CN101822631B - Combination drug for repelling animals and insects - Google Patents
Combination drug for repelling animals and insects Download PDFInfo
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- CN101822631B CN101822631B CN 201010182822 CN201010182822A CN101822631B CN 101822631 B CN101822631 B CN 101822631B CN 201010182822 CN201010182822 CN 201010182822 CN 201010182822 A CN201010182822 A CN 201010182822A CN 101822631 B CN101822631 B CN 101822631B
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- insects
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- repelling animals
- plant extract
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- 241000238631 Hexapoda Species 0.000 title claims abstract description 22
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- 230000001846 repelling effect Effects 0.000 title claims abstract description 22
- 229940000425 combination drug Drugs 0.000 title claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 22
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000419 plant extract Substances 0.000 claims abstract description 16
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 14
- 239000011707 mineral Substances 0.000 claims abstract description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 14
- 229940079593 drug Drugs 0.000 claims abstract description 13
- 241000123611 Dipterocarpaceae Species 0.000 claims abstract description 9
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960001826 dimethylphthalate Drugs 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
- 239000002671 adjuvant Substances 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 8
- 229910052957 realgar Inorganic materials 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 239000011593 sulfur Substances 0.000 claims description 8
- 230000002421 anti-septic effect Effects 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 4
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 claims description 4
- 239000000341 volatile oil Substances 0.000 claims description 4
- 239000000080 wetting agent Substances 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000006184 cosolvent Substances 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- VZRKEAFHFMSHCD-UHFFFAOYSA-N Ethyl 3-(N-butylacetamido)propionate Chemical compound CCCCN(C(C)=O)CCC(=O)OCC VZRKEAFHFMSHCD-UHFFFAOYSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- -1 antiseptic Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 229950008882 polysorbate Drugs 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 208000035473 Communicable disease Diseases 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 3
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 abstract 1
- 240000002234 Allium sativum Species 0.000 abstract 1
- 244000166675 Cymbopogon nardus Species 0.000 abstract 1
- 235000018791 Cymbopogon nardus Nutrition 0.000 abstract 1
- 240000005636 Dryobalanops aromatica Species 0.000 abstract 1
- 244000018716 Impatiens biflora Species 0.000 abstract 1
- 244000046052 Phaseolus vulgaris Species 0.000 abstract 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 abstract 1
- 244000178231 Rosmarinus officinalis Species 0.000 abstract 1
- 241000246091 Thermopsis Species 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 230000000857 drug effect Effects 0.000 abstract 1
- 235000004611 garlic Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 230000002940 repellent Effects 0.000 description 8
- 239000005871 repellent Substances 0.000 description 8
- 241000255925 Diptera Species 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 241000238659 Blatta Species 0.000 description 3
- 241001251068 Formica fusca Species 0.000 description 3
- 241000237903 Hirudo Species 0.000 description 3
- 241000238661 Periplaneta Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000243684 Lumbricus Species 0.000 description 2
- 241000131808 Scolopendra Species 0.000 description 2
- 241000522620 Scorpio Species 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000009490 scorpio Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000269417 Bufo Species 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 240000001307 Myosotis scorpioides Species 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
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- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Abstract
The invention discloses a combination drug for repelling animals and insects, which comprises the following components by mass content: 10% to 50% of plant extract, 5% to 40% of mineral drugs, 1% to 40% of dimethyl phthalate, 10% to 60% of excipient auxiliary materials and a proper amount of water, wherein the plant extract is extracted from one or more than one of garlic, citronella, rhizoma acori graminei, bean thermopsis, folium artemisiae argyi, balsamine, rosemary, cinnamomum camphora and dipterocarpaceae. The drug prepared according to the technical scheme of the invention is capable of repelling various animals and insects, has the advantages of strong effect and efficacy and long drug effect, and achieves the curative effect to a certain extent, particularly the effect of effectively preventing the infectious diseases spread through skin from being spread; besides, the combination drug prevents the skin from feeing oily after application, causes no contamination to clothes and is easily cleaned after administration; and moreover, the combination drug can further achieve the effects of moistening and moisturizing.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, relate to a kind of composition of medicine that is used for repelling animals and insects specifically.
Background technology
Under special environment condition (like jungle such as moist or damp and hot); Various beastly worms such as Serpentis, Aranea, Hirudo, Scolopendra, Formica fusca, mosquito, Blatta seu periplaneta, Cicadae etc. are usually created disturbances to what people's life formed, are that people camp always, tourism, are difficult to the thorny problem avoided when officers and men instruct.After beastly insect bite evil, also can cause the propagation of infectious diseases such as poisoning, skin injury and malaria.Prevent beastly worm to create disturbances to, injure and then seem important further.The medicine of at present commercially available mosquito dispersing is divided into two types, and one type is chemical synthesis preparation, and its action effect is fast, but there is side effect in human body skin, even causes the damage of skin, and chemicals can cause the more weak personnel's of part body constitution anaphylaxis usually; Another kind of be essence class medicine, mainly be to process by Chinese herbal medicine extract, the kind of beastly worm medicine is single, effectiveness is relatively poor, efficiency time is not long but this type of exterior-applied article drives.Therefore develop easy to use, carry, safety, long lasting beastly worm repellant, have very important civilian value and military significance.
The object of the invention is studied a kind of compound repellant exactly and is suitable for the scale equipment, can satisfy army and be in field operations, training medical security under the aforementioned special environment, also can satisfy the needs of the daily tourism repelling animals and insects of camping of people.
Summary of the invention
The objective of the invention is in order to solve the defective of above-mentioned existing anthelmintic mosquito medicine; A kind of compound repellant compositions is provided; It has overcome, and existing repelling animals and insects product range of application is single, short to skin irritation infringement, action effective, repellent is renderd a service not strong problem; And it have the multiple beastly worm of repellent, advantage strong, longer duration is renderd a service in effect, and has therapeutical effect to a certain degree, the spreading of the infectious disease that can prevent effectively to propagate through the skin approach; Its characteristics can abbreviate " the repellent one is prevented and treated one, relied mainly on prevention " as.In addition, skin does not have greasy feeling, pollution clothes not after the obliterating, with after be easy to clean, and also can play effect moist, that preserve moisture to skin.
The technical scheme of the present invention that realizes above-mentioned purpose is that a kind of combination drug for repelling animals and insects comprises plant extract; Mineral drug, dimethyl phthalate (BAAPE) and excipient adjuvant, above-mentioned each composition mass content is respectively; The content of plant extract is 10～50%; The content of mineral drug is 5～40%, and the content of dimethyl phthalate is 1～40%, and figuration adjuvant content is 10～60%; And an amount of water, above-mentioned plant extract be from Bulbus Allii, Herba Cymbopogonis Citrari, Rhizoma Acori Graminei, Serpentis exterminate a family, Folium Artemisiae Argyi, Impatientis, Herba Rosmarini Officinalis, Cortex cinnamomi camphorae, Dipterocarpaceae a kind of or extract several form.
Above-mentioned mineral drug is the two a mixture of Realgar or sulfur or its.
Above-mentioned excipient adjuvant is a kind of or several mixture in gel-type vehicle, pH regulator agent, wetting agent, antiseptic, stabilizing agent, cosolvent, solubilizing agent, the emulsifying agent.Wherein, gel-type vehicle is that a kind of in silicone, hydroxypropyl cellulose, Polysorbate, propylene glycol, Polyethylene Glycol, octadecanol, carbomer, gelatin, the tragakanta or several mix; Wetting agent is glycerol or polyhydric alcohol or its both mixture; Regulator is citric acid or triethanolamine; Antiseptic is a nipalgin series.
The method of above-mentioned plant extract is that Bulbus Allii, Herba Cymbopogonis Citrari, Rhizoma Acori Graminei, Serpentis are exterminated a family, Folium Artemisiae Argyi, Impatientis, Herba Rosmarini Officinalis, adopt supercritical carbon dioxide extraction or volatile oil extractor method or physics extraction in Cortex cinnamomi camphorae, Dipterocarpaceae a kind of or several.
Composition of medicine of the present invention can be made gel-type preparation or solution type preparation.
The advantage that the present invention has forms through extracting for (1) this pharmaceutical composition is a kinds of traditional Chinese medicines, can common beastly worm etc. has multiple-effect, long-acting repellent action; (2) these article have the functional characteristics of " the repellent one is prevented and treated one, relied mainly on prevention "; (3) these article are without any side effects to human body.
The specific embodiment
With gel-type and solution-type technical scheme of the present invention is described below respectively below in conjunction with concrete embodiment:
(1) repelling animals and insects compositions (gel-type)
Plant extract: get Bulbus Allii 10 respectively by mass ratio, Herba Cymbopogonis Citrari 5, Rhizoma Acori Graminei 5, Serpentis exterminates a family 50; Folium Artemisiae Argyi 10, Impatientis 5, Herba Rosmarini Officinalis 5, Cortex cinnamomi camphorae 5, Dipterocarpaceae 5 mix; Said medicine gets the volatile oil part behind supercritical carbon dioxide extraction, preparation promptly gets required plant extract.
Mineral drug micropowder: utilize the two mixture of Realgar or sulfur or its to prepare the mineral powder, in the present embodiment, with 6: 4 by mass percentage mixed after Realgar, the sulfur micronizing.
Excipient adjuvant (substrate): hydroxypropyl cellulose 1.5%, Acritamer 940 0.5%, propylene glycol 20%, methyl hydroxybenzoate 0.03%, citric acid transfer to pH 7 in right amount, and deionized water is prepared from right amount.
With above-mentioned plant extract, mineral drug and dimethyl phthalate respectively with behind 1: 1 ratio of mass ratio and excipient adjuvant (substrate) mix homogeneously; In this three partially mixed thing, add citric acid adjust pH to 7 more respectively; Get respectively again this three part by mass percentage 60%, 30%, 10% mixing fully stir, the cooling, fill get final product gel-type combination drug for repelling animals and insects preparation.
(2) repelling animals and insects compositions (solution-type)
Plant extract: take by weighing Bulbus Allii 10 respectively by mass ratio, Herba Cymbopogonis Citrari 10, Rhizoma Acori Graminei 10; Serpentis exterminates a family 40, Folium Artemisiae Argyi 10, Impatientis 10; Herba Rosmarini Officinalis 5, Cortex cinnamomi camphorae 2.5, Dipterocarpaceae 2.5 mix the back through behind the supercritical carbon dioxide extraction, get the volatile oil part, prepared plant extracts.
The mineral drug micropowder: with pressing Realgar after Realgar, the sulfur micronizing: 7: 3 quality of sulfur is prepared into mineral medicated powder than mix homogeneously.
Excipient adjuvant (substrate): Polyethylene Glycol, triethanolamine, glycerol, ethanol, deionization were pressed mass ratio 5: 2: 1: mix back prepare substrate at 1: 1.
With above-mentioned plant extract, mineral drug and dimethyl phthalate respectively with behind 1: 1 ratio of mass ratio and excipient adjuvant (substrate) mix homogeneously; In this three partially mixed thing, add citric acid adjust pH to 7 more respectively; Get respectively again this three part by mass percentage 70%, 20%, 10% mixing fully stir, the cooling, fill get final product solution-type combination drug for repelling animals and insects preparation.
The above-mentioned gel-type or the solution-type combination drug for repelling animals and insects preparation of technical scheme of the present invention preparation of utilizing is applied on the human body skin, in order to repelling animals and insects, exempt from beastly worm and create disturbances to, injure.The effect of each component is: (1) Rhizoma Acori Graminei, Bulbus Allii, Herba Cymbopogonis Citrari, Folium Artemisiae Argyi, Cortex cinnamomi camphorae, Herba Rosmarini Officinalis, Dipterocarpaceae, Impatientis: beastly worms such as repellent mosquito, Blatta seu periplaneta, caterpillar, Formica fusca, fly, Hirudo, louse, flea; (2) Serpentis exterminate a family, sulfur, Realgar: beastly worms such as repellent Serpentis, Scolopendra, Aranea, Bufo siccus, thousand-legger (Prospirolboli joannsi), Scorpio, Lumbricus, Serpentis, Scorpio, Hirudo, Lumbricus; (3) dimethyl phthalate: beastly worms such as repellent fly, louse, Formica fusca, mosquito, Blatta seu periplaneta, Cicadae; (3) hydroxypropyl cellulose: dispersant, thickening agent, film former; (4) carbomer: thickening agent, suspending agent, emulsifying agent; (5) propylene glycol: cosolvent; (6) methyl hydroxybenzoate: antiseptic; (7) citric acid: pH value regulator, antiseptic.
Certainly, the present invention also can adopt other excipient to be prepared into other dosage forms.
Technique scheme has only embodied the optimal technical scheme of technical scheme of the present invention, the technical staff in present technique field to some part wherein some changes that possibly make all embodied principle of the present invention, belong within protection scope of the present invention.
Claims (8)
1. combination drug for repelling animals and insects; Comprise the plant extract medicine; Mineral drug, dimethyl phthalate (BAAPE) and excipient adjuvant is characterized in that; Above-mentioned each composition mass content is respectively; The content of plant extract is 10～50%, and the content of mineral drug is 5～40%, and the content of dimethyl phthalate is 1～40%; Figuration adjuvant content is 10～60% and suitable quantity of water; Above-mentioned plant extract be by Bulbus Allii, Herba Cymbopogonis Citrari, Rhizoma Acori Graminei, Serpentis exterminate a family, Folium Artemisiae Argyi, Impatientis, Herba Rosmarini Officinalis, Cortex cinnamomi camphorae, Dipterocarpaceae be according to 10: 5: 5: 50: 10: 5: 5: 5: 5 ratio, mineral drug be Realgar and sulfur according to 6: 4 ratio or Bulbus Allii, Herba Cymbopogonis Citrari, Rhizoma Acori Graminei, Serpentis exterminate a family, Folium Artemisiae Argyi, Impatientis, Herba Rosmarini Officinalis, Cortex cinnamomi camphorae, Dipterocarpaceae be according to 10: 10: 10: 40: 10: 10: 5: 2.5: 2.5 ratio, mineral drug Realgar and sulfur extracted mixed mixture according to 7: 3 ratio.
2. according to the said combination drug for repelling animals and insects of claim 1, it is characterized in that the excipient adjuvant is a kind of or several mixture in gel-type vehicle, pH regulator agent, wetting agent, antiseptic, stabilizing agent, cosolvent, solubilizing agent, the emulsifying agent.
3. according to the said combination drug for repelling animals and insects of claim 2; It is characterized in that the gel-type vehicle in the excipient adjuvant is that a kind of in silicone, hydroxypropyl cellulose, Polysorbate, propylene glycol, Polyethylene Glycol, octadecanol, carbomer, gelatin, the tragakanta or several mix.
4. according to the said combination drug for repelling animals and insects of claim 2, it is characterized in that the wetting agent in the excipient adjuvant is the two a mixture of glycerol or polyhydric alcohol or its.
5. according to the said combination drug for repelling animals and insects of claim 2, it is characterized in that the pH value regulator in the excipient adjuvant is citric acid or triethanolamine.
6. according to the said combination drug for repelling animals and insects of claim 2, it is characterized in that the antiseptic in the excipient adjuvant is a nipalgin series, and its mass percent is 0.05～2%.
7. according to the said combination drug for repelling animals and insects of claim 1, it is characterized in that this composition of medicine can be made gel-type preparation or solution type preparation.
8. according to the said combination drug for repelling animals and insects of claim 1; It is characterized in that, plant extract with Bulbus Allii, Herba Cymbopogonis Citrari, Rhizoma Acori Graminei, Serpentis exterminate a family, Folium Artemisiae Argyi, Impatientis, Herba Rosmarini Officinalis, Cortex cinnamomi camphorae, Dipterocarpaceae adopt supercritical carbon dioxide extraction or volatile oil extractor method or physics extraction to extract and obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010182822 CN101822631B (en) | 2010-05-26 | 2010-05-26 | Combination drug for repelling animals and insects |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010182822 CN101822631B (en) | 2010-05-26 | 2010-05-26 | Combination drug for repelling animals and insects |
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| CN101822631A CN101822631A (en) | 2010-09-08 |
| CN101822631B true CN101822631B (en) | 2012-04-18 |
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| CN 201010182822 Expired - Fee Related CN101822631B (en) | 2010-05-26 | 2010-05-26 | Combination drug for repelling animals and insects |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102551580B (en) * | 2012-01-12 | 2014-09-10 | 杭州国光旅游用品有限公司 | Multifunctional moist towelette |
| CN102630711B (en) * | 2012-03-29 | 2014-02-12 | 王绍坤 | Wild protection liquid and preparation method thereof |
| CN105342019A (en) * | 2015-12-24 | 2016-02-24 | 中国人民解放军总后勤部军需装备研究所 | Sock capable of preventing beggarweed |
| CN106388666A (en) * | 2016-08-30 | 2017-02-15 | 杭州国光旅游用品有限公司 | Degreasing wet tissue and preparation method thereof |
| CN106724286A (en) * | 2016-11-18 | 2017-05-31 | 广西大学 | A kind of chair for fishing |
| CN106410681B (en) * | 2016-12-21 | 2018-04-20 | 国网内蒙古东部电力有限公司检修分公司 | Electric power line pole tower peculiar smell hinders snake device |
| CN110756026A (en) * | 2019-11-05 | 2020-02-07 | 深圳市芬多精纳米生物科技有限公司 | Nano fendorin composition for odor removal and preparation method thereof |
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| CN1215855C (en) * | 2002-07-05 | 2005-08-24 | 唐笙富 | Externally applied medicine for stopping itching, relieving pain and eliminating swelling |
| CN1259030C (en) * | 2003-05-13 | 2006-06-14 | 上海家化联合股份有限公司 | Mosquito-repellent toilet water |
| CN100544703C (en) * | 2006-05-17 | 2009-09-30 | 王明镜 | Mosquito repellent composition |
| CN101843566B (en) * | 2010-03-31 | 2012-10-17 | 北京日蒙生物科技有限公司 | Mosquito repellent and preparation method thereof |
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