CN111067828A

CN111067828A - Cosmetic composition for anti-allergy repair

Info

Publication number: CN111067828A
Application number: CN201911308073.6A
Authority: CN
Inventors: 张彩华; 陈秋娟; 梁燕坤; 游少美; 李碧榆; 郭楚欣; 苏艳艳
Original assignee: Foshan Auzimei Biotechnology Co ltd
Current assignee: Foshan Auzimei Biotechnology Co ltd
Priority date: 2019-12-16
Filing date: 2019-12-16
Publication date: 2020-04-28

Abstract

The invention relates to the technical field of skin care, and particularly discloses a cosmetic composition for anti-allergy repair, which comprises the following components in percentage by mass: 0.2-4.0% of water-locking magnet; 0.2-3.0% of skin physiological lipid complex; 0.2-4.0% of nano-coated anti-allergy compound; the nano-encapsulated anti-allergy compound effectively relieves the immune inflammatory reaction of the skin, improves discomfort caused by damage of the skin barrier and inflammation, balances the skin microbial barrier by combining the water-locking magnet, endogenously promotes the generation of NMF and hyaluronic acid, and exogenously supplements the physiological lipid complex of the skin, thereby realizing the repair of the skin double barriers from inside to outside.

Description

Cosmetic composition for anti-allergy repair

Technical Field

The invention relates to the technical field of skin care, in particular to a cosmetic composition for anti-allergy repair.

Background

The sensitive skin refers to a high-response state of the skin under physiological or pathological conditions, mainly occurs on the face, and is characterized in that the skin is easy to have subjective symptoms such as burning, stabbing pain, pruritus and tightness when being stimulated by physical, chemical, mental and other factors, and is sometimes accompanied by objective signs such as erythema, scale, telangiectasia and the like. The development of sensitive skin is currently considered to be a complex process involving the skin barrier-neurovascular-immune inflammation. Therefore, the approaches of anti-allergy repair cosmetics on the market at present mainly focus on three major aspects: 1) repairing the skin barrier; 2) modulating the TRPV1 receptor; 3) up-regulate the expression of immune and inflammatory factors.

However, the existing anti-allergy repair products have the following defects:

1) some anti-allergy repair products only focus on repairing skin barriers, but ignore the influencing factors of TRPV1 receptor, immune and inflammatory factors;

2) in targeting skin barrier repair, repair is made only to the stratum corneum, ignoring the micro-ecological barrier located above it, i.e. the microbial flora symbiotic with the skin. The skin microecology is composed of a plurality of microbial flora of different habitats of the skin, the microbial flora colonized under the normal skin state and the skin form a good symbiotic relationship, keratinocytes can specifically recognize symbiotic flora through PRR, the symbiotic flora inhibits invasion of external harmful flora through self-generated AMPs, and simultaneously, the keratinocyte can be regulated, controlled and induced to secrete AMPs for inhibiting and killing harmful transient flora, so that a microbial barrier at the outermost periphery of the skin is formed, and the function of an immune barrier is exerted. However, once the barrier is disordered, the flora is disordered, the skin microbial barrier is unbalanced, and various skin problems can be induced mainly by excessive reproduction of harmful bacteria, wherein the most common phenomenon is the occurrence of sensitive skin;

3) skin sensitivity is a complex reaction involving nerve vessels in the dermis, active ingredients must penetrate the epidermal barrier to reach each target point of the dermis to play a role, and the existing repair anti-sensitivity products are usually added with penetration enhancers capable of changing the permeability of the skin, such as propylene glycol, azone, dimethyl sulfoxide, dimethyl acetamide and the like, so that although the penetration of the active ingredients is facilitated, the skin irritation is easily caused by changing the permeability of the skin, and the secondary damage of the sensitive skin is caused.

The existing anti-allergy repair products have poor using effect, irritation and insufficient safety, so that a product which can effectively repair sensitive skin, has mild and safe effect is urgently needed.

Disclosure of Invention

The invention aims to provide a cosmetic composition for anti-allergy repair, which has good anti-allergy repair effect and safe effect, aiming at the existing technical situation.

In order to achieve the purpose, the invention adopts the following technical scheme:

a cosmetic composition for anti-allergy restoration comprises the following components in percentage by mass:

0.2-4.0% of water-locking magnet;

0.2-3.0% of skin physiological lipid complex;

0.2-4.0% of nano-coated anti-allergy compound;

the balance of common matrix and/or water of the cosmetic external preparation;

the skin physiological lipid complex comprises ceramide 3, cholesterol, phytosphingosine and free fatty acid;

the nanometer coated anti-allergy compound comprises a salvia extract, a stevia rebaudiana leaf/stem extract, a gardenia fruit extract, silymarin and a cannabis leaf extract.

The water can be deionized water, distilled water and purified water;

the common matrix of the cosmetic external preparation can be common matrix of external preparation which can be applied to cosmetics and is acceptable in cosmetology, such as solvent, solubilizer, preservative, antioxidant, pH regulator, penetration enhancer, liposome, humectant, thickener, chelating agent, skin feeling regulator, surfactant, emulsifier, propellant, essence, pigment and one or more of other functional additives.

According to the invention, firstly, the immune inflammatory reaction of the skin is relieved by wrapping the anti-allergy compound with the nano-material, the discomfort caused by the damage of the skin barrier and the inflammation is improved, and then, through the repair of the two layers of barriers (namely, the repair of the microbial barrier by the water-locking magnet and the repair of the physical barrier by the physiological lipid compound of the skin), various components are reasonably combined and matched for sharing, so that the effects of quick and slow effect and long-acting repair are achieved, the component action is mild, the use is safe, and the secondary damage to the sensitive skin in the use process is effectively avoided.

The composition of skin stratum corneum lipids is known to be: 50% ceramide, 25% cholesterol, 15% free fatty acid, and a part of phytosphingosine, sphingosine, and dihydrosphingosine. When the stratum corneum is damaged by skin aging or external stimuli, the ceramide content in the skin is reduced, and the barrier function of the stratum corneum is disturbed, thereby causing a series of skin problems. The invention adopts a skin physiological lipid complex to effectively repair physical barrier damage, and as a preferred embodiment of the invention, the skin physiological lipid complex adopts a natural lipid proportion similar to that found in human skin, and the skin physiological lipid complex comprises the following components in percentage by mass: 33.5% of ceramide; c8-12 acid triglyceride 0.3-3.0%; 0.5 to 5.0 percent of cholesterol; hydrogenated lecithin 0.2-2.0%; phytosphingosine 1.5%; 0.5 to 5.0 percent of stearic acid; 0.2 to 2.0 percent of oleic acid; 0.2-2.0% of lactic acid and the balance of water, wherein the free fatty acid comprises oleic acid and lactic acid.

The skin stratum corneum barrier function is mainly provided by stratum corneum intercellular lipid, wherein ceramide plays an important role in the stratum corneum intercellular lipid, and the ceramide adopted by the invention is fermented by yeast, so that the skin-friendly property is better.

The component structure of the skin physiological lipid complex simulates intercellular lipid of stratum corneum of skin, has good skin affinity with the skin, is easy to be absorbed and permeated by the skin, and repairs the damaged intercellular lipid by exogenous to maintain the water balance of the skin so as to achieve the effect of repairing the stratum corneum barrier.

In addition, the invention also combines the water-locking magnet to repair the skin microbial barrier damage and endogenously promote the generation of NMF and hyaluronic acid, and preferably, the water-locking magnet is a polysaccharide aqueous solution containing 95% of micromolecular polysaccharide.

The water-locking magnet is a commercially available product, has the Latin name of SACCHARIDE ISOMERATE, is a micromolecular polysaccharide prebiotic, contains micromolecular polysaccharide up to 95%, can be eaten by saprophytic bacteria (beneficial bacteria) of the skin, is not utilized by pathogenic bacteria of the skin, and competitively inhibits the growth of the pathogenic bacteria by activating the growth of the saprophytic bacteria on the skin, so that the microecological balance of the skin is maintained, and a healthy peripheral microbial barrier is constructed; the components of the composition are similar to the combination of carbohydrates in the stratum corneum, and the composition can not be washed away due to the unique combination mechanism of the composition and the skin, can up-regulate the gene expression level of filaggrin and hyaluronic acid synthetase 3, promote the synthesis of NMF and hyaluronic acid, and improve the water retention capacity of the skin; can improve the gene expression level of loricrine and influence the function of cornified envelope. Therefore, the water-locking magnet can repair skin microorganism barriers and stratum corneum barriers, enhance the tolerance of the skin and reduce the stimulation caused by external reasons.

The invention balances the skin microbial barrier by the water-locking magnet, endogenously promotes the generation of NMF and hyaluronic acid, and exogenously supplements the skin physiological lipid compound, thereby realizing the repair of the skin double barriers from inside to outside.

Preferably, the nano-encapsulated anti-allergy compound comprises the following components in percentage by mass: 5% of salvia miltiorrhiza extract; stevia leaf/stem extract 5.0-10.0%; 3.0-5.0% of gardenia fruit extract; 1.0% of silymarin; 1.0% of hemp leaf extract; 1.0-5.0% of phospholipid; the balance of polyhydric alcohol and water.

The nano-encapsulated anti-allergy compound has the following active components:

the red sage root extract: inhibiting capsaicin receptor (TRPV1), relieving skin pruritus caused by histamine, inhibiting release of other inflammatory factors after receptor activation, and restoring skin barrier function.

Stevia leaf/stem extract: balancing cell factors, protecting Langerhans cells and immune reconstitution.

Gardenia fruit extract: inhibit the cell inflammatory factors IL-6 and MMP-9.

Silymarin: inhibiting phosphorylation of 1KBa, inhibiting NF-kB activation and translation, and increasing expression of inflammation inhibitor IL-10.

Cannabis leaf extract: containing Cannabidiol (CBD) as an active ingredient, and inhibiting the production of inflammatory factors prostaglandin E2 and leukotriene C4 by inhibiting the activity of cyclooxygenase lipoxygenase; inhibit the inflammatory factor IL-8 and promote the expression of the inflammatory inhibitory factors IL-10 and IL-10R, thereby achieving the purpose of relieving the transmission of uncomfortable feelings such as pain sensation, itch sensation and the like.

Phospholipid: it is unique in its amphiphilicity, i.e., affinity for both fat and water. It plays the role of emulsifier in the nano-encapsulated anti-allergy compound, and the phospholipid is an important component of cell membrane, has high affinity with skin, and is easier to be absorbed and permeated by the skin.

Polyol: the nano-encapsulated anti-allergy compound is used as a dispersing agent, so that the extracts of all the components are uniformly dispersed, and the polyalcohol is used as a humectant to provide a moisturizing effect.

The nano-encapsulated anti-allergy compound disclosed by the invention is complementary and matched in mechanism of each component, comprehensive and synergistic, inhibits a capsaicin receptor (TRPV1), up-regulates the expression of immunity and inflammatory factors, and improves the discomfort caused by inflammatory reaction.

Preferably, the preparation method of the nano-encapsulated anti-allergy compound comprises the following steps:

s1, adding a polyol into a salvia miltiorrhiza extract, a stevia rebaudiana leaf/stem extract, a gardenia fruit extract, silymarin and a hemp leaf extract, and homogenizing and dispersing to obtain a dispersion liquid;

s2, adding water into phospholipid, heating and homogenizing to obtain emulsion;

s3, adding the dispersion liquid into the emulsion, and homogenizing to obtain a pre-dispersion emulsion;

s4, homogenizing the pre-dispersion liquid under the condition of 40-80MPa for 3-5 times to obtain the nano-coated anti-allergy compound.

Compared with the prior art in which the traditional penetration enhancer is adopted to compound active ingredients, the nano-encapsulated anti-allergy compound disclosed by the invention is prepared by selecting various plant extraction essences, and the nano-liposome is used as a carrier to encapsulate the active ingredients, so that the nano-encapsulated anti-allergy compound is better in skin affinity with the skin, and after being absorbed by the skin in a penetrating manner, each active ingredient is slowly released to directly act on a target spot, the active ingredients are ensured to effectively penetrate, the safety of the product is also achieved, and the secondary damage to sensitive skin is avoided. It is known that capsaicin receptor (TRPV1) is a key factor of skin sensitivity problem, and activation of TRPV1 leads to increased vascular reactivity and triggers skin immunity and a series of inflammatory reactions, so that the TRPV1 is antagonized to achieve the therapeutic purpose.

Preferably, the cosmetic composition is in the form of cream, emulsion, gel or aqueous solution.

The composition of the invention can be directly applied to the skin surface, and can also be further used for producing cosmetics or medicaments to be applied to the skin surface.

The invention has the beneficial effects that:

according to the invention, the nano-encapsulated anti-allergic compound antagonizes capsaicin receptor TRPV1, the expression of immune factors (IL-10 and IL-10R) is up-regulated, the immune inflammatory reaction of skin is effectively relieved, the discomfort caused by the damage of the skin barrier and inflammation is improved, the skin microbial barrier is balanced by combining the water-locking magnet, the generation of NMF and hyaluronic acid is endogenously promoted, and the skin physiological lipid complex is exogenously supplemented, so that the skin double barrier is repaired from inside to outside, and various components are reasonably combined and matched for use, so that the effects of quick-acting, slow-releasing, long-acting repairing are achieved, the anti-allergic repairing effect is good, the component action is mild, the use is safe, and the secondary damage to sensitive skin in the using process is effectively avoided.

Drawings

FIG. 1 shows one of the results of the irritation patch test.

FIG. 2 shows one of the results of the irritation patch test.

Fig. 3 shows the results of the stratum corneum hydration test.

Detailed Description

The invention provides a cosmetic composition for anti-allergy repair, which takes the diamagnetic stone, a skin physiological lipid compound and a nano-encapsulated anti-allergy compound as main active ingredients, achieves the effect of anti-allergy repair of skin by repairing double barriers of the skin, antagonizing TRPV1 receptor and up-regulating the expression of immune and inflammatory factors, and has mild effect and safe use.

The present invention will be described in further detail with reference to specific examples, but the embodiments of the present invention are not limited thereto.

Example 1

0.2-4.0% of water-locking magnet;

0.2-3.0% of skin physiological lipid complex;

0.2-4.0% of nano-coated anti-allergy compound;

the balance is common matrix and/or water of the cosmetic external preparation.

The nano-coated anti-allergy compound comprises the following components in percentage by mass: 5% of salvia miltiorrhiza extract; stevia leaf/stem extract 5.0-10.0%; 3.0-5.0% of gardenia fruit extract; 1.0 percent of silymarin; 1.0% of hemp leaf extract; 1.0-5.0% of phospholipid; the balance of polyhydric alcohol and water.

The preparation method of the nano-encapsulated anti-allergy compound comprises the following steps:

The skin physiological lipid compound comprises the following components in percentage by mass:

33.5% of ceramide; c8-12 acid triglyceride 0.3-3.0%; 0.5 to 5.0 percent of cholesterol; hydrogenated lecithin 0.2-2.0%; phytosphingosine 1.5%; 0.5 to 5.0 percent of stearic acid; 0.2 to 2.0 percent of oleic acid; 0.2-2.0% of lactic acid and the balance of water.

Example 2

2% of water-locking magnet;

skin physiological lipid complex 3%;

3% of nano-encapsulated anti-allergy compound;

the balance is common matrix and/or water of the cosmetic external preparation.

The nano-coated anti-allergy compound comprises the following components in percentage by mass:

5% of salvia miltiorrhiza extract; stevia leaf/stem extract 10.0%; 5.0% of gardenia fruit extract; 1.0 percent of silymarin; 1.0% of hemp leaf extract; 5.0% of phospholipid; the balance of polyhydric alcohol and water.

The preparation of the nano-encapsulated anti-sensitivity compound is shown in example 1.

33.5% of ceramide; c8-12 acid triglyceride 0.3%; 0.5% of cholesterol; 0.2% of hydrogenated lecithin; phytosphingosine 1.5%; 0.5 percent of stearic acid; 0.2% of oleic acid; 0.2% of lactic acid and the balance of water.

Example 3

4.0% of water-locking magnet;

skin physiological lipid complex 2%;

2% of nano-encapsulated anti-allergy compound;

the balance is common matrix and/or water of the cosmetic external preparation.

The nano-coated anti-allergy compound comprises the following components in percentage by mass: 5% of salvia miltiorrhiza extract; stevia leaf/stem extract 5.0%; 3.0% of gardenia fruit extract; 1.0 percent of silymarin; 1.0% of hemp leaf extract; 1.0% of phospholipid; the balance of polyhydric alcohol and water.

33.5% of ceramide; c8-12 acid triglyceride 3.0%; 5.0% of cholesterol; 2.0% of hydrogenated lecithin; phytosphingosine 1.5%; 5.0 percent of stearic acid; 2.0% of oleic acid; 2.0% of lactic acid and the balance of water.

Example 4

1% of water-locking magnet;

skin physiological lipid complex 2%;

3% of nano-encapsulated anti-allergy compound;

the balance is common matrix and/or water of the cosmetic external preparation.

The nano-coated anti-allergy compound comprises the following components in percentage by mass: 5% of salvia miltiorrhiza extract; stevia leaf/stem extract 7.5%; fructus Gardeniae extract 4.0%; 1.0 percent of silymarin; 1.0% of hemp leaf extract; 3.0% of phospholipid; the balance of polyhydric alcohol and water.

33.5% of ceramide; c8-12 acid triglyceride 1.5%; 2.8% of cholesterol; 1.1% of hydrogenated lecithin; phytosphingosine 1.5%; 2.7 percent of stearic acid; 1.1% of oleic acid; 1.1% of lactic acid and the balance of water.

Example 5

Anti-allergy repair milk:

an anti-allergy restoration emulsion for anti-allergy restoration comprises the following components in percentage by mass:

oil phase:

water phase:

adding at low temperature after emulsification:

heating the oil phase and the water phase to 75 deg.C respectively, mixing the two phases, homogenizing for several minutes, stirring, cooling to 45 deg.C, adding water-locking magnet, skin physiological lipid complex, nanometer coated anti-allergy compound, antiseptic and essence, stirring, and standing at 35 deg.C to obtain white, fine and uniform emulsion.

Example 6

Anti-allergy repairing gel:

an anti-allergy repairing gel for anti-allergy repairing comprises the following components in percentage by mass:

the preparation method of the anti-allergy repairing gel product comprises the following steps:

(1) mixing Stabylen 30 and PNC 400 with butanediol and deionized water, stirring to dissolve, and stirring to obtain transparent gel matrix;

(2) mixing and stirring the lodestone, the skin physiological lipid compound, the nano-encapsulated anti-allergy compound, the preservative and the gel matrix uniformly, and adding deionized water to the total amount;

(5) and (3) inspecting the gel, and filling after the gel is qualified to obtain the anti-allergy repairing gel skin care product.

Example 7

Anti-allergy repair essence:

an anti-allergy repair essence for anti-allergy repair comprises the following components in percentage by mass:

the preparation method of the anti-allergy repair essence product comprises the following steps:

(1) mixing Stabylen 30 with butanediol and deionized water, and stirring to dissolve;

(2) adding water-locking magnetite, skin physiological lipid compound, nano-encapsulated anti-allergy compound and preservative, mixing and stirring uniformly;

(3) and (4) inspecting the essence, and filling after the essence is qualified to obtain the anti-allergy repair essence skin care product.

Example 8

Anti-allergy repairing toner:

an anti-allergy repairing toner for anti-allergy repairing comprises the following components in percentage by mass:

the preparation method of the anti-allergy repairing toner aquatic product comprises the following steps:

(3) and (3) inspecting the toner, and filling after the toner is qualified to obtain the anti-allergy repairing toner skin care product.

Example 9

Anti-allergy repair cream:

an anti-allergy repair cream for anti-allergy repair comprises the following components in percentage by mass:

oil phase:

water phase:

adding at high temperature after emulsification:

respectively heating the oil phase and the water phase to 75 ℃, mixing and homogenizing the two phases for a plurality of minutes, adding an arginine water solution with the mass percentage of 10%, uniformly stirring, cooling, adding the water locking magnet, the skin physiological lipid compound, the nano-encapsulated anti-allergy compound, the preservative (the preservative is conventionally used in the field) and the essence (the essence is conventionally used in the field) into the mixture after cooling to 45 ℃, uniformly stirring, and standing at 35 ℃ to obtain a white, fine and uniform ointment.

Example 10

Observation on trial

The anti-allergy repair cosmetic prepared by the invention and the control sample are used for observing the curative effect.

Sample preparation: example 9

And (3) comparison: the lodestone, skin physiological lipid complex and nano-encapsulated anti-allergy compound in example 9 were removed.

1. Human body patch experiment

The experimental method comprises the following steps: selecting 30 volunteers, wherein the age composition and the gender of the volunteers are randomly determined and all accord with the people receiving and removing standards of technical specifications for cosmetic safety (2015 edition); selecting the skin on two sides of the upper back vertebra of the volunteer as a tested part, dividing the skin into two parts, wherein one part is a control sample, and the other part is smeared on the embodiment 9, and then firmly sticking the spot tester adhesive tape added with the spot test substance from bottom to top; the patch test time is 48h, the patch tester is removed, the skin state of the tested part is observed after 30min, and the test result is recorded. The patch test is a simple and reliable method for determining the allergen of a patient with dermatitis and eczema, and the detailed operation steps and result judgment refer to the specification of a patch test diagnosis kit (cosmetics series BY-05).

The experimental results are as follows:

example 9 irritation Patch test for samples that reduced the allergen common to 20 cosmetics, the results are shown in FIGS. 1 and 2; as shown in figures 1 and 2, after the skin care product containing the compound of example 9 is applied, the integrity of the epidermal cell membrane structure can be protected to a certain extent, the barrier function of the skin is enhanced, the tolerance of the skin is improved, and the skin care product has the effects of repairing damaged skin and relieving allergic symptoms.

2. Hyaluronidase in vitro inhibition assay

Hyaluronic acid is a component in a tissue matrix for limiting the diffusion of water and other extracellular substances, and after being hydrolyzed by hyaluronidase, cells become non-viscous, so that cell degranulation and new synthesized media are exuded, a biological effect is exerted, and an immediate type allergic reaction is caused. Hyaluronidase is a participant in allergic reactions and has a strong correlation with allergy, and therefore the degree of inhibition of hyaluronidase by a subject is often used to reflect the alleviation and amelioration of type i hypersensitivity.

The experimental method comprises the following steps: respectively preparing 50mg/mL aqueous solution of the example 9 and a control sample as 0.5mL of sample solution, and continuing to perform moisture-preserving culture at 37 ℃ for 20 min; adding 0.5ml sodium hyaluronate solution, keeping moisture at 37 deg.C for 30min, and standing at room temperature for 5 min; adding 0.1mL0.4mol/LNaOH solution and 0.5mL acetylacetone solution, heating in a boiling water bath for 15min, and immediately cooling for 5min with ice water; adding 1.0mL of Ellisib reagent, diluting with 3.0mL of absolute ethanol, standing for 20min for color development, measuring the absorbance value by using a spectrophotometer, and calculating the inhibition rate of hyaluronidase according to the following formula:

the inhibition ratio was [ (A-B) - (C-D) ]/(A-B) × 100%

Wherein A is the absorbance of the control solution (the sample solution is replaced by acetic acid buffer solution); b is the absorbance of the control blank solution (the sample solution and the enzyme solution are replaced by acetic acid buffer solution); c is the absorbance of the sample solution; d is the absorbance of the blank solution (the enzyme solution was replaced by acetic acid buffer solution)

The results of the experiment are shown in table 1:

TABLE 1 Hyaluronidase in vitro inhibition test results

The hyaluronidase inhibition increases with the increase of mass concentration, and the higher the inhibition rate of hyaluronidase under the same mass concentration is, the better the anti-allergy and anti-stimulation effects are.

As is apparent from Table 1, in the same mass concentration, the inhibition rate of example 9 of the present invention on hyaluronidase is significantly higher than that of the control sample, and the anti-allergic and anti-irritant effects are good.

3. Relief test-lactic acid sting test

The experimental method comprises the following steps: 30 face skin sensitive volunteers are selected, male and female are unlimited, and the age is 18-60 years old. The subject site of the subject cannot use any cosmetics, topical drugs or oral healthcare products 15 days before testing. The test environment temperature is 20-22 ℃, and the humidity is 40-60%. The volunteers were applied with 50. mu.l of 10% lactic acid solution to each of the nasolabial folds at both sides, and the sample prepared in example 9 was applied to one nasolabial fold of the volunteers after feeling pain, and the control was applied to the other side. The subjects scored at 30S, 1min, 2.5min and 5min, respectively, and the mean values were taken for evaluation. Scoring according to 4-point method (0 is no feeling, 1 is mild, 2 is medium, 3 is severe) for 2.5min and 5min for positive lactic acid sting with the sum of pricking scores of more than or equal to 3. The test is carried out for 28 days, and the test subject needs to use the product once a day, morning and evening, the higher the score, the greater the irritation, and conversely, the less the irritation.

The results of the experiment are shown in table 2:

as is apparent from the data in Table 2, the component values of the sample group of example 9 decreased more greatly with time than the control group, indicating a significant improvement in irritation after the use of the present invention.

Time (sky)	D1	D3	D7	D14	D28
						Example 9	5.35±1.07	4.52±1.09	3.81±1.12	2.23±1.16	1.36±1.22
Control sample	5.57±1.47	5.20±1.34	4.98±1.38	4.57±1.29	3.98±1.27

TABLE 2 lactic acid stinging test results

4. Moisture retention test:

the experimental method comprises the following steps: 30 volunteers marked 4X 4cm2 test areas on the inner side of the forearms of the left and right hands, respectively, and 2 areas on the same arm, which are the test area and the control area, respectively, with an interval of 2 cm. The test and control areas were measured using a skin moisture tester, with 3 replicates per area. The blank value was measured for each test area and then the sample was applied uniformly to the test area using a latex finger sleeve at a rate of 2.0 + -0.1 mg sample/cm 2, i.e., the control area was coated with the control sample and the test area was coated with example 9. Smeared for 28 days and the skin moisture content was measured in the test and control areas, respectively.

The detection result shows that: after 4 weeks using example 9 of the present invention and the control, as shown in FIG. 3, the results of the stratum corneum moisture test of the skin showed that the moisture content of the base skin of the cosmetic of the present invention was significantly increased compared to the control.

5. Analysis of skin TEWL values

The experimental method comprises the following steps: 30 volunteers were selected, the barrier function of the skin on the dorsiflexion side of both forearms was disrupted with 3% SLS solution, and example 9 and the control were used after manually encountering dermatitis symptoms. The product is used twice a day, once in the morning and once in the evening. TEWL values were measured using a Tewameter at

days

1, 3, 7, 10, 15 of the test area 6h after the skin was disrupted.

The results of the experiment are shown in table 3:

the TEWL value of the test site is an important parameter for evaluating the skin barrier function and the skin repair after using the product, and a smaller value indicates a better skin barrier and a better repair.

As is apparent from the data in table 3, the TEWL value was only slightly decreased after the control was used, the skin barrier repair was poor, and the TEWL value was significantly decreased after the inventive example 9, indicating that the inventive skin barrier repair was excellent.

Time (days)	D_6h	D1	D3	D7	D10	D15
							Example 9	35.68	29.47	19.54	10.28	9.11	8.35
Control sample	37.69	34.70	32.52	28.94	26.78	24.11

TABLE 3 skin TEWL values after use of example 9 and control

Of course, the principle and the embodiments of the present invention are described herein by using specific examples, and the above description of the embodiments is only used to help the method and the core idea of the present invention. It should be noted that, for those skilled in the art, without departing from the principle of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall into the protection scope of the present invention.

Claims

1. The cosmetic composition for anti-allergy restoration is characterized by comprising the following components in percentage by mass:

0.2-4.0% of water-locking magnet;

0.2-3.0% of skin physiological lipid complex;

0.2-4.0% of nano-coated anti-allergy compound;

the balance of common matrix and/or water of the cosmetic external preparation;

2. The cosmetic composition for anti-allergy restoration according to claim 1, wherein the nano-encapsulated anti-allergy compound comprises the following components in percentage by mass: 5% of salvia miltiorrhiza extract; stevia leaf/stem extract 5.0-10.0%; 3.0-5.0% of gardenia fruit extract; 1.0 percent of silymarin; 1.0% of hemp leaf extract; 1.0-5.0% of phospholipid; the balance of polyhydric alcohol and water.

3. The cosmetic composition for anti-allergy restoration according to claim 2, wherein the preparation method of the nano-encapsulated anti-allergy compound comprises the following steps:

4. The cosmetic composition for anti-allergy restoration according to any one of claims 1 to 3, wherein the skin physiological lipid complex comprises the following components in percentage by mass: 33.5% of ceramide; c8-12 acid triglyceride 0.3-3.0%; 0.5 to 5.0 percent of cholesterol; hydrogenated lecithin 0.2-2.0%; phytosphingosine 1.5%; 0.5 to 5.0 percent of stearic acid; 0.2 to 2.0 percent of oleic acid; 0.2-2.0% of lactic acid and the balance of water.

5. The cosmetic composition for anti-allergy restoration according to any one of claims 1 to 3, wherein the water-locking magnetite is an aqueous polysaccharide solution containing 95% of small molecular polysaccharides.

6. The cosmetic composition for anti-allergy restoration according to any one of claims 1 to 3, wherein the dosage form of the cosmetic composition is cream, emulsion, gel or aqueous.