CN117414311B - Anti-aging composition containing collagen and application thereof - Google Patents
Anti-aging composition containing collagen and application thereof Download PDFInfo
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- CN117414311B CN117414311B CN202311519637.7A CN202311519637A CN117414311B CN 117414311 B CN117414311 B CN 117414311B CN 202311519637 A CN202311519637 A CN 202311519637A CN 117414311 B CN117414311 B CN 117414311B
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 131
- 108010035532 Collagen Proteins 0.000 title claims abstract description 131
- 229920001436 collagen Polymers 0.000 title claims abstract description 131
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 71
- 239000000203 mixture Substances 0.000 title claims abstract description 59
- 239000000284 extract Substances 0.000 claims abstract description 156
- 240000009085 Nymphaea caerulea Species 0.000 claims abstract description 39
- 235000002195 Nymphaea caerulea Nutrition 0.000 claims abstract description 39
- 229940107131 ginseng root Drugs 0.000 claims abstract description 39
- 229940064064 purslane extract Drugs 0.000 claims abstract description 39
- 241001673954 Magnolia sieboldii Species 0.000 claims abstract description 38
- 239000002904 solvent Substances 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 47
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 37
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 37
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 37
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 37
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 37
- 150000001875 compounds Chemical class 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 description 40
- 230000000694 effects Effects 0.000 description 29
- 238000003756 stirring Methods 0.000 description 22
- 230000037303 wrinkles Effects 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 18
- 239000000047 product Substances 0.000 description 14
- 102000001187 Collagen Type III Human genes 0.000 description 11
- 108010069502 Collagen Type III Proteins 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- 238000001816 cooling Methods 0.000 description 10
- 239000003205 fragrance Substances 0.000 description 10
- 238000010438 heat treatment Methods 0.000 description 10
- 238000005303 weighing Methods 0.000 description 10
- 241000196324 Embryophyta Species 0.000 description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 8
- 229910052708 sodium Inorganic materials 0.000 description 8
- 239000011734 sodium Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- 241000205585 Aquilegia canadensis Species 0.000 description 6
- 229940059958 centella asiatica extract Drugs 0.000 description 6
- 210000002950 fibroblast Anatomy 0.000 description 6
- 229940087603 grape seed extract Drugs 0.000 description 6
- 235000002532 grape seed extract Nutrition 0.000 description 6
- 235000020748 rosemary extract Nutrition 0.000 description 6
- 229940092258 rosemary extract Drugs 0.000 description 6
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 6
- 239000001717 vitis vinifera seed extract Substances 0.000 description 6
- 238000005259 measurement Methods 0.000 description 5
- 230000032683 aging Effects 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 230000009469 supplementation Effects 0.000 description 3
- 230000001502 supplementing effect Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- -1 skin conditioner Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960005188 collagen Drugs 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 210000001626 skin fibroblast Anatomy 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biotechnology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of skin care products, and particularly discloses an anti-aging composition containing collagen and application thereof. The anti-aging composition containing collagen comprises the following components in parts by weight: 0.05-0.15 parts of collagen; 0.8-1.2 parts of Egyptian blue water lily flower extract; 1.8-2.2 parts of magnolia sieboldii extract; 1.8-2.2 parts of purslane extract; 0.3-0.7 part of ginseng root extract; 0.5-0.7 parts of skin conditioner; 18-22 parts of solvent. The invention has the advantage of improving the anti-aging effect.
Description
Technical Field
The invention relates to the field of skin care products, in particular to an anti-aging composition containing collagen and application thereof.
Background
The skin care product has the effects of beautifying, enhancing the self-confidence of people, improving the image of people, improving the national consumption capacity along with economic development, and being no longer a luxury product which is only used by people with rich content, and being one of necessary consumer products for most people when the skin care product is moved into common families.
The skin care product has various effects, and can achieve more remarkable skin care effects by using skin care products with corresponding effects aiming at different skin problems, wherein the anti-aging effect is especially favored by people, the human body aging is a necessary process along with the aging, the image can be greatly improved by delaying the skin aging speed through the skin care product, the skin aging is most directly represented as skin wrinkles, the wrinkles are generated mainly because of the loss of collagen in the skin, the skin skeleton is lost, the skin is difficult to support, the skin is recessed in a line shape, the skin wrinkles become more obvious along with the loss of collagen, collagen components are usually added into the skin care product for increasing the collagen in the skin through skin absorption, but the practical surface is very low in the collagen absorption capacity, and the anti-aging and anti-wrinkle effects are more general through the addition of the collagen components, so that the improvement is still provided.
Disclosure of Invention
In order to improve the anti-aging effect, the application provides an anti-aging composition containing collagen and application thereof.
In a first aspect, the present application provides an anti-aging composition containing collagen, which adopts the following technical scheme:
an anti-aging composition containing collagen comprises the following components in parts by weight:
0.05-0.15 parts of collagen;
0.8-1.2 parts of Egyptian blue water lily flower extract;
1.8-2.2 parts of magnolia sieboldii extract;
1.8-2.2 parts of purslane extract;
0.3-0.7 part of ginseng root extract;
0.5-0.7 parts of skin conditioner;
18-22 parts of solvent.
By adopting the technical scheme, the active components in the components are synergistic with each other through the cooperation of the Egypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract, so that fibroblasts in the skin can be stimulated, the activity of the fibroblasts is recovered, the collagen synthesis speed of the skin is improved, and the collagen is matched to supplement the skin collagen, so that the collagen is quickly supplemented through the combination of internal synthesis and external supplementation, the collagen loss speed caused by the metabolism is resisted, the collagen generation speed through synthesis and absorption is higher than the collagen loss speed through metabolism, the total amount of the collagen in the skin is in an accumulated and increased state, the collagen supplement in the real sense is realized, the skin skeleton is reconstructed through the collagen, the skin tissue is supported, the effect of removing wrinkles is realized, the better anti-aging effect is realized, and the skin care effect of the anti-aging composition is better.
Preferably, the skin conditioning agent is a combination of sodium hyaluronate and 1, 2-hexanediol.
By adopting the technical scheme, the effects of moisturizing and moisturizing can be achieved by specifically selecting the sodium hyaluronate and the 1, 2-hexanediol, and the skin is healthier and better in skin care effect by supplementing moisture to the skin.
Preferably, the mass ratio of the sodium hyaluronate to the 1, 2-hexanediol is 0.05-0.15:0.45-0.55.
By adopting the technical scheme, the water supplementing and moisturizing effects are better and the skin care effects of the anti-aging composition are better improved by specifically selecting the mass ratio of the sodium hyaluronate to the 1, 2-hexanediol.
Preferably, the solvent is water.
By adopting the technical scheme, the water is specifically selected, so that the dissolution effect of each component is better, each component in the prepared anti-aging composition is uniformly dispersed, the effect can be better exerted, and the skin care effect is improved.
Preferably, the collagen is recombinant type III collagen powder.
By adopting the technical scheme, the effect of absorbing the collagen by the skin is better by specifically selecting the recombinant III type collagen powder, the collagen can be better supplemented, and the anti-aging effect is better.
Preferably, the mass ratio of the Egypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract is 0.9-1.1:1.9-2.1:1.9-2.1:0.4-0.6.
By adopting the technical scheme, the mass ratio of the Egypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract is specifically selected, so that the mutual matching effect of the components is better, the activity of fibroblasts is better activated, the collagen synthesis capability of the skin is better recovered, the collagen is better supplemented by the skin, and the anti-aging effect takes effect faster.
Preferably, the Egypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract are all water-soluble extracts.
By adopting the technical scheme, the water-soluble extract is specifically selected, so that active ingredients in the Egypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract are easier to be absorbed by skin along with the skin care product, and the effect of activating the activity of the skin fibroblast is better.
In a second aspect, the present application provides an application of an anti-aging composition containing collagen, which adopts the following technical scheme:
the application of the collagen-containing anti-aging composition is that the collagen-containing anti-aging composition is added into skin care products to prepare the skin care products with anti-aging effect.
By adopting the technical scheme, the prepared skin care product has good anti-aging effect, quick response and good skin care effect.
Preferably, the collagen-containing anti-aging composition is added to the skin care product in an amount of 25-30%.
By adopting the technical scheme, the anti-aging effect can be kept very good, the cost can be controlled, and the economic value is higher.
In summary, the present application has the following beneficial effects:
1. according to the skin care composition, the Egypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract are matched, so that the active components in the components can stimulate fibroblasts in the skin under the mutual synergistic effect, the activity of the fibroblasts is recovered, the speed of synthesizing collagen by the skin is improved, the collagen is supplemented by matching with collagen, the collagen is quickly supplemented by combining internal synthesis with external supplementation, the collagen loss speed caused by metabolism is resisted, the collagen loss speed caused by synthesis and absorption is higher than the collagen loss speed caused by metabolism, the total amount of collagen in the skin is in an accumulated and increased state, the real collagen supplementation is realized, the skin skeleton is reconstructed by the collagen, the effects of fading and even removing wrinkles are realized, the better anti-aging effect is realized, and the skin care effect of the anti-aging composition is better.
2. In the application, the sodium hyaluronate and the 1, 2-hexanediol are preferably selected specifically, so that the effects of moisturizing can be achieved, and the skin is healthier and better in skin care effect through supplementing moisture to the skin.
3. In the application, the mass ratio of the Egypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract is preferably selected, so that the mutual matching effect of the components is better, the activity of fibroblasts is better activated, the collagen synthesis capability of the skin is better recovered, the collagen is better supplemented by the skin, and the anti-aging effect is faster.
Detailed Description
The present application is described in further detail below with reference to examples.
Example 1
An anti-aging composition containing collagen is prepared from the following components:
collagen, egyptian blue water lily flower extract, magnolia sieboldii extract, purslane extract, ginseng root extract, skin conditioner and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, the Egypt blue water lily flower extract is purchased from the Guangzhou Fuzhilin biotechnology company, and the extraction ratio of the water-soluble extract is 10:1.
wherein, the magnolia sieboldii extract is purchased from HYUNDAI bio line co., ltd., water soluble extract, the extraction ratio is 10:1.
wherein, purslane extract is purchased in HYUNDAI BIOLAND CO., LTD., water-soluble extract, extraction ratio is 10:1.
wherein, the ginseng root extract is purchased from Shanghai plant sodium biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 18kg of water, then adding 0.8kg of Egyptian blue water lily flower extract, 1.8kg of magnolia sieboldii extract, 1.8kg of purslane extract and 0.3kg of ginseng root extract into the water, heating to 50 ℃, rotating at 120r/min, and stirring for 30min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.05kg of collagen, 0.05kg of sodium hyaluronate and 0.45kg of 1, 2-hexanediol, stirring for 5min at the rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Example 2
An anti-aging composition containing collagen is prepared from the following components:
collagen, egyptian blue water lily flower extract, magnolia sieboldii extract, purslane extract, ginseng root extract, skin conditioner and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, the Egypt blue water lily flower extract is purchased from the Guangzhou Fuzhilin biotechnology company, and the extraction ratio of the water-soluble extract is 10:1.
wherein, the magnolia sieboldii extract is purchased from HYUNDAI bio line co., ltd., water soluble extract, the extraction ratio is 10:1.
wherein, purslane extract is purchased in HYUNDAI BIOLAND CO., LTD., water-soluble extract, extraction ratio is 10:1.
wherein, the ginseng root extract is purchased from Shanghai plant sodium biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 19kg of water, then adding 0.9kg of Egyptian blue water lily flower extract, 1.9kg of magnolia sieboldii extract, 1.9kg of purslane extract and 0.4kg of ginseng root extract into the water, heating to 50-60 ℃, rotating at 120r/min, and stirring for 30-40min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.05kg of collagen, 0.05kg of sodium hyaluronate and 0.45kg of 1, 2-hexanediol, stirring for 5min at the rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Example 3
An anti-aging composition containing collagen is prepared from the following components:
collagen, egyptian blue water lily flower extract, magnolia sieboldii extract, purslane extract, ginseng root extract, skin conditioner and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, the Egypt blue water lily flower extract is purchased from the Guangzhou Fuzhilin biotechnology company, and the extraction ratio of the water-soluble extract is 10:1.
wherein, the magnolia sieboldii extract is purchased from HYUNDAI bio line co., ltd., water soluble extract, the extraction ratio is 10:1.
wherein, purslane extract is purchased in HYUNDAI BIOLAND CO., LTD., water-soluble extract, extraction ratio is 10:1.
wherein, the ginseng root extract is purchased from Shanghai plant sodium biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 20kg of water, then adding 1kg of Egypt blue water lily flower extract, 1kg of magnolia sieboldii extract, 1kg of purslane extract and 0.5kg of ginseng root extract into the water, heating to 50-60 ℃, rotating at 120r/min, and stirring for 30-40min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.1kg of collagen, 0.1kg of sodium hyaluronate and 0.5kg of 1, 2-hexanediol, stirring for 5min at a rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Example 4
An anti-aging composition containing collagen is prepared from the following components:
collagen, egyptian blue water lily flower extract, magnolia sieboldii extract, purslane extract, ginseng root extract, skin conditioner and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, the Egypt blue water lily flower extract is purchased from the Guangzhou Fuzhilin biotechnology company, and the extraction ratio of the water-soluble extract is 10:1.
wherein, the magnolia sieboldii extract is purchased from HYUNDAI bio line co., ltd., water soluble extract, the extraction ratio is 10:1.
wherein, purslane extract is purchased in HYUNDAI BIOLAND CO., LTD., water-soluble extract, extraction ratio is 10:1.
wherein, the ginseng root extract is purchased from Shanghai plant sodium biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 21kg of water, then adding 2.1kg of Egyptian blue water lily flower extract, 2.1kg of magnolia sieboldii extract, 2.1kg of purslane extract and 0.6kg of ginseng root extract into the water, heating to 50-60 ℃, rotating at 120r/min, and stirring for 30-40min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.15kg of collagen, 0.15kg of sodium hyaluronate and 0.55kg of 1, 2-hexanediol, stirring for 5min at a rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Example 5
An anti-aging composition containing collagen is prepared from the following components:
collagen, egyptian blue water lily flower extract, magnolia sieboldii extract, purslane extract, ginseng root extract, skin conditioner and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, the Egypt blue water lily flower extract is purchased from the Guangzhou Fuzhilin biotechnology company, and the extraction ratio of the water-soluble extract is 10:1.
wherein, the magnolia sieboldii extract is purchased from HYUNDAI bio line co., ltd., water soluble extract, the extraction ratio is 10:1.
wherein, purslane extract is purchased in HYUNDAI BIOLAND CO., LTD., water-soluble extract, extraction ratio is 10:1.
wherein, the ginseng root extract is purchased from Shanghai plant sodium biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 22kg of water, then adding 1.2kg of Egyptian blue water lily flower extract, 2.2kg of magnolia sieboldii extract, 2.2kg of purslane extract and 0.7kg of ginseng root extract into the water, heating to 50-60 ℃, stirring for 30-40min at the rotating speed of 120r/min, and obtaining a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.15kg of collagen, 0.15kg of sodium hyaluronate and 0.55kg of 1, 2-hexanediol, stirring for 5min at a rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Comparative example 1
An anti-aging composition containing collagen is prepared from the following components:
collagen, centella asiatica extract, magnolia sieboldii extract, purslane extract, ginseng root extract, skin conditioner, and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, centella asiatica extract is purchased from Woltesi biotechnology limited company, lanzhou, water-soluble extract, the extraction ratio is 10:1.
wherein, the magnolia sieboldii extract is purchased from HYUNDAI bio line co., ltd., water soluble extract, the extraction ratio is 10:1.
wherein, purslane extract is purchased in HYUNDAI BIOLAND CO., LTD., water-soluble extract, extraction ratio is 10:1.
wherein, the ginseng root extract is purchased from Shanghai plant sodium biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 20kg of water, then adding 1kg of centella asiatica extract, 1kg of magnolia sieboldii extract, 1kg of purslane extract and 0.5kg of ginseng root extract into the water, heating to 50-60 ℃, and stirring for 30-40min at the rotating speed of 120r/min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.1kg of collagen, 0.1kg of sodium hyaluronate and 0.5kg of 1, 2-hexanediol, stirring for 5min at a rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Comparative example 2
An anti-aging composition containing collagen is prepared from the following components:
collagen, egyptian blue water lily flower extract, rosemary extract, purslane extract, ginseng root extract, skin conditioner and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, the Egypt blue water lily flower extract is purchased from the Guangzhou Fuzhilin biotechnology company, and the extraction ratio of the water-soluble extract is 10:1.
wherein, the rosemary extract is purchased from the Siemens Biotechnology Co., ltd, and the water-soluble extract has an extraction ratio of 10:1.
wherein, purslane extract is purchased in HYUNDAI BIOLAND CO., LTD., water-soluble extract, extraction ratio is 10:1.
wherein, the ginseng root extract is purchased from Shanghai plant sodium biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 20kg of water, then adding 1kg of Egyptian blue water lily flower extract, 1kg of rosemary extract, 1kg of purslane extract and 0.5kg of ginseng root extract into the water, heating to 50-60 ℃, and stirring for 30-40min at the rotating speed of 120r/min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.1kg of collagen, 0.1kg of sodium hyaluronate and 0.5kg of 1, 2-hexanediol, stirring for 5min at a rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Comparative example 3
An anti-aging composition containing collagen is prepared from the following components:
collagen, egypt blue water lily flower extract, magnolia sieboldii extract, honeysuckle flower extract, ginseng root extract, skin conditioner and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, the Egypt blue water lily flower extract is purchased from the Guangzhou Fuzhilin biotechnology company, and the extraction ratio of the water-soluble extract is 10:1.
wherein, the magnolia sieboldii extract is purchased from HYUNDAI bio line co., ltd., water soluble extract, the extraction ratio is 10:1.
wherein the honeysuckle extract is purchased from Shanyang allied peak biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein, the ginseng root extract is purchased from Shanghai plant sodium biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 20kg of water, then adding 1kg of Egypt blue water lily flower extract, 1kg of magnolia sieboldii extract, 1kg of honeysuckle extract and 0.5kg of ginseng root extract into the water, heating to 50-60 ℃, rotating at 120r/min, and stirring for 30-40min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.1kg of collagen, 0.1kg of sodium hyaluronate and 0.5kg of 1, 2-hexanediol, stirring for 5min at a rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Comparative example 4
An anti-aging composition containing collagen is prepared from the following components:
collagen, egyptian blue water lily flower extract, magnolia sieboldii extract, purslane extract, grape seed extract, skin conditioner and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, the Egypt blue water lily flower extract is purchased from the Guangzhou Fuzhilin biotechnology company, and the extraction ratio of the water-soluble extract is 10:1.
wherein, the magnolia sieboldii extract is purchased from HYUNDAI bio line co., ltd., water soluble extract, the extraction ratio is 10:1.
wherein, purslane extract is purchased in HYUNDAI BIOLAND CO., LTD., water-soluble extract, extraction ratio is 10:1.
wherein, grape seed extract is purchased from Siamiril bioengineering Co., ltd., water-soluble extract, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 20kg of water, then adding 1kg of Egypt blue water lily flower extract, 1kg of magnolia sieboldii extract, 1kg of purslane extract and 0.5kg of grape seed extract into the water, heating to 50-60 ℃, rotating at 120r/min, and stirring for 30-40min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.1kg of collagen, 0.1kg of sodium hyaluronate and 0.5kg of 1, 2-hexanediol, stirring for 5min at a rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Comparative example 5
An anti-aging composition containing collagen is prepared from the following components:
collagen, centella asiatica extract, rosemary extract, honeysuckle extract, grape seed extract, skin conditioning agent, and solvent.
Wherein the collagen is recombinant type III collagen powder-TTA 1-01 (version number 20220418-03) purchased from Jiangsu Chuangjian medical science and technology Co.
Wherein, centella asiatica extract is purchased from Woltesi biotechnology limited company, lanzhou, water-soluble extract, the extraction ratio is 10:1.
wherein, the rosemary extract is purchased from the Siemens Biotechnology Co., ltd, and the water-soluble extract has an extraction ratio of 10:1.
wherein the honeysuckle extract is purchased from Shanyang allied peak biotechnology Co., ltd, and the extraction ratio is 10:1.
wherein, grape seed extract is purchased from Siamiril bioengineering Co., ltd., water-soluble extract, and the extraction ratio is 10:1.
wherein the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
Sodium hyaluronate was purchased from Yu Huaxi biotechnology, inc.
1, 2-hexanediol was purchased from De Xin Xiang essence fragrance (Nantong) Inc.
Wherein the solvent is water.
The preparation method of the anti-aging composition containing collagen comprises the following steps:
step 1), weighing 20kg of water, then adding 1kg of centella asiatica extract, 1kg of rosemary extract, 1kg of honeysuckle extract and 0.5kg of grape seed extract into the water, heating to 50-60 ℃, and stirring for 30-40min at the rotating speed of 120r/min to obtain a premix.
Step 2), cooling the premix to below 30 ℃, adding 0.1kg of collagen, 0.1kg of sodium hyaluronate and 0.5kg of 1, 2-hexanediol, stirring for 5min at a rotating speed of 120r/min, and obtaining the anti-aging composition containing collagen.
Experiment 1
A number of volunteers, aged between 40-50 years, were female, had no severe disease, had wrinkles on the face, and were divided into groups of 10 volunteers, and after rinsing the face with clear water and drying, the skin wrinkles were measured and recorded as initial wrinkles measurements.
The volunteers group the test samples prepared by using the anti-aging composition containing collagen of each example or each comparative example, each time the test samples are used for 2ml each time in the morning and at the evening, the test samples are smeared on the face uniformly, the test samples completely cover the face, the skin is completely absorbed after being smeared on the test samples, the face is cleaned by clear water and wiped dry before the test samples are used, and then the test samples are smeared on horses.
After using the test specimen 90d, the skin wrinkle state was measured again, recorded as 90d wrinkle measurement value, and the face was washed with clear water and wiped dry before measurement.
When the wrinkle state is measured, a rapid three-dimensional skin imaging system PRIMOS is adopted, five parts of the left and right corners of the eye, the middle part of the forehead and cheeks on two sides are detected, the measured value is taken as the average value of the five parts of detection, each group of detection data is taken as the average value, the two parts of detection data are reserved after decimal points are rounded, and the lower the measured value is, the less the skin wrinkles are.
The preparation method of the sample to be tested comprises the following steps:
and (3) taking 25g of the collagen-containing anti-aging composition and 75g of deionized water, putting the collagen-containing anti-aging composition and the deionized water into a stirring kettle, stirring for 5min at the rotating speed of 120r/min, and uniformly mixing to obtain a sample to be tested.
The specific detection results of experiment 1 are shown in Table 1.
TABLE 1
| Initial wrinkle measurement | 90d wrinkle measurement | |
| Example 1 | 38.48 | 30.86 |
| Example 2 | 37.69 | 30.17 |
| Example 3 | 38.24 | 30.55 |
| Example 4 | 38.65 | 30.87 |
| Example 5 | 37.87 | 30.24 |
| Comparative example 1 | 37.93 | 35.02 |
| Comparative example 2 | 38.16 | 35.32 |
| Comparative example 3 | 38.34 | 35.90 |
| Comparative example 4 | 37.98 | 35.38 |
| Comparative example 5 | 38.43 | 36.76 |
According to the comparison of the data of each example and the comparative examples in table 1, the 90d wrinkle measured value of each example is significantly lower than the 90d wrinkle measured value of each comparative example, and the initial wrinkle measured value of each example is similar to the initial wrinkle measured value of each comparative example, each comparative example is different from each example in that one or all of the gypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract of each example is replaced by other plant extracts with antioxidant effect, so that each comparative example damages the compound system of the gypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract, the plant extracts of each comparative example only can play roles of eliminating free radicals and reducing further oxidative aging of skin, namely, the compound system of each comparative example plays roles of slowing down and delaying the generation of wrinkles, collagen is replenished by collagen as skin, and the reduction speed of wrinkles is slower, and each example can play roles of reducing the aging by collagen by the collagen, and the collagen is further activated by the collagen, the collagen is further activated by the combination of the extracts of the gypt blue water lily flower extract, the ginseng root extract and the purslane extract, the collagen is more effective, the skin is reduced, the skin is more has a better skin aging effect, and the skin is more has a better active effect, and has a better effect and has a better skin effect.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (7)
1. An anti-aging composition comprising collagen, characterized in that: comprises the following components in parts by mass:
0.05-0.15 parts of collagen;
0.8-1.2 parts of Egyptian blue water lily flower extract;
1.8-2.2 parts of magnolia sieboldii extract;
1.8-2.2 parts of purslane extract;
0.3-0.7 part of ginseng root extract;
0.5-0.7 parts of skin conditioner;
18-22 parts of a solvent;
the collagen is recombinant III type collagen powder;
the Egypt blue water lily flower extract, the magnolia sieboldii extract, the purslane extract and the ginseng root extract are all water-soluble extracts.
2. An anti-aging composition comprising collagen according to claim 1, wherein: the skin conditioner is a compound of sodium hyaluronate and 1, 2-hexanediol.
3. An anti-aging composition comprising collagen according to claim 2, wherein: the mass ratio of the sodium hyaluronate to the 1, 2-hexanediol is 0.05-0.15:0.45-0.55.
4. An anti-aging composition comprising collagen according to claim 1, wherein: the solvent is water.
5. An anti-aging composition comprising collagen according to claim 1, wherein: the mass ratio of the Egypt blue water lily flower extract to the magnolia sieboldii extract to the purslane extract to the ginseng root extract is 0.9-1.1:1.9-2.1:1.9-2.1:0.4-0.6.
6. Use of an anti-ageing composition comprising collagen according to any one of claims 1 to 5, characterized in that: the anti-aging composition containing collagen is added into skin care products to prepare skin care products with anti-aging effect.
7. Use of an anti-ageing composition comprising collagen according to claim 6, wherein: the addition amount of the collagen-containing anti-aging composition in skin care products is 25-30%.
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