CN108498390B - Tibetan herbal extract for treating acne and preparation method and application thereof - Google Patents

Tibetan herbal extract for treating acne and preparation method and application thereof Download PDF

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CN108498390B
CN108498390B CN201710103830.0A CN201710103830A CN108498390B CN 108498390 B CN108498390 B CN 108498390B CN 201710103830 A CN201710103830 A CN 201710103830A CN 108498390 B CN108498390 B CN 108498390B
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tibetan
herbal extract
acne
tibetan herbal
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CN108498390A (en
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边巴次仁
白玛卓玛
索朗拉姆
旦增
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Tibetan Cheezheng Tibetan Medicine Co ltd
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Tibetan Cheezheng Tibetan Medicine Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/289—Vladimiria
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/41—Crassulaceae (Stonecrop family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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    • A61K36/898—Orchidaceae (Orchid family)
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract

The invention provides a Tibetan herbal extract for treating acne and a preparation method and application thereof, wherein the extract adopts Sichuan-xi parthenium, Hypericum erectum and herba Moslae dense flowers as raw material medicines so that the effects of the medicines generate synergistic action, thereby having the effects of preventing and treating acne on skin, and the extract also has the functions of antisepsis and sterilization. The Tibetan herbal extract can be prepared into cosmetics with various acceptable matrixes in the field of cosmetics, has mild effect on skin, and can play roles in relieving, repairing, diminishing inflammation, sterilizing and the like, so that the Tibetan herbal extract has good effects of preventing and treating acne, preserving and sterilizing.

Description

Tibetan herbal extract for treating acne and preparation method and application thereof
Technical Field
The invention belongs to the technical field of Tibetan medicines, and particularly relates to a Tibetan herbal extract for treating acne, and a preparation method and application thereof.
Background
Tibetan medicine is an important component of Chinese medicine, has long history, complete and profound theory, rich and full contents and thick Tibetan characteristics. On the basis of continuously absorbing the Chinese medicine theory, Tibetan medicine gradually develops into a complete traditional medicine with a theory, a method, a formula and a medicine, and the Tibetan medicine is a medical theory system which takes three reasons as a theory core, five sources as guidance ideas and takes seven substances, three filthy substances and physiological and pathological theories of liver meridians and collaterals as a basis. With the vigorous popularization of traditional Chinese medicine, the development of Tibetan medicine is gradually becoming mature.
The Tibetan herbal medicine is the plant medicine base of Tibetan medicine. The characteristic physiological characteristics and ecological characteristics of the Tibetan herbal medicine, namely, strong cold resistance and drought resistance, are endowed by the high-altitude, strong ultraviolet radiation plateau climate and rich pure land resources of the Tibetan herbal medicine (Tibetan medicine plants) grown in the broad Qinghai-Tibet plateau of China, and the characteristics of increased photosaturation point, decreased photosensation point, lower temperature adaptability, lower dark respiration rate and the like of the Tibetan herbal medicine in the process of adapting to the ecological environment with high, cold and low heat for a long time are benefited, so that the Tibetan herbal medicine is favorable for fully utilizing light energy, and the accumulation of dry matters in the Tibetan herbal medicine is favorable for increasing the contents of substances such as pectin, saccharides, hemicellulose and the like in cells of the Tibetan herbal medicine, thereby endowing the Tibetan herbal medicine with magical medical, skin care and health care effects. At present, aiming at the increasingly pursuing natural demands of skin care cosmetics in the aspects of oxidation resistance, aging resistance, antisepsis, inflammation diminishing and the like, the research and development of external treatment methods of Tibetan herbs have positive practical significance and important economic value.
Disclosure of Invention
The invention aims to provide a Tibetan herbal extract for treating acne.
The invention also aims to provide a preparation method of the Tibetan herbal extract for treating acne.
The invention also aims to provide application of the Tibetan herbal extract for treating acne in preparation of cosmetics.
Therefore, the technical scheme adopted by the invention for realizing the purpose is as follows:
the Tibetan herbal extract for treating acne comprises the following raw material medicines in parts by weight:
1-70 parts of Sichuan chrysanthemum indicum; 5-50 parts of fructus forsythia; 5-40 parts of elsholtzia densa.
Preferably, the crude drugs of the Tibetan herbal medicine extract for treating acne comprise the following components in parts by weight:
5-50 parts of Sichuan chrysanthemum indicum; 10-45 parts of fructus forsythia; 10-35 parts of elsholtzia densa; or
20-66 parts of Sichuan chrysanthemum indicum; 15-30 parts of fructus forsythia; 10-40 parts of elsholtzia densa.
More preferably, the crude drugs of the Tibetan herbal medicine extract for treating acne comprise the following components in parts by weight:
46 parts of Sichuan chrysanthemum indicum; 30 parts of fructus forsythia; and 24 parts of elsholtzia densa.
In order to make the effect of preventing and treating acne of the Tibetan herbal medicine extract more prominent, the Tibetan herbal medicine extract can further comprise one or more of the following raw material medicines on the basis of the formula:
5-35 parts of rhodiola rosea, 5-15 parts of lagotis, 5-40 parts of barberry bark, 5-25 parts of sinopodophyllum hexandrum, 5-70 parts of acorus calamus, 5-70 parts of scutellaria baicalensis, 5-15 parts of artemisia sieversiana, 5-15 parts of herba moslae, 5-15 parts of snow lotus herb, 5-15 parts of sea-buckthorn and 5-15 parts of elecampane.
The Sichuan-xi Heju, also called Sichuan-xi Qianlieguan, is a Tibetan medicine named as Yuguxing, recorded in Jingxi Qianlieguan and Shuanghuaqianlieguan, etc. Qinghai-Tibet plateau congeneric plants are used as the Tibetan medicine Yuguxinga Bao, and has the special effect of clearing heat and removing toxicity. The Chinese botanical record and the Tibetan herbal record have the effects of clearing away heat and toxic materials, treating sore, setting bone, clearing liver and gallbladder heat and the like, and inflorescence or whole herbs are used as medicines for mainly treating wound inflammation, swelling, acute conjunctivitis, dermatitis, sore furuncle, traumatic injury and other symptoms.
Herba Moslae with dense flower fragrance and containing vitamin A and vitamin B12Multiple effective components such as palmitic acid, oleic acid, linoleic acid, myristic acid and sitosterol, and has the effects of enriching and activating blood, and resisting bacteria and diminishing inflammation. It has effects in promoting blood circulation, promoting cell metabolism, inhibiting melanin pigmentation, and nourishing skin. Can be used as nutritional additive for cosmetics, and has effects in moistening skin, preventing skin dryness, whitening skin, and delaying skin aging.
Fructus forsythiae, named as 'Jiakuangwangqiu' in Tibetan language, has the effects of clearing away heat and toxic materials, dispelling wind and removing dampness, cooling blood and stopping bleeding, killing parasites, relieving itching, treating dermatitis and the like.
Rhodiola rosea is recorded in many books such as Shennong Ben Cao Jing, four medical classics, Jingzhu Ben Cao and Ben Cao gang mu. The rhodiola root has the special effects of resisting aging, resisting fatigue and anoxia, regulating immunity, regulating central nervous system, improving mental power, enhancing physical strength and the like.
Lagotis glauca, named Honglian in Tibetan language, is recorded by the Tibetan medicine book Jingzhu materia, and is bitter and cold in nature, and can clear away heat and toxic materials, promote blood circulation to regulate menstruation, calm adverse-rising energy and reduce blood pressure. Can be used for treating heat in the five internal organs, toxic heat in blood system, acute and chronic hepatitis, and menoxenia.
Cortex Berberidis Amurensis, dried endothelium of Berberis Amurensis of berberidaceae. Has effects of clearing away heat, relieving fever and toxic materials, and astringing yellow water.
Podophyllum hexandrum is a perennial herb of Sinopodophyllum of Podophyllum of berberidaceae, and has the effects of treating tinea, skin diseases, impetigo and the like by external application.
The vladimiria root is a Chinese herbal medicine preparation, is mainly used in cosmetics such as skin care products, whitening lotion, bath agent and the like in the field of cosmetics, can keep skin white and tender, moisten and smooth, has good functions of nourishing skin, preventing wrinkles and the like, and is an excellent skin acne treatment agent due to the bactericidal activity.
Baikal skullcap root, radix Scutellariae can be used to treat all kinds of skin diseases caused by damp-heat, such as dermatitis, eczema and erythema. Has anti-inflammatory and antiallergic effects. Can inhibit skin allergy and histamine skin reaction, and can reduce melanin generation when applied in whitening product. Has broad-spectrum antibacterial effect, and has different degrees of inhibition on various skin disease-treating fungi.
Rhizoma Acori Calami has antiinflammatory and antiviral effects. Can improve skin metabolism, increase capillary permeability, smooth rough skin, and prevent skin aging. It can also absorb ultraviolet ray, and has effects of inhibiting melanin formation, and can be used for treating acne, preventing acne, and preventing sunscreen cosmetic lotion and cream.
The artemisia sieversiana, a perennial herb, has great medicinal value in 107 kinds of sedum plants in the world, and is a rare medicinal plant; china mainly grows in high mountains with an altitude of more than 3500 m. Contains major components of Artemisia macrophylla glycoside and tyrosol, in addition, polyphenol, protein, fat, tannic acid, flavonoid compounds and microelement volatile oil, and microelements such as ferrum, zinc, tin, molybdenum, manganese, etc. Scientific research proves that: the artemisia sieversiana is superior to ginseng and acanthopanax senticosus in resisting anoxia, resisting fatigue, preventing acne, regulating immunity and other aspects.
Herba Moslae, Tibetan; cutting and protecting: the overground part of the Chinese medicinal composition can invigorate the stomach by oral administration and can treat skin itch by external application, which is seen in Qinghai-Tibet medicine identification. And 4, turning off the gentle race: branches, leaves and inflorescences of the current year are mainly used for treating anal diseases, fetal diseases, dermatosis and gastrointestinal diseases, and can be used for preventing insects and flies by external application, see Tibetan medicine of China. The whole plant can be used for treating dyspepsia and skin pruritus, as described in Dian province Zhi (Dian province).
Snow lotus, also known as saussurea involucrata, Tibetan name "Qiagao Suba", is a folk medicine commonly used by Tibetan. Related experiments show that the flavone in the snow lotus herb not only has the capabilities of removing free radicals and resisting oxidation, but also has the functions of inhibiting granulation tissue formation, relieving pain and diminishing inflammation. Preventing skin aging, resisting ultraviolet ray damage to skin, moistening, sterilizing, diminishing inflammation, and promoting granulation.
Seabuckthorn is a commercial crop with great development potential, and fruits, leaves, roots and seeds of seabuckthorn can be used as medicines. The effect of seabuckthorn is recorded in the book of Tibetan medicine of eight century of the Gongyuan, namely the Yue Wang dynasty, and modern researches show that a large amount of vitamin E, vitamin A, flavone and SOD active ingredients contained in seabuckthorn oil can effectively prevent free radicals, and simultaneously has the effects of inhibiting infection and inundation of propionibacterium acnes, repairing damaged skin and recovering normal renewal and circulation systems of the skin.
The preparation method of the Tibetan herbal extract for treating acne comprises the following steps:
the raw material medicines are crushed and extracted for 3-5 times by 0.5-50 times of extracting agent by weight, each time lasts for 0.5-2 hours, extracting solutions are combined, decolorized, concentrated to a relative density of 1.10-1.30, and then dried to obtain the traditional Chinese medicine composition.
Preferably, the weight ratio of the extracting agent to the bulk drug is 6-20.
Preferably, the extractant is prepared by mixing the following components in parts by weight:
400-600 parts of water; 400-600 parts of an organic solvent; 0-10 parts of a solubilizer;
0-25 parts of a surfactant; 0-5 parts of a defoaming agent; 0-50 parts of a permeation aid;
0-10 parts of a thickening agent; 0-15 parts of a tackifier.
Wherein, the organic solvent can be alcohols: such as methanol, ethanol, ethylene glycol, propylene glycol, glycerol, 1, 3-butylene glycol, benzyl alcohol, etc., preferably ethanol, propylene glycol, glycerol, 1, 3-butylene glycol;
the organic solvent may also be a ketone: such as acetone, butanone, etc.;
the organic solvent may also be an ether: such as diethyl ether, tetrahydrofuran, ethylene glycol monobutyl ether;
the organic solvent can also be selected from liquid oil esters: such as caprylic/capric triglyceride, ethyl acetate, C12～C16Benzoate, low viscosity synthetic oil (viscosity below 100 cps), liquid low viscosity ester (viscosity below 100 cps), preferably ethyl acetate, C12～C16Benzoate esters, caprylic capric triglyceride;
the organic solvent may also be a vegetable oil: such as olive oil, soybean oil, sesame oil, rapeseed oil, rice bran oil, rice germ oil, wheat germ oil, sea buckthorn oil, palm oil, linseed oil, avocado oil, peach kernel oil, carrot oil, Chinese gooseberry oil, grape seed oil, camellia oil, safflower oil, almond oil, clove oil, azalea oil, corn oil, vernonia oil, sunflower oil, peanut oil, hazelnut oil, shea oil, rose oil, cottonseed oil, camellia oil, and preferably azalea oil, sunflower oil, and safflower oil;
the organic solvent may also be a mineral oil: low boiling alkanes such as white oil, petroleum ether, kerosene, isododecane, isohexadecane, etc.;
the organic solvent may also be an aromatic compound: low boiling compounds such as toluene, ethylbenzene, etc.; or other classes of compounds or compositions: such as dimethyl sulfoxide, carbon disulfide and hydrogen peroxide.
The solubilizer can be selected from ethylene glycol monobutyl ether, benzyl alcohol, dimethyl sulfoxide and the like.
The above surfactant may be:
anionic surfactant: such as carboxylate, with the general formula RCOOM, wherein M represents metal ion, R is alkyl containing 11-17 carbon atoms; sulfonates; sulfate salts;
cationic surfactant: such as amine salts; quaternary ammonium salts; pyridine salts and the like;
nonionic surfactant: such as polyethylene glycol (PEG) or Polyoxyethylene (POE) types; polyhydric alcohol type and polymer surfactants;
amphoteric surfactant: such as betaines; amino acids; imidazolines, and the like.
The defoaming agent may be a polymer defoaming agent such as silicone oil.
The penetration enhancer may be inorganic salt such as sodium chloride, potassium chloride, zinc sulfate, sodium sulfate, etc.
The thickener may be lauryl alcohol, stearic acid, polyoxyethylene lauryl ether, etc.
The thickener may be sodium chloride, carbopol, polyethylene glycol distearate, lauric acid diethanolamide, etc.
The Tibetan herbal extract is combined with various acceptable substrates in the field of cosmetics to prepare cosmetics in various forms such as skin cream, skin lotion, smoothing toner, gel, essence, facial mask, hand cream, body cream, facial cleanser, aerosol, spray and the like according to the conventional process.
The invention relates to application of Tibetan herbal medicine extract for treating acne in preparation of cosmetics for treating acne.
Preferably, the content of the Tibetan herbal extract accounts for 0.3-10 wt% of the total mass of the cosmetic.
Preferably, the cosmetic is in the form of a cream, lotion, water, gel, mask, aerosol or spray.
Compared with the prior art, the technical scheme of the invention has the following advantages:
1. the Tibetan herbal extract for treating acne provided by the invention selects Sichuan-xi parthenium, Hypericum erectum and Mosla dens as raw material medicines, and the combination of the Tibetan herbal medicines enables the efficacies of the medicines to generate synergistic effect, so that the Tibetan herbal extract has the effects of preventing and treating acne on skin, and also has the functions of antisepsis and sterilization.
2. According to the preparation method of the Tibetan herbal medicine extract for treating acne provided by the invention, the extraction agent at least comprising water and an organic solvent is adopted to extract all the raw material medicines, so that active ingredients in the raw material medicines can be obtained to the maximum extent, and the effects of all the medicines can generate a synergistic effect, thereby ensuring that the obtained extract has good effects of preventing and treating acne. The preparation method is simple and convenient, has strong operability and is beneficial to industrial production.
3. The cosmetic containing the Tibetan herbal extract for treating acne provided by the invention has mild skin effect, and can play roles in relieving, repairing, diminishing inflammation, sterilizing and the like, so that the cosmetic has good effects of preventing and treating acne, preserving and sterilizing.
Detailed Description
The technical solutions of the present invention will be described clearly and completely below, and it should be apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
In the following examples and comparative examples, 1g represents 1 part by weight.
Example 1
Mixing and crushing 45g of Sichuan-xi hedyotis herb, 15g of Hypericum erectum, 10g of dense flower elsholtzia herb and 15g of Elsholtzia rugulosa, extracting for 4 times by using an extracting agent with the weight of the herb being 12 times, extracting for 1 hour each time, combining extracting solutions, decoloring to clear light yellow liquid by using a molecular sieve, concentrating to the relative density of 1.10, and drying to obtain the Tibetan herbal extract.
The extractant in the embodiment is prepared by mixing the following components: 500g of water, 500g of ethanol, 2g of salt, 5g of sodium dodecyl sulfate, 2g of silicone oil and 2g of lauryl alcohol.
Examples 2 to 12
The preparation method of the Tibetan herbal medicine extract in the examples 2-12 is similar to that in the example 1, but the raw material medicine composition, the extractant composition and the specific process parameters in each example are shown in the table 1.
TABLE 1 crude drug compositions, extractant compositions, and specific processing parameters for examples 2-12
Figure BDA0001232482460000081
Figure BDA0001232482460000091
Example 13
Mixing 3g of the Tibetan herbal extract prepared in the embodiment 3 of the invention with 10g of octadecanoic acid, 2g of triethanolamine, 2g of sodium hydroxide, 10g of glycerol and 0.5g of essence, adding deionized water into the mixture to 100g, and preparing the vanishing cream according to a conventional process.
Examples 14 to 20
The vanishing creams of examples 14-20 are prepared as in example 13, but with the only difference that the Tibetan herbal extracts used correspond in sequence to examples 4-10, respectively.
Example 21
Mixing 3g of the Tibetan herbal extract prepared in the embodiment 9 of the invention with 10g of octadecanoic acid, 2g of triethanolamine, 2g of sodium hydroxide, 10g of glycerol, 0.5g of essence and 0.5g of preservative, adding deionized water into the mixture to 100g, and preparing the vanishing cream according to a conventional process.
Example 22
Mixing 3g of the Tibetan herbal extract prepared in the embodiment 10 of the invention with 10g of octadecanoic acid, 2g of triethanolamine, 2g of sodium hydroxide, 10g of glycerol, 0.5g of essence and 0.5g of preservative, adding deionized water into the mixture to 100g, and preparing the vanishing cream according to the conventional process.
Comparative example 1
The comparative example was prepared in a similar manner to example 9 except that the crude drug was 46g of Hibiscus Sabdariffa.
Comparative example 2
The preparation method of the Tibetan herbal extract in the comparative example is similar to that of example 9, but the only difference is that the raw material medicines are 46g of Sichuan-xi parthenium and 30g of Hypericum erectum.
Comparative example 3
The preparation of the Tibetan herbal extract in this comparative example is similar to that of example 9, but the only difference is that the raw materials are 46g of Sichuan chrysanthemum and 24g of dense flower.
Experimental example 1 test of therapeutic effect on acne on back
Taking 5g of the extracts obtained in examples 1-12 and comparative examples 1-3 respectively, and diluting the extracts to 50g by using glycerol respectively for later use;
selecting 150 healthy volunteer subjects, evenly dividing into 15 groups of 10 persons in each group, wherein the ages of the 10 persons are 35 to 40 years, and the healthy volunteer subjects are all acne with the back of 2 persons per square centimeter;
the extract diluent is applied to 15 groups of subjects respectively, 2 times a day for 90 days, and only applied to the affected parts each time.
And (3) detection results: the tested population is checked after 90 days, the curative effect evaluation is comprehensively evaluated from 4 aspects of the number of acne lesions, the types of the lesions, the positions of the lesions and subjective symptoms, and specifically, the clinical cure is as follows: the skin lesion disappears, or only a little pigmentation is left, and the subjective symptoms disappear; the effect is shown: the skin lesion is mostly removed, and the subjective symptoms are obviously relieved; improvement: the skin lesion is partially removed, and subjective symptoms are improved; and (4) invalidation: the skin lesions do not fade significantly or are aggravated adversely. The total effective rate is clinical cure rate + significant efficiency + improvement rate.
In this experimental example, the total effective rate of the diluted solution coated with the extract obtained in examples 1 to 12 is 86 to 92%, wherein the total effective rates of examples 2, 4 and 9 can be respectively as high as 91%, 90% and 92%; while the facial acne of 30 subjects coated with the diluted solution of the extract obtained in the comparative examples 1 to 3 is slightly improved, the total effective rates of the comparative examples 1 to 3 are respectively 40%, 43% and 45%, and the curative effect of the example group is obviously better than that of the comparative example group.
The test result shows that the Tibetan herbal medicine extract has good effect of treating the acne on human skin.
Experimental example 2 testing of the treatment effect of facial acne
Taking 5g of the extracts obtained in examples 1-12 and comparative examples 1-3 respectively, and diluting the extracts to 50g by using glycerol respectively for later use;
selecting 150 patients with acne as subjects, dividing into 15 groups, each group comprises 10 patients with acne of 18-28 years old and 2 acne patients per square centimeter;
applying the extract diluent to the parts with acne on face of 15 groups of subjects respectively, wherein the application is carried out 2 times a day and 90 days;
and (3) detection results: the curative effect evaluation is comprehensively evaluated from 3 aspects of the number of the whelks, rash spots and scars of affected parts and subjective symptoms, and the whelks are cured clinically, the face has no rash spots and scars and the subjective symptoms disappear; has obvious effect that the acne of the affected part disappears or less than 2 acnes per square centimeter, a little pimple is left, and the subjective symptom is improved; and (4) invalidation: acne is not reduced, and affected part is not improved. The total effective rate is the clinical cure rate plus the significant efficiency.
In the experimental example, the facial acne of 120 subjects coated with the diluent of the extract obtained in the examples 1 to 12 of the invention improves to different degrees, the total effective rate of the experimental example is 88 to 95 percent, wherein the total effective rates of the examples 2, 4 and 9 can respectively reach 90 percent, 92 percent and 95 percent; while the facial acne of 30 subjects coated with the diluted solution of the extract obtained in the comparative examples 1 to 3 is slightly improved, the total effective rates of the comparative examples 1 to 3 are respectively 40%, 42% and 41%, and the curative effect of the example group is obviously better than that of the comparative example group.
Test results show that the Tibetan herbal medicine extract has a certain treatment effect on whelk.
Experimental example 3 acne prevention effect test
Taking 5g of the extracts obtained in examples 1-12 and comparative examples 1-3 respectively, and diluting the extracts to 50g with glycerol respectively for later use;
selecting 150 healthy volunteer subjects, dividing into 15 groups of 10 persons;
applying the extract diluent to 15 groups of subjects, 2 times a day for 66 days;
and (3) detection results: the curative effect evaluation is comprehensively evaluated from 3 aspects of whether acne appears or not, skin state and subjective symptom, the clinical effectiveness is that the existing acne disappears in the test period, new acne does not appear, and the skin is fine, smooth, glossy and good in elasticity compared with the skin before being smeared; the effect is obvious, most of the skin damage in the test period is removed, and new acne skin damage does not appear; improvement, namely, the skin lesion is partially removed, new acne skin lesion does not appear, and subjective symptoms are improved; no effect, no obvious regression of the skin lesion or new acne growth. The total effective rate is clinical effective rate + significant efficiency + improvement rate.
120 subjects who are smeared with the diluent of the extract obtained in the examples 1 to 12 of the invention in the experimental example have fine, glossy and good elasticity, and the total effective rate of the experimental example is 82 to 90 percent, wherein the total effective rates of the examples 2, 4 and 9 can respectively reach 85 percent, 87 percent and 90 percent; the 30 subjects coated with the diluted solution of the extract obtained in the comparative examples 1 to 3 have slightly improved skin types compared with the skin types before coating, the total effective rates of the comparative examples 1 to 3 are 43 percent, 45 percent and 45 percent respectively, and the curative effect of the example group is obviously better than that of the comparative example group (P < 0.01).
Test results show that the Tibetan herbal medicine extract has a good effect of preventing acne on human skin.
Experimental example 4 test of antiseptic and sterilizing effects
10 of each of the vanishing creams obtained in examples 13-22 of the present invention were added15E.coli and propionibacterium acnes for preservative challenge testing.
As a result, it was found that the vanishing creams prepared in examples 13-20 (without added preservatives) had no detectable microbes at day 7, whereas the vanishing creams prepared in examples 21-22 (with added preservatives) had no microbes counted at day 28.
The test result shows that the Tibetan herbal medicine extract has the effect of killing microorganisms.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.

Claims (10)

1. The Tibetan herbal extract for treating acne comprises the following raw material medicines in parts by weight:
1-70 parts of Sichuan chrysanthemum indicum; 5-50 parts of fructus forsythia; 5-40 parts of elsholtzia densa.
2. The Tibetan herbal extract for treating acne as set forth in claim 1,
5-50 parts of Sichuan chrysanthemum indicum; 10-45 parts of fructus forsythia; 10-35 parts of elsholtzia densa; or
20-66 parts of Sichuan chrysanthemum indicum; 15-30 parts of fructus forsythia; 10-40 parts of elsholtzia densa.
3. The Tibetan herbal extract for treating acne according to claim 1 or 2,
46 parts of Sichuan chrysanthemum indicum; 30 parts of fructus forsythia; and 24 parts of elsholtzia densa.
4. The Tibetan herbal extract for treating acne according to any one of claims 1 to 3, further comprising one or more of the following bulk drugs:
5-35 parts of rhodiola rosea, 5-15 parts of lagotis, 5-40 parts of barberry bark, 5-25 parts of sinopodophyllum hexandrum, 5-70 parts of acorus calamus, 5-70 parts of scutellaria baicalensis, 5-15 parts of artemisia sieversiana, 5-15 parts of herba moslae, 5-15 parts of snow lotus herb, 5-15 parts of sea-buckthorn and 5-15 parts of elecampane.
5. A method of preparing the Tibetan herbal extract for the treatment of acne as claimed in any one of claims 1 to 4, comprising the steps of:
the raw material medicines are crushed and extracted for 3-5 times by 0.5-50 times of extracting agent by weight, each time lasts for 0.5-2 hours, extracting solutions are combined, decolorized, concentrated to a relative density of 1.10-1.30, and then dried to obtain the traditional Chinese medicine composition.
6. The preparation method of the Tibetan herbal extract for treating acne as claimed in claim 5, wherein the weight ratio of the extracting agent to the bulk drug is 6-20.
7. The preparation method of the Tibetan herbal extract for treating acne as claimed in claim 5 or 6, wherein the extracting agent is prepared by mixing the following components in parts by weight:
400-600 parts of water; 400-600 parts of an organic solvent; 0-10 parts of a solubilizer;
0-25 parts of a surfactant; 0-5 parts of a defoaming agent; 0-50 parts of a permeation aid;
0-10 parts of a thickening agent; 0-15 parts of a tackifier.
8. Use of the Tibetan herbal extract for the treatment of acne as described in any one of claims 1 to 4 for the preparation of a cosmetic for the treatment of acne.
9. The use according to claim 8, wherein the Tibetan herbal extract is used in an amount of 0.3 to 10 wt% based on the total mass of the cosmetic.
10. The use according to claim 8 or 9, wherein the cosmetic formulation is a cream, lotion, water, gel, mask, aerosol or spray.
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