CN101843566B - Mosquito repellent and preparation method thereof - Google Patents
Mosquito repellent and preparation method thereof Download PDFInfo
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- CN101843566B CN101843566B CN201010139574A CN201010139574A CN101843566B CN 101843566 B CN101843566 B CN 101843566B CN 201010139574 A CN201010139574 A CN 201010139574A CN 201010139574 A CN201010139574 A CN 201010139574A CN 101843566 B CN101843566 B CN 101843566B
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Abstract
The invention relates to a mosquito repellent and a preparation method thereof, belonging to the technical field of daily chemical engineering. The mosquito repellent is prepared from the following components: 25-40% of dimethyl phthalate, 0.5-1.2% of Carbomer 940, 10-15% of polyethylene glycol 400, 2-10% of propylene glycol, 2-10% of 95% ethanol, 5-10% of polyethylene glycol 6000, 0.5-2% of triethanolamine and balance of de-ionized water. The invention decreases the alcohol concentration, increases the dimethyl phthalate content, enables the skin to feel clean and cool in a similar way after smearing the gel type mosquito repellent under the condition of enhancing the effect by adjusting the solvent components, and achieves certain moisture retention and moistening effects on the skin after smearing the gel type mosquito repellent by the mutual cooperation of the propylene glycol and the polyethylene glycols 400 and 6000, thereby being applicable to personnel who perform long-term field operation.
Description
Technical field
The present invention relates to the daily chemical product field, particularly relate to a kind of mosquito-repellent and method for preparing.
Background technology
Anophelifuge is a high-tech mosquito repellent product of new generation, has derived multiple dosage form in the market.As, mosquito-repellent perfume, mosquito-repellent water, anophelifuge balsam, mosquito-dispelling cream or the like.Anophelifuge has easy to use, does not receive the characteristics of the restriction of time and service condition, directly be applied on the exposed skin and can play repelling effect, as essential balm, mosquito do not sting, mosquito-dispelling cream etc.Be particularly suitable for camping, field work personnel such as army, oil field, geology, forestry and the night attendant of factory use.
It is multiple that anophelifuge effective ingredient on the domestic and international market has pyrethrin mosquitofugal oil, dimethyl phthalate (BAAPE), anophelifuge ketone, Rutgers 612, anophelifuge amine (DETA or title DEET) etc. at present; And can reach long-acting mosquito-driving and toxic and side effects less mainly contain two kinds, anophelifuge amine and up-to-date succedaneum dimethyl phthalate.
Patent of invention " mosquito-repellent " (application number: 92114094.0) make the gel dosage form to dimethyl phthalate; Make and feel salubrious after smearing; But, make the skin after smearing lack moisture feeling because the nice and cool property after excessively stressing to smear has added heavy dose of ethanol; A large amount of addings of ethanol make the gel dosage form at high temperature thinning simultaneously.
Summary of the invention
To the deficiency in above-mentioned field, the inventor provides a kind of mosquito-repellent, can not only mosquito repellent, and can also play skin care after smearing, the effect of protection skin is particularly suitable for open-air effect personnel and uses.
Mosquito-repellent, form by following component:
Dimethyl phthalate 25%-40%
Acritamer 940 0.5%-1.2%
PEG400 10%-15%
Propylene glycol 2%-10%
95% ethanol 2%-10%
Polyethylene glycol 6000 5%-10%
Triethanolamine 0.5-2%
All the other are deionized water.
Polyvinyl pyrrolidone/hexadecene the copolymer that also contains 5%-10% in the said component.
Preferably: dimethyl phthalate 25%
Acritamer 940 1%
PEG400 12%
Propylene glycol 5%
95% ethanol 5%
Polyethylene glycol 6000 6%
Polyvinyl pyrrolidone/hexadecene copolymer 6%
Triethanolamine 1.1%
All the other are deionized water.
The method for preparing of above-mentioned mosquito-repellent; Comprise the steps: the preparation of (1) gel-type vehicle: in propylene glycol, slowly add Acritamer 940 simultaneously in stirring; The deionized water that adds the 80%-90% metering then; Heated and stirred to Acritamer 940 swelling is complete, is chilled to 25 ℃-35 ℃ and adds 95% ethanol down, regulates pH 5.0～7.0 with triethanolamine; (2) preparation of band medicine mixed liquor: the water with 10%-20% under the room temperature is made into aqueous solution with polyethylene glycol 6000, adds PEG400 and stirs, and adds dimethyl phthalate and polyvinyl pyrrolidone/hexadecene copolymer, stirs to such an extent that be with the medicine mixed liquor; (3) the band medicine mixed liquor that (2) is obtained adds in the gel-type vehicle of (1), adds water to full dose, and stirring gets final product.
The present invention has reduced the concentration of ethanol; Improve the consumption of dimethyl phthalate, through the composition of adjustment solvent, made gel-type mosquito-repellent of the present invention under the enhanced situation of effect simultaneously; It is same salubrious pleasantly cool to smear the back dermal sensation; Through propylene glycol, PEG400,6000 cooperatively interact, smearing the back has certain water conservation to moisten effect to skin, is applicable to long-term field work personnel simultaneously.
The present invention is dissolved in ethanol in the gel in the preparation process, and has used a large amount of high molecular alcohols materials to disperse dimethyl phthalate, makes the gel dosage form at high temperature keep original gel state, and is not thinning.
Adding in the component of the present invention has slow releasing agent polyvinyl pyrrolidone/hexadecene copolymer, can make mosquito-repelling effect of the present invention keep more lasting, holds and imitates more than 10 hours.
Description of drawings
Fig. 1 mosquito-repellent of the present invention preparation technology's flow chart
The specific embodiment
[prescription]
Raw material and supplementary product consumption
Dimethyl phthalate 10000g
Acritamer 940 400g
PEG400 4800g
Propylene glycol 2000g
95% ethanol 2000g
Polyethylene glycol 6000 2400g
Polyvinyl pyrrolidone/hexadecene copolymer 2400g
Triethanolamine 440g
Deionized water 15560g
Process 1000
[effect of supplementary material in prescription]
Dimethyl phthalate---repellant
Acritamer 940---thickening agent
PEG400---solubilizing agent
Propylene glycol---wetting agent
95% ethanol---skin sense regulator
Polyethylene glycol 6000---film former
Polyvinyl pyrrolidone/hexadecene copolymer---slow releasing agent
Triethanolamine---nertralizer
Deionized water---solvent
[method for making]
1. the preparation of gel-type vehicle:
In propylene glycol, slowly add Acritamer 940 simultaneously in stirring, add the 13000g deionized water then, be stirred to evenly; Be warming up to 50 ℃, it is complete to the Acritamer 940 swelling to heat while stirring, and stops heating; When being cooled to below 30 ℃, add 95% ethanol, stir; Regulate pH 5.0～7.0 with triethanolamine, make gel-type vehicle.
2. the preparation of band medicine mixed liquor:
Polyethylene glycol 6000 is mixed with 50% aqueous solution, joins in the PEG400, then, add dimethyl phthalate and polyvinyl pyrrolidone/hexadecene copolymer successively, stir, must be with the medicine mixed liquor.
3. the preparation of long-acting mosquito-driving gel:
Under agitation, join in 12, add deionized water, stir, promptly get the long-acting mosquito-driving gel to 40000g.Its preparation technology's flow chart is seen shown in Figure 1.
One, laboratory repellent experiment effect is estimated
The attack test:
Growing * put into 600 examination worms in the mosquito cage of height * wide 20 * 20 * 30cm of being, male and female half and half, testing crew exposes 4cm * 4cm skin at arm, and remainder is tight to be covered.Arm stretched into place certain hour in the mosquito cage (Aedes albopictus is 3min; Culex pipiens pallens is 5min), Aedes albopictus stops falling more than 30 in the examination borer population that record comes to stop falling, 3min; Culex pipiens pallens stops falling more than 20 in 5 minutes, judges that this testing crew and this cage mosquito can be used for repellency test.
Repellency test:
Select the qualified testing crew of attack, the skin area of the 5cm * 5cm that on its both hands arm, respectively draws, wherein an arm is the attack experimental control, the another hands is pressed 1.5mg/cm
2Dosage evenly smear repellant to be measured, expose 4cm * 4cm skin wherein.Smear 2h after the repellant, arm is stretched in the qualified mosquito cage of attack (when attack is lower than requirement, stop the test of human body coating; This invalidate the test); Each 3 minutes (Aedes albopictus) or 5 minutes (culex pipiens pallens), observation has or not mosquito to come to suck blood, and per hour tests once later on; Observe the situation of biting of mosquito, 1 observation has 2 mosquito bite or accumulative total 3 above mosquito bite to be arranged for losing efficacy.
The result shows that the effective repellent of mosquito-repellent laboratory Aedes albopictus was for up to 10.2 hours, and culex pipiens pallens is 13.5 hours.
Two, safety evaluatio
(1) acute dermal toxicity test: according to acute oral toxicity grade scale in " the agriculture chemical registration data regulation " of Ministry of Agriculture's promulgation in 2007, these article acute dermal toxicity belongs to little poison.
(2) skin allergic reaction (sensitization) test: according to " agriculture chemical registration toxicology test method " GB 15670-1995 sensitization rate strength grading standard, long-acting mosquito-driving gel skin allergic reaction (sensitization) intensity is the I level, belongs to weak sensitizer.
(3) eye irritant test: stimulate grade scale according to " agriculture chemical registration toxicology test method " GB 15670-1995 eye, these article eye irritant test belongs to nonirritant.
(4) acute oral toxicity: according to acute oral toxicity grade scale in " the agriculture chemical registration data regulation " of Ministry of Agriculture's promulgation in 2007, these article acute oral toxicity belongs to little poison.
(5) acute skin irritation test: according to " agriculture chemical registration toxicology test method " GB 15670-1995 acute skin irritation test grade scale, these article acute skin irritation test belongs to nonirritant.
Three, stability test
According to the relevant new drug estimation of stability index of country, the quality of mosquito-repellent the test of anti-height (low) temperature, strong illumination test have been carried out; Accelerated stability test and long-term stable experiment; The result shows this controllable product quality, and stable in properties confirms that tentatively its effect duration is 36 months.
In sum, prove that mosquito-repellent is safe in utilization, effect is remarkable, steady quality, and at high temperature the thinning phenomenon of gel-free meets field work guarantor person's medicine requirement.
Claims (2)
1. mosquito-repellent, form by following component:
All the other are deionized water.
2. the method for preparing of the described mosquito-repellent of claim 1; Comprise the steps: the preparation of (1) gel-type vehicle: in propylene glycol, slowly add Acritamer 940 simultaneously in stirring; The deionized water that adds the 80%-90% metering then; Heated and stirred to Acritamer 940 swelling is complete, is chilled to 25 ℃-35 ℃ and adds 95% ethanol down, regulates pH 5.0～7.0 with triethanolamine; (2) preparation of band medicine mixed liquor: the water with 10%-20% under the room temperature is made into aqueous solution with polyethylene glycol 6000, adds PEG400 and stirs, and adds dimethyl phthalate and polyvinyl pyrrolidone/hexadecene copolymer, stirs to such an extent that be with the medicine mixed liquor; (3) the band medicine mixed liquor that (2) is obtained adds in the gel-type vehicle of (1), adds water to full dose, and stirring gets final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010139574A CN101843566B (en) | 2010-03-31 | 2010-03-31 | Mosquito repellent and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010139574A CN101843566B (en) | 2010-03-31 | 2010-03-31 | Mosquito repellent and preparation method thereof |
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| CN101843566A CN101843566A (en) | 2010-09-29 |
| CN101843566B true CN101843566B (en) | 2012-10-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103262839A (en) * | 2013-05-31 | 2013-08-28 | 广州立白企业集团有限公司 | Mosquito repelling gel composition with natural plant essential oil |
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| CN101822631B (en) * | 2010-05-26 | 2012-04-18 | 中国人民解放军第三○二医院 | Combination drug for repelling animals and insects |
| CN102949297A (en) * | 2012-06-14 | 2013-03-06 | 江西农业大学 | Mosquito repellent gel and preparation method thereof |
| CN102846493B (en) * | 2012-08-13 | 2014-12-17 | 北京绿叶世纪日化用品有限公司 | Long-acting repellent liquid and preparation method thereof |
| CN105920091B (en) * | 2016-04-26 | 2020-04-21 | 中国农业科学院兰州畜牧与兽药研究所 | Yak cattle hide fly repellent as well as preparation method and application thereof |
| CN106035415A (en) * | 2016-06-15 | 2016-10-26 | 安徽菲扬农业科技有限公司 | Pest repellent and preparation method thereof |
| CN106135317A (en) * | 2016-06-30 | 2016-11-23 | 安徽金培因科技有限公司 | A kind of insects repellant and preparation method thereof |
| CN109248100B (en) * | 2018-10-25 | 2021-08-06 | 湖南雪天精细化工股份有限公司 | Mosquito repellent liquid and preparation method thereof |
| CN110547292A (en) * | 2019-09-06 | 2019-12-10 | 上海中华药业有限公司 | Mosquito-repellent gel and preparation method thereof |
| CN110897917B (en) * | 2019-12-31 | 2023-09-15 | 河南安进生物技术股份有限公司 | Long-acting mosquito repellent of mosquito repellent ester and preparation method thereof |
| CN114831115A (en) * | 2021-02-02 | 2022-08-02 | 浙江澳岚丁生物科技有限公司 | Antimalarial, mosquito-repellent and bacteriostatic composition and preparation method thereof |
| CN113476316A (en) * | 2021-06-02 | 2021-10-08 | 润本生物技术股份有限公司 | High-safety mosquito repelling gel and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103262839A (en) * | 2013-05-31 | 2013-08-28 | 广州立白企业集团有限公司 | Mosquito repelling gel composition with natural plant essential oil |
| CN103262839B (en) * | 2013-05-31 | 2014-12-03 | 广州立白企业集团有限公司 | Mosquito repelling gel composition with natural plant essential oil |
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| CN101843566A (en) | 2010-09-29 |
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Owner name: BEIJING RIMENG BIOLOGIC TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: BEIJING RURIZHONGTIAN TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20111012 |
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