CN114177104A - Anti-aging face cream - Google Patents
Anti-aging face cream Download PDFInfo
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- CN114177104A CN114177104A CN202111409737.5A CN202111409737A CN114177104A CN 114177104 A CN114177104 A CN 114177104A CN 202111409737 A CN202111409737 A CN 202111409737A CN 114177104 A CN114177104 A CN 114177104A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
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Abstract
The invention provides anti-aging cream, and relates to the field of biology and cosmetics. The anti-aging cream takes pentaerythritol tetra (ethyl hexanoate), hydrogenated polyisobutene and the like as emollients, butanediol, biogum-1, 2-hexanediol, allantoin and the like as humectants, hydroxypropyl tetrahydropyrane triol, glycerol glucose, glycerol, ceramide NS/ceramide NG, stearic acid, cholesterol, bisabolol, cycloastragenol and the like as skin conditioners, polyglycerol-10 distearate, glycerol behenate, cetearyl alcohol, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer and the like as emulsifiers, polydimethylsiloxane as an antifoaming agent, and tocopherol acetate and p-hydroxyacetophenone as antioxidants. Experiments show that the product has good anti-aging effect by adopting the combination of hydroxypropyl tetrahydropyrane triol and cycloastragenol.
Description
Technical Field
The invention relates to the technical field of biology and cosmetics, in particular to anti-aging face cream.
Background
As the body ages and various physiological functions become disordered, many chronic diseases become risk factors for the health of the body. The occurrence of diseases can bring great burden to the families and the society of people. Therefore, prevention of aging-related diseases, healthy "aging" has been the focus of attention. The theory of telomeres is one of the more influential theories in the current aging mechanism, and cycloastragenol is a natural active ingredient which is extracted from the traditional Chinese medicine astragalus root and can activate telomerase. In recent years, through more intensive research on the pharmacological action of CAG, the CAG not only can activate telomerase, but also has various pharmacological activities of resisting inflammation, resisting oxidation, resisting ischemia and hypoxia injury, resisting lipid accumulation, promoting wound healing and the like. Therefore, CAG not only becomes a hotspot of anti-aging drug research, but also is an important raw material of anti-aging health products, foods and cosmetics.
Hydroxypropyl tetrahydropyran triol is considered to be an "immortal component" of anti-aging. Research shows that the anti-aging mechanism of hydroxypropyl tetrahydropyrane triol is probably related to the following three channels: promoting glycosaminoglycan synthesis: glycosaminoglycan is one of the components of human extracellular matrix, has strong hydrophilicity, can help to keep water in loose connective tissue, has the effect of promoting wound healing, and has remarkable moisturizing effect. The hydroxypropyl tetrahydropyrane triol serving as the xylose derivative can promote the synthesis of glycosaminoglycan, indirectly increase the production of dermal collagen, and achieve the effects of promoting dermal repair, improving skin elasticity and increasing skin firmness. Promoting collagen in-vivo regeneration and reducing wrinkles: the hydroxypropyl tetrahydropyrane triol can promote the acceleration of the production of type IV and type VII collagen by cells in the dermis layer, strengthen the connection of the dermis and the epidermis, fill glycosaminoglycan in the network of the type IV collagen and the like, improve the skin relaxation phenomenon caused by the aging and further reduce wrinkles. Help the skin to absorb the active ingredients in the cosmetic: from the chemical structure, the hydroxypropyl tetrahydropyrane triol is one of ethers, belongs to a nonionic surfactant, has remarkable dispersing and emulsifying capacity and excellent skin permeability, and can effectively help other active ingredients to permeate through the skin and be absorbed.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the anti-aging cream which can delay aging and tighten skin.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: an anti-aging cream is prepared from the following raw materials in parts by weight: 3-5 parts of pentaerythritol tetra (ethyl hexanoate), 2-4 parts of butanediol, 2-4 parts of hydroxypropyl tetrahydropyran triol, 0.5-1.5 parts of glycerol glucoside, 0.5-1.5 parts of glycerol, 0.5-1.5 parts of polyglycerol-10 distearate, 10.5-1.5 parts of biogan gum, 0.5-1.5 parts of hydrogenated polyisobutene, 0.5-1.5 parts of shea butter, 0.25-0.75 part of glyceryl behenate, 0.25-0.75 part of cetearyl alcohol, 0.25-0.75 part of polydimethylsiloxane, 0.25-0.75 part of tocopheryl acetate, 0.25-0.75 part of p-hydroxyacetophenone, 0.25-0.75 part of 1, 2-hexanediol, 0.05-0.15 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.05-0.15 part of isohexadecane, 0.05-0.15 part of polysorbate, 0.15-3515 parts of sorbitan ester, 0.05-15 parts of ceramide, 0.05-15 parts of NS 0.05/15 parts of ceramide, 0.05-0.15 part of stearic acid, 0.05-0.15 part of cholesterol, 0.05-0.15 part of polyglycerol-10 stearate, 0.05-0.15 part of allantoin, 0.05-0.15 part of bisabolol, 0.05-0.15 part of cycloastragenol, 0.05-0.15 part of tetrandra root extract, 0.05-0.15 part of dipropylene glycol, 0.05-0.15 part of hydrogenated lecithin, 0.05-0.15 part of tremella polysaccharide, 0.05-0.15 part of tetrahydromethylpyrimidine carboxylic acid, 10.05-0.15 part of tripeptide-10.05, 0.05-0.15 part of sodium hyaluronate, 0.05-0.15 part of dipeptide diaminobutyryl benzylamide diacetate, 0.36-0.015 part of acetyl hexapeptide-80.005, 0.005-0.015 part of arginine/lysine polypeptide, 0.015-50.005 part of acetyl tetrapeptide-539 2, 0.015-10.005 part of palmitoyl tripeptide, 0.015-10.005 part of palmitoyl peptide, 0.0075-365-70.0025 parts of purified water, and 0.0075-100 parts of palmitoyl peptide.
Preferably, the feed is prepared from the following raw materials in parts by weight: 4 parts of pentaerythritol tetra (ethyl hexanoate), 3 parts of butanediol, 3 parts of hydroxypropyl tetrahydropyrane triol, 1 part of glycerol glucoside, 1 part of glycerol, 1 part of polyglycerol-10 distearate, 11 parts of biogan gum, 1 part of hydrogenated polyisobutene, 1 part of shea butter, 0.5 part of glyceryl behenate, 0.5 part of cetostearyl alcohol, 0.5 part of polydimethylsiloxane, 0.5 part of tocopherol acetate, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.1 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.1 part of isohexadecane, 600.1 parts of polysorbate, 0.1 part of sorbitan isostearate, 0.1 part of ceramide NS/ceramide NG, 0.1 part of cholesterol, 0.1 part of stearic acid, 0.1 part of polyglycerol-10 stearate, 0.1 part of allantoin, 0.1 part of bisabolol, 0.1 part of cycloxanthinol stilbene, 0.1 part of tetrandra root extract, 0.1 part of dipropylene glycol, 0.1 part of hydrogenated lecithin, 0.1 part of tremella polysaccharide, 0.1 part of tetrahydro-methyl pyrimidine carboxylic acid, 10.1 parts of tripeptide, 0.1 part of sodium hyaluronate, 0.1 part of dipeptide diaminobutyryl benzyl amide diacetate, 0.01 part of acetyl hexapeptide-80.01 part, 0.01 part of arginine/lysine polypeptide, 50.01 parts of acetyl tetrapeptide-10.01 parts of palmitoyl tripeptide, 50.005 parts of palmitoyl tripeptide, 70.005 parts of palmitoyl tetrapeptide, 40.005 parts of palmitoyl pentapeptide and purified water which are added to 100 parts.
A preparation method of the anti-aging cream comprises the following steps:
(1) dividing pentaerythritol tetra (ethyl hexanoate) ester, polyglycerol-10 distearate, hydrogenated polyisobutene, shea butter, glyceryl behenate/eicosanedioate, cetostearyl alcohol, polydimethylsiloxane, tocopheryl acetate, ceramide NS/ceramide NG, stearic acid, cholesterol, polyglycerol-10 stearate and hydrogenated lecithin into a group A, sequentially adding the group A into a pot, starting a heating button to heat, and stirring at the same time, wherein the stirring speed is 20 revolutions per minute;
(2) dividing hydroxypropyl tetrahydropyrane triol, allantoin and water into a group B, adding the group B into a pot, starting a heating button or a steam valve to heat, and stirring at the speed of 20 revolutions per minute;
(3) heating the group B pan to 95-100 ℃, heating the oil phase pan to 82-85 ℃, and simultaneously preserving heat and sterilizing for 30 minutes;
(4) opening a feeding valve of an emulsifying pot, pumping the raw materials of the group A and the group B in vacuum, starting stirring at the same time, keeping the temperature at 85 +/-2 ℃, stopping stirring after an oil-water phase is drained, starting a homogenizing button, homogenizing for 3 minutes at a homogenizing speed of 3000 revolutions per minute, finishing homogenizing, stirring for 5 minutes at a stirring speed of 40 revolutions per minute, homogenizing for 3 minutes again, and keeping the vacuum degree at-0.04 MPa to form a paste body;
(5) and opening a cooling water valve and a drain valve, cooling the paste to 70-75 ℃, and adding tremella polysaccharide, sodium hyaluronate and group C swelled with 15% of sterilizing water from an adding port: p-hydroxyacetophenone, 1, 2-hexanediol, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-60 and sorbitan isostearate, homogenizing for 1 minute at the homogenizing speed of 1000 revolutions per minute, continuously stirring at the stirring speed of 30 revolutions per minute, and keeping the vacuum degree at-0.04 MPa;
(6) continuously stirring at the stirring speed of 30 revolutions per minute, and performing vacuum degassing for 1-2 times according to the condition of the paste;
(7) opening a cooling water valve and a drain valve, cooling the paste to below 40 ℃, dissolving palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4 and cycloastragenol by using butanediol, adding the dissolved transparent paste into an emulsifying pot, stirring for 2 minutes, dissolving dipeptide diaminobutyrylbenzyl amide diacetate, tetrahydro-methyl pyrimidine carboxylic acid, tripeptide-1, acetyl tetrapeptide-5, acetyl hexapeptide-8 and arginine/lysine polypeptide by using reserved water, adding the dissolved solution into the pot, continuously stirring for 2 minutes, finally sequentially adding the rest of D-phase glycerol glucoside, glycerol, biogum-1, radix stephaniae tetrandrae extract, dipropylene glycol and bisabolol, continuously stirring at the stirring speed of 20 revolutions per minute, and keeping the vacuum degree of-0.04 MPa;
(8) cooling to below 32 ℃, stopping stirring, discharging vacuum, performing central control detection under the vacuum degree of 0MPa, and discharging;
(9) and (6) filling.
(III) advantageous effects
The invention provides anti-aging face cream. The method has the following beneficial effects:
according to the invention, cycloastragenol capable of activating telomerase, anti-aging hydroxypropyl tetrahydropyrane triol and other substances are selected and reasonably matched, and the prepared product has the effects of delaying aging and tightening skin.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
the embodiment of the invention provides anti-aging face cream which is prepared from the following raw materials in parts by weight: 4 parts of pentaerythritol tetra (ethyl hexanoate), 3 parts of butanediol, 3 parts of hydroxypropyl tetrahydropyrane triol, 1 part of glycerol glucoside, 1 part of glycerol, 1 part of polyglycerol-10 distearate, 11 parts of biogan gum, 1 part of hydrogenated polyisobutene, 1 part of shea butter, 0.5 part of glyceryl behenate, 0.5 part of cetostearyl alcohol, 0.5 part of polydimethylsiloxane, 0.5 part of tocopherol acetate, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.1 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.1 part of isohexadecane, 600.1 parts of polysorbate, 0.1 part of sorbitan isostearate, 0.1 part of ceramide NS/ceramide NG, 0.1 part of cholesterol, 0.1 part of stearic acid, 0.1 part of polyglycerol-10 stearate, 0.1 part of allantoin, 0.1 part of bisabolol, 0.1 part of cycloxanthinol stilbene, 0.1 part of tetrandra root extract, 0.1 part of dipropylene glycol, 0.1 part of hydrogenated lecithin, 0.1 part of tremella polysaccharide, 0.1 part of tetrahydro-methyl pyrimidine carboxylic acid, 10.1 parts of tripeptide, 0.1 part of sodium hyaluronate, 0.1 part of dipeptide diaminobutyryl benzyl amide diacetate, 0.01 part of acetyl hexapeptide-80.01 part, 0.01 part of arginine/lysine polypeptide, 50.01 parts of acetyl tetrapeptide-10.01 parts of palmitoyl tripeptide, 50.005 parts of palmitoyl tripeptide, 70.005 parts of palmitoyl tetrapeptide, 40.005 parts of palmitoyl pentapeptide and purified water which are added to 100 parts.
Wherein pentaerythritol tetra (ethyl hexanoate) ester, hydrogenated polyisobutene and shea butter are used as the emollient;
butanediol, biological carbohydrate gum-1, 2-hexanediol, allantoin, hydrogenated lecithin, Tremella polysaccharide, tetrahydro-methyl pyrimidine carboxylic acid, and sodium hyaluronate as humectant;
hydroxypropyl tetrahydropyrane triol and glycerol glucose, glycerose, ceramide NS/ceramide NG, stearic acid, cholesterol, bisabolol, cycloastragenol, tetrandrine extract, dipropylene glycol, tripeptide-1, dipeptide diaminobutyrylbenzylamide diacetate, acetyl hexapeptide-8, arginine/lysine polypeptide, acetyl tetrapeptide-5, palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, and palmitoyl pentapeptide-4 as skin conditioner;
polyglycerol-10 distearate, glyceryl behenate, cetearyl alcohol, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-60, sorbitan isostearate, and polyglycerol-10 stearate as emulsifiers;
polydimethylsiloxane as an antifoaming agent, and tocopherol acetate and p-hydroxyacetophenone as antioxidants.
The preparation method of the anti-aging cream comprises the following steps:
(1) dividing pentaerythritol tetra (ethyl hexanoate) ester, polyglycerol-10 distearate, hydrogenated polyisobutene, shea butter, glyceryl behenate/eicosanedioate, cetostearyl alcohol, polydimethylsiloxane, tocopheryl acetate, ceramide NS/ceramide NG, stearic acid, cholesterol, polyglycerol-10 stearate and hydrogenated lecithin into a group A, sequentially adding the group A into a pot, starting a heating button to heat, and stirring at the same time, wherein the stirring speed is 20 revolutions per minute;
(2) dividing hydroxypropyl tetrahydropyrane triol, allantoin and water into a group B, adding the group B into a pot, starting a heating button or a steam valve to heat, and stirring at the speed of 20 revolutions per minute;
(3) heating the group B pan to 95-100 ℃, heating the oil phase pan to 82-85 ℃, and simultaneously preserving heat and sterilizing for 30 minutes;
(4) opening a feeding valve of an emulsifying pot, pumping the raw materials of the group A and the group B in vacuum, starting stirring at the same time, keeping the temperature at 85 +/-2 ℃, stopping stirring after an oil-water phase is drained, starting a homogenizing button, homogenizing for 3 minutes at a homogenizing speed of 3000 revolutions per minute, finishing homogenizing, stirring for 5 minutes at a stirring speed of 40 revolutions per minute, homogenizing for 3 minutes again, and keeping the vacuum degree at-0.04 MPa to form a paste body;
(5) and opening a cooling water valve and a drain valve, cooling the paste to 70-75 ℃, and adding tremella polysaccharide, sodium hyaluronate and group C swelled with 15% of sterilizing water from an adding port: p-hydroxyacetophenone, 1, 2-hexanediol, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-60 and sorbitan isostearate, homogenizing for 1 minute at the homogenizing speed of 1000 revolutions per minute, continuously stirring at the stirring speed of 30 revolutions per minute, and keeping the vacuum degree at-0.04 MPa;
(6) continuously stirring at the stirring speed of 30 revolutions per minute, and performing vacuum degassing for 1-2 times according to the condition of the paste;
(7) opening a cooling water valve and a drain valve, cooling the paste to below 40 ℃, dissolving palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4 and cycloastragenol by using butanediol, adding the dissolved transparent paste into an emulsifying pot, stirring for 2 minutes, dissolving dipeptide diaminobutyrylbenzyl amide diacetate, tetrahydro-methyl pyrimidine carboxylic acid, tripeptide-1, acetyl tetrapeptide-5, acetyl hexapeptide-8 and arginine/lysine polypeptide by using reserved water, adding the dissolved solution into the pot, continuously stirring for 2 minutes, finally sequentially adding the rest of D-phase glycerol glucoside, glycerol, biogum-1, radix stephaniae tetrandrae extract, dipropylene glycol and bisabolol, continuously stirring at the stirring speed of 20 revolutions per minute, and keeping the vacuum degree of-0.04 MPa;
(8) cooling to below 32 ℃, stopping stirring, discharging vacuum, performing central control detection under the vacuum degree of 0MPa, and discharging;
(9) and (6) filling.
Example two:
the embodiment of the invention provides anti-aging face cream which is prepared from the following raw materials in parts by weight: pentaerythritol tetra (ethyl hexanoate) 3 parts, butanediol 2 parts, hydroxypropyl tetrahydropyran triol 2 parts, glycerol glucoside 0.5 part, glycerol 0.5 part, polyglycerol-10 distearate 0.5 part, biosaccharide-10.5 parts, hydrogenated polyisobutene 0.5 part, shea butter 0.5 part, glyceryl behenate 0.25 part, cetostearyl alcohol 0.25 part, polydimethylsiloxane 0.25 part, tocopheryl acetate 0.25 part, p-hydroxyacetophenone 0.25 part, 1, 2-hexanediol 0.25 part, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 0.05 part, isohexadecane 0.05 part, polysorbate-600.05 part, sorbitan isostearate 0.05 part, ceramide NS/ceramide NG 0.05 part, stearic acid 0.05 part, cholesterol 0.05 part, polyglycerol-10 stearate 0.05 part, allantoin 0.05 part, bisabolol 0.05 part, and flavonol 0.05 part, 0.05 part of tetrandra root extract, 0.05 part of dipropylene glycol, 0.05 part of hydrogenated lecithin, 0.05 part of tremella polysaccharide, 0.05 part of tetrahydro-methyl pyrimidine carboxylic acid, 10.05 parts of tripeptide, 0.05 part of sodium hyaluronate, 0.05 part of dipeptide diaminobutyryl benzyl amide diacetate, 80.005 parts of acetyl hexapeptide, 0.005 part of arginine/lysine polypeptide, 50.005 parts of acetyl tetrapeptide-10.005 parts of palmitoyl tripeptide-50.0025 parts of palmitoyl tetrapeptide-70.0025 parts of palmitoyl pentapeptide-40.0025 parts of palmitoyl pentapeptide and purified water which are supplemented to 100 parts.
The preparation method is the same as the first embodiment.
Example three:
the embodiment of the invention provides anti-aging face cream which is prepared from the following raw materials in parts by weight: pentaerythritol tetra (ethyl hexanoate) 5 parts, butanediol 4 parts, hydroxypropyl tetrahydropyran triol 4 parts, glycerol glucoside 1.5 parts, glycerol 1.5 parts, polyglycerol-10 distearate 1.5 parts, biosaccharide gum 11.5 parts, hydrogenated polyisobutene 1.5 parts, shea butter 1.5 parts, glyceryl behenate 0.75 part, cetostearyl alcohol 0.75 part, polydimethylsiloxane 0.75 part, tocopheryl acetate 0.75 part, p-hydroxyacetophenone 0.75 part, 1, 2-hexanediol 0.75 part, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer 0.15 part, isohexadecane 0.15 part, polysorbate-600.15 part, sorbitan isostearate 0.15 part, ceramide NS/ceramide NG 0.15 part, stearic acid 0.15 part, cholesterol 0.15 part, polyglycerol-10 stearate 0.15 part, allantoin 0.15 part, bisabolol 0.15 part, and xanthinol 0.15 part, 0.15 part of tetrandra root extract, 0.15 part of dipropylene glycol, 0.15 part of hydrogenated lecithin, 0.15 part of tremella polysaccharide, 0.15 part of tetrahydro-methyl pyrimidine carboxylic acid, 10.15 parts of tripeptide, 0.15 part of sodium hyaluronate, 0.15 part of dipeptide diaminobutyryl benzyl amide diacetate, 0. 80.015 part of acetyl hexapeptide, 0.015 part of arginine/lysine polypeptide, 50.015 parts of acetyl tetrapeptide, 10.015 parts of palmitoyl tripeptide, 50.0075 parts of palmitoyl tripeptide, 70.0075 parts of palmitoyl tetrapeptide-40.0075 parts and purified water which are added to 100 parts.
The preparation method is the same as the first embodiment.
Example four:
selecting 40 female healthy subjects with age of 35-60 years and skin color of II-IV type (Chardon grading method), preferably patients with loose skin and wrinkles around face/eyes; exclusion criteria: firstly, there is a history of skin care product allergy; ② one week or one month after the administration of antihistamines or immunosuppressants; ③ the patients who have participated in other facial clinical studies or treated by dermatologists within 3 months. After the subjects signed an informed consent, they were randomly divided into 4 groups of 10 persons each, using the product, receiving the test and completing the follow-up strictly following the study protocol.
After the face of the subject is cleaned in the morning and evening, a proper amount of sample is uniformly smeared on the whole face and is massaged until the sample is absorbed. The administration is performed 2 times daily for 12 weeks. Volunteers did not change the daily facial cleanser brand during the test. In the comparative example, a sample in which one or all of hydroxypropyl tetrahydropyrane triol, cycloastragenol were removed was used. The subjects followed 1 visit before (week 0) with the samples for each of 6 and 12 weeks, and measured values of each parameter index of the Skin were collected using a Skin moisture tester Corneometer CM825, a Skin gloss tester Skin-Glossymeter GL200, and a Skin elasticity tester Cutomermeter MPA580, respectively.
Moisture content of skin: measuring the moisture content of the cheek skin on one random side by using a skin moisture tester, continuously measuring for 5 times, taking an average value, wherein the value represents the moisture content, and the larger the value is, the more moist the skin is; conversely, the drier the skin.
Skin glossiness: the gloss of the skin of the cheek on one side of the random was measured using a skin gloss tester 5 times in succession and averaged. The larger the measurement, the more shiny the skin; conversely, the darker the skin.
Skin elasticity: the canthus on one side was measured randomly using a skin elasticity tester, continuously 3 times, and the average was taken. The parameter R2 is selected, R2 is Ua/Uf, Ua is the total resilience of the skin when the negative pressure is added on the surface of the skin continuously tested from the elimination of the negative pressure to the next time, Uf is the maximum stretching amount of the skin when the negative pressure exists, and the closer the R2 value is to 1, the better the skin elasticity is represented.
The skin condition of the subjects before (week 0) using the samples, at weeks 6 and 12 using the samples was scored as questionnaires, and evaluated from 0 point (poor) to 3 points (good) according to their subjective feeling (difference in skin aging resistance before and after using the samples), with evaluation criteria of i: no improvement (difference is less than or equal to 0 min); II: slightly improving (the difference is more than 0 min and less than or equal to 1 min); III: moderate improvement (1 point < difference less than or equal to 2 points); IV: obviously improved (the difference is more than 2 and less than or equal to 3 minutes).
Statistical analysis of the measurement data was performed using SPSS19.0 data analysis software. Using t-test, comparing the values of skin parameters collected at 0 weeks with 6 weeks, 12 weeks, P <0.05 is statistically significant.
Experimental results show that the anti-aging cream has good anti-aging effect. After the face cream is used, the moisture content of the horny layer of the skin is gradually increased, and the face cream has statistical significance after being used for 6 weeks; the skin glossiness is in an increasing trend and has statistical significance after being used for 6 weeks respectively; the value of the skin elasticity R2 of the canthus gradually rises, and has statistical significance from 6 weeks of use; subjective feeling evaluation results also show that the product has good anti-aging effect and has statistical significance after being used for 6 weeks; the examples are more effective than the comparative examples, which do not use cosmetics (specific data are shown in the following table).
In the table, the data in the examples are better than the comparative examples in effect, that is, the combination of hydroxypropyl tetrahydropyrane triol and cycloastragenol is used, and the prepared cream has the effects of resisting aging and tightening the skin.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (3)
1. The anti-aging cream is characterized by being prepared from the following raw materials in parts by weight: 3-5 parts of pentaerythritol tetra (ethyl hexanoate), 2-4 parts of butanediol, 2-4 parts of hydroxypropyl tetrahydropyran triol, 0.5-1.5 parts of glycerol glucoside, 0.5-1.5 parts of glycerol, 0.5-1.5 parts of polyglycerol-10 distearate, 10.5-1.5 parts of biogan gum, 0.5-1.5 parts of hydrogenated polyisobutene, 0.5-1.5 parts of shea butter, 0.25-0.75 part of glyceryl behenate, 0.25-0.75 part of cetearyl alcohol, 0.25-0.75 part of polydimethylsiloxane, 0.25-0.75 part of tocopheryl acetate, 0.25-0.75 part of p-hydroxyacetophenone, 0.25-0.75 part of 1, 2-hexanediol, 0.05-0.15 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.05-0.15 part of isohexadecane, 0.05-0.15 part of polysorbate, 0.15-3515 parts of sorbitan ester, 0.05-15 parts of ceramide, 0.05-15 parts of NS 0.05/15 parts of ceramide, 0.05-0.15 part of stearic acid, 0.05-0.15 part of cholesterol, 0.05-0.15 part of polyglycerol-10 stearate, 0.05-0.15 part of allantoin, 0.05-0.15 part of bisabolol, 0.05-0.15 part of cycloastragenol, 0.05-0.15 part of tetrandra root extract, 0.05-0.15 part of dipropylene glycol, 0.05-0.15 part of hydrogenated lecithin, 0.05-0.15 part of tremella polysaccharide, 0.05-0.15 part of tetrahydromethylpyrimidine carboxylic acid, 10.05-0.15 part of tripeptide-10.05, 0.05-0.15 part of sodium hyaluronate, 0.05-0.15 part of dipeptide diaminobutyryl benzylamide diacetate, 0.36-0.015 part of acetyl hexapeptide-80.005, 0.005-0.015 part of arginine/lysine polypeptide, 0.015-50.005 part of acetyl tetrapeptide-539 2, 0.015-10.005 part of palmitoyl tripeptide, 0.015-10.005 part of palmitoyl peptide, 0.0075-365-70.0025 parts of purified water, and 0.0075-100 parts of palmitoyl peptide.
2. The anti-aging cream according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 4 parts of pentaerythritol tetra (ethyl hexanoate), 3 parts of butanediol, 3 parts of hydroxypropyl tetrahydropyrane triol, 1 part of glycerol glucoside, 1 part of glycerol, 1 part of polyglycerol-10 distearate, 11 parts of biogan gum, 1 part of hydrogenated polyisobutene, 1 part of shea butter, 0.5 part of glyceryl behenate, 0.5 part of cetostearyl alcohol, 0.5 part of polydimethylsiloxane, 0.5 part of tocopherol acetate, 0.5 part of p-hydroxyacetophenone, 0.5 part of 1, 2-hexanediol, 0.1 part of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.1 part of isohexadecane, 600.1 parts of polysorbate, 0.1 part of sorbitan isostearate, 0.1 part of ceramide NS/ceramide NG, 0.1 part of cholesterol, 0.1 part of stearic acid, 0.1 part of polyglycerol-10 stearate, 0.1 part of allantoin, 0.1 part of bisabolol, 0.1 part of cycloxanthinol stilbene, 0.1 part of tetrandra root extract, 0.1 part of dipropylene glycol, 0.1 part of hydrogenated lecithin, 0.1 part of tremella polysaccharide, 0.1 part of tetrahydro-methyl pyrimidine carboxylic acid, 10.1 parts of tripeptide, 0.1 part of sodium hyaluronate, 0.1 part of dipeptide diaminobutyryl benzyl amide diacetate, 0.01 part of acetyl hexapeptide-80.01 part, 0.01 part of arginine/lysine polypeptide, 50.01 parts of acetyl tetrapeptide-10.01 parts of palmitoyl tripeptide, 50.005 parts of palmitoyl tripeptide, 70.005 parts of palmitoyl tetrapeptide, 40.005 parts of palmitoyl pentapeptide and purified water which are added to 100 parts.
3. The proposed preparation method of an anti-aging cream according to claims 1-2, characterized by comprising the following steps:
(1) dividing pentaerythritol tetra (ethyl hexanoate) ester, polyglycerol-10 distearate, hydrogenated polyisobutene, shea butter, glyceryl behenate/eicosanedioate, cetostearyl alcohol, polydimethylsiloxane, tocopheryl acetate, ceramide NS/ceramide NG, stearic acid, cholesterol, polyglycerol-10 stearate and hydrogenated lecithin into a group A, sequentially adding the group A into a pot, starting a heating button to heat, and stirring at the same time, wherein the stirring speed is 20 revolutions per minute;
(2) dividing hydroxypropyl tetrahydropyrane triol, allantoin and water into a group B, adding the group B into a pot, starting a heating button or a steam valve to heat, and stirring at the speed of 20 revolutions per minute;
(3) heating the group B pan to 95-100 ℃, heating the oil phase pan to 82-85 ℃, and simultaneously preserving heat and sterilizing for 30 minutes;
(4) opening a feeding valve of an emulsifying pot, pumping the raw materials of the group A and the group B in vacuum, starting stirring at the same time, keeping the temperature at 85 +/-2 ℃, stopping stirring after an oil-water phase is drained, starting a homogenizing button, homogenizing for 3 minutes at a homogenizing speed of 3000 revolutions per minute, finishing homogenizing, stirring for 5 minutes at a stirring speed of 40 revolutions per minute, homogenizing for 3 minutes again, and keeping the vacuum degree at-0.04 MPa to form a paste body;
(5) and opening a cooling water valve and a drain valve, cooling the paste to 70-75 ℃, and adding tremella polysaccharide, sodium hyaluronate and group C swelled with 15% of sterilizing water from an adding port: p-hydroxyacetophenone, 1, 2-hexanediol, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-60 and sorbitan isostearate, homogenizing for 1 minute at the homogenizing speed of 1000 revolutions per minute, continuously stirring at the stirring speed of 30 revolutions per minute, and keeping the vacuum degree at-0.04 MPa;
(6) continuously stirring at the stirring speed of 30 revolutions per minute, and performing vacuum degassing for 1-2 times according to the condition of the paste;
(7) opening a cooling water valve and a drain valve, cooling the paste to below 40 ℃, dissolving palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4 and cycloastragenol by using butanediol, adding the dissolved transparent paste into an emulsifying pot, stirring for 2 minutes, dissolving dipeptide diaminobutyrylbenzyl amide diacetate, tetrahydro-methyl pyrimidine carboxylic acid, tripeptide-1, acetyl tetrapeptide-5, acetyl hexapeptide-8 and arginine/lysine polypeptide by using reserved water, adding the dissolved solution into the pot, continuously stirring for 2 minutes, finally sequentially adding the rest of D-phase glycerol glucoside, glycerol, biogum-1, radix stephaniae tetrandrae extract, dipropylene glycol and bisabolol, continuously stirring at the stirring speed of 20 revolutions per minute, and keeping the vacuum degree of-0.04 MPa;
(8) cooling to below 32 ℃, stopping stirring, discharging vacuum, performing central control detection under the vacuum degree of 0MPa, and discharging;
(9) and (6) filling.
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| CN202111409737.5A CN114177104A (en) | 2021-11-25 | 2021-11-25 | Anti-aging face cream |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114917156A (en) * | 2022-05-16 | 2022-08-19 | 珠海市医健生物技术研发中心 | Composite anti-aging cold-blended skin cream and preparation method thereof |
| CN115089499A (en) * | 2022-05-20 | 2022-09-23 | 广州耀悦生物科技有限公司 | Mud film with space cage type structure and preparation method |
| CN115517987A (en) * | 2022-09-30 | 2022-12-27 | 菏泽牡丹产业技术研究院 | Multilayer moisturizing, repairing, wrinkle-removing and anti-aging peony face cream and preparation method thereof |
| CN115737515A (en) * | 2022-11-23 | 2023-03-07 | 四川肽美生物科技有限公司 | Skin anti-aging composition containing boscalid and psoralea fruit phenol and production process thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080057010A1 (en) * | 2006-09-01 | 2008-03-06 | Nuliv Science Ltd. | Method for skin care |
| CN110974743A (en) * | 2019-12-10 | 2020-04-10 | 武汉克鲁金生物科技有限公司 | Method for producing yeast cycloastragenol polypeptide mixed liquor and anti-aging application thereof |
| CN111789777A (en) * | 2020-08-15 | 2020-10-20 | 广州市珍榜日用化工有限公司 | Skin care cream with immediate tightening and anti-aging effects and preparation method thereof |
| CN112402310A (en) * | 2020-10-30 | 2021-02-26 | 广州市妆妍生物技术有限公司 | Vitreous chromogen polypeptide anti-wrinkle eye cream and preparation method thereof |
| US20210093539A1 (en) * | 2019-09-30 | 2021-04-01 | Concept Matrix Solutions | Topical cosmetic |
-
2021
- 2021-11-25 CN CN202111409737.5A patent/CN114177104A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080057010A1 (en) * | 2006-09-01 | 2008-03-06 | Nuliv Science Ltd. | Method for skin care |
| US20210093539A1 (en) * | 2019-09-30 | 2021-04-01 | Concept Matrix Solutions | Topical cosmetic |
| CN110974743A (en) * | 2019-12-10 | 2020-04-10 | 武汉克鲁金生物科技有限公司 | Method for producing yeast cycloastragenol polypeptide mixed liquor and anti-aging application thereof |
| CN111789777A (en) * | 2020-08-15 | 2020-10-20 | 广州市珍榜日用化工有限公司 | Skin care cream with immediate tightening and anti-aging effects and preparation method thereof |
| CN112402310A (en) * | 2020-10-30 | 2021-02-26 | 广州市妆妍生物技术有限公司 | Vitreous chromogen polypeptide anti-wrinkle eye cream and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| CHENG LEIYU，等: "Efficient production of the anti-aging drug Cycloastragenol: insight from two Glycosidases by enzyme mining", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 104, pages 9991 - 10004, XP037291905, DOI: 10.1007/s00253-020-10966-5 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114917156A (en) * | 2022-05-16 | 2022-08-19 | 珠海市医健生物技术研发中心 | Composite anti-aging cold-blended skin cream and preparation method thereof |
| CN115089499A (en) * | 2022-05-20 | 2022-09-23 | 广州耀悦生物科技有限公司 | Mud film with space cage type structure and preparation method |
| CN115517987A (en) * | 2022-09-30 | 2022-12-27 | 菏泽牡丹产业技术研究院 | Multilayer moisturizing, repairing, wrinkle-removing and anti-aging peony face cream and preparation method thereof |
| CN115737515A (en) * | 2022-11-23 | 2023-03-07 | 四川肽美生物科技有限公司 | Skin anti-aging composition containing boscalid and psoralea fruit phenol and production process thereof |
| CN116172891A (en) * | 2023-03-10 | 2023-05-30 | 珠海市华中源生物科技有限公司 | Multi-effect moisturizing composition and preparation method thereof |
| CN116172891B (en) * | 2023-03-10 | 2023-11-28 | 珠海市华中源生物科技有限公司 | Multi-effect moisturizing composition and preparation method thereof |
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