CN111494270A - Multi-effect relieving essence composition, multi-effect relieving essence lotion and preparation method of multi-effect relieving essence lotion - Google Patents

Multi-effect relieving essence composition, multi-effect relieving essence lotion and preparation method of multi-effect relieving essence lotion Download PDF

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CN111494270A
CN111494270A CN202010549337.3A CN202010549337A CN111494270A CN 111494270 A CN111494270 A CN 111494270A CN 202010549337 A CN202010549337 A CN 202010549337A CN 111494270 A CN111494270 A CN 111494270A
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林立宇
段红丽
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Guangzhou Pugao Management Consulting Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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    • A61K8/4953Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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    • A61K8/553Phospholipids, e.g. lecithin
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61Q19/00Preparations for care of the skin
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/75Anti-irritant

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Abstract

The invention discloses a multi-effect relieving essence composition, a multi-effect relieving essence lotion and a preparation method thereof.

Description

Multi-effect relieving essence composition, multi-effect relieving essence lotion and preparation method of multi-effect relieving essence lotion
Technical Field
The invention relates to the technical field of daily cosmetics, and in particular relates to a multi-effect relieving essence composition, a multi-effect relieving essence lotion and a preparation method thereof.
Background
Because the face skin of a human body directly contacts with the external environment and is easily damaged by the environment, dust, particles, harmful gas and various bacteria in the air can all cause damage to the skin, and inflammation is caused. At present, environmental pollution is increasingly serious, the face skin is increasingly stimulated by the outside world, and the skin symptoms are easy to repeat. In addition, the increasing pressure of work and life, and the change of diet structure all can cause the allergic symptoms of human skin to be aggravated and frequent. Therefore, health care and maintenance of skin are becoming the focus of people's daily life.
The skin care and maintenance basically depends on the use of skin care products, and the corresponding skin care products can effectively delay the aging of normal skin, improve the tolerance degree of the skin to external stimulation and prevent the occurrence of skin diseases. However, many skin care products on the market have sensitization, often cause skin allergy, and cause allergic symptoms such as itching and redness, so that before the skin care products are used, safe care products are needed to enhance the barrier protection function of the skin and keep the skin in a healthy state.
Disclosure of Invention
The invention aims to provide a multi-effect relieving essence composition aiming at the defects in the prior art. The multi-effect relieving essence composition has good anti-allergy relieving effect, can effectively enhance the barrier protection function of skin, reduces the sensitization to the skin when other skin care cosmetics are used, and protects the health of the skin.
The invention also aims to provide the multi-effect relieving essence. The multi-effect relieving essence is based on the multi-effect relieving essence composition, and has a good multi-effect relieving effect; in addition, the skin care cream has good moisture-keeping and skin-moistening properties, can effectively maintain, nourish and care the skin while enhancing the barrier protection function of the skin, and can better protect the health state of the skin.
Another object of the present invention is to provide a method for preparing the multi-effect soothing essence. According to the method, the preparation process is controlled according to the characteristics of the raw material components in the multi-effect soothing essence lotion, so that the multi-effect soothing essence lotion which is uniform in dispersion, good in stability and excellent in skin feeling can be prepared.
The purpose of the invention is realized by the following technical scheme.
The multi-effect relieving essence composition comprises the following components in parts by weight:
0.05-0.5 part of lecithin, 0.02-0.15 part of aescin, 0.03-0.35 part of β -sitosterol, 0.2-1.0 part of creatine, 0.5-5.0 parts of methylsilanol mannuronate, 1.0-5.0 parts of spilanthol flower extract and 0.05-0.75 part of caffeine.
In a preferred embodiment, the composition comprises the following components in parts by weight:
0.08-0.1 part of lecithin, 0.02-0.03 part of aescin, 0.05-0.06 part of β -sitosterol, 0.3-0.6 part of creatine, 0.5-2.0 parts of methylsilanol mannuronate, 1.0-2.0 parts of spilanthol extract and 0.05-0.25 part of caffeine.
The multi-effect relieving essence comprises the following components in percentage by mass:
0.5-3.0% of emulsifier, 2.0-15.0% of multi-effect relieving essence composition, 3.0-13.0% of emollient, 0.1-0.5% of triethanolamine, 0.2-1.0% of thickener I, 0.05-0.3% of thickener II, 0.1-0.5% of thickener III, 0.15-2.25% of siloxane triol alginate, 0.01-0.12% of disodium EDTA (ethylene diamine tetraacetic acid), 3.0-11.0% of humectant and the balance of water;
the multi-effect relieving essence composition is any one of the multi-effect relieving essence compositions.
In a preferred embodiment, the emulsifier comprises 0.4-2.0% by mass of a combination of bis-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, methoxy PEG/PPG-25/4 polydimethylsiloxane, caprylic/capric triglyceride, and 0.1-1.0% of polyglycerol-3 methyl glucose diisostearate;
in the compound of the double-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, the methoxy PEG/PPG-25/4 polydimethylsiloxane and the caprylic acid/capric acid triglyceride, the mass ratio of the double-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, the methoxy PEG/PPG-25/4 polydimethylsiloxane and the caprylic acid/capric acid triglyceride is 2:1: 1.
In a preferred embodiment, the emollient comprises 1.0-5.0% dimethiconol and 2.0-8.0% diethylhexyl carbonate by weight percent.
In a preferred embodiment, the thickener I comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;
and/or, the thickening agent II comprises gum arabic or xanthan gum;
and/or the thickener III comprises acrylic acid (ester)/C10-30 alcohol acrylate cross-linked polymer.
In a preferred embodiment, the humectant comprises 1.0-4.0% of the seaweed extract, 1.0-6.0% of propylene glycol and 2.0-11.0% of butanediol by mass percentage.
In a preferred embodiment, the anti-allergic agent also comprises 0.5-3.0% by mass.
In a more preferred embodiment, the anti-sensitivity agent comprises a purslane extract.
In a preferred embodiment, the perfume further comprises 0.01-0.2% of essence, 0.1-0.4% of caprylyl glycol, 2.0-8.0% of ethanol and 0.1-0.5% of preservative by mass percentage.
The preparation method of the multi-effect relieving essence comprises the following steps:
s1, mixing the emulsifier, the thickener I and the emollient, heating to 80 +/-2 ℃, preserving heat for 10 minutes, and uniformly stirring;
s2, mixing the humectant, triethanolamine, disodium EDTA, the thickener II, water and lecithin, aescin, β -sitosterol and creatine in the multi-effect soothing essence composition under the condition of low-speed stirring at 40-50 r/min, heating to 85 +/-2 ℃, preserving heat for 10 minutes, and uniformly stirring;
s3, adding the uniformly mixed component S1 into the uniformly mixed component S2 under the high-speed uniform stirring of 3000-3200 r/min, performing uniform stirring for 10 minutes, and cooling;
s4, dissolving and uniformly mixing the thickening agent III, adding the thickening agent III, and continuously homogenizing for 10 minutes;
s5, sequentially adding methylsilanol mannuronate, a spilanthol extract, caffeine and siloxane triol alginate in the multi-effect relieving essence composition, and uniformly stirring; cooling to below 38 ℃, and discharging to obtain the multi-effect relieving essence.
Compared with the prior art, the invention has the following advantages and beneficial effects:
in the multi-effect relieving essence composition, lecithin has a good anti-inflammatory and detoxifying effect and can provide sufficient moisture and oxygen for skin, aescin has multiple effects of anti-inflammation, antioxidation and the like, β -sitosterol has no stimulation to skin and has a remarkable anti-inflammatory function and a wound healing promoting effect, creatine can assist in providing energy for muscles and nerve cells and relieving fatigue, methylsilanol mannuronate has no stimulation to skin and has anti-aging, anti-wrinkle, anti-inflammation, tightening, calming and moisturizing effects, a spilanthus herb extract can relieve muscle tension, reduce wrinkles caused by facial muscle tension or contraction and has an analgesic effect, caffeine has excellent anti-oxidation and anti-inflammatory effects, can reduce fat and increase blood circulation of capillary vessels to nourish skin and prevent skin cancer, and the multi-effect relieving essence composition combines lecithin, aescin, β -sitosterol, methylsilanol mannuronate, a spilanthus herb extract and caffeine according to specific mass parts, has synergistic effects, has anti-inflammatory, anti-oxidation, anti-wrinkle, anti-sedation, soothing, anti-allergy relieving, skin-allergy preventing and skin protecting effects, and other effective skin protection effects when the multi-effect is achieved.
The multi-effect relieving essence disclosed by the invention has a good multi-effect relieving effect based on the multi-effect relieving essence composition, and can effectively guarantee the health of skin; meanwhile, the multi-effect soothing essence lotion is matched with an emollient, a humectant and the like, so that the multi-effect soothing essence lotion also has good moisturizing and skin moistening performance, effectively takes care of skin and better protects the health state of the skin while enhancing the barrier protection function of the skin. In addition, the multi-effect soothing essence is safer and more reliable to use and has better quality guarantee effect due to the compatibility of an anti-allergy agent, a preservative and the like.
According to the preparation method, the corresponding emulsification system is optimized and matched according to the characteristics of the raw material components in the multi-effect soothing essence lotion, the preparation process is accurately controlled, and the multi-effect soothing essence lotion which is uniformly dispersed, has good stability and is excellent in skin feel is prepared.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following specific examples, but the scope and implementation of the present invention are not limited thereto. The present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Also, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The multi-effect relieving essence composition comprises the following components in parts by weight:
0.05-0.5 part of lecithin, 0.02-0.15 part of aescin, 0.03-0.35 part of β -sitosterol, 0.2-1.0 part of creatine, 0.5-5.0 parts of methylsilanol mannuronate, 1.0-5.0 parts of spilanthol flower extract and 0.05-0.75 part of caffeine.
Lecithin is a natural antidote and can degrade toxins produced by a human body to eliminate spots and whelks on the face. Meanwhile, lecithin also has hydrophilicity and has the functions of emulsifying and decomposing grease, so that the lecithin can increase the function of heme, improve blood circulation, improve serum lipid, remove peroxide and provide sufficient moisture and oxygen for skin.
Aescin is an active substance with anti-inflammation and swelling-eliminating effects, has multiple effects of anti-inflammation, anti-oxidation and the like, can play a role in promoting blood circulation, promoting wound healing, resisting edema, resisting inflammation, resisting exudation and protecting blood vessels, and has good anti-oxidation, anti-oxidation and relieving effects.
β -sitosterol is nontoxic, has no irritation to skin, has remarkable anti-inflammatory function, and can be used for treating skin cancer and skin ulcer, β -sitosterol also has excellent antioxidant ability, and can effectively relieve skin aging, and β -sitosterol also has conditioning effect, and can make skin smooth and moist, and treat or delay keratinization of skin.
The physiological function of creatine mainly participates in the conversion of ATP in organisms, and can quickly meet the requirement of human bodies on high energy. In the process of transforming DNA synthesome of skin cells and repairing DNA, creatine plays an important role in quickly supplying energy, so that the skin has good anti-inflammatory property, can effectively prevent and treat skin aging and damage caused by ultraviolet irradiation, promote skin regeneration, prevent skin dryness, relieve pain and itch or other famous discomfort symptoms of sensitive skin and accelerate the healing of the damaged skin.
Methylsilanol mannuronate is synthesized from semi-natural silanols and mannuronic acid. Among them, silanol is an organic derivative of silicon, which is a natural constituent of human connective tissue, and can enhance cell regeneration, connective tissue recombination, cell renewal stimulation and collagen production. The mannuronic acid is extracted from brown algae, and has strong antioxidant function. The methylsilanol mannuronate synthesized by silanol and mannuronic acid has no irritation, can improve the water retention capacity of epidermis, activate the epidermis to be natural and moist but not dry, can remove free radicals and resist saccharification, and has the effects of anti-aging, anti-wrinkle, anti-inflammation, tightening, calming and moisturizing.
Spilanthol extract is considered a natural replacement ingredient for botulinum toxin, and can relieve muscle tension and reduce wrinkles due to facial muscle tension or contraction. In addition, the analgesic amide substance called spilanthol is contained in the composition, so that the composition can easily penetrate the skin, further inhibit the contraction of subcutaneous muscles and achieve the effect of relieving pain.
Caffeine contains high-content polyphenol compounds, is a powerful antioxidant, can effectively promote blood circulation, has excellent antioxidant and anti-inflammatory effects, and can reduce fat, increase blood circulation of capillary, nourish skin, and prevent skin cancer.
In a preferred embodiment, the multi-effect relieving essence composition comprises the following components in parts by weight:
0.08-0.1 part of lecithin, 0.02-0.03 part of aescin, 0.05-0.06 part of β -sitosterol, 0.3-0.6 part of creatine, 0.5-2.0 parts of methylsilanol mannuronate, 1.0-2.0 parts of spilanthol extract and 0.05-0.25 part of caffeine.
The multi-effect relieving essence comprises the following components in percentage by mass:
0.5-3.0% of emulsifier, 2.0-15.0% of multi-effect relieving essence composition, 3.0-13.0% of emollient, 0.1-0.5% of triethanolamine, 0.2-1.0% of thickener I, 0.05-0.3% of thickener II, 0.1-0.5% of thickener III, 0.15-2.25% of siloxane triol alginate, 0.01-0.12% of disodium EDTA (ethylene diamine tetraacetic acid), 3.0-11.0% of humectant and the balance of water;
the multi-effect relieving essence composition is any one of the multi-effect relieving essence compositions.
In a preferred embodiment, the emulsifier comprises 0.4-2.0% by mass of a combination of bis-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, methoxy PEG/PPG-25/4 polydimethylsiloxane, caprylic/capric triglyceride, and 0.1-1.0% of polyglycerol-3 methyl glucose diisostearate;
in the compound of the double-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, the methoxy PEG/PPG-25/4 polydimethylsiloxane and the caprylic acid/capric acid triglyceride, the mass ratio of the double-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, the methoxy PEG/PPG-25/4 polydimethylsiloxane and the caprylic acid/capric acid triglyceride is 2:1: 1.
In a preferred embodiment, the emollient comprises 1.0-5.0% dimethiconol and 2.0-8.0% diethylhexyl carbonate by weight percent.
In a preferred embodiment, the thickener I comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;
and/or, the thickening agent II comprises gum arabic or xanthan gum;
and/or the thickener III comprises acrylic acid (ester)/C10-30 alcohol acrylate cross-linked polymer.
In a preferred embodiment, the humectant comprises 1.0-4.0% of the seaweed extract, 1.0-6.0% of propylene glycol and 2.0-11.0% of butanediol by mass percentage.
In a preferred embodiment, the anti-allergic agent also comprises 0.5-3.0% by mass.
More preferably, the anti-sensitivity agent comprises a purslane extract.
In a preferred embodiment, the perfume further comprises 0.01-0.2% of essence, 0.1-0.4% of caprylyl glycol, 2.0-8.0% of ethanol and 0.1-0.5% of preservative by mass percentage.
More preferably, the preservative comprises phenoxyethanol.
The technical solution of the present invention is described in detail below with reference to specific examples.
Examples 1 to 6
The multi-effect soothing essence lotions of examples 1 to 6 comprise the raw materials in percentage by mass as shown in table 1.
Table 1 raw material composition (mass percentage, total 100%) of the multi-effect soothing essence of examples 1 to 6
Figure BDA0002541936040000041
Figure BDA0002541936040000051
The multi-effect soothing essence lotions of the embodiments 1 to 6 are prepared by the following method, and the specific steps are as follows:
s1, mixing the emulsifier, the thickener I and the emollient, heating to 80 +/-2 ℃, preserving heat for 10 minutes, and uniformly stirring;
s2, mixing the humectant, triethanolamine, disodium EDTA, the thickener II, water and lecithin, aescin, β -sitosterol and creatine in the multi-effect soothing essence composition under the condition of low-speed stirring at 40-50 r/min, heating to 85 +/-2 ℃, preserving heat for 10 minutes, and uniformly stirring;
s3, adding the uniformly mixed component S1 into the uniformly mixed component S2 under the high-speed uniform stirring of 3000-3200 r/min, performing uniform stirring for 10 minutes, and cooling;
s4, dissolving and uniformly mixing the thickening agent III with propylene glycol, adding the mixture, and continuing homogenizing for 10 minutes;
s5, sequentially adding the purslane extract, and the methylsilanol mannuronate and the spilanthol extract in the multi-effect relieving essence composition, dissolving caffeine in the siloxane triol alginate, adding, and uniformly stirring; cooling to 45 deg.C, dissolving essence and phenoxyethanol with ethanol and caprylyl glycol, mixing, adding, and stirring;
s6, cooling to below 38 ℃, and discharging to obtain the multi-effect relieving essence.
Comparative example 1
Compared to example 2, the essence of this comparative example does not contain aescin.
Comparative example 2
Compared to example 2, the essence of this comparative example does not contain lecithin, escin and β -sitosterol.
Comparative example 3
Compared to example 2, the serum of this comparative example does not contain creatine.
Comparative example 4
The essence of this comparative example does not contain methylsilanol mannuronate, compared to example 2.
Comparative example 5
Compared to example 2, the essence of this comparative example does not contain spilanthol extract and caffeine.
According to the preparation method of the embodiment 2, the multi-effect soothing essence of the comparative examples 1-5 is prepared.
1. Stability test
The essence lotions of examples 1 to 6 and comparative examples 1 to 5 were subjected to cold and heat resistance stability tests, and the test results are shown in table 2.
TABLE 2 appearance state and corresponding Performance test results of the essences of examples 1 to 6 and comparative examples 1 to 5
Figure BDA0002541936040000052
Figure BDA0002541936040000061
As shown in table 2, the essence lotions of examples 1 to 6 and comparative examples 1 to 5 have good cold-resistant and heat-resistant physicochemical properties, good stability, and good quality-guaranteeing effect. The essence disclosed by the invention is good in formula stability, good in quality guarantee effect and durable.
2. Irritation test
The test substance: the essences of examples 1 to 6 and comparative examples 1 to 5.
Experimental animals: 33 white rabbits (provided by the department of laboratory animals of Chinese medical university) of common-grade healthy New Zealand species (11 females, 22 males, weight 2.5-3.0 kg) were randomly divided into 11 groups of 3 rabbits (1 female and 2 males) each, and one group of rabbits of each group was used as a unit to correspond to the essence lotions of test examples 1-6 and comparative examples 1-5, respectively.
The experimental method comprises the following steps: a one-time skin irritation test was used.
Before the test, the caps on two sides of the spine of the back of the rabbit are cut off, and the range of the hair-removed part of 4cm by 4cm is taken as a test area.
During testing, 0.5ml of a test object is smeared on a test area on one side of the back of a rabbit, then, gauze and cellophane are used for covering, and then, a medical adhesive plaster is used for fixing; the test area on the other side served as a blank control. The application time is 4h, the skin reaction of the applied part is observed at 1h, 24h, 48h and 72h after the covering is taken out, and the comparison evaluation is carried out with the control part.
Scoring according to skin irritation response scoring standard in cosmetic hygiene Specifications, judging the irritation intensity of the tested substance to the skin according to skin irritation intensity grading standard according to the highest integral mean value of the irritation response at the observation time points of 1h, 24h, 48h and 72h, and the test result is shown in Table 3.
TABLE 3 irritation test results of the essences of examples 1 to 6 and comparative examples 1 to 5
Figure BDA0002541936040000062
Figure BDA0002541936040000071
Note: the stimulation intensity was divided into 3 grades, "-" indicates no stimulation, "+" indicates light stimulation, and "+" indicates medium stimulation.
As can be seen from table 3, the essence lotions of examples 1 to 6 and comparative examples 1 to 5 did not have irritation to the skin. The essence disclosed by the invention is mild and non-irritant to skin, and is comfortable and safe to use.
3. Oxidation resistance test
Test method ABTS free radical stock solution was prepared by mixing 5m L ABTS (7 mmol/L) and 88. mu. L potassium persulfate (140 mmol/L), and standing overnight at room temperature in the dark, and then diluting the ABTS free radical stock solution with distilled water at a ratio of 1:50(v/v) so that the absorbance at 30 ℃ and 734nm wavelength was 0.7. + -. 0.02.
200 mu L essence lotion and 3ml ABTS free radical stock solution are added into a test tube, distilled water is used for replacing the essence lotion for a blank tube, distilled water is used for replacing ABTS free radical stock solution for a control group, after each test sample is placed in the dark for 1h under the room temperature condition, the absorbance is measured at the wavelength of 734nm, 3 parallels are arranged, the result is averaged, and ascorbic acid (VC, 20 mu L) is used as a positive control.
The results of the measurement are calculated by the following formula:
Figure BDA0002541936040000072
the test results are shown in table 4.
TABLE 4 antioxidant test results of the essences of examples 1 to 6 and comparative examples 1 to 5
Figure BDA0002541936040000073
As can be seen from table 4, the essence lotions of examples 1 to 6 have better antioxidant effect than those of comparative examples 1 to 5, and are beneficial to enhancing the anti-aging and anti-wrinkle effects of skin and keeping skin healthy and elastic.
4. Anti-inflammatory assay
The test method comprises the steps of taking Wistar mice (80-100 g of half of a female and a male provided by Kai student science and technology (Shanghai) Co., Ltd.) and randomly grouping 10 mice in each group, wherein each group comprises a blank group (without any treatment), a model group (coated with 100 mu L of liquid paraffin and 50 mu L of an inflammation-causing agent each time) and a test group (coated with essence and 50 mu L of the inflammation-causing agent of examples 1-6 and comparative examples 1-5), uniformly coating corresponding test reagents on the front and back sides of the right ear of the mice respectively, continuously administering for 3 days, and starting to cause inflammation after 24 hours of last administration.
Wherein, the inflammation-causing agent is fully mixed according to the volume ratio of anhydrous ether-croton oil-anhydrous ethanol-distilled water (14.6: 0.4: 4: 1), 100 mu L of the inflammation-causing agent is evenly coated on the front side and the back side of the right auricle of the mouse, and the model is made due to the inflammation.
After 2h of inflammation, the mouse is taken off the neck and killed, two ears are cut along the base line of the auricle, a right ear plate is punched along the same part of the auricle by a stainless steel punch with the diameter of 8mm, the taken-off ear plate is immediately placed on ice, PBS is added, the right ear plate is homogenized in ice bath to prepare an ear swelling tissue homogenate, a homogenate supernatant fluid is prepared by centrifugation at 4 ℃, the protein concentration in the supernatant fluid and the TNF- α, I L-1 β and NO content in the ear tissue are measured according to the operation of a kit instruction, and the measurement results are shown in Table 5.
TABLE 5 anti-inflammatory test results of the essences of examples 1 to 6 and comparative examples 1 to 5
Figure BDA0002541936040000081
Note: compared to model groups, P < 0.01, P < 0.05.
As can be seen from table 5, the essence lotions of examples 1 to 6 have better anti-inflammatory effects than those of comparative examples 1 to 5.
5. Anti-allergy relief effect test
The test substance: the essences of examples 1 to 6 and comparative examples 1 to 5.
Subject: 55 volunteers participating in the experiment were all women of 20-35 years old. 55 volunteers were randomly divided into 11 groups, and the essence lotions of examples 1 to 6 and comparative examples 1 to 5 were tried on each group of volunteers.
The test method comprises the following steps: each subject stimulates the skin on the inner side of the left arm with 6 wt% of capsaicin to cause skin allergy and produce burning sensation, 1ml of corresponding test object is smeared on the part stimulated by the capsaicin according to grouping conditions, the feedback conditions of the subjects are recorded in 10min, 30min and 60min after the test object is smeared, the recovery degree of the skin in different periods is judged according to the burning sensation fed back by the subjects on the tested part, and the test results are shown in table 6.
TABLE 6 results of the soothing test of the essences of examples 1 to 6 and comparative examples 1 to 5
Figure BDA0002541936040000082
Note: the degree of recovery was divided into 4 grades, "I" indicating complete disappearance of the burning sensation, "II" indicating mild burning sensation, "III" indicating moderate burning sensation, and "IV" indicating severe burning sensation.
As can be seen from table 6, the essence lotions of examples 1 to 6 have a faster and more efficient soothing effect than those of comparative examples 1 to 5, and can quickly eliminate the irritation.
6. Test of moisturizing Effect
The test substance: the essence of examples 1 to 6.
Subject: 30 volunteers participating in the experiment are all women of 20-35 years old. 30 volunteers were randomly divided into 6 groups, and the volunteers of each group were tried with the essence lotions of examples 1 to 6 in a group unit.
The test method comprises the following steps: after a subject washes the face with clear water, measuring the skin moisture of the face by using a skin moisture measuring instrument; and then, the corresponding essence lotion of the tested object is used for smearing on the face, and after 2 hours, the moisture of the skin of the face is measured by a skin moisture tester, and the test result is shown in table 7.
Table 7 moisturizing effect test of essence lotions of examples 1 to 6
Figure BDA0002541936040000091
Figure BDA0002541936040000101
As can be seen from table 7, the essence liquids of examples 1 to 6 have a good moisturizing effect. The multifunctional soothing essence disclosed by the invention is based on the multifunctional soothing essence composition, and is compatible with the skin moisturizer, the humectant and the like, so that the multifunctional soothing essence has good moisturizing and skin moistening properties, the barrier protection function of skin is enhanced, the skin is effectively cared, the anti-aging and anti-wrinkle effects of the skin are enhanced, and the health state of the skin is better protected.
The test results in tables 4 to 7 are combined, so that the multi-effect relieving essence composition disclosed by the invention has the advantages that lecithin, aescin, β -sitosterol, creatine, methylsilanol mannuronate, a spilanthol extract and caffeine are compounded according to specific mass parts, the synergistic effect is realized, the multi-effect relieving effects of ageing resistance, wrinkle resistance, inflammation resistance, tightening, sedation, moisture retention and the like are achieved, and the multi-effect relieving essence disclosed by the invention has a good multi-effect relieving effect based on the multi-effect relieving essence composition, can effectively enhance the barrier protection function of skin, reduces the sensitization of other skin care cosmetics to the skin, and protects the health of the skin.
Various technical features of the above embodiments may be combined arbitrarily, and for the sake of brevity, all possible combinations of the technical features of the above embodiments are not described in this specification. However, as long as there is no contradiction between combinations of these technical features, the scope of the present specification should be considered as being described. Furthermore, the above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (10)

1. The multi-effect relieving essence composition is characterized by comprising the following components in parts by mass:
0.05-0.5 part of lecithin, 0.02-0.15 part of aescin, 0.03-0.35 part of β -sitosterol, 0.2-1.0 part of creatine, 0.5-5.0 parts of methylsilanol mannuronate, 1.0-5.0 parts of spilanthol flower extract and 0.05-0.75 part of caffeine.
2. The multi-effect relieving essence composition according to claim 1, which comprises the following components in parts by weight:
0.08-0.1 part of lecithin, 0.02-0.03 part of aescin, 0.05-0.06 part of β -sitosterol, 0.3-0.6 part of creatine, 0.5-2.0 parts of methylsilanol mannuronate, 1.0-2.0 parts of spilanthol extract and 0.05-0.25 part of caffeine.
3. The multi-effect relieving essence is characterized by comprising the following components in percentage by mass:
0.5-3.0% of emulsifier, 2.0-15.0% of multi-effect relieving essence composition, 3.0-13.0% of emollient, 0.1-0.5% of triethanolamine, 0.2-1.0% of thickener I, 0.05-0.3% of thickener II, 0.1-0.5% of thickener III, 0.15-2.25% of siloxane triol alginate, 0.01-0.12% of disodium EDTA (ethylene diamine tetraacetic acid), 3.0-11.0% of humectant and the balance of water;
the multipurpose soothing essence composition is the multipurpose soothing essence composition of claim 1 or 2.
4. The multi-effect soothing essence as claimed in claim 3, wherein the emulsifier comprises 0.4-2.0% by weight of a combination of bis-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, methoxy PEG/PPG-25/4 polydimethylsiloxane, caprylic/capric triglyceride, and 0.1-1.0% by weight of polyglyceryl-3-methylglucdiisostearate;
in the compound of the double-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, the methoxy PEG/PPG-25/4 polydimethylsiloxane and the caprylic acid/capric acid triglyceride, the mass ratio of the double-PEG/PPG-20/5 PEG/PPG-20/5 polydimethylsiloxane, the methoxy PEG/PPG-25/4 polydimethylsiloxane and the caprylic acid/capric acid triglyceride is 2:1: 1.
5. The multi-effect soothing essence according to claim 3, wherein the emollient comprises 1.0-5.0% of dimethiconol and 2.0-8.0% of diethylhexyl carbonate by weight percentage.
6. The multi-effect soothing essence according to claim 3, wherein the thickener I comprises hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;
and/or, the thickening agent II comprises gum arabic or xanthan gum;
and/or the thickener III comprises acrylic acid (ester)/C10-30 alcohol acrylate cross-linked polymer.
7. The multi-effect relaxing essence according to claim 3, wherein the moisturizing agent comprises 1.0-4.0% of seaweed extract, 1.0-6.0% of propylene glycol and 2.0-11.0% of butylene glycol by mass.
8. The multi-effect relaxing essence according to claim 3, further comprising 0.5-3.0% by mass of an anti-allergy agent; the anti-allergic agent comprises a purslane extract.
9. The multi-effect relaxing essence according to any one of claims 3 to 8, further comprising 0.01 to 0.2% of essence, 0.1 to 0.4% of caprylyl glycol, 2.0 to 8.0% of ethanol and 0.1 to 0.5% of preservative by mass.
10. The method for preparing the multi-effect soothing essence of claim 3, which is characterized by comprising the following steps:
s1, mixing the emulsifier, the thickener I and the emollient, heating to 80 +/-2 ℃, preserving heat for 10 minutes, and uniformly stirring;
s2, mixing the humectant, triethanolamine, disodium EDTA, the thickener II, water and lecithin, aescin, β -sitosterol and creatine in the multi-effect soothing essence composition under the condition of low-speed stirring at 40-50 r/min, heating to 85 +/-2 ℃, preserving heat for 10 minutes, and uniformly stirring;
s3, adding the uniformly mixed component S1 into the uniformly mixed component S2 under the high-speed uniform stirring of 3000-3200 r/min, performing uniform stirring for 10 minutes, and cooling;
s4, dissolving and uniformly mixing the thickening agent III, adding the thickening agent III, and continuously homogenizing for 10 minutes;
s5, sequentially adding methylsilanol mannuronate, a spilanthol extract, caffeine and siloxane triol alginate in the multi-effect relieving essence composition, and uniformly stirring; cooling to below 38 ℃, and discharging to obtain the multi-effect relieving essence.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115154355A (en) * 2022-07-19 2022-10-11 广州东森医药科技有限公司 Composition rich in collagen and preparation method and application thereof
CN115300402A (en) * 2022-08-22 2022-11-08 广州药妆日用化工有限公司 Anti-allergy relieving repair emulsion and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115154355A (en) * 2022-07-19 2022-10-11 广州东森医药科技有限公司 Composition rich in collagen and preparation method and application thereof
CN115300402A (en) * 2022-08-22 2022-11-08 广州药妆日用化工有限公司 Anti-allergy relieving repair emulsion and preparation method thereof

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