
Experimental technique: before 6 groups of male sex university students use, after rising morning, put on the skin gently one time at face, then hygenic towelette is detected acarid quantity, record respectively under 100 power microscopes with hygenic towelette.6 groups of male sex university students use the corresponding soap of each group, every day 3 times.Continue after 15 days, with hygenic towelette at face gently put one time after rising the 16th day morning, then hygenic towelette detected acarid quantity respectively under 100 power microscopes, is recorded in microscopically and detects acarid quantity, record, the situation that detects of observing acarid.Effect is divided into 4 grades: 1 grade: hygenic towelette does not have acarid and detects, 2 grades: hygenic towelette has 1 acarid to detect 3 grades: hygenic towelette has 2 acarids to detect 4 grades: hygenic towelette has 3 or 3 above acarids to detect.Concrete data see Table 3
Table 3 is respectively organized experimenter's acarid situation
Figure C20061011166900112
Figure C20061011166900121
Above data declaration soap of the present invention has unusual effect to removing acarid.

Claims (5)

1. Semen Litchi extract is killed application in the soap of acarid in preparation, the preparation method of wherein said Semen Litchi extract is: water and the mixed solvent extraction of alcoholic acid were 2-3 time after Semen Litchi was pulverized, each 1-2 hour, the temperature of extracting is 55-70 ℃, concentrate after drying, described Semen Litchi extract weight ratio is 0.1-30%.
2. application according to claim 2, the weight ratio that it is characterized in that Semen Litchi extract in the described soap is 0.5-20%.
3. application according to claim 3, the weight ratio that it is characterized in that Semen Litchi extract in the described soap is 1-10%.
4. according to any described application of claim 1-3, it is characterized in that described soap is selected from: common soap, perfumed soap, shaving soap, disinfectant soap, deodorant soap or anti-perspirant soap.
5. according to any described application of claim 1-4, it is characterized in that described soap is any one form in solid-state or liquid.
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