CN114569516B - Itching relieving and inflammation diminishing composition, itching relieving and inflammation diminishing wet tissue and preparation method thereof - Google Patents
Itching relieving and inflammation diminishing composition, itching relieving and inflammation diminishing wet tissue and preparation method thereof Download PDFInfo
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- CN114569516B CN114569516B CN202210331704.1A CN202210331704A CN114569516B CN 114569516 B CN114569516 B CN 114569516B CN 202210331704 A CN202210331704 A CN 202210331704A CN 114569516 B CN114569516 B CN 114569516B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an antipruritic and anti-inflammatory composition, an antipruritic and anti-inflammatory wet wipe and a preparation method thereof. The itching-relieving and inflammation-diminishing composition comprises the following components in parts by weight: 20-25 parts of desmodium extract, 11-16 parts of rhodiola sachalinensis extract, 9-14 parts of nepenthes extract, 8-15 parts of ash grass extract, 6-12 parts of mung bean extract, 15-25 parts of wild chrysanthemum flower extract, 11-19 parts of mint extract and 13-18 parts of radix sophorae flavescentis extract. The invention combines the desmodium extract, the rhodiola sachalinensis extract, the nepenthes extract, the ash grass extract, the mung bean extract, the wild chrysanthemum extract, the peppermint extract and the kuh-seng extract, and the synergistic effect among the components can realize the effects of relieving itching and pain, diminishing inflammation and sterilizing and improving the moisturizing and skin care together. The antipruritic and anti-inflammatory composition is applied to the wet tissues, so that the wet tissues have the effects of relieving itching, diminishing inflammation, preserving moisture and protecting skin, and are convenient to carry and use while being effectively cleaned.
Description
Technical Field
The invention belongs to the technical field of itching-relieving and inflammation-diminishing skin care products, and particularly relates to an itching-relieving and inflammation-diminishing composition, itching-relieving and inflammation-diminishing wet tissues and a preparation method thereof.
Background
With the improvement of living standard and the natural love of people, people enjoy the outdoor psychology, and the outdoor activities of people are increased. But the trouble of invasion of mosquitoes is also avoided during activities. Because of the danger of spreading various diseases to mosquitoes, people also expand the control of mosquitoes from indoor to outdoor. At present, common mosquito repellent products in the market are spray type and combustible mosquito repellent incense and the like. However, the liquid is not easy to carry on the airplane, and the mosquito-repellent incense which can be used only after being ignited is extremely inconvenient to use. Therefore, there is a need to develop a wet tissue with the functions of relieving itching, diminishing inflammation and protecting skin, so that the wet tissue has the effects of relieving itching, diminishing inflammation, being convenient to carry and being convenient to use while being effectively cleaned.
However, most of the existing skin antipruritic and anti-inflammatory products are antibacterial drugs, such as antibiotics, which can cause drug resistance and influence health after long-term use. In order to meet the requirement of product safety, the effective components of the antipruritic and anti-inflammatory composition are often plant extracts, but the plant extracts contain a plurality of substances, and unknown components exist in the plant extracts, so that the mutual inhibition of effects possibly exists in the compounding of the plant extracts, and products with excellent bactericidal and anti-inflammatory effects and skin care effects are not many in the market.
Disclosure of Invention
The invention aims to provide an antipruritic and anti-inflammatory composition, an antipruritic and anti-inflammatory wet wipe and a preparation method thereof aiming at the defects of the prior art.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: an antipruritic and anti-inflammatory composition comprises the following components in parts by weight: 20-25 parts of desmodium extract, 11-16 parts of rhodiola sachalinensis extract, 9-14 parts of nepenthes extract, 8-15 parts of ash grass extract, 6-12 parts of mung bean extract, 15-25 parts of wild chrysanthemum flower extract, 11-19 parts of mint extract and 13-18 parts of radix sophorae flavescentis extract.
The herba Lysimachiae Christinae extract mainly contains phenolic components, sterols, flavonoids, amino acids, tannins, volatile oil and choline, etc., and the flavonoids contained in herba Lysimachiae Christinae have antiinflammatory effect, and can be used for treating some inflammatory diseases. In addition, the herba Lysimachiae Christinae extract has effect in inhibiting pneumococcus and Staphylococcus aureus, and thus enhancing immunity.
The radix Rhodiolae extract has effects of clearing heat and detoxicating, and can effectively relieve fever, poisoning and rubella, and eliminate red swelling caused by insect bite.
The nepenthes extract contains flavonoid glycoside, phenols, amino acids, saccharides, anthraquinone glycoside and other components, has the effects of detoxifying and running water, has the effects of diminishing inflammation and detoxifying, and can be used for resisting inflammation and preventing and treating mosquito bites.
The herba Chenopodii extract contains high content of vitamins and carotene, so that the immunity of human body can be enhanced, the probability of illness is reduced, and the herba Chenopodii extract has a certain diuretic effect, and can timely discharge toxins in the body, so as to clear away heat and toxic materials and remove fire in the body.
The tannin contained in the mung bean extract can coagulate microorganism protoplasm and can generate antibacterial activity; biologically active substances such as flavonoid compounds, plant sterols and the like also have antibacterial and antiviral effects to a certain extent; the mung bean contains many bioactive substances such as coumarin, alkaloid, phytosterol, and saponin, which can enhance immunity and increase phagocyte number or phagocyte function.
The wild chrysanthemum extract has a certain resistance to bacteria and viruses and an inhibition effect to staphylococcus aureus, shigella flexneri and typhoid bacillus; has inhibiting effect on Streptococcus hemolyticus and Escherichia coli, and has various degrees of inhibiting effects on Bacillus diphtheriae, bacillus dysenteriae and Bacillus proteus.
Peppermint extract, which can cool skin and stimulate nerve endings, so as to activate skin cells and make skin elastic, smooth and plump; in addition, because of its pungent and cool taste, it can inhibit dermatophytes and eliminate skin urticaria and itching symptoms.
The kuh-seng root extract has broad-spectrum antibacterial property, can inhibit the biosynthesis of thalli, and can influence the biological oxidation process of the thalli. The anti-inflammatory mechanism of the kuh-seng extract is caused by the stabilization of erythrocyte membranes, has a strong immunoregulatory effect, can exert the anti-inflammatory effect by the influence of the change of immune cells, cytokines and other inflammatory regulatory factors, has good curative effects on eczema and dermatitis, and can relieve skin itch caused by inflammation.
The invention combines the desmodium extract, the rhodiola sachalinensis extract, the nepenthes extract, the ash grass extract, the mung bean extract, the wild chrysanthemum extract, the peppermint extract and the kuh-seng extract, and the synergistic effect among the components can realize the effects of relieving itching and pain, diminishing inflammation and sterilizing and improving the moisturizing and skin care together.
In addition, the invention also provides a preparation method of the antipruritic and anti-inflammatory composition, which comprises the following steps:
(1) Mixing radix Rhodiolae extract, semen Phaseoli Radiati extract, flos Chrysanthemi Indici extract, herba Menthae extract and radix Sophorae Flavescentis extract at room temperature to obtain mixture I;
(2) Cooling the mixture I, adding herba Lysimachiae Christinae extract and herba Nepetae extract, and mixing well; obtaining a mixture II;
(3) Placing the mixture II in a light-proof closed environment, adding herba Chenopodii chinensis extract, and mixing uniformly to obtain the antipruritic and antiinflammatory composition.
As a preferred embodiment of the present invention, in the step (2), the temperature after cooling is 5-15 ℃.
The preparation method of the antipruritic and anti-inflammatory composition can avoid the loss of active ingredients in the preparation process, thereby ensuring the maximization of the efficacy of the antipruritic and anti-inflammatory composition as much as possible.
The invention claims the application of the antipruritic and anti-inflammatory composition in antipruritic and anti-inflammatory wet tissues.
The itching relieving and inflammation diminishing wet tissue comprises the itching relieving and inflammation diminishing composition.
As a preferred embodiment of the invention, the itching relieving and inflammation diminishing composition comprises 10-24% by mass of the itching relieving and inflammation diminishing wet tissues.
The inventor finds that when the content of the antipruritic and anti-inflammatory composition is 10-24%, the antipruritic and anti-inflammatory effects of the wet tissues are optimal, and the wet tissues have certain moisturizing effects.
As a preferred embodiment of the invention, the itching relieving and inflammation diminishing wet tissues also comprise the following components in percentage by mass: emulsifying agent 1.5-4.0 wt% and surfactant 0.5-1.3 wt%.
The interaction of the emulsifier and the surfactant can preferentially remove greasy dirt and impurities on the surface of the skin, so that the itching-relieving and inflammation-diminishing composition can directly act on the skin, and the itching-relieving, inflammation-diminishing and moisture-preserving effects of the composition are accelerated. Meanwhile, the inventor discovers that the ratio of the emulsifier to the surfactant is within the limit range of the invention through the ratio regulation and control of the emulsifier to the surfactant, and the antipruritic, antibacterial and antibacterial effective time of the antipruritic and anti-inflammatory wet tissues is obviously improved.
As a preferred embodiment of the present invention, the surfactant is at least one of decyl glucoside, polysorbate 20, cocoamidopropyl betaine; the emulsifier is PEG-7 glycerol cocoate.
As a preferred embodiment of the invention, the itching relieving and inflammation diminishing wet tissues also comprise the following components in percentage by mass: 2.0-5.2% of humectant and 0.2-0.5% of antioxidant.
According to the invention, the humectant and the antioxidant are compounded, so that the effective action time of the itching-relieving and inflammation-diminishing composition can be effectively prolonged, the proportion of the humectant to the antioxidant is within the limit range of the invention, the itching-relieving, antibacterial and moisturizing effects of the obtained itching-relieving and inflammation-diminishing wet tissue are obviously improved, and the antibacterial effective action time is longer.
As a preferred embodiment of the present invention, the humectant is at least one of glycerin, polyglycerol, xylitol glucoside, avocado oil, and propylene glycol; the antioxidant is p-hydroxyacetophenone.
As a preferred embodiment of the invention, the itching relieving and inflammation diminishing wet tissues also comprise the following components in percentage by mass: 20-35% of non-woven fabric, 0.3-0.9% of skin softening agent, 0.03-0.9% of preservative, 0.05-0.3% of nutrient, 0.05-0.7% of pH regulator and the balance of water.
As a preferred embodiment of the invention, the skin softening agent is at least one of aloe extract, PEG/PPG-14/7 dimethyl ether and C12-15 alcohol benzoate; the nutritional agent is vitamin E acetate; the antiseptic is at least one of cetyl pyridinium chloride, polychloropropyl biguanide, chlorpheniramine, benzoic acid, phenoxyethanol and chamomile extract; the pH regulator is triethanolamine.
The invention also claims a preparation method of the itching relieving and inflammation diminishing wet tissue, which comprises the following steps:
(1) Stirring a pH regulator and water for 3-5min at normal temperature to form a regulating solution;
(2) Stirring the skin softening agent, the humectant, the antioxidant, the emulsifier, the preservative, the nutrient, the surfactant and the water for 8-15min in a sealing way to obtain a first mixed material;
(3) Mixing the antipruritic and anti-inflammatory composition with the first mixed material, and sealing and stirring for 5-10min to obtain a second mixed material;
(4) Mixing the regulating solution with the second mixed material, supplementing water, and sealing and stirring for 5-10min to obtain antipruritic and antiinflammatory solution;
(5) And superposing the non-woven fabrics together, and then pouring the antipruritic and anti-inflammatory solution on the non-woven fabrics until the non-woven fabrics are completely absorbed.
Compared with the prior art, the invention has the beneficial effects that:
(1) The invention combines the desmodium extract, the rhodiola sachalinensis extract, the nepenthes extract, the ash grass extract, the mung bean extract, the wild chrysanthemum extract, the peppermint extract and the kuh-seng extract, and the synergistic effect among the components can realize the effects of relieving itching and pain, diminishing inflammation and sterilizing and improving the moisturizing and skin care together.
(2) The interaction of the emulsifier and the surfactant in the wet tissue can remove greasy dirt and impurities on the surface of skin preferentially, so that the itching-relieving and inflammation-diminishing composition can directly act on the skin, and the itching-relieving, inflammation-diminishing, sterilization and moisture-preserving effects of the composition are accelerated. Meanwhile, after the antipruritic and anti-inflammatory composition acts, the humectant and the antioxidant in the wet tissues can effectively prolong the effective acting time of antibiosis.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
Unless specifically stated otherwise, the reagents, methods and apparatus employed in the present invention are those conventional in the art. The reagents and materials used in the present invention are commercially available unless otherwise specified.
The following raw materials are adopted in the examples and comparative examples of the invention:
desmodium extract: brand number: PF005806, available from Sesamum indicum Biotechnology Co., ltd;
extract of rhodiola sachalinensis: brand number: PF005433, available from Sesamum indicum Biotechnology Co., ltd;
nepenthes extract: brand number: GNR 100TF, available from cantai biotechnology limited, guangzhou;
the extract of herba Chenopodii: brand number: GNR 100HA, available from the biotechnology company, huge, inc;
mung bean extract: brand number: abios 100, available from Guangzhou Hui Lang Biotechnology;
wild chrysanthemum extract: brand number: abios 200, available from Guangzhou Hui Lang Biotechnology;
peppermint extract: brand number: FL LS 9088, available from Shanghai Xie Rui, inc. Of industrial development;
kuh-seng root extract: brand number: PW LS 9852, available from Shanghai Xie Rui industrial development limited;
hedera helix extract: are commercially available;
dandelion extract: are commercially available;
buddleia extract: are commercially available;
kudzu extract: are commercially available;
extract of pica: are commercially available;
agastache rugosa extract: are commercially available;
nonwoven fabric: hydroentangled nonwoven fabrics, commercially available;
skin softening agent: mixing aloe extract with C12-15 alcohol benzoate according to a mass ratio of 3:2, and selling;
humectant: mixing glycerol and avocado oil according to a mass ratio of 18:5, and selling on the market;
antioxidant: p-hydroxyacetophenone, commercially available;
emulsifying agent: PEG-7 glycerol cocoate, commercially available;
preservative: chamomile extract, commercially available;
nutritional agent: vitamin E acetate, commercially available;
and (2) a surfactant: decyl glucoside and cocamidopropyl betaine are mixed according to the mass ratio of 3:2 and are commercially available;
pH regulator: triethanolamine, commercially available.
Examples 1 to 13 and comparative examples 1 to 21
The composition components of the antipruritic and anti-inflammatory compositions of examples a to C and comparative examples a to H of the present invention are shown in table 1.
TABLE 1
Comparative example I:21 parts of desmodium extract, 11 parts of rhodiola sachalinensis extract, 9 parts of nepenthes extract, 10 parts of hedera helix extract, 8 parts of mung bean extract, 16 parts of wild chrysanthemum extract, 12 parts of mint extract and 14 parts of radix sophorae flavescentis extract;
comparative example J:21 parts of desmodium extract, 11 parts of dandelion extract, 9 parts of nepenthes extract, 10 parts of ash vegetable extract, 8 parts of mung bean extract, 16 parts of wild chrysanthemum extract, 12 parts of mint extract and 14 parts of radix sophorae flavescentis extract;
comparative example K:21 parts of desmodium extract, 11 parts of rhodiola sachalinensis extract, 9 parts of nepenthes extract, 10 parts of ash grass extract, 8 parts of buddleia extract, 16 parts of kudzu extract, 12 parts of mint extract and 14 parts of potherb extract;
comparative example L:21 parts of desmodium extract, 11 parts of rhodiola sachalinensis extract, 9 parts of wrinkled gianthyssop extract, 10 parts of ash vegetable extract, 8 parts of mung bean extract, 16 parts of wild chrysanthemum flower extract, 12 parts of mint extract and 14 parts of radix sophorae flavescentis root extract.
The composition of the itching relieving and inflammation diminishing wet tissues of examples 1 to 13 and comparative examples 1 to 21 of the present invention are shown in Table 2.
The preparation methods of the itching relieving and inflammation diminishing wet tissues disclosed by the embodiments 1 to 13 and the comparative examples 1 to 21 comprise the following steps:
(1) Stirring a pH regulator and water for 3-5min at normal temperature to form a regulating solution;
(2) Stirring the skin softening agent, the humectant, the antioxidant, the emulsifier, the preservative, the nutrient, the surfactant and the water for 8-15min in a sealing way to obtain a first mixed material;
(3) Mixing the antipruritic and anti-inflammatory composition with the first mixed material, and sealing and stirring for 5-10min to obtain a second mixed material;
(4) Mixing the regulating solution with the second mixed material, supplementing water, and sealing and stirring for 5-10min to obtain antipruritic and antiinflammatory solution;
(5) Superposing the non-woven fabrics together, and then pouring the antipruritic and anti-inflammatory solution on the non-woven fabrics until the non-woven fabrics are completely absorbed;
the preparation method of the antipruritic and anti-inflammatory composition comprises the following steps:
(1) Weighing the eight-treasure rhodiola root extract, the mung bean extract, the wild chrysanthemum extract, the peppermint extract and the kuh-seng root extract according to parts by weight, and uniformly mixing at room temperature to obtain a mixture I;
(2) Cooling the mixture I to 10 ℃, adding the desmodium extract and the nepenthes extract according to parts by weight, and uniformly mixing; obtaining a mixture II;
(3) Placing the mixture II in a light-proof closed environment, adding herba Chenopodii chinensis extract, and mixing uniformly to obtain the antipruritic and antiinflammatory composition.
The preparation method of the itching relieving and inflammation diminishing wet tissues of comparative example 14 comprises the following steps:
(1) Stirring a pH regulator and water for 3-5min at normal temperature to form a regulating solution;
(2) Stirring the skin softening agent, the humectant, the antioxidant, the emulsifier, the preservative, the nutrient, the surfactant and the water for 8-15min in a sealing way to obtain a first mixed material;
(3) Mixing the antipruritic and anti-inflammatory composition with the first mixed material, and sealing and stirring for 5-10min to obtain a second mixed material;
(4) Mixing the regulating solution with the second mixed material, supplementing water, and sealing and stirring for 5-10min to obtain antipruritic and antiinflammatory solution;
(5) Superposing the non-woven fabrics together, and then pouring the antipruritic and anti-inflammatory solution on the non-woven fabrics until the non-woven fabrics are completely absorbed;
the preparation method of the antipruritic and anti-inflammatory composition comprises the following steps:
weighing herba lysimachiae extract, radix sophorae flavescentis extract, nepenthes extract, ash grass extract, mung bean extract, wild chrysanthemum extract, mint extract and radix sophorae flavescentis extract according to parts by weight, and uniformly mixing at room temperature to obtain the antipruritic and anti-inflammatory composition.
The preparation method of the itching relieving and inflammation diminishing wet tissues of the comparative example 15 comprises the following steps:
(1) Stirring a pH regulator and water for 3-5min at normal temperature to form a regulating solution;
(2) Stirring the skin softening agent, the humectant, the antioxidant, the emulsifier, the preservative, the nutrient, the surfactant and the water for 8-15min in a sealing way to obtain a first mixed material;
(3) Mixing the antipruritic and anti-inflammatory composition with the first mixed material, and sealing and stirring for 5-10min to obtain a second mixed material;
(4) Mixing the regulating solution with the second mixed material, supplementing water, and sealing and stirring for 5-10min to obtain antipruritic and antiinflammatory solution;
(5) Superposing the non-woven fabrics together, and then pouring the antipruritic and anti-inflammatory solution on the non-woven fabrics until the non-woven fabrics are completely absorbed;
the preparation method of the antipruritic and anti-inflammatory composition comprises the following steps:
weighing the eight-treasure rhodiola rosea extract, the mung bean extract, the wild chrysanthemum extract, the mint extract, the kuh-seng extract, the desmodium extract and the nepenthes extract according to parts by weight, uniformly mixing at room temperature, placing in a light-shielding closed environment, adding the ash vegetable extract, and uniformly mixing to obtain the itching-relieving and inflammation-diminishing composition.
TABLE 2
Effect example
The itching relieving and inflammation diminishing wet tissues prepared in the examples and the comparative examples are tested for performance, and specific test items and test methods are as follows:
(1) Antipruritic effect evaluation experiment: pure Kunming mice are selected, the body mass of the mice is 26-28 g,340 mice are randomly grouped, 10 mice in each group are respectively male and female, and the abdomen of the mice is dehaired. The itching relieving and anti-inflammatory wet tissues described in examples 1 to 13 and comparative examples 1 to 21 were covered on the dehaired sites, and after 40min of administration, the samples were removed, and 005 mL.10g (1.25 mgkg) of 0.025% low molecular weight dextran was intravenously injected into each mouse tail. The mice can generate paroxysmal skin itch after the dextran is injected into the tail vein, the paroxysmal skin itch is expressed as the head scratching by the front paws, the trunk scratching by the rear paws, the mouth biting each part and tail of the body, the accumulated duration of the paroxysmal skin itch of each group of mice within 30min is subjected to data statistics treatment, and the antipruritic effect of the drug is evaluated.
(2) Sterilization experiment: the detection is carried out according to the requirements of the 2002 edition of the Ministry of health, and the sterilization test is carried out on staphylococcus aureus, escherichia coli and candida albicans respectively.
(3) Antibacterial effective action time test: the duration of antibacterial effectiveness was tested according to the duration antibacterial experimental procedure in standard WS/T650-2019.
(4) Moisture retention test experiment: 340 volunteers were randomly selected and divided into 34 groups of 10 volunteers, and the ratio of dry skin, neutral skin and mixed skin in each group was about the same, and the itching relieving and inflammation diminishing wet tissues described in examples 1 to 13 and comparative examples 1 to 21 were rubbed respectively, and the skin moisture change of the hand skin of the volunteers before and after the application of the disinfectant hand sanitizer was measured by a skin moisture tester.
(5) And (3) testing the anti-inflammatory effect: pure Kunming mice are selected, the body mass of the mice is 26-28 g,340 mice are randomly grouped, 10 mice in each group are respectively half male and female, 0.05ml of dimethylbenzene is smeared on the front side and the back side of the left ear of the mice, and the right ear of the mice is used as a control. The itching relieving and inflammation diminishing wet tissues described in examples 1 to 13 and comparative examples 1 to 21 were covered on the front and rear sides of the left ear after 1 hour, the samples were removed after 2 hours of administration, the mice were sacrificed by dislocation, both ears were cut off along the auricle base line, round ears were respectively punched on the same site with a punch having a diameter of 8mm, and the antiphlogistic effect of the medicines was evaluated by the degree of swelling of the difference between the weights of the left and right pieces.
The results of the performance test of the itching relieving and anti-inflammatory wet tissues described in examples 1-13 and comparative examples 1-21 are shown in the table.
TABLE 3 Table 3
As is clear from examples 1-3 and comparative examples 16-17, as the amount of the antipruritic and anti-inflammatory composition added increases, the antibacterial property, the antibacterial effective time and the moisturizing property of the antipruritic and anti-inflammatory wet tissues increase and decrease, and the cumulative duration also decreases and increases. According to the data of examples 1, 4-7 and comparative examples 18-19, the antibacterial property, the antibacterial effective time and the antipruritic effect of the antipruritic and anti-inflammatory wet tissues are optimal when the mass percentage of the emulsifying agent in the antipruritic and anti-inflammatory wet tissues is 1.5-4.0% and the mass percentage of the surfactant is 0.5-1.3%. According to the data of examples 1, 8-11 and comparative examples 20-21, the anti-itch and anti-inflammatory wet tissues have the best antibacterial property, antibacterial effective time, moisturizing property and anti-itch effect when the mass percentage of the humectant in the anti-itch and anti-inflammatory wet tissues is 2.0-5.2% and the mass percentage of the antioxidant is 0.2-0.5%. From the data of example 1 and comparative examples 1-13, it can be seen that the wet tissues do not have antipruritic and antibacterial effects when no antipruritic anti-inflammatory composition is added to the wet tissues. When any component of the antipruritic and anti-inflammatory composition is absent, the antipruritic effect of the wet tissue is obviously reduced, and the antibacterial property is slightly reduced. From the data of example 1 and comparative examples 14 to 15, it is understood that the preparation process of the antipruritic and antiinflammatory composition also affects the antipruritic and antiinflammatory effects and antibacterial effects of the wet tissues prepared.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted equally without departing from the spirit and scope of the technical solution of the present invention.
Claims (7)
1. An antipruritic and anti-inflammatory composition is characterized by comprising the following components in parts by weight: 20-25 parts of desmodium extract, 11-16 parts of rhodiola sachalinensis extract, 9-14 parts of nepenthes extract, 8-15 parts of ash grass extract, 6-12 parts of mung bean extract, 15-25 parts of wild chrysanthemum extract, 11-19 parts of mint extract and 13-18 parts of radix sophorae flavescentis extract;
the preparation method of the antipruritic and anti-inflammatory composition comprises the following steps:
(1) Mixing radix Rhodiolae extract, semen Phaseoli Radiati extract, flos Chrysanthemi Indici extract, herba Menthae extract and radix Sophorae Flavescentis extract at room temperature to obtain mixture I;
(2) Cooling the mixture I to 5-15deg.C, adding herba Lysimachiae Christinae extract and herba Nepetae extract, and mixing; obtaining a mixture II;
(3) Placing the mixture II in a light-proof closed environment, adding herba Chenopodii chinensis extract, and mixing uniformly to obtain the antipruritic and antiinflammatory composition.
2. Use of an antipruritic and anti-inflammatory composition as defined in claim 1 for the preparation of an antipruritic and anti-inflammatory wet wipe.
3. The itching relieving and inflammation diminishing wet tissue is characterized by comprising the following components in percentage by mass: the antipruritic and anti-inflammatory composition according to claim 1, wherein the composition comprises 10-24% of an antipruritic and anti-inflammatory composition, 2.0-5.2% of a humectant, 0.2-0.5% of an antioxidant, 1.5-4.0% of an emulsifier, 0.5-1.3% of a surfactant, 20-35% of a nonwoven fabric, 0.3-0.9% of a skin softening agent, 0.03-0.9% of a preservative, 0.05-0.3% of a nutritional agent, 0.05-0.7% of a pH regulator, and the balance of water.
4. The itching relieving and inflammation diminishing wet tissue according to claim 3, wherein the humectant is at least one of glycerin, polymerized glycerin, xylitol glucoside, avocado oil, propylene glycol; the antioxidant is p-hydroxyacetophenone.
5. The itching relieving and inflammation diminishing wet tissue according to claim 3, wherein the surfactant is at least one of decyl glucoside, polysorbate 20, cocamidopropyl betaine; the emulsifier is PEG-7 glycerol cocoate.
6. The anti-itch and anti-inflammatory wet wipe according to claim 3, wherein said skin softening agent is at least one of aloe extract, PEG/PPG-14/7 dimethyl ether, C12-15 alcohol benzoate; the nutritional agent is vitamin E acetate; the antiseptic is at least one of cetyl pyridinium chloride, polychloropropyl biguanide, chlorpheniramine, benzoic acid, phenoxyethanol and flos Matricariae Chamomillae extract; the pH regulator is triethanolamine.
7. The method for preparing the itching relieving and inflammation diminishing wet tissues according to claim 3, which comprises the following steps:
(1) Stirring a pH regulator and water for 3-5min at normal temperature to form a regulating solution;
(2) Stirring the skin softening agent, the humectant, the antioxidant, the emulsifier, the preservative, the nutrient, the surfactant and the water for 8-15min in a sealing way to obtain a first mixed material;
(3) Mixing the antipruritic and anti-inflammatory composition with the first mixed material, and sealing and stirring for 5-10min to obtain a second mixed material;
(4) Mixing the regulating solution with the second mixed material, supplementing water, and sealing and stirring for 5-10min to obtain antipruritic and antiinflammatory solution;
(5) And superposing the non-woven fabrics together, and then pouring the antipruritic and anti-inflammatory solution on the non-woven fabrics until the non-woven fabrics are completely absorbed.
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| CN114146112A (en) * | 2020-09-07 | 2022-03-08 | 湖州新活医疗科技有限公司 | Traditional Chinese medicine composition for relieving swelling and itching or diminishing inflammation and relieving itching, preparation method and application thereof |
| CN113197836A (en) * | 2021-05-19 | 2021-08-03 | 广东添乐化妆品有限公司 | Moisturizing, relieving, itching-relieving and skin-protecting cream and preparation method thereof |
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