CN114099409A - Soothing and repairing composition and application thereof - Google Patents
Soothing and repairing composition and application thereof Download PDFInfo
- Publication number
- CN114099409A CN114099409A CN202111323661.4A CN202111323661A CN114099409A CN 114099409 A CN114099409 A CN 114099409A CN 202111323661 A CN202111323661 A CN 202111323661A CN 114099409 A CN114099409 A CN 114099409A
- Authority
- CN
- China
- Prior art keywords
- parts
- soothing
- repairing
- extract
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a soothing and repairing composition and application thereof, and relates to the technical field of cosmetics. The soothing and repairing composition provided by the invention comprises the following components in parts by weight: 0.15-2.00 parts of hyaluronic acid elastomer, 0.10-1.00 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.20-3.00 parts of radix ophiopogonis extract, 0.10-3.00 parts of anti-allergy repair peptide, 0.35-1.00 parts of kava extract, 0.10-2.00 parts of tetrandra root extract, 0.10-1.00 parts of lactobacillus/soybean milk fermentation product filtrate and 0.12-0.40 parts of mixture containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate. According to the technical scheme, the soothing and repairing composition is prepared by compounding the components according to a specific ratio, and the components play a synergistic interaction role, so that the composition has allergy prevention, allergy relief and repairing functions, and the skin sensitivity problem can be improved comprehensively.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a soothing and repairing composition and application thereof.
Background
The human skin contains abundant sensory nerve fibers, which allow the central nervous system to detect the condition of the skin at any time and respond to various stimuli, such as physical factor stimuli (climate change, atmospheric pollution, ultraviolet irradiation), chemical factor stimuli (use of poor cosmetics, excessive "acid brushing"), internal factor stimuli (stress, emotion, endocrine disorder), and the like. Sensitive skin is in a sub-health state, and natural barriers of the skin are damaged and self-defense capacity is reduced due to various physical factors, chemical factors and internal psychological and physiological factors, so that external irritants are easy to permeate, sensory nerve signal introduction of the skin is enhanced, tolerance threshold is reduced, the skin is over-reacted to external weak stimulation, immune response of the skin is activated, vessel expansion and inflammatory factor release are caused, subjective symptoms such as burning, stabbing pain, pruritus and tightness of the skin are easy to appear, and objective signs such as erythema, scale and telangiectasia are accompanied or not accompanied.
The existing commercial products only have single solution to anti-allergy and are difficult to simultaneously solve the symptoms of redness, swelling, heat, pain and itching. Most of the commercially available facial mask products have single functions and are difficult to give consideration to both anti-allergy and repairing effects. Most of the face mask products adopt citric acid/sodium citrate as a pH buffer pair, and the citric acid/sodium citrate pH buffer pair has stronger ionicity and has a destructive effect on a specific thickening system when the addition amount is higher; in addition, the facial mask has difficult preservation due to the adsorbability and easy adsorption of microorganisms, and most facial masks in the market solve the problem of preservation by adding preservatives with strong bacteriostatic ability, which brings higher irritation.
Disclosure of Invention
In view of the above problems in the prior art, it is a primary object of the present invention to provide a soothing and repairing composition and its use.
In order to achieve the above purpose, in a first aspect, the present invention provides a soothing and repairing composition, which comprises the following components in parts by weight: 0.15-2.00 parts of hyaluronic acid elastomer, 0.10-1.00 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.20-3.00 parts of radix ophiopogonis extract, 0.10-3.00 parts of anti-allergy repair peptide, 0.35-1.00 parts of kava extract, 0.10-2.00 parts of tetrandra root extract, 0.10-1.00 parts of lactobacillus/soybean milk fermentation product filtrate and 0.12-0.40 parts of mixture containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate.
The hyaluronic acid elastomer, namely a mixture of a sodium hyaluronate cross-linked polymer, 1, 2-pentanediol and water, is an ultra-high molecular weight polymer obtained by cross-linking sodium Hyaluronate (HA) from a natural source, HAs soft and smooth skin feel and high elasticity, can form a long-acting biological protective film on the surface of skin, enhances the skin barrier function, and HAs multiple functions of water locking, water storage, isolation, protection and the like.
The tetrahydro-methyl pyrimidine carboxylic acid exists in halotolerant bacteria as osmotic pressure compensating solute, plays a chemical transmitter-like role in cells, has a stable protection effect on the cells in adverse environment, can also stabilize the structure of enzyme protein in organisms, has the functions of activating skin and resisting aging, can also protect neutrophils, and has an anti-inflammatory effect.
Radix Ophiopogonis contains multiple active ingredients including polysaccharides of radix Ophiopogonis, steroid saponins (ophiopogonin A, B, B ', C, C ' D, D ', etc.), homoisoflavonoids, amino acids, acidic components and volatile oils; the ophiopogonpolysaccharide mainly comprises fructo-oligosaccharide and fructan with the molecular weight of 500-10000, the fructose composition is more than 90%, the ophiopogonpolysaccharide has excellent moisture absorption and retention property, can easily permeate into the deep layer of skin, strengthens the tight connection of the upper layer of the epidermis, keeps the good hydration of the skin, greatly improves the content of transmembrane proteins Claudin-1 and ZO-1 related to the skin tightness, and promotes the epidermis to form a more ordered and compact membrane network structure. The NMF (natural moisturizing factor) content in the skin can be greatly improved, and a lasting moisturizing effect is provided for the skin from inside to outside; the radix Ophiopogonis extract contains specific polysaccharide and saponin components mainly comprising levan, and has multiple effects of moistening skin, resisting inflammation, relieving, activating skin immunity, repairing skin barrier, and resisting photoaging.
The anti-allergy repair peptide is a mixture of palmitoyl tripeptide-1, palmitoyl tripeptide-8, acetyl heptapeptide-4, oligopeptide-1, heptapeptide-6, PPG-5-cetyl polyether-20, glycerol, water, 1, 2-hexanediol and ethylhexyl glycerol. The acetyl heptapeptide-4 can increase skin beneficial bacteria, improve skin immunoreaction and enhance the integrity of physical barriers, thereby improving the self defense system of the skin, enabling the microbial group of the skin to be healthier and enhancing the barrier protection of the skin; oligopeptide-1 can reduce IL-6 secretion induced by TNF-alpha, reduce the influence of inflammation on skin, effectively promote epidermal regeneration, repair skin barrier and remold the biochemical function of skin;
the anti-allergy repair peptide can reduce the release of nerve mediator Substance P Substance, can be combined with MC1-R, can reduce the release of proinflammatory cytokines (IL-1 alpha, IL-8, TNF-alpha), reduce vasodilatation and permeability, reduce edema and erythema, prevent and reduce stimulation, and maintain and restore the normal sensitivity critical of the skin; the anti-allergy repair peptide can regulate and control overreaction of nerve sense, double inhibition of TRPV1+ PAR-2 on C-nerve fiber, effective regulation and control overreaction of nerve sense, and relief of pruritus and swelling and pain symptoms; the anti-allergic repair peptide can activate certain genes involved in the ECM renewal and cell proliferation process, promote skin to synthesize more collagen, reduce inflammatory reaction and glycosylation damage, and reduce the loss rate of the collagen.
Kava extract, namely kava (Piper METHYSTICUM) leaf/root/stem extract, can act on nerve terminals, block neuronal transmission of information by kavain occupying GABAA receptors and inhibiting PGE2 (prostaglandin PEG2 is a known mediator of inflammation, which can cause pain), and inhibit transmission of sensitivity.
The radix Stephaniae Japonicae extract can inhibit proliferation and activation of inflammatory cells such as T lymphocyte, neutrophil and monocyte macrophage, resist free radical injury, inhibit inflammatory mediator release or resist inflammatory mediator effect. The action mechanism is mainly that the calcium ion concentration in neutral granules is reduced, so that the phospholipase A2 activity is inhibited, adenylate cyclase activity is activated, so that the synthesis of CAMP (cyclic adenosine monophosphate) is increased, the release of arachidonic acid is influenced, the release of inflammation mediators such as prostaglandin, leukotriene, thromboxane and platelet activating factor is reduced, the CAMP (cyclic adenosine monophosphate) is increased, the release of lysosomal enzyme and the generation of oxygen free radical are reduced, and the anti-inflammatory effect is achieved. When the foreign antigen substance is combined with the in vivo specific antibody, a large amount of allergic mediators are released by mast cells and basophils to cause local vasodilation, increase of vascular permeability, contraction of organ smooth muscles, enhancement of glandular secretion and the like. The tetrandrine is an active ingredient contained in the tetrandrine extract, can stimulate an adrenal cortex system to cause cortex hyperfunction, plays a role of adrenocortical hormone medicines, has reliable resisting and treating effects on anaphylaxis, and can effectively inhibit acute and chronic inflammation of all parts of the body.
The lactobacillus/soybean milk fermentation product filtrate can keep the diversity and the richness of flora, and can prevent the permanent planting of harmful bacteria by producing antibiotics and competing; it also can maintain skin acidity by producing enzymes to break down free fatty acids.
The composition containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate, namely chlorpheniramine maleate, is a mixture containing hydroxyphenylpropionamide benzoic acid, ascorbyl palmitate, 1, 2-pentanediol and butanediol, can effectively inhibit skin erythema, edema and pruritus caused by histamine, and has antihistaminic, anti-irritation and antipruritic effects.
According to the technical scheme, the soothing and repairing composition is prepared by compounding hyaluronic acid elastomer, tetrahydro-methyl pyrimidine carboxylic acid, an ophiopogon root extract, anti-allergy repairing peptide, a kava extract, a tetrandra root extract, lactobacillus/soybean milk fermentation product filtrate and a mixture containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate according to a specific proportion, and the components play a synergistic effect, so that the composition has anti-allergy, soothing and repairing effects simultaneously, and the skin sensitivity problem can be improved comprehensively.
As a preferred embodiment of the soothing and repairing composition, the soothing and repairing composition comprises the following components in parts by weight: 0.50 part of hyaluronic acid elastomer, 0.50 part of tetrahydromethyl pyrimidine carboxylic acid, 1.00 part of ophiopogon root extract, 1.25 parts of anti-allergy repair peptide, 0.60 part of kava extract, 0.50 part of tetrandra root extract, 0.60 part of lactobacillus/soybean milk fermentation product filtrate and 0.25 part of mixture containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate.
The inventor finds out through a large number of experiments that the components in the composition can play the best anti-allergy, anti-allergy and repairing roles under the proportion.
In a second aspect, the invention also provides the use of a soothing and repairing composition in the preparation of a cosmetic product.
As a preferred embodiment of the use of the soothing and repairing composition of the present invention in the preparation of cosmetics, the cosmetics include at least one of lotions, essences, lotions, creams, cleansing products.
In a third aspect, the invention also provides a soothing and repairing mask, which comprises the following components in parts by weight: 1.40-15.00 parts of a soothing and repairing composition, 0.01-0.05 part of a chelating agent, 0.10-1.00 part of a buffering agent, 0.06-0.18 part of a pH regulator, 0.35-0.50 part of an antioxidant, 2.57-21.60 parts of a humectant, 0.20-0.50 part of a thickening agent, 0.25-3.20 parts of a skin conditioner and 50.00-96.00 parts of water.
As a preferred embodiment of the soothing mask pack of the present invention, the chelating agent is disodium EDTA; the buffer is hydroxyethyl piperazine ethane sulfonic acid; the pH regulator is at least one of aminomethyl propanol, triethanolamine and arginine; the antioxidant is p-hydroxyacetophenone.
The hydroxyethyl piperazine ethane sulfonic acid is a very effective biological buffer, has the function of maintaining the structure and active ingredients of biological enzymes, and can promote the absorption of the active ingredients while lightening the skin color by promoting the natural exfoliation of the horny layer of the skin. In addition, the hydroxyethyl piperazine ethane sulfonic acid can keep a stable pH range for a long time, protect active ingredients from being easily decomposed, and stabilize a product system.
As a preferred embodiment of the soothing mask of the present invention, at least one of the following (a) to (c) is included:
(a) the humectant is at least one of dipropylene glycol, sodium polyglutamate, oligomeric sodium hyaluronate, sodium pyrrolidone carboxylate, 1, 3-propylene glycol and 1, 2-hexanediol;
oligomeric sodium hyaluronate (namely low molecular weight sodium hyaluronate) can rapidly permeate below the stratum corneum of skin, improve the content of hyaluronic acid in the skin, activate the skin, resist aging and have all-round moisturizing effect.
Sodium pyrrolidone carboxylate, Sodium PCA (Sodium PCA), is a moisturizing agent naturally present in human skin, is a natural moisturizing factor present in the skin itself, is a main component in the stratum corneum of the skin, has strong moisturizing properties, and is an amino acid derivative.
(b) The thickening agent is at least one of acrylic acid (ester)/vinyl isodecanoate cross-linked polymer and xanthan gum;
(c) the skin conditioner is at least one of panthenol and dipotassium glycyrrhizinate.
The panthenol is a vitamin B5 derivative, has a small molecular weight, can effectively permeate into horny layer and infiltrate into the horny layer on the surface of the skin, has a strong moisturizing effect, effectively improves rough skin, makes the skin soft and is not sticky; panthenol also has effects of stimulating epithelial cell growth, accelerating wound healing, and repairing tissue wound.
The dipotassium glycyrrhizinate is mainly glycyrrhizin (glycyrrhizic acid) component at root and stem of Glycyrrhrizae radix, has effects of resisting irritation and controlling oil, removing red swelling, diminishing inflammation, healing, effectively preventing sensitive inflammation phenomenon of skin when skin is irritated, and relieving inflammation and tranquilizing caused by sunshine.
As a preferred embodiment of the soothing repairing mask, the soothing repairing mask comprises the following components in parts by weight: 0.15-2.00 parts of hyaluronic acid elastomer, 0.10-1.00 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.20-3.00 parts of radix ophiopogonis extract, 0.1-3.00 parts of anti-allergy repair peptide, 0.35-1.00 parts of kava extract, 0.10-2.00 parts of tetrandra root extract, 0.10-1.00 parts of lactobacillus/soybean milk fermentation product filtrate, 0.12-0.40 part of mixture containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate, 0.01-0.05 part of EDTA disodium, 0.10-1.00 part of hydroxyethyl piperazine ethane sulfonic acid, 0.06-0.18 part of aminomethyl propanol, 0.35-0.50 part of p-hydroxyacetophenone, 1.00-10.00 parts of dipropylene glycol, 0.02-0.20 part of sodium polyglutamate, 0.02-0.20 part of oligomeric sodium hyaluronate, 0.05-0.20 part of sodium pyrrolidone carboxylate, 1.00-10.00 parts of propylene glycol, 0.00-1.00 part of hexanediol, 1.00-0.00 part of 1.00 part of hexanediol, 0.00-1.00 part of 3-2.00 part of hexanediol, 0.10-0.30 part of acrylic acid (ester)/vinyl isodecanoate cross-linked polymer, 0.10-0.20 part of xanthan gum, 0.20-3.00 parts of panthenol, 0.05-0.20 part of dipotassium glycyrrhizinate and 50.00-96.00 parts of water.
According to the technical scheme, the p-hydroxyacetophenone, the 1, 2-hexanediol and the 1, 3-propanediol are matched, and the EDTA disodium is added for synergistic interaction, so that the broad-spectrum preservative effect is achieved at a very low dosage, and the preservative is mild and efficient.
Compared with the prior art, the invention has the beneficial effects that:
according to the technical scheme, the soothing and repairing composition is prepared by compounding the hyaluronic acid elastomer, the tetrahydro-methyl pyrimidine carboxylic acid, the radix ophiopogonis extract, the anti-allergy repairing peptide, the kava extract, the tetrandra root extract, the lactobacillus/soybean milk fermentation product filtrate and the mixture containing the hydroxyphenyl propionamide benzoic acid and the ascorbyl palmitate according to a specific proportion, and the components play a synergistic interaction role, so that the composition has anti-allergy, soothing and repairing functions simultaneously, and the skin sensitivity problem can be improved comprehensively.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
The compositions of the mask product raw materials of examples 1 to 5 and comparative examples 1 to 5 are shown in the following table 1, and the total mass of each example or comparative example is 100 parts by weight.
TABLE 1 raw material composition of examples 1-5 and comparative examples 1-5
The preparation method of the mask products of examples 1 to 5 and comparative examples 1 to 5 includes the steps of:
(1) pre-dispersing xanthan gum, sodium polyglutamate and oligomeric sodium hyaluronate with dipropylene glycol, and uniformly dispersing the acrylic acid (ester)/vinyl isodecanoate crosslinked polymer with cold water and a dispersion disc for later use;
(2) heating p-hydroxyacetophenone and 1, 3-propylene glycol to 65 ℃, dissolving and transparent, adding 1, 2-hexanediol and mixing for later use;
(3) adding water into an emulsifying pot, heating to 80-85 ℃, adding the water obtained in the step (1), adding EDTA disodium and hyaluronic acid elastomer, homogenizing and stirring uniformly, and simultaneously cooling to 65 ℃;
(4) adding panthenol, hydroxyethyl piperazine ethanesulfonic acid and tetrahydro methylpyrimidine carboxylic acid into the step (3), uniformly stirring, and simultaneously cooling to 48 ℃;
(5) sequentially adding aminomethyl propanol, an ophiopogon root extract, anti-allergy repair peptides, a kava extract, a tetrandra root extract, lactobacillus/soybean milk fermentation product filtrate, chlorphenamine maleate, sodium pyrrolidone carboxylate, dipotassium glycyrrhizinate and the step (2) into the step (4), uniformly stirring and filtering to obtain the soothing and repairing facial mask.
Effect example 1
Anti-allergy test (histamine)
The test method of the effect example comprises the following steps: subjects were invited to 70, ages 21 to 42 years, and subjects were randomized into 7 groups of 10 persons each using the same test sample. The subjects in 7 groups were first applied histamine dihydrochloride (3% concentration) to the flexor side of the left arm at 4 x 4cm2On the skin of the area, after the skin has allergy, recording the allergy condition and the appearance time; then, 7 groups of subjects were smeared with the test substances example 1, example 3, example 5, comparative example 1, comparative example 2, comparative example 3, and control group (deionized water) respectively and compared in the test area on the arm flexed side, and the time was recorded immediately after the smearing and the skin condition was observed. The scoring criteria are shown in table 2 below, and the results are shown in tables 3 and 4 below.
TABLE 2 Scoring standards for Effect example 1
TABLE 3 skin erythema response test results
TABLE 4 skin itch response test results
As shown in tables 3 and 4, the skin erythema attenuation and the skin pruritus attenuation of the compositions of the examples 1,3 and 5 are better than those of the comparative examples 1 to 3, and the results show that the components of the soothing and repairing mask composition provided by the invention are synergistic with each other, so that the soothing and repairing mask composition has the remarkable effect of relieving red swelling and pruritus.
Effect example 2
Capsaicin challenge test
Description of the experiment: capsaicin can cause discomfort such as skin prick, redness, fever and the like, 0.01% capsaicin solution is used in the test to cause discomfort, when the prick feeling is more than moderate, the test objects of example 1, example 3, example 5, comparative example 1, comparative example 2, comparative example 3 and a control group (deionized water) are respectively coated on the test area, the redness degree of the test part is observed, and the change of the prick feeling degree is evaluated to judge the relieving effect.
The test method comprises the following steps: subjects were invited to 70, ages 21 to 42 years, and subjects were randomized into 7 groups of 10 persons each using the same test sample. The test area was in the right nasolabial sulcus of the volunteers. Applying 0.01% capsaicin solution to the nasolabial sulcus on the right side of a volunteer, smearing a test object in a test area when the stabbing pain reaches more than moderate, observing the redness degree of the test part, evaluating the change of the stabbing pain degree, recording the stabbing pain degree value of the test area at each stage of sample smearing, wherein the value range is 0-3 points, 0 points are no sensation, 1 points are mild stabbing pain, 2 points are moderate stabbing pain, and 3 points are severe stabbing pain. The results of the experiment are shown in table 5 below.
TABLE 5 Effect example 2 capsaicin challenge test results
As can be seen from Table 5, the results of examples 1,3 and 5 are better than those of comparative examples 1 to 3 in the sense of reducing the tingling sensation, indicating that the components of the soothing and repairing composition of the present invention are synergistic with each other and have a significant effect of relieving the tingling sensation.
Effect example 3
Repair test
In the effect example, the skin moisture loss effect of the product is tested by a skin moisture loss testing method through the influence of cosmetics, the TEWL value of the moisture loss of a subject before and after the product is used is tested, and the change condition of the skin moisture loss before and after the product is used is evaluated, so that the repairing effect of the product on the aspect of improving the skin barrier function is evaluated.
The test method comprises the following steps: subjects were invited to 150 persons, one group of 30 persons, each group using the same test sample. Using the samples of example 2, example 3, example 4, comparative example 4 and comparative example 5, respectively, the subjects applied the product in an amount of 0.50 + -0.05 g, each day, morning and evening, for 4 weeks continuously. Requiring to sit still and relax in the test environment before each collection, and testing TEWL value with a Vapometer percutaneous water loss measuring instrument at 30 min;
△TEWL=(TEWL1-TEWL2)/TEWL1x is 100%; wherein TEWL1: value before product use; TEWL2: number after 4 weeks using product; the larger the delta TEWL is, the larger the reduction amplitude of the percutaneous water loss is, and the better the repair effect is.
Instrument information: a percutaneous water loss measuring instrument Vapometer manufactured by Delfin corporation in Finland is of a model of SWL5201, and the skin water loss condition before and after the product is used is compared through TEWL parameters.
The results of the experiment are shown in table 6 below.
TABLE 6 improvement of the percutaneous Water loss TEWL value
As can be seen from Table 6, the delta TEWL for the examples is much higher than the comparative examples, indicating that the soothing and rejuvenating composition of the present invention is capable of significantly less transdermal water loss of the skin and better improving the skin barrier function.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The soothing and repairing composition is characterized by comprising the following components in parts by weight: 0.15-2.00 parts of hyaluronic acid elastomer, 0.10-1.00 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.20-3.00 parts of radix ophiopogonis extract, 0.10-3.00 parts of anti-allergy repair peptide, 0.35-1.00 parts of kava extract, 0.10-2.00 parts of tetrandra root extract, 0.10-1.00 parts of lactobacillus/soybean milk fermentation product filtrate and 0.12-0.40 parts of mixture containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate.
2. A soothing repair composition according to claim 1 comprising the following components in parts by weight: 0.50 part of hyaluronic acid elastomer, 0.50 part of tetrahydromethyl pyrimidine carboxylic acid, 1.00 part of ophiopogon root extract, 1.25 parts of anti-allergy repair peptide, 0.60 part of kava extract, 0.50 part of tetrandra root extract, 0.60 part of lactobacillus/soybean milk fermentation product filtrate and 0.25 part of mixture containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate.
3. Use of a soothing rejuvenating composition according to claim 1 or 2 for the preparation of a cosmetic product.
4. Use of a soothing and repairing composition as claimed in claim 3 for preparing a cosmetic product, wherein said cosmetic product comprises at least one of a lotion, a serum, a lotion, a cream, a cleanser.
5. The soothing and repairing mask is characterized by comprising the following components in parts by weight: 1.40-15.00 parts of a soothing and repairing composition, 0.01-0.05 part of a chelating agent, 0.10-1.00 part of a buffering agent, 0.06-0.18 part of a pH regulator, 0.35-0.50 part of an antioxidant, 2.57-21.60 parts of a humectant, 0.20-0.50 part of a thickening agent, 0.25-3.20 parts of a skin conditioner and 50.00-96.00 parts of water.
6. A soothing mask as claimed in claim 5, wherein the chelating agent is disodium EDTA; the buffer is hydroxyethyl piperazine ethane sulfonic acid.
7. A soothing mask as claimed in claim 5 wherein the pH modifying agent is at least one of aminomethyl propanol, triethanolamine, arginine.
8. A soothing mask as claimed in claim 5 wherein the antioxidant is p-hydroxyacetophenone.
9. A soothing mask as claimed in claim 5 comprising at least one of the following (a) - (c):
(a) the humectant is at least one of dipropylene glycol, sodium polyglutamate, oligomeric sodium hyaluronate, sodium pyrrolidone carboxylate, 1, 3-propylene glycol and 1, 2-hexanediol;
(b) the thickening agent is at least one of acrylic acid (ester)/vinyl isodecanoate cross-linked polymer and xanthan gum;
(c) the skin conditioner is at least one of panthenol and dipotassium glycyrrhizinate.
10. A soothing and repairing mask as claimed in claim 5, which comprises the following components in parts by weight: 0.15-2.00 parts of hyaluronic acid elastomer, 0.10-1.00 parts of tetrahydro-methyl pyrimidine carboxylic acid, 0.20-3.00 parts of radix ophiopogonis extract, 0.1-3.00 parts of anti-allergy repair peptide, 0.35-1.00 parts of kava extract, 0.10-2.00 parts of tetrandra root extract, 0.10-1.00 parts of lactobacillus/soybean milk fermentation product filtrate, 0.12-0.40 part of mixture containing hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate, 0.01-0.05 part of EDTA disodium, 0.10-1.00 part of hydroxyethyl piperazine ethane sulfonic acid, 0.06-0.18 part of aminomethyl propanol, 0.35-0.50 part of p-hydroxyacetophenone, 1.00-10.00 parts of dipropylene glycol, 0.02-0.20 part of sodium polyglutamate, 0.02-0.20 part of oligomeric sodium hyaluronate, 0.05-0.20 part of sodium pyrrolidone carboxylate, 1.00-10.00 parts of propylene glycol, 0.00-1.00 part of hexanediol, 1.00-0.00 part of 1.00 part of hexanediol, 0.00-1.00 part of 3-2.00 part of hexanediol, 0.10-0.30 part of acrylic acid (ester)/vinyl isodecanoate cross-linked polymer, 0.10-0.20 part of xanthan gum, 0.20-3.00 parts of panthenol, 0.05-0.20 part of dipotassium glycyrrhizinate and 50.00-96.00 parts of water.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111323661.4A CN114099409A (en) | 2021-11-09 | 2021-11-09 | Soothing and repairing composition and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111323661.4A CN114099409A (en) | 2021-11-09 | 2021-11-09 | Soothing and repairing composition and application thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114099409A true CN114099409A (en) | 2022-03-01 |
Family
ID=80378148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202111323661.4A Pending CN114099409A (en) | 2021-11-09 | 2021-11-09 | Soothing and repairing composition and application thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN114099409A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114917178A (en) * | 2022-05-27 | 2022-08-19 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition suitable for dry skin in desert and application thereof |
CN114983865A (en) * | 2022-06-07 | 2022-09-02 | 杭州原极品牌管理有限公司 | Moisturizing and relieving essence composition and preparation method thereof |
CN115040467A (en) * | 2022-07-29 | 2022-09-13 | 哈尔滨敷尔佳科技股份有限公司 | Soothing and anti-allergy composition, preparation method and application thereof |
CN115501127A (en) * | 2022-11-01 | 2022-12-23 | 梅晔生物医药股份有限公司 | Anti-inflammatory and allergy-relieving composition and daily chemical |
CN115624514A (en) * | 2022-10-12 | 2023-01-20 | 杭州时光肌生物科技有限公司 | Preparation method of composite plant extract for improving facial redness |
CN115778843A (en) * | 2022-12-28 | 2023-03-14 | 广州奥利生物科技有限公司 | Repairing cream containing carboxymethyl chitosan and preparation method thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104771331A (en) * | 2015-03-12 | 2015-07-15 | 华熙福瑞达生物医药有限公司 | Hyaluronic acid elastomer and applications thereof |
CN109464373A (en) * | 2018-11-20 | 2019-03-15 | 上海悦目化妆品有限公司 | A kind of antiallergic facial treatment mask |
CN110151650A (en) * | 2019-05-31 | 2019-08-23 | 广东盛美化妆品有限公司 | A kind of Red blood streak dispelling lotion and preparation method thereof of the ingredient of composite reactive containing horse chestnut |
US20200170931A1 (en) * | 2018-08-20 | 2020-06-04 | Andiva Inc. | Soothing cream and manufacturing method thereof |
KR20200068993A (en) * | 2018-12-06 | 2020-06-16 | 자이글주식회사 | Functional cosmetic composition comprising oxygen |
CN112402287A (en) * | 2020-11-09 | 2021-02-26 | 浙江湃肽生物有限公司 | Efficient soothing anti-allergy repair polypeptide combination and application thereof |
-
2021
- 2021-11-09 CN CN202111323661.4A patent/CN114099409A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104771331A (en) * | 2015-03-12 | 2015-07-15 | 华熙福瑞达生物医药有限公司 | Hyaluronic acid elastomer and applications thereof |
US20200170931A1 (en) * | 2018-08-20 | 2020-06-04 | Andiva Inc. | Soothing cream and manufacturing method thereof |
CN109464373A (en) * | 2018-11-20 | 2019-03-15 | 上海悦目化妆品有限公司 | A kind of antiallergic facial treatment mask |
KR20200068993A (en) * | 2018-12-06 | 2020-06-16 | 자이글주식회사 | Functional cosmetic composition comprising oxygen |
CN110151650A (en) * | 2019-05-31 | 2019-08-23 | 广东盛美化妆品有限公司 | A kind of Red blood streak dispelling lotion and preparation method thereof of the ingredient of composite reactive containing horse chestnut |
CN112402287A (en) * | 2020-11-09 | 2021-02-26 | 浙江湃肽生物有限公司 | Efficient soothing anti-allergy repair polypeptide combination and application thereof |
Non-Patent Citations (1)
Title |
---|
济南博锐生物科技有限公司: "博优研专研多效屏障修护霜", Retrieved from the Internet <URL:https://hzpba.nmpa.gov.cn/gccx/chakan.html?prodId=944392760914345984&gb=G> * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114917178A (en) * | 2022-05-27 | 2022-08-19 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition suitable for dry skin in desert and application thereof |
CN114983865A (en) * | 2022-06-07 | 2022-09-02 | 杭州原极品牌管理有限公司 | Moisturizing and relieving essence composition and preparation method thereof |
CN115040467A (en) * | 2022-07-29 | 2022-09-13 | 哈尔滨敷尔佳科技股份有限公司 | Soothing and anti-allergy composition, preparation method and application thereof |
CN115040467B (en) * | 2022-07-29 | 2024-05-03 | 哈尔滨敷尔佳科技股份有限公司 | Composition for relieving and resisting allergy, preparation method and application thereof |
CN115624514A (en) * | 2022-10-12 | 2023-01-20 | 杭州时光肌生物科技有限公司 | Preparation method of composite plant extract for improving facial redness |
CN115501127A (en) * | 2022-11-01 | 2022-12-23 | 梅晔生物医药股份有限公司 | Anti-inflammatory and allergy-relieving composition and daily chemical |
CN115501127B (en) * | 2022-11-01 | 2023-08-18 | 梅晔生物医药股份有限公司 | Anti-inflammatory and allergy-relieving composition and daily chemical product |
CN115778843A (en) * | 2022-12-28 | 2023-03-14 | 广州奥利生物科技有限公司 | Repairing cream containing carboxymethyl chitosan and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN114099409A (en) | Soothing and repairing composition and application thereof | |
CN111407719B (en) | Skin barrier repair compound, face cream and preparation method thereof | |
CN111388405B (en) | Oil-control acne-removing composition | |
CN115317429B (en) | Composition containing recombinant collagen and having repairing and relieving effects, eye cream containing composition, preparation method and application | |
CN114404340B (en) | Plant acne-removing composition and application thereof | |
CN110123729A (en) | A kind of jelly film and preparation method thereof | |
CN109330954B (en) | Whitening skin brightening lotion, preparation method thereof and tyrosinase inhibitor | |
CN111419753A (en) | Preservative-free whitening, freckle-removing and anti-aging ampoule essence and preparation method thereof | |
CN110721148A (en) | Multidirectional pulling and tightening polypeptide essence and preparation method thereof | |
CN114796024B (en) | Bionic sebum composition for skin barrier repair, and preparation method and application thereof | |
CN113368018A (en) | Anti-inflammatory acne-removing composition and preparation method thereof | |
KR20200053815A (en) | A cosmetic composition for improving skin containing a peptide | |
CN114099393B (en) | Composition with tightening and anti-aging effects and preparation method and application thereof | |
CN114099387A (en) | Rose whitening and moisturizing essence emulsion and preparation method thereof | |
CN116672296B (en) | Compound plant extract with soothing and repairing effects, and preparation method and application thereof | |
CN112402308A (en) | Multi-effect relieving moisturizing lotion and preparation method thereof | |
CN116421514A (en) | Acne-removing composition and eye cream for non-irritation of eyes, and preparation method and application of acne-removing composition and eye cream | |
CN112245324B (en) | Cosmetic with moisturizing function and preparation method and application thereof | |
CN108888573B (en) | Soothing and moisturizing cream and preparation method thereof | |
CN113143788A (en) | Multi-effect composition and face cream with moisturizing, repairing and relieving functions | |
CN112716849A (en) | Anti-chap skin cream containing camellia oleifera extract | |
CN115317410B (en) | Fermentation oil for relieving, preserving moisture and enhancing cell viability and preparation method and application thereof | |
CN110755343A (en) | Emulsion for old people and preparation method thereof | |
KR20160020038A (en) | Cosmetic Composition containing Frangipani Oil or Fermented Frangipani Oil | |
KR102657790B1 (en) | Cosmetic composition for improving skin elasticity containing natural extracts |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |