CN109833431A - A kind of bacteriostatic gel and preparation method thereof - Google Patents
A kind of bacteriostatic gel and preparation method thereof Download PDFInfo
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- CN109833431A CN109833431A CN201910311590.2A CN201910311590A CN109833431A CN 109833431 A CN109833431 A CN 109833431A CN 201910311590 A CN201910311590 A CN 201910311590A CN 109833431 A CN109833431 A CN 109833431A
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Abstract
The invention belongs to medical field of gel, specially a kind of bacteriostatic gel and preparation method thereof.The bacteriostatic gel includes following raw material: carbomer 0.3%-1.0%；Glycerol 0.5%-3.0%；Propylene glycol 0.1%-3.0%；Borneol 0.01%-1.0%；Triclosan 0.1%-0.5%；Ethyl alcohol 0.1%-1.0%；Peppermint oil 0.01%-1.0%；Birds nest extract 0.1%-1.0%；Safflower extract 0.1%-1.0%；Ginseng extract 0.1%-1.0%；Herba Dendrobii extract 0.1%-1.0%；Triethanolamine 0.1%-1.0%；Surplus is pure water.Present invention bacteriostatic gel as made from rational formula, by being combined a variety of bacteriostatic active ingredients, significant synergistic effect is obtained at antibacterial aspect, affected part germ can be dispelled, mitigate the feeling of itch even to be eliminated, enhances diseased region to germ resistivity and immunocompetence.
Description
Technical field
The invention belongs to medical gel preparation technical field, specially a kind of bacteriostatic gel and preparation method thereof.
Technical background
Skin disease is a kind of common multiple diseases, and disease incidence with higher has seriously affected the daily life of people
Living and work.Dermopathic many kinds of, the cause of disease is complicated, and is difficult to eradicate, and different degrees of worries are brought to patient.
Skin infection and cutaneous lesions can all lead to skin disease, and wherein skin disease caused by skin infection is more common.Skin
Skin infection is mainly caused by bacterium or fungi, such as staphylococcus aureus, Escherichia coli and Candida albicans etc..Therefore, skin
Generally using disinfection, antibacterial treatment method in dermopathic clinical treatment caused by skin infects.Existing disinfection and sterilization skin
In medicine, includes mainly disinfection and sterilization ingredient, killed by these effective sterilization components except bacterium in skin or fungi.It is bacterium, true
The generation of bacterium is normally due to personal resistance decline causes.Above-mentioned disinfection and sterilization dermic only kills the mushroom except invasion, and
Lesion can not be eradicated, therefore is easy to produce repeatedly.
Summary of the invention
The present invention is in view of the above-mentioned problems, provide a kind of bacteriostatic gel and preparation method thereof.The preparation of the bacteriostatic gel can solve
Bacteriostasis property difference and the problem big to patient's side effect in certainly current antibacterial product, can meet the needs of many patients.
In order to realize the above goal of the invention, the technical solution of the present invention is as follows:
A kind of bacteriostatic gel, the raw material including following mass percent: carbomer 0.3%-1.0%；Glycerol 0.5%-
3.0%；Propylene glycol 0.1%-3.0%；Borneol 0.01%-1.0%；Triclosan 0.1%-0.5%；Ethyl alcohol 0.1%-1.0%；It is thin
Lotus oil 0.01%-1.0%；Birds nest extract 0.1%-1.0%；Safflower extract 0.1%-1.0%；Ginseng extract 0.1%-
1.0%；Herba Dendrobii extract 0.1%-1.0%；Triethanolamine 0.1%-1.0%；Surplus is the sum of pure water, gross mass percentage composition
It is 100%.
Preferably, above-described bacteriostatic gel, the raw material including following mass percent: carbomer 0.60%；It is sweet
Oil 1.0%；Propylene glycol 0.6%；Borneol 0.01%；Triclosan 0.25%；Ethyl alcohol 0.5%；Peppermint oil 0.05%；Birds nest extract
0.5%；Safflower extract 0.1%；Ginseng extract 0.2%；Herba Dendrobii extract 0.2%；Triethanolamine 0.35%；Surplus is pure
Water, the sum of gross mass percentage composition are 100%.
The preparation method of bacteriostatic gel described above, comprising the following steps:
1) each raw material is weighed in proportion；
2) preparation of gel-type vehicle: carbomer being dissolved in pure water in proportion, stands overnight (12h), completely to its swelling,
Obtain corresponding gel-type vehicle；
3) glycerol, propylene glycol are added into gel-type vehicle and is sufficiently stirred, it is molten that borneol, peppermint oil are then added thereto
Liquid is sufficiently stirred birds nest extract, ginseng extract, safflower extract, Herba Dendrobii extract is added, it is molten to be eventually adding triclosan
Bacteriostatic gel is tentatively made in liquid；
4) it is eventually adding triethanolamine the pH value of bacteriostatic gel is adjusted, makes pH value 5.5~7.5 to get final
Bacteriostatic gel.
Each ingredient of the present invention is having the effect that in the present invention
Pure water is drinking water through hyoscine made from the way of distillation, ion-exchange, hyperfiltration or other suitable methods
Water, be free of any additive.It can be made using water purification equipment, water purification equipment is produced for meeting every profession and trade demand
The equipment of purified water is chiefly used in the industries such as medicine, biochemistry chemical industry, food, and whole system is all by SUS304L or SUS316L
All steel material is composed, and whole system uses ultraviolet sterilization or ozonization, when to production purified water
Bacterium is eliminated, and guarantees the sanitation degree of purified water.
Ethyl alcohol is a kind of organic matter, its aqueous solution has the smell of aroma, and slightly stimulates, and can be used to sterilize
Agent also commonly uses solvent of the ethyl alcohol as reaction, dissolve the organic matter for participating in reaction and inorganic matter can, increases contact area,
Improve reaction rate.It is convenient for the thawing of other materials in the present invention, promotes drug action.
Carbomer is the high molecular polymer of acrylic acid bonding allyl sucrose or pentaerythrite allyl ether, be it is a kind of very
Important rheology control agent, the carbomer after neutralization are outstanding gel-type vehicles, there is the important uses such as thickening, suspension, technique letter
Single, stability is good.It is widely used in lotion, cream, in gel, the present invention uses Carbopol 940, and water is solvent.
Its chemical name is glycerine for glycerol, and colourless, transparent, odorless, thick liquid is sweet, have hygroscopicity, flammable,
The characteristics such as low toxicity.The present invention can prevent pachylosis using glycerol, avoid pigementation, using effect is fine.
The viscosity and good hygroscopicity of propylene glycol, and it is nontoxic, thus be widely used as in food, medicine and cosmetics industry
Moisturizer, antifreeze, lubricant and solvent.
Triclosan is the high purity white crystals powder of micro- tool fragrance, is slightly soluble in water, and solubility is moderate in diluted alkaline,
There is higher solubility in many organic solvents, can be made into after being dissolved in water-soluble solvent or surfactant transparent dense
Contracting liquid product.Triclosan is a kind of broad spectrum antimicrobial agent, very strong to the rejection ability of bacterium, blue to causing infection or pathogenicity to be removed from office
Formula positive bacteria, fungi, yeast and virus etc. all have extensive killing and inhibiting effect.
Borneol also known as piece brain, orange slices, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain, borneol brain, Mei Bing etc. are dragons
The resin and volatile oil processed goods of brain savoury herb kapur extract the crystallization obtained, are near pure d-Bomeol.Dragon
Brain perfume (or spice) aiphyllium, is born in tropical rain forest, is distributed in south east asia.From the crack of kapur trunk, dry tree is taken
Rouge is processed.Or cut down trunk and branch, cut into pieces, distil through steam distillation, it is cooling after crystallization.Borneol
Effect and effect: antibacterial action can inhibit the growth of hog cholera vibrios, Escherichia coli, staphylococcus aureus；Inducing resuscitation of having one's ideas straightened out is made
With borneol acrid flavour is bitter, thoughts of returning home warp, fragrant odour, and Xin Xiang walks to alter, and keeps away bad odor, logical nine orifices；Analgesic and antisepsis, borneol are used for
Its irritation very little to sensory nerve ending of part；Heat-clearing promoting muscle growth functions, external application have clearing away heat to and alleviating pain, the work of antipruritic effect and promoting granulation
With；Swelling and pain relieving effect, has swelling and pain relieving for the diseases external application such as sore scabies, aphtha, laryngalgia and eye illness, and has anti-corrosion, antipruritic
The benefits of.
Peppermint oil is colourless supernatant liquid, there is special refrigerant fragrance, is peppermint by being extracted in the leaf and stem of peppermint
Main component；Contain menthol in peppermint oil, has the function of anti-inflammatory analgetic.For the skin that bite by mosquitos is crossed have desensitization,
The effect of anti-inflammatory and antibacterial, while also playing the role of swelling and pain relieving, antiphlogistic antibacterial to hemorrhoid, anal fissure.Using peppermint oil to human body
Harm it is small, it is smaller to the injury of human body when smearing medicine to skin.
Birds nest extract: humoral immunity and cellular immunity can be enhanced.Bird's nest contains epidermal growth factor and promotes cell
The hormone of division can promote the growth and proliferation of cell, the also immune function to enhance human body；There are also beautifying face and moistering lotion works for bird's nest
Contain Sialic acid with, bird's nest, long-term consumption bird's nest can increase vivo acid and synthesis collagen, can improve skin because
It caused by aging the problems such as color spot, effectively lightens the stain, skin whitening；The regeneration function of epidermal growth factor in bird's nest to cell
There can be good effect with repair function, the division growth of cell can be stimulated, promote the differentiation of cell, can be repaired impaired
Skin, therefore skin can be made to become smooth exquisiteness, high resilience.
Safflower extract: there is whitening spot-removing effect, and can dye for cosmetics such as lipstick, kermes.
Ginseng extract: nti-freckle reduces wrinkle, activating skin cells, enhancing skin elasticity.Head can be improved in shampoo
The toughness of hair reduces alopecia, and break hair, has protective effect to the hair of damage.
Herba Dendrobii extract: HERBA DENDROBII orchid can significantly improve superoxides discrimination China enzyme level, reduce lipid peroxide, adjust
Brain monoaminergic transmitters are horizontal, inhibit similar monoamine oxidase, improve immunity, play the role of anti-aging.Golden hairpin stone
Dry measure used in former times orchid contains lactone component, has activating microcirculation and removing stasis medicinal, expansion blood vessel and antiplatelet condensation, treatment embolic occlusion pulse tube is scorching, brain
The effects of thrombosis, arteriosclerotic obliteration；The luxuriant and rich with fragrance class and bibenzyl substance extracted in HERBA DENDROBII orchid, there is anti-lung cancer, ovum
The effect of nest gland cancer and promyelocitic leukemia.T cell growth and lymphocyte can be promoted to generate inhibiting factor, enhancing is played and exempt from
The effect of epidemic disease.
Compared with prior art, the invention has the benefit that
(1), the bacteriostatic gel as made from rational formula is taken by being combined a variety of bacteriostatic active ingredients at antibacterial aspect
It obtains and significantly acts synergistically, affected part germ can be dispelled, mitigate the feeling of itch and even be eliminated, enhance diseased region pair
Germ resistivity and immunocompetence.
(2), this gel prevents dry skin, pigementation, the protection mainly formed after gel smearing in use
Film can effectively store up the moisture for staying skin surface, keep skin relatively wet, and the sensitivity of skin caused by avoiding because of the cold and hot temperature difference is anti-
It answers.Glycerol, propylene glycol also play the effect of moisturizing simultaneously, do not have toxic side effect to human body, use is safe.
(3), enviromental allergen is isolated in the protective film that gel is formed after smearing, and reduces the sensitizer in air to scar
Local stimulation.
(4), the freshener in gel can effectively pacify C class nerve fibre, play the role of refrigerant, town and itch.
(5), bacteriostatic gel provided by the invention, pH value is between 5.5~7.5, with normal human skin surface sebum film pH
Be worth similar, weakly acidic product is more beneficial to skin, at human body injury advantageously.
(6), gel of the invention has the function of promoting infiltration, skin its to good absorption effect, and the work of a variety of cosolvents
It ensure that the transparency of the appearance of gel, appearance are easier to receive under.
Specific embodiment
In order to make the contents of the present invention easily facilitate understanding, below in conjunction with specific embodiment to heretofore described
Technique is further elaborated.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiments.
Solutions of mint oil used in this application refers to the solution formed after peppermint oil is dissolved into ethyl alcohol；Peppermint oil and second
The mass ratio of alcohol is 1:1.All raw materials employed in the application are commercial product.
Embodiment 1:
A kind of bacteriostatic gel, the raw material including following mass percent: carbomer 0.60%；Glycerol 1.0%；Propylene glycol:
0.6%；Borneol: 0.01%；Triclosan: 0.25%；Ethyl alcohol 0.5%；Peppermint oil 0.05%；Birds nest extract 0.5%；Safflower mentions
Take object 0.1%；Ginseng extract 0.2%；Herba Dendrobii extract 0.2%；Triethanolamine 0.35%；Surplus is pure water, gross mass hundred
Dividing the sum of content is 100%.
The preparation method of above-mentioned bacteriostatic gel the following steps are included:
1) each component is weighed according to specified mass percent；
2) for the preparation of gel-type vehicle: carbomer being dissolved in pure water in proportion, stands overnight (12h), to its swelling
Completely, corresponding gel-type vehicle is obtained；
3) glycerol, propylene glycol are added into gel-type vehicle and is sufficiently stirred, borneol then is added thereto and peppermint oil is molten
Liquid is sufficiently stirred birds nest extract, ginseng extract, safflower extract, Herba Dendrobii extract is added, it is molten to be eventually adding triclosan
Bacteriostatic gel is tentatively made in liquid；
4) pH value for being eventually adding triethanolamine adjustment bacteriostatic gel is 5.8 to get final bacteriostatic gel.
Embodiment 2:
A kind of bacteriostatic gel, the raw material including following mass percent: carbomer 0.60%；Glycerol 1.0%；Propylene glycol
0.6%；Borneol 0.01%；Triclosan 0.20%；Ethyl alcohol 0.5%；Peppermint oil 0.05%；Birds nest extract 0.5%；Safflower extracts
Object 0.1%；Ginseng extract 0.2%；Herba Dendrobii extract 0.2%；Triethanolamine 0.35%；Surplus is pure water, gross mass percentage
The sum of content is 100%.
The preparation method is the same as that of Example 1 for bacteriostatic gel in the present embodiment, wherein adjusting bacteriostatic gel using triethanolamine
PH value is 5.8.
Embodiment 3:
A kind of bacteriostatic gel, the raw material including following mass percent: carbomer 0.60%；Glycerol 1.0%；Propylene glycol
0.6%；Borneol 0.01%；Triclosan 0.30%；Ethyl alcohol 0.5%；Peppermint oil 0.05%；Birds nest extract 0.5%；Safflower extracts
Object 0.1%；Ginseng extract 0.2%；Herba Dendrobii extract 0.2%；Triethanolamine 0.35%；Surplus is pure water, gross mass percentage
The sum of content is 100%.
The preparation method is the same as that of Example 1 for the bacteriostatic gel of the present embodiment, wherein adjusting bacteriostatic gel using triethanolamine
PH value is 5.8.
Comparative example 1:
A kind of bacteriostatic gel, the raw material including following mass percent: carbomer 0.60%；Glycerol 1.0%；Propylene glycol
0.6%；Borneol 0.01%；Lysozyme 0.50%；Ethyl alcohol 0.5%；Peppermint oil 0.05%；Birds nest extract 0.5%；Safflower extracts
Object 0.1%；Ginseng extract 0.2%；Herba Dendrobii extract 0.2%；Triethanolamine 0.35%；Surplus is pure water, gross mass percentage
The sum of content is 100%.
The preparation method is the same as that of Example 1 for the bacteriostatic gel of the present embodiment, wherein adjusting bacteriostatic gel using triethanolamine
PH value is 5.8.
Comparative example 2:
A kind of bacteriostatic gel, the raw material including following mass percent: carbomer 0.60%；Glycerol 1.0%；Propylene glycol
0.6%；Borneol 0.01%；Acetic acid chlorhexidine 0.1%；Ethyl alcohol 0.5%；Peppermint oil 0.05%；Birds nest extract 0.5%；Safflower
Extract 0.1%；Ginseng extract 0.2%；Herba Dendrobii extract 0.2%；Triethanolamine 0.35%；Surplus is pure water, gross mass
The sum of percentage composition is 100%.
The preparation method is the same as that of Example 1 for the bacteriostatic gel of the present embodiment, wherein adjusting bacteriostatic gel using triethanolamine
PH value is 5.8.
Comparative example 3:
A kind of bacteriostatic gel, the raw material including following mass percent: carbomer 0.60%；Glycerol 1.0%；Propylene glycol
0.6%；Borneol 0.01%；Triclosan 0.25%；Ethyl alcohol 0.5%；Peppermint oil 0.05%；Birds nest extract 0.5%；Safflower extracts
Object 0.1%；Herba Dendrobii extract 0.2%；Triethanolamine 0.35%；Surplus is pure water, and the sum of gross mass percentage composition is 100%.
The preparation method is the same as that of Example 1 for the bacteriostatic gel of the present embodiment, wherein adjusting bacteriostatic gel using triethanolamine
PH value is 5.8.
Comparative example 4:
A kind of bacteriostatic gel, the raw material including following mass percent: carbomer 0.60%；Glycerol 1.0%；Propylene glycol
0.6%；Borneol 0.01%；Ethyl alcohol 0.5%；Triclosan: 0.25%；Birds nest extract 0.5%；Safflower extract 0.1%；Ginseng
Extract 0.2%；Herba Dendrobii extract 0.2%；Triethanolamine 0.35%；Surplus is pure water, and the sum of gross mass percentage composition is
100%.
The preparation method is the same as that of Example 1 for the bacteriostatic gel of the present embodiment, wherein adjusting bacteriostatic gel using triethanolamine
PH value is 5.8.
Test one: antibacterial ring test is carried out to bacteriostatic gel prepared by the present invention.
One, material
1. test specimen: the bacteriostatic gel of embodiment 1-3, comparative example 1-4 preparation is verified
2. experiment equipment
(1) experimental strain staphylococcus aureus (CMCC (B) 26003), Escherichia coli (CMCC (B) 44102), white are read
Pearl bacterium (CMCC (F) 98001) bacteria suspension；
(2) stripping property resist (suppression) bacterium product, can be directly prepared into diameter be 5mm, thickness no more than 4mm disk (block), every 4
Piece (block) is one group；
(3) equipment needed for viable bacteria culture counts；
(4) vernier caliper；
(5) tryptose soya agar culture medium, Sabouraud dextrose fluid nutrient medium, pancreas peptone soybean broth culture medium
With Sabouraud glucose agar.
3. environmental condition: Chengdu Biao Hui detection technique Co., Ltd, D grades of clean areas, ten thousand grades of superclean benches, temperature 18-
26 DEG C, relative humidity 45-65%.
Two, method
1. detecting foundation: " disinfection technology standard " (version in 2008) 2.7.2 antibacterial ring tests.
2. test procedure: (1) stripping property resists (suppression) bacterium product, and can be directly prepared into diameter is 5mm, and thickness is no more than 4mm disk
(block), one group of every 4 (blocks).
(2) stripping property resists the negative control sample of (suppression) bacterium product, and material of the same race should be taken to be free of the sample of antibacterial composition, system
At print (block) identical with test group size.
(3) inoculation of test organisms: dipping concentration with sterile cotton swab is 5 × 105Cfu/mL~5 × 106Cfu/mL test organisms
Suspension is uniformly smeared 3 times on suitable culture medium flat plate surface.It is every smear 1 time, plate should rotate 60 °, finally by cotton swab around
Plate edge is smeared one week.Plate is covered, drying at room temperature 5min is set.
(4) bacteriostatic agent print is placed with: test is placed with 1 microbiological contamination plate every time, and each plate is placed with 4 test prints, and 1
Negative control print, totally 5.It is placed with aseptic nipper coupongs in planar surface.At a distance of 25mm or more between each print center,
Periphery with plate is at a distance of 15mm or more.After being placed with, with the light pressure-like piece of aseptic nipper, it is made to be tightly attached to planar surface.It covers
Plate, sets 37 DEG C of constant incubators, and culture 16h~18h observes result.With the diameter of vernier caliper measurement antibacterial ring size (including patch
Piece) and record.
(5) test is repeated 3 times.
(6) it when measuring antibacterial ring size, should select uniformly and the antibacterial ring size progress of integral asepsis growth.Measuring its diameter should be with antibacterial
Ring outer is boundary.
Three, result
Experimental group and control group bacteriostasis circle test result see the table below.
Table 1: performance test data table
From the point of view of 1 result of table, bacteriostatic gel prepared by the present invention is inhibiting Escherichia coli, golden yellow staphylococcus, white thought
In terms of the effect of pearl bacterium, there is antibacterial high-efficient and safe and non-stimulating, enhancing user relative to antibacterial product on the market
The advantages of compliance.
Test two: vaginal mucomembranous irritant test is carried out to bacteriostatic gel prepared by the present invention.
One, material and animal
1. test specimen: bacteriostatic gel prepared by embodiment 1
2. experimental animal: common rabbit 4 is provided, production licence number by farm, experimental animal special commission, Sichuan Province:
SCXK (river) 2013-14.
3. environmental condition: Sichuan Bio-pharmaceutical Industry Institute for Research and Technology experimental animal room uses credit number: SYXK (river)
2015-199,20-25 DEG C of temperature, relative humidity 50-70%.Rabbit feed is tested Company of Animals Ltd. up to rich fruit by Chengdu and is provided, raw
Produce credit number: SCXK (river) 2014-28.
Two, method
1. detecting foundation: " disinfection technology standard " (version in 2002) 2.3.5 vaginal mucomembranous irritant tests.
2. test procedure: 4 experimental rabbits are randomly divided into experimental group and control group, every group 2.Each animal is checked before experiment
Whether there is or not secretion, hyperemia and other degree of impairment for introitus, and blunt nosed hose (conduit) is connected with the syringe of 5ml.Experimental rabbit
Face upward fixation, exposure perineum and introitus, by conduit with by test solution it is wet after be gently inserted into vagina 4cm-5cm, and with injecting
Device is slowly injected into 2ml by test solution, gently withdrawal conduit.Control group does same processing with physiological saline.Use aeroembolism method afterwards for 24 hours
Animal is put to death, takes out complete vagina, and longitudinally slit, whether have the naked eyes lesion such as bleeding, oedema, choose vagina if being visually observed
Both ends and intermediate three positions carry out routine paraffin wax embedding and slice and carry out pathological study after HE dyeing.According to disease
Inspection result is managed, is scored the stimulate the reaction of vagina mucosa, is calculated the average integral of the stimulate the reaction of vagina mucosa, acquire
Stimulus index carries out stimulus intensity classification.
Three, result
Experimental group and control animals vagina are showed no the obvious naked eyes pathological change such as hyperemia, oedema, histopathology inspection
Looking into see the table below.It is 1.56 that test group vaginal mucosa irritation, which reacts average integral, and control group average integral is 1.0, vagina mucosa thorn
Swashing index is 0.56.
The reaction scoring of bacteriostatic gel vaginal mucosa irritation
Four, conclusion
The suppression prepared according to " disinfection technology standard " (version in 2002) vaginal mucosa irritation strength grading standard, embodiment 1
Bacterium gel is nonirritant to vagina mucosa.
It is elaborated although the present invention has passed through specific embodiment, this profession ordinary skill
Personnel should be understood that made on this basis without departing from any form of claims and the variation of details,
Belong to invention which is intended to be protected.
Claims (4)
1. a kind of bacteriostatic gel, it is characterised in that the bacteriostatic gel includes the raw material of following mass percent: carbomer 0.3%-
1.0%；Glycerol 0.5%-3.0%；Propylene glycol 0.1%-3.0%；Borneol 0.01%-1.0%；Triclosan 0.1%-0.5%；Ethyl alcohol 0.1%-
1.0%；Peppermint oil 0.01%-1.0%；Birds nest extract 0.1%-1.0%；Safflower extract 0.1%-1.0%；Ginseng extract 0.1%-
1.0%；Herba Dendrobii extract 0.1%-1.0%；Triethanolamine 0.1%-1.0%；Surplus is pure water, and the sum of gross mass percentage composition is
100%。
2. the bacteriostatic gel as described in claim 1, it is characterised in that the bacteriostatic gel includes the original of following mass percent
Material: carbomer 0.60%；Glycerol 1.0%；Propylene glycol 0.6%；Borneol 0.01%；Triclosan 0.25%；Ethyl alcohol 0.5%；Peppermint oil
0.05%；Birds nest extract 0.5%；Safflower extract 0.1%；Ginseng extract 0.2%；Herba Dendrobii extract 0.2%；Triethanolamine
0.35%；Surplus is pure water, and the sum of gross mass percentage composition is 100%.
3. the preparation method of bacteriostatic gel as described in claim 1 or claim 2, it is characterised in that the following steps are included:
1) by than weighing each raw material；
2) it prepares gel-type vehicle: carbomer is dissolved in pure water, stand overnight, to its complete swelling, obtain gel-type vehicle；
3) glycerol, propylene glycol are added in the gel-type vehicle being prepared into step 2, sufficiently, ice is then added in stirring thereto
Piece and solutions of mint oil are sufficiently stirred after adding birds nest extract, ginseng extract, safflower extract and Herba Dendrobii extract
It mixes, is eventually adding Triclosan solution, obtain preliminary bacteriostatic gel；
4) triethanolamine is added in the preliminary bacteriostatic gel being prepared into step 3) and adjusts pH value to get bacteriostatic gel.
4. the method as described in claim 3, it is characterised in that: adjusted in the step 4) pH value to 5.5~
7.5。
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112999339A (en) * | 2019-12-19 | 2021-06-22 | 陕西康乐实业有限公司 | Lysozyme gel and preparation method and application thereof |
| CN113396904A (en) * | 2021-06-21 | 2021-09-17 | 福州大学 | Preparation method of borneol-triclosan composite antibacterial agent |
| CN114452360A (en) * | 2022-03-24 | 2022-05-10 | 广东景兴健康护理实业股份有限公司 | Repairing and nourishing gel for cubilose and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112999339A (en) * | 2019-12-19 | 2021-06-22 | 陕西康乐实业有限公司 | Lysozyme gel and preparation method and application thereof |
| CN113396904A (en) * | 2021-06-21 | 2021-09-17 | 福州大学 | Preparation method of borneol-triclosan composite antibacterial agent |
| CN113396904B (en) * | 2021-06-21 | 2022-06-21 | 福州大学 | Preparation method of borneol-triclosan composite antibacterial agent |
| CN114452360A (en) * | 2022-03-24 | 2022-05-10 | 广东景兴健康护理实业股份有限公司 | Repairing and nourishing gel for cubilose and preparation method thereof |
| CN114452360B (en) * | 2022-03-24 | 2023-09-12 | 广东景兴健康护理实业股份有限公司 | Small-rain bird nest repairing and nourishing gel and preparation method thereof |
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