CN111789777A - Skin care cream with immediate tightening and anti-aging effects and preparation method thereof - Google Patents
Skin care cream with immediate tightening and anti-aging effects and preparation method thereof Download PDFInfo
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- CN111789777A CN111789777A CN202010821862.6A CN202010821862A CN111789777A CN 111789777 A CN111789777 A CN 111789777A CN 202010821862 A CN202010821862 A CN 202010821862A CN 111789777 A CN111789777 A CN 111789777A
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- skin
- extract
- aging
- tightening
- skin cream
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Images
Classifications
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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Abstract
The invention discloses a skin cream with instant tightening and anti-aging effects and a preparation method thereof, wherein the skin cream with the instant tightening and anti-aging effects contains 0.01-10.0% of ceramide complex as an active ingredient, 0.001-0.005% of magnesium gluconate, 0.001-0.005% of copper gluconate, 0.1-5.0% of brown algae extract, 0.1-5.0% of rhodophyta extract, 0.01-5.0% of hydroxypropyl tetrahydropyrane triol, 0.01-10.0% of retinol and 0.05-0.2% of arginine/lysine polypeptide. The cream prepared by the invention has stable property, excellent skin affinity and quick absorption, can be used for instantly pulling and firming the skin and realizing instant beauty of the skin; the long-term use of the product can also improve the skin elasticity, reduce fine wrinkles, improve the whole skin aging condition, realize long-acting skin aging resistance and obviously solve the skin aging problem.
Description
Technical Field
The invention belongs to the field of skin care products, and particularly relates to skin care cream with immediate firming and anti-aging effects and a preparation method thereof.
Background
The skin is the natural barrier of human body and has important protection effect on the body. However, the skin of a human body naturally ages with the age, and the conditions of fine wrinkles, skin elasticity reduction, relaxation and the like can occur; in addition, the skin is affected by exogenous aging factors, such as wind, excessive sunlight, muscle movement, insufficient sleep, air pollution, bad life habits, and the like, which often aggravate the generation of wrinkles and skin laxity.
Modern people have wide social activities, and increasingly pursue the state that the skin of people is always bright and beautiful, so that the skin is pursued to be beautiful and the skin is pursued to be long-acting, tender and elastic.
Many anti-aging cosmetics on the market use antioxidants to reduce the production of free radicals in the body or promote the synthesis of collagen and elastin in the skin to achieve the anti-aging purpose. However, most of these substances are large molecules, and are difficult to permeate into the inner layer of the skin to exert the effect, and the service cycle is too long, so that the substances are difficult to be accepted by consumers. The formulation design adopts the combination of grease with excellent affinity, micromolecule active substances and penetration enhancer to develop the composition which can quickly make the functional substance enter human skin, immediately lift and tighten the skin and realize the instant beauty of the skin; the product which can improve the skin elasticity, reduce fine wrinkles and improve the whole skin aging condition after long-term use can really and efficiently achieve the aim of resisting aging.
Disclosure of Invention
The invention aims to provide a skin-care cream with immediate tightening and anti-aging effects, which has stable property, excellent skin affinity, quick absorption, capability of realizing immediate tightening and long-acting anti-aging of skin and obvious solution to the problem of skin aging.
Another object of the present invention is to provide a method for preparing the above cosmetic with instant firming and anti-aging effects.
It is still another object of the present invention to provide the use of the above instant firming anti-aging cosmetic.
The above purpose of the invention is realized by the following technical scheme:
a skin cream with immediate tightening and anti-aging effects comprises A, B, C and D, wherein the components in each part are calculated according to the percentage of the total mass of the cosmetic, wherein, the component in the A part comprises 2 to 5 percent of emulsifier, 15 to 25 percent of grease and 0.1 to 0.5 percent of antioxidant; the component of part B is 0.3-0.5% of emulsifier, 10-15% of humectant, 100% of deionized water, 0.3-1.0% of thickener, 0.1-0.6% of penetration enhancer and 0.05-0.1% of chelating agent; the component of the part C is 0.5-0.8% of preservative; the D part is 0.01-10.0% of ceramide compound, 0.001-0.005% of magnesium gluconate, 0.001-0.005% of copper gluconate, 0.1-5.0% of brown algae extract, 0.1-5.0% of rhodophyta extract, 0.01-5.0% of hydroxypropyl tetrahydropyrane triol, 0.01-10.0% of retinol and 0.05-0.2% of arginine/lysine polypeptide.
Further, the emulsifier in the part A is one or a mixture of more of polyglycerol-3 methyl glucose distearate, cetearyl alcohol, monoglyceride, methyl glucose sesquistearate and hydrogenated lecithin; the oil is one or more of stearyl alcohol heptanoate, caprylic/capric triglyceride, hydrogenated sunflower seed oil, cyclopentadimethylsiloxane, diethylhexyl carbonate, buckeye resin, octyl methylsiloxane, polydimethylsiloxane, lanolin, shea butter, jojoba oil and isopropyl myristate; the antioxidant is tocopherol.
Further, the humectant in the part B is one or a mixture of more of glycerol, propylene glycol, hydroxyethyl urea, 1, 3-butanediol, trehalose, sodium hyaluronate, phytosphingosine, cholesterol and glucan; the emulsifier is sodium lauroyl lactylate; the thickener is at least one of carbomer, xanthan gum, sodium polyacrylate and hydroxyethyl cellulose; the penetration enhancer is heparin sodium; the chelating agent is disodium hexamethylenediamine tetraacetate.
Furthermore, the preservative in the part C is one or a mixture of more of methyl hydroxybenzoate, ethyl hydroxybenzoate, phenoxyethanol and hexanediol.
Furthermore, the molecular weight of the sodium hyaluronate of the B site moisturizing agent is 5 ten thousand.
The ceramide compound provided by the invention contains a mixture of biomimetic ceramide 3, ceramide 6II, ceramide 1, phytosterol and biomimetic skin natural lipid barrier, can act synergistically with the natural protective barrier of the skin, and can prevent water loss of the skin and resist external influence.
The extract of Haematococcus sp is specifically: one or more of Chondrus crispus extract, Hypnea charoides extract, and Eucheuma Gelatinosum extract; the brown algae extract is specifically as follows: one or more of Fucus serratus extract and Sargassum blunt extract. Is rich in algae colloid, brown algae polyphenol, sodium alginate, algae carotene and marine microelements, and can increase skin elasticity, improve skin mechanical property, repair skin barrier function, promote synthesis of collagen and elastin, and inhibit generation of degrading enzyme, thereby improving skin elasticity, wrinkle and texture.
The hydroxypropyl tetrahydropyrane triol is one of xylose derivatives, can promote the synthesis of glycosaminoglycans (GAGs) and proteoglycan in skin, and can also promote the synthesis of collagen VII and collagen IV, thereby strengthening the connection between epidermis and dermis, relieving skin aging, playing the roles of promoting the repair of dermis, improving the moisture content of skin, improving the elasticity of skin and increasing the skin tightness, and leading the skin to be more exquisite and glossy.
The retinol is subjected to wrapping treatment, the retinol is an active part of vitamin A, and a plurality of researches prove that the retinol has remarkable effect, can stimulate the generation of new collagen to resist skin aging and reduce wrinkles; improve the appearance of damaged skin caused by ultraviolet irradiation, and maintain the softness and elasticity of the skin. However, because it is very sensitive to light, heat and high-valence metal ions and has poor stability, it is easy to cause skin allergy and other factors, so that it cannot be widely applied in the cosmetic industry. The cosmetic delivery system wrapped with 8% retinol is used in the invention, which aims at solving the common formulation challenge of retinol, strengthening the stability and bioavailability of retinol and reducing the irritation thereof.
The arginine/lysine polypeptide is a biological simulated conotoxin polypeptide, is synthesized by specific sequencing, and provides a strong relaxation effect on muscles with skin controlling expression. However, this relaxation does not cause the muscles to become completely rigid and paralyzed, and can preserve 5% of the neuromuscular current conduction, but can provide immediate anti-wrinkle effects. The arginine/lysine polypeptide has definite targeting property, low concentration and high effect, good transdermal effect and high stability.
Copper gluconate, copper, helps prevent the oxidation of vitamin C and promotes the synthesis of skin elastin. Copper plays an important role in the formation of tyrosinase. In addition, copper is a key mineral for maintaining skin health. Enhancing skin firmness. Enhancing the skin's ability to fight free radicals.
The invention also provides a preparation method of the instant tightening and anti-aging skin cream, which specifically comprises the following steps:
s1, adding polyglycerol-3-methylglucose distearate, hydrogenated lecithin, stearyl heptanoate, caprylic/capric triglyceride, cetostearyl alcohol, hydrogenated sunflower seed oil, cyclopentadimethylsiloxane, diethylhexyl carbonate, buckeye resin, octyl methylsiloxane, polydimethylsiloxane and vitamins into an oil phase pot, stirring and heating to 85 ℃ at a stirring speed of 300r/min, and stirring until the materials are completely dissolved to obtain a material A;
s2, adding water, heparin sodium, glycerol, 1, 3-butanediol, trehalose, ethylene diamine tetraacetic acid disodium, sodium hyaluronate (5w), sodium polyacrylate, hydroxyethyl cellulose and methyl hydroxybenzoate into a water phase pot, stirring and heating to 80 ℃ at a stirring speed of 500r/min, and stirring until the materials are completely dissolved to obtain a material B;
s3, mixing the material B and the material A in an emulsifying pot, and homogenizing at 6000r/min for 3min until the materials are uniformly emulsified;
s4, after emulsification, adding 1, 2-hexanediol, stirring at 500r/min for uniform dispersion, and cooling;
s5, when the temperature is reduced to below 40 ℃, adding ceramide complex, magnesium gluconate, copper gluconate, brown algae extract, rhodophyta extract, hydroxypropyl tetrahydropyrane triol, retinol and arginine/lysine polypeptide, uniformly stirring at 500r/min, cooling to room temperature, sampling, checking, and discharging to obtain the cream with the effects of tightening and resisting aging.
Compared with the prior art, the invention has the advantages that: not only can realize instant tight effect, long-term use can also reduce the wrinkle, alleviates skin aging state, and skin is more full. By adding multiple anti-aging components, the skin aging such as natural aging, photoaging and the like caused by different reasons is solved, and a more effective anti-aging effect is achieved; meanwhile, the preparation method of the instant firming anti-wrinkle cream has stable process. The added ceramide has the same structure as ceramide in human skin, has good skin-friendly property, prevents water loss and reduces the influence of external environment by repairing skin barrier, and keeps skin moisture. The added brown algae extract and red algae extract have good affinity with skin, can form a hydrophilic film on the skin, has a very high-efficient moisturizing effect, and simultaneously, the magnesium gluconate provides magnesium ions for the skin to resist the contraction action of calcium ions on the skin, so that the elasticity and the thickness of the skin can be improved in a short time.
Drawings
The above features and advantages of the present invention will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings, in which:
fig. 1 example 13D wrinkle texture map, demonstrating the significant wrinkle improvement effect, and skin anti-aging.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below, but the embodiments of the present invention are not limited thereto, and process parameters or conditions not particularly noted may be performed with reference to conventional techniques.
Example 1
A skin care cream with immediate tightening and anti-aging effects is prepared from the following raw materials in percentage by weight: polyglycerol-3-methylglucidistearate 2.5%, hydrogenated lecithin 0.5%, stearyl heptanoate 1.5%, caprylic/capric triglyceride 2.5%, cetearyl alcohol 1.5%, hydrogenated sunflower seed oil 2.5%, cyclopentadimethylsiloxane 3%, diethylhexyl carbonate 2.0%, buckeye resin 2.0%, octylmethylsiloxane 1.5%, polydimethylsiloxane 2.5%, vitamin E0.05%, heparin sodium 0.2%, glycerol 4.0%, 1, 3-butylene glycol 4.0%, trehalose 1.0%, disodium ethylenediaminetetraacetate 0.05%, sodium hyaluronate (5w) 0.05%, sodium polyacrylate 0.15%, hydroxyethyl cellulose 0.15%, 1, 2-hexanediol 0.5%, methylparaben 0.15%, ceramide complex 2.0%, magnesium gluconate 0.002%, copper gluconate 0.003%, brown algae 2%, algae extract 3%, hydroxypropyl tetranethylol 0.5%, 1.0 percent of retinol, 0.1 percent of arginine/lysine polypeptide and the balance of water.
Example 2
A skin care cream with immediate tightening and anti-aging effects is prepared from the following raw materials in percentage by weight: polyglycerol-3-methylglucidistearate 2.0%, hydrogenated lecithin 1.0%, stearyl heptanoate 1.8%, caprylic/capric triglyceride 2.2%, cetearyl alcohol 1.0%, hydrogenated sunflower seed oil 3.5%, cyclopentadimethylsiloxane 2.5%, diethylhexyl carbonate 2.5%, buckeye resin 2.2%, octylmethylsiloxane 1.3%, polydimethylsiloxane 2.5%, vitamin E0.05%, heparin sodium 0.15%, glycerol 5.0%, 1, 3-butylene glycol 3.0%, trehalose 1.0%, disodium ethylenediaminetetraacetate 0.05%, sodium hyaluronate (5w) 0.05%, sodium polyacrylate 0.15%, hydroxyethyl cellulose 0.15%, 1, 2-hexanediol 0.5%, methyl hydroxybenzoate 0.15%, ceramide complex 0.5%, magnesium gluconate 0.001%, copper gluconate 0.005%, brown algae extract 5.0%, red algae extract 0.1%, hydroxypropyl triol 5.0%, 0.1% of retinol, 0.05% of arginine/lysine polypeptide and the balance of water.
Example 3
A skin care cream with immediate tightening and anti-aging effects is prepared from the following raw materials in percentage by weight: polyglycerol-3-methylglucdistearate 1.5%, hydrogenated lecithin 1.5%, stearyl heptanoate 2.0%, caprylic/capric triglyceride 1.5%, cetearyl alcohol 2.0%, hydrogenated sunflower seed oil 2.5%, cyclopentadimethylsiloxane 2.5%, diethylhexyl carbonate 2.5%, byssus 2.0%, octylmethylsiloxane 1.0%, polydimethylsiloxane 3.0%, vitamin E0.05%, heparin sodium 0.2%, glycerol 3.0%, 1, 3-butylene glycol 5.0%, trehalose 1%, disodium ethylenediaminetetraacetate 0.05%, sodium hyaluronate (5w) 0.08%, sodium polyacrylate 0.2%, hydroxyethyl cellulose 0.1%, 1, 2-hexanediol 0.5%, methylparaben 0.15%, ceramide complex 5%, magnesium gluconate 0.005%, copper gluconate 0.001%, brown algae extract 0.1%, red algae extract 5.0%, hydroxypropyl tetrahydropyran 3%, retinol 8%, arginine/lysine polypeptide 0.2%, and water in balance.
Example 4
A method for preparing skin cream with immediate tightening and anti-aging effects comprises:
s1, adding polyglycerol-3-methylglucose distearate, hydrogenated lecithin, stearyl heptanoate, caprylic/capric triglyceride, cetostearyl alcohol, hydrogenated sunflower seed oil, cyclopentadimethylsiloxane, diethylhexyl carbonate, buckeye resin, octyl methylsiloxane, polydimethylsiloxane and vitamins into an oil phase pot, stirring and heating to 85 ℃ at a stirring speed of 300r/min, and stirring until the materials are completely dissolved to obtain a material A;
s2, adding water, heparin sodium, glycerol, 1, 3-butanediol, trehalose, ethylene diamine tetraacetic acid disodium, sodium hyaluronate (5w), sodium polyacrylate, hydroxyethyl cellulose and methyl hydroxybenzoate into a water phase pot, stirring and heating to 80 ℃ at a stirring speed of 500r/min, and stirring until the materials are completely dissolved to obtain a material B;
s3, mixing the material B and the material A in an emulsifying pot, and homogenizing at 6000r/min for 3min until the materials are uniformly emulsified;
s4, after emulsification, adding 1, 2-hexanediol, stirring at 500r/min for uniform dispersion, and cooling;
s5, when the temperature is reduced to below 40 ℃, adding ceramide complex, magnesium gluconate, copper gluconate, brown algae extract, rhodophyta extract, retinol, hydroxypropyl tetrahydropyrane triol and arginine/lysine polypeptide, uniformly stirring at 500r/min, cooling to room temperature, sampling, checking, and discharging after qualified to obtain the cream with the effects of tightening and resisting aging.
Comparative example 1
The difference from example 1 is that only hydroxypropyl tetrahydropyrane triol is added.
Comparative example 2
The difference from example 1 is that only retinol is added.
Comparative example 3
The difference from example 1 is that only the arginine/lysine polypeptide is added.
Comparative example 4
The difference from example 1 is that the brown algae extract and the alga extract of the phylum Rhodophyta were not added.
Comparative example 5
The difference from example 1 is that only brown algae extract and red algae extract were added.
Efficacy verification
Product safety evaluation (human body skin patch experiment)
Test products: examples and comparative examples cream prepared
Number of test population: 50 people, 25 people each for male and female
Age: between 25 and 45 years of age
Health condition: the skin of the subject is healthy, has no allergic history of the skin disease, and meets the voluntary selection standard of the subject.
Grouping: 5 groups of 10 persons each, mean age 33 + -2 years
The spot pasting method comprises the following steps: selecting a qualified spot tester, dripping 0.020-0.025 g of a test object into the spot tester in a closed spot test mode, externally sticking a special adhesive tape on the inner side of the thigh of the test object, removing the test object after 24 hours, observing skin reactions after 0.5, 6, 12, 24 and 48 hours after the test object is removed respectively, and recording the results according to the skin reaction grading standard in technical Specification for cosmetic safety (2015 edition).
The experimental results are as follows: the result of the human body skin patch test shows that: skin reactions of 0.5, 6, 12, 24 and 48 hours are observed through patch tests of the creams of the examples and the comparative examples of the subjects, wherein 0 case has adverse skin reactions, which indicates that the skin care cream with instant tightening and anti-aging effects is non-irritant and safe.
Evaluation of efficacy- -testing of skin elasticity at the canthus
Test products: skin cream prepared by the following examples and comparative examples
Selection of volunteers: selecting healthy volunteers with the age of 25-50 years, no serious skin disease history and no cosmetic allergy history, and not limiting gender and skin types.
The testing steps are as follows: before the test, a test subject uniformly uses the mild and non-fragrant amino acid facial cleanser to clean the face, and then uses a skin elasticity measuring instrument to measure the initial elasticity of the face in a constant-temperature and constant-humidity efficacy evaluation room. Then different volunteers are required to use the same dosage, the skin elasticity change condition of the canthus position is tested at 0.5, 1 and 2 hours, and the absolute value of the skin elasticity index is recorded.
Specification of indexes: ISE value: instant skin elasticity, N/m, higher readings indicate better skin elasticity. This number is indicative of the distribution of pressure when the measurement probe is placed on the skin, the dimensions of the indentor being optimized to measure the mechanics of the skin, rather than the skin moving with the depth of the color during the measurement of the subcutaneous tissue.
Statistical analysis: and (3) performing data analysis on the score of the skin elasticity index of the canthus of the volunteer participating in the efficacy evaluation by adopting an SPSS17.0 data statistical system, performing matched sample T test on the data before the cream trial and the data 0.5, 1 and 2 hours after the cream trial, wherein the significance level is a 95% confidence interval (P <0.05), and analyzing whether significant difference exists before and after the cream trial.
The test results are given in table 1 below.
TABLE 1 test results of examples and comparative examples
| Test items | Before testing | 0.5h | 1h | 2h | |
| Example 1 | Canthus skin elasticity | 29 | 49* | 46* | 45* |
| Example 2 | Canthus skin elasticity | 28 | 43* | 40* | 39* |
| Example 3 | Canthus skin elasticity | 30 | 41* | 40* | 38* |
| Comparative example 1 | Canthus skin elasticity | 29 | 29- | 26- | 23- |
| Comparative example 2 | Canthus skin elasticity | 28 | 27- | 30- | 25- |
| Comparative example 3 | Canthus skin elasticity | 25 | 29* | 28- | 26- |
| Comparative example 4 | Canthus skin elasticity | 33 | 36* | 34- | 30- |
| Comparative example 5 | Canthus skin elasticity | 31 | 36* | 33- | 32- |
Note that "+" in the table indicates that the product has a significant difference (P <0.05) after use and before use at the corresponding time, and "-" indicates that the product has no significant difference (P > 0.05).
As can be seen from the data in Table 1: examples 1-3 compared to comparative examples 1-5, example 1 has a better immediate tightening effect. The fact that the brown algae extract and the rhodophyta extract are reasonably compounded with the hydroxypropyl tetrahydropyrane triol, the retinol and the arginine/lysine polypeptide in the cream with the instant firming and anti-aging effects can achieve a better effect of firming skin immediately.
Evaluation of anti-aging efficacy- -testing of canthus wrinkles and texture
Test products: examples and comparative examples cream prepared
Selection of volunteers: selecting healthy volunteers with age of 35-60 years, no serious skin disease history and no cosmetic allergy history, and not limiting gender and skin types.
The testing steps are as follows: before the test, the testee uses the mild and non-fragrant amino acid facial cleanser to clean the face uniformly, and then uses an ANTERA 3D imaging analyzer to take a picture in a constant-temperature constant-humidity efficacy evaluation room to record the initial facial condition. Different volunteers were then asked to apply one of the creams of the examples/comparative examples uniformly in the morning and evening, massage to complete absorption and pause the use of the other cosmetic, test was continued for 4 weeks, and at 1 week, 2 weeks, 4 weeks after use, each visit was made once, three times in total, each visit being at the same time of day, and the absolute scores of each of the two skin indicators in the corner of the eye and wrinkles were recorded for different volunteers using different creams.
Specification of indexes:
and (3) texture indexes:
average roughness, Ra: evaluating an average of all deviations from a line within the length, regardless of vertical orientation;
root mean square roughness, Rq: is the root mean square average of the roughness ordinate;
wrinkle index:
indentation index: similar to the definition of roughness, except that only negative vertical deviations from its ideal form of the surface are considered;
maximum depth: this is the maximum depth of the selected wrinkle, measured in mm.
Statistical analysis: and (3) performing data analysis on scores of two indexes in the canthus veins and wrinkles of the volunteer participating in the efficacy evaluation by adopting an SPSS17.0 data statistical system, performing matched sample T test on the data before sample trial and the data 1 week, 2 weeks and 4 weeks after use, wherein the significance level is a confidence interval (P <0.05) of 95%, and analyzing whether significant difference exists before and after use.
The test results are shown in table 2 below.
Table 2 test results of examples and comparative examples
Note that "+" in the table indicates that the product has a significant difference (P <0.05) after use and before use at the corresponding time, and "-" indicates that the product has no significant difference (P >0.05)
From table 2 above, it can be seen that: compared with the results of the comparative examples 1 to 5, the examples 1 to 3 have better immediate tightening and anti-aging effects than the comparative examples, especially the example 1, and the specific wrinkle effect graph of the texture can be seen in the attached figure 1, which shows that the reasonable compounding of the three anti-wrinkle components has more obvious wrinkle improving effect than the single use of one anti-wrinkle component. The aging problem caused by different reasons can be improved by compounding the three raw materials, and a synergistic effect is achieved; meanwhile, the brown algae extract and the rhodophyta extract can also enhance the wrinkle improving effect of the three components and realize skin aging resistance.
The above results demonstrate that the instant firming and anti-aging skin cream formulation provided by the present invention is not obtained by simple combination of the components, further demonstrating the synergistic effect among the components of the formulation of the present invention. Meanwhile, no allergy phenomenon occurs in all the subjects, and the conditions of skin itch, stabbing pain, red swelling and the like do not occur. Therefore, the instant firming and anti-aging skin cream is mild and safe and can be used for a long time.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (7)
1. The skin cream with the instant tightening and anti-aging effects is characterized by comprising A, B, C and D, wherein the component A comprises 2-5% of an emulsifier, 15-25% of grease and 0.1-0.5% of an antioxidant; the component of part B is 0.3-0.5% of emulsifier, 10-15% of humectant, 100% of deionized water, 0.3-1.0% of thickener, 0.1-0.6% of penetration enhancer and 0.05-0.1% of chelating agent; the component of the part C is 0.5-0.8% of preservative; the D part is 0.01-10.0% of ceramide compound, 0.001-0.005% of magnesium gluconate, 0.001-0.005% of copper gluconate, 0.1-5.0% of brown algae extract, 0.1-5.0% of rhodophyta extract, 0.01-5.0% of hydroxypropyl tetrahydropyrane triol, 0.01-10.0% of retinol and 0.05-0.2% of arginine/lysine polypeptide.
2. The skin cream with immediate tightening and anti-aging effects according to claim 1, wherein the ceramide complex comprises ceramide 3, ceramide 6II, ceramide 1, phytosterol.
3. The skin cream having immediate firming and anti-aging efficacy according to claim 1, wherein said extract of algae of the phylum rhodophyta is: one or more of Chondrus crispus extract, Hypnea charoides extract, and Eucheuma Gelatinosum extract; the brown algae extract is specifically as follows: one or more of Fucus serratus extract and Sargassum blunt extract.
4. The skin cream with immediate tightening and anti-aging efficacy according to claim 1, wherein the hydroxypropyl tetrahydropyrane triol is one of the derivatives of xylose.
5. The skin cream with immediate tightening and anti-aging efficacy according to claim 1, wherein the retinol is coated with 8% retinol.
6. The skin cream having immediate tightening and anti-aging effects of claim 1, wherein the arginine/lysine polypeptide is a biomimetic conotoxin polypeptide.
7. The skin cream having immediate tightening and anti-aging effects according to claim 1, wherein the skin cream having immediate tightening and anti-aging effects is prepared by a method comprising the steps of:
s1, adding polyglycerol-3-methylglucose distearate, hydrogenated lecithin, stearyl heptanoate, caprylic/capric triglyceride, cetostearyl alcohol, hydrogenated sunflower seed oil, cyclopentadimethylsiloxane, diethylhexyl carbonate, buckeye resin, octyl methylsiloxane, polydimethylsiloxane and vitamins into an oil phase pot, stirring and heating to 85 ℃ at a stirring speed of 300r/min, and stirring until the materials are completely dissolved to obtain a material A;
s2, adding water, heparin sodium, glycerol, 1, 3-butanediol, trehalose, ethylene diamine tetraacetic acid disodium, sodium hyaluronate (5w), sodium polyacrylate, hydroxyethyl cellulose and methyl hydroxybenzoate into a water phase pot, stirring and heating to 80 ℃ at a stirring speed of 500r/min, and stirring until the materials are completely dissolved to obtain a material B;
s3, mixing the material B and the material A in an emulsifying pot, and homogenizing at 6000r/min for 3min until the materials are uniformly emulsified;
s4, after emulsification, adding 1, 2-hexanediol, stirring at 500r/min for uniform dispersion, and cooling;
s5, when the temperature is reduced to below 40 ℃, adding ceramide complex, magnesium gluconate, copper gluconate, brown algae extract, rhodophyta extract, hydroxypropyl tetrahydropyrane triol, retinol and arginine/lysine polypeptide, uniformly stirring at 500r/min, cooling to room temperature, sampling, checking, and discharging to obtain the skin cream with the effects of tightening and resisting aging immediately.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618404A (en) * | 2020-12-02 | 2021-04-09 | 天津芸熙生物技术有限公司 | Application of sandalwood polypeptide in preparation of skin care product and composition thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953772A (en) * | 2010-09-21 | 2011-01-26 | 广州舒泰生物技术有限公司 | Whitening sunscreen cosmetic and preparation method and application thereof |
| CN108578324A (en) * | 2018-07-02 | 2018-09-28 | 上海新高姿化妆品有限公司 | A kind of skin cream and preparation method thereof with long-acting moisture-keeping efficacy |
| CN108721186A (en) * | 2018-08-02 | 2018-11-02 | 江西登云健康美业互联有限公司 | A kind of anti-ageing face cream and preparation method thereof |
| CN110013447A (en) * | 2019-03-13 | 2019-07-16 | 广州雅纯化妆品制造有限公司 | A kind of cream and preparation method thereof for dispelling striae of pregnancy |
| CN110448494A (en) * | 2019-09-08 | 2019-11-15 | 葆姿(成都)健康管理有限公司 | A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect |
| CN111407698A (en) * | 2020-04-20 | 2020-07-14 | 广州市帝臣日化科技有限公司 | Wrinkle-removing moisturizing skin care lotion and preparation method thereof |
-
2020
- 2020-08-15 CN CN202010821862.6A patent/CN111789777A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953772A (en) * | 2010-09-21 | 2011-01-26 | 广州舒泰生物技术有限公司 | Whitening sunscreen cosmetic and preparation method and application thereof |
| CN108578324A (en) * | 2018-07-02 | 2018-09-28 | 上海新高姿化妆品有限公司 | A kind of skin cream and preparation method thereof with long-acting moisture-keeping efficacy |
| CN108721186A (en) * | 2018-08-02 | 2018-11-02 | 江西登云健康美业互联有限公司 | A kind of anti-ageing face cream and preparation method thereof |
| CN110013447A (en) * | 2019-03-13 | 2019-07-16 | 广州雅纯化妆品制造有限公司 | A kind of cream and preparation method thereof for dispelling striae of pregnancy |
| CN110448494A (en) * | 2019-09-08 | 2019-11-15 | 葆姿(成都)健康管理有限公司 | A kind of skin care compositions and its application and preparation method with anti-ageing reparation effect |
| CN111407698A (en) * | 2020-04-20 | 2020-07-14 | 广州市帝臣日化科技有限公司 | Wrinkle-removing moisturizing skin care lotion and preparation method thereof |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618404A (en) * | 2020-12-02 | 2021-04-09 | 天津芸熙生物技术有限公司 | Application of sandalwood polypeptide in preparation of skin care product and composition thereof |
| CN112691070A (en) * | 2021-01-27 | 2021-04-23 | 深圳市琉璃光生物科技有限公司 | Anti-aging composition, eye cream and preparation method thereof |
| CN112999110A (en) * | 2021-03-23 | 2021-06-22 | 上海极爱生物科技有限公司 | Retinal anti-wrinkle nano essence emulsion and preparation method thereof |
| CN112932990A (en) * | 2021-04-15 | 2021-06-11 | 广州樊文花化妆品有限公司 | Anti-aging composition and preparation method and application thereof |
| CN113181073A (en) * | 2021-04-30 | 2021-07-30 | 广州市科能化妆品科研有限公司 | Composite vitamin emulsion, wrinkle-removing essence cream and preparation method thereof |
| CN113181073B (en) * | 2021-04-30 | 2022-12-23 | 广州市科能化妆品科研有限公司 | Composite vitamin emulsion, wrinkle-removing essence cream and preparation method thereof |
| CN113456525A (en) * | 2021-05-25 | 2021-10-01 | 上海达尔威生物技术研发有限公司 | Polysaccharide liposome containing hyaluronic acid, hydroxypropyl tetrahydropyrane triol and phytosphingosine derivative and preparation method thereof |
| CN113521254A (en) * | 2021-06-22 | 2021-10-22 | 广州恒宁生物科技有限公司 | Composition containing liposome-encapsulated thymosin as well as preparation method and application thereof |
| CN114177104A (en) * | 2021-11-25 | 2022-03-15 | 湖州中科锦肽生物科技有限公司 | Anti-aging face cream |
| CN114712285A (en) * | 2022-04-20 | 2022-07-08 | 皓雨(广州)化妆品制造有限公司 | Composition with anti-wrinkle effect and preparation method and application thereof |
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