KR20200068993A - Functional cosmetic composition comprising oxygen - Google Patents

Abstract

The present invention relates to a cosmetic composition having a function of skin whitening, wrinkle reduction and moisturizing. The cosmetic composition of the present invention has an excellent whitening effect by ameliorating hyperpigmentation and improving skin tone, has an excellent wrinkle reduction effect through reduction of wrinkles around the eyes, and improvement of skin density, skin elasticity and elasticity restoration, has an excellent skin moisturizing effect through an increase in skin moisture content, improvement of skin moisture barrier, and relief of pruritus caused by drying, and thus can be used as a functional cosmetic composition for skin whitening, wrinkle reduction and moisturizing.

Description

Functional cosmetic composition containing oxygen {FUNCTIONAL COSMETIC COMPOSITION COMPRISING OXYGEN}

The present invention relates to a cosmetic composition having the functionality of skin whitening, wrinkle improvement and moisturizing.

Human skin is a primary barrier that protects the human body from various stimuli originating from the external environment. It is also a protective barrier that prevents moisture from the body, which is absolutely necessary to maintain bioactivity, from escaping to the outside. The human body is inevitably exposed to a relatively dry environment most of the time compared to the skin. Because of this, the skin, especially the stratum corneum, has a variety of substances that store water and prevent evaporation. have. The two most important factors for the moisturizing function of the stratum corneum are: First, the intercellular lamellar lipids act as a film to prevent evaporation of moisture, and as another factor, the decomposition of filaggrin in the keratinocytes. A natural moisturizing factor composed mainly of products functions to hold moisture within the stratum corneum. In various skin diseases or aged skin, the function of these two main factors is deteriorated and the moisturizing condition of the skin deteriorates, and dryness can easily occur. In this case, the moisturizer is a very important treatment to relieve pruritus or other skin abnormalities caused by dryness. It can be a means. In addition, the moisture in the stratum corneum helps to maintain the skin barrier in a healthy state by helping to maintain the activity of enzymes having various physiological activities, so the moisturizer serves to keep the skin of normal people healthy as well as dry skin. can do.

Aging is an irreversible phenomenon that is a morphological, biochemical, and physiological change process that proceeds in parallel with the overall aging of human subjects. Unlike aging in other organs or organs in the body, skin aging is a genetically determined process of aging (Intrinsic aging) (Braverman IM et al.: J. Invest. Dermatol., 78, 434-443 (1982)) In addition, it involves the process of extrinsic aging by extrinsic persons associated with ultraviolet radiation, smoking and other lifestyles (Gilchrest BA: J. Am. Acad. Dermatol., 21, 610-613 (1989)). Skin aging due to exogenous and endogenous aging is manifested by clinical features such as solar elastosis, dyschromatosis and increased roughness and skin wrinkle formation. The anti-aging treatment in the skin beauty area focuses on the improvement of individual phenomena of skin aging. In addition to medical procedures or surgical treatment, the anti-aging mechanism of functional products mainly in the recent cosmetic area also shares the same context. can see. The wrinkle improvement effect by cosmetics is based on the effect of improving the dermis layer by various active ingredients in addition to the temporary effect by moisturization by moisturizing factors, and growth factor ingredients such as retinol, vitamin C, and EGF, which are the raw materials for typical wrinkle improvement cosmetics. They are well known to show wrinkle improvement efficacy by increasing collagen angiogenesis from human dermal fibroblasts. The skin has both elastic and solid properties as well as viscous fluid properties, and the mechanical properties of such skin are called viscoelasticity. In the case of elasticity, elasticity is caused by the structure of the connection between collagen and elastin, and in the case of viscosity, it is caused by a fluid component composed of extracellular matrixes including hyaluronic acid and the like. Occurs. The viscoelasticity of the skin provides additional movement to the skin deformation due to elasticity, thereby allowing the skin to be more effectively protected against external forces.

On the other hand, there are various factors that determine skin color, such as melanin derived from melanocytes, peripheral blood vessels and hemoglobin, thickness of the stratum corneum, carotene, and the like, melanin plays the most important role. Melanin can be roughly divided into two types. First, there are eumelanin, which causes brown or black to appear on the skin or hair, and its modification, oxymelanin. The other is pheomelanin, which gives the hair a light yellow to reddish brown color, and its modification. There is trichochrome. The number of melanin cells is constant regardless of ethnicity and skin color, and the skin color is determined by the number, size, degree of melaninization, distribution of melanin bodies, and decomposition of melanin bodies in keratinocytes. Important factors for determining dark and white skin are the size of melanocytes and the distribution pattern in keratinocytes. Black skin forms large melanocytes and is dispersed individually in the cytoplasm, but small melanocytes of white skin are membranes. It is contained in a phagocytic body surrounded by. Skin color, which is genetically determined by race, is altered by being influenced by the production of melanin pigment by the effects of hormones such as melanocyte stimulating hormone, adrenal cortical stimulating hormone, estrogen, bolotropin, thyroid hormone and androgen in addition to ultraviolet rays. You may. Skin whitening is an important cosmetic issue for Asian women such as Korea, and since bright skin has long been regarded as a condition of beauty, cosmetics that brighten the skin color are widely used, and representative ones are whitening functional cosmetics.

An object of the present invention is to provide a cosmetic composition for skin whitening.

In addition, an object of the present invention is to provide a cosmetic composition for improving or moisturizing skin wrinkles.

In order to solve the above problems, the present invention provides a cosmetic composition for skin whitening.

In addition, the present invention provides a cosmetic composition for improving or moisturizing skin wrinkles.

The cosmetic composition of the present invention has excellent whitening effect through improvement of hyperpigmentation and improvement of skin tone by including oxygen and various substances in the composition, and excellent wrinkle improvement through improvement of eye wrinkles, skin density, epidermal elasticity and elastic restoration It has an effect, has an excellent skin moisturizing effect through an increase in skin moisture content, improvement of skin moisture barrier, and relief of pruritus caused by drying, and thus can be used as a functional cosmetic composition for skin whitening, wrinkle improvement and moisturizing.

1 is a diagram showing the skin color index (M-value) confirmed by Mexameter.
Figure 2 is a graph showing the change in skin color index (M-value) change at the test site to which the cosmetic composition of the present invention is applied.
3 is a view showing the results of visual evaluation of the hyperpigmentation improvement effect of the cosmetic composition of the present invention.
Figure 4 is a graph showing the results of visual evaluation of the hyperpigmentation improvement effect of the cosmetic composition of the present invention.
5 is a view showing the subjective evaluation results of the subject for the improvement effect of hyperpigmentation of the cosmetic composition of the present invention.
6 is a view showing the L-value of the cosmetic composition of the present invention confirmed the skin tone improvement effect through a Chromameter.
7 is a graph confirming the skin tone improvement effect of the cosmetic composition of the present invention as skin brightness (L-value).
8 is an indentation index confirming the effect of improving the eye wrinkles of the cosmetic composition of the present invention through Antera 3D.
9 is an eye wrinkle index index graph confirming the eye wrinkle improvement effect of the cosmetic composition of the present invention through Antera 3D.
FIG. 10 is a result of skin elasticity (R7:Ur/Uf) confirming the effect of improving the skin elasticity and elastic restoring power of the cosmetic composition of the present invention through a cutometer.
11 is a result of the elastic restoring force confirming the effect of improving the skin elasticity and elastic restoring force of the cosmetic composition of the present invention through a cutometer.
FIG. 12 is a graph of epidermal elasticity (R7:Ur/Uf) confirming the effect of improving the elasticity and elastic resilience of the cosmetic composition of the present invention through a cutometer.
13 is a graph showing the elastic resilience of the cosmetic composition of the present invention, confirming the effect of improving the resilience and elastic resilience through a cutometer.
14 is a result of confirming the effect of improving the skin density of the cosmetic composition of the present invention through Ultrasound.
15 is a graph showing the skin density of the cosmetic composition of the present invention through the Ultrasound.
FIG. 16 is a result of the moisture content of the skin (stratum corneum) in which the moisturizing and drying effect of the cosmetic composition of the present invention is confirmed through a corneometer.
17 is a subjective evaluation result by a subject on the effect of alleviating the feeling of irritation by moisturizing and drying the skin of the cosmetic composition of the present invention.
18 is a graph of the moisture content of the skin (stratum corneum) in which the cosmetic composition of the present invention confirmed the effect of alleviating the feeling of irritation caused by skin moisturizing and drying through a corneometer.
19 is a graph of subjective evaluation results by a subject on the effect of alleviating the feeling of irritation by moisturizing and drying the skin of the cosmetic composition of the present invention.
20 is a result of skin (corneal layer) moisture content confirmed through a corneometer to improve the skin moisture content of the cosmetic composition of the present invention.
21 is a graph of the skin (corneal layer) moisture content of the cosmetic composition of the present invention confirmed through the corneometer.
22 is a result of transdermal moisture loss confirming the effect of improving the skin moisture barrier of the cosmetic composition of the present invention through Tewameter TM-300.
23 is a graph showing transdermal moisture loss through the Tewameter TM-300 showing the effect of improving the skin moisture barrier of the cosmetic composition of the present invention.
24 is a view showing the component composition ratio of the cosmetic composition of the present invention.

Hereinafter, the present invention will be described in detail with reference to the accompanying drawings as an embodiment of the present invention. However, the following embodiments are presented as examples of the present invention, and when it is determined that a detailed description of a technique or configuration well known to those skilled in the art may unnecessarily obscure the subject matter of the present invention, the detailed description may be omitted. , Thereby, the present invention is not limited. The present invention is capable of various modifications and applications within the scope of the claims and the equivalents interpreted therefrom.

In addition, terms used in the present specification (terminology) are terms used to properly represent a preferred embodiment of the present invention, which may vary according to a user, an operator's intention, or customs in the field to which the present invention pertains. Therefore, definitions of these terms should be made based on the contents throughout the specification. Throughout the specification, when a part “includes” a certain component, it means that the component may further include other components, not to exclude other components, unless otherwise stated.

Throughout this specification,'%' used to indicate the concentration of a specific substance is (w/w)% for solid/solid, (w/v)% for solid/liquid, and unless otherwise specified. The liquid/liquid is (v/v) %.

In one aspect, the present invention is oxygen, palmitoyl tripeptide-5, tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate, magnesium chloride, butylene glycol, palmitoyl tripeptide-1, palmitoyltetra Peptide-7, acetylhexapeptide-8, maca root extract, hydrolyzed vegetable protein, sunflower seed oil, white lupine seed extract and hydrolyzed avocado protein as active ingredients, for skin whitening, wrinkle improvement Or it relates to a moisturizing cosmetic composition.

In one embodiment, oxygen, palmitoyl tripeptide-5, tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate, magnesium chloride, butylene glycol, palmitoyl tripeptide-1, palmitoyltetrapeptide- 7, acetylhexapeptide-8, maca root extract, hydrolyzed vegetable protein, sunflower seed oil, white lupine seed extract and hydrolyzed avocado protein may be included in 0.01 to 10 parts by weight of 100 parts by weight of the cosmetic composition .

In one embodiment, the cosmetic composition 100 parts by weight of oxygen is 0.000001 to 0.00001 parts by weight, palmitoyl tripeptide-5 is 0.0000001 to 0.00001 parts by weight, tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate is 0.000001 To 0.00001 parts by weight, magnesium chloride is 0.0000001 to 0.000001 parts by weight, butylene glycol is 0.00001 to 0.0001 parts by weight, palmitoyl tripeptide-1 is 0.00000005 to 0.000001 parts by weight, palmitoyltetrapeptide-7 is 0.00000001 to 0.0000001 parts by weight , Acetylhexapeptide-8 is 0.0000001 to 0.000001 parts by weight, maca root extract is 0.00001 to 0.0001 parts by weight, hydrolyzed vegetable protein is 0.0001 to 0.001 parts by weight, sunflower seed oil is 0.00001 to 0.005 parts by weight, white lupine seed extract Silver 0.001 to 0.1 parts by weight and the hydrolyzed avocado protein may be included in 0.0001 to 0.001 parts by weight.

In one embodiment, the cosmetic composition of the present invention is added to extract yarrow extract, motherwort extract, mallow extract, lemon balm leaf extract, peppermint leaf extract, cowslip extract, tailweed extract, bisabolol, glutathione and saccharide hydrolysate It can contain as.

In one embodiment, the present composition may be prepared using purified water containing oxygen by additionally dissolving oxygen in purified water. By adding oxygen to the composition, it can actively induce metabolism, induce elastic skin improvement, and furthermore, it promotes activation of active ingredients in the composition as well as the functionality of oxygen itself, thereby maximizing the function with functional cosmetics I can do it.

In one embodiment, the formula of palmitoyl tripeptide-5 may be represented by Formula 1 below, and may be represented by palmitoyl-Lys-Val-Lys-OH:

In one embodiment, the chemical formula of palmitoyl tripeptide-1 can be represented by the following Chemical Formula 2, and can be represented by Palmitoyl-glycyl-histidyl-lysine:

In one embodiment, the formula of palmitoyl tetrapeptide-7 may be represented by Formula 3 below, and may be represented by Pal-Gly-Gln-Pro-Arg-OH:

In one embodiment, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate can be represented by Formula 4:

In one embodiment, the maca root extract is dispersed for 5 hours in maca root powder in amylase-containing water (pH5, 50°C), and then reacted at 60°C at pH8 for 1 hour by adding protease (alcalase). And inactivated the enzymes at 90° C. for 20 minutes, and then filtered to a pore size of 1 μm, but is not limited thereto.

In one embodiment, the hydrolyzed vegetable protein may be an Acacia macrostachya seed extract, and the Acacia macrostaki seed extract crushes the Acacia macrostaki seeds, pH 3 to 9 at 20 to 90°C. After dispersing in water, the dispersion may be prepared by enzymatic hydrolysis, but is not limited thereto. Most of the prepared Acacia macrostark seed extract contains, or substantially, peptides and monosaccharides (sugars).

In one embodiment, the hydrolyzed avocado protein is prepared by drying the avocado, cold compressing it, degreasing it with ethanol, hydrolyzing it with cellulase for 4 to 6 hours, protease for 1 to 3 hours, and concentrating and filtering. However, it is not limited thereto.

In one embodiment, the white lupine seed extract may contain, but is not limited to, lupeol extracted from the Sweet white Lupin seed coating.

In one embodiment, acetylhexapeptide-8 may have an anti-wrinkle effect, and is a component synthesized from a peptide part having a major function in botox (acetyl glutamyl-glutamyl-methyonyl-glutamyl-arginyl-arginulamide)

In one embodiment, the cosmetic composition of the present invention may further include raspberry seed oil/tocopheryl succinate aminopropanediol ester, edelweiss callus culture extract, rock samfire callus culture filtrate, or lactobacillus milk fermentation filtrate. .

In one embodiment, the cosmetic composition of the present invention is raspberry seed oil / tocopheryl succinate amino propane diol ester, edelweiss callus culture extract, rock samfire callus culture filtrate or lactobacillus milk fermentation filtrate 100 parts by weight of the cosmetic composition To 0.001 to 1 part by weight.

In one embodiment, the raspberry seed oil/tocopheryl succinate aminopropanediol ester may be a lipophilic material obtained through an enzymatic reaction without using a solvent of a strawberry seed oil and vitamin E succinate, omega 6 and 3 Raspberry seed oil containing high concentration of omega 6 and 3 in high concentration to nourish the skin, has anti-inflammatory and stress relief, and strengthens the skin barrier function, vitamin E succinate protects the skin and tissues It has the effect of regeneration.

In one embodiment, the edelweiss callus culture extract can be prepared by germinating the seeds of edelweiss and transferring the germinated plants to induce and propagate the callus, followed by liquid and mass cultivation, harvesting, drying and extraction. In addition, the Edelweiss callus can increase the amount of Chlorogenic acid using TOP-C2X. More specifically, Edelweiss callus culture can be treated with elicitor X to increase the amount of Chlorogenic acid.

In one embodiment, the Roxemfire callus culture filtrate may be prepared by culturing and filtering plant stem cells of Crithmum maritimum .

In one embodiment, bisabolol can be extracted from a candeia tree native to Brazil, has a strong melanin synthesis inhibitory effect at melanocytes, and can be used as a whitening material, and the bisabolol of the present invention is alpha-bisa It can be a ball.

In one embodiment, the cosmetic composition of the present invention has a moisturizing effect glycerin (Glycerin), propanediol (Propanediol), caprylic / capric triglyceride (Caprylic / Capric Triglyceride), meadow form seed oil (Limnanthes Alba (Meadowfoam ) Seed Oil), Coconut Palm Oil (Cocos Nucifera (Coconut) Oil), Sodium Hyaluronate, Shea Butter (Butyrospermum Parkii (Shea) Butter), Drumstick Pterygosperma Seed Extract, Olive Oil (Olea Europaea (Olive) Fruit Oil), Squalane, Ceramide NP, Cholesterol and Phytosphingosine; Hydrolyzed Hibiscus Esculentus Extract and Adenosine with anti-wrinkle effect through elasticity effect; And it may further include one or more selected from the group consisting of niacinamide having a whitening effect (Niacinamide).

In one embodiment, the cosmetic composition of the present invention as a component constituting the formulation cyclopentasiloxane (Cyclopentasiloxane), 1,2-hexanediol (1,2-Hexanediol), cetearyl oleate (Cetearyl Olivate), sorbitan Sorbitan Olivate, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Cyclohexasiloxane, Diisostearyl Malate, Polyglycerol Polyglyceryl-2 Stearate, Sodium Stearoyl Glutamate, Glyceryl Stearate, Sodium Polyacrylate, Hydroxyacetophenone, Acrylic Late/C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Glycol, Tromethamine, Ethylhexylglycerin, Polymethylsilsesquique Polymethylsilsesquioxane, Silica, Hydrogenated Lecithin, Maltodextrin, Tocopherol, Polysorbate 20, Cetyl Alcohol, Behenyl Alcohol One or more selected from the group consisting of Behenyl Alcohol, Cetearyl Alcohol, Stearyl Alcohol, Xanthan Gum, Disodium EDTA and Carbomer It may further include.

In one embodiment, the cosmetic composition of the present invention may further include a fragrance and gold (CI 77480).

The term "extract" used in the present invention means an active ingredient separated from a natural product, that is, a substance exhibiting a desired activity. The extract may be obtained by an extraction process using water, an organic solvent or a mixed solvent thereof, and includes all forms of extracts or dried powders thereof. In addition, the extract includes fractions of the extract that has been subjected to the extraction process. The method of extracting the extract is not particularly limited, and may be, for example, agitated extraction, shaking extraction, hot water extraction, cold needle extraction, reflux cooling extraction, or ultrasonic extraction. As the extraction solvent, water, a polar solvent such as a lower alcohol of C ₁ -C ₄ or a non-polar solvent such as hexane, chloroform, dichloromethane or ethyl acetate, or a mixture of two or more of them may be used.

The cosmetic composition of the present invention may be prepared by including the cosmetically effective amount of the above-described active ingredients of the present invention (cosmetically effective amount) and a cosmetically acceptable carrier.

The term "cosmetic effective amount" as used herein means an amount sufficient to achieve the whitening, wrinkle improvement or moisturizing efficacy of the composition of the present invention described above.

The appearance of the cosmetic composition contains a cosmetic or dermatologically acceptable medium or base. These are all formulations suitable for topical application, e.g. solutions, gels, solids, dough anhydrous products, emulsions, suspensions, microemulsions, microcapsules, microgranules, or ionic (liposomes) obtained by dispersing an oil phase in an aqueous phase, and It can be provided in the form of a non-ionic vesicle dispersant, or in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. These compositions can be prepared according to conventional methods in the art. The composition according to the invention can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

The cosmetic composition according to an embodiment of the present invention is not particularly limited in its formulation, for example, softening makeup, converging makeup, nutrient makeup, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing It can be formulated into cosmetics such as cream, cleansing foam, cleansing water, pack, powder, body lotion, body cream, body oil, and body essence.

When the formulation of the cosmetic composition of the present invention is a paste, cream, or gel, animal fibers, plant fibers, wax, paraffin, starch, tracant, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide, etc. This can be used.

When the formulation of the cosmetic composition of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in the case of a spray, additionally, chlorofluorohydro Propellants such as carbon, propane/butane or dimethyl ether.

When the formulation of the cosmetic composition of the present invention is a solution or emulsion, a solvent, a solvating agent or an emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, and propylene Glycols, 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.

When the formulation of the cosmetic composition of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol as a carrier component, an ethoxylated isostearyl alcohol, a suspension agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or trakant, etc. can be used.

When the formulation of the cosmetic composition of the present invention is surfactant-containing cleansing, as the carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate , Fatty acid amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linoline derivatives or ethoxylated glycerol fatty acid esters and the like.

The cosmetic composition of the present invention includes skin, lotion, cream, essence, pack, foundation, color cosmetics, sun cream, two-way cake, face powder, compact, makeup base, skin cover, eye shadow, lipstick, lip gloss, lip fix, eyebrow pencil , It can be applied to cosmetics such as lotion and detergents such as shampoo and soap.

The cosmetic composition according to an embodiment of the present invention may further include a functional additive and a component included in a general cosmetic composition in addition to the extract containing the active ingredient. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingo lipids, and seaweed extract.

The cosmetic composition of the present invention may also contain, in addition to the functional additives, components contained in a general cosmetic composition as necessary. Other ingredients included include oils and fats, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavors, blood circulation Accelerators, cooling agents, limiting agents, purified water, and the like.

The present invention will be described in more detail through the following examples. However, the following examples are only intended to materialize the contents of the present invention, and the present invention is not limited thereto.

Example. Preparation of functional cosmetic composition containing oxygen

Palmitoyl Tripeptide-5, tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate, magnesium chloride, butylene glycol, palmitoyl tripeptide-5, palmitoyl tetrapeptide as main ingredients -7, Acetyl Hexapeptide-8, Lepidium Meyenii Root Extract, Hydrolyzed Vegetable Protein, Sunflower Seed Oil, White Lupinus Albus Seed Extract and Hydrolyzed Avocado Protein, Ingredients Raw raspberry seed oil/tocopheryl succinate aminopropanediol ester, edelweiss callus culture extract, rock samfire callus culture filtrate and lactobacilli milk fermentation filtrate were mixed and mixed. As an additional ingredient, Achillea Millefolium Extract, Alchemilla Vulgaris Extract, Malva Sylvestris (Mallow) Extract, Lemon Balm Leaf Extract, Peppermint Leaf Extract ( Mentha Piperita (Peppermint) Leaf Extract, Prisma Veris Extract, Veronica Officinali Extract, Bisabolol, Glutathione, Saccharide Hydrolysate Additive materials such as butylene glycol, sodium hyaluronate, glycerin, purified water, tocopherol, maltodextrin, 1,2-hexanediol, carbomer, polysorbate 20, ethylhexylglycerin, caprylyl glycol, etc. are mixed. Table 1 and Figure 24 by mixing the above materials in purified water in which oxygen was dissolved. A cream-formed cosmetic composition having a component composition ratio was prepared.

Specifically, the main ingredients palmitoyl tripeptide-5, tetradecylaminobutyroylvalylaminobutyric urea trifluoroacetate, magnesium chloride, butylene glycol, palmitoyl tripeptide-1, palmitoyltetrapeptide-7, Acetyl hexapeptide-8, maca root extract, hydrolyzed vegetable protein, sunflower seed oil, white lupine seed extract, and hydrolyzed avocado protein have the efficacy as shown in Table 2 below, and as an additive, raspberry seed oil/tocope Reel succinate aminopropanediol ester, edelweiss callus culture extract, rock samfire callus culture filtrate, and lactobacillus milk fermentation filtrate have the efficacy as shown in Table 3 below, and additional ingredients are yarrow extract, motherwort extract, marlow extract, Lemon balm leaf extract, peppermint leaf extract, cowslip extract, tailweed extract, bisabolol, glutathione, and saccharide hydrolyzate have the effects shown in Table 4 below.

Main material efficacy Palmitoyl tripeptide-5 Improves skin elasticity by promoting collagen synthesis in skin tissues in the body Tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate Improves skin elasticity by promoting collagen synthesis in skin tissues in the body Magnesium chloride Improves skin elasticity by promoting collagen synthesis in skin tissues in the body Butylene Glycol As a skin conditioning agent, it has the ability to retain moisture and improves skin moisturizing power Palmitoyl tripeptide-1 Improves skin elasticity by promoting collagen synthesis in skin tissues in the body Palmitoyl tetrapeptide-7 Improves skin elasticity by promoting collagen synthesis in skin tissues in the body Acetyl hexapeptide-8 Improves skin elasticity by promoting collagen synthesis in skin tissues in the body Maca root extract Wrinkle improvement and skin whitening by promoting cell activity Hydrolyzed vegetable protein Promote natural moisturizing factors in dry skin Sunflower seed oil The skin is composed of tissues similar to the main component of sebum, so it has good skin absorption and moisturizes by forming a thin film on the skin. White lupine seed extract Improve skin elasticity with skin conditioning ingredients Hydrolyzed Avocado Protein Helps improve oxidized skin from the external environment and promotes hyaluronic acid synthesis in the skin Oxygen Oxygen deficiency in the skin slows the process of skin breathing and metabolism and promotes skin aging. Therefore, by adding oxygen to the skin, it actively induces metabolism and induces elastic skin improvement. When the active ingredients are mixed using the purified water by dissolving oxygen in the purified water, not only the functionality of the oxygen itself but also the activation of the active ingredients in the composition is promoted to maximize the function as a functional cosmetic.

Absence efficacy Raspberry seed oil/tocopheryl succinate aminopropanediol ester Improves skin elasticity by promoting collagen synthesis in skin tissues in the body Edelweiss callus culture extract Improve skin elasticity with excellent antioxidant effect Rocksamfire callus culture filtrate Helps to improve skin tone and radiance and promotes skin cell differentiation Lactobacillus milk fermentation filtrate Improve skin elasticity and strengthen moisture

Additional material efficacy Yarrow extract Wrinkle improvement and skin whitening by promoting cell activity Our Lady Extract Wrinkle improvement and skin whitening by promoting cell activity Marlow extract Wrinkle improvement and skin whitening by promoting cell activity Lemon balm leaf extract Wrinkle improvement and skin whitening by promoting cell activity Peppermint leaf extract Wrinkle improvement and skin whitening by promoting cell activity Cowslip extract Wrinkle improvement and skin whitening by promoting cell activity Tailweed extract Wrinkle improvement and skin whitening by promoting cell activity Bisabolol Skin whitening according to the effect of inhibiting the activity of tyrosinase in the skin Glutathione Skin whitening according to the effect of inhibiting the activity of tyrosinase in the skin and antioxidant effect in the body Saccharide Hydrolysate (SACCHARIDE HYDROLYSATE) Prevents evaporation of skin moisture by forming a thin protective film on the skin

Experimental Example 1. Confirmation of whitening effect

1-1. Confirm the effect of improving hyperpigmentation

The effect of improving hyperpigmentation of the functional cosmetic composition prepared in the above example was confirmed by requesting to the Korea Dermatology Research Institute. Specifically, 21 subjects (a person who has been fully informed of the matters to be notified to the subject by the person in charge of the test or the person who has been delegated by the person responsible for the test, voluntarily completed and signed a consent form, including an acute, chronic body, including a disease After self-applying twice a day for 4 weeks twice a day in the morning and in the evening to healthy healthy people without disease and those who can be followed up during the test period, Mexameter (The Mexameter® MX 18, CK electronic GmbH, Germany) Instrument evaluation (This equipment measures the level of melanin and erythema of the skin by a reflex-based detector emitting three special special wavelengths of light, which are reflected from the skin and measured by the receiver in the detector. Melanin is measured by two wavelengths of light, and the absorption rate of light is different depending on the skin's melanin pigment. Using this light wavelength, different absorption rates of light can be captured and measured as melanin levels. (erythema) can also be determined by measuring the degree of light absorption of the skin using two different wavelengths of light.The results of melanin and erythema are numerically represented by M (Melanin) and E (Erythema) values, respectively. Subjective evaluation by, dermatological use safety evaluation and visual evaluation were performed. The degree of skin whitening (improvement of hyperpigmentation) was derived by Equation 1 below. The skin color index (M-value) confirmed through the device was shown in FIG. 1, and the statistical results thereof were shown in Table 5 below. In addition, the results of the visual evaluation were shown in FIG. 3, and the statistical results thereof were shown in Table 6 below. In addition, the subjective evaluation results of the subjects were shown in FIG. 5, and the statistical results thereof were shown in Table 7 below, and no particular adverse reaction was observed in all subjects.

* p <0.05, ** p <0.01, *** p <0.001

* p <0.05, ** p <0.01, *** p <0.001

As a result, from 2 weeks after the test, the skin pigment index (M-value) decreased at the test site where the functional cosmetic composition prepared in the above example was applied (1.72% after 2 weeks of application, 6.09 after 4 weeks of application compared to before the test) % Decrease) ( p <0.05) (FIG. 2 ), the visual evaluation value decreased ( p <0.05) (FIG. 4 ), and 81% of the people who judged that the application site was improved also in the subjective evaluation of the subject, whitening the facial skin It was found to be effective in (improve hyperpigmentation).

1-2. Confirm skin tone improvement effect

The effect of improving the skin tone of the functional cosmetic composition prepared in the above Example was confirmed by requesting to the Korea Dermatology Research Institute. Specifically, after 20 subjects were self-applied twice a day for 4 weeks twice a day in the morning and evening, a Chromameter (equipment that converts the color of the surface to digital codes of L, a, and b values using reflected light of two wavelengths) As, L is the brightness, a is a green to red spectrum, b is a blue to yellow spectrum, respectively, using skin tone (skin brightness) improvement effect evaluation (brightness values for the forehead, left cheek and right cheek area of the face L- Value measurement) and use safety evaluation by a dermatologist. The degree of skin tone (L-value) improvement using a chromometer was derived using Equation 2 below, and the safety evaluation by a dermatologist evaluated side effects (erythema, edema, scaling, itching, burning sensation, stiffness, tingling) Abnormal symptoms of the back) were evaluated. The L-value confirmed through the Chromameter was shown in FIG. 6, and the statistical results thereof were shown in Table 9 below.

* p <0.05, ** p <0.01, *** p <0.001

As a result, from 2 weeks after the test, the skin brightness (L-value) increased to a statistically significant level ( p <0.05) compared to before the test ( p <0.05) (FIG. 7 ), and no skin abnormality occurred during the test period. . Therefore, it was confirmed that the cosmetic composition of the present invention has an effect of improving skin tone.

Experimental Example 2. Confirmation of wrinkle improvement effect

2-1. Check the effect of improving wrinkles around the eyes

The effect of improving the eye wrinkles of the functional cosmetic composition prepared in the above example was confirmed by requesting to the Korea Dermatology Research Institute. Specifically, 20 subjects were self-applied twice a day for 4 weeks twice a day in the morning and evening, followed by evaluation by an Antera 3D device (equipment measuring epidermal and dermal conditions using a multi-wavelength LED light source) and dermatologist Use safety evaluation by was performed. The degree of eye wrinkle improvement using Antera 3D equipment was derived from Equation 3 below, and a safety evaluation by a dermatologist evaluated adverse effects such as erythema, edema, swelling, itching, burning sensation, stiffness, tingling, etc. ) Was evaluated for occurrence. The indentation index confirmed through Antera 3D is shown in FIG. 8, and the statistical results thereof are shown in Table 10 below.

* p <0.05, ** p <0.01, *** p <0.001

As a result, from 2 weeks after the test, the eye wrinkle index was reduced to a statistically significant level ( p <0.05) compared to before the test ( p <0.05) (FIG. 9 ), and no skin abnormality occurred during the test period. Therefore, it was found that the cosmetic composition of the present invention has an effect for improving eye wrinkles.

2-2. Confirm the effect of improving skin elasticity and elastic resilience

The effect of improving the skin elasticity and elastic resilience of the functional cosmetic composition prepared in the above example was confirmed by commissioning the Korea Dermatology Research Institute. Specifically, 20 subjects were self-applied twice a day for 4 weeks twice a day in the morning and in the evening, and then cutometer device (2mm probe) (equipment measuring the elasticity and elasticity of the skin using viscoelasticity of the skin using suction cavity) ) And safety evaluation by a dermatologist. The elasticity improvement rate and elasticity recovery rate improvement rate using the cutometer equipment were derived by the following equations 4 and 5, and the safety evaluation by a dermatologist evaluated side effects (erythema, edema, scaling, itching, burning sensation, stiffness, tingling, etc.) Of abnormal symptoms) were evaluated. The cuticle elasticity (R7:Ur/Uf) and elastic resilience confirmed through the cutometer were shown in FIGS. 10 and 11, and their statistical results were shown in Tables 11 and 12, respectively.

* p <0.05, ** p <0.01, *** p <0.001

* p <0.05, ** p <0.01, *** p <0.001

As a result, during the 4-week test period, both the left and right test sites showed an increase in epidermal elasticity and elastic resilience at statistically significant levels (p<0.05) compared to before the test (FIGS. 12 and 13), and skin during the test period. No abnormality occurred. Therefore, it was found that the cosmetic composition of the present invention has an effect of improving the skin elasticity and elasticity restoration.

2-3. Confirm the effect of improving skin density

The effect of improving the skin density of the functional cosmetic composition prepared in the above example was confirmed by commissioning the Korea Dermatology Research Institute. Specifically, after 21 subjects were self-applied twice a day for 4 weeks twice a day in the morning and evening, Ultrasound device (DermaLab Skin, CORTEX TECHNOLOGY) (20MHz ultrasound penetrated up to a depth of 3.37mm from the skin surface to analyze skin structures) Therefore, it was evaluated by the equipment for measuring the cross-section of the skin) and safety evaluation by the dermatologist. The improvement rate of skin density using Ultrasound equipment was derived by the following Equation 6, and the safety evaluation by a dermatologist evaluated the side effects of using the cosmetic composition (erythema, edema, swelling, itching, burning sensation, stiffness, tingling, etc.) The occurrence was evaluated. Skin densities confirmed through Ultrasound are shown in FIG. 14, and their statistical results are shown in Table 13 below.

* p <0.05, ** p <0.01, *** p <0.001

As a result, during the four-week test period, the test site to which the cosmetic composition of the present invention was applied increased skin density to a statistically significant level (p<0.05) compared to before the test (FIG. 15), and skin abnormalities during the test period This did not happen. Therefore, it was found that the cosmetic composition of the present invention has an effect of improving skin density.

Experimental Example 3. Confirmation of moisturizing effect

3-1. Confirm the effect of relieving pruritus by moisturizing and drying the skin

The effect of alleviating the feeling of irritation by moisturizing and drying the skin of the functional cosmetic composition prepared in the above example was confirmed by requesting to the Korea Dermatology Research Institute. Specifically, 20 subjects were self-applied twice a day for 4 weeks twice a day in the morning and evening, and then corneometer device (Courage & Khazaka, Germany) (using the property that the electrostatic capacity of the skin stratum corneum increased in proportion to the moisture content) (Indirectly measuring equipment for moisture content), subjective evaluation by subjects, and safety evaluation by dermatologists. The improvement rate of moisture content using corneometer equipment was derived by the following equation (7), subjective evaluation of subjects was performed based on the following table 14, and safety evaluation by dermatologists was evaluated by side effects (erythema, edema, scale, The occurrence of itching, burning sensation, stiffness, and tingling) was evaluated. The moisture content of the skin (stratum corneum) confirmed through the corneometer was shown in FIG. 16, and their statistical results were shown in Table 15 below. In addition, the subjective evaluation results by the subjects are shown in Fig. 17, and their statistical results are shown in Table 16 below.

* p <0.05, ** p <0.01, *** p <0.001

* p <0.05, ** p <0.01, *** p <0.001

As a result, during the four-week test period, the test site coated with the cosmetic composition of the present invention increased in water content from the stratum corneum to a statistically significant level (p<0.05) from 2 weeks after the test (FIG. 18). The pruritus caused by was alleviated to a statistically significant level (p<0.05) (FIG. 19 ), and no skin abnormalities occurred during the test period. Therefore, it was found that the cosmetic composition of the present invention is effective in alleviating the feeling of irritation by increasing skin moisture content and drying.

3-2. Confirm the effect of improving skin moisture content

The effect of improving the skin moisture content of the functional cosmetic composition prepared in the above example was confirmed by commissioning the Korea Dermatology Research Institute. Specifically, after 20 subjects were self-applied twice a day for 4 weeks twice a day in the morning and evening, evaluation using a corneometer device (Courage & Khazaka, Germany) and safety evaluation by a dermatologist were performed. The improvement rate of moisture content using corneometer equipment was derived from Equation 7 above, and the safety evaluation by dermatologists caused side effects caused by the use of the cosmetic composition (erythema, edema, scaling, itching, burning sensation, stiffness, tingling, etc.) Was evaluated. The water content of the skin (stratum corneum) confirmed through the corneometer was shown in FIG. 20, and their statistical results were shown in Table 17 below.

* p <0.05, ** p <0.01, *** p <0.001

As a result, during the 4-week test period, the test site coated with the cosmetic composition of the present invention increased the moisture content of the stratum corneum to a statistically significant level (p<0.05) from 2 weeks after the test compared to before the test (FIG. 21). No skin abnormalities occurred during this period. Therefore, it was found that the cosmetic composition of the present invention is effective in improving skin moisture content (moisturizing).

3-3. Confirm the effect of improving skin moisture barrier

The effect of improving the skin moisture barrier of the functional cosmetic composition prepared in the above example was confirmed by commissioning the Korea Dermatology Research Institute. Specifically, after subjecting 21 subjects to self-application twice a day for 4 weeks twice a day in the morning and evening, evaluation using Tewameter TM-300 device (Courage & Khazaka, Germany) (equipment for measuring the amount of transdermal moisture loss per unit time) And use safety evaluation by a dermatologist. The TEWL improvement rate using Tewameter TM-300 equipment was derived from Equation 8 below, and the safety evaluation by a dermatologist evaluated side effects caused by the use of the cosmetic composition (erythema, edema, scaling, itching, burning sensation, stiffness, tingling, etc.) ) Was evaluated for occurrence. The amount of transdermal moisture loss confirmed through Tewameter TM-300 is shown in Fig. 22, and their statistical results are shown in Table 18 below.

* p <0.05, ** p <0.01, *** p <0.001

As a result, from 2 weeks after application of the cosmetic composition of the present invention, the amount of transdermal moisture loss decreased to a statistically significant level (p<0.05) compared to before application (FIG. 23), and no skin abnormality occurred during the test period. Therefore, it was found that the cosmetic composition of the present invention has the effect of improving the moisture barrier.

All references, including publications, patent applications, and patents, cited in the present invention, each reference is incorporated herein by reference.

Claims (8)

Oxygen, palmitoyl tripeptide-5, tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate, magnesium chloride, butylene glycol, palmitoyl tripeptide-1, palmitoyltetrapeptide-7, acetylhexapeptide -8, maca root extract, hydrolyzed vegetable protein, sunflower seed oil, white lupine seed extract and hydrolyzed avocado protein as an active ingredient, skin whitening cosmetic composition. According to claim 1, Oxygen, palmitoyl tripeptide-5, tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate, magnesium chloride, butylene glycol, palmitoyl tripeptide-1, palmitoyltetrapeptide -7, containing acetyl hexapeptide-8, maca root extract, hydrolyzed vegetable protein, sunflower seed oil, white lupine seed extract and hydrolyzed avocado protein in 100 parts by weight of the cosmetic composition 0.01 to 10 parts by weight , Cosmetic composition for skin whitening. According to claim 1, Raspberry seed oil / tocopheryl succinate amino propane diol ester, edelweiss callus culture extract, further comprising a Roxempire callus culture filtrate or Lactobacillus milk fermentation filtrate, cosmetic composition for skin whitening. According to claim 3, Raspberry seed oil / tocopheryl succinate amino propane diol ester, Edelweiss callus culture extract, Roxemfire callus culture filtrate or Lactobacillus milk fermentation filtrate 0.001 to 1 part by weight of the cosmetic composition 100 parts by weight Cosmetic composition for skin whitening, which includes as a part. Oxygen, palmitoyl tripeptide-5, tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate, magnesium chloride, butylene glycol, palmitoyl tripeptide-1, palmitoyltetrapeptide-7, acetylhexapeptide -8, containing a maca root extract, hydrolyzed vegetable protein, sunflower seed oil, white lupine seed extract and hydrolyzed avocado protein as active ingredients, cosmetic composition for improving or moisturizing skin wrinkles. According to claim 5, Oxygen, palmitoyl tripeptide-5, tetradecylaminobutyroylvalylaminobutyric ureatrifluoroacetate, magnesium chloride, butylene glycol, palmitoyl tripeptide-1, palmitoyltetrapeptide -7, containing acetyl hexapeptide-8, maca root extract, hydrolyzed vegetable protein, sunflower seed oil, white lupine seed extract and hydrolyzed avocado protein in 100 parts by weight of the cosmetic composition 0.01 to 10 parts by weight , Skin wrinkle improvement or moisturizing cosmetic composition. According to claim 5, Raspberry seed oil / tocopheryl succinate amino propane diol ester, edelweiss callus culture extract, further comprising a rock samfire callus culture filtrate or Lactobacillus milk fermentation filtrate, for improving or moisturizing skin wrinkles Cosmetic composition for. According to claim 7, Raspberry seed oil / tocopheryl succinate amino propane diol ester, edelweiss callus culture extract, rock samfire callus culture filtrate or lactobacillus milk fermentation filtrate 0.001 to 1 part by weight of the cosmetic composition 100 parts by weight Cosmetic composition for improving or moisturizing skin wrinkles, including as a part.

Images