CN109498735A - A kind of drug and preparation method thereof for treating bite by mosquitos - Google Patents
A kind of drug and preparation method thereof for treating bite by mosquitos Download PDFInfo
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- CN109498735A CN109498735A CN201910043568.4A CN201910043568A CN109498735A CN 109498735 A CN109498735 A CN 109498735A CN 201910043568 A CN201910043568 A CN 201910043568A CN 109498735 A CN109498735 A CN 109498735A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- Natural Medicines & Medicinal Plants (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The drug for the treatment of bite by mosquitos provided by the present invention, the raw material that it is made includes the substance of following mass parts: 350~500 parts of fresh purslane, 50~100 parts of fresh mint leaf, 100~200 parts of fresh balsamine leaf, 10~20 parts of wild chrysanthemum and 20 parts of Paris polyphylla.The preparation method is as follows: 1) water is added after cleaning the fresh purslane of recipe quantity, fresh mint leaf, fresh balsamine leaf, wild chrysanthemum, after smashing broken wall with pulverizer, saved in 0-4 DEG C of standing, filtering takes supernatant, adds water to be settled to 2000 parts, for use；2) it by the wild chrysanthemum of recipe quantity and Paris polyphylla cold water soak, then adds water to cook twice, merges decoction liquor, add water to be settled to 500 parts, for use；3) supernatant that step 1) obtains is obtained decoction liquor with step 2) to mix, sodium carbonate is then added into gained mixed liquor, adjust pH value to 8.5-9；4) sodium benzoate, medicinal alcohol is added in the mixed liquor then prepared to step 3), is uniformly mixed；5) sterilizing, it is filling, vacuum packaging to get.To can be used for treating, various mosquitoes (such as mosquito, hornet, honeybee) bite the drug and poisonous insect (such as centipede) is bitten, significant effect.
Description
Technical field
The invention belongs to drug fields, and in particular to a kind of drug and preparation method thereof for treating bite by mosquitos.
Background technique
Summer and autumn mosquito wreaks havoc, and brings many injuries to the mankind, human body easily causes local skin by bite by mosquitos
Itch, redness, inflammation make one constantly to scratch, and then lead to scar after dermatitis, or even infection.Especially bite by mosquitos causes
Dermatitis it is extremely common.Its skin hypersensitivity generated reaction, mainly from mosquito saliva, venom and secretion, due to wherein
Containing there are many antigenic components, into human skin after can generate allergy with antibody and cause inflammation.
In traditional Chinese medicine, scytitis category caused by bite by mosquitos " disliking sting " scope.Motherland's medicine thinks to be venom
Invade skin, injure channels, channels stasis blocking, QI-blood circulation is unsmooth, it is strongly fragrant and change heat caused by.Main pathological change is poison, the stasis of blood, heat.
Treatment is worked as with anti-evil, the clearing heat and detoxicating, disperse blood stasis and dredge collateral of solid table, dispelling wind and arresting itching for the basic rules for the treatment of.
However, to bite drug (including various paste, spray) absorptivity lower for current mosquito control, need to make for a long time
With therapeutic effect is unobvious.Therefore, it studies that a kind of novel treatment bite by mosquitos effect is good and the drug of few side effects has and weighs
The realistic meaning wanted.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical compositions for treating bite by mosquitos.
The pharmaceutical composition for the treatment of bite by mosquitos provided by the present invention, the raw material that it is made includes the object of following mass parts
Matter: 350~500 parts of fresh purslane, 50~100 parts of fresh mint leaf, 100~200 parts of fresh balsamine leaf, wild chrysanthemum 10
~20 parts and 20 parts of Paris polyphylla.
Further, the raw material that it is made includes the substance of following mass parts: 500 parts of fresh purslane, fresh mint leaf
100 parts, 200 parts of fresh balsamine leaf, 20 parts of wild chrysanthemum and 20 parts of Paris polyphylla.
The pharmaceutical composition of the treatment bite by mosquitos, it further includes sodium carbonate, sodium benzoate and medical that its raw material, which is made,
Alcohol.
Each bulk pharmaceutical chemicals that said medicine is made can be increased according to corresponding ratio as matching in production according to mass parts
It is big or reduce, as large-scale production can by kilogram or as unit of ton, small-scale production can also in grams, and weight can
To increase or reduce, but the bulk pharmaceutical chemicals quality proportioning constant rate between each composition.
The preparation method of the pharmaceutical composition for the treatment of bite by mosquitos of the present invention, includes the following steps:
1) water is added after cleaning the fresh purslane of recipe quantity, fresh mint leaf, fresh balsamine leaf, wild chrysanthemum,
It after smashing broken wall with pulverizer, is saved in 0-4 DEG C of standing, filtering takes supernatant, adds water to be settled to 2000 parts, for use；
2) it by the wild chrysanthemum of recipe quantity and Paris polyphylla cold water soak, then adds water to cook twice, merges decoction liquor, add water fixed
Hold to 500 parts, for use；
3) supernatant that step 1) obtains is obtained decoction liquor with step 2) to mix, carbon then is added into gained mixed liquor
Sour sodium adjusts pH value to 8.5-9；
4) sodium benzoate, medicinal alcohol is added in the mixed liquor then prepared to step 3), is uniformly mixed；
5) sterilizing, it is filling, vacuum packaging to get.
The above method, the additional amount of water described in step 1) are fresh purslane, fresh mint leaf, Flos Impatientis leaf protonatomic mass
The sum of 1~2 times.
In step 1), the pulverizer is crushed 5~10 minutes under 3000 revs/min of revolving speed.
Standing the time saved in step 1) at 0-4 DEG C is 12~24 hours.
The above method, the additional amount of cold water described in step 2) are 2-3 times of the wild chrysanthemum and Paris polyphylla quality, the leaching
The time of bubble is 0.5-2 hours；The condition of the decoction is as follows: decocting the described wild chrysanthemum of amount of water and Paris polyphylla quality twice
2 times -3 times；The time of decoction is 20~30 minutes.
The above method, the dosage of sodium benzoate described in step 4) are that 1~2 gram is added in every liter of mixed liquor；It is described
The dosage of medicinal alcohol is that 150~200 milliliters are added in every liter of mixed liquor.
The above method, the condition of sterilizing described in step 5) are as follows: 80 DEG C are heated 30 minutes.
The medical fluid being prepared by the above process is direct or auxiliary material is added, and can be made into any pharmaceutically acceptable outer
With preparation, for example, liniment, ointment, gelling agent, spray or aerosol external preparation.The drug of above-mentioned various dosage forms
To be prepared according to the conventional method of pharmaceutical field.
Pharmaceutical composition prepared by the present invention can be used for treating various mosquitoes (such as mosquito, hornet, honeybee) bite and poison
Worm (such as centipede) is bitten.In use, direct spraying at bite by mosquitos or affected part, sprays, common mosquito after bite by mosquitos at once
It is primary to bite spraying, malicious mosquito or black mosquito bite sprayed once again every 1 minute,
Compared with prior art, novel treatment bite by mosquitos effect provided by the invention is good and the drug of few side effects has
There is important realistic meaning.
Specific embodiment
The present invention will be described below by way of specific embodiments, but the present invention is not limited thereto, all of the invention
Any modifications, equivalent replacements, and improvements etc. done within spirit and principle, should all be included in the protection scope of the present invention.
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
The drug of embodiment 1, preparation treatment bite by mosquitos
1) 200 grams of leaf of 500 grams+fresh mint of fresh purslane leaf, 100 grams+balsamine clean after plus 800 milliliters it is pure
Water is smashed with pulverizer, wherein 3000 revs/min of pulverizer revolving speed, is crushed 5~10 minutes, the above medical fluid is placed on 4 DEG C after broken wall
Refrigerator, which is stood, to be saved overnight, and filtering takes supernatant, adds pure water to be settled to 2000ml, for use.
2) 20 grams of wild chrysanthemum, 50 grams of Paris polyphylla are taken, with 140 milliliters of cold water soak half an hour, is boiled 20 minutes, taking liquid dries in the air
It is cool, it is repeated once, medical fluid merges twice plus pure water is settled to 500 milliliters, for use.
3) 500 milliliters of medical fluid are taken obtained by 2000 milliliters+step 3) of medical fluid obtained by step 2), mixing, then according to 1 grams per liter
Metered sodium carbonate, adjust pH value to 8.5~9.
4) sodium benzoate is added in the amount in the solution prepared to step 3) according to 1.2 grams per liters, 150 ml ls of amount is added
Medicinal alcohol is uniformly mixed；
5) 80 DEG C of the above medical fluid sterilize 30 minutes, it is filling, vacuum packaging to get.
Embodiment 2, drug therapy mosquito bite observation of curative effect of the present invention
1, observation object and grouping: subject 100.It is randomly divided into treatment group and control group.Treatment group 50, male 26
Example, female 24；Age 1~55 years old.Control group 50, male 28, female 22；Age 1~60 years old.Two groups the age, gender, etc.
Aspect no significant difference (P ﹥ 0.05), is comparable.
2, clinical symptoms: there is small red pimple, redness, bulge in mosquito position of biting.Local itch unbearably, there is hot pain.
3, test material
(1) test sample: drug prepared by the embodiment of the present invention 1
(2) reference substance: mosquito does not sting
4, application method: treatment group and control group are applied to mosquito bite position using test sample, reference substance respectively, and 3~4
It is secondary.
5, criterion of therapeutical effect: effective: clinical symptoms disappear within 30 minutes, and red dot redness disappears, local scratchiness and heat
Pain disappears；Effective: clinical symptoms disappear or substantially reduced substantially in 60 minutes, and red dot disappears substantially, and red and swollen bulge is obvious
It reduces, local scratchiness and heat pain are substantially reduced.Invalid: clinical symptoms do not improve within 4 hours, and red dot does not disappear, red
Swollen bulge is without improvement, and local scratchiness and heat pain are without improvement.
6, experimental result:
Test result shows the treatment mosquito bite drug total effective rate 90% that the present invention is prepared, average 2 minutes scabies
Itch disappearance, 40 minutes red and swollen to disappear.Control group drug total effective rate is 70%, and two groups relatively have significant difference (P ﹤ 0.05),
Above the experimental results showed that the present invention provides drug therapy due to mosquito bites red dot, red and swollen bulge and itch, heat pain tool
There is good curative effect, effect is better than commercial product.Two groups of therapeutic effects are relatively shown in Table 1:
1 two groups for the treatment of mosquito bite Clinical efficacy comparisons of table
| Group | Number of cases (example) | It is effective | Effectively | In vain | Total effective rate |
| Sample sets | 50 | 30 | 15 | 5 | 90% |
| Control group | 50 | 20 | 15 | 15 | 70% |
The insect-bites typical case such as embodiment 3, mosquito
1, so-and-so, Mr. Wang, Liu, Mr. Li etc. of Agricultural University Of Hebei's aquiculture speciality Hao use this product
Before, after mosquito bite, the place of biting will appear the symptoms such as redness, bulge, itch, and itch is hard to bear, and it is unable to bear scratching and grabs, red and swollen bulge
Even 15 talentes can gradually subside after seven days.Make within 10 minutes after mosquito bite interior to be prepared with the embodiment of the present invention 1
Liniment, itch subside after 2 minutes, and red and swollen, bulge is subsided after forty minutes.It carries, is used for multiple times, antipruritic and detumescence curative effect is aobvious
It writes.
2, in Agricultural University Of Hebei, school district, Huanghua, Free distribution crosses 2 trial products, and about 400, service condition and above-mentioned
Unanimously.
3, harbour 50 crewman in PORT OF HUANGHUA use, also consistent with above situation.
4, it to yellow mosquito, is used through colleague, friend up to a hundred people, all reactions very well, can disappear in latter itch 5 minutes on point
It moves back.
5, certain female, 55 years old, people from Baoding are hospitalized by malicious mosquito bite, obvious using rear antipruritic effect, leave hospital in several days.
6, Xinyi friend and its tens people of relatives use, fine to bite by mosquitos effect, and to flower mosquito effect
Clearly.
7, certain male, 50 years old, by hornet sting, is disappeared quickly using keenly feeling after this product.
8, certain female 50 years old, by honeybee sting, is disappeared quickly using keenly feeling after this product, and is generated without swelling.
Claims (10)
1. a kind of pharmaceutical composition for treating bite by mosquitos, the raw material that it is made includes the substance of following mass parts: fresh dent
350~500 parts of amaranth, 50~100 parts of fresh mint leaf, 100~200 parts of fresh balsamine leaf, 10~20 parts of wild chrysanthemum and again
20 parts of building.
2. pharmaceutical composition according to claim 1, it is characterised in that: the raw material that it is made includes the object of following mass parts
Matter: 500 parts of fresh purslane, 100 parts of fresh mint leaf, 200 parts of balsamine leaf, 20 parts of wild chrysanthemum and 20 parts of Paris polyphylla.
3. pharmaceutical composition according to claim 1 or 2, it is characterised in that: the raw material that it is made further includes sodium carbonate, benzene
Sodium formate and medicinal alcohol.
4. the method for preparing pharmaceutical composition as claimed in claim 3, includes the following steps:
1) water is added after cleaning the fresh purslane, fresh mint leaf, fresh balsamine leaf, wild chrysanthemum, uses pulverizer
It after smashing broken wall, is saved in 0-4 DEG C of standing, filtering takes supernatant, adds water to be settled to 2000 parts, for use；
2) it by the wild chrysanthemum and Paris polyphylla cold water soak, then adds water to cook twice, merges decoction liquor, water is added to be settled to 500
Part, for use；
3) supernatant that step 1) obtains is obtained decoction liquor with step 2) to mix, carbonic acid then is added into gained mixed liquor
Sodium adjusts pH value to 8.5-9；
4) sodium benzoate, medicinal alcohol is added in the mixed liquor then prepared to step 3), is uniformly mixed；
5) sterilizing, it is filling, vacuum packaging to get.
5. according to the method described in claim 4, it is characterized by: the additional amount of pure water described in the step 1) is fresh
1~2 times of the sum of purslane, fresh mint leaf, Flos Impatientis leaf protonatomic mass.
6. method according to claim 4 or 5, it is characterised in that: in the step 1), the pulverizer 3000 turns/
Under the revolving speed divided, it is crushed 5~10 minutes；
Standing the time saved in the step 1) at 0-4 DEG C is 12~24 hours.
7. the method according to any one of claim 4-6, it is characterised in that: the addition of cold water described in the step 2)
Amount is 2 times -3 times of Paris polyphylla quality, and the time of the immersion is 0.5-2 hours；The condition of the decoction is as follows: decocting add twice
Water is 2 times -3 times of the Paris polyphylla quality；The time of decoction is 20~30 minutes.
8. the method according to any one of claim 4-7, it is characterised in that: the dosage of sodium benzoate described in step 4)
For 1~2 gram is added in mixed liquor described in every liter；The dosage of the medicinal alcohol is that 150~200 are added in every liter of mixed liquor
Milliliter.
9. the method according to any one of claim 4-8, it is characterised in that: the condition of sterilizing described in the step 5)
Are as follows: 80 DEG C are heated 30 minutes.
10. application of the pharmaceutical composition of any of claims 1-3 in the drug of preparation treatment bite by mosquitos.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910043568.4A CN109498735A (en) | 2019-01-17 | 2019-01-17 | A kind of drug and preparation method thereof for treating bite by mosquitos |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910043568.4A CN109498735A (en) | 2019-01-17 | 2019-01-17 | A kind of drug and preparation method thereof for treating bite by mosquitos |
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| CN109498735A true CN109498735A (en) | 2019-03-22 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472757A (en) * | 2020-12-21 | 2021-03-12 | 韩兵 | Bee venom spray disinfectant and preparation method thereof |
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| CN105287742A (en) * | 2015-10-29 | 2016-02-03 | 广州赛莱拉生物基因工程有限公司 | Ointment capable of controlling mosquito bite and preparation method thereof |
| CN105327079A (en) * | 2015-10-23 | 2016-02-17 | 华润三九医药股份有限公司 | Composition with repairing effect on mosquito bite and application thereof |
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| CN107126446A (en) * | 2016-02-29 | 2017-09-05 | 李林平 | The compound method of bite by mosquitos antipruritic liquid medicine |
| CN108904676A (en) * | 2018-09-04 | 2018-11-30 | 路畅 | A kind of antipruritic antibacterial medical fluid of plant and its preparation method and application |
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2019
- 2019-01-17 CN CN201910043568.4A patent/CN109498735A/en active Pending
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| CN101347395A (en) * | 2008-09-12 | 2009-01-21 | 南京巴黎贝丽丝香水有限公司 | Chinese medicine floral water for preventing and treating bite by mosquitos |
| CN105327079A (en) * | 2015-10-23 | 2016-02-17 | 华润三九医药股份有限公司 | Composition with repairing effect on mosquito bite and application thereof |
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| CN107126446A (en) * | 2016-02-29 | 2017-09-05 | 李林平 | The compound method of bite by mosquitos antipruritic liquid medicine |
| CN106177093A (en) * | 2016-08-26 | 2016-12-07 | 张光光 | A kind of spray for mosquito bite |
| CN108904676A (en) * | 2018-09-04 | 2018-11-30 | 路畅 | A kind of antipruritic antibacterial medical fluid of plant and its preparation method and application |
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| Title |
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| 瞿幸等: "《中医皮肤性病学》", 31 December 2009, 中国中医药出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112472757A (en) * | 2020-12-21 | 2021-03-12 | 韩兵 | Bee venom spray disinfectant and preparation method thereof |
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Application publication date: 20190322 |