CN104784507A - Traditional Chinese medicine composition with multiple cosmetic effects and application - Google Patents
Traditional Chinese medicine composition with multiple cosmetic effects and application Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition with multiple cosmetic effects. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 5-40 parts of ginseng, 5-40 parts of cordyceps militaris, 5-40 parts of bird's nests, 5-40 parts of ganoderma, 5-40 parts of dendrobium officinale, 5-40 parts of roses, 2-35 parts of peony, 2-35 parts of saussurea involucrata, 2-35 parts of lavandula angustifolia, 1-35 parts of thymus mongolicus, 1-35 parts of rosa gallica, 1-35 parts of nymphaea caerulea savigny, 5-40 parts of mongolian milkvetch roots, 5-40 parts of dioscorea composite roots, 1-35 parts of peach blossom, 5-40 parts of polygonatum odoratum, 5-40 parts of ligusticum chuanxiong and 5-40 parts of magnolia sieboldii. The traditional Chinese medicine composition has the benefits that through the synergistic effect of all components in the composition, wrinkles and chromatosis are reduced, metabolism is promoted, and the skin is ruddy, white and supple.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specially and a kind of there is Chinese medicine composition of multiple beauty functions and its preparation method and application.
Background technology
Because current most of cosmetics are all containing a large amount of chemosynthesis materials, life-time service, not only can cause damage to human skin, and the serious physiological function that also can affect human body.People have been caused to worry for the permanence operations such as toxicity, zest and anaphylaxis that chemosynthesis material brings and safety problem.
Along with the development of cosmetic industry and the raising of living standards of the people, under the U.S. tide of back to nature drives, people propose new dimensions of quality and demand to beauty and make-up, start again to pursue nontoxic, the free of contamination natural cosmetics of nature.Because natural cosmetics safety is high, side effect is little, has diversified physiological function, more and more obtains the attention of people.Meet self to the demand of U.S. by becoming the focus of new period concern with green natural, being changed to natural product by chemosynthesis goods, is the leap again of cosmetic industry development.
As everyone knows, Chinese herbal medicine is the resource of China's preciousness, simultaneously the quintessence of Chinese culture of Ye Shi China, and having had the developing history of thousands of years in China, is bright jewel very important in Chinese civilization history.For the research and development of functional natural cosmetics, can using Chinese medical theory as instructing, following the Overall View of Traditional Chinese Medicine and dialectical opinion thought, and the principle of monarch and mass action, by the combination and compatibility of multiple active skull cap components, produce and coordinate compatibility effect, maximized performance active skull cap components effect.And much also possess tonic effect for having in the Chinese herbal medicine of beauty and skin care, and nontoxic and side effect, now its effect has been no longer simple skin protection or makeups, but can promote metabolism and the growth of human body integral, prevents skin aging.
Thus domestic increasingly active for the preparation of the research of cosmetics and cosmetics of everyday use to Chinese herbal medicine.Publication number is that the Chinese patent application file of CN104013566A discloses a kind of Chinese medicine composition, its preparation method and the cosmetic applications thereof with white-skinned face function.Publication number is that the Chinese patent document of CN102973937A discloses the compositions with beautifying skin effect and the oral cosmetic product comprising said composition.Publication number is that the Chinese patent application file of CN103027881A discloses a kind of cosmetics of everyday use with antibacterial beauty functions.Publication number is that the Chinese patent application file of CN102641214A discloses titanium phosphate and preparing the application in cosmetics.Publication number is that the Chinese patent application file of CN102378622A discloses whitening agent and makes the beauty method of skin-whitening.Publication number is that the Chinese patent application file of CN102008426A discloses a kind of cosmetic composition with effect of scavenging radical.Publication number is the cosmetic composition that the Chinese patent document of CN1833630A discloses containing fine and porous powder.Publication number is that the Chinese patent document of CN101014316A discloses after shave powder, its preparation method and comprises the make-up cosmetic composition of this after shave powder.Publication number is that the Chinese patent document of CN1593380A discloses a kind of beauty and skin care compositions, preparation method and application thereof.
By analysis, compositions disclosed in above patent is all only for a kind of or a few beauty functions, and the preparation method of most compositions also relative poor, major part is all heating extraction, does not carry out separation and purification, and obtained product impurity is many, poor stability, easily causes the shortcomings such as irritant reaction.In addition, a part of formula only has chemosynthesis active component, and the such product of life-time service easily has side effects; The beauty treatment mode that the formula of another part even adopts physics to hide, does not have maintenance skin at all and nourishes the effect of skin.
With advancing age and under the impact of the factors such as weather conditions, living environment, the mental status, health status, bad living habit, skin is easily caused to produce the aging phenomenons such as aging, loose, wrinkle, pigmentation.Therefore, a formula possessing defying age, prevent pigmentation, increase many-sided effects such as skin elasticity consider that when designing effect is worked in coordination with enhancement effect and just reached comprehensive comprehensive cosmetic result.
Described formula mainly contains following seven ergonomics to be needed to consider when designing:
(1) scavenging free radicals, stops the destruction of radical pair human body cell, and delaying skin tissue is old and feeble.
(2) compact skin, desalination wrinkle.
(3) containing moisturizing active component, prevent skin from becoming dry, make skin keep normal wetting state, promote release and the Transdermal absorption of active matter, guarantee that active component arrives lesions position fast.
(4) provide nutritional labeling to skin, repair impaired skin.Strengthen skin resistance, Antagonistic Environment stimulates simultaneously, and prevention is responsive.
(5) desalinate color class, reduce pigmentation, allow skin keep bright even with the colour of skin.
(6) promote skin blood supply, accelerate local blood circulation, improve skin color and luster.
(7) enhance metabolism, remove aging cutin, promote that skin is newborn, give skin vigor.
Summary of the invention
The present invention is directed to the deficiencies in the prior art part, there is provided a kind of pure Chinese medicine, non-stimulated, without hormone, antibiotic-free, have and absorb ultraviolet, scavenging free radicals, lasting moisturizing, repair skin, the skin that compacts, desalination wrinkle, antiallergic antiinflammatory, defying age, improve skin histology metabolism, promote cutaneous circulation, increase skin supplement ingredient, allow skin present Chinese medicine composition that ruddy tender white and high resilience etc. have multiple beauty functions.
There is described in the second object of the present invention is to provide the preparation method of the Chinese medicine composition of multiple beauty functions.
There is described in the third object of the present invention is to provide the application of the Chinese medicine composition of multiple beauty functions.
For solving above-mentioned technical problem, Chinese medicine composition of the present invention adopts following technical scheme:
Have the Chinese medicine composition of multiple beauty functions, it is made up of the 18 kinds of pure natural raw materials comprising following parts by weight: Radix Ginseng 5 ~ 40, Cordyceps militaris (L.) Link. 5 ~ 40, Nidus collocaliae 5 ~ 40, Ganoderma 5 ~ 40, Herba Dendrobii 5 ~ 40, Flos Rosae Rugosae 5 ~ 40, Flos Moutan 2 ~ 35, Herba Saussureae Involueratae 2 ~ 35, lavandula angustifolia 2 ~ 35, Herba thymi vulgaris 1 ~ 35, french rose spend 1 ~ 35, Egyptian blue oral shui solution 1 ~ 35, Radix Astagali root 5 ~ 40, dioscorea mexicana root 5 ~ 40, Flos persicae 1 ~ 35, Rhizoma Polygonati Odorati 5 ~ 40, Rhizoma Chuanxiong 5 ~ 40, Magnolia sieboldii 5 ~ 40.
The described Chinese medicine composition with multiple beauty functions be above-mentioned each component extracted separately, filter, be separated, carry out after concentrated or drying composite, also can be by carrying out again after the mixing of each component extracting, filter, be separated, concentrated or drying and other steps makes, and obtains concentrated solution, thick paste or powder.
The described preparation method with the Chinese medicine composition of multiple beauty functions, it step comprised is as follows:
(1) pretreatment of raw material: respectively Radix Ginseng, Cordyceps militaris (L.) Link., Nidus collocaliae, Ganoderma, Herba Dendrobii, Flos Rosae Rugosae, Flos Moutan, Herba Saussureae Involueratae, lavandula angustifolia, Herba thymi vulgaris, french rose flower, Egyptian blue oral shui solution, Radix Astagali root, dioscorea mexicana root, Flos persicae, Rhizoma Polygonati Odorati, Rhizoma Chuanxiong, Magnolia sieboldii Chinese crude drug component are chosen and picked up, remove impurity, then Chinese Pharmacopoeia test sieve 10 ~ 100 object powder is ground into, then mix homogeneously;
(2) extract and filter: the component through pulverizing is thrown in extraction pot, add water or C1 ~ C3 lower alcohol solvent of component weight 1 ~ 50 times, extract 1 ~ 3 time under 5 ~ 100 DEG C of conditions, each extraction time is 10 ~ 180min, then will extract material to filter, or centrifugal, or the mode of squeezing collects clear filtrate;
(3) microfiltration: clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining 0.1 ~ 1 μm, aperture micro-filtration membrane, obtaining micro-filtrate;
(4) ultrafiltration: the ultrafilter membrane of micro-filtrate molecular cut off 5000 ~ 30000Da is carried out ultrafiltration, the impurity such as removing macromole pigment, tannin, obtain ultrafiltrate;
(5) nanofiltration: the film of receiving of ultrafiltrate molecular cut off 80 ~ 300Da being carried out nanofiltration, except anhydrating or C1 ~ C3 lower alcohol solvent, obtaining nanofiltration liquid;
(6) concentrated or dry: nanofiltration liquid to be concentrated, obtains concentrated solution or thick paste, or thick paste is dried to pressed powder.
Preferably, the Extracting temperature of step (2) is 20 ~ 40 DEG C, and extraction time is 30 ~ 60min.
Preferably, the aperture of the micro-filtration membrane of step (3) is 0.2 ~ 0.6 μm.
Preferably, the molecular cut off of the ultrafilter membrane of step (4) is 8000 ~ 20000Da.
Preferably, the molecular cut off of the NF membrane of step (5) is 100 ~ 200Da.
The described Chinese medicine composition with multiple beauty functions may be used in cosmetics, and its addition is 0.5 ~ 20%.Cosmetics comprise water preparation, gel, unguentum, cream, emulsion, facial film etc.
The described Chinese medicine composition with multiple beauty functions also can be aided with the medicine etc. that suitable adjuvant is prepared into food, beverage, health product or oral formulations, detergent.
Compared with prior art, the present invention has following beneficial effect: pharmaceutical formulation prescription is exquisite, can at multiple target spot, and many aspects play complete beautification effect: wherein, Radix Ginseng, Radix Astagali root and Rhizoma Chuanxiong grass has the effect of good blood circulation promoting, can improve the colour of skin; Cordyceps militaris (L.) Link. and Nidus collocaliae can increase skin-nourishing, stimulate the division of various kinds of cell to increase Zhi, make skin smooth tender; Ganoderma and Herba thymi vulgaris have raising human body immunity; Herba Dendrobii and french rose flower have the effect of efficiently locking water, long-acting moisturizing, make skin keep normal wetting state, promote release and the Transdermal absorption of active matter; Flos Rosae Rugosae, Flos Moutan and Herba Saussureae Involueratae have the effect promoting skin metabolism, the pigmentation that goes down, desalination facial colour spot; Egyptian blue oral shui solution, Flos persicae and Magnolia sieboldii have the effect removing skin free radical fast, can effectively desalinate wrinkle and slow down aging; Lavandula angustifolia, dioscorea mexicana root, Rhizoma Polygonati Odorati have promotion cell regeneration, strengthen skin self-regeneration and opposing environmental stimuli ability, can improve dry and cracked rough skin situation, make it soft lubrication.By the synergism that component each in compositions is mutual, effects such as reaching desalination wrinkle, reduce pigmentation, enhance metabolism, makes skin present the multiple beauty functions such as ruddy tender white also high resilience.In addition, both removed the impurity such as large diameter thalline, suspended solid by micro-filtration membrane, and again with impurity such as ultrafilter membrane removing macromole pigment, tannins, made the product stability for preparing high, not easily cause irritant reaction.
Accompanying drawing explanation
Fig. 1 is Hydroxyl radical-scavenging experimental result column schematic diagram;
Fig. 2 is moistening effect test experiments result curve schematic diagram;
Fig. 3 is the photo that EDU cell proliferation test experience result is in the cell of vegetative state;
Fig. 4 is the photo of the cell of EDU cell proliferation test experience result survival.
Specific embodiment
In order to set forth content of the present invention better, be described with some preferably specific embodiments below.
Principle explanation
Each component effect of formula of the present invention is as follows:
Radix Ginseng: the dry root of Araliaceae Radix Ginseng.Property flat, sweet in the mouth, micro-hardship, tepor.It is containing multiple Saponin and polysaccharide composition, and energy skin expansion blood capillary, promotes cutaneous circulation, increase skin-nourishing, the water oil balance of regulation of skin, prevent skin dehydration, sclerosis, wrinkling, adhere to for a long time using the product containing Radix Ginseng, can skin elasticity be strengthened, cell is obtained newborn.Radix Ginseng active substance also has the reducing property of check melanin simultaneously, makes skin pure white smooth.
Cordyceps militaris (L.) Link.: Clavicipitaceae fungus Cordyceps militaris (L.) Link. colonizes in Stroma on Hepialidae insecticide Hepialus armorieanus Oberthur larva and larva cadaveric complex.Sweet in the mouth, property is put down.Its people contains cordycepin, cordycepic acid, polysaccharide, aminoacid, polypeptide, nucleic acid and vitamin, superoxide dismutase (SOD) isoreactivity composition, and it can increase immune system cell, organize quantity, and enhancing antibody produces, and strengthens body immunity.Simultaneously can also scavenging free radicals, antioxidation, enhances metabolism, thus plays the effect of slow down aging.
Nidus collocaliae: the nest nest built up with condensation by mixings such as salivas for Apodidae animal esculent swift, it contains epidermal growth factor and cell division hormone, and it can stimulate the division of various kinds of cell to increase Zhi.Promote cell differentiation, carry out stopping again fast to damaged skin, promote the healing of surgical wound and wound surface.Improve the sophistication of human body skin, the cell of ageing skin can be started, make skin become smooth and flexible.
Ganoderma: the Herb of Polyporaceae plant Ganoderma lucidum (Leyss. Ex Fr.) Karst. or Ganoderma.Main component comprises ganoderan, Ganoderma polypeptide, triterpenes, 16 seed amino acids, protein isoreactivity composition, and it regulates metabolic balance, promotes the synthesis of nucleic acid and protein, and can increase the division algebraically of cell.There is the perfect of Promote immunity function simultaneously, strengthen resistance against diseases, significantly can remove the free radical that body produces, thus stop the damage of radical pair body, prevent the peroxidating of fat body, therefore effectively can delay the aging of body.
Herba Dendrobii: belong to micro-specific item, the perennial herbaceous plant that grows nonparasitically upon another plant of the orchid family.Main component is dendrobium polysaccharide, dendrobine, dendrophnol, dendramine, 18 seed amino acids, also containing several mineral materials such as calcium, ferrum, zinc, selenium, potassium, magnesium, sodium, there is antitumor, regulate the effects such as immunity of organisms, reinforcing stomach reg fluid, nourishing YIN and clearing away heat, human body SOD level can be significantly improved, in scavenging free radicals, antioxidation, defying age, radioprotective etc., have remarkable efficacy.
Flos Rosae Rugosae: the flower of rosaceous plant Flos Rosae Rugosae and polyphyll Flos Rosae Rugosae, sweet and slightly bitter taste, warm in nature.Be rich in the multiple aroma volatile such as the multiple nutritional components such as vitamin C, xylose, glucose, sucrose, malic acid and geraniol, nerol, phenethanol, citronellol.Promote skin metabolism, can go down pigment, makes skin exquisiteness delicate.To treatment chloasma faciei, acne, acne, there is certain effect, skin of face can be made smooth tender.
Flos Moutan, the flower of ranunculaceae peony.Main component is Radix Paeoniae florigen-3,5 diglucosides, Radix Paeoniae florigen-3 glucoside, cyanidin-3,5 diglucosides, cyanidin-3 glucoside, pelargonin-3, the anthocyanidins such as 5 diglucosides, pelargonin-3 glucoside, and several amino acids and vitamin, there is the regulating liver-QI that nourishes blood, loose strongly fragrant blood stasis dispelling, make that QI and blood is abundant, appearance is ruddy, the effect of the desalination aspect such as chloasma faciei and delay skin aging.
Herba Saussureae Involueratae: Compositae herbaceos perennial.Containing volatile oil, alkaloid, flavonoid, phenols, saccharide, tannin isoreactivity composition, have restore menstrual flow and invigorate blood circulation, the effect such as dispelling cold and removing dampness, hemostasia and detumescence, isostere endotoxin.It can accelerate the metabolism of skin, reduces wrinkle, makes skin keep gloss, plentiful, slow down aging.In addition, good curative effect is had to facial freckle, chloasma hepaticum etc.
Lavandula angustifolia: the plant belonging to fruticuli or brushwood, main component is linalool, linalyl acetate, lavandulol, farnesene, epoxy caryophyllene etc.It can promote cell regeneration, accelerating wound healing, improves acne, balance sebum secretion.Rapid permeability skin, shrinkage expansion pore, promotes skin metabolism, Bergamot Mint Extract, improves many-sided cosmetic results such as the lock outlet capacity of skin.
Herba thymi vulgaris: a kind of growth is the fragrant herbaceous plant of low altitude area, and main component is the multiple compounds such as thymol, carvacrol, linalool and cymol.Many-sided effects such as there is blood circulation promoting, enhancing immunity, alleviate neuropathic pain, be antibacterial.
The Flos rosae multiflorae, the French especially Flos rosae multiflorae, french rose flower is the flower of french rose section plant sweetbrier polyantha, cool in nature, sweet in the mouth.Main component is geraniol, cephrol and astragaloside, flavone and polysaccharide etc., has efficiently to lock water, long-acting moisturizing, delay effect of various aging sign.
Egyptian blue oral shui solution: the dry flower of Nymphaeceae Nymphaea perennial aquatic herbaceous plant Egyptian blue Flos nymphaeae (Nymphaea teragona Georgi), main component has the composition such as alkaloid, polyphenol, effectively can resist and cause aging and free radical that is wrinkle.
Radix Astagali root: be the root of dicotyledon medicine leguminous plant Radix Astagali, mainly containing astragalus polysaccharides, astragaloside and multiple flavones ingredient, has Glycerin, skin maintenance, QI and blood regulating, the effect of emotion of releiving.
Dioscorea mexicana root: (English name Dioscorea composita Hemsl) Dioscoreaceae is wound around liana, containing dioscin, Christian Dior phenol, and various trace elements, the ability of skin self-regeneration and opposing environmental stimuli can be strengthened, reach anti-ageing effect by regulation of skin metabolism.
Flos persicae: the flower that rosaceous plant peach tree is in full bloom, main component is the compositions such as Rhizoma Kaempferiae acid, coumarin, trifolin, naringenin, vitamin, there is blood vessel dilating, promotion of blood circulation, moist skin, effect of improving blood circulation, promoting skin-nourishing and oxygen supply, thus can effectively prevent chloasma, freckle, black speck, reach effect of whitening and speckle dispelling.
Rhizoma Polygonati Odorati: the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati, main component contains the steroids such as Rhizoma Polygonati Odorati mucopolysaccharide, vitamin A, Rhizoma Polygonati spiral shell sterol, has effect of nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Dry and cracked, rough skin situation can be improved, make it soft lubrication, play the effect of beauty and skin care.
Rhizoma Chuanxiong: the rhizome of samphire Rhizoma Chuanxiong, sweet in the mouth, pungent, warm in nature.Mainly contain the chemical compositions such as alkaloid, ferulic acid, cnidium lactone, its extract has good regulating action to microcirculqtory system, has stronger restraint to the activity of some pathogenic dermatophytes.In addition, can also the activity of restraint of tyrosinase, thus can therapeutical effect be played to black speck, freckle, senile plaque.
Magnolia sieboldii: Magnoliaceae magnolia, the magnolol contained, vitamin, calcium, fiber and several amino acids, there is effect of the aspects such as moisturizing, moisturizing, antioxidation, relieving heat toxin, reparation skin damage cell, can fast-falling pox scar, desalination pox print, bright color, smooth microgroove, improve lubrication elasticity youth skinfeel.
Chinese medicine composition of the present invention has following beneficial effect:
Adopt pure natural raw material, have no side effect, each component Synergistic, can play comprehensively and significant cosmetic result.Such as Radix Ginseng, Radix Astagali root and Rhizoma Chuanxiong grass has the effect of good blood circulation promoting, can improve the colour of skin; Cordyceps militaris (L.) Link. and Nidus collocaliae can increase skin-nourishing, stimulate the division of various kinds of cell to increase Zhi, make skin smooth tender; Ganoderma and Herba thymi vulgaris have raising human body immunity; Herba Dendrobii and french rose flower have the effect of efficiently locking water, long-acting moisturizing, make skin keep normal wetting state, promote release and the Transdermal absorption of active matter; Flos Rosae Rugosae, Flos Moutan and Herba Saussureae Involueratae have the effect promoting skin metabolism, the pigmentation that goes down, desalination facial colour spot; Egyptian blue oral shui solution, Flos persicae and magnolia parviflora have the effect removing skin free radical fast, can effectively desalinate wrinkle and slow down aging; Lavandula angustifolia, dioscorea mexicana root, Rhizoma Polygonati Odorati have promotion cell regeneration, strengthen skin self-regeneration and opposing environmental stimuli ability, can improve dry and cracked rough skin situation, make it soft lubrication.The recipe design of Mutiple Targets brings the double effects not only taking stopgap measures but also effect a permanent cure.
Embodiment 1
Have the Chinese medicine composition of multiple beauty functions, it is made up of the 18 kinds of pure natural raw materials comprising following parts by weight: Radix Ginseng 6, Cordyceps militaris (L.) Link. 6, Nidus collocaliae 6, Ganoderma 6, Herba Dendrobii 7, Flos Rosae Rugosae 7, Flos Moutan 3, Herba Saussureae Involueratae 4, lavandula angustifolia 3, Herba thymi vulgaris 2, french rose spends 2, Egyptian blue oral shui solution 3, Radix Astagali root 6, dioscorea mexicana root 7, Flos persicae 3, Rhizoma Polygonati Odorati 7, Rhizoma Chuanxiong 7, Magnolia sieboldii 7.
Embodiment 2
Have the Chinese medicine composition of multiple beauty functions, it is made up of the 18 kinds of pure natural raw materials comprising following parts by weight: Radix Ginseng 39, Cordyceps militaris (L.) Link. 38, Nidus collocaliae 39, Ganoderma 39, Herba Dendrobii 38, Flos Rosae Rugosae 37, Flos Moutan 34, Herba Saussureae Involueratae 34, lavandula angustifolia 34, Herba thymi vulgaris 34, french rose spends 33, Egyptian blue oral shui solution 33, Radix Astagali root 38, dioscorea mexicana root 38, Flos persicae 34, Rhizoma Polygonati Odorati 37, Rhizoma Chuanxiong 37, Magnolia sieboldii 38.
Embodiment 3
There is the Chinese medicine composition of multiple beauty functions, it is made up of the 18 kinds of pure natural raw materials comprising following parts by weight: Radix Ginseng 10 ~ 30, Cordyceps militaris (L.) Link. 10 ~ 30, Nidus collocaliae 10 ~ 30, Ganoderma 10 ~ 30, Herba Dendrobii 10 ~ 30, Flos Rosae Rugosae 10 ~ 30, Flos Moutan 8 ~ 25, Herba Saussureae Involueratae 8 ~ 25, lavandula angustifolia 6 ~ 25, Herba thymi vulgaris 5 ~ 23, french rose spends 5 ~ 25, Egyptian blue oral shui solution 5 ~ 25, Radix Astagali root 10 ~ 30, dioscorea mexicana root 10 ~ 30, Flos persicae 8 ~ 25, Rhizoma Polygonati Odorati 10 ~ 30, Rhizoma Chuanxiong 10 ~ 30, Magnolia sieboldii 10 ~ 30.
Embodiment 4
Have the Chinese medicine composition of multiple beauty functions, it is made up of the 18 kinds of pure natural raw materials comprising following parts by weight: Radix Ginseng 11, Cordyceps militaris (L.) Link. 11, Nidus collocaliae 14, Ganoderma 16, Herba Dendrobii 12, Flos Rosae Rugosae 13, Flos Moutan 20, Herba Saussureae Involueratae 15, lavandula angustifolia 12, Herba thymi vulgaris 7, french rose spends 8, Egyptian blue oral shui solution 10, Radix Astagali root 21, dioscorea mexicana root 20, Flos persicae 15, Rhizoma Polygonati Odorati 18, Rhizoma Chuanxiong 19, Magnolia sieboldii 18.
The above-mentioned preparation method with the Chinese medicine composition of multiple beauty functions, it step comprised is as follows:
(1) pretreatment of raw material: respectively Radix Ginseng, Cordyceps militaris (L.) Link., Nidus collocaliae, Ganoderma, Herba Dendrobii, Flos Rosae Rugosae, Flos Moutan, Herba Saussureae Involueratae, lavandula angustifolia, Herba thymi vulgaris, french rose flower, Egyptian blue oral shui solution, Radix Astagali root, dioscorea mexicana root, Flos persicae, Rhizoma Polygonati Odorati, Rhizoma Chuanxiong, Magnolia sieboldii Chinese crude drug component are chosen and picked up, remove impurity, then Chinese Pharmacopoeia test sieve 20 ~ 80 object powder is ground into, then mix homogeneously;
(2) extract and filter: throwing in extraction pot by the component through pulverizing, adding water or C1 ~ C3 lower alcohol solvent of component weight 5 ~ 30 times, extract 1 ~ 3 time under 10 ~ 70 DEG C of conditions, each extraction time is 30 ~ 150min; Then will extract material to filter, or centrifugal, or the mode of squeezing collects clear filtrate.Preferably, Extracting temperature is wherein 25 ~ 35 DEG C, and extraction time is 40 ~ 50min.
(3) microfiltration: clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining aperture 0.2 ~ 0.8um micro-filtration membrane, obtaining micro-filtrate; Preferably, the aperture of described micro-filtration membrane is 0.3 ~ 0.6 μm.
(4) ultrafiltration: the ultrafilter membrane of micro-filtrate molecular cut off 6000 ~ 25000Da is carried out ultrafiltration, the impurity such as removing macromole pigment, tannin, obtain ultrafiltrate; Preferably, the molecular cut off walking described ultrafilter membrane is 10000 ~ 15000Da.
(5) nanofiltration: the film of receiving of ultrafiltrate molecular cut off 90 ~ 250Da being carried out nanofiltration, except anhydrating or C1 ~ C3 lower alcohol solvent, obtaining nanofiltration liquid; Preferably, the molecular cut off of described NF membrane is 120 ~ 200Da.
(6) concentrated or dry: nanofiltration liquid to be concentrated, obtains concentrated solution or thick paste, or thick paste is dried to pressed powder.Wherein, dry preferably spray drying.
Described C1 ~ C3 lower alcohol solvent can methanol or ethanol.
Embodiment 5
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: Radix Ginseng 100g, Cordyceps militaris (L.) Link. 100g, Nidus collocaliae 80g, Ganoderma 50g, Herba Dendrobii 50g, Flos Rosae Rugosae 50g, Flos Moutan 30g, Herba Saussureae Involueratae 30g, lavandula angustifolia 30g, Herba thymi vulgaris 30g, french rose flower 50g, Egyptian blue oral shui solution 30g, Radix Astagali root 50g, dioscorea mexicana root 50g, Flos persicae 50g, Rhizoma Polygonati Odorati 80g, Rhizoma Chuanxiong 80g, Magnolia sieboldii 60g.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the purified water of 25kg at every turn, stir extraction 2 times at ambient temperature, each extraction time is 0.5h, extracts material and processes collection clear filtrate after filtration.Above-mentioned clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining 0.5 μm, aperture micro-filtration membrane, carrying out ultrafiltration with molecular cut off 10000Da ultrafilter membrane after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving of molecular cut off 200Da.The nanofiltration concentrated solution vaporizer obtained is concentrated into 2000g, obtains present composition extracting solution.
Embodiment 6
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: Radix Ginseng 150g, Cordyceps militaris (L.) Link. 100g, Nidus collocaliae 80g, Ganoderma 50g, Herba Dendrobii 30g, Flos Rosae Rugosae 50g, Flos Moutan 30g, Herba Saussureae Involueratae 10g, lavandula angustifolia 30g, Herba thymi vulgaris 30g, french rose flower 50g, Egyptian blue oral shui solution 30g, Radix Astagali root 70g, dioscorea mexicana root 50g, Flos persicae 50g, Rhizoma Polygonati Odorati 50g, Rhizoma Chuanxiong 80g, Magnolia sieboldii 60g.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, and be then placed in extraction pot, add the purified water of 30kg, stir extraction 1 time under 60 DEG C of conditions, extraction time is 3h, extracts material and processes collection clear filtrate after filtration.Being that 0.5 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carrying out ultrafiltration with the ultrafilter membrane that molecular cut off is 8000Da after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving that molecular cut off is 100Da.By the nanofiltration concentrated solution spraying dry obtained, obtain the powder 200g of Chinese medicine composition of the present invention.
Embodiment 7
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: Radix Ginseng 50g, Cordyceps militaris (L.) Link. 150g, Nidus collocaliae 100g, Ganoderma 30g, Herba Dendrobii 50g, Flos Rosae Rugosae 50g, Flos Moutan 50g, Herba Saussureae Involueratae 30g, lavandula angustifolia 30g, Herba thymi vulgaris 10g, french rose flower 20g, Egyptian blue oral shui solution 50g, Radix Astagali root 70g, dioscorea mexicana root 50g, Flos persicae 80g, Rhizoma Polygonati Odorati 50g, Rhizoma Chuanxiong 80g, Magnolia sieboldii 50g.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the purified water of 10kg at every turn, under 80 DEG C of conditions, stir extraction 2 times, each extraction time is 1h, extracts material and processes collection clear filtrate after filtration.Be that 0.5 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carry out ultrafiltration with the ultrafilter membrane of molecular cut off 10000Da after obtaining micro-filtrate, the film of receiving of molecular cut off 100Da carries out nanofiltration.The nanofiltration concentrated solution vaporizer obtained is concentrated into 350g, obtains the thick paste of the present composition.
Embodiment 8
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 33%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 12%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 1%, french rose spends 1%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 1%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C1 lower alcohol solvent of 1kg at every turn, under 40 DEG C of conditions, stir extraction 3 times, each extraction time is 0.2h, extracts material and processes collection clear filtrate after filtration.Above-mentioned clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining 0.2 μm, aperture micro-filtration membrane, carrying out ultrafiltration with molecular cut off 6000Da ultrafilter membrane after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving of molecular cut off 150Da.The nanofiltration concentrated solution vaporizer obtained is concentrated into 2000g, obtains present composition extracting solution.
Embodiment 9
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 28%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 1%, french rose spends 1%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 1%, Rhizoma Polygonati Odorati 14%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, and be then placed in extraction pot, add the purified water of 10kg, stir extraction 1 time under 50 DEG C of conditions, extraction time is 0.25h, extracts material and processes collection clear filtrate after filtration.Being that 0.3 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carrying out ultrafiltration with the ultrafilter membrane that molecular cut off is 5000Da after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving that molecular cut off is 80Da.By the nanofiltration concentrated solution spraying dry obtained, obtain the powder 200g of Chinese medicine composition of the present invention.
Embodiment 10
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 38%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 3%, Herba thymi vulgaris 1%, french rose spends 2%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 1%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the purified water of 20kg at every turn, under 20 DEG C of conditions, stir extraction 2 times, each extraction time is 2.5h, extracts material and processes collection clear filtrate after filtration.Be that 1 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carry out ultrafiltration with the ultrafilter membrane of molecular cut off 20000Da after obtaining micro-filtrate, the film of receiving of molecular cut off 300Da carries out nanofiltration.The nanofiltration concentrated solution vaporizer obtained is concentrated into 350g, obtains the thick paste of the present composition.
Embodiment 11
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 3%, Herba thymi vulgaris 3%, french rose spends 3%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 1%, Rhizoma Polygonati Odorati 35%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C3 lower alcohol solvent of 10kg at every turn, under 5 DEG C of conditions, stir extraction 3 times, each extraction time is 1.5h, extracts material and processes collection clear filtrate after filtration.Above-mentioned clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining 0.1 μm, aperture micro-filtration membrane, carrying out ultrafiltration with molecular cut off 25000Da ultrafilter membrane after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving of molecular cut off 250Da.The nanofiltration concentrated solution vaporizer obtained is concentrated into 2000g, obtains present composition extracting solution.
Embodiment 12
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 1%, french rose spends 7%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 30%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, and be then placed in extraction pot, add the purified water of 30kg, stir extraction 1 time under 30 DEG C of conditions, extraction time is 3h, extracts material and processes collection clear filtrate after filtration.Being that 0.5 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carrying out ultrafiltration with the ultrafilter membrane that molecular cut off is 8000Da after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving that molecular cut off is 100Da.By the nanofiltration concentrated solution spraying dry obtained, obtain the powder 200g of Chinese medicine composition of the present invention.
Embodiment 13
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 1%, french rose spends 2%, Egyptian blue oral shui solution 30%, Radix Astagali root 6%, dioscorea mexicana root 5%, Flos persicae 5%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C2 lower alcohol solvent of 10kg at every turn, under 25 DEG C of conditions, stir extraction 2 times, each extraction time is 0.5h, extracts material and processes collection clear filtrate after filtration.Be that 0.6 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carry out ultrafiltration with the ultrafilter membrane of molecular cut off 6000Da after obtaining micro-filtrate, the film of receiving of molecular cut off 100Da carries out nanofiltration.The nanofiltration concentrated solution vaporizer obtained is concentrated into 350g, obtains present composition thick paste.
Embodiment 14
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 1%, french rose spends 15%, Egyptian blue oral shui solution 12%, Radix Astagali root 8%, dioscorea mexicana root 12%, Flos persicae 1%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C2 lower alcohol solvent of 5kg at every turn, stir extraction 3 times at ambient temperature, each extraction time is 1h, extracts material and processes collection clear filtrate after filtration.Above-mentioned clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining 0.3 μm, aperture micro-filtration membrane, carrying out ultrafiltration with molecular cut off 5000Da ultrafilter membrane after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving of molecular cut off 150Da.The nanofiltration concentrated solution vaporizer obtained is concentrated into 2000g, obtains present composition extracting solution.
Embodiment 15
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 13%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 14%, Herba thymi vulgaris 1%, french rose spends 1%, Egyptian blue oral shui solution 1%, Radix Astagali root 7%, dioscorea mexicana root 5%, Flos persicae 14%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, and be then placed in extraction pot, add the purified water of 40kg, stir extraction 1 time under 40 DEG C of conditions, extraction time is 2.5h, extracts material and processes collection clear filtrate after filtration.Being that 0.2 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carrying out ultrafiltration with the ultrafilter membrane that molecular cut off is 20000Da after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving that molecular cut off is 200Da.By the nanofiltration concentrated solution spraying dry obtained, obtain the powder 200g of Chinese medicine composition of the present invention.
Embodiment 16
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 35%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 3%, Herba thymi vulgaris 3%, french rose spends 3%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 1%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C1 lower alcohol solvent of 25kg at every turn, under 80 DEG C of conditions, stir extraction 2 times, each extraction time is 1.5h, extracts material and processes collection clear filtrate after filtration.Be that 0.1 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carry out ultrafiltration with the ultrafilter membrane of molecular cut off 25000Da after obtaining micro-filtrate, the film of receiving of molecular cut off 80Da carries out nanofiltration.The nanofiltration concentrated solution vaporizer obtained is concentrated into 350g, obtains the thick paste of the present composition.
Embodiment 17
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 12%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 1%, french rose spends 1%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 1%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 30%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C1 lower alcohol solvent of 1kg at every turn, under 40 DEG C of conditions, stir extraction 3 times, each extraction time is 0.2h, extracts material and processes collection clear filtrate after filtration.Above-mentioned clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining 0.2 μm, aperture micro-filtration membrane, carrying out ultrafiltration with molecular cut off 6000Da ultrafilter membrane after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving of molecular cut off 150Da.The nanofiltration concentrated solution vaporizer obtained is concentrated into 2000g, obtains present composition extracting solution.
Embodiment 18
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 19%, Nidus collocaliae 24%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 3%, Herba thymi vulgaris 1%, french rose spends 1%, Egyptian blue oral shui solution 1%, Radix Astagali root 6%, dioscorea mexicana root 5%, Flos persicae 1%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, and be then placed in extraction pot, add the purified water of 10kg, stir extraction 1 time under 50 DEG C of conditions, extraction time is 0.25h, extracts material and processes collection clear filtrate after filtration.Being that 0.3 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carrying out ultrafiltration with the ultrafilter membrane that molecular cut off is 5000Da after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving that molecular cut off is 80Da.By the nanofiltration concentrated solution spraying dry obtained, obtain the powder 200g of Chinese medicine composition of the present invention.
Embodiment 19
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 3%, Herba thymi vulgaris 1%, french rose spends 33%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 3%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the purified water of 20kg at every turn, under 20 DEG C of conditions, stir extraction 2 times, each extraction time is 2.5h, extracts material and processes collection clear filtrate after filtration.Be that 1 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carry out ultrafiltration with the ultrafilter membrane of molecular cut off 20000Da after obtaining micro-filtrate, the film of receiving of molecular cut off 300Da carries out nanofiltration.The nanofiltration concentrated solution vaporizer obtained is concentrated into 350g, obtains the thick paste of the present composition.
Embodiment 20
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 33%, Herba thymi vulgaris 3%, french rose spends 3%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 1%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C3 lower alcohol solvent of 10kg at every turn, under 5 DEG C of conditions, stir extraction 3 times, each extraction time is 1.5h, extracts material and processes collection clear filtrate after filtration.Above-mentioned clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining 0.1 μm, aperture micro-filtration membrane, carrying out ultrafiltration with molecular cut off 25000Da ultrafilter membrane after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving of molecular cut off 250Da.The nanofiltration concentrated solution vaporizer obtained is concentrated into 2000g, obtains present composition extracting solution.
Embodiment 21
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 8%, Nidus collocaliae 8%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 10%, french rose spends 1%, Egyptian blue oral shui solution 7%, Radix Astagali root 5%, dioscorea mexicana root 5%, Flos persicae 5%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 15%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, and be then placed in extraction pot, add the purified water of 30kg, stir extraction 1 time under 30 DEG C of conditions, extraction time is 3h, extracts material and processes collection clear filtrate after filtration.Being that 0.5 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carrying out ultrafiltration with the ultrafilter membrane that molecular cut off is 8000Da after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving that molecular cut off is 100Da.By the nanofiltration concentrated solution spraying dry obtained, obtain the powder 200g of Chinese medicine composition of the present invention.
Embodiment 22
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 18%, Flos Rosae Rugosae 5%, Flos Moutan 5%, Herba Saussureae Involueratae 3%, lavandula angustifolia 3%, Herba thymi vulgaris 1%, french rose spends 2%, Egyptian blue oral shui solution 5%, Radix Astagali root 7%, dioscorea mexicana root 5%, Flos persicae 2%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 14%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C2 lower alcohol solvent of 10kg at every turn, under 25 DEG C of conditions, stir extraction 2 times, each extraction time is 0.5h, extracts material and processes collection clear filtrate after filtration.Be that 0.6 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carry out ultrafiltration with the ultrafilter membrane of molecular cut off 6000Da after obtaining micro-filtrate, the film of receiving of molecular cut off 100Da carries out nanofiltration.The nanofiltration concentrated solution vaporizer obtained is concentrated into 350g, obtains present composition thick paste.
Embodiment 23
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 14%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 1%, french rose spends 1%, Egyptian blue oral shui solution 1%, Radix Astagali root 5%, dioscorea mexicana root 31%, Flos persicae 1%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, then be placed in extraction pot, add the C2 lower alcohol solvent of 5kg at every turn, stir extraction 3 times at ambient temperature, each extraction time is 1h, extracts material and processes collection clear filtrate after filtration.Above-mentioned clear filtrate being removed the impurity such as large diameter thalline, suspended solid with retaining 0.3 μm, aperture micro-filtration membrane, carrying out ultrafiltration with molecular cut off 5000Da ultrafilter membrane after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving of molecular cut off 150Da.The nanofiltration concentrated solution vaporizer obtained is concentrated into 2000g, obtains present composition extracting solution.
Embodiment 24
The Chinese medicine composition with multiple beauty functions is made up of following proportioning component: gross weight is 1000g, and the consumption percetage by weight of each component is: Radix Ginseng 5%, Cordyceps militaris (L.) Link. 5%, Nidus collocaliae 5%, Ganoderma 5%, Herba Dendrobii 5%, Flos Rosae Rugosae 5%, Flos Moutan 2%, Herba Saussureae Involueratae 2%, lavandula angustifolia 2%, Herba thymi vulgaris 1%, french rose spends 1%, Egyptian blue oral shui solution 1%, Radix Astagali root 26%, dioscorea mexicana root 5%, Flos persicae 15%, Rhizoma Polygonati Odorati 5%, Rhizoma Chuanxiong 5%, Magnolia sieboldii 5%.
Preparation method is as follows: mix homogeneously after above each Chinese crude drug component being pulverized, and be then placed in extraction pot, add the purified water of 40kg, stir extraction 1 time under 40 DEG C of conditions, extraction time is 2.5h, extracts material and processes collection clear filtrate after filtration.Being that 0.2 μm of micro-filtration membrane removes the impurity such as large diameter thalline, suspended solid by above-mentioned clear filtrate with retaining aperture, carrying out ultrafiltration with the ultrafilter membrane that molecular cut off is 20000Da after obtaining micro-filtrate, then carrying out nanofiltration with the film of receiving that molecular cut off is 200Da.By the nanofiltration concentrated solution spraying dry obtained, obtain the powder 200g of Chinese medicine composition of the present invention.
Embodiment 25
There is a cosmetic water for multiple beauty functions, have following mass percent component to make,
Preparation method is as follows:
1. stir while EDTA-Na2, glycerol, butanediol and pure water are dropped in agitated kettle one by one, be then heated to system temperature about 85 ~ 90 DEG C; 2. then standing insulation is cooled to about 60 DEG C, by amino acid humectant input system while stirring slowly with sterilizing in 20 minutes; 3. continue stirring when being cooled to about 40 DEG C, by with there is the Chinese medicine composition of multiple beauty functions and Methylisothiazolinone respectively in input system, and continue stir about 10 minutes, stop stirring, cooling, then censorship treat discharging.Preferably, described in there is multiple beauty functions the Chinese medicine composition Chinese medicine composition with multiple beauty functions of selecting embodiment 5 obtained, the Chinese medicine composition of what other embodiments obtained have multiple beauty functions has same effect.
Embodiment 26
Have a facial film for multiple beauty functions, it is made up of following percentage by weight raw material:
Appropriate amount of essence and other active component can also be added in addition.The Chinese medicine composition with multiple beauty functions that the Chinese medicine composition preferred embodiment 6 wherein with multiple beauty functions obtains.
The above-mentioned step with the preparation method of the facial film of multiple beauty functions is as follows:
(1) join in polyvinyl acetate emulsion by polyvinyl alcohol, stirring is mixed stand-by;
(2) sodium carboxymethyl cellulose, the Chinese medicine composition with multiple beauty functions and propyl p-hydroxybenzoate are joined mix and blend in part (total amount 30-60%) distilled water, and be heated to about 80 DEG C, stir 2 hours, cool stand-by;
(3) by tween, glycerol and residue distilled water and essence mixing, stir stand-by;
(4) solution (2) is poured in solution (1), again solution (3) is poured into after stirring, be uniformly mixed 3 hours and get product.
According to the regulation of " cosmetics management and safety and Efficiency assessment ", respectively Skin Irritation Test, Ocular irritation experiment and the detection of bacterial micro-organism aspect are carried out to the product of embodiment 1-embodiment 26, as the research of testing the security test of above product, the requirement of indices result display symbol combination cosmetic.
Effect of Chinese medicine composition of the present invention is verified below in conjunction with Cell. Mol and clinical observation.
Melanic inhibition test in Melanoma B16 cell
Experimental technique is as follows:
(1) B16 cell recovered and cultivate, detecting and the previous day cell is gone down to posterity, make its degree of converging be 30%-50%, during detection, using the high sugared complete medium of DMEM-.
(2) second days agent-feeding treatment, see that culture medium has obvious color to change, and when having black precipitate in microscopic examination to cell, collecting cell.
(3) 1 × 10 is gathered in the crops
6cell, PBS washes twice, adds 200uL redistilled water and precipitation is suspended, add the ethanol of 1mL: ether (1:1) mixed liquor, the centrifugal 5min of left at room temperature 20min, 3000r/min.
(4) precipitation adds 1mol/L NaOH l ml (containing 10%DMSO), on the spectrophotometer of 415nm surveys absorbance after hatching 30min in 80 DEG C of water-baths.
B16 cell suppression ratio (%)=(1-drug treating class value/blank class value) × 100.
Experimental result:
Result shows: the product that embodiment 5,6,7,25,26 obtains all has significant B16 cell inhibitory action, and Skin Cell is that just synthesis of melanin absorption is ultraviolet in order to avoid self-inflicted injury, cell in above-mentioned experiment can synthesize by check melanin after the product adding embodiment 5,6,7,25,26, namely illustrates that these products can absorb ultraviolet.Just because product absorbs ultraviolet, the present invention also can realize reducing pigmentation, the beauty functions of desalination mottle.In addition, experiment shows, other embodiments also have identical effect.
The clearance rate efficacy test of hydroxy radical
Experimental technique:
Get 7 10ml color comparison tubes, add the Tris-HCl buffer solution (pH7.47) of 0.3ml l ferrous ammonium sulfate solution (7.5mmol/L), 0.3ml orthophenanthroline solution (7.5mmol/L), 1ml respectively successively, in 2,3,4,5,6, No. 7 color comparison tubes, respectively add the H of 0.2ml
2o
2(7.5mmol/L), then in 3,4,5,6, No. 7 color comparison tubes, add the medicinal liquid of 0.3ml Vc solution (1mg/ml) and above-described embodiment respectively, scale is settled to redistilled water, in the water-bath of 37 DEG C, reaction 1h, in the interscan of 450 ~ 550nm wave-length coverage, obtain maximum absorption wavelength, and densitometric value at this wavelength.
The clearance rate of hydroxy radical is calculated: clearance rate (%)=(OD according to following formula
sample-OD
damage)/(OD
do not damage-OD
damage) × 100.In formula, OD
sample, OD
do not damageand OD
damage, be respectively add Vc solution or embodiment medicinal liquid hydroxy radical system, do not add H
2o
2and add H
2o
2optical density value.(experimental result refers to Fig. 1)
Result shows: the product that embodiment 5,25,26 obtains all has the elimination effect of good hydroxy radical, and the destruction of the collagen protein reduced in radical pair Skin Cell membrane tissue and active substance, the normal water conservation degree of skin and elasticity can be maintained, reach the beauty functions of the skin that compacts, desalination wrinkle, the aging of delaying skin tissue.Shown by other experiments, other embodiments also have identical effect.
The moistening effect of skin is tested
Experimental technique:
(1) before test, experimenter needs unification clean water both hands inner forearm, carries out measurement markers after cleaning at experimenter's both hands inner forearm.
(2) by each group of test specimen and recipient site random number, the contrast order of test specimen and recipient site is determined.Pilot region interval 1cm, often locating pilot region is 5cm × 5cm.
(3) with latex finger cot, sample is spread evenly across in trial zone, waits for 15min.
(4) measure the change of day part MMV value with moisture of skin tester respectively, the meansigma methods at every turn detected is deducted the changing value that blank value is this period MMV value, then remove the rate of increase that namely blank value draws MMV value.
(5) commercially available Aloe powder, hyaluronic acid, ceramide, Sargassum polysaccharides are mixed with aqueous solution respectively, simultaneously with the mask product of the compositions extracting solution of embodiment 5, the cosmetic water of embodiment 25 and embodiment 26, test the change of skin MMV value in 4 hours.(experimental result refers to Fig. 2)
Result shows: the product that embodiment 5,25,26 obtains has significant lasting moistening effect to skin.And moisturizing can prevent skin from becoming dry; skin is made to keep normal wetting state; improve skin histology metabolism; promote release and the Transdermal absorption of active matter; guarantee that active component arrives focus fast, repair impaired skin, promote the blood circulation of skin; and then strengthen skin to the absorption of nutrition, allow skin present ruddy soft.
Shown by other experiments, other embodiments also have identical effect.
The EDU cell proliferation of compositions extracting solution detects
Experimental technique:
(1) cell culture:
To take the logarithm trophophase cell, with every hole 4 × 10
3~ 1 × 10
5cell is inoculated in 96 orifice plates, is cultured to normal growth stage.
(2) EdU labelling:
Every hole adds 100 μ L, 50 μMs of EdU culture medium and hatches 2 hours, abandons culture medium.PBS cleans cell 1 ~ 2 time, each 5 minutes.
(3) Apollo dyeing:
Every hole adds appropriate Apollo staining reaction liquid, after lucifuge, room temperature, decolorization swinging table hatch 30 minutes, abandons staining reaction liquid; Add penetrating agent decolorization swinging table cleaning 2 ~ 3 times, abandon penetrating agent; Every hole is respectively with washed with methanol, PBS cleaning.
(4) DNA dyeing:
Every hole adds appropriate Hoechst reactant liquor, after lucifuge, room temperature, decolorization swinging table hatch 30 minutes, abandons staining reaction liquid; Every hole adds 100 μ L PBS at every turn and cleans 1 ~ 3 time.(experimental result refers to Fig. 3)
Result shows: the compositions extracting solution using embodiment 5, can accelerate the increment division of cell and promote that cell increases, can reach the effect of repairing impaired skin and healing a wound.Shown by other experiments, other embodiments also have identical effect.
Above-described embodiment is the present invention's preferably embodiment; but embodiments of the present invention are not restricted to the described embodiments; change, the modification done under other any does not deviate from spirit of the present invention and principle, substitute, combine, simplify; all should be equivalent replacement mode, be included within protection scope of the present invention.
Claims (7)
1. there is the Chinese medicine composition of multiple beauty functions, it is characterized in that: be made up of the component comprising following parts by weight: Radix Ginseng 5 ~ 40, Cordyceps militaris (L.) Link. 5 ~ 40, Nidus collocaliae 5 ~ 40, Ganoderma 5 ~ 40, Herba Dendrobii 5 ~ 40, Flos Rosae Rugosae 5 ~ 40, Flos Moutan 2 ~ 35, Herba Saussureae Involueratae 2 ~ 35, lavandula angustifolia 2 ~ 35, Herba thymi vulgaris 1 ~ 35, french rose spend 1 ~ 35, Egyptian blue oral shui solution 1 ~ 35, Radix Astagali root 5 ~ 40, dioscorea mexicana root 5 ~ 40, Flos persicae 1 ~ 35, Rhizoma Polygonati Odorati 5 ~ 40, Rhizoma Chuanxiong 5 ~ 40, Magnolia sieboldii 5 ~ 40.
2. a kind of Chinese medicine composition preparation method with multiple beauty functions according to claim 1, is characterized in that: it step comprised is as follows:
(1) pretreatment of raw material: respectively Radix Ginseng, Cordyceps militaris (L.) Link., Nidus collocaliae, Ganoderma, Herba Dendrobii, Flos Rosae Rugosae, Flos Moutan, Herba Saussureae Involueratae, lavandula angustifolia, Herba thymi vulgaris, french rose flower, Egyptian blue oral shui solution, Radix Astagali root, dioscorea mexicana root, Flos persicae, Rhizoma Polygonati Odorati, Rhizoma Chuanxiong, Magnolia sieboldii are ground into 10 ~ 100 object powder, then mix homogeneously;
(2) extract and filter: the component through pulverizing is placed in extraction pot, add water or C1 ~ C3 lower alcohol solvent of component weight 1 ~ 50 times, extract 1 ~ 3 time under 5 ~ 100 DEG C of conditions, each extraction time is 10 ~ 180min, then collecting by filtration clear filtrate;
(3) microfiltration: by clear filtrate with retaining 0.1 ~ 1 μm, aperture micro-filtrate membrane filtration, obtain micro-filtrate;
(4) ultrafiltration: the ultrafilter membrane of micro-filtrate molecular cut off 5000 ~ 30000Da is carried out ultrafiltration and obtains ultrafiltrate;
(5) nanofiltration: the film of receiving of ultrafiltrate molecular cut off 80 ~ 300Da is carried out nanofiltration and obtains nanofiltration liquid.
3. a kind of Chinese medicine composition preparation method with multiple beauty functions according to claim 2, is characterized in that: the Extracting temperature of step (2) is 20 ~ 40 DEG C, and extraction time is 30 ~ 60min.
4. a kind of Chinese medicine composition preparation method with multiple beauty functions according to claim 2, is characterized in that: the aperture of the micro-filtration membrane of step (3) is 0.2 ~ 0.6 μm.
5. a kind of Chinese medicine composition preparation method with multiple beauty functions according to claim 2, is characterized in that: the molecular cut off of the ultrafilter membrane of step (4) is 8000 ~ 20000Da.
6. a kind of Chinese medicine composition preparation method with multiple beauty functions according to claim 2, is characterized in that: the molecular cut off of the NF membrane of step (5) is 100 ~ 200Da.
7. a kind of Chinese medicine composition with multiple beauty functions according to claim 2, is characterized in that: in cosmetics, and its addition is 0.5 ~ 20%.
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| CN106551888A (en) * | 2016-11-17 | 2017-04-05 | 长沙玉容本草保健食品有限责任公司 | Anti-ageing anti-wrinkle face cream of a kind of beautiful face and preparation method thereof |
| CN107303262A (en) * | 2016-04-22 | 2017-10-31 | 长沙俏颜堂生物科技有限公司 | A kind of formula and processing technology of beautifying face and moistering lotion anti-aging skin care product |
| CN107495388A (en) * | 2017-10-20 | 2017-12-22 | 广西佛斯肽生物科技有限公司 | A kind of preparation method of bird's nest polypeptide powder |
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| CN108066241A (en) * | 2018-01-09 | 2018-05-25 | 北京明弘科贸有限责任公司 | It is a kind of that there is moisturizing and the Chinese medicine composition repaired and preparation method thereof |
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| CN1522581A (en) * | 2003-02-18 | 2004-08-25 | 戚海燕 | Edible and skin-care milk powder |
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| CN108057051A (en) * | 2016-11-08 | 2018-05-22 | 海运贸易有限公司 | Composition comprising Herba Saussureae Involueratae and birds nest extract and its preparation method and application |
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| KR101993376B1 (en) * | 2017-11-10 | 2019-06-26 | 주식회사 코리아나화장품 | Cosmetic composition having shining pearl surface containing magnolia sieboldii extract |
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| CN108578295A (en) * | 2018-06-26 | 2018-09-28 | 湖南御家化妆品制造有限公司 | A kind of composition and its application in preparing the cosmetics with bright face function |
| CN109464630A (en) * | 2018-11-13 | 2019-03-15 | 广州知旺科技有限公司 | A kind of composition of liver-protecting fat-dropping and preparation method thereof |
| CN109646356A (en) * | 2019-01-30 | 2019-04-19 | 邯郸市丛台区本草汉方贸易有限公司 | Chinese medicine composition, its purposes and facial mask |
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| CN117414311A (en) * | 2023-11-15 | 2024-01-19 | 广州市华侬化妆品股份有限公司 | Anti-aging composition containing collagen and application thereof |
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Application publication date: 20150722 |