CN101700214B - Mosquito repelling liquid - Google Patents
Mosquito repelling liquid Download PDFInfo
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- CN101700214B CN101700214B CN2009102286854A CN200910228685A CN101700214B CN 101700214 B CN101700214 B CN 101700214B CN 2009102286854 A CN2009102286854 A CN 2009102286854A CN 200910228685 A CN200910228685 A CN 200910228685A CN 101700214 B CN101700214 B CN 101700214B
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- mosquito
- liquid medicine
- mosquito repelling
- effective
- repelling liquid
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to high-effective mosquito repelling liquid medicine which is characterized by comprising the following components by weight percent: 2%-7% of N, N-Diethyl-m-toluamide, 0.5%-2% of glycyrrhiza extract or glycyrrhizinic acid or glycyrrhetinic acid, 0.5%-2% of flavescens extract or matrine or oxymatrine or physiologically acceptable salt, 0.5%-2% of menthol or borneol and 0.01%-2% of plant essential oil. The high-effective mosquito repelling liquid medicine is the hormone-free preparation made of pure Chinese herbal medicine for external application and is prepared by uniquely combining the high-effective repellent with the components having the anti-inflammatory, the antibacterial and the antipruritic effect, thereby being innovative. The high-effective mosquito repelling liquid medicine of the invention has the function of repelling the mosquito, relieving the itching, refreshing the consciousness and protecting the skin from the insect bite and can repel the mosquito for 5-7 hours. The high-effective mosquito repelling liquid medicine of the invention is non-toxic to the skin and mucous membrane, can not cause the allergic reaction and has higher stability.
Description
Technical field
The present invention relates to filed of daily-use chemical industry, particularly have containing repellant and being equipped with the high-effective mosquito repelling liquid medicine of medicinal plants compositions of mosquito-expelling and antipruritic effect.
Background technology
Insecticide has caused a lot of problems to the mankind, except directly the mankind being caused direct harassing and wrecking and the injury, also can bring other worry in various degree.As influence sleep, and spread disease, will directly be constituted a threat to by the sting severe patient to human beings'health and life.Therefore, the human worry of always constantly resisting insecticide at the various effective ways of searching.
The topmost method of combat insects is to adopt insecticide.But insecticide has toxicity, and parasite killing is extreme method, and is not suitable for the generally use of human daily life.Often adopt insect repellent at present, thereby stop insecticide to stop the effect that reaches prevention at host's health in order to reach.Traditional synthetic repellant comprises: diethyltoluamide, dimethyl phthalate, indalone, anti-mosquito bite, Rutgers 612 etc.Diethyltoluamide is the nineteen forty-two exploitation, and it has the broad-spectrum repellent action, and most hematophagus is had effect preferably.At present, take all factors into consideration, in worldwide, be still the topmost insect repellent of human body from result of use, stability, economy etc.
Tend to scytitiss such as skin to the mankind brings redness, the pain of itching behind the sting, the lighter disappears after a couple of days, and is heavy then to be transformed into inflammatory skins such as dermatitis, eczema sick.The global sickness rate of eczema is up to 20%, and also is not less than 15% in China; Sufficient especially southern area is through moisture with damp and hot, and the eczema sickness rate is higher, accounts for the 15%-25% of department of dermatologry outpatient service amount.
In sum, what eczema was fallen ill extensively has some idea of, thereby this type of patient's local topical is treated, and seems particularly important.The medicine of state's such disease of internal therapy is many at present, and the Therapeutic Principle of subacute stage is antiinflammatory, antipruritic, can select Calamine Lotion, glucocorticoids Emulsion, cream for curing eczema etc. for use; The treatment of chronic phase is absorbed as the master with antipruritic, promotion corium inflammation, can select Pityrol ointment, cream for curing eczema, Eloson ointment, glucocorticoids ointment etc. for use; But not good enough according to its curative effect of the equal thoughts of clinical investigation, with the back recurrence is arranged more, can not cure fully; Patient has stronger dependency to medicine; Very easily recurrence after the drug withdrawal, its reason be since in this type medicine all more or less meeting contain the hormones composition, the glucocorticoid external can reduce capillary permeability; Minimizing is oozed out, and antiinflammatory and itching relieving effect are arranged.But the external glucocorticoid can only the short-term medication, and strict restriction consumption, and long-term external glucocorticoid can cause local skin atrophy, telangiectasis, acne and folliculitis etc., therefore, and the unsuitable long-term prescription of face and baby.Long-term a large amount of external glucocorticoid also can cause the general untoward reaction.Therefore the recurrence of the course of disease is unsurmountable problem, also is the critical problem that this disease of eczema heals than refractory.For chronic eczema, the past often helps with compound recipe pine tar ointment or coal tar preparation, because of curative effect limited, and easy pollution clothes, also few using.Some the court's preparations of each hospital, like preparations such as zinc oils, the problems referred to above still fail thoroughly to solve.It is investigated that new result sees, the Chinese medicine for outer use that really is used at present to treat eczema is few, and Cortex Phellodendri ointment, dermatitis curative ointment are only arranged; It is less that the two is used for clinical routine number, do not establish matched group, also do not make toxicological test; Only in institute, do the clinic trial stage, also do not declare problem by the new drug requirement.Thus, the external preparation that does not have treatment by Chinese herbs eczema in the market.
Because the eczema morbidity extensively, annual human and material resources, the financial resources that drop into of country are quite a lot of.And mosquito bite also is an inducement that causes eczema.The mosquito-repellent water product category is more in the market, but simultaneously again can itch stopping and diminish inflammation bacteriostatic mosquito-repellent water just few at mosquito repellent.Therefore this invention is considered in the development high-effective mosquito repelling liquid medicine, adds to have antiinflammatory, antipruritic, bacteriostatic natural Chinese medicines extract, and this sample product can be imitated anophelifuge by force; In a single day by mosquito bite, also have the effect of good anti-inflammatory anti-itch simultaneously, reduce to the worry that insecticide brings the mankind minimum; Guarantee that the mankind have good sleep; Not invaded and harassed by mosquito, operate as normal study, the dermatosis sickness rate that also will cause is thus reduced to minimum.
Product prescription of the present invention is the pure Chinese medicine for external application that does not contain hormone, and prescription is unique, has novelty.The advantages of nontoxic raw materials that these article are used, low price, with low cost, market prospect is wide, and the economic benefit and the social benefit of expection are considerable.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, a kind of high-effective mosquito repelling liquid medicine with mosquito-expelling and antipruritic is provided.The present invention is on the basis of repellant diethyltoluamide, in conjunction with Radix Glycyrrhizae extract (interior glycyrrhizic acid, enoxolone or their the physiologically acceptable salt of mainly containing), Radix Sophorae Flavescentis extract (including matrine 0%～90% or oxymatrine 0%～90% or their physiologically acceptable salt); Menthol 0%～90% or Borneolum Syntheticum 0%～90%; Plants essential oil 0.01%-0.5%; Utilize ethanol and water to be modulated into high-effective mosquito repelling liquid medicine; Have anophelifuge, antiinflammatory, itching-relieving efficacies.
The specific embodiment
Following embodiment can make those skilled in the art more fully understand the present invention, but does not limit the present invention in any way.
The active selection principle of drug target of the present invention is according to reaching because the disease characteristics of the eczema class skin injury that mosquito bite brings design drug regimen targetedly according to mosquito repelling.Mosquito-repellent is selected application market diethyltoluamide the most widely, and eczema is a kind of inflammatory skin disease of obviously oozing out tendency that has; Therefore we have selected to have Radix Glycyrrhizae extract (interior glycyrrhizic acid, enoxolone or their the physiologically acceptable salt of mainly containing), the Radix Sophorae Flavescentis extract (including matrine 0%～90% or oxymatrine 0%～90% or their physiologically acceptable salt) of very strong antiinflammatory action; Be equipped with menthol 0%～90% or Borneolum Syntheticum 0%～90% with itching-relieving action; Proportioning through plants essential oil strengthens antioxidation and regulates odor type simultaneously again at last.
Used effective ingredient and effective site have commercially availablely among the present invention, or can reach in accordance with known methods to describe in the document and prepare.
Aspect the preparation of mosquito-repellent water, this prescription mainly is to be mixed with the tincture of alcohol concentration from 30%-70% with ethanol and water.
Embodiment 1:
Prescription 1: contain diethyltoluamide 7%, Radix Glycyrrhizae extract 1%, Radix Sophorae Flavescentis extract 1%, menthol 0.5%, Flos Rosae Rugosae quintessence oil 0.05%, ethanol 30%, surplus is a deionized water.
Prescription 2: contain diethyltoluamide 2%, Radix Glycyrrhizae extract 2%, Radix Sophorae Flavescentis extract 2%, menthol 0.5%, rosemary ethereal oil 0.05%, Herba Lysimachiae foenum-graeci quintessence oil 0.1%; Ethanol 70%, surplus are deionized water.
Prescription 3: contain diethyltoluamide 5%, Radix Glycyrrhizae extract 0.5%, Radix Sophorae Flavescentis extract 0.5%, menthol 0.5%, Flos Rosae Rugosae quintessence oil 0.05%, ethanol 50%, surplus is a deionized water.
Prescription 4: contain diethyltoluamide 3%, glycyrrhizic acid 1%, matrine 1%, menthol 0.5%, tea tree ethereal oil 0.05%, ethanol 40%, surplus is a deionized water.
Prescription 5: contain diethyltoluamide 4%, enoxolone 2%, oxymatrine 1.5%, menthol 1%, Fructus Citri Limoniae quintessence oil 0.2%, ethanol 60%, surplus is a deionized water.
Prescription 6: contain diethyltoluamide 6%, enoxolone 0.5%, matrine 1%, Borneolum Syntheticum 2%, clove oil 0.2%, Eucalyptus quintessence oil 0.5%, ethanol 40%, surplus is a deionized water.
Embodiment two: The pharmacological results
1. anti-inflammatory activity
Test method: with 50 of mices, be divided into 5 groups at random, 10 every group; Be respectively negative control group (preparation that alcohol-water is processed), high-effective mosquito repelling liquid medicine low concentration group, concentration group in the high-effective mosquito repelling liquid medicine; High-effective mosquito repelling liquid medicine high concentration group, positive drug control group (compound recipe PINGYANPING RUANGAO).The medication group is respectively with basic, normal, high concentration high-effective mosquito repelling liquid medicine 0.5 gram, model group external-use substrate 0.5 gram, positive drug control group externally coated compound PINGYANPING RUANGAO 0.5 gram; Be applied in mice two auricular concha two sides, behind coating 1 hour, xylene 0.03ml dripped in mouse right ear shell two sides cause inflammation; After 2 hours; Mice dislocation is put to death, with diameter 6mm card punch respectively in the left and right sides ear symmetry locate to take off circular auricle, analytical balance is weighed. the weight difference of ears is the swelling degree.
Experimental result:
The mouse ear acute exudative inflammation that causes of the ointment xylol of three kinds of concentration all has the obvious suppression effect as a result.
2. antipruritic test
Experimental technique: with 50 of mices, be divided into 5 groups at random, 10 every group; Be respectively negative control group (preparation that alcohol-water is processed), high-effective mosquito repelling liquid medicine low concentration group, concentration group in the high-effective mosquito repelling liquid medicine; With basic, normal, high high-effective mosquito repelling liquid medicine ointment 0.5 gram, model group external-use substrate 0.5 gram, positive drug control group externally coated compound PINGYANPING RUANGAO 0.5 gram, elder generation is depilation 2cmx3cm size at the mouse carotid back respectively for high-effective mosquito repelling liquid medicine high concentration group, positive drug control group (compound recipe PINGYANPING RUANGAO) medication group; Administration respectively after 24 hours: outside model group depilation district, be coated with substrate 1 gram; Positive controls externally coated compound PINGYANPING RUANGAO 1 gram, outer respectively eczema ointment 1 gram that is coated with of medication group is behind the 30min; (4-AP is made into 0.5% solution with normal saline to give every mouse carotid back subcutaneous injection 4-APlmg/kg; Be diluted to 0.01% solution with normal saline before the experiment), observe in the 10min mice immediately and lick the body number of times (the mice appearance is turned one's head repeatedly and licked the behavior at back, both sides, promptly licks precursor reactant; Lick body continuously with mice and cause and minibreak occurs, do to lick body and once calculate).Require: licking body, must to lick its depilation district, back (medicine injection place) continuous more than 5 times, and just turning one's head or licking other position does not count; Minibreak requires: need walking, peak with heading, upright or smell shift action such as thing, do not consider time length; Turn one's head, lick hands repeatedly or wash one's face not very pause.
Experimental result:
The high-effective mosquito repelling liquid medicine that the result shows high, normal, basic three kinds of variable concentrations has tangible antagonism to the skin itching that the excessive release tissue amine of skin mastocyte due to the 4-AP causes.
Embodiment 3 mosquito-repellent water efficacy testings:
Examination worm: the female insect that Aedes albopictus (Aedes albopictus) was not sucked blood after sprouting wings in 4-5 days.
Detect according to " the agriculture chemical registration hygienic insecticide is indoor
Evaluating drug effect " (GB/T 17322.10-1998)
Testing conditions: 26 ± 1 ℃ of ambient temperatures, relative humidity 65 ± 5%.
Experimental result:
Different time is on average bitten frequency (inferior/2 minute)
Experiment conclusion:
High-effective mosquito repelling liquid medicine is estimated according to the GB/T17322.10-1998 in " evaluation of agriculture chemical registration hygienic insecticide indoor harmacological effect " the Aedes albopictus drug effect through laboratory; The repellent effect of prescription 1#, 3#, 5# and 6# meets the A grade standard, and the repellent effect of prescription 2# and 4# can be safeguarded 4-5 hour.
The test of embodiment 4 mosquito-repellent water toxicological tests:
(1) rat acute per os toxicity test:
Given the test agent: high-effective mosquito repelling liquid medicine 15g adding distil water is to the abundant mixing of 30mL, as given the test agent.
Experimental animal: regular grade SD rat, body weight 190-210g, each 10 of every group of male and female.
Test method: animal fasting overnight, divide male and female, by the body weight random packet, to press 10ml/kg body weight per os and irritate stomach, the symptom that occurs behind the stomach irritated in observation and record is death condition, in two weeks of Continuous Observation, calculates LD according to a maximal dose method
50.
Experimental result: do not have obvious poisoning symptom, do not see death.The animal gross anatomy is no abnormality seen also.LD
50See the following form.
Rat acute per os toxicity test
Record rat acute per os LD
50Male, female all greater than 5000mg/kg.
(2) rat acute toxicity on inhalation test:
Laboratory animal: SPF level Wistar kind rat, body weight 180～220g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., the quality certification number: SCXK-(capital) 2007-0001 0146686.Adapt to 3 days in experimental animal room, be in a good state of health.Experimental animal feeding environment: SPF level experimental animal room; The quality certification number: 20～25 ℃ of SYXK (Tianjin) 2008-0004. Animal House temperature ranges; Relative humidity scope 40～70%, feedstuff provides Feed Manufacturing credit number: SCXK-(capital) 2005-0007 by the assistant feed corporation,Ltd of Beijing section Australia.
Tried thing: high-effective mosquito repelling liquid medicine, light yellow transparent liquid, proportion are 980mg/ml, ph ≈ 6.5 (test paper method).
Test method
A. detect foundation: " agriculture chemical registration toxicology test method " GB15670-1995.
B. test method: according to related data, with once test method(s) test to greatest extent.8 of animal subjects, male and female half and half, dosage is 5000mg/m
3At volume is 600L (0.6m
3) the exposure in static total enclosure chamber cabinet in, will be tried thing and put in the evaporating dish, opening power test agent heated volatile starts mini-fan, is tried the gas that thing brings into play and evenly is full of in the toxicant exposure cabinet, rat is placed on is the 2h that once goes in the toxicant exposure cabinet and sucks exposure.Female, the great and mighty or powerful Mus in contamination back divides cage to feed, and observes animal poisoning symptom and death condition every day, observes for two weeks continuously.Gravimetric method is calculated concentration in the cabinet.
Result of the test
The no obvious poisoning symptom in animal subject contamination back does not have in the observation period dead (seeing the following form).
The female LD of high-effective mosquito repelling liquid medicine rat acute toxicity on inhalation
50＞5000mg/m
3, male LD
50＞5000mg/m
3
High-effective mosquito repelling liquid medicine rat acute toxicity on inhalation experimental result
Conclusion
According to acute toxicity on inhalation grade scale in Ministry of Agriculture's " agriculture chemical registration data regulation " (in December, 2007), originally tried the female LD of thing rat acute toxicity on inhalation
50＞5000mg/m
3, belong to little poison.
(3) rat acute percutaneous toxicity test:
Laboratory animal: SPF level Wistar kind rat, body weight 200～300g is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., the quality certification number: SCXK-(capital) 2007-0001 0146686.Adapt to 3 days in experimental animal room, be in a good state of health.Experimental animal feeding environment: SPF level experimental animal room; The quality certification number: 20～25 ℃ of SYXK (Tianjin) 2008-0004. Animal House temperature ranges; Relative humidity scope 40～70%, feedstuff provides Feed Manufacturing credit number: SCXK-(capital) 2005-0007 by the assistant feed corporation,Ltd of Beijing section Australia.
Tried thing: high-effective mosquito repelling liquid medicine, light yellow transparent liquid, proportion are 980mg/ml, ph ≈ 6.5 (test paper method).
Test method
A detects foundation: " agriculture chemical registration toxicology test method " GB15670-1995.
B test method: according to related data, with once test method(s) test to greatest extent.8 of animal subjects, male and female half and half, dosage is 5000mg/kgBW.Test trunk back depilation in preceding 24 hours, area 4 * 5cm
2Inspection skin does not have breakage after 24 hours, carries out skin contamination then.Tried thing and tested, shaken up before the sampling, divide in 20 minutes to apply for 3 times with stock solution.The contamination back covers with oilpaper, gauze, and rubber plaster is fixed.After 4 hours with soap water and the residual thing that tried of flushing with clean water.Observed and recorded is animal subject poisoning symptom and death toll in two weeks.
Result of the test
Do not see obvious poisoning symptom after the animal subject contamination, do not have dead in the observation period.
The female LD of high-effective mosquito repelling liquid medicine rat acute percutaneous toxicity
50＞5000mg/kgBW, male LD
50＞5000mg/kgBW..
High-effective mosquito repelling liquid medicine rat acute percutaneous toxicity
Conclusion
According to acute dermal toxicity grade scale in Ministry of Agriculture's " agriculture chemical registration data regulation " (in December, 2007), originally tried the female LD of thing rat acute percutaneous toxicity
50＞5000mg/kgBW belongs to little poison.
(4) irritation test
Select 3 of healthy rabbits, body weight is 2.5-3.0kg, and both sides, every rabbit back select a place to shave a mao 2.5cm
2, use the own control test method(s), respectively with high-effective mosquito repelling liquid medicine and each 0.5g of blank substrate; Be coated in equably and shave a mao position, 2 times/d, dermoreaction behind observation and record 24h and the 72h; Reactions such as that the result does not all have is rubescent, dermexanthesis, blister are explained this ointment nonirritant, external safety.
Claims (4)
1. a mosquito-repellent water is characterized in that comprising by weight percentage following component: N, N-n,N-diethyl meta-toluamide 3%, and glycyrrhizic acid 1%, matrine 1%, menthol 0.5%, tea tree ethereal oil 0.05%, ethanol 40%, surplus is a deionized water.
2. a mosquito-repellent water is characterized in that comprising by weight percentage following component: N, N-n,N-diethyl meta-toluamide 4%, enoxolone 2%, oxymatrine 1.5%, menthol 1%, Fructus Citri Limoniae quintessence oil 0.2%; Ethanol 60%, surplus are deionized water.
3. a mosquito-repellent water is characterized in that comprising by weight percentage following component: N, N-n,N-diethyl meta-toluamide 6%, and enoxolone 0.5%, matrine 1%, Borneolum Syntheticum 2%, clove oil 0.2%, Eucalyptus quintessence oil 0.5%, ethanol 40%, surplus is a deionized water.
4. claim 1 or 2 or 3 mosquito-repellent water are bitten and the application of antipruritic agent at the preparation mosquito repellent.
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| CN103735464A (en) * | 2014-01-15 | 2014-04-23 | 张一文 | Floral water for preventing mosquito bite |
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| CN104921988A (en) * | 2015-06-03 | 2015-09-23 | 刘强 | Mosquito-repelling liquid |
| CN105362351A (en) * | 2015-12-16 | 2016-03-02 | 成都昊健生物科技有限责任公司 | Medicine composition for treating cutaneous pruritus disease and application thereof |
| CN107049833A (en) * | 2016-12-27 | 2017-08-18 | 广东绿环生物科技股份有限公司 | A kind of tea tree ethereal oil mosquito-driving liquid and preparation method thereof |
| CN107691494A (en) * | 2017-11-08 | 2018-02-16 | 李倩 | A kind of preparation method of children's mosquito repellent incense liquid of long-acting mosquito-driving |
| CN108096564A (en) * | 2017-12-29 | 2018-06-01 | 塔里木大学 | A kind of externally applied drug for preventing livestock and poultry vermin |
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