CN107184448A - A kind of acne eliminating cream that there is prevention pockmark to generate - Google Patents

A kind of acne eliminating cream that there is prevention pockmark to generate Download PDF

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Publication number
CN107184448A
CN107184448A CN201710302588.XA CN201710302588A CN107184448A CN 107184448 A CN107184448 A CN 107184448A CN 201710302588 A CN201710302588 A CN 201710302588A CN 107184448 A CN107184448 A CN 107184448A
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Prior art keywords
extract
pockmark
prevention
root extract
acne
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殷传江
杜养标
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Guangzhou Rui Yu Chemical Technology Co Ltd
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Guangzhou Rui Yu Chemical Technology Co Ltd
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Priority to CN201710302588.XA priority Critical patent/CN107184448A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Abstract

The invention discloses a kind of acne eliminating cream that there is prevention pockmark to generate, comprise the following raw materials by weight percent:Hydrolecithin, laruyl alcohol phosphate potassium, evening primrose oil, cetostearyl alcohol, bisabolol, isoflavones, vitamin E, dimethyl silicone polymer, disodium ethylene diamine tetraacetate, glycerine, carbomer, arginine, Sodium Hyaluronate, wrinkle leaf lily magnolia bark extract, arhat cypress branch extract, pummelo peel extract, canaline, glycyrrhiza glabra root extract, giant knotweed root extract, green-tea extract, german chamomile flower extract, radix scutellariae root extract, Gotu Kola P.E, glycerol caprylate, decoyl hydroximic acid, surplus is water;This have prevention pockmark generation acne eliminating cream can not only quickly anti-acne and with prevention pockmark generation function, also with property it is gentle, it is low stimulation etc. superperformance.

Description

A kind of acne eliminating cream that there is prevention pockmark to generate
Technical field
The present invention relates to a kind of acne eliminating cream that there is prevention pockmark to generate.
Background technology
Acne refers to whelk, is being commonly called as acne, also known as " dark sore ", " acne ", and the generation of acne is mainly and sebum secretion Excessively, pilosebaceous duct block, the factor such as bacterium infection and inflammatory reaction it is closely related.Adolesce male in descendant's body The level of hormone particularly testosterone is raised rapidly, promotes sebaceous glands to develop and produce a large amount of sebums.While pilosebaceous duct Dyskeratosis cause catheter blockage, dyssebacia, it is micro mist thorn to form horn plug.Multiple-microorganism is especially in hair follicle Propionibacterium acnes amount reproduction, the lipase that propionibacterium acnes is produced decomposes sebum generation free fatty, while chemotactic is scorching Disease cell and medium, finally induce and aggravate inflammatory reaction.
Pockmark is also known as acne scar, is that a kind of repair that body is produced to tissue damage is reacted, when the damage depth and corium of skin Or the skin blemish of large area, the epidermis at the position can not regenerate, will be by corium fabric cell, the blood vessel institute of collagen and hyperplasia Substitution, thus occurs in that acne scar.Acne scar is because infection inflammation or external force extruding are formed, often because in whelk hair As when do not obtain appropriate treatment in time, the inflammatory response of Skin Cell causes the destruction to skin histology, causes scar The generation of trace.Because the species of whelk is of all kinds, so the form of whelk scar also has a lot of kinds, and during whelk breaking-out Inflammatory response it is more serious, skin histology also destroys more severe;The position of inflammation is deeper, and skin histology is also more destroyed Deep, the acne scar that may be left in the future is also more serious.
Acne print be whelk breaking-out when cause blood vessel dilatation, whelk disappear down after blood vessel can't contract down at once, just Some average red erythema are formd (to be commonly called as:Red seal), and the inflammatory response of Skin Cell causes and skin histology is broken Bad, the pigementation after inflammation can make the place for growing red small pox leave black dirty color (to be commonly called as:Black print), thus shape Into acne print.
The content of the invention
In view of this, it is an object of the present invention to provide it is a kind of can not only quickly anti-acne and with prevention pockmark generation function, Also there is the acne eliminating cream with prevention pockmark generation of the superperformances such as gentle, the low stimulation of property.
In order to solve the above-mentioned technical problem, the technical scheme is that:
A kind of acne eliminating cream that there is prevention pockmark to generate, is comprised the following raw materials by weight percent:Hydrolecithin 1.5%th, laruyl alcohol phosphate potassium 0.3%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, bisabolol 0.2-0.8%, big It is beans isoflavones 0.2-0.5%, vitamin E 0.2%, dimethyl silicone polymer 1.0%, disodium ethylene diamine tetraacetate 0.05%, sweet Oil 6.0%, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark extract 0.3-0.5%, Arhat cypress branch extract 0.3-0.5%, pummelo peel extract 0.3-0.5%, canaline 0.5-1.5%, glycyrrhiza glabra root are carried Take thing 0.3-0.5%, giant knotweed root extract 0.3-0.5%, green-tea extract 0.3-0.5%, german chamomile flower extract 0.3- 0.5%th, radix scutellariae root extract 0.3-0.5%, Gotu Kola P.E 0.3-0.8%, glycerol caprylate 0.2%, decoyl hydroximic acid 0.3%th, surplus is water.
Further, comprise the following raw materials by weight percent:Hydrolecithin 1.5%, laruyl alcohol phosphate potassium 0.3%th, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, bisabolol 0.2%, isoflavones 0.2%, vitamin E 0.2%th, dimethyl silicone polymer 1.0%, disodium ethylene diamine tetraacetate 0.05%, glycerine 6.0%, carbomer 0.2%, arginine 0.2%th, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark extract 0.3%, arhat cypress branch extract 0.3%, pummelo peel extract 0.3%th, canaline 0.5%, glycyrrhiza glabra root extract 0.3%, giant knotweed root extract 0.3%, green-tea extract 0.3%th, german chamomile flower extract 0.3%, radix scutellariae root extract 0.3%, Gotu Kola P.E 0.3, glycerol caprylate 0.2%, pungent Acyl hydroximic acid 0.3%, surplus are water.
Further, comprise the following raw materials by weight percent:Hydrolecithin 1.5%, laruyl alcohol phosphate potassium 0.3%th, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, bisabolol 0.8%, isoflavones 0.5%, vitamin E 0.2%th, dimethyl silicone polymer 1.0%, disodium ethylene diamine tetraacetate 0.05%, glycerine 6.0%, carbomer 0.2%, arginine 0.2%th, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark extract 0.5%, arhat cypress branch extract 0.5%, pummelo peel extract 0.5%th, canaline 1.5%, glycyrrhiza glabra root extract 0.5%, giant knotweed root extract 0.5%, green-tea extract 0.5%th, german chamomile flower extract 0.5%, radix scutellariae root extract 0.5%, Gotu Kola P.E 0.8%, glycerol caprylate 0.2%, Decoyl hydroximic acid 0.3%, surplus are water.
Further, comprise the following raw materials by weight percent:Hydrolecithin 1.5%, laruyl alcohol phosphate potassium 0.3%th, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, bisabolol 0.5%, isoflavones 0.35%, vitamin E 0.2%th, dimethyl silicone polymer 1.0%, disodium ethylene diamine tetraacetate 0.05%, glycerine 6.0%, carbomer 0.2%, arginine 0.2%th, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark extract 0.4%, arhat cypress branch extract 0.4%, pummelo peel extract 0.4%th, canaline 1.0%, glycyrrhiza glabra root extract 0.4%, giant knotweed root extract 0.4%, green-tea extract 0.4%th, german chamomile flower extract 0.4%, radix scutellariae root extract 0.4%, Gotu Kola P.E 0.55%, glycerol caprylate 0.2%, Decoyl hydroximic acid 0.3%, surplus are water.
The technology of the present invention effect major embodiment is in the following areas:Can not only quickly anti-acne and with prevention pockmark generation work( Can, also with superperformances such as gentle, the low stimulations of property
Embodiment
With reference to embodiments, the embodiment to the present invention is described in further detail, so that technical solution of the present invention It is more readily understood and grasps.
Embodiment 1:
A kind of acne eliminating cream that there is prevention pockmark to generate, is comprised the following raw materials by weight percent:Hydrolecithin 1.5%th, laruyl alcohol phosphate potassium 0.3%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, bisabolol 0.2%, soybean are different Flavones 0.2%, vitamin E 0.2%, dimethyl silicone polymer 1.0%, disodium ethylene diamine tetraacetate 0.05%, glycerine 6.0%, Carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark extract 0.3%, arhat cypress branch are extracted Thing 0.3%, pummelo peel extract 0.3%, canaline 0.5%, glycyrrhiza glabra root extract 0.3%, giant knotweed root extract 0.3%th, green-tea extract 0.3%, german chamomile flower extract 0.3%, radix scutellariae root extract 0.3%, Gotu Kola P.E 0.3, sweet Oily caprylate 0.2%, decoyl hydroximic acid 0.3%, surplus are water.
Embodiment 2:
A kind of acne eliminating cream that there is prevention pockmark to generate, is comprised the following raw materials by weight percent:Hydrolecithin 1.5%th, laruyl alcohol phosphate potassium 0.3%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, bisabolol 0.8%, soybean are different Flavones 0.5%, vitamin E 0.2%, dimethyl silicone polymer 1.0%, disodium ethylene diamine tetraacetate 0.05%, glycerine 6.0%, Carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark extract 0.5%, arhat cypress branch are extracted Thing 0.5%, pummelo peel extract 0.5%, canaline 1.5%, glycyrrhiza glabra root extract 0.5%, giant knotweed root extract 0.5%th, green-tea extract 0.5%, german chamomile flower extract 0.5%, radix scutellariae root extract 0.5%, Gotu Kola P.E 0.8%, Glycerol caprylate 0.2%, decoyl hydroximic acid 0.3%, surplus are water.
Embodiment 3:
A kind of acne eliminating cream that there is prevention pockmark to generate, is comprised the following raw materials by weight percent:Hydrolecithin 1.5%th, laruyl alcohol phosphate potassium 0.3%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, bisabolol 0.5%, soybean are different Flavones 0.35%, vitamin E 0.2%, dimethyl silicone polymer 1.0%, disodium ethylene diamine tetraacetate 0.05%, glycerine 6.0%th, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark extract 0.4%, Thujopsis dolabrata Branch extract 0.4%, pummelo peel extract 0.4%, canaline 1.0%, glycyrrhiza glabra root extract 0.4%, polygoni cuspidati,radix are carried Take thing 0.4%, green-tea extract 0.4%, german chamomile flower extract 0.4%, radix scutellariae root extract 0.4%, Gotu Kola P.E 0.55%th, glycerol caprylate 0.2%, decoyl hydroximic acid 0.3%, surplus are water.
Principle explanation:
The first composition of the present invention is containing one group of plant extracts with stronger bactericidal effect.Wrinkle leaf umbrella tree Bark extract is rich in magnolol magnolia obovata alcohol, and research has shown that wrinkle leaf lily magnolia bark extract has strong antibacterial action, to deformation hammer The minimum inhibitory concentration (MIC) of bacterium is 6.3 μ g/ml, and its antibacterial action is more stronger than berberine.Its aqueous solution is to Staphylococcus aureus Bacterium, sarcine and hay bacillus have certain bacteriostasis;Arhat cypress branch extract can be used as food preservative.Thujopsis dolabrata is carried Take the main component of thing to keep side element or hinokitol or thujaplicin, have tri- kinds of isomers of α, β, γ.α-keep the plain fusing point 82 in side DEG C, β-keep plain 52~52.5 DEG C of the fusing point in side, γ-keep plain 82 DEG C of the fusing point in side.Mixture is white to yellow crystal or crystallinity powder End, with the distinctive fragrance of Thujopsis dolabrata.Thujopsis dolabrata extract has very strong sterilizing ability, has to bacterium, mould, yeast etc. Fine inhibition;Pummelo peel extract, pummelo peel extract is stronger to the inhibitory action of Escherichia coli and staphylococcus aureus, its MIC is 2.5%, and the inhibitory action to salmonella is weaker, its MIC > 2.5%, the suppression of pH value and temperature to pummelo peel extract Bacterium activity has an impact, and fungistatic effect is preferable under the conditions of slant acidity.Therefore currently preferred group there is stronger sterilization to imitate The plant extracts of fruit is wrinkle leaf lily magnolia bark extract, arhat cypress branch extract and pummelo peel extract.
Second of composition of the present invention is the natural origin product of energy softening skin cutin.U.S. Biocogent is by making It is a kind of specific yeast-leavened canaline to produce DermalRx SRC by zymotechnique with the yeast strain of patent, DermalRx SRC are by effectively stimulating the renewal of cuticula and the normal of cell more to newly arrive to help improve aging and furfur Skin, human body skin test shows that glycolic of the exfoliation than 8% that DermalRx SRC are shown is also good, and its is right Skin is almost non-stimulated.Therefore the natural origin product in the present invention being energy softening skin cutin is a kind of specific yeast-leavened Canaline.
The third composition of the present invention is one group of plant extracts that can have stronger anti-inflammatory and suppress the effect of inflammation.Before Soviet Union's scholar's research shows that radix glycyrrhizae has stronger anti-inflammatory and anti-metamorphosis, and the drug effect than sulfanilamide (SN) and antibiotic is good, furthermore Radix glycyrrhizae has the effect of preferably anti-oxidant and Green Tea Extract;Giant knotweed is one of plant of polygonaceae, and its is primary to be longer than East Asia and wide It is general to be distributed in China.Giant knotweed be used to treat a variety of slight illness in China and japanese traditional medicine, many including mycotic infection Plant scytitis, angiocardiopathy and liver diseases etc..Resveratrol and rheum emodin are the main functional components in giant knotweed.Research Display resveratrol and rheum emodin show extensive anti-oxidation characteristics, such as LDL-C oxidation and peroxidatic reaction of lipid.In vain Veratryl alcohol is shown simultaneously contributes to cardiovascular health and promoting blood circulation, mitigates pain, and clearing heat and removing internal wetness, detoxification removes phlegm;Green-tea extract Can be as natural food oxidant, because no matter in terms of antioxidant, security or use cost, its main component Tea Polyphenols is equal It is substantially better than synthetized oxidation preventive agent BHA, BHT, TBHQ, PG and VE for being widely used currently on the market, VC etc..Green tea is extracted Thing also can be as cosmetics and the excellent additive of household chemicals, and it has very strong antibacterial action and Inhibitory activity.It can prevent and treat Skin disease, allergic effect, remove skin pigment, hair carious tooth, dental plaque, periodontitis and halitosis etc.;German chamomile flower extract has only Pain function, can relax vexed myalgia, the pain especially caused by nervous, mitigate and scald, blister, the wound of inflammation Mouthful, help improve eczema, pimples, bleb, chronic eczema, hypersensitization skin, and general allergic phenomena.Having in radix scutellariae root extract It is baicalin to imitate composition, and baicalin increases to the swelling in inflammatory process, capillary permeability, tissue fluid oozes out and leucocyte Migration has obvious inhibitory action, and this effect is suppressed relevant with inflammatory factor PGE2 generation and release.Therefore this hair It is that glycyrrhiza glabra root extract, polygoni cuspidati,radix are carried that one group, which can have stronger anti-inflammatory and suppress the plant extracts of the effect of inflammation, in bright Take thing, green-tea extract, german chamomile flower extract and radix scutellariae root extract.
The 4th kind of composition of the present invention wherein has the pigmented plant extracts that can suppress inflammation initiation.South Korea The research of DERMAPRO skins research center, which is proved to be the bisabolol extracted from Brazilian Ka Deya trees, has good skin beautiful White effect.Therefore the present invention in have can suppress inflammation initiation pigmented plant extracts be from Brazilian Ka Deya trees The bisabolol of extraction.
The 5th kind of composition of the present invention is the natural extract with the scar generation that can suppress inflammation skin.Centella contains There are a variety of triterpenes, wherein including α-amyrin structure.Main component is Asiaticoside, asiatic acid and madacasso grass Acid.Find that Gotu Kola P.E can promote collagen I and III synthesis, while can also promote by the scientific researches of more than 20 years Enter the secretion (synthesis of such as hyaluronic acid) of mucopolysaccharide, increase the water conservation degree of skin, activation updates Skin Cell, skin is relaxed Delay, lifted and rich in reflecting feel;On the other hand testing research is arranged by cDNA and also found that Gotu Kola P.E also has into fibre The activation of cytogene is tieed up, the vigor of skin basal layer cell can be strengthened, elasticity of skin and consolidation sense, smooth face is kept Fine wrinkles.By experiment, it was also found that using asiaticosid and the madecassoside of various dose act in vitro culture into After fibrocyte (HumanSkinFibroblast, HSFb), pass through the method determination experiment group and blank control group of radio-immunity I procollagen types aminoterminal peptide former (P I NP) and type III precollagen aminoterminal peptide former (PIII NP) content in cell supernatant. As a result show:1. compared with blank control group, asiaticosid and madecassoside can effective stimulus in vitro culture HSFbP I NP and PIIINP secretion;2. asiaticosid and madecassoside stimulate the biology of target cell PINP and PIIINP secretion to make With the obvious dose-effect relationship of presentation;3. in the μ g/mL dosage of 10 μ g/mL~150, Ad stimulates P I NP secretion to show HSFb Go out the bioactivity more stronger than Md.The natural extract therefore in the present invention with the scar generation that can suppress inflammation skin is long-pending The careless extract of snow.
The 6th kind of composition of the present invention is at least containing a kind of plant extracts for the function of having and suppress sebum secretion.Greatly Beans isoflavones is typical phytoestrogen, and isoflavones can be combined performance estrogen-like action with ER instead of estrogen, be entered The level for entering androgen particularly testosterone in puberty descendant's body is raised rapidly, promotes sebaceous glands to develop and produce a large amount of sebums, And isoflavones can balance the secretion of testosterone, so as to reduce the sebum secretion of sebaceous glands.Therefore have in the present invention and suppress skin The plant extracts of the function of fat secretion is isoflavones
This six kinds are chosen the natural function composition come, and the symptom of formation mechenism and affected skin from whelk is set about, Take " from outside to inside ", " by mark to originally ", the maintenance scheme of multipath.
Foregoing skin care compositions can by by required composition in suitable container, at ambient conditions Its mixing is prepared, any conventional mixing apparatus well known in the art can be used during preparation, such as:Emulsifying homogeneous pot etc..It is mixed Needed during conjunction the molten and water-soluble difference Hybrid Heating of oil to 80 DEG C, then oil phase is mixed with water conjunction stirring homogeneous, cools to Innate efficacy thing is added at 45 DEG C.
Experimental example
Object and method
Object
Take random, open, Self-controlled study.Hubei dept. of dermatology of Jianghan Oil-field central hospital homeliness type acne is chosen to suffer from Person amounts to 50 (Pillshaury acne classification I levels 28, II levels 22), wherein male patient 27, female patient 23 Example, the age (19.8 ± 1.9) year, individual month of the course of disease (20.0 ± 18.7).All patient's voluntary participation clinical observations, signature is known same Meaning book, and promise uses the acne eliminating cream on request.
Inclusion criteria:1. it is to take glucocorticoid, dimension A classes medicine, antibiotic etc. in 2 weeks before clinical observation, and is seeing Without using said medicine during examining;2. do not indulged in excessive drinking during observing, excessive maror is not eaten.
Research method
Application method:Patient daily sooner or later by Irrigation it is clean after acne eliminating cream is uniformly applied to affected part, continue 28d with On, it is impossible to it is interrupted.
Observation item and scoring
Skin damaged improves situation:Patient using the 7th after preceding and use, 14,28d respectively observation once, record uses front and rear skin Damage improvement situation.Acne, papule, useless fellow, tubercle tumour, seborrhea degree are scored according to 4 grades of point systems, while observation is simultaneously Record adverse reaction.
Pockmark improves situation:Patient using the 7th after preceding and use, 14,28d respectively observation once, record uses front and rear acne Trace improves situation.
Curative effect judging standard:
Degree is improved according to skin damaged, therapeutic index is calculated, judges curative effect.Therapeutic index=(long-pending after integration-treatment before treatment Point) the preceding integration × 100% of/treatment.It is almost recovered:Therapeutic index > 75%, it is effective:Therapeutic index:50~75%, effectively:Treat Imitate index:20~50%, it is invalid:Therapeutic index < 20%.
Improve situation for pockmark, we are defined as follows:Pockmark reduces more than 50% and is designated as effective, and 20~50% is have Effect, < 20% is invalid.
Statistical analysis
Data is handled using SPSS statistical softwares, is examined using variance analysis and t and carries out statistical analysis, P < 0.05 is that significant difference is notable.
The patients with acne vulgaris of table 1 uses the comparison (example) of various skin damaged curative effects after anti-acne repair cream
Note:1) A, B, C represent respectively use anti-acne repair cream after the 7th, 14,28d.
2) Chi-square Test is calculated using Ficher exact propability.
3) * B are compared with A, and material B is compared with C, and #C is compared with A.
The patients with acne vulgaris of table 2 using the 7th after anti-acne repair cream, 14,28d clinical effectiveness compares (example)
Note:1) A, B, C represent respectively use anti-acne repair cream after the 7th, 14,28d.
2) Chi-square Test is calculated using Ficher exact propability.
3) * B are compared with A, and * * B are compared with C, and #C is compared with A.
The patients with acne vulgaris pockmark of table 3 improves situation (example)
Note:1) A, B, C represent respectively use anti-acne repair cream after the 7th, 14,28d.
2) Chi-square Test is calculated using Ficher exact propability.
3) * B are compared with A, and * * B are compared with C, and #C is compared with A.
0.01 note:1) A, B, C represent respectively use anti-acne repair cream after the 7th, 14,28d.
2) Chi-square Test is calculated using Ficher exact propability.
3) * B are compared with A, and * * B are compared with C, and #C is compared with A.
Result of study shows that anti-acne repair cream has to patient's acne, papule, useless fellow, tubercle tumour, seborrhea significantly to be controlled Therapeutic effect, was visible certain effect after the 7th day, the rate that is almost recovered improves with the extension of use time, uses the 28th It the rate that is almost recovered is up to more than 90%;Anti-acne repair cream can also promote patient's pockmark to improve, and to the 28th day, pockmark improved effective Rate is up to 80%.
As a result
Skin damaged improves assessment of scenario
Patient is using after acne eliminating cream 7d of the present invention, and acne, papule and seborrhea are clearly better, to acne, papule and purulence after 28d The rate that is almost recovered of blister is up to 90%, and also having to nodositas tumour significantly improves, and its effective percentage is 80%;Using 14d, 28d and 7d indices have significant difference (table 1).
2.2 clinical curative effect analysis
After acne eliminating cream 7d of the present invention, existing 20% patient is almost recovered (10/50), and 14d, 28d acne are basic Cure rate is respectively 60% (30/50) and 92% (46/50), and clinical effectiveness is superior to 7d (P < 0.05), and 28d is better than the 14d (P < 0.05), is shown in Table 2.
Patient is used after anti-acne repair cream 7d, and pockmark is visible to take a turn for the better (22/46) to a certain degree, and 14d, 28d pockmark improve Substantially, its effective percentage respectively reaches 65% (30/46) and 80% (37/46), the 28th, 14,7d be compared to each other significant difference (P < 0.05), is shown in Table 3.
2.3 adverse reaction
During acne eliminating cream of the present invention, do not occur adverse reaction, patient is reflected that the sense of this acne eliminating cream skin is good, do not pierced Swash property and uncomfortable sensation, all patients complete whole experiment.
The technology of the present invention effect major embodiment is in the following areas:Can not only quickly anti-acne and with prevention pockmark generation work( Can, also with superperformances such as gentle, the low stimulations of property.
Certainly, it is the representative instance of the present invention above, in addition, the present invention can also have other a variety of specific implementations The technical scheme of mode, all use equivalent substitutions or equivalent transformation formation, all falls within the scope of protection of present invention.

Claims (4)

1. a kind of acne eliminating cream that there is prevention pockmark to generate, it is characterised in that:Comprise the following raw materials by weight percent:Hydrogenation Lecithin 1.5%, laruyl alcohol phosphate potassium 0.3%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, bisabolol 0.2- 0.8%th, isoflavones 0.2-0.5%, vitamin E 0.2%, dimethyl silicone polymer 1.0%, disodium ethylene diamine tetraacetate 0.05%th, glycerine 6.0%, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark extract 0.3-0.5%, arhat cypress branch extract 0.3-0.5%, pummelo peel extract 0.3-0.5%, canaline 0.5-1.5%, light Fruit licorice root extract 0.3-0.5%, giant knotweed root extract 0.3-0.5%, green-tea extract 0.3-0.5%, Flos Chrysanthemi are extracted Thing 0.3-0.5%, radix scutellariae root extract 0.3-0.5%, Gotu Kola P.E 0.3-0.8%, glycerol caprylate 0.2%, decoyl Hydroximic acid 0.3%, surplus are water.
2. the acne eliminating cream according to claim 1 that there is prevention pockmark to generate, it is characterised in that:By following percentage by weight Raw material composition:Hydrolecithin 1.5%, laruyl alcohol phosphate potassium 0.3%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, Bisabolol 0.2%, isoflavones 0.2%, vitamin E 0.2%, dimethyl silicone polymer 1.0%, ethylenediamine tetra-acetic acid two Sodium 0.05%, glycerine 6.0%, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark are extracted Thing 0.3%, arhat cypress branch extract 0.3%, pummelo peel extract 0.3%, canaline 0.5%, glycyrrhiza glabra root extract 0.3%th, giant knotweed root extract 0.3%, green-tea extract 0.3%, german chamomile flower extract 0.3%, radix scutellariae root extract 0.3%, Gotu Kola P.E 0.3, glycerol caprylate 0.2%, decoyl hydroximic acid 0.3%, surplus are water.
3. the acne eliminating cream according to claim 2 that there is prevention pockmark to generate, it is characterised in that:By following percentage by weight Raw material composition:Hydrolecithin 1.5%, laruyl alcohol phosphate potassium 0.3%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, Bisabolol 0.8%, isoflavones 0.5%, vitamin E 0.2%, dimethyl silicone polymer 1.0%, ethylenediamine tetra-acetic acid two Sodium 0.05%, glycerine 6.0%, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark are extracted Thing 0.5%, arhat cypress branch extract 0.5%, pummelo peel extract 0.5%, canaline 1.5%, glycyrrhiza glabra root extract 0.5%th, giant knotweed root extract 0.5%, green-tea extract 0.5%, german chamomile flower extract 0.5%, radix scutellariae root extract 0.5%, Gotu Kola P.E 0.8%, glycerol caprylate 0.2%, decoyl hydroximic acid 0.3%, surplus are water.
4. the acne eliminating cream according to claim 3 that there is prevention pockmark to generate, it is characterised in that:By following percentage by weight Raw material composition:Hydrolecithin 1.5%, laruyl alcohol phosphate potassium 0.3%, evening primrose oil 4.0%, cetostearyl alcohol 2.5%, Bisabolol 0.5%, isoflavones 0.35%, vitamin E 0.2%, dimethyl silicone polymer 1.0%, ethylenediamine tetra-acetic acid Disodium 0.05%, glycerine 6.0%, carbomer 0.2%, arginine 0.2%, Sodium Hyaluronate 0.05%, wrinkle leaf lily magnolia bark are carried Thing 0.4%, arhat cypress branch extract 0.4%, pummelo peel extract 0.4%, canaline 1.0%, glycyrrhiza glabra root is taken to extract Thing 0.4%, giant knotweed root extract 0.4%, green-tea extract 0.4%, german chamomile flower extract 0.4%, radix scutellariae root extract 0.4%th, Gotu Kola P.E 0.55%, glycerol caprylate 0.2%, decoyl hydroximic acid 0.3%, surplus are water.
CN201710302588.XA 2017-04-28 2017-04-28 A kind of acne eliminating cream that there is prevention pockmark to generate Pending CN107184448A (en)

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CN110721139A (en) * 2019-10-30 2020-01-24 广东密尚生物科技有限公司 Oil-controlling acne-removing composition and preparation method and application thereof
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CN108815031A (en) * 2018-07-16 2018-11-16 广东卓明仕生物科技有限公司 A kind of Chinese medicine composition fermentation magma and its preparation method and application
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CN108785243B (en) * 2018-08-15 2021-04-20 广州惜颜生物科技有限公司 Anti-aging whitening acne-removing cream and preparation method thereof
CN108969455A (en) * 2018-09-04 2018-12-11 广州鹰远生物科技有限公司 A kind of anti-acne moisture-keeping composition and its application containing viola mandshurica
CN109199962A (en) * 2018-11-09 2019-01-15 广州睿森生物科技有限公司 A kind of acne-removing composition and cosmetics
CN110721139A (en) * 2019-10-30 2020-01-24 广东密尚生物科技有限公司 Oil-controlling acne-removing composition and preparation method and application thereof
CN113812672A (en) * 2021-09-24 2021-12-21 任国涛 Electronic cigarette tobacco tar containing sodium hyaluronate and preparation method thereof

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