CN101347395B - Chinese medicine floral water for preventing and treating bite by mosquitos - Google Patents
Chinese medicine floral water for preventing and treating bite by mosquitos Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine floral water for preventing and treating mosquito and insect bites, which comprises 0.001-0.5% of dipotassium glycyrrhizinate, 0.001-0.5% of baicalin, 0.01-5% of Chinese medicinal herb extracts, wherein the Chinese medicinal herb extracts are selected from two or more of the following extracts: trumpet creeper extract, purslane extract, Chinese violet extract, wild chrysanthemum flower extract, shrubby sophora extract and Chinese dittany bark extract. The traditional Chinese medicine floral water can be prepared by using ethanol and water with the proportion being around 60%-85%:40%-15%, wherein the floral water further comprises 0.5%-3% of green tea essence. The traditional Chinese medicine floral water can be made into a spray or an aerosol for external use and is directly sprayed on skin when in use. The traditional Chinese medicine floral water has the effects of antibiosis, relieving itching, reducing swelling, alleviating pain, preventing mosquito, dispelling prickly heat, removing summer-heat and refreshing, and can be applied to the daily skin care of adults and children.
Description
Technical field
The present invention relates to a kind of Chinese medicine floral water, relate in particular to a kind of Chinese medicine floral water of preventing and treating mosquito bite.
Background technology
(Mosquito-bite dermatitis MBD), is the allergic skin inflammation that is caused by mosquito bite to mosquito bite dermatitis, is the main type of insect dermatitis.In summer and autumn, mosquito is very active, and the people tends to occur the same erythema of welt after by mosquito bite, in the middle of the erythema vesicle is arranged, and is snapped the zone and mainly concentrates on lower limb, lower back.If pruritus is serious, scratching can make original dermatitis increase the weight of, and wound is scratched bigger and bigger, causes prurigo, eczema etc. at last, and causes secondary skin infection and skin ulcer, can stay cicatrix because of pigmentation after the recovery from illness.
Skin problem such as mosquito bite and miliaria usually takes place together, has not only had a strong impact on daily life, and might cause severe anaphylactic reaction and general toxicity, merits attention.According to statistics, nearly more than the 3000 kinds of mosquitoes in the whole world.Kind of mosquito was widely distributed surplus China had 300.Common mosquito has Anopheles sinensis Anopheleshyrcanus sinensis, culex pipiens pallens Culex pipiens pallens, Aedes albopictus Aedes albopictus three classes.For majority, mosquito bite causes that pruritus creates disturbances to, and needs to use article of everyday use, carries out home care as floral water etc.
Modern dermatological studies proves, the i.e. property sent out welt that mosquito bite causes and tardy property pimple are respectively the reactions of anaphylaxis of skin I type and IV type pimple.Early stage in morbidity, as people during by mosquito bite, mosquito is injected skin with saliva, xenogenesis sialoprotein/polypeptide that it contains, (α-glucosidase), make human sensitization can detect specific immune globulin molecule IgE and IgG in adult or serum of children with glucosidase as adenosine triphosphatase (apyrase), wherein IgE mainly causes welt and erythema, and IgG is relevant with the dermoreaction degree; Bite back 30-45 minute, and skin allergy medium histamine (histamine) and leukotriene (leukotriene C4, LTC4) secretion increases, and causes type i allergic reaction jointly, and that skin occurs rapidly is red, swollen, hot, inflammatory symptom bitterly.Approximately after 4-6 hour, can postpone the reaction of secondary IV type pimple, and continue several days time.No matter be that morbidity is early stage, still in period of delay, violent pruritus all appears in the skin affected part.Therefore, effective nursing skin mosquito bite, need to adopt have antiinflammatory, the floral water product of antiallergic, effect such as antibiotic, or multi-acting floral water, in time the control dermoreaction recovers skin health.
Floral water (Florida water) is that a kind of essence consumption is few, is used for the summer and autumn miliarias of dispelling after taking a shower and refreshes oneself, prevents and treats the hygienic article of mosquito bite.Although national floral water kind brand is a lot, but its traditional raw material all is mainly Mentholum, Borneolum Syntheticum, thymol, Camphora, essence, ethanol and deionized water, refrigerant except that having, fragrance and the miliaria function of dispelling, the insect dermatitis and the skin infection/ulcer that cause for mosquito bite have little effect, and its product differentiation is that mainly the odor type selection is different with adjusting incense process.With reference to the multi-acting floral water standard, China's existing market sell goods though characteristics are respectively arranged, owing to lack the guidance of modern medical theory and Chinese medical theory, mainly are positioned the functions such as miliaria, anophelifuge of dispelling, and generally lack the skin-care function of control insect dermatitis.Generally, the existing floral water product of China also needs to weed out the old and bring forth the new, improve performance, better to satisfy consumer demand, development market in the mosquito bite home care.
In the skin surgery field, China's Chinese medicine and pharmacy has accumulated deep theoretic knowledge and abundant clinical experience since ancient times.The insect dermatitis that mosquito bite causes belongs to Chinese medicine " evil insect stings " [" Waike Zhengzong, Orthodox Manual of External Diseases "] category, and another name insect bite wound, insect bite dermatitis, evil insect stings wound etc. are commonly called as injure of insect bite.Disliking insect stings is the general name that multiple poisonous insect is hurted sb.'s feelings, and mainly comprises mosquito, Scolopendra, penetrates the worker, scorpion, honeybee etc.The lighter's pruritus, serious part or whole body poisoning symptom appear in weight person's causalgia.Behind the mosquito bite, allly have an itch from the beginning of the affected part is rubescent, welt is arranged, there is vesicle on the top, perhaps insect bite vestige, the then pruritus and pain occurring alternately that continues, scarlet overflow swollen, red tongue, tongue is white, slippery and rapid pulse, its disease belongs to damp and hot poison and attacks card.Motherland's medical science is thought, " the lung master meter closes fur outward ", " heart master blood ", " all sufferings skin ulcers all belong to heart-fire "; So, need to control from the cardiopulmonary opinion to the skin disorder that mosquito bite causes, adopt heat-clearing and toxic substances removing, the treatment by Chinese herbs of dehumidifying removing heat from blood can obtain good effect.
Summary of the invention
The technical issues that need to address of the present invention are: under China's traditional medical theory and modern medical theory guidance, a kind of Chinese medicine multi-acting floral water of preventing and treating mosquito bite is provided, its tool heat-clearing and toxic substances removing, dehumidifying removing heat from blood effect, or antiallergic, antibiotic, antiinflammatory, analgesia pharmacological action, can alleviate rapidly skin red, swollen, hot, bitterly, itch, can shorten the restore cycle, treatment the mosquito bite insect dermatitis, skin infection and the ulcer that cause.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine floral water of preventing and treating mosquito bite, contain the Chinese medicine active component of following percentage by weight: glycyrrhizic acid dipotassium 0.001-0.5%, baicalin 0.001-0.5%, Chinese medicine extract 0.01-10%.Wherein, Chinese medicine extract is selected from following heat-clearing and toxic substances removing, in the dehumidifying removing heat from blood class Chinese medicine two kinds or two or more: Flos Campsis extract, Herba portulacae extract, Herba Violae extract, Flos Chrysanthemi Indici extract, Radix Sophorae Flavescentis extract, Cortex Dictamni extract.
Wherein, active ingredient of Chinese herbs raw material baicalin of the present invention and glycyrrhizic acid dipotassium are daily chemical product, and raw material of Chinese medicine of the present invention is then for recording in " Chinese crude drug in the Chinese pharmacopoeia 2005 editions: 1. Flos Chrysanthemi Indici is the dry capitulum of feverfew Herba Dendranthematis indici Chrysanthemum indicum L.; 2. Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis Sophoraflavescens Ait.; 3. Flos Campsis is Bignoniaceae plant the reach the clouds flower of C.radicans (L.) Seem. of Campsis grandifloria (Thunb.) K.Schum or America of reaching the clouds; 4. Herba Violae is the whole herb with root of Violaceae Chinese violet Viola yedoensis Mak.; 5. Herba Portulacae is the herb of portulacaceous plant Herba Portulacae Portulacaoleracea L.; 6. Cortex Dictamni is the root bark of rutaceae shaggy-fruited dittany Dictamnus dasycarpus Turcz..
Chinese medicine extract of the present invention can adopt the herbal pharmaceutical technology (to adopt preparation methoies such as traditional reflux, merceration, percolation, and technologies such as up-to-date supercritical extraction, microwave extracting, membrance separation, macroporous resin) be prepared from, for example can in the crude drug of a certain amount of, definite composition, add certain amount of solvent, heating and refluxing extraction is 2 times respectively, time is respectively 2h, 1h, filters combining extraction liquid, reclaim solvent, concentrate, decolouring gets extracting solution or powdered extract; Also can be commercially available standard plant extract product, can be the intermediate that contains Radix Sophorae Flavescentis total alkaloids 80%, or contain the intermediate of matrine 98% or oxymatrine 98% as Radix Sophorae Flavescentis extract.
Described Chinese medicine active component can add daily-use chemical industry carrier, medical dressing and other compositions such as Mentholum and Borneolum Syntheticum, uses dissolve with ethanol according to a certain percentage, makes floral water.Consider product factors such as floral water stability, color and luster, clarity and self-preserving power, wherein, contain glycyrrhizic acid dipotassium 0.001-0.5%, baicalin 0.001-0.5%, Chinese medicine extract 0.01-10%.Be preferably: glycyrrhizic acid dipotassium 0.08%, baicalin 0.02%, Chinese medicine extract 1.0%.
Chinese medicine floral water of the present invention, available second alcohol and water preparation, the ratio of ethanol and water is about 60%～85%:40%～15%.
Chinese medicine floral water of the present invention, available green tea essence, consumption are 0.5%～3%.Described green tea essence is Citrus, the fragrance of a flower, draft dark green fragrant and hot odor type, and its perfume (or spice) is from Citrus, green tea, follows the fragrant fragrance of a flower by Herba Convallariae, Flos Rosae Rugosae, Polianthes tuberosa L. and jasmine, and bottom note is Moschus, the Radix Aucklandiae, succinum and Olibanum.
Chinese medicine floral water of the present invention can be made into spray or aerosol.
The present invention selects baicalin, glycyrrhizic acid dipotassium and Six-element Chinese medicine extract to make up, and makes each component effect collaborative mutually, can effectively alleviate the various skin discomforts that mosquito bite causes.The consumption of Chinese medicine floral water of the present invention and the course of treatment can be done suitably to adjust according to dosage form, user age, skin lesion degree, but after being generally mosquito bite every day spray 3～7 times, each 2 press, with 1～2 day be a course of treatment, can use 1～3 course of treatment continuously.
The present invention has following functional effect:
(1) Chinese medicine active component of the present invention is made up of 2 kinds of active ingredient of Chinese herbs and 6 flavor Chinese medicine extract, and Chinese medicine is thought: Flos Chrysanthemi Indici is cool in nature, and bitter in the mouth, suffering are returned lung, Liver Channel, have heat-clearing and toxic substances removing, dissipation carbuncle, dispelling wind suppressing the hyperactive liver effect; The Radix Sophorae Flavescentis hardship, cold, GUIXIN liver stomach warp has heat clearing and damp drying, the wind dispelling insecticide effect; Its property suffering of Flos Campsis, cold, return liver pericardium channel, have the promoting the circulation of blood blood stasis removing, the cooling blood, expelling wind effect; Herba Violae hardship, suffering, cold, the GUIXIN Liver Channel has heat-clearing toxin-expelling functions; The acid of Herba Portulacae property, cold, return the liver large intestine channel, have heat-clearing and toxic substances removing, the cooling blood for hemostasis effect; The Cortex Dictamni hardship, cold, return the taste warp, have heat-clearing and toxic substances removing, the removing damp to relieve itching effect, complete thus side has heat-clearing and toxic substances removing, damp eliminating removing heat from blood effect.
(2) Natural Medicine Chemistry and pharmaceutical research are found:
Baicalin (Baicalin) is a most important effective ingredient in the Radix Scutellariae, multiple gram positive bacteria, gram negative bacteria and spirillum etc. all there is inhibitory action, and have effects such as antiviral, antiinflammatory, antiallergic, antioxidation, be used for dermatopathies such as radiodermatitis, acne, capitis pityriasis, eczema, especially the skin allergy that causes for various allergy, skin pruritus and skin ulcer have the obvious treatment effect.
Glycyrrhizic acid (GlycyrrblzJe acid) is a most important effective ingredient in the Radix Glycyrrhizae, has glucocorticoid sample pharmacological actions such as stronger antiinflammatory, antiallergic, immunomodulating, antiviral, anti-cutaneous pigmentation, and does not have serious adverse reaction.In the treating skin disease field, chickenpox, herpes zoster, chronic urticaria, eczema, hebra's disease, psoriasis, atoipc dermatitis, alopecia areata, drug eruption etc. have been widely used in.
In addition, Cortex Dictamni contains alkaloid; Flos Campsis contains flavone, iridoid glycoside, phenylpropanol glycoside, alkaloid and volatile oil; Herba Portulacae is rich in flavone, polysaccharide, tannic acid, Saponin, vitamin, aminoacid and inorganic salt etc.; Flos Chrysanthemi Indici mainly contains volatile oil, flavone and chlorogenic acid etc.; Radix Sophorae Flavescentis contains alkaloid, volatile oil, flavone, lactone etc., all has in various degree antiallergic, antibiotic, antiinflammatory, analgesic activity, extensively outer be used for the various skin illness with red swelling of the skin pain, pruritus and ulcer.
(3) the green tea essence of this Chinese medicine floral water employing, innovation has developed tradition " rosemusk " odor type, and head perfume is the pure and fresh pleasant fragrance of Citrus, green tea; Middle perfume (or spice) has been admixed the noble elegant of Herba Convallariae, Beige ﹠ Rose, Polianthes tuberosa L. and jasmine; Bottom note then is the harmony blending of the Olibanum, the Radix Aucklandiae, Moschus and the succinum that have the east charm.The whole fragrance of a flower is elegant pleasant, and classics are not missed the season still again.
(4) customer test proves, this Chinese medicine floral water is except having the refrigerant miliaria of dispelling, fragrant refreshing function, and the skin discomfort that mosquito bite is caused has significant nursing function.The clinical practice result shows that this prescription and Chinese medicine multi-acting floral water thereof have special advantages and characteristic, are mainly:
1) have tangible antiinflammatory, anti-allergic effects, relieving itch was eliminated congestion and swelling pain in 2 days rapidly, made welt, pimple convergence;
2) have tangible antibacterial action, stop part and systemic infection;
3) have tangible skin maintenance effect, effectively the skin ulcer that causes is scratched in healing;
4) have littler skin irritation: owing to self stronger antiseptic property, can reduce consumption of ethanol, child preferably uses.
The specific embodiment
The invention will be further elaborated by the following examples:
Embodiment 1
Prescription one: contain glycyrrhizic acid dipotassium 0.004%, baicalin 0.001%, Flos Campsis extract 0.02%, Herba portulacae extract 0.02%, Herba Violae extract 0.02%, Flos Chrysanthemi Indici extract 0.02%, Cortex Dictamni extract 0.02%, essence (green tea essence) 0.5%, ethanol 65%, surplus is a deionized water.The floral water spray of making can be at 10 minutes rapid relieving itch, in 2 days, eliminate congestion and swelling pain.
Embodiment 2
Prescription two: contain glycyrrhizic acid dipotassium 0.001%, baicalin 0.01%, Herba portulacae extract 2%, Herba Violae extract 2%, Flos Chrysanthemi Indici extract 3%, Radix Sophorae Flavescentis extract 1%, Cortex Dictamni extract 2%, essence 0.5%, ethanol 65%, surplus are deionized water.The floral water spray of making can be at 10 minutes rapid relieving itch, in 2 days, eliminate congestion and swelling pain.
Embodiment 3
Prescription three: contain glycyrrhizic acid dipotassium 0.2%, baicalin 0.1%, Flos Campsis extract 0.05%, Herba Violae extract 5%, essence 0.5%, ethanol 60%, surplus is a deionized water.The floral water aerosol of making can be at 10 minutes rapid relieving itch, in 2 days, eliminate congestion and swelling pain.
Embodiment 4
Prescription four: contain glycyrrhizic acid dipotassium 0.1%, baicalin 0.05%, Flos Campsis extract 1%, Herba portulacae extract 1%, Herba Violae extract 1%, Radix Sophorae Flavescentis extract 1%, Cortex Dictamni extract 1%, essence 3%, ethanol 85%, surplus is a deionized water.The floral water spray of making can be at 8 minutes rapid relieving itch, in 2 days, eliminate congestion and swelling pain.
Embodiment 5
Prescription five: contain glycyrrhizic acid dipotassium 0.5%, baicalin 0.5%, Flos Campsis extract 2%, Cortex Dictamni extract 3%, essence 3%, ethanol 85%, surplus is a deionized water.The floral water aerosol of making can be at 7 minutes rapid relieving itch, in 2 days, eliminate congestion and swelling pain.
Embodiment 6
Prescription six: contain glycyrrhizic acid dipotassium 0.2%, baicalin 0.1%, Herba Violae extract 2%, Radix Sophorae Flavescentis extract 2%, Cortex Dictamni extract 2%, essence 3%, ethanol 85%, surplus is a deionized water.The floral water aerosol of making can be at 7 minutes rapid relieving itch, in 2 days, eliminate congestion and swelling pain.
Below, beneficial effect of the present invention is further elaborated by controlled clinical trial;
Test example 1
Materials and methods
(1) for the examination floral water: wait and measure dry Flos Chrysanthemi Indici, Herba Portulacae, Herba Violae, Radix Sophorae Flavescentis, Flos Campsis, six kinds of each 40g of raw material of Cortex Dictamni, be total to 240g, after suitably pulverizing, adding deionized water soaks into, 95% ethanol 500ml hot reflux 3 hours 1 time, filter, decolouring adds deionized water, regulate concentration of alcohol 65%, drug dipping 400～450ml in getting includes the about 40g of total extract, in addition extracting liquorice acid dipotassium 3.2g, baicalin 0.8g, evenly add the common miliaria of dispelling of 3.6L, in the mosquito-repellent perfume, low temperature (0-4 ℃) storage, ageing 5 days is filtered and is obtained the 4L floral water, is distributed into the floral water spray.
(2) for test worm kind and strain: Aedes albopictus (Aedes albopictus), normal strain, the 4-5 days female adult mosquitos in back that sprout wings are for measuring.
(3) assay method: 30 example aspiration consumers by female one-tenth mosquito bite after, local red, swollen, hot, bitterly, itch, foundation is bitten degree, quantity, position etc. the volunteer is divided into two groups at random: Chinese medicine floral water group and common floral water group, respectively 15 examples.The experimenter by mosquito bite after, spray mosquito bite place 3～7 time with Chinese medicine floral water and common floral water every day, each 2 press, and for three days on end, observation antipruritic effect, the effect of subsiding a swelling, remove miliaria effect, repelling effect.
Test finds, Chinese medicine floral water group average can be antipruritic in 10 minutes, but 1-2 days reducing swelling and alleviating pain, and preventing from scar and pigmentation; And do not add the common floral water of Chinese medicinal components, and only having aromatic mosquito-expelling and the refrigerant miliaria function of dispelling, it is not remarkable repeatedly to use the repellent antipruritic effect in its 2 days, shows the skin discomfort that this Chinese medicine composition causes mosquito bite, and nursing function is comprehensively, rapidly.
This Chinese medicine floral water can be made into external spraying agent or aerosol, directly is sprayed on the skin in use, and the effect of have anti-bacterial, anti-itching, reducing swelling and alleviating pain, the mosquito-proof miliaria of dispelling, relieving summer heat and refreshing oneself can be used for adult and child's skin daily nursing.Prove that through clinical trial this Chinese medicine floral water has stronger anti-bacterial, anti-itching, reducing swelling and alleviating pain effect than common floral water, be particularly suitable for the prevention and the treatment of insect dermatitis, skin infection and ulcer that mosquito bite causes.
Though the present invention is described by embodiment, embodiment is used for limiting the present invention.Those skilled in the art can make various distortion and improvement in the scope of spirit of the present invention, so being as the criterion of should being defined with the application's claim protection domain of protection scope of the present invention.
Claims (6)
1. Chinese medicine floral water of preventing and treating mosquito bite, its contained active component is glycyrrhizic acid dipotassium 0.001-0.5%, baicalin 0.001-0.5%, Chinese medicine extract 0.01-10%; Wherein, described Chinese medicine extract is selected from following two or more: Flos Campsis extract, Herba portulacae extract, Herba Violae extract, Flos Chrysanthemi Indici extract, Radix Sophorae Flavescentis extract, Cortex Dictamni extract.
2. Chinese medicine floral water as claimed in claim 1, its contained active component is: glycyrrhizic acid dipotassium 0.01-0.2%, baicalin 0.01-0.2%, Chinese medicine extract 0.1-5%.
3. Chinese medicine floral water as claimed in claim 1, its contained active component is: glycyrrhizic acid dipotassium 0.08%, baicalin 0.02%, Chinese medicine extract 1.0%.
4. as claim 1,2 or 3 described Chinese medicine floral water, with the preparation of second alcohol and water, the ratio of ethanol and water is 60%～85%: 40%～15%.
5. as claim 1,2 or 3 described Chinese medicine floral water, wherein also contain green tea essence, consumption is 0.5%～3%, and its perfume (or spice) is from Citrus, green tea, follow the fragrant fragrance of a flower by Herba Convallariae, Flos Rosae Rugosae, Polianthes tuberosa L. and jasmine, bottom note is Moschus, the Radix Aucklandiae, succinum and Olibanum.
6. as claim 1,2 or 3 described Chinese medicine floral water, make external spraying agent or aerosol.
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Cited By (1)
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| CN103655718A (en) * | 2012-08-30 | 2014-03-26 | 北京妙心堂医药科技有限公司 | Traditional Chinese medicine composition, preparation, and floral water and application method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103655718A (en) * | 2012-08-30 | 2014-03-26 | 北京妙心堂医药科技有限公司 | Traditional Chinese medicine composition, preparation, and floral water and application method thereof |
| CN103655718B (en) * | 2012-08-30 | 2015-02-18 | 北京妙心堂医药科技有限公司 | Traditional Chinese medicine composition, preparation, and floral water and application method thereof |
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