CN117797061B - An antiaging composition containing boscalin, ecadotine and ergothioneine - Google Patents
An antiaging composition containing boscalin, ecadotine and ergothioneine Download PDFInfo
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- CN117797061B CN117797061B CN202311592164.3A CN202311592164A CN117797061B CN 117797061 B CN117797061 B CN 117797061B CN 202311592164 A CN202311592164 A CN 202311592164A CN 117797061 B CN117797061 B CN 117797061B
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- 239000000203 mixture Substances 0.000 title claims abstract description 103
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 57
- SSISHJJTAXXQAX-ZETCQYMHSA-N L-ergothioneine Chemical compound C[N+](C)(C)[C@H](C([O-])=O)CC1=CNC(=S)N1 SSISHJJTAXXQAX-ZETCQYMHSA-N 0.000 title claims abstract description 53
- 229940093497 ergothioneine Drugs 0.000 title claims abstract description 53
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 103
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 103
- 239000005740 Boscalid Substances 0.000 claims abstract description 50
- 229940118790 boscalid Drugs 0.000 claims abstract description 50
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- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims abstract description 33
- 229920002498 Beta-glucan Polymers 0.000 claims abstract description 33
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 244000042430 Rhodiola rosea Species 0.000 claims abstract description 32
- 235000003713 Rhodiola rosea Nutrition 0.000 claims abstract description 32
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229960005323 phenoxyethanol Drugs 0.000 claims abstract description 32
- DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 claims abstract description 22
- -1 ecadoline Chemical compound 0.000 claims abstract description 20
- 244000269722 Thea sinensis Species 0.000 claims abstract 4
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- 229950001184 ecadotril Drugs 0.000 claims 1
- 108700040249 racecadotril Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 230000003020 moisturizing effect Effects 0.000 abstract description 14
- 239000004480 active ingredient Substances 0.000 abstract description 9
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- 238000010521 absorption reaction Methods 0.000 abstract description 5
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- 229960004063 propylene glycol Drugs 0.000 description 31
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- WQXNXVUDBPYKBA-UHFFFAOYSA-N Ectoine Natural products CC1=NCCC(C(O)=O)N1 WQXNXVUDBPYKBA-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
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- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 description 2
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Abstract
The invention relates to the technical field of cosmetics, in particular to an anti-aging composition containing boscalid, ectrodorine and ergothioneine. The composition contains boscalid, ecadoline, ergothioneine, tea extract, rhodiola rosea extract, glyceryl trimyristate, isopropyl palmitate, glycerin, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate, PPG-2-isodecyl polyether-12, phenoxyethanol and water. The anti-aging composition provided by the invention has excellent anti-aging effect, good absorption effect of active ingredients, no irritation and better moisturizing effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging composition containing boscalid, ectrodorine and ergothioneine.
Background
Skin is the largest organ of the human body, and skin aging is an important expression of human body aging. Aging of the skin not only affects the appearance and image of a person, but also seriously hampers the physiological function of the skin. The reduction of the secretion amount of the collagen is a main cause of skin aging, improves the content and activity of the collagen, and has important significance for delaying the skin aging.
The efficacy of the existing anti-aging cosmetics often depends on a single powerful raw material, such as retinol, polyphenol and the like, and the raw materials often have the problems of large irritation, intolerance and the like; there are also many cosmetic products using polypeptides and the like to supplement the collagen content of the skin, but they have the disadvantages of poor skin absorption effect, weak anti-aging effect and the like.
Therefore, the anti-aging composition with strong anti-aging activity, excellent absorption effect and no irritation is developed, and the anti-aging composition has better prospect. However, the existing anti-aging cosmetics do not use the bosin and the ethandine together as anti-aging active ingredients. The invention takes the boscalin and the ethandine as the anti-aging factors for the first time, and adds the ergothioneine to prepare the high-strength anti-aging cosmetic composition.
Disclosure of Invention
The invention provides an anti-aging composition containing boscalid, ethandine and ergothioneine, and the technical scheme of the invention solves the technical problems of insufficient anti-aging activity, poor absorption effect and irritation of the existing cosmetics.
The anti-aging composition provided by the invention has excellent anti-aging effect, good absorption effect of active ingredients, no irritation and better moisturizing effect.
The anti-aging composition has excellent anti-aging effect on the bose factor, the ethandine and the ergothioneine, can increase the plumpness of skin, smooth the skin and inhibit the generation around the skin, and endows the skin with elasticity, and particularly, the anti-aging effect of the composition can be remarkably enhanced by using the combination of the bose factor and the ethandine. The composition contains components such as folium Camelliae sinensis extract, radix Rhodiolae extract, glycerol, beta-glucan, propylene glycol, etc. for moisturizing and antiinflammatory, and has excellent moisturizing and skin soothing effects. Meanwhile, the composition is provided with the polyglycerol-3-dicooleic acid ester and PPG-2-isodecyl polyether-12, so that the anti-aging, moisturizing and anti-inflammatory active ingredients of the composition are efficiently absorbed by the skin and delivered to the deep layer of the skin, and further the functional efficacy of the composition is further enhanced.
In one aspect, the present invention provides an anti-aging composition comprising boscalid, ectoine, ergothioneine, the composition comprising boscalid, ectoine, ergothioneine, tea extract, rhodiola rosea extract, trimyristate, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate, PPG-2-isodecyl polyether-12, phenoxyethanol, and water.
Further, the composition comprises: 0.2-2.5 parts of boscalid, 0.3-2.2 parts of ecadotene, 0.3-2.6 parts of ergothioneine, 0.2-1.5 parts of tea extract, 0.2-1.7 parts of rhodiola rosea extract, 3-10 parts of trimyristate glycerol, 2-7 parts of isopropyl palmitate, 2-6.5 parts of glycerin, 2-7 parts of beta-glucan, 2-6 parts of propylene glycol, 1.2-3.5 parts of polyglycerol-3-cocoate, 1.1-3.2 parts of PPG-2-isodecyl polyether-12, 0.08-0.5 part of phenoxyethanol and 50-80 parts of water; the parts are calculated by mass parts.
Further, the composition comprises: 0.5-2 parts of boscalid, 0.4-2 parts of ecalciferol, 0.5-2.3 parts of ergothioneine, 0.3-1.2 parts of tea extract, 0.4-1.5 parts of rhodiola rosea extract, 4-9 parts of trimyristate, 3-7 parts of isopropyl palmitate, 3-6 parts of glycerol, 2.5-6 parts of beta-glucan, 2.5-5.5 parts of propylene glycol, 1.5-3.2 parts of polyglycerol-3-dicarbamate, 1.2-3 parts of PPG-2-isodecyl polyether-12, 0.1-0.5 part of phenoxyethanol and 55-75 parts of water.
Further, the amount of the bose in the composition is 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.1, 2.2, 2.4 parts by mass or parts by mass ranging between any of the above.
Further, in the composition, the amount of the cocaine is 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.1 parts by mass or parts by mass ranging between any of the above values.
Further, the composition comprises 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.1, 2.2, 2.3, 2.4, 2.5 parts by mass or parts by mass ranging between any of the foregoing.
Further, in the composition, the amount of the tea extract is 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4 parts by mass or parts by mass ranging between any of the above.
Further, the rhodiola rosea extract is used in the composition in an amount of 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6 parts by mass or parts by mass ranging between any of the above values.
Further, the amount of the trimyristate in the composition is 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.2, 7.5, 7.8, 8, 8.2, 8.5, 8.7, 9, 9.2, 9.5, 9.7 parts by mass or parts by mass ranging between any of the above values.
Further, the composition comprises isopropyl palmitate in an amount of 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7 parts by mass or parts by mass ranging between any of the above values.
Further, the amount of glycerin in the composition is 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5 parts by mass or parts by mass in the range between any of the above values.
Further, the composition comprises 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 6.8 parts by mass or parts by mass ranging between any of the foregoing values.
Further, the propylene glycol is used in an amount of 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 5.8 parts by mass or parts by mass ranging between any of the foregoing values in the composition.
Further, the amount of the polyglycerol-3-di-cocoate in the composition is 1.3, 1.5, 1.7, 1.9, 2, 2.2, 2.4, 2.5, 2.8, 3, 3.2, 3.4 parts by mass or parts by mass ranging between any of the above values.
Further, the amount of PPG-2-isodecyl polyether-12 in the composition is 1.3, 1.5, 1.7, 1.9, 2, 2.2, 2.4, 2.5, 2.8, 3 or ranges between any of the above.
Further, the amount of phenoxyethanol in the composition is 0.1, 0.15, 0.2, 0.25, 0.3, 0.34, 0.4, 0.45 parts by mass or parts by mass ranging between any of the above values.
Further, the water is used in an amount of 52, 55, 60, 65, 70, 72, 75, 78, 79 parts by mass or in a range between any of the above values in the composition.
Further, the wave color factor is used in an amount of 0.6 to 1.8 parts.
Further, the content of the ethacryptine is 0.5-1.6 parts.
Further, the usage amount of the ergothioneine is 0.6-2.2 parts.
Further, in order to better enhance the anti-aging effect of the composition on the skin, the mass ratio of the bose factor to the ethacryne in the composition of the present invention is (1.1-1.5): 1. Further alternatively, (1.15-1.5): 1, (1.2-1.5): 1 or (1.2-1.4): 1.
Further, in order to better increase the effect of the active ingredients of the composition, the mass ratio of the polyglycerol-3-dicoleate to the PPG-2-isodecyl polyether-12 in the composition is (0.8-1.3): 1. further options (0.85-1.3): 1. (0.9-1.3): 1. (0.9-1.2): 1 or (0.9-1.1): 1.
In another aspect, the invention provides a method for preparing the anti-aging composition containing boscalid, ecadotene and ergothioneine, which comprises the following steps:
(1) Weighing the raw materials;
(2) Adding water into a reaction kettle, heating, adding glycerol trimyristate, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, and stirring to obtain a mixture;
(3) Cooling the mixture obtained in the step (2), adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring to obtain the composition.
Further, the temperature of the step (2) is increased to 35-85 ℃, and 38 ℃, 40 ℃, 42 ℃, 45 ℃, 47 ℃, 50 ℃, 55 ℃, 60 ℃, 65 ℃, 70 ℃, 75 ℃, 80 ℃, 84 ℃ or a range between any of the above values is further selected.
Further, the temperature of the cooling in the step (2) is 10-34 ℃, and 15 ℃,20 ℃, 25 ℃, 28 ℃, 30 ℃, 33 ℃ or any range between the above values are further selected.
Further, the stirring speeds in the steps (2) and (3) are respectively and independently 10-3000 rpm, and 20 rpm, 50 rpm, 80 rpm, 100 rpm, 200 rpm, 300 rpm, 500 rpm, 800 rpm, 1000 rpm, 1500 rpm, 2000 rpm or a range between any of the above values can be selected.
Further, the stirring time in the steps (2) and (3) is independently 0.1 to 8 hours, and may be selected from 0.2 hours, 0.5 hours, 0.8 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 5 hours, 6 hours, 7 hours, 7.5 hours, or a range between any of the above values.
Further, the invention provides a preparation method of the anti-aging composition containing the boscalid, the ethandine and the ergothioneine, which comprises the following steps:
(1) Weighing the raw materials;
(2) Adding water into a reaction kettle, heating to 35-85 ℃, adding glycerol trimyristate, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, starting stirring, and stirring for 0.1-8 hours at the rotating speed of 10-3000 rpm to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 10-34 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.1-8 hours at the rotating speed of 10-3000 r/min to obtain the composition.
The beneficial effects are that:
1. The anti-aging composition obtained by the steps of boscalid, enodoline, ergothioneine, tea extract, rhodiola rosea extract, glycerol trimyristate, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate, PPG-2-isodecyl polyether-12, phenoxyethanol and water has excellent anti-aging effect, and the active ingredients have good absorption effect, no irritation and good moisturizing effect.
2. The anti-aging composition has excellent anti-aging effect on the bose factor, the ethandine and the ergothioneine, can increase the plumpness of skin, smooth the skin and inhibit the generation around the skin, and endows the skin with elasticity, and particularly, the anti-aging effect of the composition can be remarkably enhanced by using the combination of the bose factor and the ethandine. The composition contains components such as folium Camelliae sinensis extract, radix Rhodiolae extract, glycerol, beta-glucan, propylene glycol, etc. for moisturizing and antiinflammatory, and has excellent moisturizing and skin soothing effects. Meanwhile, the composition is provided with the polyglycerol-3-dicooleic acid ester and PPG-2-isodecyl polyether-12, so that the anti-aging, moisturizing and anti-inflammatory active ingredients of the composition are efficiently absorbed by the skin and delivered to the deep layer of the skin, and further the functional efficacy of the composition is further enhanced.
3. The composition of the invention has excellent heat resistance stability, cold resistance stability and cold and hot circulation stability, and has no abnormality in appearance, color and smell.
4. The composition has excellent anti-aging effect, and the proportion of the volume of the facial fish tail can be reduced to 7.62% in 20 days, and the proportion of the volume of the facial fish tail can be reduced to 18.35% in 20 days; the proportion of the skin elasticity can be increased by 3.81% after 20 days of use, and the proportion of the skin elasticity can be increased by 13.59% after 50 days of use.
5. The both the boscalid and the ethandine can obviously enhance the skin anti-aging effect, and have synergistic effect of promoting the skin to remove wrinkles and increase skin elasticity.
6. The combination of the polyglycerol-3-dicooleic acid ester and the PPG-2-isodecyl polyether-12 in the composition can obviously enhance the anti-aging effect of the composition, and the combination of the polyglycerol-3-dicooleic acid ester and the PPG-2-isodecyl polyether-12 can ensure that active ingredients such as anti-aging and moisturizing of the composition are efficiently absorbed by skin and delivered to deep layers of the skin, so that better effects are exerted, and the anti-aging effect of the composition is enhanced. And when the mass ratio of the two is (0.8-1.3): 1, the composition has better effect of removing wrinkles and increasing skin elasticity.
7. As can be seen from the comparison of test samples 1, 9, 10, the combination of the polyglycerol-3-dicoleate and PPG-2-isodecyl polyether-12 of the invention provides a better anti-aging effect than other components, such as TWEEN-60, APG-0810.
8. The composition has excellent moisturizing effect, the moisture content of the skin can be increased to 41.38% in 3 hours, and the moisture content of the skin can be increased to 30.12% in 8 hours.
Detailed Description
The present invention will be described in conjunction with the following detailed description.
1. Preparation of test samples
Anti-aging compositions containing boscalid, ecadotene, ergothioneine were prepared and designated as test samples.
1. Test sample 1:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 2.3 parts of boscalid, 1.8 parts of ecalciferum, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 2 parts of polyglycerol-3-dicotylenol, 2 parts of PPG-2-isodecyl polyether-12, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the boscalid to the ethandiol is 1.28:1, and the mass ratio of the polyglycerol-3-dicarbamate to the PPG-2-isodecyl polyether-12 is 1:1, a step of;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, starting stirring, and stirring for 1 hour at the rotation speed of 230 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 r/min to obtain the test sample 1.
2. Test sample 2:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 2.2 parts of boscalin, 1.9 parts of ecalciferol, 1.85 parts of ergothioneine, 1 part of tea extract, 1.4 parts of rhodiola rosea extract, 8 parts of trimyristate, 6 parts of isopropyl palmitate, 4.5 parts of glycerin, 5 parts of beta-glucan, 4 parts of propylene glycol, 1.9 parts of polyglycerol-3-dicarbamate, 2.2 parts of PPG-2-isodecyl polyether-12, 0.35 part of phenoxyethanol and 65.17 parts of water; the mass ratio of the boscalid to the ethandiol is 1.16:1, and the mass ratio of the polyglycerol-3-dicoleate to the PPG-2-isodecyl polyether-12 is 0.86:1, a step of;
(2) Adding water into a reaction kettle, heating to 72 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, starting stirring, and stirring for 1.1 hours at the rotating speed of 260 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 22 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.9 hour at the rotating speed of 200 revolutions per minute to obtain the test sample 2.
3. Test sample 3:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 4.1 parts of boscalid, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 2 parts of polyglycerol-3-dicotylenoate, 2 parts of PPG-2-isodecyl polyether-12, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the polyglycerol-3-cocoate to the PPG-2-isodecyl polyether-12 is 1:1, a step of;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, starting stirring, and stirring for 1 hour at the rotation speed of 230 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the boscalid, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 revolutions per minute to obtain the test sample 3.
4. Test sample 4:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 4.1 parts of ecalciferum, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 2 parts of polyglycerol-3-dicocolate, 2 parts of PPG-2-isodecyl polyether-12, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the polyglycerol-3-cocoate to the PPG-2-isodecyl polyether-12 is 1:1, a step of;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, starting stirring, and stirring for 1 hour at the rotation speed of 230 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 revolutions per minute to obtain the test sample 4.
5. Test sample 5:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 2.3 parts of boscalid, 1.8 parts of ecalciferol, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 4 parts of polyglycerol-3-dicotylenol, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the wave color factor to the ecalciferol factor is 1.28:1;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate, isopropyl palmitate, glycerol, beta-glucan, propylene glycol and polyglycerol-3-dicarbamate, starting stirring, and stirring for 1 hour at the rotating speed of 230 rpm to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 revolutions per minute to obtain the test sample 5.
6. Test sample 6:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 2.3 parts of boscalid, 1.8 parts of ecalciferol, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 4 parts of PPG-2-isodecyl polyether-12, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the wave color factor to the ecalciferol factor is 1.28:1;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol and PPG-2-isodecyl polyether-12, starting stirring, and stirring for 1 hour at the rotating speed of 230 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 revolutions per minute to obtain the test sample 6.
7. Test sample 7:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 2.3 parts of boscalid, 1.8 parts of ecalciferum, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 1 part of polyglycerol-3-dicotylenol, 3 parts of PPG-2-isodecyl polyether-12, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the boscalid to the ethandiol is 1.28:1, and the mass ratio of the polyglycerol-3-dicoleate to the PPG-2-isodecyl polyether-12 is 0.33:1, a step of;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, starting stirring, and stirring for 1 hour at the rotation speed of 230 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 revolutions per minute to obtain the test sample 7.
8. Test sample 8:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 2.3 parts of boscalid, 1.8 parts of ecalciferum, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 3 parts of polyglycerol-3-dicotylenol, 1 part of PPG-2-isodecyl polyether-12, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the boscalid to the ethandiol is 1.28:1, and the mass ratio of the polyglycerol-3-dicoleate to the PPG-2-isodecyl polyether-12 is 3:1, a step of;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, starting stirring, and stirring for 1 hour at the rotation speed of 230 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 revolutions per minute to obtain the test sample 8.
9. Test sample 9:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 2.3 parts of boscalid, 1.8 parts of ecadotene, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 4 parts of TWEEN-60, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the wave color factor to the ecalciferol factor is 1.28:1;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol and TWEEN-60, starting stirring, and stirring for 1 hour at the rotating speed of 230 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 revolutions per minute to obtain the test sample 9.
10. Test sample 10:
the preparation method comprises the following steps:
(1) Weighing raw materials according to the mass parts: 2.3 parts of boscalid, 1.8 parts of ecadotene, 1.9 parts of ergothioneine, 1.1 parts of tea extract, 1.3 parts of rhodiola rosea extract, 8.2 parts of trimyristate, 5.8 parts of isopropyl palmitate, 5 parts of glycerol, 4.5 parts of beta-glucan, 4.2 parts of propylene glycol, 4 parts of APG-0810, 0.35 part of phenoxyethanol and 64.55 parts of water; the mass ratio of the wave color factor to the ecalciferol factor is 1.28:1;
(2) Adding water into a reaction kettle, heating to 70 ℃, adding glycerol trimyristate ester, isopropyl palmitate, glycerol, beta-glucan, propylene glycol and APG-0810, starting stirring, and stirring for 1 hour at the rotation speed of 230 r/min to obtain a mixture;
(3) Cooling the mixture obtained in the step (2) to 25 ℃, adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring for 0.8 hour at the rotating speed of 180 revolutions per minute to obtain the test sample 10.
Raw material sources in the preparation process are as follows: the wave color factor is as follows: wuhan Lax pharmaceutical chemical Co., ltd; the following reasons: suzhou navigation biotechnology limited; ergothioneine: wuhank Mike Biomedicine technologies Co., ltd; tea extract: fufeng Scott Biotech Co Ltd; rhodiola rosea extract: mountain yang allies oneself with peak biotechnology limited liability company; glycerol trimyristate ester: guangdong Weng Jiang chemical Co., ltd; isopropyl palmitate: shandong national chemical Co., ltd; glycerol: shandong Qianxiang chemical Co., ltd; beta-glucan: shandong Siyang Biotech Co., ltd; propylene glycol: the above-mentioned use is 1, 2-propanediol, jinan Zesheng chemical Co., ltd; phenoxyethanol; jinan Rong Zheng chemical industry Co., ltd; TWEEN-60: the Taizhou Jiayin chemical Co., ltd; APG-0810: shandong Denno New Material technologies Co.
2. Performance testing
The above samples 1 to 10 were subjected to performance test.
1. Stability test:
Carrying out heat resistance, cold resistance and cold and heat cycle stability test on the test samples 1-10; the heat resistance stability test is to stand for 30 days at 45+/-2 ℃ and observe the change of appearance, color and smell of a sample; the cold resistance stability test is that the sample is stood for 30 days at the temperature of minus 18 plus or minus 2 ℃ and the change of appearance, color and smell of the sample is observed; the cold and hot cycle stability test is to store at 45 deg.C, normal temperature and-18 deg.C for 24 hr, and circulate for 3 times, and observe the change of appearance, color and smell.
The test results showed that the test samples 1 to 8 were excellent in heat stability, cold stability and stability in cold and heat cycles, and were free from abnormalities in appearance, color and smell. The cold-resistant stability and the cold-heat cycle stability of the test samples 9-10 are relatively poor, and the tested samples have trace turbidity and have no obvious abnormality in color and smell.
2. Anti-aging Effect test
The anti-aging effect is characterized by adopting the volume change rate of facial fish tail wrinkles and the elastic effect test of facial skin.
The test object: selecting a plurality of subjects with ages of 30-55 years, no skin diseases, dry skin and no obvious difference of skin water content. The randomization was divided into 10 groups of 10 persons each, 5 for men and women.
Use of test samples: each group of subjects used 1.5g of the sample per face and smeared evenly, before using the test samples described above, and were cleaned with clear water and then wiped dry. It is used once daily at night for 50 days.
Facial fish tail wrinkle volume change rate test: each group of subjects was cleaned and wiped dry with clear water prior to testing, and then facial skin images of the subjects were collected and data analysis of facial skin fish tail wrinkle volumes was performed. Facial skin images of each group of subjects were collected and analyzed for facial skin fish tail wrinkle volume data using 20 days, 50 days, prior to use of the test sample. The rate of change of facial fish tail wrinkle volume was then calculated for the subjects, and then the average was taken as the average rate of change of facial fish tail wrinkle volume for each group. For example, a subject has a facial fishtail wrinkle volume change rate of 20 days=100% (facial fishtail wrinkle volume of 20 days-facial fishtail wrinkle volume before use)/facial fishtail wrinkle volume before use, and a subject has a facial fishtail wrinkle volume change rate of 50 days=100% (facial fishtail wrinkle volume of 50 days-facial fishtail wrinkle volume before use)/facial fishtail wrinkle volume before use.
Skin elasticity change rate test: each group of subjects washed the face with clear water before testing, and then tested the skin elasticity R2 index at the cheeks of the subjects using a skin analysis tester (MPA 580 of CK, germany), wherein a larger measurement of R2 represents a better skin elasticity. The skin elasticity R2 was measured for 20 days before, 50 days after, and after each group was tested using the test sample. Calculating the skin elasticity change rate of the subjects for 20 days and the skin elasticity change rate of 50 days, and taking an average value as the average skin elasticity change rate of each group; for example, the change rate of skin elasticity for 20 days=100% (skin elasticity R2 for 20 days-skin elasticity R2 before use)/skin elasticity R2 before use, and the change rate of skin elasticity for 50 days=100% (skin elasticity R2 for 50 days-skin elasticity R2 before use)/skin elasticity R2 before use of the subject.
The results are shown in Table 1.
Table 1: anti-aging Effect test
As can be seen from the test results in table 1, the composition of the present invention has excellent anti-aging effect, the composition can reduce the ratio of the facial fish tail volume to 7.62% in 20 days, and the composition can reduce the ratio of the facial fish tail volume to 18.35% in 20 days; the proportion of the skin elasticity can be increased by 3.81% after 20 days of use, and the proportion of the skin elasticity can be increased by 13.59% after 50 days of use.
As can be seen from comparison of the test samples 1, 3 and 4, the both of the boscalid and the ethandine can obviously enhance the skin anti-aging effect, and have synergistic effect of promoting the skin to remove wrinkles and increase skin elasticity.
Test samples 1 and 5-8 show that the combination of the polyglycerol-3-dicoleate and the PPG-2-isodecyl polyether-12 in the composition can obviously enhance the anti-aging effect of the composition, and the combination of the polyglycerol-3-dicoleate and the PPG-2-isodecyl polyether-12 can ensure that active ingredients such as anti-aging and moisturizing of the composition are efficiently absorbed by skin and delivered to the deep layer of the skin, so that better effects are exerted, and the anti-aging effect of the composition is enhanced. And when the mass ratio of the two is (0.8-1.3): 1, the composition has better effect of removing wrinkles and increasing skin elasticity.
As can be seen from the comparison of test samples 1, 9, 10, the combination of the polyglycerol-3-dicoleate and PPG-2-isodecyl polyether-12 of the invention provides a better anti-aging effect than other components, such as TWEEN-60, APG-0810.
3. Moisture effect test
The moisturizing effect is characterized by the moisture content increase rate of the facial skin.
The test object: selecting a plurality of subjects aged 30-55 years old, randomly dividing the subjects into 2 groups of 10 subjects (5 men and 5 women); each group of subjects had no dermatological disease, dry skin and no significant differences in skin moisture content.
Use of test samples: the subjects used 1.5g of the test sample on the face and smeared evenly, before using the test sample, the face was cleaned with clear water and then wiped dry.
The testing steps are as follows: each group of subjects was measured for facial skin moisture content using a skin moisture tester prior to use of the test sample. Then, the moisture content of the facial skin of the test samples for 3 hours and 8 hours is measured; then calculating the water content change rate of the facial skin after 3h and 8h use; the calculation formula is as follows: 3h facial skin moisture content change rate = 100% > (3 h facial skin moisture content-use front facial skin moisture content)/use front facial skin moisture content, 8h facial skin moisture content change rate = 100% > (8 h facial skin moisture content-use front facial skin moisture content)/use front facial skin moisture content, then the average facial skin moisture content change rate for each group of subjects was calculated. The results are shown in Table 2.
Table 2: moisture effect test
As shown in the test results of Table 2, the composition of the present invention has excellent moisturizing effect, and the moisture content of the skin can be increased to 41.38% in 3 hours and 30.12% in 8 hours.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (10)
1. An anti-aging composition comprising boscalid, ecadotene, ergothioneine, comprising: 0.2-2.5 parts of boscalid, 0.3-2.2 parts of ecadotene, 0.3-2.6 parts of ergothioneine, 0.2-1.5 parts of tea extract, 0.2-1.7 parts of rhodiola rosea extract, 3-10 parts of trimyristate glycerol, 2-7 parts of isopropyl palmitate, 2-6.5 parts of glycerin, 2-7 parts of beta-glucan, 2-6 parts of propylene glycol, 1.2-3.5 parts of polyglycerol-3-cocoate, 1.1-3.2 parts of PPG-2-isodecyl polyether-12, 0.08-0.5 part of phenoxyethanol and 50-80 parts of water; the parts are calculated by mass parts.
2. An anti-aging composition comprising boscalid, ecalciferon, ergothioneine according to claim 1, comprising: 0.5-2 parts of boscalid, 0.4-2 parts of ecalciferol, 0.5-2.3 parts of ergothioneine, 0.3-1.2 parts of tea extract, 0.4-1.5 parts of rhodiola rosea extract, 4-9 parts of trimyristate, 3-7 parts of isopropyl palmitate, 3-6 parts of glycerol, 2.5-6 parts of beta-glucan, 2.5-5.5 parts of propylene glycol, 1.5-3.2 parts of polyglycerol-3-dicarbamate, 1.2-3 parts of PPG-2-isodecyl polyether-12, 0.1-0.5 part of phenoxyethanol and 55-75 parts of water.
3. The anti-aging composition comprising boscalid, ecadotril, ergothioneine according to claim 1, wherein the boscalid is used in an amount of 0.6-1.8 parts.
4. The anti-aging composition comprising boscalid, ethandin, ergothioneine according to claim 1, wherein the amount of ethandin is 0.5-1.6 parts.
5. An anti-aging composition comprising boscalid, ecalcine, ergothioneine according to claim 1, wherein the ergothioneine is used in an amount of 0.6-2.2 parts.
6. The anti-aging composition comprising boscalid, ethandine, ergothioneine according to claim 1, wherein the mass ratio of boscalid to ethandine is (1.1-1.5): 1.
7. The anti-aging composition containing boscalid, ethandine, ergothioneine according to claim 1, wherein the mass ratio of polyglycerol-3-dicoleate to PPG-2-isodecyl polyether-12 is (0.8-1.3): 1.
8. A process for the preparation of an anti-aging composition comprising boscalid, ecalciferon, ergothioneine according to any of claims 1-7, comprising the steps of:
(1) Weighing the raw materials;
(2) Adding water into a reaction kettle, heating, adding glycerol trimyristate, isopropyl palmitate, glycerol, beta-glucan, propylene glycol, polyglycerol-3-dicarbamate and PPG-2-isodecyl polyether-12, and stirring to obtain a mixture;
(3) Cooling the mixture obtained in the step (2), adding the boscalid, the ethandine, the ergothioneine, the tea extract, the rhodiola rosea extract and the phenoxyethanol, and continuously stirring to obtain the composition.
9. The method of preparing as claimed in claim 8, wherein: the temperature of the step (2) is 35-85 ℃.
10. The method of preparing as claimed in claim 8, wherein: the temperature of the cooling in the step (3) is 10-34 ℃.
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