CN114404340B - Plant acne-removing composition and application thereof - Google Patents
Plant acne-removing composition and application thereof Download PDFInfo
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- CN114404340B CN114404340B CN202210230722.0A CN202210230722A CN114404340B CN 114404340 B CN114404340 B CN 114404340B CN 202210230722 A CN202210230722 A CN 202210230722A CN 114404340 B CN114404340 B CN 114404340B
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- acne
- skin
- extract
- salicylic acid
- removing composition
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 92
- 206010000496 acne Diseases 0.000 title claims abstract description 92
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 90
- 239000000284 extract Substances 0.000 claims abstract description 71
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 45
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 45
- 244000086363 Pterocarpus indicus Species 0.000 claims abstract description 26
- 235000009984 Pterocarpus indicus Nutrition 0.000 claims abstract description 26
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 claims abstract description 21
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 claims abstract description 21
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940090813 madecassoside Drugs 0.000 claims abstract description 21
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 37
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 36
- 230000003750 conditioning effect Effects 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- 238000002360 preparation method Methods 0.000 claims description 15
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The application provides a plant acne-removing composition and application thereof, and relates to the technical field of skin care products. The plant acne-removing composition comprises linked salicylic acid, rosewood seed natural extract, boerdosia tree leaf extract, madecassoside and medicinal layer porus extract. The linked salicylic acid plays a role in softening and exfoliating; the rosewood seed extract enables the microecology of the skin to reach an equilibrium point; the boldo leaf extract restores the skin barrier; the hydroxyasiaticoside has effects of relieving inflammation skin, relieving itching, resisting erythema, and reducing skin desquamation; the medicinal Phellinus linteus extract can strengthen and protect skin. The acne muscle is thoroughly repaired from the 6 large effects of exfoliating cutin, controlling oil, removing acnes, resisting inflammation, relieving and repairing, and the healthy state of the acne muscle is recovered from the root.
Description
Technical Field
The application relates to the technical field of skin care products, in particular to a plant acne-removing composition and application thereof.
Background
Dust in the air directly contacts with facial skin, and is easily adsorbed on the skin to block pores. Meanwhile, irregular diet, poor sleep and high pressure are also normalcy of contemporary people, irregular work and rest cause skin metabolic disturbance and cause the breeding of acnes.
"no acne is formed after puberty", which is a common knowledge of the public, but in practice, in addition to puberty acne vulgaris, the public suffers from post-puberty acne, and experts point out that importance is attached to the treatment and care of post-puberty acne. The reason for the long acne is mainly as follows: 1. the action of androgens in vivo increases sebum secretion; 2. the keratinization of the pilosebaceous canal is abnormal, so that the sebum removal is not smooth; 3. propionibacterium acnes proliferates in large amounts; 4. a complex series of inflammatory reactions is secondary, which is the main cause of most adolescent acne vulgaris. In addition to puberty, acne may also occur when the above conditions exist, i.e., post-pubertal acne, which is classified into persistent and delayed post-pubertal acne according to the age of onset. Acne, while not life threatening, severely affects the patient's personal appearance and self-esteem, and even causes psychological illness, resulting in a sub-health condition. The results of the study showed that. Acne is a bad emotion such as low emotion, anxiety, depression, mental stress and the like of a patient, and affects social and psychological problems.
The existing products for removing acnes on the market are various, and with the improvement of the life quality of people, the requirements on the safety, the effectiveness and the experience of the products are higher and higher, so that the effects of removing acnes, such as antibiotics, hormones, acid brushing, laser therapy, traditional Chinese medicine acne removal and the like, are achieved through single effects of inhibiting the propagation of bacteria, stripping horny layers, clearing heat and detoxicating and the like, the effects of treating the symptoms and the root cause are achieved, and the acne muscles are not conditioned from the root cause.
Disclosure of Invention
The invention aims to provide a plant acne-removing composition, and aims to solve the problems that the prior acne-removing method is not capable of treating the symptoms and root causes and is not capable of conditioning the acne muscles from the root.
To achieve the above object, the present application provides a plant acne-removing composition, comprising: linked salicylic acid, rosewood seed extract, boerdossier tree leaf extract, madecassoside and medicinal layer porus extract.
Preferably, the method comprises the following steps in percentage by mass:
0.5% -5% of linked salicylic acid;
3% -30% of rosewood seed extract;
0.5% -5% of a Boerduo tree leaf extract;
0.1% -1% of madecassoside;
0.5% -5% of medicinal layer porus extract;
the balance being water.
Preferably, the method comprises the following steps in percentage by mass:
1% -2% of linked salicylic acid;
5% -25% of rosewood seed extract;
1% -2% of a Boerduo tree leaf extract;
0.2% -0.5% of madecassoside;
1% -3% of a medicinal layer porus extract;
the balance being water.
Preferably, the method further comprises: any one or more of a wetting agent, a thickening agent, and a pH adjuster.
Preferably, the wetting agent comprises: any one or more of propylene glycol, glycerol, butylene glycol, amino acid humectant, and hyaluronic acid.
Preferably, the thickener comprises: xanthan gum, acrylic ester cross-linked polymer, polyacrylate cross-linked polymer-6, hydroxyethyl cellulose, carboxymethyl cellulose, poloxamer.
Preferably, the pH adjuster comprises: any one or more of triethanolamine, sodium hydroxide, citric acid, and sodium citrate.
The application also provides application of the plant acne-removing composition in preparing skin care products.
Preferably, the skin care product comprises any one or more of conditioning water, facial mask, essence, acne-removing cotton piece, facial cleanser or cream.
Compared with the prior art, the beneficial effects of this application include:
the plant acne-removing composition provided by the application consists of linked salicylic acid, rosewood seed natural extract, boerdosia tree leaf extract, madecassoside and medicinal layer porus extract. The traditional salicylic acid is replaced by the linked salicylic acid, so that the irritation of the salicylic acid is reduced, and meanwhile, the salicylic acid stays on the stratum corneum better, and the effect of softening and exfoliating the horns is achieved. The rosewood seed extract can regulate sebum secretion, rebuild acid coat of skin, inhibit proliferation of skin bacteria causing acne, and balance skin microecology by inhibiting 5 alpha reductase activity. The Boldo leaf extract can activate skin self-defense factor-beta defensin, reduce skin redness and restore skin barrier under the condition of not inducing inflammation. Madecassoside has effects of relieving inflammation skin, relieving itching, resisting erythema, and reducing skin desquamation. The medicinal layer porus extract has effects of moisturizing, improving acne pores, tightening skin, strengthening and protecting skin.
Aiming at 4 major factors causing acne, the plant acne-removing composition controls the grease of the acne skin, mildly exfoliates excessive cutin of the skin, reduces bacterial proliferation, enables the skin to achieve microecological balance, and has the effects of diminishing inflammation, relieving and improving pores of the skin after acne removal, so that the acne muscle is thoroughly repaired from exfoliating cutin, controlling oil, removing acne, resisting inflammation, relieving and repairing 6 major effects, and the acne muscle is radically restored to a healthy state.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate certain embodiments of the present application and therefore should not be considered as limiting the scope of the present application.
FIG. 1 is a graph of the results of a reduction in erythema experiment;
fig. 2 is a graph showing the comparison result of the pore improvement experiment.
Detailed Description
The term as used herein:
"prepared from … …" is synonymous with "comprising". The terms "comprising," "including," "having," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, step, method, article, or apparatus.
When an equivalent, concentration, or other value or parameter is expressed as a range, preferred range, or a range bounded by a list of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when ranges of "1 to 5" are disclosed, the described ranges should be construed to include ranges of "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a numerical range is described herein, unless otherwise indicated, the range is intended to include its endpoints and all integers and fractions within the range.
In these examples, the parts and percentages are by mass unless otherwise indicated.
"and/or" is used to indicate that one or both of the illustrated cases may occur, e.g., a and/or B include (a and B) and (a or B).
The application provides a plant acne-removing composition, which comprises the following components: linked salicylic acid, rosewood seed extract, boerdossier tree leaf extract, madecassoside and medicinal layer porus extract.
In the prior art, the effects of removing acnes are achieved by brushing acid (salicylic acid, fruit acid and azelaic acid), softening and exfoliating waste cutin and preventing hair follicle accumulation and keratinization. Brushing acid can make the skin in a new-born state, but the skin is not suitable for use and is easy to become a disfiguring tool. The acidic functional groups have certain irritation, so that the skin becomes sensitive, stabbing, desquamation and reddening. In addition, the acid has low molecular weight and strong penetrability, is difficult to keep stable on the surface layer of the skin with low moisture content, and is quickly transferred to the deep layer of the skin. There is not enough time to stay in the stratum corneum to perform the exfoliating function, but rather, to cause some damage to the deep layers of the skin.
The linked salicylic acid used in the application is formed by linking the acid functional group of salicylic acid and the alcohol functional group of gum arabic according to an equal ratio covalent bond, compared with the traditional salicylic acid, the irritation of the traditional salicylic acid is derived from the acid functional group, and the phenomena of erythema, itching, stinging and the like of skin can be caused. Meanwhile, the molecular weight of the linked salicylic acid is increased, so that the salicylic acid can be well stabilized on the epidermis cutin layer, and the effect of durable exfoliating is achieved. The traditional salicylic acid has small molecular weight, is difficult to keep stability in the epidermis layer, but is quickly transferred to the deep layer of the skin, and does not have enough time for the horny layer to stay for playing a role. The traditional salicylic acid is replaced by the linked salicylic acid, so that the irritation of the salicylic acid is reduced, and meanwhile, the salicylic acid stays on the stratum corneum better, and the effect of softening and exfoliating the horns is achieved. Improves the advantage of salicylic acid, reduces the side effect of easy sensitization, and softens the existing old waste cutin by mildly brushing acid.
The existing acne-removing products basically inhibit the growth of propionibacterium acnes by a sterilization and bacteriostasis principle so as to achieve the acne-removing effect. Propionibacterium acnes is a normal flora of the skin, lodges in hair follicles and sebaceous glands of the skin, and researches show that actinomycetes account for 45.6% of the total bacterial amount on healthy skin, while Propionibacterium acnes is one of the types and plays an important role in skin health.
Propionibacterium acnes is considered to be the most predominant bacterium causing acnes because excessive grease is secreted in the skin, the sebaceous cells are excessively proliferated, the grease is secreted into sebaceous glands and spread in pores, after propionibacterium acnes contacts the grease, triglycerides in the grease are decomposed to form glycerin and fatty acids, the glycerin increases nutrition of bacteria, proliferation of bacteria is caused, and free fatty acids cause keratinization of skin pores, hyperkeratinization, and pore blockage is caused. Bacterial proliferation, pore blockage, and vaccinia formation.
The rosewood seed extract can regulate sebum secretion, inhibit excessive secretion of sebum cells, reduce glycerol and free fatty acid generated by decomposing lipid by lipase, reduce nutrition obtained by acne bacillus, prevent bacteria from propagating in large quantity, inhibit proliferation of skin bacteria causing acne to easily occur, balance skin microecology, rebuild acidic coat of skin, and reduce pore keratinization. The acne removing composition does not aim at killing propionibacteria, and achieves the treatment effect by inhibiting the proliferation of propionibacteria acnes and regulating the balance of skin microecology.
The Boerduo tree leaf extract is derived from Boerduo tree leaves, can activate the skin self-defense factor beta defensin under the condition of not inducing inflammation, can reduce the influence of the outside on the skin, relieve and condition the skin, reduce skin redness and restore skin barrier.
Madecassoside has effects of relieving inflammation skin, relieving itching, resisting erythema, and reducing skin desquamation. The medicinal layer porus extract can moisten and moisten, improve acne pores, tighten skin, strengthen and protect skin.
Aiming at 4 major factors causing acne, the plant acne-removing composition controls the grease of the acne skin, mildly exfoliates excessive cutin of the skin, reduces bacterial proliferation, enables the skin to achieve microecological balance, and has the effects of diminishing inflammation, relieving and improving pores of the skin after acne removal, so that the acne muscle is thoroughly repaired from exfoliating cutin, controlling oil, removing acne, resisting inflammation, relieving and repairing 6 major effects, and the acne muscle is radically restored to a healthy state.
In a preferred embodiment, the method comprises the following steps in percentage by mass:
0.5% -5% of linked salicylic acid;
3% -30% of rosewood seed extract;
0.5% -5% of a Boerduo tree leaf extract;
0.1% -1% of madecassoside;
0.5% -5% of medicinal layer porus extract;
the balance being water.
Preferably, the method comprises the following steps in percentage by mass:
1% -2% of linked salicylic acid;
5% -25% of rosewood seed extract;
1% -2% of a Boerduo tree leaf extract;
0.2% -0.5% of madecassoside;
1% -3% of a medicinal layer porus extract;
the balance being water.
Preferably, the method further comprises: any one or more of a wetting agent, a thickening agent, and a pH adjuster.
Preferably, the wetting agent comprises: any one or more of propylene glycol, glycerol, butylene glycol, amino acid humectant, and hyaluronic acid.
Preferably, the thickener comprises any one or more of xanthan gum, acrylic acid ester cross-linked polymer, polyacrylate cross-linked polymer-6, hydroxyethyl cellulose, carboxymethyl cellulose, and poloxamer.
Preferably, the pH regulator comprises any one or more of triethanolamine, sodium hydroxide, citric acid, and sodium citrate.
The application also provides application of the plant acne-removing composition in preparing skin care products.
Preferably, the skin care product comprises any one or more of conditioning water, facial mask, essence, acne-removing cotton piece, facial cleanser or cream.
Embodiments of the present application will be described in detail below with reference to specific examples, but it will be understood by those skilled in the art that the following examples are only for illustration of the present application and should not be construed as limiting the scope of the present application. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
The rosewood seed extract used in the following examples and comparative examples was purchased from BASF (chinese) limited, and the active ingredient content was 50 wt%; the Boerduo tree leaf extract is purchased from BASF, and the content of effective components is 10 wt%; the medicinal Phellinus linteus (Agaricus campestris) extract is obtained from BASF, and has an active ingredient content of 48 wt%.
Example 1
The formulation of the acne-removing conditioning water of example 1 includes: 1% of linked salicylic acid, 5% of rosewood seed extract, 1% of Boldo leaf extract, 0.2% of madecassoside, 1% of medicinal layer fungus (mushroom) extract, 5% of propylene glycol and 86.8% of water.
The preparation process comprises the following steps:
the components are sequentially added into water and stirred uniformly, so that the acne-removing conditioning water of the embodiment 1 can be obtained.
Example 2
The formulation of the acne-removing conditioning water of example 2 includes: 2% of linked salicylic acid, 5% of rosewood seed extract, 1% of Boldo leaf extract, 0.2% of madecassoside, 1% of medicinal layer fungus (mushroom) extract, 5% of propylene glycol and 85.8% of water. The preparation method is the same as in example 1.
Example 3
The formula of the acne-removing mask of example 3 includes: 1% of linked salicylic acid, 5% of rosewood seed extract, 1% of Boedodes extract, 0.2% of madecassoside, 1% of medicinal layer fungus (mushroom) extract, 5% of propylene glycol, 0.3% of acrylic acid (ester) cross-linked polymer, 0.3% of triethanolamine and 86.2% of water.
The preparation process comprises the following steps:
1. the acrylic acid (ester) cross-linked polymer is firstly soaked and wetted by a proper amount of water for standby.
2. Adding a proper amount of water into a reaction kettle, adding propylene glycol and pre-wetted acrylic acid (ester) cross-linked polymer, and uniformly stirring.
3. Sequentially adding other components of the acne-removing composition into a reaction kettle, and uniformly stirring.
4. Adding triethanolamine into a reaction kettle, wherein the pH value of the tested product reaches 4.0-6.5, and the viscosity reaches 5000-50000.
Example 4
Unlike example 3, the formulation of the acne mask of example 4 includes: 15% rosewood seed extract, 76.2% water, the balance being the same as example 3, and will not be described here again. The preparation method is the same as in example 3.
Example 5
Unlike example 3, the formulation of the acne mask of example 5 includes: 25% rosewood seed extract, 66.2% water, the balance being the same as example 3, and will not be described again here. The preparation method is the same as in example 3.
Example 6
The formulation of the acne-removing essence of example 6 includes: 2% of linked salicylic acid, 10% of rosewood seed extract, 1% of Boldo leaf extract, 0.2% of madecassoside, 1% of Phellinus linteus (Agaricus campestris) extract, 5% of propylene glycol, 0.5% of polyacrylate crosslinked polymer-6,0.1% of xanthan gum and 80.2% of water.
The preparation process comprises the following steps:
1. adding a proper amount of water into a reaction kettle, adding polyacrylate crosslinked polymer-6 into the water, and homogenizing.
2. Adding xanthan gum into a reaction kettle, and uniformly stirring.
3. Sequentially adding propylene glycol and other compositions into a reaction kettle, and uniformly stirring.
Example 7
Unlike example 6, the formulation of the anti-acne essence of example 7 includes: 2% of Boerdossier tree leaf extract, 0.5% of madecassoside, 3% of medicinal layer porus (mushroom) extract, 76.9% of water, and the rest of the materials are the same as in example 6, and the preparation method is the same as in example 6.
Comparative example 1
The formulation of the acne-removing conditioning water of comparative example 1 comprises: 5% of rosewood seed extract, 1% of Boldo leaf extract, 0.2% of madecassoside, 1% of medicinal layer fungus (mushroom) extract, 5% of propylene glycol and 87.8% of water. The preparation method is the same as in example 1.
Comparative example 2
The formulation of the acne-removing conditioning water of comparative example 2 comprises: 1% of traditional salicylic acid, 5% of rosewood seed extract, 1% of Boldo leaf extract, 0.2% of madecassoside, 1% of medicinal layer fungus (mushroom) extract, 5% of propylene glycol and 86.8% of water. The preparation method is the same as in example 1.
Comparative example 3
The formulation of the acne-removing conditioning water of comparative example 3 comprises: 2% of traditional salicylic acid, 5% of rosewood seed extract, 1% of Boldo leaf extract, 0.2% of madecassoside, 1% of medicinal layer fungus (mushroom) extract, 5% of propylene glycol and 85.8% of water. The preparation method is the same as in example 1.
Comparative example 4
Unlike example 3, the acne mask of comparative example 4 was formulated without rosewood seed extract, with water content of 91.2%, and other materials were the same as in example 3, and the preparation method was the same.
Comparative example 5
Unlike example 6, the formulation of the anti-acne essence of comparative example 5 does not contain 1% of the boldo leaf extract, and the rest is the same as in example 6, and the preparation method is the same as in example 6.
Comparative example 6
Unlike example 6, the formulation of the anti-acne essence of comparative example 6 does not contain 0.2% madecassoside, and the rest is the same as in example 6, and the preparation method is the same as in example 6.
Comparative example 7
Unlike example 6, the formulation of the anti-acne essence of comparative example 7 does not contain 1% of the extract of Phellinus linteus (Agaricus campestris), and the rest is the same as in example 6, and the preparation method is the same as in example 6.
Test example 1 penetration of salicylic acid and test of exfoliating Capacity in acne-removing composition
The formulations of the anti-acne conditioning water of examples 1 to 2, and comparative examples 1 to 3 are shown in table 1. Examples 1-2 and comparative examples 1-3 were set up to observe the effect of conventional salicylic acid and linked salicylic acid on skin mainly by measuring the permeability of acne-removing conditioning water, while evaluating whether the effect of linked salicylic acid on exfoliating with conventional salicylic acid was affected or not by testing the exfoliating ability.
Table 1 formulations of anti-acne Conditioning Water of examples 1-2 and comparative examples 1-3
1. Skin penetration test
The skin permeation of the anti-acne conditioning water was measured using a Franz cell device using a spectrophotometer for 24h,48h,72 h. The test results are shown in Table 2.
TABLE 2 skin penetration test results of anti-acne conditioning water
As can be seen from the experimental results in Table 2, the diffusion range of the conventional salicylic acid is wider within 24 hours, and the sustained release range of the linked salicylic acid is more stable after 48 hours. It can be seen that the linked salicylic acid can stay in the epidermis better, thereby increasing the working time in the epidermis to achieve the exfoliating effect.
2. Exfoliating capability test
The exfoliating capacity of the product was evaluated by measuring the rate of skin discoloration. The experimental object: 15 volunteers, one group of three people, use different acne-removing conditioning water respectively, and finally average. The skin was previously treated with dihydroxyacetone and volunteers applied the test article once daily to the hands and after 15 days, the skin was tested for changes in chromaticity. The greater the ITA DEG value, the lighter the skin tone, and conversely the darker. The test results are shown in Table 3.
TABLE 3 results of the Dekeratotic Performance test of anti-acne Conditioning Water
| Numbering device | Comparative example 1 | Comparative example 2 | Comparative example 3 | Example 1 | Example 2 |
| Skin ITA value | 10° | 10° | 12° | 11° | 12° |
| Skin ITA value after 15 days | 15° | 35° | 40° | 34° | 39° |
From the results in Table 3, it can be seen that linked salicylic acid has as good exfoliating effect as conventional salicylic acid and does not have reduced performance due to the linking.
Test example 2 oil control, moisturizing, skin micro-ecological Conditioning test of rosewood seed extract in acne-removing composition
The formulas of the acne-removing masks of examples 3 to 5 and comparative example 4 are shown in Table 4, and the acne-removing masks of examples 3 to 5 and comparative example 4 evaluate the oil control effect of the product without drying the skin mainly by measuring the inhibition efficiency of lipase activity and skin moisture content of the acne-removing mask. Meanwhile, the survival rate of propionibacterium acnes is tested to verify the effect of micro-ecological regulation on skin.
1. Propionibacterium acnes survival and lipase Activity test
The acne mask samples of examples 3-5 and comparative example 4 were added to a culture dish containing 1000 tens of thousands/ml propionibacterium acnes, incubated for 3 days at 37 ℃ without oxygen, and the Optical Density (OD) of the bacteria at 600nm was recorded to determine the growth of the bacteria. The bacterial suspension was then centrifuged (1500 g,5 min) and the lipase substrate (1, 2-dioxolauric acid-glycerol-3- (glutarate 6-methylresorcinol ester) was incubated at 40℃for 1 hour to determine lipase activity.
Table 4 formulation of acne mask of examples 3-5 and comparative example 4
TABLE 5 Propionibacterium acnes survival and lipase Activity test results
As can be seen from the test results in Table 5, the addition of rosewood seed extract did not significantly inhibit the growth of Propionibacterium acnes, but significantly inhibited lipase activity. By inhibiting lipase activity, secretion of oil is inhibited. The secretion of grease is reduced, propionibacterium acnes cannot be greatly propagated, and the normal skin requirement level is maintained, so that the skin reaches the microecological balance state.
2. Skin moisture content test
Skin hydration was tested by testing skin moisture content. The experimental object: the skin moisture content of the skin is tested for 0 days and 28 days by using an SK multifunctional skin tester. And calculating the skin moisture content increase rate MMV, wherein the MMV increase rate is larger than 0, so that the product has moisturizing effect, and the higher the value is, the stronger the moisturizing capability is. The test results are shown in Table 6.
TABLE 6 skin moisture content test results
As can be seen from the test results in Table 6, the addition of rosewood seed extract does not dry the skin due to oil control, and the skin still maintains a certain sense of moisture.
Test example 3 anti-inflammatory, allergy-relieving and pore-improving efficacy test of acne-removing composition
The formulas of the acne-removing essence of examples 6-7 and comparative examples 5-7 are shown in Table 7, the Podoson leaf extract in the acne-removing composition mainly acts to activate the skin self-defense factor, maintain the skin barrier and promote the self-healing capacity of the skin without inducing inflammation, the madecassoside mainly plays a role in relieving and regulating skin redness on inflamed skin, and the medicinal layer porus (mushroom) extract plays a role in astringing pores to restore the skin to a smooth state.
The test is mainly used for observing the effects of the three active substances under different collocations by testing the effects of anti-inflammatory, soothing, repairing and pore improving of the acne-removing essence.
Table 7 formulations of anti-acne essence of examples 6-7 and comparative examples 5-7
1. Evaluation of anti-inflammatory efficacy
The testing method comprises the following steps: the method selects the pro-inflammatory factor TNF-alpha as a detection index, uses LPS to stimulate cultured mouse macrophages, quantitatively detects the expression of the TNF-alpha in the culture supernatant, and examines the inhibition effect of acne-removing essence on the release of inflammatory factors.
Evaluation criteria: by calculating the inhibition rate (%) of TNF-alpha, the inhibition effect of the sample on inflammation was evaluated, and the higher the inhibition rate was, the better the inhibition effect on inflammation was proved.
The test results are shown in Table 8, and the anti-acne essence of examples 6-7 has better inhibition rate on inflammation than that of comparative examples 5-7. The acne-removing composition has the advantages that the composition plays a role in coordination and synergy, and has a good effect on inhibiting inflammation.
TABLE 8 evaluation results of anti-inflammatory efficacy
2. Evaluation of the efficacy of soothing repair
The testing method comprises the following steps: the 25 poxus volunteers with different degrees of erythema on the skin were collected and divided into five groups, and the skin color a (erythema) was measured by using an anti-acne essence daily, in the morning and evening, using a Chromameter for 0 day and 28 days, and the erythema reduction rate was calculated. The experimental results are shown in Table 9, wherein the results of photographing one volunteer on days 0 and 28 are shown in FIG. 1, and the left side of FIG. 1 is the result of day 0 and the right side is the result of day 28.
TABLE 9 evaluation results of relief repair efficacy
From the test results in table 9 and fig. 1, it can be seen that the acne-removing essence has a soothing and repairing effect on skin. Wherein examples 6 to 7 are superior in effect to comparative examples 5 to 7. The acne-removing composition has the function of coordination and synergy.
3. Pore improving efficacy evaluation
The testing method comprises the following steps: 9 volunteers with large oily skin and pores are collected, a test area is determined, acne-removing essence is used in the area every morning and evening, and pore area change is tested for 0 days and 14 days to evaluate the improvement effect of pores. The test results are shown in Table 10, wherein the results of photographing one volunteer on days 0 and 14 are shown in FIG. 2, and the left side of FIG. 2 is the result of day 0 and the right side is the result of day 14.
Table 10 results of evaluation of pore-improving efficacy
As can be seen from the test data in table 10 and fig. 2, the acne-removing essence has a remarkable improvement effect on pores.
In conclusion, the skin care product obtained by the formula of the plant acne removal composition can thoroughly repair the acne muscles from the large effects of exfoliating cutin, controlling oil, removing acnes, resisting inflammation, relieving and repairing 6, and can radically restore the acne muscles to a healthy state.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present application, and not for limiting the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present application.
Furthermore, those skilled in the art will appreciate that while some embodiments herein include some features but not others included in other embodiments, combinations of features of different embodiments are meant to be within the scope of the present application and form different embodiments. For example, in the claims below, any of the claimed embodiments may be used in any combination. The information disclosed in this background section is only for enhancement of understanding of the general background of the application and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
Claims (7)
1. The plant acne-removing composition is characterized by comprising the following components in percentage by mass:
1% -2% of linked salicylic acid;
5% -25% of rosewood seed extract;
1% -2% of a Boerduo tree leaf extract;
0.2% -0.5% of madecassoside;
1% -3% of a medicinal layer porus extract;
the balance being water;
wherein the linked salicylic acid is formed by linking an acidic functional group of salicylic acid and an alcohol functional group of gum arabic in an equal ratio through covalent bonds.
2. The plant acne-removing composition of claim 1, further comprising: any one or more of a wetting agent, a thickening agent, and a pH adjuster.
3. The plant acne-removing composition according to claim 2, wherein the wetting agent comprises: any one or more of propylene glycol, glycerol, butylene glycol, amino acid humectant, and hyaluronic acid.
4. The plant acne-removing composition according to claim 2, wherein the thickener comprises any one or more of xanthan gum, acrylic cross-linked polymer, polyacrylate cross-linked polymer-6, hydroxyethyl cellulose, carboxymethyl cellulose, poloxamer.
5. The plant acne-removing composition according to claim 2, wherein the pH adjuster comprises any one or more of triethanolamine, sodium hydroxide, citric acid, sodium citrate.
6. Use of a plant acne-removing composition according to any one of claims 1 to 5 for the preparation of a skin care product.
7. The use according to claim 6, wherein the skin care product comprises any one or more of conditioning water, mask, essence, anti-acne cotton sheet, facial cleanser or cream.
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|---|---|---|---|---|
| CN109157450A (en) * | 2018-10-16 | 2019-01-08 | 广州科玛生物科技股份有限公司 | A kind of anti-acne essence cream |
| CN109260075A (en) * | 2018-10-16 | 2019-01-25 | 广州科玛生物科技股份有限公司 | A kind of anti-acne opsonic water |
| CN111568834A (en) * | 2020-06-29 | 2020-08-25 | 广州广妆生物科技有限公司 | Pure natural plant acne-removing and acne-removing mark-lightening composition, essence containing pure natural plant acne-removing and acne-lightening composition, and preparation method and application of pure natural plant acne-removing and acne-lightening composition |
| CN112618456A (en) * | 2020-12-31 | 2021-04-09 | 彭氏(惠州)实业发展有限公司 | Oil control convergence set and using method thereof |
| CN112972295A (en) * | 2021-04-12 | 2021-06-18 | 东晟源研究院(广州)有限公司 | Oil-controlling and acne-inhibiting rosewood seed essence |
-
2022
- 2022-03-10 CN CN202210230722.0A patent/CN114404340B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109157450A (en) * | 2018-10-16 | 2019-01-08 | 广州科玛生物科技股份有限公司 | A kind of anti-acne essence cream |
| CN109260075A (en) * | 2018-10-16 | 2019-01-25 | 广州科玛生物科技股份有限公司 | A kind of anti-acne opsonic water |
| CN111568834A (en) * | 2020-06-29 | 2020-08-25 | 广州广妆生物科技有限公司 | Pure natural plant acne-removing and acne-removing mark-lightening composition, essence containing pure natural plant acne-removing and acne-lightening composition, and preparation method and application of pure natural plant acne-removing and acne-lightening composition |
| CN112618456A (en) * | 2020-12-31 | 2021-04-09 | 彭氏(惠州)实业发展有限公司 | Oil control convergence set and using method thereof |
| CN112972295A (en) * | 2021-04-12 | 2021-06-18 | 东晟源研究院(广州)有限公司 | Oil-controlling and acne-inhibiting rosewood seed essence |
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| CN114404340A (en) | 2022-04-29 |
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