CN111686189B

CN111686189B - Plant composition for treating red wind buttocks and application thereof

Info

Publication number: CN111686189B
Application number: CN202010453113.2A
Authority: CN
Inventors: 孙金媛; 王俊林; 陈意平; 赵崇江; 佘弈河
Original assignee: Runben Biotechnology Co ltd
Current assignee: Runben Biotechnology Co ltd
Priority date: 2020-05-25
Filing date: 2020-05-25
Publication date: 2021-11-30
Anticipated expiration: 2040-05-25
Also published as: CN111686189A

Abstract

The invention discloses a plant composition for treating red wind buttocks and application thereof, belonging to the field of cosmetics. According to the invention, the olive leaf extract, the quercus suber extract, the brown algae extract and the dragon blood extract are compounded in a specific proportion, and the synergistic effect among the olive leaf extract, the quercus variabilis extract, the brown algae extract and the dragon blood extract is utilized, so that the effects of diminishing inflammation and diminishing red are achieved in a short time.

Description

Plant composition for treating red wind buttocks and application thereof

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to a plant composition for treating red wind flatus and application thereof.

Background

The skin of the baby is delicate, so that red buttocks are easy to appear when the baby uses the diaper or the diaper for a long time, the diaper rash or the diaper rash is medically known, the clinical manifestations of the diaper rash and the diaper rash are that the skin is red and inflamed, bright red erythema is generated, and papules, blisters and erosion can also occur seriously; if a bacterial infection occurs, pustules may be produced and may sometimes spread to the inner thigh. Therefore, the timely and effective treatment of the red buttocks of the infant is very necessary. The existing baby hip-protecting cream is mainly isolated, for example, petrolatum, wax and the like are adopted, some anti-inflammatory components (such as zinc oxide, plant extracts and the like) are added to relieve inflammation and reduce redness, phenoxyethanol and the like are added to increase the bacteriostatic effect of the product, and a small amount of hormone can be added with quick response.

However, the isolation only has the effect of preventing the red buttocks, and the isolation effect is easily damaged because the excretion frequency of the baby is high. The addition of the anti-inflammatory component can relieve redness and pruritus to a certain extent, but the effect time is long, and the discomfort of the baby is increased. Phenoxyethanol and the like can inhibit the growth of bacteria and microorganisms, and can also affect the normal microbiota of infants after long-term use. Hormones can bring about a good effect, but are also highly destructive to the skin and cannot be used for a long time. Therefore, there is a need for a product for treating red skin in infants which does not burden the skin of infants and which can rapidly take effect in a short time.

Disclosure of Invention

To solve the above-mentioned disadvantages and drawbacks of the prior art, it is an object of the present invention to provide a plant composition for treating red buttocks and use thereof.

In a first aspect, the invention provides a plant composition for treating red wind buttocks, which comprises the following components in parts by weight: 2.5-5 parts of olive leaf extract, 9-15 parts of quercus variabilis extract, 1.5-3 parts of brown seaweed triangle extract and 2-5 parts of dragon blood extract.

The plant composition for treating red wind comprises olive leaf extract with an antibacterial effect, quercus variabilis extract with an anti-inflammatory effect, phaeophyta extract helping to establish a microbial barrier of an infant and dragon blood extract promoting skin healing.

As a preferred embodiment of the plant composition for treating red buttock of the present invention, the plant composition for treating red buttock comprises the following components in parts by weight: 4 parts of olive leaf extract, 12 parts of cork oak extract, 2 parts of brown seaweed triangle extract and 3 parts of dragon blood extract. The four plant extracts have better treatment effect on the red buttock of the infants in the specific mixture ratio.

In a second aspect, the invention provides the use of the above plant composition for treating red buttocks in the preparation of a product for treating red buttocks.

In a third aspect, the invention also provides an infant hip cream which comprises the plant composition for treating red buttocks.

As a preferred embodiment of the infant hip cream, the infant hip cream comprises the following components in percentage by weight: 2.5 to 5 percent of olive leaf extract, 9 to 15 percent of quercus suber extract, 1.5 to 3 percent of brown algae extract and 2 to 5 percent of dragon blood extract. When the infant hip cream contains the olive leaf extract, the quercus suber extract, the brown algae extract and the dragon blood extract in the specific proportion and content, the infant hip cream can produce the effects of diminishing inflammation and fading red in a short time, is natural and safe, and does not cause adverse effects on the skin of an infant.

As a preferred embodiment of the infant hip cream, the infant hip cream comprises the following components in percentage by weight: 4% of olive leaf extract, 12% of quercus suber extract, 2% of brown seaweed triangle extract and 3% of dragon blood extract. Especially, when the infant hip cream contains the olive leaf extract, the quercus variabilis extract, the brown seaweed triangle extract and the dragon blood extract in the specific proportion and content, the treatment effect on the red buttocks of the infant is better.

As a preferred embodiment of the infant hip cream, the infant hip cream further comprises the following components in percentage by weight: 0.078-0.153% of preservative; the antiseptic comprises at least one of cortex Cinnamomi extract, herba Rosmarini officinalis extract, semen glycines seed extract, Mandarin orange pericarp extract, semen Cassiae extract, and herba Menthae extract. The infant hip cream uses natural raw materials as preservatives to prevent the preservatives from generating adverse effects on the skin of an infant.

As a preferred embodiment of the infant hip cream of the present invention, the infant hip cream comprises the following preservatives in percentage by weight: 0.03 to 0.06 percent of cinnamon bark extract, 0.02 to 0.04 percent of rosemary extract, 0.02 to 0.04 percent of soybean seed extract, 0.005 to 0.008 percent of citrus peel extract, 0.003 to 0.005 percent of cassia seed extract and 0.001 to 0.003 percent of mint extract. The cinnamon bark extract, the rosemary extract, the soybean seed extract, the citrus peel extract, the cassia tora seed extract and the mint extract with specific contents are combined with the olive leaf extract, the cork oak extract, the brown seaweed extract and the dragon blood extract, so that a synergistic effect can be generated in the aspect of preservation, and the deterioration of the infant hip cream can be effectively prevented.

As a preferred embodiment of the infant hip cream of the present invention, the infant hip cream comprises 2% to 4% of an emulsifier, 15% to 26.5% of a vegetable fat, 0.5% to 0.8% of a thickener, and 5.85% to 11.7% of a humectant, wherein the emulsifier comprises at least one of inulin lauryl amino acid formate, glycerol stearate citrate, arachidyl glucoside, and cocoyl glucoside; the vegetable oil comprises at least one of coconut oil, Gardenia jasminoides oil, tocopherol, jojoba oil, squalane, shea butter and rice bran oil; the thickener comprises at least one of Caesalpinia Spinosa gum, xanthan gum and Arabic gum, and the humectant comprises at least one of glycerol, sodium hyaluronate, mushroom dextran and snail extract. The infant hip cream takes natural raw materials as an emulsifier, vegetable oil, a thickener and a humectant, does not generate any burden on the skin of an infant, and can be used for daily prevention or skin care of the infant.

As a preferred embodiment of the infant hip cream of the present invention, the infant hip cream further comprises water.

As a preferred embodiment of the infant hip cream of the present invention, the infant hip cream further comprises a balance of water.

As a preferred embodiment of the infant hip cream of the present invention, the infant hip cream comprises the following emulsifiers in percentage by weight: inulin lauryl amino acid formate 2% -4%; the infant hip cream comprises the following vegetable oil in percentage by weight: 8 to 15 percent of coconut oil, 6.5 to 10 percent of tassel flower oil and 0.5 to 1.5 percent of tocopherol; the infant hip cream comprises the following thickeners in percentage by weight: 0.5 to 0.8 percent of Caesalpinia spinosa Gum; the infant hip cream comprises the following humectants in percentage by weight: 5 to 10 percent of glycerin, 0.05 to 0.2 percent of sodium hyaluronate and 0.8 to 1.5 percent of mushroom glucan.

Compared with the prior art, the invention has the following advantages:

(1) the plant composition for treating red wind of the invention is prepared by compounding the olive leaf extract, the quercus suber extract, the brown algae extract and the dragon blood extract in a specific proportion, and the synergistic interaction effect of the olive leaf extract, the quercus variabilis extract, the brown algae extract and the dragon blood extract can achieve the effects of diminishing inflammation and removing red within a short time, and the raw materials are all natural in source, can not generate burden on the skin of an infant, and can be used for daily protection;

(2) the raw materials of the baby hip cream are all natural, the baby hip cream is like the second layer of skin of a baby after being smeared, the generation of red fart can be prevented, the generated red fart can be well treated, in addition, the formula is simple and effective, the preparation process is simple, and the baby hip cream is suitable for industrial mass production.

Detailed Description

The invention is further illustrated by the following examples in order to better illustrate the objects, aspects and advantages of the invention. It is apparent that the following examples are only a part of the embodiments of the present invention, and not all of them. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention.

Example 1

This example is an embodiment of the plant composition for treating red butt, which comprises the following components in parts by weight: 4 parts of olive leaf extract, 12 parts of cork oak extract, 2 parts of brown seaweed triangle extract and 3 parts of dragon blood extract.

Example 2

This example is an embodiment of the plant composition for treating red butt, which comprises the following components in parts by weight: 2.5 parts of olive leaf extract, 9 parts of quercus variabilis extract, 1.5 parts of brown seaweed triangle extract and 2 parts of dragon blood extract.

Example 3

This example is an embodiment of the plant composition for treating red butt, which comprises the following components in parts by weight: 5 parts of olive leaf extract, 15 parts of cork oak extract, 3 parts of brown seaweed triangle extract and 5 parts of dragon blood extract.

Effect example 1: plant extract efficacy assessment

Test objects: 140 infants with diaper rash (0-2 years old) have erythema and pimple on the skin of vulva, buttocks and inner thigh covered by the diaper, and sometimes have invasion, erosion and exudation.

The test method comprises the following steps: the infant diaper rash patients were randomly divided into 7 groups, and the treatment groups were set, wherein the plant composition of example 1, the plant composition of example 2, the plant composition of example 3, the olive leaf extract, the quercus suber extract, the brown algae extract and the dragon blood extract were used for 2 times a day, the thickness was about 1mm-2mm, the treatment groups were kept for 2 hours or more each time, the contaminated site of feces was washed in time after the feces were taken, the drug was applied after the moisture was absorbed, and the effect was observed after one week of the treatment period.

The evaluation criteria for effects were as follows:

the effect is shown: the erosion is obviously reduced within 24 hours, the erosion is healed within 3 days, the skin damage is completely disappeared, and the skin is recovered to be normal;

the method has the following advantages: the erosion is reduced within 3 days, the part of the rash disappears, the erosion heals within 7 days, the rash completely disappears, and the skin is normal;

and (4) invalidation: no improvement, or aggravation within 7 days.

The test results are shown in table 1, wherein the total effective rate is the sum of significant effect and effective cases/total treatment cases × 100%.

TABLE 1

As can be seen from Table 1, the herbal composition of the present invention has a better therapeutic effect on red buttocks of infants, and the treatment groups 1 to 3 have a better therapeutic effect than the treatment groups 4 to 7.

Examples 4 to 6

Examples 4-6, each of which is an embodiment of the infant hip cream of the present invention, have the composition shown in table 2 (in wt%), and are prepared by a method comprising the steps of:

(1) mixing inulin lauryl amino acid formate, coconut oil, flower oil of Gardenia jasminoides Ellis and tocopherol, and heating to 80 deg.C to obtain oil phase;

(2) mixing water, Caesalpinia spinosa gel, glycerol and sodium hyaluronate, heating to 85 ℃, homogenizing for 5min, stirring for 30min under the condition of heat preservation, and dispersing uniformly to obtain a water phase;

(3) mixing the oil phase obtained in the step (1) with the water phase obtained in the step (2), homogenizing for 8min, continuously stirring and cooling, cooling to 42 ℃, adding mushroom glucan, a cinnamon bark extract, a rosemary extract, a soybean seed extract, a citrus peel extract, a cassia tora seed extract, a mint extract, an cork oak extract, a triangular brown algae extract, a dragon blood extract and an olive leaf extract, uniformly stirring, and filtering to obtain the infant hip cream.

TABLE 2

The olive leaf extracts of examples 1-6 were obtained from the chemical company, santa kays, guangzhou under the product model Eurol BT; quercus variabilis extract was obtained from St.Kaes chemical Co., Guangzhou; the brown algae extract is purchased from Oxue chemical Co., Ltd, Guangzhou; the dragon blood extract is purchased from Baihabo Co, Ltd, Guangzhou; cinnamon bark extract, rosemary extract, soybean seed extract, citrus peel extract, cassia tora seed extract, and mint extract were obtained from nature sojourn biotechnology limited of zhayai city.

Effect example 2: evaluation of infant hip cream stability

Test samples: infant hip cream in examples 4-6.

The test method comprises the following steps: the test of heat resistance, cold resistance and circulation stability is carried out according to the execution standard of the skin-moistening cream QB/T1857-2013, which is as follows:

1. and (3) heat resistance test: placing the sample in an environment of 48 ℃, standing for 90 days and observing;

2. cold resistance test: placing the sample in an environment of-10 ℃, standing for 90 days, and observing;

3. and (3) cycle testing: placing the sample in an environment of 48 ℃, standing for 12 hours, and then placing the sample in an environment of-10 ℃ and standing for 12 hours; the cycle was repeated three times in succession.

And (3) testing results: as shown in table 3.

TABLE 3

Group of	Heat resistance	Cold-resistant	Circulation of
				Example 4	Stabilization	Stabilization	Stabilization
Example 5	Stabilization	Stabilization	Stabilization
				Example 6	Stabilization	Stabilization	Stabilization

Effect example 3: corrosion challenge test

Test samples: infant hip cream in examples 4-6.

The test method comprises the following steps: reference is made to the 28d preservative single challenge test recommended by the cosmetics and fragrance association (CTFA) as a test standard.

And (3) testing results: as shown in table 4.

TABLE 4

As can be seen from table 4, the infant hip cream in examples 4-6 all pass the microbial preservation challenge test, and the plant extracts in the hip cream have better preservation effect.

Effect example 4: evaluation of baby hip cream safety

Test samples: infant hip cream in examples 4-6.

The test substance: 12 common New Zealand white rabbits with the weight of 1.80 Kg-2.2 Kg are provided by the Dongxin laboratory animal farm in the Kyowa Huadu district of Guangzhou city, and each group of examples has 4 rabbits.

The test method comprises the following steps: (1) the back hair on two sides of the spine of the back of the rabbit is removed 24 hours before the experiment, the skin surface is not damaged, and the hair removal ranges are respectively 3cm multiplied by 3 cm; (2) smearing 0.5g of the test substance on one side of skin with a smearing area of 2.5cm × 2.5cm, and smearing on the other side of skin as control group for 1 time per day for 14 days; and (3) shearing hair from the next day before each smearing, and removing residual test substances by using pure water. The results were observed after one hour and scored according to the skin irritation scoring standard of technical Specification for cosmetic safety (2015 edition).

And (3) testing results: as shown in table 5.

TABLE 5

As can be seen from table 5, the baby hip-care creams of examples 4 to 6 are non-irritating, do not cause additional burden to the skin of the baby in long-term use, and can protect the skin of the baby.

Effect example 5: evaluation of clinical effects of infant hip cream

Test objects: in 100 cases of infants with diaper rash (0-2 years old), erythema and pimple appear on the skin of the vulva, buttocks and inner thighs covered by the diaper, and sometimes invasion, erosion and exudation are accompanied.

The test method comprises the following steps: dividing 100 children patients into 5 groups, respectively, using hip cream in examples 4-6 for test groups 1-3, zinc oxide ointment with commercial content of 15% for control group 1, and mupirocin ointment for control group 2; the preparation is administered 2 times per day, has a thickness of about 1mm-2mm, is retained for more than 2 hours each time, is used for cleaning contaminated part of feces after relieving bowels, is applied after absorbing water, and is observed after one week.

And (3) testing results: see table 6, wherein the total effective rate is the sum of significant effect and effective cases/total treatment cases × 100%.

TABLE 6

Group of	Significant effect (%)	Effective (%)	Null (%)	Total effective rate (%)
					Example 4	30	55	15	85
Example 5	45	50	5	95
					Example 6	40	50	10	90
Control group 1	20	55	25	75
					Control group 2	35	55	10	90

As can be seen from Table 6, the baby hip-pads cream of examples 4-6 has better therapeutic effect, and the therapeutic effect is more prominent within 3 days compared with the zinc oxide ointment; examples 4-6 the therapeutic effect of the infant hip cream was close to that of the hormone.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. The external plant composition for treating red wind buttocks is characterized by being prepared from the following raw materials in parts by weight: 2.5-5 parts of olive leaf extract, 9-15 parts of quercus variabilis extract, 1.5-3 parts of brown seaweed triangle extract and 2-5 parts of dragon blood extract.

2. The external plant composition for treating red buttocks according to claim 1, is prepared from the following raw materials in parts by weight: 4 parts of olive leaf extract, 12 parts of cork oak extract, 2 parts of brown seaweed triangle extract and 3 parts of dragon blood extract.

3. Use of a topical botanical composition for the treatment of red buttocks according to claim 1 or 2 in the manufacture of a product for the treatment of red buttocks.

4. An infant hip cream characterized in that it comprises the external plant composition for treating red buttocks of claim 1 or 2 as an active ingredient.

5. The infant hip cream according to claim 4, wherein the active ingredients of the infant hip cream are prepared from the following raw materials in percentage by weight: 2.5 to 5 percent of olive leaf extract, 9 to 15 percent of quercus suber extract, 1.5 to 3 percent of brown algae extract and 2 to 5 percent of dragon blood extract.

6. The infant hip cream according to claim 5, wherein the active ingredients of the infant hip cream are prepared from the following raw materials in percentage by weight: 4% of olive leaf extract, 12% of quercus suber extract, 2% of brown seaweed triangle extract and 3% of dragon blood extract.

7. The infant hip cream according to claim 5 or 6, further comprising the following components in percentage by weight: 0.078-0.153% of preservative; the antiseptic is cortex Cinnamomi extract, herba Rosmarini officinalis extract, semen glycines seed extract, Mandarin orange pericarp extract, semen Cassiae seed extract and herba Menthae extract.

8. The infant hip cream according to claim 7, characterized in that it comprises the following preservatives in weight percentage: 0.03 to 0.06 percent of cinnamon bark extract, 0.02 to 0.04 percent of rosemary extract, 0.02 to 0.04 percent of soybean seed extract, 0.005 to 0.008 percent of citrus peel extract, 0.003 to 0.005 percent of cassia seed extract and 0.001 to 0.003 percent of mint extract.

9. The infant hip cream according to claim 8, further comprising the following components in percentage by weight: 2% -4% of an emulsifier, 15% -26.5% of vegetable fat, 0.5% -0.8% of a thickening agent and 5.85% -11.7% of a humectant, wherein the emulsifier comprises at least one of inulin lauryl amino acid formate, glycerol stearate citrate, arachidyl glucoside and coco glucoside; the vegetable oil comprises at least one of coconut oil, Gardenia jasminoides oil, tocopherol, jojoba oil, squalane, shea butter and rice bran oil; the thickener comprises at least one of Caesalpinia Spinosa gum, xanthan gum and Arabic gum, and the humectant comprises at least one of glycerin, sodium hyaluronate, mushroom dextran and snail extract; the infant hip cream further comprises water.

10. The infant hip cream according to claim 9, characterized in that it comprises the following emulsifiers in weight percentage: inulin lauryl amino acid formate 2% -4%; the infant hip cream comprises the following vegetable oil in percentage by weight: 8 to 15 percent of coconut oil, 6.5 to 10 percent of tassel flower oil and 0.5 to 1.5 percent of tocopherol; the infant hip cream comprises the following thickeners in percentage by weight: 0.5 to 0.8 percent of Caesalpinia spinosa Gum; the infant hip cream comprises the following humectants in percentage by weight: 5 to 10 percent of glycerin, 0.05 to 0.2 percent of sodium hyaluronate and 0.8 to 1.5 percent of mushroom glucan; the infant hip cream further comprises the balance of water.