CN109260054A - A kind of plant mosquito-repellent antipruritic cream and preparation method thereof - Google Patents
A kind of plant mosquito-repellent antipruritic cream and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of plant mosquito-repellent antipruritic cream and preparation method thereof, the plant mosquito-repellent antipruritic cream includes anophelifuge activity ingredient and antipruritic active ingredients, the anophelifuge activity ingredient includes menthol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, oil of geranium and lavender oil, and the antipruritic active ingredients include C10-30 acid cholesterine/lanosterol mixed ester, Atlantic Ocean helmet chest porgy oil, camellia seed oil, Butyrospermum parkii fruit rouge, redwood seed oil, tocopherol and bisabolol.The present invention all uses plant mosquito component, the mosquito repellent component of no pesticide formula；And a variety of organic natural components of addition, ingredient is mild, and ointment shape is made, and it is at low cost, it is of the invention to use anophelifuge activity ingredient and antipruritic active ingredients collocation, can have mosquito repellent, antipruritic double effects, there is good effect to treatment insect dermatitis.
Description
Technical field
The present invention relates to technical field of daily necessities, it is specifically related to a kind of plant mosquito-repellent antipruritic cream and preparation method thereof.
Background technique
Common people after mosquito bite, can all be occurred it is red and swollen, itch, the symptoms such as pain.It there is also sometimes after mosquito bite
Red and swollen surprise is itched.It should avoid excessively scratching grabbing, otherwise be particularly easy to infect, scratch the tissue fluid that can also stimulate in skin, leaching
The exudation of bar liquid, part not only can be red and swollen, and itches more grabbing, especially allergic skin, it is also possible to the more scratch the more serious, be formed large stretch of
Red and swollen mosquito when sucking blood, is also injected into saliva by its point but also thin mouth bites human skin not only, thus can spread the disease, such as
Malaria, filariasis, Japanese Type-B encephalitis etc..Therefore, the product of mosquito repellent is also many on the market at present, and it is tired to release mosquito for people
It disturbs and provides very big help.But the ingredient that can be good at playing mosquito-repelling function in popular mosquito repellent product a few days ago mainly keeps away mosquito
Amine (DEET), chemical name are diethyltoluamide, have good mosquito-repelling function, are a kind of widely used insecticides.
But Britain " BMC biology " magazine result of study shows a kind of key enzyme acetylcholine ester in Metadelphene Central nervous system
The activity of enzyme has inhibiting effect, and this enzyme is all very crucial in the central nervous system of insect and mammal, it is necessary to
Again the safety of this culicifuge is furtherd investigate.So developing various do not contain for the consideration to public health safety and keeping away
The mosquito repellent product of mosquito amine is of great value.
Summary of the invention
It is an object of the invention to overcome the above problem and provide a kind of plant mosquito-repellent antipruritic cream and preparation method thereof, with solution
The problem of possibility potentially danger that certainly current mosquito repellent product itching-relieving action is insufficient, chemicals uses, and there is certain nourishing flesh
Skin effect, performance is mild, has both the plant mosquito-repellent antipruritic cream of mosquito repellent and antipruritic double effects.
To achieve the above object, the technical solution adopted by the present invention is that a kind of plant mosquito-repellent antipruritic cream, including anophelifuge activity
Ingredient, the anophelifuge activity ingredient include menthol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, Pelargonium roseum
Oil and lavender oil, each ingredient parts by weight shared by plant mosquito-repellent antipruritic cream in the anophelifuge activity ingredient are by following
Meter: 0.1~5 part of menthol, 0.01~3 part of Eucalyptus Globulus oil, 0.01~2 part of Blumea oil, 0.01~2 part of citronella grass oil, spearmint leaf
0.01~2 part of oil, 0.01~2 part of oil of geranium and 0.01~2 part of lavender oil.
Menthol has the function of excited brain, promotes blood circulation, anti-inflammatory analgetic, anti-itch detoxification and dispelling wind and heat from the body.Its
Cheongju cool incense gas, can also gentle nervous indignation mood, spirit can be improved, body and mind joy, help is made to fall asleep.
Eucalyptus oil is to extract essential oil from the leaf, branch of blue gum, folium eucalypti tree, cinnamomum camphora tree and camphor tree etc. with steam distillation,
Mainly contain 1,8- Cineole (80% or more), amphene, phellandrene, terpinol, geranyl alcohol, isopentyl aldehyde, citronellal and Hu
Green pepper ketone, can refrigerant body, analgesic, antibacterial, and inflammation symptom can be alleviated.
Blumea oil is contained volatile oil in the cured leaf or fresh leaf of compositae plant Chinese mugwort, and principle active component is Pu Pin enol -4
With α-terpinenol.It is double to bacillus anthracis, Alpha-hemolytic streptococcus, B- Streptococcus hemolyticus, corynebacterium diphtheriae, bacillus pseudodiphthericus, lung class
10 kinds of thermophilic gas of Gram-positive such as coccus, staphylococcus aureus, Staphylococcus citreus, staphylococcus aureus, hay bacillus
Bacterium all has antibacterial action；Meanwhile there is mosquito repellent function.
Citronella grass oil: citronella oil be also known as vanilla flavour concentrate or citronella oil, by the herb of lemongrass through steam distillation and it is faint yellow
It is citronellal, geraniol and citronellol that liquid, which has strong Chinese pepper fragrance main component,.For extracting citronellal, for synthesizing hydroxyl
Base citronellal, geraniol and menthol.It also is used as insecticide, anophelifuge and soap perfume.
Spearmint leaf oil: main component is fragrant non-irrigated spearmint celery seed oil mushroom ketone (content 60-65%), furthermore also there is lemon
Hydrocarbon, Chinese celery sesame oil hydrocarbon etc., are mainly used to candy, toothpaste fragrance, also for pharmaceutical.Leaf, spray or herb are also used as medicine, and cure cold hair
Heat, cough, cough due to consumptive disease, cold, headache, pharyngalgia, nervous headache, flatulence, bruise stasis caused pain, the peppery pain of hot eyes, nose
Nosebleed, crow treatment, total numbness and children's boil.
Oil of geranium: Pelargonium roseum can extract oil of geranium because stem, leaf and Huadu contain volatile aroma,
Its main component is geraniol, rhodinol, citronellol, linalool etc., can make the substitute of attar of rose, to modulate essence, perfume (or spice)
Water makees the additive of edible oil, perfumed soap and toothpaste etc., becomes one of the important source material of perfume industry because its sesame oil content is high, this
Application has good repelling effect inventors have found that oil of geranium is compounded with other plant oil.
Lavender oil: lavender is known as " after vanilla ", is suitble to any skin, promotes cytothesis, accelerating wound healing,
Its fragrance energy refreshment eyesight improving, makes one comfortable, moreover it is possible to repel mosquitoes and flies.It is having with camellia seed oil extraction lavender that lavender, which impregnates oil,
Imitate ingredient.Lavender, which impregnates oil, can inhibit the growth of bacterium, avoid causing skin infection, pacify skin, balance skin grease point
It secretes excessively, analgesic anti-melancholy, is sterilized, sterilized, decongest swelling and expelling parasite, calming and get well.Be suitable for any skin,
Treatment burns, tans severely, and promotes cytothesis, balance sebum secretion；Improve acne, abscess, eczema；It prevents bald；Sterilization expelling parasite,
Clearing liver, spleen promote functions of intestines and stomach, anti-nausea, improve physiological problem；Improve bronchitis, asthma, laryngitis；Stable mood resists and prevents
Funeral, controls insomnia at blood pressure lowering.
The present invention is with menthol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, oil of geranium and lavender
Oil is anophelifuge activity ingredient, and these types of ingredient is carried out compounding by discovery has good repelling effect, and carries out with antipruritic ingredient
Collocation use can also enhance antipruritic effect.
Preferably, each ingredient parts by weight shared by plant mosquito-repellent antipruritic cream in the anophelifuge activity ingredient are by following
Meter: 1~1.8 part of menthol, 0.8~1.4 part of Eucalyptus Globulus oil, 0.4~0.8 part of Blumea oil, 0.4~0.8 part of citronella grass oil, spearmint
0.2~0.6 part of leaf oil, 0.1~0.6 part and 0.3~0.7 part of lavender oil of oil of geranium.Anophelifuge activity ingredient of the present invention
In, the proportion of component will affect effect, the study found that within the scope of the preferred parts by weight, plant mosquito-repellent antipruritic of the present invention
The repelling effect of cream is more preferably.
It preferably, further include antipruritic active ingredients, the antipruritic active ingredients include C10-30 acid cholesterine/lanosterol
Mixed ester, Atlantic Ocean helmet chest porgy oil, camellia seed oil, Butyrospermum parkii fruit rouge, redwood seed oil, tocopherol and bisabolol.
C10-30 acid cholesterine/lanosterol mixed ester is by being largely saturated the fatty acid, fatty alcohol and steroid of branched structure
Alcohol is constituted, and structure is similar to the sebum of human skin: being facilitated moisture penetration epidermis, is penetrated into skin corium, keeps growing for skin
Profit；Softening skin, the moment keep water profit, play it is tender, healthy；One layer of waterproof, rich glossiness barrier are formed in skin surface；It repairs
Dry and cracked skin.
Atlantic Ocean helmet chest porgy oil: in the long-lived fish of 800~1500 meters of deep-sea growth of New Zealand, from fish-skin and physical feeling
The obtained raw oil extracted solves the fishy smell and discoloration problem of fish oil after height dehydrogenation, decoloration, selective hydrogenation processing,
Almost colourless tasteless deep sea fish oil is obtained, fish oil is similar with human skin lipid layer composition, has good compatibility, to light
Spend Atopic dermatitis, drying property sensitivity flesh has outstanding healing effect.Skin-friendly is good, and skin easily absorbs.Good stability, no
It is easily rancid.Efficient antiallergic, anti-inflammatory, freeze proof, potent moisturizing, moisten smooth skin, especially suitable for sensibility symptom, xerosis
Shape, scales of skin that peel off symptom, pruritis skin.
Camellia seed oil: camellia is most notable one of Theaceae species.The also referred to as rose in winter.It is that one kind is opened
Colored dungarunga, originates in South Korea and Japan.The plant is usually claimed " Dongbaek " in South Korea, is commonly known as in Japan
"Tsubaki".It is to be grown in one of protophyte of Jizhou Island.Camellia oil inhibits NO, PGE2, the pro-inflammatory mediators such as TNF-α
It generates, furthermore camellia oil reduces the expression of NOS and COX-2 gene to inhibit NF- κ B and AP-1 signal path.1. anti-wrinkle effect:
Improve the generation of collagen；2. anti-inflammatory effect: calm inflammatory cytokine；3. moistening effect: by reducing by 4. antioxygen of TEWL
Change effect: the protection to anti-oxidation stress reflection.
Butyrospermum parkii fruit rouge: Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit rouge is the food in pure plant source
Grade raw material, contains non-saponified ingredient abundant, is easily absorbed by the body, can not only prevent season cracking, moreover it is possible to further restore
And the natural elasticity of skin is kept, have effects that antiinflammation can also be played while deep layer is moistened.
Shea butter: being rich in moisturizing ingredient and vitamin, can make skin revitalization, eliminates skin small scar, freckles and skin
Color is uneven.It repairs the lipophilic film of skin, forms the protective layer of skin, provides the nourishing nursing of deep layer, effective protection for skin
With lasting moisturizing.Shea butter is helpful to the treatment of rosacea, eczema or acne.Rosacea is that face's blood vessel is swollen
Swollen, face area inflammation is red and swollen.Shea butter soothes the skin, and mitigates rubescent situation.Shea butter contain there are many vitamin A,
B, C, D, E, K, iron, calcium and protein, protection and reparation skin.Vitamin A in shea butter to improve skin (including
Freckles, wrinkle, eczema and dermatitis) it is important ingredient.In addition, good shea butter frost has treatment skin allergy, insect
It bites, tan severely, other situations of frostbite and skin.The incomparable moisture retention of shea butter is a variety of natural guarantors as contained by it
Humectant.Moisturizer in shea butter is identical as the moisturizer that the sebaceous glands in skin generates.
Redwood seed oil: natural pigment rich in carotenoid, soothes the skin, is particluarly suitable in baby care products and color make-up.
Tocopherol: outstanding natural can protect lipoprotein and unsaturated fatty acid in cell membrane, provide
The long-acting hair conditioning of skin and moisture retention.
Bisabolol: natural equivalent, high-purity/synthesis α-bisabolol 1) reduce scytitis；2) product thorn is reduced
Swash, improves the anti-irritant ability of skin；3) inflammation as caused by surfactant and alkaline matter is repaired；4) in sunscreen product
Spf value is improved, injury of the ultraviolet light to skin is reduced；5) mitigate the acne of skin；6) in washing away property product, have to skin attached
Property.Bisabolol is to be that famous Oily is releived agent.It is generally used for infant nursing articles.It is calm and releive various
Problem skin.
The present invention is with C10-30 acid cholesterine/lanosterol mixed ester, Atlantic Ocean helmet chest porgy oil, camellia seed oil, butter fruit
Tree fruit rouge, redwood seed oil, tocopherol and bisabolol are antipruritic active ingredients, and these types of ingredient is carried out compounding with good by discovery
Good reparation antipruritic effect, and carry out collocation use with anophelifuge activity and can also enhance antipruritic effect, so that plant of the invention
Mosquito-repellent antipruritic cream has mosquito repellent, antipruritic double effects, has good effect to treatment insect dermatitis.
Preferably, the parts by weight shared by plant mosquito-repellent antipruritic cream of each ingredient in the antipruritic active ingredients are by following
Meter: C10-30 acid cholesterine/0.1~20 part of lanosterol mixed ester, 0.1~10 part of Atlantic Ocean helmet chest porgy oil, camellia seed oil 0.1
~10 parts, 1~20 part of Butyrospermum parkii fruit rouge, 0.5~5 part of redwood seed oil, 0.01~1 part of tocopherol, bisabolol 0.01~2
Part.
Preferably, the parts by weight shared by plant mosquito-repellent antipruritic cream of each ingredient in the antipruritic active ingredients are by following
Meter: C10-30 acid cholesterine/0.1~20 part of lanosterol mixed ester, 0.1~10 part of Atlantic Ocean helmet chest porgy oil, camellia seed oil 0.1
~10 parts, 1~20 part of Butyrospermum parkii fruit rouge, 0.5~5 part of redwood seed oil, 0.01~1 part of tocopherol, bisabolol 0.01~2
Part.In antipruritic active ingredients of the present invention, the proportion of component will affect effect, the study found that in the preferred parts by weight range
Interior, the antipruritic effect of plant mosquito-repellent antipruritic cream of the present invention is more preferably.
Preferably, the plant mosquito-repellent antipruritic cream further includes thickener, the thickener be beeswax, by oil with hydrogenated soybean,
The compound that wheat, fine powder lipid, rice chaff sterol, hydrogenated olive oil, hydrogenated jojoba oil and tocopherol acetate form.
Beeswax: the present invention is using beeswax as thickener, the artificial synthesized wax that natural beeswax substitution tradition uses, natural beeswax
It is more beneficial to human health.
Phytolatum is (by oil with hydrogenated soybean, wheat, fine powder lipid, rice chaff sterol, hydrogenated olive oil, hydrogenation Jojoba
The compound of oil and tocopherol acetate composition) it is a kind of by being made in plant, the natural plants that can substitute hydro carbons vaseline mention
Object is taken, and is used as skin soft agent, regulator and moisturizer.By being carried out to vegetable oil such as soya-bean oil, olive oil and SIMMONDSIA CHINENSIS SEED OILs
Hydrogenation treatment, Phytolatum are made of the different various oil of degree of hydrogenation.In fact, Phytolatum makes in the fabrication process
With multiple fractions of same oil.This available more stable product, while it is also dissolved into this stability and finally matches
Fang Dangzhong.Research shows that same face cream is made more in VC face cream ratio vaseline or elastomer silicone made of Phytolatum
Add stabilization.
Preferably, the parts by weight shared by plant mosquito-repellent antipruritic cream of the ingredient in the thickener are based on following: beeswax 1~
10 parts, by oil with hydrogenated soybean, wheat, fine powder lipid, rice chaff sterol, hydrogenated olive oil, hydrogenated jojoba oil and tocopheryl acetate
2~60 parts of compound of ester composition.
Preferably, the plant mosquito-repellent antipruritic cream includes the ingredient of following parts by weight: C10-30 acid cholesterine/lanosterol
10 parts of mixed ester, 4 parts of Atlantic Ocean helmet chest porgy oil, 3 parts of camellia seed oil, 15 parts of Butyrospermum parkii fruit rouge, redwood seed oily 2 parts, tocopherol
0.2 part, 0.5 part of bisabolol, 1.5 parts of menthol, 1 part of Eucalyptus Globulus oil, 0.5 part of Blumea oil, 0.5 part of citronella grass oil, spearmint leaf
0.3 part of oil, 0.2 part of oil of geranium and 0.5 part of lavender oil.Present inventor has been surprisingly found that in many experiments,
Under the specific weight proportion, mosquito-expelling and antipruritic effect of the invention reaches best simultaneously.
Preferably, plant mosquito-repellent antipruritic cream further includes the ingredient of following parts by weight: 6 parts of beeswax, by oil with hydrogenated soybean, small
Wheat, fine powder lipid, rice chaff sterol, hydrogenated olive oil, hydrogenated jojoba oil and tocopherol acetate composition 54.8 parts of compound.
A kind of preparation method of the object mosquito-repellent antipruritic cream, comprising the following steps: 1) thickener is heated to 85-90
Degree, until solid is completely dissolved；2) antipruritic active ingredients are sequentially added, stirs evenly and 3) mixes anophelifuge activity ingredient, until peppermint
Alcohol is added in agitated kettle after being completely dissolved；4) inspection is sampled, is filtered out after qualified.
Beneficial effects of the present invention: the present invention all uses plant mosquito component, the mosquito repellent component of no pesticide formula；And it adds
A variety of organic natural components, ingredient is mild, and ointment shape is made, at low cost, of the invention by anophelifuge activity ingredient and antipruritic work
Property ingredient collocation use, can have mosquito repellent, antipruritic double effects, to treatment insect dermatitis have good effect.
Specific embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Each raw material manufacturer involved by following embodiment is as shown in table 1:
Table 1
Examples 1 to 6
The constituent and parts by weight content of plant mosquito-repellent antipruritic cream described in Examples 1 to 6 are as shown in table 2, this hair
The preparation method of the bright plant mosquito-repellent antipruritic cream: 1) A phase component is heated to 85-90 degree, until solid is completely dissolved；2) according to
Secondary addition B phase component, stirs evenly and 3) mixes C phase component, until menthol is added in agitated kettle after being completely dissolved；4) sampling is sent
Inspection filters out after qualified.
Table 2
The constituent and parts by weight content of plant mosquito-repellent antipruritic cream described in embodiment 7~16 are as shown in table 2:
Table 3
The constituent of plant mosquito-repellent antipruritic cream and the content of parts by weight described in comparative example 1~11 are as shown in table 4:
Table 4
The mosquito repellent of 17 plant mosquito-repellent antipruritic cream of embodiment is tested
Experimental method: referring to National Standard of the People's Republic of China, the indoor harmacological effect of agriculture chemical registration hygienic insecticide is commented
The method of valence repellant (GB/T17355.10-1998) is tested.It is 30cm × 30cm × 60cm mosquito in length × width × height
The aedes albopictus female mosquito that 300 4-5 ages in days are not sucked blood is put into cage.It wipes out after mouse web portion becomes mildewed, depilatory agent is applied to abdomen,
It is wiped after 5min with paper handkerchief, is rinsed well with tap water, dried with cotton balls.The depilation time does not answer too long, otherwise can destroy mouse
Skin.Test mice is fixed in the plastic plate for folding up mouse, abdomen is directed at the border circular areas (diameter for being put in hollow out
2.5cm), four limbs and tail are tightly wound with adhesive tape, cover skin.Examination mouse is put into 2min in mosquito cage, comes to stop the test worm fallen
More than 20 persons are that attack is qualified, this mouse and the cage mosquito can be used for repellency test.
Mosquito repellent test: mouse is handled with the aforedescribed process.In the abdomen skin that mouse exposes from border circular areas (diameter 2.5cm)
It (has lost hair or feathers) on skin, has uniformly smeared the 20 μ L of mosquito repellent product for examination, examination mouse is put into mosquito cage (inside having 300 or so female mosquitos), is seen
2min is examined, record thorn stings the mosquito quantity of mouse, is put into mosquito cage at interval of 1h and has seen whether bite by mosquitos, observe 8h altogether,
Observation 2min every time.It is per treatment to set 3 mouse repetitions, average value is surveyed, the mouse that setting abdomen smears 20 μ L dehydrated alcohols makees
The attacking ability of mosquito is observed in blank control.The Effective Vate of Protection of each mosquito-repellent perfume is calculated, calculation formula is as follows:
Effective Vate of Protection (%)=(mosquito thorn stings number after control mosquito thorn stings number-painting essential oil)/control mosquito thorn stings number
Shown in test data the following table 5 of Examples 1 to 6 and comparative example 1~5:
Table 5
| 2h protective rate % | 4h protective rate % | 6h protective rate % | 8h protective rate % | |
| Embodiment 1 | 100% | 100% | 100% | 93% |
| Embodiment 2 | 100% | 100% | 99% | 89% |
| Embodiment 3 | 100% | 100% | 97% | 82% |
| Embodiment 4 | 100% | 100% | 99% | 87% |
| Embodiment 5 | 100% | 100% | 99% | 85% |
| Embodiment 6 | 100% | 100% | 98% | 84% |
| Comparative example 1 | 100% | 100% | 90% | 80% |
| Comparative example 2 | 100% | 100% | 88% | 79% |
| Comparative example 3 | 100% | 100% | 89% | 80% |
| Comparative example 4 | 100% | 100% | 92% | 81% |
| Comparative example 5 | 100% | 100% | 94% | 81% |
As seen from the above table, the plant mosquito-repellent antipruritic cream of the embodiment of the present invention 1~6 has significant repelling effect, wherein with
The effect of embodiment 1 is best, finds by comparing the repelling effect of Examples 1 to 6 and comparative example 1~5, when other compositions with
Under 1 same case of embodiment, lack wherein menthol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, Pelargonium roseum
When one or both of oil and lavender oil ingredient, repelling effect can all have certain decline, illustrate when menthol, blue gum
With synergy when oil, Blumea oil, citronella grass oil, spearmint leaf oil, oil of geranium and lavender oil use simultaneously
Effect.
Shown in test data the following table 6 of embodiment 7~16:
Table 6
| 2h protective rate % | 4h protective rate % | 6h protective rate % | 8h protective rate % | |
| Embodiment 7 | 100% | 100% | 98% | 85% |
| Embodiment 8 | 100% | 100% | 100% | 90% |
| Embodiment 9 | 100% | 100% | 100% | 88% |
| Embodiment 10 | 100% | 100% | 99% | 87% |
| Embodiment 11 | 100% | 100% | 99% | 86% |
| Embodiment 12 | 100% | 100% | 99% | 85% |
| Embodiment 13 | 100% | 100% | 99% | 90% |
| Embodiment 14 | 100% | 100% | 99% | 91% |
| Embodiment 15 | 100% | 100% | 99% | 91% |
| Embodiment 16 | 100% | 100% | 98% | 90% |
As seen from the above table, the plant mosquito-repellent antipruritic cream of the embodiment of the present invention 7~16 has significant repelling effect, embodiment
7~11 plant mosquito-repellent antipruritic cream the difference from embodiment 1 is that, menthol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint
The difference of the content of leaf oil, oil of geranium and lavender oil, experimental result discovery, when based on following parts by weight: menthol 1
~1.8 parts, 0.8~1.4 part of Eucalyptus Globulus oil, 0.4~0.8 part of Blumea oil, 0.4~0.8 part of citronella grass oil, spearmint leaf oil 0.2~
At 0.6 part, 0.1~0.6 part and 0.3~0.7 part of lavender oil of oil of geranium, repelling effect is preferable, and embodiment 12
~16 plant mosquito-repellent antipruritic cream the difference from embodiment 1 is that, C10-30 acid cholesterine/lanosterol mixed ester, the Atlantic Ocean
The difference of the content of helmet chest porgy oil, camellia seed oil, Butyrospermum parkii fruit rouge, redwood seed oil, tocopherol, bisabolol, and from experiment
As a result, it has been found that repelling effect is slightly better than the effect of embodiment 7~11, but there is decline compared with Example 1, shows master of the present invention
The main component for playing repelling effect is menthol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, Pelargonium roseum
Oil and lavender oil, but C10-30 acid cholesterine/lanosterol mixed ester, Atlantic Ocean helmet chest porgy oil, camellia seed oil, butter simultaneously
Fruit tree fruit rouge, redwood seed oil, tocopherol, bisabolol content will affect repelling effect.
The antipruritic test of 18 plant mosquito-repellent antipruritic cream of embodiment
Experimental method: taking mouse 270, male female fifty-fifty, is randomly divided into 27 groups, this experiment with physiological saline as a control group
Reagent, apply embodiment and comparative example products obtained therefrom.
First day by mouse it is right after instep unhairing, and 1cm at the shaving of instep is uniformly abraded with coarse sandpaper2.Second day small
The itching-relieving cream of embodiment and comparative example is embrocated at the surface of a wound of mouse instep respectively, the amount of embrocating is 0.5ml/ every time.3 times a day, it applies altogether
It wipes 7 times.After last embrocates 30min, histamine phosphate normal saline solution is dripped to the mouse instep surface of a wound, is then incremented by every 3min
Histamine phosphate normal saline solution concentration.Its concentration is respectively 0.01%, 0.02%, 0.03%, 0.04% incremented by successively, concentration
Increase by 0.01%, each dripping quantity 0.05ml every time, until mouse later licks right metapedes.The total amount of computation organization's amine, as
Cause of the invention is itched valve；Compared with blank control group, group difference analysis is carried out.
Shown in itching-relieving action test result the following table 7 of Examples 1 to 6 and comparative example 6~11:
Table 7
Studies have shown that histamine is a kind of important mediator that can cause pruitus.Mouse is in normal circumstances by anti-
After primary stimuli, skin lesion, pathology and immune etc. feature are consistent with mankind's dystopy skin lesion.It is above-mentioned the experimental results showed that, this hair
The mosquito-repellent antipruritic cream of bright Examples 1 to 6 preparation can all effectively inhibit pruitus caused by histamine phosphate, wherein to implement
The effect of example 1 is best, finds by comparing the antipruritic effect of Examples 1 to 6 and comparative example 7~10, when in other compositions and reality
It applies under 1 same case of example, lacks C10-30 acid cholesterine/lanosterol mixed ester, Atlantic Ocean helmet chest porgy oil, camellia seed oil, ox
When oily fruit tree fruit rouge, redwood seed oil, tocopherol, bisabolol be one such or two kinds of ingredients, antipruritic effect and embodiment 1
Compared to can all there is certain decline, illustrate when C10-30 acid cholesterine/lanosterol mixed ester, Atlantic Ocean helmet chest porgy oil, camellia
Seed oil, Butyrospermum parkii fruit rouge, redwood seed oil, tocopherol, bisabolol have an antipruritic effect, and its effect only while when using
It can be only achieved most preferably, comparative example 11 is with the difference of embodiment 1, without containing menthol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, stays
Blue geranium oil, oil of geranium and lavender oil ingredient, as can be known from the results, antipruritic effect have centainly relative to embodiment 1
Decline, show menthol of the invention, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, oil of geranium and smoke
Clothing grass oil component will affect antipruritic effect, when with C10-30 acid cholesterine/lanosterol mixed ester, the Atlantic Ocean helmet chest porgy oil, mountain
Tea-seed oil, Butyrospermum parkii fruit rouge, redwood seed oil, tocopherol, bisabolol same used time, can play optimal antipruritic effect.
Shown in antipruritic test data the following table 8 of embodiment 7~16:
Table 8
As seen from the above table, the plant mosquito-repellent antipruritic cream of the embodiment of the present invention 7~16 has significant antipruritic effect, embodiment
12~16 plant mosquito-repellent antipruritic cream the difference from embodiment 1 is that, C10-30 acid cholesterine/lanosterol mixed ester, great Xi
The difference of the content of foreign helmet chest porgy oil, camellia seed oil, Butyrospermum parkii fruit rouge, redwood seed oil, tocopherol, bisabolol, experiment knot
Fruit discovery, when based on following parts by weight: C10-30 acid cholesterine/8~14 parts of lanosterol mixed ester, Atlantic Ocean helmet chest porgy oil
2.5~5 parts, 2~3.5 parts of camellia seed oil, 12~16 parts of Butyrospermum parkii fruit rouge, 1.2~2.5 parts of redwood seed oil, tocopherol 0.15
At~0.5 part, 0.3~1 part of bisabolol, antipruritic effect is preferable, and the plant mosquito-repellent antipruritic cream of embodiment 7~11 and implementation
The difference of example 1 is, menthol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, oil of geranium and lavender oil
Content difference, and from experimental result find, antipruritic effect is slightly better than the effect of embodiment 12~16, but with embodiment 1
Compared to there is decline, the main component for showing that the present invention primarily serves antipruritic effect is C10-30 acid cholesterine/lanosterol mixing
Ester, Atlantic Ocean helmet chest porgy oil, camellia seed oil, Butyrospermum parkii fruit rouge, redwood seed oil, tocopherol, bisabolol, but peppermint simultaneously
Alcohol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, oil of geranium and lavender oil content will affect antipruritic effect
Fruit, and research has shown that the embodiment of the present invention 1 regardless of all reaching optimal effect in terms of antipruritic or repelling effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent substitution, improvement and etc. done be should be included within the scope of the present invention.
Claims (10)
1. a kind of plant mosquito-repellent antipruritic cream, which is characterized in that including anophelifuge activity ingredient, the anophelifuge activity ingredient includes peppermint
Alcohol, Eucalyptus Globulus oil, Blumea oil, citronella grass oil, spearmint leaf oil, oil of geranium and lavender oil, the anophelifuge activity ingredient
In each ingredient parts by weight shared by plant mosquito-repellent antipruritic cream based on following: 0.1~5 part of menthol, Eucalyptus Globulus oil 0.01~3
Part, 0.01~2 part of Blumea oil, 0.01~2 part of citronella grass oil, 0.01~2 part of spearmint leaf oil, oil of geranium 0.01~2
Part and 0.01~2 part of lavender oil.
2. plant mosquito-repellent antipruritic cream according to claim 1, which is characterized in that in the anophelifuge activity ingredient it is each at
Divide the parts by weight shared by plant mosquito-repellent antipruritic cream based on following: 1~1.8 part of menthol, 0.8~1.4 part of Eucalyptus Globulus oil, Blumea oil
0.4~0.8 part, 0.4~0.8 part of citronella grass oil, 0.2~0.6 part of spearmint leaf oil, 0.1~0.6 part of oil of geranium with smoke
0.3~0.7 part of oil of clothing grass.
3. plant mosquito-repellent antipruritic cream according to claim 1, which is characterized in that it further include antipruritic active ingredients, it is described to stop
Itching activity ingredient includes C10-30 acid cholesterine/lanosterol mixed ester, Atlantic Ocean helmet chest porgy oil, camellia seed oil, Butyrospermum parkii
Fruit rouge, redwood seed oil, tocopherol and bisabolol.
4. plant mosquito-repellent antipruritic cream according to claim 3, which is characterized in that in the antipruritic active ingredients it is each at
Divide the parts by weight shared by plant mosquito-repellent antipruritic cream based on following: C10-30 acid cholesterine/lanosterol mixed ester 0.1~20
Part, 0.1~10 part of Atlantic Ocean helmet chest porgy oil, 0.1~10 part of camellia seed oil, 1~20 part of Butyrospermum parkii fruit rouge, redwood seed oil 0.5
~5 parts, 0.01~1 part of tocopherol, 0.01~2 part of bisabolol.
5. plant mosquito-repellent antipruritic cream according to claim 3, which is characterized in that in the antipruritic active ingredients it is each at
Divide the parts by weight shared by plant mosquito-repellent antipruritic cream based on following: C10-30 acid cholesterine/lanosterol mixed ester 0.1~20
Part, 0.1~10 part of Atlantic Ocean helmet chest porgy oil, 0.1~10 part of camellia seed oil, 1~20 part of Butyrospermum parkii fruit rouge, redwood seed oil 0.5
~5 parts, 0.01~1 part of tocopherol, 0.01~2 part of bisabolol.
6. plant mosquito-repellent antipruritic cream according to claim 4, which is characterized in that further include thickener, the thickener is
Beeswax, by oil with hydrogenated soybean, wheat, fine powder lipid, rice chaff sterol, hydrogenated olive oil, hydrogenated jojoba oil and tocopheryl acetate
The compound of ester composition.
7. object mosquito-repellent antipruritic cream according to claim 6, which is characterized in that the ingredient in the thickener is mosquito-proof in plant
Parts by weight shared by itching-relieving cream are based on following: 1~10 part of beeswax, by oil with hydrogenated soybean, wheat, fine powder lipid, rice chaff sterol, hydrogen
2~60 parts of compound for changing olive oil, hydrogenated jojoba oil and tocopherol acetate composition.
8. object mosquito-repellent antipruritic cream according to claim 1, which is characterized in that the ingredient including following parts by weight: C10-30
It is sour cholesterine/10 parts of lanosterol mixed ester, 4 parts of Atlantic Ocean helmet chest porgy oil, 3 parts of camellia seed oil, 15 parts of Butyrospermum parkii fruit rouge, red
The wooden seed oily 2 parts, 0.2 part of tocopherol, 0.5 part of bisabolol, 1.5 parts of menthol, 1 part of Eucalyptus Globulus oil, 0.5 part of Blumea oil, nardgrass
0.5 part of oil, 0.3 part of spearmint leaf oil, 0.2 part of oil of geranium and 0.5 part of lavender oil.
9. object mosquito-repellent antipruritic cream according to claim 8, which is characterized in that further include the ingredient of following parts by weight: beeswax 6
Part, by oil with hydrogenated soybean, wheat, fine powder lipid, rice chaff sterol, hydrogenated olive oil, hydrogenated jojoba oil and tocopherol acetate
54.8 parts of the compound of composition.
10. a kind of preparation method of such as described in any item object mosquito-repellent antipruritic cream of claim 6,7,9, which is characterized in that including
Following steps: 1) being heated to 85-90 degree for thickener, until solid is completely dissolved；2) antipruritic active ingredients are sequentially added, stirring is equal
It is even 3) to mix anophelifuge activity ingredient, until menthol is added in agitated kettle after being completely dissolved；4) inspection is sampled, is filtered out after qualified
Come.
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