CN116617144B - Moisturizing and repairing composition containing collagen and preparation method thereof - Google Patents
Moisturizing and repairing composition containing collagen and preparation method thereof Download PDFInfo
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- CN116617144B CN116617144B CN202310922114.0A CN202310922114A CN116617144B CN 116617144 B CN116617144 B CN 116617144B CN 202310922114 A CN202310922114 A CN 202310922114A CN 116617144 B CN116617144 B CN 116617144B
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Abstract
The invention discloses a moisturizing and repairing composition containing collagen and a preparation method thereof, belonging to the technical field of cosmetics. The moisturizing repair composition comprises collagen, modified sodium hyaluronate, eucalyptus extract, cardamom extract, glycerol and water; the preparation method comprises the steps of dissolving modified sodium hyaluronate in water at 45-55 ℃, adding collagen peptide, eucalyptus extract and cardamom extract under stirring, cooling the obtained composition to room temperature, adding glycerol, and uniformly stirring. The moisturizing repair composition provided by the invention takes the plant extract as an active component, so that the use of chemical products is avoided, the skin is not stimulated, and the moisturizing repair composition is safer to human bodies; in addition, the plant extract used in the invention not only can produce good skin repair effect, but also can promote the penetration of active ingredients such as collagen peptide into the skin, thereby exerting lasting moisturizing and adsorbing effects.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a moisturizing and repairing composition containing collagen and a preparation method thereof.
Background
Moisturizing is the most basic step in the beautifying process, has the skin with sufficient moisture, naturally transmits out the perfect texture of gloss, moisture, elasticity and transparency from inside to outside, and conversely, when the skin lacks water, the skin immunity is reduced, the stimulation degree is enhanced, various stimulation phenomena such as skin dryness, itching and the like can be caused, more serious skin cell atrophy can be caused, color spot deposition and skin keratinization can be formed, thereby causing the deterioration of skin texture, bringing not only the appearance lacking sense but also psychological crisis to people.
However, the use of skin care products is not limited to the fields of moisturizing and skin care, and extends to the field of adjuvant treatment of some skin disorders. Such as: skin diseases such as sensitive skin, cosmetic dermatitis, hormone-dependent dermatitis, acne, chloasma, atopic dermatitis and the like are mostly treated by external glucocorticoids or immunomodulators in the prior art, but the drugs have certain side effects, for example, skin atrophy, pigmentation and other skin problems can be caused by long-term use of the glucocorticoids.
Therefore, the development of a skin care product which not only has a moisturizing function but also can repair damaged skin is an important point of research by those skilled in the art.
Disclosure of Invention
In view of the above prior art, the present invention provides a moisturizing and repairing composition containing collagen to achieve the purpose of moisturizing and repairing skin.
In order to achieve the above purpose, the invention adopts the technical scheme that the moisturizing and repairing composition containing collagen comprises the following components in parts by mass:
10-30 parts of collagen, 5-15 parts of modified sodium hyaluronate, 0.5-1 part of eucalyptus extract, 1-3 parts of cardamom extract, 50-60 parts of glycerol and 100-120 parts of water;
the modified sodium hyaluronate is prepared through the following steps:
s1: extracting herba Menthae to obtain herba Menthae extract;
s2: mixing sodium hyaluronate with alkali liquor according to a mass ratio of 1:3-5 to obtain sodium hyaluronate solution, adding mint extract and acetic anhydride into the sodium hyaluronate solution, uniformly stirring, reacting at 25-40 ℃ for 8-16 h, and regulating the reaction system to be neutral.
On the basis of the technical scheme, the invention can be improved as follows.
Further, the moisturizing repair composition comprises the following components in parts by mass:
20 parts of collagen, 10 parts of modified sodium hyaluronate, 1 part of eucalyptus extract, 2 parts of cardamom extract, 55 parts of glycerin and 110 parts of water.
The beneficial effects of the invention adopting the technical scheme are as follows: the collagen in the components has good compatibility with skin, and an extremely thin film layer can be formed on the surface of the skin, so that the skin is plump and wrinkles are stretched; meanwhile, a large amount of hydrophilic groups in the collagen can be combined with water in the stratum corneum to form a reticular structure, so that moisture is locked, and the aim of moisture preservation is fulfilled; in addition, the collagen can also induce the construction of self tissues, and has obvious repairing and improving effects on soft tissue defects such as intradermal or subcutaneous tissue damage and the like.
The components also comprise Eucalyptus extract and fructus Amomi rotundus extract. Wherein, the eucalyptus extract is rich in pinene, bergamotene, cumic aldehyde and other substances, has excellent antibacterial and anti-inflammatory effects, and has good prevention and treatment effects on mange, neurodermatitis, eczema and the like. The cardamom extract is rich in various active ingredients such as cardamomin and alpinetin, so that the inside repair of the skin can be promoted, cells in the skin have more activity, the skin is more compact and full, the external resistance of the skin can be enhanced, and the damage of free radicals and the like to the cells can be reduced. In addition, the eucalyptus extract and the cardamom extract have excellent penetration promoting effect, and can promote the penetration of active ingredients in the moisturizing and repairing composition to the skin cuticle, thereby improving the moisturizing and repairing effect.
The components are also added with modified sodium hyaluronate, and the modified sodium hyaluronate is obtained by modifying mint extracts and acetic anhydride. Acetic anhydride is used for partially acylating sodium hyaluronate, acetyl is introduced into the sodium hyaluronate, so that the hydrophilic performance of the sodium hyaluronate is improved, and the modified sodium hyaluronate is endowed with excellent moisturizing performance; the mint extract contains a large amount of menthol, and can be used as a cross-linking agent to perform esterification reaction with non-acetylated carboxyl on hyaluronic acid, so that cross-linked and acetylated hyaluronic acid is obtained, has good affinity, and can form a stable moisturizing layer on the surface of skin after being smeared, so that a lasting moisturizing effect is exerted. In addition, the peppermint extract also comprises an antioxidant and a cooling component, so that the peppermint extract not only can keep the skin fresh, but also can reduce the generation of grease and stimulate the healthy growth of the skin.
Further, the mint extract is prepared by the following steps:
s1: mixing fresh mature mint leaves with grinding fluid according to a mass ratio of 1:1-3, grinding into slurry, and mixing talcum powder and 5-10wt% sodium chloride solution according to a feed liquid ratio of 1 g:30-40 mL to obtain the grinding fluid;
s2: mixing the slurry obtained in the step S1 with an enzymolysis liquid according to a volume ratio of 1:2-5, and carrying out enzymolysis for 4-8 hours at 25-40 ℃, wherein the enzymolysis liquid is a cellulose aqueous solution with a mass fraction of 1-3%;
s3: filtering the reaction liquid after enzymolysis, collecting filtrate, and leaching filter residues by using ethanol solution with the volume fraction of 75-80%; mixing the filtrate and the leaching solution, and concentrating until the volume is unchanged.
The invention adopts the further technical proposal and has the beneficial effects that: the mint leaves are ground by the sodium chloride solution, and the sodium chloride solution can regulate the osmotic pressure of cells in the grinding process, so that the effective substances in the cells can flow out more easily, and the content of the effective substances in the mint extract is improved.
Further, the molecular weight of the sodium hyaluronate is 10-15 ten thousand daltons, and the alkali liquor is sodium hydroxide solution with the concentration of 1-3wt%.
Further, the proportion relation among the mint extract, acetic anhydride and sodium hyaluronate solution is 1-3 g, 0.5-1 g and 5-10 mL.
Further, the eucalyptus extract is prepared by the following steps:
s1: drying fresh eucalyptus leaves until the water content is lower than 5%, and then crushing the eucalyptus leaves and sieving the crushed eucalyptus leaves with a 50-mesh sieve to obtain eucalyptus powder;
s2: carrying out Soxhlet extraction on eucalyptus powder by taking diethyl ether as an extracting agent;
s3: concentrating the extractive solution.
Further, the cardamon extract is prepared by the following steps:
s1: drying fructus Amomi rotundus, pulverizing, and sieving with 50 mesh sieve to obtain fructus Amomi rotundus powder;
s2: soxhlet extraction is carried out on the cardamon powder by taking petroleum ether as an extracting agent;
s3: concentrating the extractive solution.
The invention adopts the further technical proposal and has the beneficial effects that: the eucalyptus leaves and the cardamom are extracted by adopting a Soxhlet extraction method, so that the effective components such as fat-soluble components in the eucalyptus leaves and the cardamom can be extracted, the fat-soluble components are easier to be absorbed by skin, and a better moisturizing and repairing effect can be achieved.
Further, the collagen is recombinant collagen, such as recombinant type I collagen, recombinant type III collagen, and the like.
The invention also discloses a preparation method of the moisturizing repair composition, which comprises the following steps:
(1) Dissolving modified sodium hyaluronate in water at 45-55 ℃, and then adding collagen, eucalyptus extract and cardamom extract under the stirring condition;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
The beneficial effects of the invention are as follows:
1. the moisturizing repair composition provided by the invention takes the plant extract as an active component, so that the use of chemical products is avoided, the skin is not stimulated, and the moisturizing repair composition is safer to human bodies.
2. The plant extract used in the invention not only can produce good skin repair effect, but also can promote the penetration of active ingredients such as collagen and the like into the skin, thereby exerting lasting moisturizing and adsorbing effects.
3. According to the invention, the modified sodium hyaluronate is modified, so that the composition after being smeared can form a stable moisturizing layer on the surface of the skin, and the moisturizing effect is further improved.
Detailed Description
The following describes the present invention in detail with reference to examples.
Example 1
The moisturizing repair composition containing the collagen comprises the following components in parts by mass:
1-02 parts of recombinant type III collagen TTA, 10 parts of modified sodium hyaluronate, 1 part of eucalyptus extract, 2 parts of cardamom extract, 55 parts of glycerin and 110 parts of water.
Wherein the modified sodium hyaluronate is prepared through the following steps:
s1: extracting herba Menthae to obtain herba Menthae extract; the mint extraction method comprises the following steps:
SS1: mixing fresh mature mint leaves with grinding liquid according to a mass ratio of 1:2, grinding into slurry, and mixing the grinding liquid with talcum powder and sodium chloride solution with concentration of 5wt% according to a feed-liquid ratio of 1g:35 mL;
SS2: mixing the slurry obtained by the SS1 with an enzymolysis liquid according to the volume ratio of 1:4, and then carrying out enzymolysis for 6 hours at 30 ℃, wherein the enzymolysis liquid is a cellulose water solution with the mass fraction of 2%;
SS3: filtering the reaction liquid after enzymolysis, collecting filtrate, and leaching filter residues by using an ethanol solution with the volume fraction of 80%; mixing the filtrate and the leaching solution, concentrating until the volume is unchanged, and obtaining herba Menthae extract;
s2: mixing sodium hyaluronate with molecular weight of 10 kilodaltons with sodium hydroxide solution with concentration of 2wt% according to mass ratio of 1:4 to obtain sodium hyaluronate solution, adding peppermint extract and acetic anhydride into sodium hyaluronate solution according to the proportion of 2g:0.5g:6mL, uniformly stirring, reacting at 30 ℃ for 12h, and regulating the reaction system to be neutral to obtain the product.
The eucalyptus extract is prepared by the following steps:
s1: drying fresh eucalyptus leaves until the water content is lower than 5%, and then crushing the eucalyptus leaves and sieving the crushed eucalyptus leaves with a 50-mesh sieve to obtain eucalyptus powder;
s2: carrying out Soxhlet extraction on eucalyptus powder by taking diethyl ether as an extracting agent for 8 hours;
s3: concentrating the extractive solution.
The cardamon extract is prepared by the following steps:
s1: drying fructus Amomi rotundus, pulverizing, and sieving with 50 mesh sieve to obtain fructus Amomi rotundus powder;
s2: soxhlet extraction is carried out on the cardamon powder by taking petroleum ether as an extracting agent, and the extraction time is 10 hours;
s3: concentrating the extractive solution.
The moisturizing repair composition in this embodiment is prepared by the following steps:
(1) Dissolving modified sodium hyaluronate in 50deg.C water, and adding recombinant type III collagen TTA1-02, eucalyptus extract and fructus Amomi rotundus extract under stirring;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
Example 2
The moisturizing repair composition containing the collagen comprises the following components in parts by mass:
1-02 parts of recombinant type III collagen TTA, 5 parts of modified sodium hyaluronate, 0.5 part of eucalyptus extract, 3 parts of cardamom extract, 50 parts of glycerin and 100 parts of water.
Wherein the modified sodium hyaluronate is prepared through the following steps:
s1: extracting herba Menthae to obtain herba Menthae extract; the mint extraction method comprises the following steps:
SS1: mixing fresh mature mint leaves with grinding liquid according to a mass ratio of 1:3, grinding into slurry, and mixing the grinding liquid with talcum powder and sodium chloride solution with concentration of 5wt% according to a feed-liquid ratio of 1g:40 mL;
SS2: mixing the slurry obtained by the SS1 with an enzymolysis liquid according to the volume ratio of 1:2, and then carrying out enzymolysis for 8 hours at 25 ℃, wherein the enzymolysis liquid is a cellulose water solution with the mass fraction of 1%;
SS3: filtering the reaction liquid after enzymolysis, collecting filtrate, and leaching filter residues by using ethanol solution with the volume fraction of 75%; mixing the filtrate and the leaching solution, concentrating until the volume is unchanged, and obtaining herba Menthae extract;
s2: mixing sodium hyaluronate with molecular weight of 10 kilodaltons with sodium hydroxide solution with concentration of 3wt% according to mass ratio of 1:3 to obtain sodium hyaluronate solution, adding peppermint extract and acetic anhydride into sodium hyaluronate solution according to the proportion of 1g:0.5g:5mL, uniformly stirring, reacting at 25 ℃ for 16h, and regulating the reaction system to be neutral to obtain the product.
The eucalyptus extract is prepared by the following steps:
s1: drying fresh eucalyptus leaves until the water content is lower than 5%, and then crushing the eucalyptus leaves and sieving the crushed eucalyptus leaves with a 50-mesh sieve to obtain eucalyptus powder;
s2: carrying out Soxhlet extraction on eucalyptus powder by taking diethyl ether as an extracting agent for 10 hours;
s3: concentrating the extractive solution.
The cardamon extract is prepared by the following steps:
s1: drying fructus Amomi rotundus, pulverizing, and sieving with 50 mesh sieve to obtain fructus Amomi rotundus powder;
s2: soxhlet extraction is carried out on the cardamon powder by taking petroleum ether as an extracting agent, and the extraction time is 10 hours;
s3: concentrating the extractive solution.
The moisturizing repair composition in this embodiment is prepared by the following steps:
(1) Dissolving modified sodium hyaluronate in 45deg.C water, and adding recombinant type III collagen TTA1-02, eucalyptus extract and fructus Amomi rotundus extract under stirring;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
Example 3
The moisturizing repair composition containing the collagen comprises the following components in parts by mass:
1-02 parts of recombinant type III collagen TTA, 15 parts of modified sodium hyaluronate, 1 part of eucalyptus extract, 1 part of cardamom extract, 60 parts of glycerin and 120 parts of water.
Wherein the modified sodium hyaluronate is prepared through the following steps:
s1: extracting herba Menthae to obtain herba Menthae extract; the mint extraction method comprises the following steps:
SS1: mixing fresh mature mint leaves with grinding liquid according to a mass ratio of 1:1, grinding into slurry, and mixing talcum powder and 10wt% sodium chloride solution according to a feed-liquid ratio of 1g:30mL to obtain the grinding liquid;
SS2: mixing the slurry obtained by the SS1 with an enzymolysis liquid according to the volume ratio of 1:5, and then carrying out enzymolysis for 4 hours at 40 ℃, wherein the enzymolysis liquid is a cellulose water solution with the mass fraction of 3%;
SS3: filtering the reaction liquid after enzymolysis, collecting filtrate, and leaching filter residues by using an ethanol solution with the volume fraction of 80%; mixing the filtrate and the leaching solution, concentrating until the volume is unchanged, and obtaining herba Menthae extract;
s2: mixing sodium hyaluronate with molecular weight of 15 ten thousand daltons with sodium hydroxide solution with concentration of 3wt% according to mass ratio of 1:5 to obtain sodium hyaluronate solution, adding peppermint extract and acetic anhydride into sodium hyaluronate solution according to the proportion of 3g to 1g to 10mL, uniformly stirring, reacting at 40 ℃ for 8h, and regulating the reaction system to be neutral to obtain the product.
The eucalyptus extract is prepared by the following steps:
s1: drying fresh eucalyptus leaves until the water content is lower than 5%, and then crushing the eucalyptus leaves and sieving the crushed eucalyptus leaves with a 50-mesh sieve to obtain eucalyptus powder;
s2: carrying out Soxhlet extraction on eucalyptus powder by taking diethyl ether as an extracting agent for 12 hours;
s3: concentrating the extractive solution.
The cardamon extract is prepared by the following steps:
s1: drying fructus Amomi rotundus, pulverizing, and sieving with 50 mesh sieve to obtain fructus Amomi rotundus powder;
s2: soxhlet extraction is carried out on the cardamon powder by taking petroleum ether as an extracting agent, and the extraction time is 8 hours;
s3: concentrating the extractive solution.
The moisturizing repair composition in this embodiment is prepared by the following steps:
(1) Dissolving modified sodium hyaluronate in 50deg.C water, and adding recombinant type III collagen TTA1-02, eucalyptus extract and fructus Amomi rotundus extract under stirring;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
Comparative example 1
The moisturizing repair composition containing the collagen comprises the following components in parts by mass:
1-02 parts of recombinant type III collagen TTA, 10 parts of sodium hyaluronate (with a molecular weight of 10 kilodaltons), 1 part of eucalyptus extract, 2 parts of cardamom extract, 55 parts of glycerin and 110 parts of water.
Wherein, the preparation method of eucalyptus extract and cardamom extract is the same as in example 1.
The moisturizing repair composition in this comparative example was prepared by the following steps:
(1) Dissolving sodium hyaluronate in 50deg.C water, and adding recombinant type III collagen TTA1-02, eucalyptus extract and fructus Amomi rotundus extract under stirring;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
Comparative example 2
The moisturizing repair composition containing the collagen comprises the following components in parts by mass:
1-02 parts of recombinant type III collagen TTA, 10 parts of modified sodium hyaluronate, 1 part of benzoic acid, 2 parts of cardamom extract, 55 parts of glycerin and 110 parts of water.
Wherein, the preparation method of the modified sodium hyaluronate and the cardamom extract is the same as that of the example 1.
The moisturizing repair composition in this comparative example was prepared by the following steps:
(1) Dissolving sodium hyaluronate in 50deg.C water, and adding recombinant type III collagen TTA1-02, benzoic acid and fructus Amomi rotundus extract under stirring;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
Comparative example 3
The moisturizing repair composition containing the collagen comprises the following components in parts by mass:
1-02 parts of recombinant type III collagen TTA, 11 parts of modified sodium hyaluronate, 2 parts of cardamom extract, 55 parts of glycerol and 110 parts of water.
Wherein, the preparation method of the modified sodium hyaluronate and the cardamom extract is the same as that of the example 1.
The moisturizing repair composition in this comparative example was prepared by the following steps:
(1) Dissolving sodium hyaluronate in 50deg.C water, and adding recombinant type III collagen TTA1-02 and fructus Amomi rotundus extract under stirring;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
Comparative example 4
The moisturizing repair composition containing the collagen comprises the following components in parts by mass:
1-02 parts of recombinant type III collagen TTA, 10 parts of modified sodium hyaluronate, 1 part of eucalyptus extract, 2 parts of benzoic acid, 55 parts of glycerol and 110 parts of water.
Wherein the modified sodium hyaluronate and eucalyptus extract are prepared as in example 1.
The moisturizing repair composition in this comparative example was prepared by the following steps:
(1) Dissolving sodium hyaluronate in 50deg.C water, and adding recombinant type III collagen TTA1-02, eucalyptus extract and benzoic acid under stirring;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
Comparative example 5
The moisturizing repair composition containing the collagen comprises the following components in parts by mass:
1-02 parts of recombinant type III collagen TTA, 12 parts of modified sodium hyaluronate, 1 part of eucalyptus extract, 55 parts of glycerol and 110 parts of water.
Wherein the modified sodium hyaluronate and eucalyptus extract are prepared as in example 1.
The moisturizing repair composition in this comparative example was prepared by the following steps:
(1) Dissolving sodium hyaluronate in 50deg.C water, and adding recombinant type III collagen TTA1-02 and Eucalyptus extract under stirring;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
Experimental example 1: moisture effect test
The moisturizing performance of the moisturizing repair compositions prepared in the above examples and comparative examples was tested as follows:
1. number of human subjects: 160, females; age: the people within the age range of 25-60 years are divided into 8 groups, 20 people in each group, and the number of people in each group in the same age range is the same; 8 subgroups numbered 1 to 8 and numbered 1 to 3 respectively use the moisturizing repair compositions containing collagen in examples 1 to 3; the moisturizing repair compositions containing collagen in comparative examples 1 to 5 were used for the panels of numbers 4 to 8, respectively.
2. Test instrument: a skin moisture meter CM 825 was used to measure skin stratum corneum moisture content.
3. Test area: medial of the right hand forearm.
4. The testing method comprises the following steps: no product was used 2 days before the test site, and no water was allowed to contact for the first 2 hours. The inner side of the forearm was cleaned uniformly and wiped clean before the test. The subject was allowed to sit still for 30min in a laboratory with 50.+ -. 10% relative humidity at room temperature before testing, without drinking water, with forearm exposure. After the test has started, the test sample is applied to a latex finger cuff at a rate of 2mg/cm 2 The amount of (C) was applied to a test area of 3cm by 3cm, and the moisture content of the skin horny layer of the applied area was measured at test periods of 0h, 4h, 8h and 12h, and the average value of the moisture content of the skin horny layer of each group of 20 subjects was calculated, and the results are shown in Table 1.
TABLE 1 moisturizing Performance test results
Note that: MMV represents the moisture content of human skin.
As can be seen from Table 1, after 12 hours, the skin still has a high moisture content using the moisturizing repair composition of the present invention, indicating that the moisturizing repair composition of the present invention has an excellent long-lasting moisturizing effect.
Comparative example 1 did not modify sodium hyaluronate as compared to example 1, and was inferior in hydrophilicity and stability to the modified sodium hyaluronate of example 1, and failed to form a stable moisturizing layer on the skin surface, and failed to exert a long-lasting moisturizing effect.
Comparative example 2 and comparative example 3 lack eucalyptus extract in the composition compared to example 1, and the moisturizing composition is not able to penetrate effectively into the skin compared to example 1, resulting in poor moisturizing effect.
Comparative example 4 and comparative example 5 lack cardamom extract in the composition compared to example 1, and also, the moisturizing composition is not effectively penetrated into the skin compared to example 1, resulting in poor moisturizing effect.
Experimental example 2: skin repair effect test
The experimental method comprises the following steps: in addition, 160 subjects with hormonal dermatitis (mainly shown as reddish facial eggs and itching) of 20-50 years old are selected for application test, and the moisturizing repair composition prepared in the examples and the comparative examples is continuously used for 4 months to evaluate the skin repair efficacy. 160 persons are randomly divided into 8 groups, 20 persons in each group, and the number of persons in the same age group in each group is the same; 8 subgroups numbered 1 to 8 and numbered 1 to 3 respectively use the moisturizing repair compositions containing collagen in examples 1 to 3; the moisturizing repair compositions containing collagen in comparative examples 1 to 5 were used for the panels of numbers 4 to 8, respectively. The statistical results are shown in table 2 below.
The decision criteria are as follows:
the effect is shown: after the skin is checked, the symptoms of redness and itching completely disappear, the skin becomes smooth, and no inflammation exists;
the method is effective: the symptoms are obviously relieved after the use;
invalidation: the symptoms are not relieved or aggravated after use.
TABLE 2 skin repair Performance test results
As can be seen from table 2, the symptoms of hormonal dermatitis in all subjects were significantly reduced using the moisturizing repair composition of the present invention, indicating that the moisturizing repair composition of the present invention has excellent skin repair efficacy.
Comparative example 1, compared with example 1, did not modify sodium hyaluronate, not only resulted in poor moisturizing properties, but also lacked the active ingredient from peppermint, and could not effectively inhibit the production of oil and fat, thus resulting in poor skin repair effect.
Comparative example 2 and comparative example 3 are inferior to example 1 in that the eucalyptus extract is absent from the components, not only does the penetration of the active ingredient into the skin be difficult, but also the antibacterial and anti-inflammatory components derived from the eucalyptus extract are absent, thereby resulting in poor skin restoration effect.
Comparative example 4 and comparative example 5 were inferior to example 1 in that the extract of cardamom was absent from the components, and as such, not only resulted in difficulty in penetration of the active ingredient into the skin, but also in that the component from cardamom which promoted cell activity and was resistant to free radical damage was absent, resulting in poor skin repair.
While specific embodiments of the invention have been described in detail in connection with the examples, it should not be construed as limiting the scope of protection of the patent. Various modifications and variations which may be made by those skilled in the art without the creative effort are within the scope of the patent described in the claims.
Claims (6)
1. The moisturizing repair composition containing the collagen is characterized by comprising the following components in parts by mass:
10-30 parts of collagen, 5-15 parts of modified sodium hyaluronate, 0.5-1 part of eucalyptus extract, 1-3 parts of cardamom extract, 50-60 parts of glycerol and 100-120 parts of water;
the modified sodium hyaluronate is prepared through the following steps:
s1: extracting herba Menthae to obtain herba Menthae extract; the mint extract is prepared through the following steps:
SS1: mixing fresh mature mint leaves with grinding fluid according to a mass ratio of 1:1-3, and grinding into slurry, wherein the grinding fluid is obtained by mixing talcum powder and 5-10wt% sodium chloride solution according to a feed liquid ratio of 1 g:30-40 mL;
SS2: mixing the slurry obtained in the step S1 with an enzymolysis liquid according to a volume ratio of 1:2-5, and carrying out enzymolysis for 4-8 hours at 25-40 ℃, wherein the enzymolysis liquid is a cellulose aqueous solution with a mass fraction of 1-3%;
SS3: filtering the reaction liquid after enzymolysis, collecting filtrate, and leaching filter residues by using ethanol solution with the volume fraction of 75-80%; mixing the filtrate and the leaching solution, concentrating until the volume is unchanged;
s2: mixing sodium hyaluronate with alkali liquor according to a mass ratio of 1:3-5 to obtain sodium hyaluronate solution, adding mint extract and acetic anhydride into the sodium hyaluronate solution, uniformly stirring, reacting at 25-40 ℃ for 8-16 h, and regulating a reaction system to be neutral to obtain the sodium hyaluronate; the molecular weight of the sodium hyaluronate is 10-15 ten thousand daltons, and the alkali liquor is sodium hydroxide solution with the concentration of 1-3wt%; the proportion relation among the mint extract, acetic anhydride and sodium hyaluronate solution is 1-3 g, 0.5-1 g and 5-10 mL.
2. The moisturizing repair composition containing collagen according to claim 1, comprising the following components in parts by mass:
20 parts of collagen, 10 parts of modified sodium hyaluronate, 1 part of eucalyptus extract, 2 parts of cardamom extract, 55 parts of glycerin and 110 parts of water.
3. The collagen-containing moisturizing repair composition of claim 1, wherein the eucalyptus extract is prepared by:
s1: drying fresh eucalyptus leaves until the water content is lower than 5%, and then crushing the eucalyptus leaves and sieving the crushed eucalyptus leaves with a 50-mesh sieve to obtain eucalyptus powder;
s2: carrying out Soxhlet extraction on eucalyptus powder by taking diethyl ether as an extracting agent;
s3: concentrating the extractive solution.
4. The collagen-containing moisturizing repair composition according to claim 1, wherein the cardamom extract is prepared by:
s1: drying fructus Amomi rotundus, pulverizing, and sieving with 50 mesh sieve to obtain fructus Amomi rotundus powder;
s2: soxhlet extraction is carried out on the cardamon powder by taking petroleum ether as an extracting agent;
s3: concentrating the extractive solution.
5. The collagen-containing moisturizing repair composition according to claim 1, wherein: the collagen is recombinant collagen.
6. The method for preparing the moisturizing repair composition containing collagen according to any one of claims 1 to 5, comprising the steps of:
(1) Dissolving modified sodium hyaluronate in water at 45-55 ℃, and then adding collagen, eucalyptus extract and cardamom extract under the stirring condition;
(2) Cooling the composition obtained in the step (1) to room temperature, then adding glycerol, and uniformly stirring to obtain the composition.
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