CN114681353A - Skin itching-relieving and soothing liquid suitable for infants and preparation method thereof - Google Patents

Skin itching-relieving and soothing liquid suitable for infants and preparation method thereof Download PDF

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Publication number
CN114681353A
CN114681353A CN202011627488.2A CN202011627488A CN114681353A CN 114681353 A CN114681353 A CN 114681353A CN 202011627488 A CN202011627488 A CN 202011627488A CN 114681353 A CN114681353 A CN 114681353A
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component
relieving
itching
liquid
skin
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李易春
覃艳艳
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GUANGDONG YIMING PHARMACEUTICAL CO Ltd
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GUANGDONG YIMING PHARMACEUTICAL CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to the technical field of skin care products, in particular to a skin itching-relieving and soothing liquid suitable for infants, which is used for solving the problems that the existing itching-relieving and soothing liquid has poor itching-relieving and detumescence effects, is irritant to skin and cannot repair mosquito bite scar muscles after being smeared; the invention provides a liquid for relieving itching and soothing skin suitable for infants, which is an itching relieving and soothing liquid prepared from water, propylene glycol, licorice root extract, gentian root extract, sophora flavescens root extract, cnidium fruit extract and artemisia apiacea extract, a humectant consisting of butanediol and glycosphingolipids, a surfactant consisting of water, propylene glycol, nonylphenol polyether-14 and PEG-50 castor oil and other additives; the itching relieving sustained release preparation adopts pure natural plant extracts, is safe, has no side effect, is suitable for infants and other people with fragile skin, and can be used for preventing mosquito bites and relieving itching and repairing after mosquito bites.

Description

Skin itching-relieving and soothing liquid suitable for infants and preparation method thereof
Technical Field
The invention relates to the technical field of skin care products, and particularly relates to a skin itching-relieving soothing liquid suitable for infants and a preparation method thereof.
Background
The skin of infants is characterized by low skin immunity, sensitivity and fragility, and belongs to the skin immunity fluctuation stage. The outstanding features of the skin of the infants at this stage are the change of the bacteriostatic ability of the skin, the immunity brought by the parents in nature is gradually weakened, the autoimmunity of the infants is still in the sprouting stage, and the immunity of the skin is low. Infants metabolize fast and are more easily bitten by mosquitoes, so that the bitten part is itchy, wrapped and red.
At present, a lot of products for relieving itching exist in the market, but most of the products are refined by chemical raw materials, contain a large amount of substances harmful to human bodies, cannot ensure safety, and are easy to cause other health problems particularly for infants. In addition, the product cannot achieve the effects of quickly sterilizing and relieving itching during use, and phenomena such as allergy, red swelling and the like can occur.
Disclosure of Invention
The invention aims to overcome at least one defect (deficiency) of the prior art, provides the skin itching-relieving soothing liquid suitable for infants and the preparation method thereof, achieves the effects of sterilizing, relieving itching, resisting inflammation, diminishing swelling, desalting bite bags and repairing scar muscles, is extracted by pure natural plants, is safe and non-irritant, and is particularly suitable for infants.
The invention adopts the technical scheme that the skin itching-relieving and soothing liquid suitable for infants comprises the following components in parts by weight:
the component A comprises:
Figure BDA0002877820850000011
Figure BDA0002877820850000021
and B component:
Figure BDA0002877820850000022
the invention provides a skin itching relieving and soothing liquid suitable for infants, trehalose can form a protective barrier on epidermal cells to keep the vitality of the cells, glycerin can accelerate the healing of the skin, reduce inflammation and restore the normal barrier function of the skin, and trehalose and glycerin have synergistic effect to accelerate the healing of damaged skin and restore the barrier function; allantoin and aloe extract have certain effects of sterilizing, relieving itching and diminishing inflammation, and can prevent skin infection; the camphor can expel insects and avoid being bitten by mosquitoes; the antipruritic sustained release substance comprises a plurality of active ingredients which are extracted from pure nature, has broad-spectrum antibacterial property, and can kill parasites, relieve itching, resist inflammation and reduce swelling. The skin itching relieving and soothing liquid suitable for infants is used for preventing mosquito bites or quickly diminishing inflammation and swelling after being bitten by mosquitoes, sterilizing and relieving itching, fading bite bags, repairing scar muscles and the like.
Further, the itching relieving sustained release material in the component C is prepared from water, propylene glycol, licorice root extract, gentian root extract, sophora flavescens root extract, cnidium fruit extract and sweet wormwood herb extract according to the weight ratio of 35: 60: 1: 1: 1: 1: 1, and preparing the composition.
Water and propylene glycol as solvent, which is favorable for the solubility of licorice root extract, gentian root extract, sophora flavescens root extract, cnidium fruit extract, sweet wormwood herb extract and the like; the licorice root extract is used as an anti-inflammatory agent, has high safety factor, is suitable for people with fragile skin, and is particularly suitable for infants; the radix Gentianae extract is gentiopicroside extracted from root and polar stem of radix Gentianae of Gentianaceae, and has good antipruritic and repercussive effects; the sophora flavescens extract has the insecticidal effect, has a good relieving effect on skin itch, promotes the growth and repair of damaged vascular nerve cells, and restores the activity of subcutaneous capillary blood vessel cells; the snake fruit extract is used as an antibacterial agent with high safety coefficient, is compounded with other components for mutual promotion, and can quickly and effectively play the effects of resisting bacteria, diminishing inflammation and relieving itching.
Further, the humectant in the component C is prepared from butanediol and glycosphingolipids according to the weight ratio of 11: 1, preparing the medicament.
The butanediol is used as a common solvent humectant, the glycosphingolipids can effectively improve the adhesive force of keratinocytes, enable the cells to be tightly combined and reduce the water loss, and the composition of the butanediol and the glycosphingolipids is used as the humectant, can effectively slow down the volatilization of itching relieving and soothing liquid and prolong the effect of the composition.
Further, the surfactant in the component D is prepared from water, propylene glycol, nonylphenol polyether-14, PEG-50 castor oil, and the weight ratio of 6: 5: 5: 4, preparing the composition.
Preferably, the composition comprises the following components in parts by weight:
the component A comprises:
Figure BDA0002877820850000031
and B component:
Figure BDA0002877820850000032
Figure BDA0002877820850000041
a preparation method of the skin itching-relieving and soothing liquid suitable for infants comprises the steps of fully dissolving the component A, adding the B, C component, stirring to fully mix, adding the D component which is treated and fully dissolved in advance, stirring to uniformly mix, filtering and discharging after sampling and detecting to be qualified, and storing.
Further, the method specifically comprises the following steps:
s1: heating the component A to 80 ℃, and fully dissolving;
s2: cooling to 60 deg.C after stirring to dissolve completely, and adding B, C components;
s3: pretreating the component D material, heating to 80 ℃ to completely dissolve the component D material, cooling to 40 ℃, and adding the component D into the mixed component of S2 to complete component mixing;
s4: and (4) cooling the mixed components in the step S3 to below 35 ℃, filtering and discharging after sampling detection is qualified, and thus obtaining the relieving liquid.
Compared with the prior art, the invention has the beneficial effects that:
1) the itching relieving sustained release substance adopts pure natural plant extracts, is safe, has no side effect, and is suitable for infants and other people with fragile skin;
2) the skin itching relieving liquid can be used for preventing mosquito bites and also can be used for itching relieving repair after mosquito bites.
Detailed Description
The examples of the present invention are provided for illustrative purposes only and are not to be construed as limiting the invention.
Example 1
The skin itching-relieving and soothing liquid suitable for infants comprises the following components in parts by weight:
the component A comprises:
Figure BDA0002877820850000042
and B component:
Figure BDA0002877820850000051
wherein, the antipruritic slow-release substance is as follows:
Figure BDA0002877820850000052
example 2
The skin itching-relieving and soothing liquid suitable for infants comprises the following components in parts by weight:
the component A comprises:
Figure BDA0002877820850000061
and B component:
0.5 part of 1, 2-hexanediol;
0.5 part of p-hydroxyacetophenone;
and (C) component:
0.4 part of antipruritic sustained release material;
0.1 part of humectant;
and (D) component:
Figure BDA0002877820850000062
wherein, the antipruritic sustained release substance is:
Figure BDA0002877820850000063
Figure BDA0002877820850000071
wherein, the humectant is:
0.095 part of butanediol;
0.005 part of glycosphingolipids;
wherein the surfactant is:
Figure BDA0002877820850000072
example 3
The skin itching-relieving and soothing liquid suitable for infants comprises the following components in parts by weight:
the component A comprises:
Figure BDA0002877820850000073
and B component:
0.5 part of 1, 2-hexanediol;
0.5 part of p-hydroxyacetophenone;
and C, component C:
0.6 part of antipruritic sustained release material;
0.2 part of humectant;
and (D) component:
Figure BDA0002877820850000074
Figure BDA0002877820850000081
wherein, the antipruritic sustained release substance is:
Figure BDA0002877820850000082
wherein, the humectant is:
0.19 part of butanediol;
0.1 part of glycosphingolipids;
wherein the surfactant is:
Figure BDA0002877820850000083
test one:
30 newborn mice were selected and divided into 5 groups and labeled, wherein three groups were used as test groups, and the three groups were applied with the anti-itch soothing liquid prepared in example 1, example 2, and example 3, respectively, while the control group was applied with ordinary toilet water and the blank group was not treated at all.
30 newborn mice were placed in an experimental environment with mosquitoes, and the conditions of stinging and swelling on the epidermis were observed after one hour. Experiments show that the skin of a white mouse in a blank group has the largest number of stings and red swelling, the skin of a white mouse in a control group has relatively small number of stings and red swelling, but part of the white mouse has an allergy phenomenon, and the skin of a test group has the smallest number of stings and red swelling and has no allergy phenomenon.
And (2) test II:
20 newborn mice are placed in an experimental environment with mosquitoes, and when the skins of the mice have more stings and red swelling, the mice are divided into 4 groups, wherein three groups are used as experimental groups and are respectively smeared with the itching relieving and relieving liquid prepared in the embodiment 1, the embodiment 2 and the embodiment 3, the other group is used as a control group and is smeared with common toilet water, and the stings and red swelling on the skins of the mice of each group are respectively observed after 1 hour and 2 hours. Experiments show that after 1 hour, the bites and the red swelling of the white mice in the test group are mostly removed, other allergic symptoms are not appeared, and the bites still have marks; the biting and swelling parts of the white mice in the control group are removed, the biting trace is obvious, and the allergy phenomenon appears in part of the white mice; after 2 hours, the bites and the redness of the white mice in the test group basically subside, and most of the bites on the epidermis can not be seen; the white mouse bites and red swelling of the control group still have more unremoved conditions, and the bites still exist at the partially removed bites and red swelling positions.
Therefore, the skin itching relieving and soothing liquid has a good effect on preventing mosquito bites or itching relieving edema caused by mosquito bites, does not generate any stimulation on skin, is safe and has no side effect, and also has the effect of repairing scar muscles.
It should be understood that the above-mentioned embodiments of the present invention are only examples for clearly illustrating the technical solutions of the present invention, and are not intended to limit the specific embodiments of the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention claims should be included in the protection scope of the present invention claims.

Claims (7)

1. The skin itching-relieving and soothing liquid suitable for infants is characterized by comprising the following components in parts by weight:
the component A comprises:
Figure FDA0002877820840000011
and B component:
0.4-0.7 part of 1, 2-hexanediol;
0.3-0.6 part of p-hydroxyacetophenone;
and C, component C:
0.4-0.6 part of itching relieving sustained release material;
0.1-0.2 parts of a humectant;
and (D) component:
Figure FDA0002877820840000012
2. the liquid as claimed in claim 1, wherein the sustained release antipruritic substance in the C component is prepared from water, propylene glycol, radix Glycyrrhizae extract, radix Gentianae extract, radix Sophorae Flavescentis extract, fructus Cnidii extract, and herba Artemisiae Annuae extract in a ratio of 35: 60: 1: 1: 1: 1: 1, and preparing the composition.
3. The liquid as claimed in claim 1, wherein the moisturizer in the C component is selected from butylene glycol, glycosphingolipids in a ratio of 11: 1, and preparing the composition.
4. The liquid as claimed in claim 1, wherein the surfactant in component D is selected from water, propylene glycol, nonylphenol polyether-14, PEG-50 castor oil, and a mixture of 6: 5: 5: 4, preparing the composition.
5. The liquid for relieving itching and soothing skin suitable for infants according to any one of claims 1 to 4, which is characterized by comprising the following components in parts by weight:
the component A comprises:
Figure FDA0002877820840000021
and B component:
0.5 part of 1, 2-hexanediol;
0.5 part of p-hydroxyacetophenone;
and C, component C:
0.5 part of antipruritic sustained release material;
0.15 part of humectant;
and (D) component:
Figure FDA0002877820840000022
6. a method for preparing the liquid for relieving itching and soothing skin of infants and young children as claimed in any one of claims 1 to 5, wherein the component A is fully dissolved, the component B, C is added and stirred to be fully mixed, the component D which is treated and fully dissolved in advance is added and stirred to be uniformly mixed, and after sampling and detection are qualified, the liquid is filtered, discharged and stored.
7. The method for preparing the liquid for relieving itching and soothing skin suitable for infants according to claim 6, which comprises the following steps:
s1: heating the component A to 80 ℃, and fully dissolving;
s2: cooling to 60 deg.C after stirring to dissolve completely, and adding B, C components;
s3: pretreating the component D material, heating to 80 ℃ to completely dissolve the component D material, cooling to 40 ℃, and adding the component D into the mixed component of S2 to complete component mixing;
s4: and (4) cooling the mixed components in the step S3 to below 35 ℃, filtering and discharging after sampling detection is qualified, and thus obtaining the relieving liquid.
CN202011627488.2A 2020-12-31 2020-12-31 Skin itching-relieving and soothing liquid suitable for infants and preparation method thereof Pending CN114681353A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115607493A (en) * 2022-10-19 2023-01-17 广州伽能生物科技有限公司 Itching-relieving and soothing composition and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104784223A (en) * 2015-01-28 2015-07-22 广西博科药业有限公司 Composition with itching removing function and preparation method thereof
CN108272696A (en) * 2018-04-15 2018-07-13 啵噜噜（广州）婴儿用品科技有限公司 A kind of external preparation with mosquito-expelling and antipruritic
CN108420929A (en) * 2018-04-15 2018-08-21 啵噜噜（广州）婴儿用品科技有限公司 A kind of external preparation with the miliaria itching-relieving action that relaxes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104784223A (en) * 2015-01-28 2015-07-22 广西博科药业有限公司 Composition with itching removing function and preparation method thereof
CN108272696A (en) * 2018-04-15 2018-07-13 啵噜噜（广州）婴儿用品科技有限公司 A kind of external preparation with mosquito-expelling and antipruritic
CN108420929A (en) * 2018-04-15 2018-08-21 啵噜噜（广州）婴儿用品科技有限公司 A kind of external preparation with the miliaria itching-relieving action that relaxes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115607493A (en) * 2022-10-19 2023-01-17 广州伽能生物科技有限公司 Itching-relieving and soothing composition and preparation method thereof
CN115607493B (en) * 2022-10-19 2023-08-08 广州伽能生物科技有限公司 Itching-relieving and soothing composition and preparation method thereof

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