CN111821211A - Composition with relieving and repairing effects and application thereof - Google Patents
Composition with relieving and repairing effects and application thereof Download PDFInfo
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- CN111821211A CN111821211A CN202010617239.9A CN202010617239A CN111821211A CN 111821211 A CN111821211 A CN 111821211A CN 202010617239 A CN202010617239 A CN 202010617239A CN 111821211 A CN111821211 A CN 111821211A
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- 239000000203 mixture Substances 0.000 title claims abstract description 32
- 230000000694 effects Effects 0.000 title claims abstract description 25
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims abstract description 20
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000003906 humectant Substances 0.000 claims abstract description 11
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 10
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 10
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 10
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229910052802 copper Inorganic materials 0.000 claims abstract description 10
- 239000010949 copper Substances 0.000 claims abstract description 10
- 229960003720 enoxolone Drugs 0.000 claims abstract description 10
- 229940101267 panthenol Drugs 0.000 claims abstract description 10
- 239000011619 pantothenol Substances 0.000 claims abstract description 10
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 10
- WQZGKKKJIJFFOK-UHFFFAOYSA-N hexopyranose Chemical compound OCC1OC(O)C(O)C(O)C1O WQZGKKKJIJFFOK-UHFFFAOYSA-N 0.000 claims abstract description 9
- 230000008439 repair process Effects 0.000 claims abstract description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 15
- 229920002674 hyaluronan Polymers 0.000 claims description 15
- 229960003160 hyaluronic acid Drugs 0.000 claims description 15
- -1 acyl anthranilic acid Chemical compound 0.000 claims description 8
- 239000002537 cosmetic Substances 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 230000003020 moisturizing effect Effects 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000035876 healing Effects 0.000 claims 4
- 208000003251 Pruritus Diseases 0.000 abstract description 5
- 201000004624 Dermatitis Diseases 0.000 abstract description 4
- 230000007803 itching Effects 0.000 abstract description 4
- 238000006243 chemical reaction Methods 0.000 abstract description 3
- 230000008591 skin barrier function Effects 0.000 abstract description 3
- 230000000638 stimulation Effects 0.000 abstract description 3
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 2
- 208000030961 allergic reaction Diseases 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 33
- 230000037307 sensitive skin Effects 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 9
- 239000000686 essence Substances 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000036559 skin health Effects 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 229940085503 testred Drugs 0.000 description 2
- OHVLMTFVQDZYHP-UHFFFAOYSA-N 1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-2-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound N1N=NC=2CN(CCC=21)C(CN1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)=O OHVLMTFVQDZYHP-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- FHKPLLOSJHHKNU-INIZCTEOSA-N [(3S)-3-[8-(1-ethyl-5-methylpyrazol-4-yl)-9-methylpurin-6-yl]oxypyrrolidin-1-yl]-(oxan-4-yl)methanone Chemical compound C(C)N1N=CC(=C1C)C=1N(C2=NC=NC(=C2N=1)O[C@@H]1CN(CC1)C(=O)C1CCOCC1)C FHKPLLOSJHHKNU-INIZCTEOSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/445—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof aromatic, i.e. the carboxylic acid directly linked to the aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a composition with a soothing and repairing effect, which comprises the following components in parts by weight: 1-10 parts of humectant, 0.5-5 parts of panthenol, 0.05-0.5 part of glycyrrhetinic acid, 0.01-0.3 part of tripeptide-1 copper, 0.01-0.2 part of carboxymethyl glucan and 0.005-0.2 part of dihydroavenoyl anthranilic acid. The composition disclosed by the invention can relieve the allergic reaction of the skin, improve the tolerance of the skin, reduce the reaction degree of the skin such as redness, stabbing pain and itching caused by stimulation, repair the problems of skin imbalance, skin barrier function and the like caused by the skin allergy, reduce the moisture loss of the skin and promote the skin to recover the healthy state.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition with a soothing and repairing effect and application thereof.
Background
With the increasing level of consumption, people are increasingly focusing on skin health problems. Nowadays, the air pollution is more and more serious, and the cosmetic types used by people in daily life are more and more, so that the probability of the appearance of sensitive skin and the possibility of skin irritation are increased under the influence of a series of factors.
Sensitive Skin (SS) refers to a high-response state of skin under physiological or pathological conditions, mainly occurs in the face, and clinically, it is characterized by burning, stabbing pain, itching and tense feeling when it is stimulated by physical, chemical and mental factors.
At present, most of products for solving the problem of facial sensitivity rely on moisturizing ingredients to relieve the skin sensitivity symptoms, although the moisture content of the skin can be increased in a short time, the products cannot effectively relieve the skin allergy symptoms such as burning, itching and redness, and cannot repair the skin, and some products even contain hormone ingredients, so that the skin health is not facilitated.
Disclosure of Invention
Based on the above, in order to solve the disadvantages and shortcomings of the prior art, the present invention aims to provide a composition with a soothing and repairing effect and application thereof.
In order to realize the purpose, the technical scheme adopted by the invention is as follows:
the composition with the effect of relieving and repairing comprises the following components in parts by weight: 1-10 parts of humectant, 0.5-5 parts of panthenol, 0.05-0.5 part of glycyrrhetinic acid, 0.01-0.3 part of tripeptide-1 copper, 0.01-0.2 part of carboxymethyl glucan and 0.005-0.2 part of dihydroavenoyl anthranilic acid.
The composition prepared by adopting the specific components and the proportion can relieve the anaphylactic reaction of skin, improve the tolerance of the skin, reduce the reaction degree of the skin such as redness, stabbing pain and pruritus caused by stimulation, repair the problems of skin unbalance, skin barrier function and the like caused by the skin allergy, reduce the water loss of the skin and promote the skin to recover the healthy state.
Preferably, the composition with the effect of relieving and repairing comprises the following components in parts by weight: 4-10 parts of humectant, 2-5 parts of panthenol, 0.1-0.5 part of glycyrrhetinic acid, 0.05-0.3 part of tripeptide-1 copper, 0.1-0.2 part of carboxymethyl glucan and 0.05-0.2 part of dihydroaveoyl anthranilic acid. The composition prepared by the formula can play a role in relieving allergic skin in a short time and promote the skin to recover a healthy state.
More preferably, the composition with the effect of relieving and repairing comprises the following components in parts by weight: 6 parts of humectant, 3.5 parts of panthenol, 0.3 part of glycyrrhetinic acid, 0.15 part of tripeptide-1 copper, 0.12 part of carboxymethyl glucan and 0.1 part of dihydrooat acyl anthranilic acid. The composition prepared by the formula can not only play a role in relieving allergic skin in a short time, but also has a good effect, and the cost is controlled within a reasonable range.
Preferably, the humectant consists of hyaluronic acid, acetylated hyaluronic acid and polyethylene glycol-32 according to the mass ratio of (1.2-3.6) to (0.3-1.5) to (1-5). Preferably, the hyaluronic acid consists of hyaluronic acid with molecular weights of 100-150 million Da, 20-40 million Da and 3-5 million Da respectively according to the mass ratio of (0.5-1): (0.5-2): 0.2-0.6. Preferably, the acetylated hyaluronic acid has a molecular weight of between 3 and 5 million Da. Preferably, the polyethylene glycol-32 has a molecular weight of 1450.
In the humectant, the moisture-retaining components with small molecular weight and medium molecular weight can rapidly permeate into the horny layers with different depths, so as to improve the water content of the horny layers. The high molecular weight moisture keeping component can stay on the surface of the skin to form a semi-closed protective film, so that the percutaneous water loss rate is reduced, and the stratum corneum and the corium layer of the skin are kept in a moist state. The addition of the polyethylene glycol can enable the formed protective film to be more compact, thereby enhancing the protective capability of the protective film, further reducing the percutaneous water loss rate and improving the wettability of the stratum corneum and the corium layer of the skin.
The invention also provides an application of the composition with the effect of relieving and repairing, in particular to an application in cosmetics.
The invention also provides a cosmetic with the effect of relieving and repairing, which contains the composition with the effect of relieving and repairing.
Preferably, the cosmetic further comprises the following components: butylene glycol, glycerin, and carbomer. These ingredients can further reduce the loss of moisture from the skin and increase the moisture content of the skin.
Has the advantages that: the composition disclosed by the invention can relieve the allergic reaction of the skin, improve the tolerance of the skin, reduce the reaction degree of the skin such as redness, stabbing pain and itching caused by stimulation, repair the problems of skin imbalance, skin barrier function and the like caused by the skin allergy, reduce the moisture loss of the skin and promote the skin to recover the healthy state.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention is further illustrated by the following examples. It is apparent that the following examples are only a part of the embodiments of the present invention, and not all of them. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention. The raw materials used in the examples are all commercially available unless otherwise specified.
Examples 1 to 4:
examples 1 to 4 provide essence with soothing and repairing effects, and the weight percentage composition formula of the essence is shown in table 1.
The humectant consists of hyaluronic acid, acetylated hyaluronic acid and polyethylene glycol-32 in a mass ratio of 2.5:1:3, the hyaluronic acid consists of hyaluronic acid with molecular weights of 100-150 ten thousand Da, 20-40 ten thousand Da and 3-5 ten thousand Da respectively in a mass ratio of 1:1:0.4, the molecular weight of the acetylated hyaluronic acid is 3-5 ten thousand Da, and the molecular weight of the polyethylene glycol-32 is 1450.
The preservative comprises the following components in percentage by weight: 90% phenoxyethanol and 10% ethylhexyl glycerol.
The preparation method of the essence of the embodiments 1 to 4 comprises the following steps: dissolving triethanolamine (pH regulator) with appropriate amount of deionized water; adding the balance of deionized water, carbomer, butanediol, glycerol and preservative into a pot, heating to 80 ℃ (or 80-85 ℃), stirring at constant temperature for 20min, then cooling to 60 ℃, adding the prepared triethanolamine solution, stirring for 10min, cooling to 40 ℃, then adding humectant, panthenol, glycyrrhetinic acid, tripeptide-1 copper, carboxymethyl glucan and dihydroavenoyl anthranilic acid, and stirring uniformly to obtain the essence.
Comparative examples 1 to 4:
comparative examples 1 to 4 provide essence solutions, wherein the weight percentage formula is shown in table 1, and the preparation method refers to the examples.
TABLE 1
The test effect is as follows:
subjects with sensitive skin were selected by self-assessment questionnaires.
1. Fill-in skin analysis questionnaire
TABLE 2
The relevant questions in Table 2 were scored according to the subjects (from none to severe, 0-5 points, respectively), and the judgment of sensitive skin was made by performing statistical scores according to the following criteria.
The score is 46-80, belonging to the severe sensitive skin;
the score is 36-45, which belongs to moderate sensitive skin;
the score is 26-35, which belongs to mild sensitive skin;
the score is 15-25, and the skin is insensitive skin or tolerant skin.
In conclusion, the skin with the score of 26-80 belongs to sensitive skin; skin with tolerance of 15-25 points; self-assessment questionnaire-related questions were scored as in table 2 above.
2. Sensitive muscle subjects were selected according to the above method, 10 persons in each group, 8 groups in total, with no significant difference between groups. Before using the test object, carrying out image acquisition on facial skin of the test object by using a VISIA image analysis system, and analyzing a red area image of the skin; the test subject was used 30 minutes later and then subjected to more than one data test, each day of morning and evening, and then continuously used for 7 days and then subjected to more than one data test.
The test substances are the essences of examples 1 to 4 and comparative examples 1 to 4, respectively.
The effect indexes are as follows: the red area of the red area graph has the average difference delta of the feature counts of the red area, and the higher delta is the more obvious improvement of the skin sensitivity.
The results of Δ ═ number of people (after-test red region feature count-before-test red region feature count) are shown in table 3.
TABLE 3
| Sample (I) | Average difference of feature count delta (30min) | Average difference of feature count Δ (day 7) |
| Example 1 | 6 | 18 |
| Example 2 | 15 | 25 |
| Example 3 | 21 | 36 |
| Example 4 | 22 | 39 |
| Comparative example 1 | 5 | 11 |
| Comparative example 2 | 8 | 15 |
| Comparative example 3 | 6 | 16 |
| Comparative example 4 | -2 | 3 |
And (4) analyzing results: as can be seen from Table 3, in all the test groups, comparative example 4 had little improvement effect on sensitive skin due to the absence of the composition of the present invention (i.e., moisturizer, panthenol, glycyrrhetinic acid, tripeptide-1 copper, carboxymethyl dextran, and dihydroavenoanthranilic acid), thus demonstrating that the composition of the present invention is an effective ingredient for soothing and restoring effects. Secondly, the effect of the essence of examples 1 to 4 on improving sensitive skin is obviously better than that of comparative examples 1 to 3, so that the composition containing the moisturizing agent, panthenol, glycyrrhetinic acid, tripeptide-1 copper, carboxymethyl glucan and dihydroavenoyl anthranilic acid can play a good role in soothing and repairing, and the components of the composition generate a synergistic effect. Furthermore, in the essences of examples 1 to 4, the content of each component of the composition is increased by times, but the effect is not so, but the contents are gradually and remarkably increased from examples 1 and 2 to 3, but the contents are not remarkably increased from examples 3 to 4 but are gradually and smoothly reduced, but the cost of example 4 is remarkably higher than that of example 3, so that the formula of example 3 is used as the optimal formula in the invention.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The composition with the effect of relieving and repairing is characterized by comprising the following components in parts by weight: 1-10 parts of humectant, 0.5-5 parts of panthenol, 0.05-0.5 part of glycyrrhetinic acid, 0.01-0.3 part of tripeptide-1 copper, 0.01-0.2 part of carboxymethyl glucan and 0.005-0.2 part of dihydroavenoyl anthranilic acid.
2. A soothing and healing composition as claimed in claim 1, wherein said soothing and healing composition comprises the following components in parts by weight: 4-10 parts of humectant, 2-5 parts of panthenol, 0.1-0.5 part of glycyrrhetinic acid, 0.05-0.3 part of tripeptide-1 copper, 0.1-0.2 part of carboxymethyl glucan and 0.05-0.2 part of dihydroaveoyl anthranilic acid.
3. A soothing and healing composition as claimed in claim 1, wherein said soothing and healing composition comprises the following components in parts by weight: 6 parts of humectant, 3.5 parts of panthenol, 0.3 part of glycyrrhetinic acid, 0.15 part of tripeptide-1 copper, 0.12 part of carboxymethyl glucan and 0.1 part of dihydrooat acyl anthranilic acid.
4. The composition with soothing and repairing effects as claimed in claim 1, wherein the moisturizing agent is composed of hyaluronic acid, acetylated hyaluronic acid and polyethylene glycol-32 in a mass ratio of (1.2-3.6) to (0.3-1.5) to (1-5).
5. A composition with soothing repair effects as claimed in claim 4, wherein the hyaluronic acid is composed of hyaluronic acid having molecular weights of 100 to 150 ten thousand Da, 20 to 40 ten thousand Da and 3 to 5 ten thousand Da, respectively, in a mass ratio of (0.5 to 1): (0.5 to 2): (0.2 to 0.6).
6. A composition having soothing repair as claimed in claim 4 wherein the acetylated hyaluronic acid has a molecular weight of 3 to 5 ten thousand Da.
7. A composition having soothing repair efficacy according to claim 4, wherein said polyethylene glycol-32 has a molecular weight of 1450.
8. Use of a soothing and repairing composition as claimed in any one of claims 1 to 7 in cosmetics.
9. A cosmetic with soothing and repairing effects, which comprises the composition with soothing and repairing effects as claimed in any one of claims 1 to 7.
10. A soothing restorative cosmetic as claimed in claim 9, further comprising the following components: butylene glycol, glycerin, and carbomer.
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| CN113506601A (en) * | 2021-07-13 | 2021-10-15 | 北京美医医学技术研究院有限公司 | Big data-based skin tolerance analysis system |
| CN114869804A (en) * | 2021-04-19 | 2022-08-09 | 苏州宝丽洁日化有限公司 | Cosmetic composition, preparation method thereof and wet tissue suitable for sensitive skin |
| CN115192500A (en) * | 2021-09-28 | 2022-10-18 | 杭州科腾生物制品有限公司 | Composition with skin anti-allergy repair and skin regeneration functions and preparation method thereof |
| CN115517997A (en) * | 2022-09-27 | 2022-12-27 | 浙江湃肽生物股份有限公司 | Cosmetic composition and preparation method and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114869804A (en) * | 2021-04-19 | 2022-08-09 | 苏州宝丽洁日化有限公司 | Cosmetic composition, preparation method thereof and wet tissue suitable for sensitive skin |
| CN113506601A (en) * | 2021-07-13 | 2021-10-15 | 北京美医医学技术研究院有限公司 | Big data-based skin tolerance analysis system |
| CN113506601B (en) * | 2021-07-13 | 2024-01-16 | 北京美医医学技术研究院有限公司 | Skin tolerance analysis system based on big data |
| CN115192500A (en) * | 2021-09-28 | 2022-10-18 | 杭州科腾生物制品有限公司 | Composition with skin anti-allergy repair and skin regeneration functions and preparation method thereof |
| CN115517997A (en) * | 2022-09-27 | 2022-12-27 | 浙江湃肽生物股份有限公司 | Cosmetic composition and preparation method and application thereof |
| CN115517997B (en) * | 2022-09-27 | 2024-01-23 | 浙江湃肽生物股份有限公司 | Cosmetic composition, and preparation method and application thereof |
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Application publication date: 20201027 |