CN112494388A - Nonalcoholic spray for repelling mosquitoes and relieving itching and preparation method thereof - Google Patents
Nonalcoholic spray for repelling mosquitoes and relieving itching and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses nonalcoholic mosquito-repelling itching-relieving spray and a preparation method thereof. The mosquito-repellent itching-relieving spray comprises, by mass, 0.05-2% of lemon grass essential oil, 0.05-1.5% of argy wormwood leaf essential oil, 0.02-0.8% of calamus oil, 0.5-2% of wintergreen oil, 0.1-1% of borneol, 0.1-0.5% of menthol, 2-8% of dipropylene glycol, 2-5% of cyclodextrin or cyclodextrin derivative, 0.5-2% of licorice extract, 1-8% of butanediol, 0.2-1% of preservative and the balance of deionized water. The alcohol-free mosquito-repellent toilet water has mild effect, no toxic or side effect, safer and no stimulation in use, no side effect and no harm to the skin caused by ethanol under the condition of meeting the mosquito-repellent requirement, and is particularly suitable for children, women and people allergic to ethanol.
Description
Technical Field
The invention belongs to the technical field of daily chemical industry, and particularly relates to nonalcoholic mosquito-repelling itching-relieving spray and a preparation method thereof.
Background
In summer, in order to avoid mosquito bites, mosquito repellent toilet water is often applied to the body. Various toilet waters are available in the market at present, but the traditional raw materials of the toilet water are mosquito repellent ester, alcohol, menthol, borneol, thymol, camphor, essence, alcohol and deionized water, and the toilet water has the functions of cooling and removing miliaria and has little effect on insect dermatitis caused by mosquito bites. The effective component of most toilet water is mosquito repellent ester, for example, Chinese patent 03116972.4, mosquito repellent toilet water, and the raw material contains mosquito repellent ester, which is the main active component for repelling mosquito. The anophelifuge ester has certain toxicity, and can be absorbed by digestive tract and respiratory tract during application to induce asthma, and cause cancer and teratogenesis. Ethanol is added into a plurality of toilet water, such as Chinese patents 200910192803.0, 201020112216.9 and the like, when the mosquito repellent is used, the aim of repelling mosquitoes is achieved by means of volatilization of the ethanol, but the acting time is short, and many people are sensitive to the ethanol, especially children, old people and people allergic to the ethanol, so the application range of the mosquito repellent is greatly reduced.
At present, the functions of the toilet water are mainly divided into mosquito repelling and itching relieving, most of the commercially available toilet water has single function, and the effective time is short. How to organically combine the two to prepare the mosquito-repelling itching-relieving toilet water which is non-toxic and non-irritating to human bodies is a problem which needs to be solved urgently in the field of daily chemicals at present.
Disclosure of Invention
The invention aims to solve the defects of the prior art and provide the non-alcohol type mosquito-repelling and itching-relieving spray which does not contain deet, is non-toxic, harmless and non-irritant to a human body and integrates mosquito repelling and itching relieving.
The invention provides alcohol-free mosquito-repelling itching-relieving spray which comprises the following components in percentage by mass: 0.05-2% of lemon grass essential oil, 0.05-1.5% of argy wormwood leaf essential oil, 0.02-0.8% of calamus oil, 0.5-2% of wintergreen oil, 0.1-1% of borneol, 0.1-0.5% of menthol, 2-8% of dipropylene glycol, 2-5% of cyclodextrin or cyclodextrin derivative, 0.5-2% of licorice extract, 1-8% of butanediol, 0.2-1% of preservative and the balance of deionized water.
Preferably, the alcohol-free type mosquito-repelling and itching-relieving spray comprises the following components in percentage by mass: 0.5-2% of lemon grass essential oil, 0.5-1.5% of argy wormwood leaf essential oil, 0.5-0.8% of calamus oil, 0.5-2% of wintergreen oil, 0.5-1% of borneol, 0.3-0.5% of menthol, 4-6% of dipropylene glycol, 3-5% of cyclodextrin or cyclodextrin derivative, 0.5-2% of licorice extract, 3-5% of butanediol, 0.5-1% of preservative and the balance of deionized water.
More preferably, the non-alcohol type mosquito-repelling and itching-relieving spray comprises the following components in percentage by mass: 0.5-0.6% of lemon grass essential oil, 0.5-0.6% of argy wormwood leaf essential oil, 0.5-0.6% of calamus oil, 0.5-0.6% of wintergreen oil, 0.8-1% of borneol, 0.4-0.5% of menthol, 4-5% of dipropylene glycol, 4-5% of cyclodextrin or cyclodextrin derivative, 1-2% of licorice extract, 3-4% of butanediol, 0.5-0.6% of preservative and the balance of deionized water.
Wherein the preservative is phenoxyethanol.
The cyclodextrin or the cyclodextrin derivative is one or a mixture of more of alpha-cyclodextrin, alpha-cyclodextrin derivative, beta-cyclodextrin derivative, gamma-cyclodextrin and gamma-cyclodextrin derivative. Preferably, the cyclodextrin or cyclodextrin derivative is β -cyclodextrin.
The preparation method of the alcohol-free mosquito-repelling itching-relieving spray comprises the following steps:
s1, weighing dipropylene glycol, adding borneol and menthol, heating to dissolve, weighing cyclodextrin or cyclodextrin derivatives, adding lemongrass essential oil, folium artemisiae argyi essential oil, calamus oil and wintergreen oil, and stirring uniformly to obtain a solution A;
s2, weighing deionized water, butanediol and licorice extract, heating to 80 ℃, preserving heat for half an hour for sterilization, cooling to about 45 ℃, and adding the solution A under stirring;
s3, weighing, adding the preservative, and uniformly mixing to obtain the product.
Has the advantages that:
the non-alcohol type mosquito-repelling itching-relieving spray disclosed by the invention has the effects of repelling mosquitoes and relieving itching, does not contain deet, reduces the toxicity of deet to a human body, and does not contain ethanol which is irritant to the human body.
The mosquito repellent contains cyclodextrin or cyclodextrin derivatives, the cyclodextrin or cyclodextrin derivatives with good water solubility can wrap fat-soluble components, the stability is good, after the mosquito repellent is smeared on skin, the mosquito repellent is not greasy, the release of volatile mosquito repellent essential oil is slow, and the mosquito repellent effect is better. Replaces emulsification or solubilizer in a common alcohol-free formula, and avoids the defects of poor solution property, whitening after being applied to the skin, heavy greasy feeling and stuffiness.
The essential oil of herba Cymbopogonis Citrari, folium Artemisiae Argyi, rhizoma Acori Calami, and wintergreen oil have synergistic mosquito repellent effect, and the main ingredient glycyrrhizic acid of Glycyrrhrizae radix extract has antiinflammatory and itching relieving effects.
The solvent dipropylene glycol has good water, oil and hydrocarbon co-dissolving capacity, and has the advantages of slight smell, little irritation to skin and low toxicity.
The alcohol-free mosquito-repellent toilet water has mild effect, no toxic or side effect, safer and no stimulation in use, no side effect and no harm to the skin caused by ethanol under the condition of meeting the mosquito-repellent requirement, and is particularly suitable for children, women and people allergic to ethanol.
Detailed Description
The present invention is further illustrated by the following specific examples, which are provided for illustrative purposes only and do not limit the scope of the present invention in any way.
Lemon grass essential oil, argy wormwood leaf essential oil, calamus oil and wintergreen oil are all purchased from Jian city Roc natural perfume oil Co., Ltd, and the batch numbers are 20190123,20190514,20190404,20180516 respectively.
The licorice extract was purchased from Yili Queensland Biotech Ltd, Lot 20190606.
Example 1
The alcohol-free mosquito-repelling itching-relieving spray comprises the following components in percentage by mass: 1% of lemon grass essential oil, 1% of folium artemisiae argyi essential oil, 0.8% of calamus oil, 1% of wintergreen oil, 0.5% of borneol, 0.3% of menthol, 4% of dipropylene glycol, 3% of beta-cyclodextrin, 0.5% of liquorice extract, 3% of butanediol, 0.5% of phenoxyethanol and 84.4% of deionized water.
The preparation method comprises the following steps:
s1, weighing dipropylene glycol, adding borneol and menthol, heating to dissolve, weighing beta-cyclodextrin, adding lemongrass essential oil, folium artemisiae argyi essential oil, calamus oil and wintergreen oil, and stirring uniformly to obtain a solution A;
s2, weighing deionized water, butanediol and licorice extract, heating to 80 ℃, preserving heat for half an hour for sterilization, cooling to about 45 ℃, and adding the solution A under stirring;
s3, weighing, adding the preservative phenoxyethanol, and uniformly mixing to obtain the product.
Example 2
The alcohol-free mosquito-repelling itching-relieving spray comprises the following components in percentage by mass: 0.5% of lemon grass essential oil, 0.5% of argy wormwood leaf essential oil, 0.5% of calamus oil, 0.5% of wintergreen oil, 1% of borneol, 0.5% of menthol, 4% of dipropylene glycol, 5% of hydroxypropyl cyclodextrin, 2% of licorice extract, 3% of butanediol, 0.5% of phenoxyethanol and 82% of deionized water.
The preparation method comprises the following steps:
s1, weighing dipropylene glycol, adding borneol and menthol, heating to dissolve, weighing hydroxypropyl cyclodextrin, adding lemongrass essential oil, folium artemisiae argyi essential oil, calamus oil and wintergreen oil, and stirring uniformly to obtain a solution A;
s2, weighing deionized water, butanediol and licorice extract, heating to 80 ℃, preserving heat for half an hour for sterilization, cooling to about 45 ℃, and adding the solution A under stirring;
s3, weighing, adding the preservative phenoxyethanol, and uniformly mixing to obtain the product.
Example 3
The alcohol-free mosquito-repelling itching-relieving spray comprises the following components in percentage by mass: 2% of lemon grass essential oil, 1.5% of argy wormwood leaf essential oil, 0.8% of calamus oil, 2% of wintergreen oil, 1% of borneol, 0.5% of menthol, 4% of dipropylene glycol, 5% of gamma-cyclodextrin, 0.5% of licorice extract, 3% of butanediol, 0.5% of phenoxyethanol and 79.2% of deionized water.
The preparation method comprises the following steps:
s1, weighing dipropylene glycol, adding borneol and menthol, heating to dissolve, weighing gamma-cyclodextrin, adding lemongrass essential oil, folium artemisiae argyi essential oil, calamus oil and wintergreen oil, and stirring uniformly to obtain a solution A;
s2, weighing deionized water, butanediol and licorice extract, heating to 80 ℃, preserving heat for half an hour for sterilization, cooling to about 45 ℃, and adding the solution A under stirring;
s3, weighing, adding the preservative phenoxyethanol, and uniformly mixing to obtain the product.
Inspection of the finished products of examples 1-3
(1) And (3) odor inspection: sense organ, no pungent smell, fresh smell;
(2) test of mosquito repelling Effect
An attack force experiment: 300 female Aedes albopictus mosquitoes which do not suck blood 4 days after eclosion are placed in a mosquito cage with the length, the width and the height of 40cm, 30cm and 30 cm. The back of the hand of the test person was exposed to 4cm x 4cm of skin, with the remainder tightly shielded. The hands are put into the mosquito cage to stay for 2min, closely observed, the mosquitoes are found to stop falling, the arms are shaken to drive the mosquitoes before the mouth organ of the mosquitoes is penetrated into the skin, and the mosquitoes are marked as one tested insect stopping. More than 30 test persons who stop before and have the attack force recorded as qualified test insects, and the person and the cage mosquitoes can be subjected to a repelling test;
② repelling test: selected from 30 testers with qualified offensive power, divided into 3 groups (using the mosquito-repelling itching-relieving spray prepared in examples 1-3 respectively), and each of the two hands was drawn with a skin area of 5cm × 5cm on the back, and one hand was pressed at a rate of 1.5 μ L/cm2The dosage of the composition is uniformly coated. The skin was exposed at 4cm by 4cm, the rest was tightly shielded, and the other hand was blank. Smearing repellent product for 2h, putting hands into mosquito cage with qualified attack force for 2min, and observing whether there is mosquito coming before and stopping and sucking blood. And then testing once every 2h, and judging that the repellent product fails as long as one mosquito sucks blood in front. The effective protection time (h) of the repellent product was recorded.
Comparative formulation 1 is a certain brand of alcohol-containing mosquito repellent spray: (containing DEET 10%)
Comparative formulation 2 was: 1% of lemon grass essential oil, 1% of folium artemisiae argyi essential oil, 0.8% of calamus oil, 1% of wintergreen oil, 0.5% of borneol, 0.3% of menthol, 4% of dipropylene glycol, 0.5% of liquorice extract, 3% of butanediol, 0.5% of phenoxyethanol, 36.8% of deionized water and 50% of ethanol.
And (3) test results: the effective protection time for each mosquito repellent spray is shown in table 1.
TABLE 1 effective guard time test results
(3) Test of antibacterial Property
The detection method comprises the following steps: two kinds of bacteria, namely escherichia coli and staphylococcus aureus, are selected, and a bacteriostasis test is carried out according to GB15979-2002 appendix C4 (the treatment time is 2 minutes). The specific results are shown in table 2 below:
TABLE 2 antibacterial Property test results
As can be seen from the above table, compared with the common commercial floral water, the finished product of the invention has obvious bacteriostatic effect on escherichia coli and staphylococcus aureus.
And (3) comprehensive mosquito repelling quality and effect tests, wherein the embodiment 2 is the preferred embodiment of the invention.
The above is only a preferred embodiment of the present invention, and it should be noted that the above preferred embodiment should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit and scope of the invention, and these modifications and improvements should be considered within the scope of the invention.
Claims (7)
1. The alcohol-free type mosquito-repelling itching-relieving spray is characterized by comprising the following components in percentage by mass: 0.05-2% of lemon grass essential oil, 0.05-1.5% of argy wormwood leaf essential oil, 0.02-0.8% of calamus oil, 0.5-2% of wintergreen oil, 0.1-1% of borneol, 0.1-0.5% of menthol, 2-8% of dipropylene glycol, 2-5% of cyclodextrin or cyclodextrin derivative, 0.5-2% of licorice extract, 1-8% of butanediol, 0.2-1% of preservative and the balance of deionized water.
2. The alcohol-free mosquito-repelling itching-relieving spray according to claim 1, which comprises the following components in percentage by mass: 0.5-2% of lemon grass essential oil, 0.5-1.5% of argy wormwood leaf essential oil, 0.5-0.8% of calamus oil, 0.5-2% of wintergreen oil, 0.5-1% of borneol, 0.3-0.5% of menthol, 4-6% of dipropylene glycol, 3-5% of cyclodextrin or cyclodextrin derivative, 0.5-2% of licorice extract, 3-5% of butanediol, 0.5-1% of preservative and the balance of deionized water.
3. The alcohol-free mosquito-repelling itching-relieving spray according to claim 2, which is characterized by comprising the following components in percentage by mass: 0.5-0.6% of lemon grass essential oil, 0.5-0.6% of argy wormwood leaf essential oil, 0.5-0.6% of calamus oil, 0.5-0.6% of wintergreen oil, 0.8-1% of borneol, 0.4-0.5% of menthol, 4-5% of dipropylene glycol, 4-5% of cyclodextrin or cyclodextrin derivative, 1-2% of licorice extract, 3-4% of butanediol, 0.5-0.6% of preservative and the balance of deionized water.
4. The non-alcohol type mosquito-repellent itching-relieving spray according to any one of claims 1 to 3, wherein the preservative is phenoxyethanol.
5. The non-alcohol type mosquito-repellent itching-relieving spray according to any one of claims 1 to 3, wherein the cyclodextrin or the cyclodextrin derivative is one or a mixture of more of alpha-cyclodextrin, alpha-cyclodextrin derivative, beta-cyclodextrin derivative, gamma-cyclodextrin and gamma-cyclodextrin derivative.
6. The non-alcohol mosquito-repellent antipruritic spray according to any one of claims 1 to 3, wherein the cyclodextrin or cyclodextrin derivative is β -cyclodextrin.
7. The preparation method of the non-alcohol type mosquito-repellent itching-relieving spray according to claims 1 to 6, which is characterized by comprising the following steps:
s1, weighing dipropylene glycol, adding borneol and menthol, heating to dissolve, weighing cyclodextrin or cyclodextrin derivatives, adding lemongrass essential oil, folium artemisiae argyi essential oil, calamus oil and wintergreen oil, and stirring uniformly to obtain a solution A;
s2, weighing deionized water, butanediol and licorice extract, heating to 80 ℃, preserving heat for half an hour for sterilization, cooling to about 45 ℃, and adding the solution A under stirring;
s3, weighing, adding the preservative, and uniformly mixing to obtain the product.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113967266A (en) * | 2021-11-12 | 2022-01-25 | 北京斯瑞朗文生物科技有限公司 | N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound and preparation method and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105380858A (en) * | 2015-12-04 | 2016-03-09 | 武汉璟泓万方堂医药科技股份有限公司 | Mosquito-repelling, bacterium-inhibiting, and itch-relieving spraying agent |
CN109392956A (en) * | 2018-09-11 | 2019-03-01 | 罗卫雄 | Plant mosquitofugal oil |
CN110917050A (en) * | 2018-09-19 | 2020-03-27 | 费有贵 | Mosquito-repellent toilet water for infants |
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2020
- 2020-12-16 CN CN202011486703.1A patent/CN112494388A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105380858A (en) * | 2015-12-04 | 2016-03-09 | 武汉璟泓万方堂医药科技股份有限公司 | Mosquito-repelling, bacterium-inhibiting, and itch-relieving spraying agent |
CN109392956A (en) * | 2018-09-11 | 2019-03-01 | 罗卫雄 | Plant mosquitofugal oil |
CN110917050A (en) * | 2018-09-19 | 2020-03-27 | 费有贵 | Mosquito-repellent toilet water for infants |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113967266A (en) * | 2021-11-12 | 2022-01-25 | 北京斯瑞朗文生物科技有限公司 | N, N-diethyl-2-hydroxy-2-phenylacetamide cyclodextrin inclusion compound and preparation method and application thereof |
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Application publication date: 20210316 |