CN108578324A - A kind of skin cream and preparation method thereof with long-acting moisture-keeping efficacy - Google Patents

A kind of skin cream and preparation method thereof with long-acting moisture-keeping efficacy Download PDF

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CN108578324A
CN108578324A CN201810707166.5A CN201810707166A CN108578324A CN 108578324 A CN108578324 A CN 108578324A CN 201810707166 A CN201810707166 A CN 201810707166A CN 108578324 A CN108578324 A CN 108578324A
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long
skin cream
acting
moisturizing
skin
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唐万夫
李雪竹
章志强
刘海勇
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SHANGHAI NEW COGI COSMETIC Co Ltd
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SHANGHAI NEW COGI COSMETIC Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63Steroids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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  • Cosmetics (AREA)

Abstract

The invention discloses a kind of skin cream and preparation method thereof with long-acting moisture-keeping efficacy.By mass percentage, the skin cream is grouped as by the following raw material group:Long-acting moisturizing complexing agent 10 25%, solvent 55 75%, emulsifier 1 5%, moisturizing grease 10 30%, stabilizer 0.2 1.5%, pH adjusting agent 0.01 1%, skin conditioning agent 1 10%, preservative 0.1 1%, aromatic 0.03 0.5%.The skin cream of the present invention, feature are that the ingredient of moisturizing combination is:Echinacea angustifolia extract, Acer negundo extract, saccharomycete/rice fermentation Product filtrate, lauroyl dilactic acid sodium, Cer NP, Cer AP II, Cer EOS, phytosphingosine, phytosterol, carnosine, by optimizing the compounding and adding proportion of long-acting moisturizing complexing agent, there is the moistening effect up to 4 8h.

Description

A kind of skin cream and preparation method thereof with long-acting moisture-keeping efficacy
Technical field
The present invention relates to a kind of moisture surge treatment formula, belong to cosmetic technical field, and in particular to one kind having long-acting moisturizing Skin cream of effect and preparation method thereof.
Background technology
The content of moisture in skin, it is fine and smooth, glossy with skin, it is very crucial whether healthy.Using with moisturizing work( The skin cream of effect is that consumer keeps skin water tender, the important channel of appropriate moisturizing.The skin cream of current moisturizing class on the market, Category is numerous, and moistening effect is different, commonly uses the polyalcohols such as moisturizing ingredient such as glycerine, butanediol and trehalose, glucan, transparent Matter acid sodium etc. emulsifies gained in conjunction with moisturizing grease such as vaseline, caprylic/capric triglyceride, isononyl isononanoate etc., is used in skin Because not high with Stratum corneum lipids double-layer structure compatibility on skin, it is unfavorable for the infiltration and conduction of active material so that skin cannot Higher water content is kept for a long time.
How a kind of skin cream skin-protection product with long-acting moisture-keeping efficacy is developed, to meet the various need in market It asks, is that those skilled in the art are badly in need of the technical barrier solved.
Invention content
The object of the present invention is to provide a kind of skin cream with long-acting moistening effect, moisturizing is combined in water, oil sources Property aspect take into account enhancing skin barrier function, and combine outside skin inside the sebum film to skin epidermis of cuticula high-moisture The increase of water content, plays a positive role.
The present invention also provides a kind of preparation methods of the above-mentioned skin cream with long-acting moistening effect.
To solve the above problems, the present invention uses following technical scheme:
A kind of skin cream with long-acting moisture-keeping efficacy contains long-acting moisturizing complexing agent in the skin cream, by quality hundred Divide than meter, the long-acting moisturizing complexing agent is made of following components:
As priority, by mass percentage, the long-acting moisturizing complexing agent is made of following components:
The skin cream also contains other raw materials, including solvent, emulsifier, moisturizing grease, stabilizer, pH adjusting agent, anti- Rotten agent, aromatic, by mass percentage, the skin cream are made of following raw material components:
Preferably, by mass percentage, the skin cream is made of following raw material components:
Furthermore, the solvent of the skin cream is selected from water, glycerine, butanediol, 1,3-PD, dipropylene glycol, gathers Any or their mixture in glycerin ether -26.
The emulsifier be selected from cetearyl glucoside, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, It is stearine, PEG-100 stearates, C20-22 alcohol phosphate, PEG-40 stearates, Sucrose myristate, sweet Oleostearin acid esters citrate, one kind in polyglycereol-3-methyl distearate or their mixture;
The moisturizing grease is selected from saualane, isooctadecanol isostearate, isohexadecane, avocado (PERSEA GRATISSIMA) oil, pentaerythrite four (thylhexoic acid) ester, octyl polymethyl siloxane, Nexbase 2004, the different nonyl of isononanoic acid Ester, caprylic/capric triglyceride, Jojoba (SIMMONDSIA CHINENSIS) seed oil, sad Propylheptyl, hexamethylene silica Alkane, cetanol, olive (OLEA EUROPAEA) fruit oil, docosyl alcohol, C10-18 resin acids triglyceride, polydimethylsiloxanes Alkane, one kind in Queensland nut (MACADAMIA TERNIFOLIA) seed oil or their mixture;
The stabilizer is selected from carbomer, xanthans, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymerics Object, ammonium acryloyl taurate/VP copolymer, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, propylene One kind in acyl dimethyltaurine ammonium/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers or their mixture;
The pH adjusting agent is selected from citric acid, sodium citrate, sodium hydroxide, triethanolamine, aminomethyl propanol, tromethamine In one kind or their mixture;
The skin conditioning agent is selected from trehalose, panthenol, glycine betaine, Sodium Hyaluronate, oat (AVENA SATIVA) β- Glucan, α-mannosan, chitosan, biological carbohydrate gum -1, levulan, xylitol or their mixture;
It is sweet that the preservative is selected from methyl hydroxybenzoate, Nipasol, dehydroactic acid sodium, potassium sorbate, sodium benzoate, chlorobenzene Ether, Phenoxyethanol;
The aromatic is selected from containing the few plant flowers fruity of anaphylactogen.
In addition, the present invention also provides the preparation methods of the above-mentioned skin cream with long-acting moisture-keeping efficacy, including walk as follows Suddenly:
1) the A item components of 56-70% by mass percentage, are weighed:Solvent, stabilizer, skin conditioning agent are stirred It is even;
2) the B item components of 15-25% by mass percentage, are weighed:Emulsifier, moisturizing grease, for use;
3) the C item components of 12.5-18% by mass percentage, are weighed:PH conditioning agents, long-acting moisturizing complexing agent, for use;
4) the D item components of 0.3-1.15% by mass percentage, are weighed:Preservative, aromatic, for use;
5) A components are heated to 80-85 DEG C, insulated and stirred is pumped into homogenizer, 5 points of homogeneous (2500rpm) after 30 minutes Clock stirs 5 minutes, heat preservation defoaming;
6) B components are heated to 80-85 DEG C, melt complete, addition homogenizer, homogeneous (3000rpm) 5 minutes, stirring 5 Minute, cooling;
7) 45 DEG C are cooled to, C components, D components are added, are stirred until homogeneous.
The A component:Water (To 100%), glycerine (5%), butanediol (3%), beta glucan (2%), carbomer (0.1%), xanthans (0.1%), methyl hydroxybenzoate (0.2%);
The B component:Coco group glucoside (2%), three (thylhexoic acid) ester of cetostearyl alcohol (1.5%) glycerine (5%), dimethyl silicone polymer (0.8%), isononyl isononanoate (4%), ring five dimethyl silicone polymer (3%), Australia are hard Fruit (MACADAMIA TERNIFOLIA) seed oil (1%), jojoba seed oil (1%);
The C component:Triethanolamine (0.1%), Echinacea angustifolia extract (0.8%), Acer negundo extract (1.2%), Saccharomycete/rice fermentation Product filtrate (0.92%), Cer NP (0.16%), Cer AP II (0.08%), neural acyl Amine 1 (0.08%), lauroyl dilactic acid sodium (0.6%), phytosphingosine (0.08%), phytosterol (0.08%), carnosine (0.24%);
The D component:Phenoxyethanol (0.4%), Nipasol 0.1%, essence (0.06%).
The property of important source material used in the present invention is as follows:
Purple coneflower (ECHINACEA PURPUREA) extract (SymFinity1298/Symrise):100% is natural, Fresh plant source, dry concentration extraction, contained Cichoric acid can effectively improve SIRT1 (deacetylase) activity, play Its cell ageing apoptosis participated in, sugared lipid metabolism, the reaction of inflammation oxidation emergency etc. are to the adjusting function of gene, in antioxygen Change, promote hyaluronic acid generation etc. plays the role of controling in moisturizing.
Acer negundo (ACER SACCHARUM) extract (Maple Water/ICHIMARU):It is derived from Quebec, Canada portion The Normal juice (age of tree 40 years or more, tree-walk 20CM or more) of region-by-region sugar maple tree trunk, rich in polysaccharide, Ca, K, Mg, Mn, malic acid, Promote fibroblast proliferation, so as to improve cell water content, skin transepidermal water loss, water content of stratum corneum is improved, in skin Outermost layer --- enhance skin barrier function in terms of the water of cuticula.
Saccharomycete/rice fermentation Product filtrate (ferment filtrate FC01/ Angel Yeasts):It is selected originate from 30 ° of longevities of north latitude it The organic glutinous rice in Zhongxiang City of township, ferments through unartificial yeast, containing abundant oligosaccharides, organic acid (tartaric acid), amino acid, small-molecule peptide Deng can enter skin corium quickly through cutin lamellar spacing, promote fibroblastic activity and collagen, elastic fibers and thoroughly Bright matter acid hyperplasia, active cell film water channel protein, endogenous increase the water content of skin.
Cer NP, Cer AP II, Cer EOS (SK-influx/Evonik):From tonka bean, through yeast The biotechnology production of bacterium fermentation, therefrom selects the double-deck stereo of chemical constitution and naturally occurring ceramide in human skin The consistent configuration of chemical constitution forms lipid backbone, affine with Stratum corneum lipids height, to enhance skin screen in terms of lipid Hinder function, the more conducively transmission of moisture and active matter.
Phytosterol (CardioAid/ADM):Have a very high osmosis to skin, increase lipase active, have adjust and The ability of reversed membrane fluidity is controlled, skin surface moisture can be kept.
Carnosine (Dragosine/Symrise):High-purity prevents glycosylation, promotes collagen synthesis, prevents from wrinkling The generation of line and the loss of elastin laminin, prevent oxidative damage, ROS scavengers, chelating metal ion, protection Skin Cell due to DNA damage caused by ultraviolet light.
The beneficial effects of the present invention are:
1) skin cream of the invention, the ingredient that moisturizing is combined are:Echinacea angustifolia extract, Acer negundo extract, saccharomycete/big Rice tunning filtrate, lauroyl dilactic acid sodium, Cer NP, Cer AP II, Cer EOS, phytosphingosine, plant Object sterol, carnosine have the moistening effect up to 4-8h by optimizing the compounding and adding proportion of long-acting moisturizing complexing agent.
2) skin cream of the invention, stresses fat-soluble, takes into account moisturizing combination and reaches oil-water balance, enhances skin barrier work( Can, and by endogenous increase water content to whole regulation and control, control, performance central role.
3) technical program of the present invention lies in, as a whole, the addition of solvent and moisturizing lubricant component, in conjunction with moisturizing Combine the lipid backbone that ceramide is formed, form bilayer lipid membrane, it is high with skin bilayer lipid membrane compatibility, be conducive to moisture and Active material infiltration, conveying enhance skin barrier function to improve moisture content of skin from inside to outside, and long-acting moisturizing is brought to imitate Fruit.
Specific implementation mode
Below by specific preferred embodiment combination effete test embodiment, technical scheme of the present invention is made further specific Illustrate, but the present invention is not limited in following embodiment.
A kind of moisturizing cream composition with long-acting moisture-keeping efficacy disclosed by the invention is pressed containing long-acting moisturizing complexing agent Mass percent meter, the long-acting moisturizing complexing agent include:The Acer negundo extraction of the Echinacea angustifolia extract, 20-40% of 15-30% Object, saccharomycete/rice fermentation Product filtrate of 15-30%, the Cer NP of 0.5-5%, 0.5-5% Cer AP II, The plant of the Cer EOS of 0.5-5%, lauroyl the dilactic acid sodium, the phytosphingosine of 0.5-5%, 0.5-5% of 10-20% The carnosine of object sterol, 0.1-0.3%.The skin cream of the present invention, by optimizing the compounding and adding proportion of long-acting moisturizing complexing agent, With the moistening effect up to 4-8h.
Embodiment 1
A kind of skin cream with long-acting moisture-keeping efficacy, by mass percentage, the skin cream are by following raw material group Divide and constitutes:
A components:Water to100%, glycerine 3%, butanediol 5%, glycine betaine 1%, Sodium Hyaluronate 0.03%, carbomer 0.18%, methyl hydroxybenzoate 0.15%;
B components:The smooth olive oleate 0.5% of cetostearyl alcohol olive oleate 1%, sorb, saualane 4%, octyl Polymethyl siloxane 1%, isononyl isononanoate 3%, ring five dimethyl silicone polymer 2%, C10-18 resin acid triglycerides 0.5%;
C components:Aminomethyl propanol 0.1%, long-acting moisturizing complexing agent 12.0% (Echinacea angustifolia extract 2.58%, sugar Maple extract 4.5%, saccharomycete/rice fermentation Product filtrate 2.4%, Cer NP 0.06%, Cer AP II0.12%, Cer EOS 0.06%, lauroyl dilactic acid sodium 1.8%, phytosphingosine 0.24%, phytosterol 0.24%, carnosine 0.01%);
D components:Phenoxyethanol 0.4%, Nipasol 0.1%, essence 0.08%.
The preparation method of the above-mentioned moisturizing cream composition with long-acting moisture-keeping efficacy, includes the following steps:
1) A components by mass percentage, are weighed:Solvent (water, glycerine, butanediol), thickener (carbomer), stirring are mixed It closes uniform;
2) B components by mass percentage, are weighed:Emulsifier (the smooth olive oleic acid of cetostearyl alcohol olive oleate, sorb Ester), moisturizing grease (saualane, octyl polymethyl siloxane, isononyl isononanoate, ring five dimethyl silicone polymer, C10-18 fat Acid glycerol three ester class), for use;
3) C components by mass percentage, are weighed:PH adjusting agent (aminomethyl propanol), long-acting moisturizing complexing agent (purple pine nut Chrysanthemum extract, Acer negundo extract, saccharomycete/rice fermentation Product filtrate, Cer NP, Cer AP II, Cer EOS, Lauroyl dilactic acid sodium, phytosphingosine, phytosterol, carnosine), for use;
4) D components by mass percentage, are weighed:Preservative (Phenoxyethanol, Nipasol), aromatic (essence)
5) A components are heated to 80-85 DEG C, insulated and stirred cools down after 30 minutes;
6) 45 DEG C are cooled to, B components, C components are added, are stirred until homogeneous.
Embodiment 2
A kind of skin cream with long-acting moisture-keeping efficacy, by mass percentage, the skin cream are by following raw material group Divide and constitutes:
A components:Water to100%, glycerine 3%, 1,3- propylene glycol 5%, trehalose 1%, Sodium Hyaluronate 0.02%, Huang Virgin rubber 0.05%, biological carbohydrate gum -1 0.5%, ammonium acryloyldime-thyltaurate/- 25 methacrylate of docosyl alcohol polyethers 0.5%;
B components:C12-20 alkyl glucosides 1.5%, stearine 0.3%, glycerine three (thylhexoic acid) ester 5%, dimethyl silicone polymer 1%, sad Propylheptyl 3%, ring five dimethyl silicone polymer 3%, Jojoba (SIMMONDSIA CHINENSIS) seed oil;
C components:Citric acid 0.04, sodium citrate 0.01%, long-acting 15.0% (Echinacea angustifolia extract of moisturizing complexing agent 3.825%, Acer negundo extract 3.95%, saccharomycete/rice fermentation Product filtrate 3.85%, Cer NP 0.15%, nerve Amide 6II 0.15%, Cer EOS 0.075%, lauroyl dilactic acid sodium 2.25%, phytosphingosine 0.45%, plant Sterol 0.3%, carnosine 0.02%);
D components:Potassium sorbate 0.2%, Phenoxyethanol 0.4%, essence 0.1%.
The moisturizing cream composition preparation method with long-acting moisture-keeping efficacy of the present embodiment is the same as embodiment 1.
Embodiment 3
A kind of skin cream with long-acting moisture-keeping efficacy, by mass percentage, the skin cream are by following raw material group Divide and constitutes:
A:Water to100%, glycerine 3, polyglyceryl ether -26 2%, beta glucan 0.5%, chitosan 0.1%, Huang Virgin rubber 0.08%, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1%, methyl hydroxybenzoate 0.15%;
B:Surfhope SE Cosme C 1216 1.%, stearine 0.3%, avocado (PERSEA GRATISSIMA) oil 4%, PEG-100 stearates 0.7%, dimethyl silicone polymer 1.2%, sad Propylheptyl 3%, caprylic/capric triglyceride 3%, Nipasol 0.1%;
C:Triethanolamine 0.1%, long-acting moisturizing complexing agent 18.0% (Echinacea angustifolia extract 4.25%, Acer negundo extract 5.6%, saccharomycete/rice fermentation Product filtrate 4.23%, Cer NP 0.27%, Cer AP II 0.27%, nerve Amide 1 0.14%, lauroyl dilactic acid sodium 2.7%, phytosphingosine 0.36%, phytosterol 0.18%, carnosine 0.1%);
D:Phenoxyethanol 0.4%, Chlorphenesin 0.1%, essence 0.12%.
The moisturizing cream composition preparation method with long-acting moisture-keeping efficacy of the present embodiment is the same as embodiment 1.
Embodiment 4
A kind of skin cream with long-acting moisture-keeping efficacy, by mass percentage, the skin cream are by following raw material group Divide and constitutes:
A:Water to100%, glycerine 4%, propylene glycol 4%, α-mannosan 2%, xylitol 0.2%, hydroxy-ethyl acrylate/ Sodium acryloyldimethyl taurate copolymers 0.7%;
B:C20-22 alcohol phosphate 2%, glycerine three (thylhexoic acid) ester 5%, cetostearyl alcohol 2%, polydimethylsiloxanes Different 4% ester of nonyl of alkane 0.8%, isononanoic acid, ring five dimethyl silicone polymer 3%, Queensland nut (MACADAMIA TERNIFOLIA) Seed oil 2%;
C:Sodium hydroxide 0.12%, citric acid 0.04%, long-acting moisturizing complexing agent 20% (Echinacea angustifolia extract 5.0%, Acer negundo extract 6.1%, saccharomycete/rice fermentation Product filtrate 3.6%, Cer NP 0.4%, Cer AP II0.4%, Cer EOS 0.2%, lauroyl dilactic acid sodium 3.0%, phytosphingosine 1.0%, phytosterol 0.3%, Carnosine 0.3%);
D:Sodium benzoate 0.2%, Phenoxyethanol 0.4%, essence 0.15%.
The moisturizing cream composition preparation method with long-acting moisture-keeping efficacy of the present embodiment is the same as embodiment 1.
Control group:
Certain commercially available skin cream K sample without long-acting moisturizing complexing agent
Effect experimental examples
1, effect example:Security test
30 volunteers are chosen, in enclosed type patch test method, by each embodiment tested material about 0.020- of 1-4 of the present invention 0.025mL and blank control group (deionized water) are placed in spot examination device, and external application medical adhesive tape is pasted on subject or so back, Remove tested material after 24 hours, after removing patch 0.5h, for 24 hours, 48h observe dermoreaction, press《Cosmetics safety technology Specification》Dermoreaction grade scale records its result in (version in 2015).
Compared with the control group, product 0.5h of the present invention, for 24 hours, after 48h, have no rubefaction or the allergy such as erythema occur is applied Phenomenon illustrates that skin cream made from various embodiments of the present invention is safe, does not cause any bad phenomenon:
Table 1:Cosmetics human skin enclosed type patch experimental result
2, effect example:Moistening effect tests (8 hours)
With example formulations sample and control group, refer to reference to the evaluation of professional standard QB/T 4256-2011 cosmetics moisture-keeping efficacies South measures keratoderma hydration content and instrument using instrument MOISTUREMETERSC MSC1212 (DELFIN) TAPOMETER SWL5167 (DELFIN) measure transepidermal water loss rate score, measure respectively using 0h, 0.5h after sample, 1h, 2h, The numerical value of five periods of 4h, 8h records data, obtains a result, see Tables 1 and 2:
2 keratoderma hydration content of table changes (a.u)
Time Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Control group K
0h 30.24 31.25 30.18 31.32 32.29
0.5h 60.61 65.17 65.56 67.87 43.64
1h 64.37 72.28 78.34 83.12 51.82
2h 71.38 87.32 89.73 94.46 61.48
4h 57.95 70.17 75.55 79.58 38.63
8h 52.62 60.57 64.82 69.23 33.76
The percutaneous water loss rate (g/m of 3 skin of table2h)
Time Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Control group K
0h 4.23 4.42 4.83 4.67 4.53
0.5h 3.95 3.27 3.18 3.02 3.83
1h 3.86 3.72 3.65 3.57 3.42
2h 2.57 2.36 2.19 2.03 2.75
4h 3.87 3.63 3.48 3.32 4.06
8h 4.16 4.09 3.92 3.70 4.21
As shown in Table 2:1-4 of the embodiment of the present invention and control group K, after using sample 0.5-2h, skin keratin Layer hydration content has different degrees of promotion.After using 2h, keratoderma hydration contains wherein embodiment 3 and embodiment 4 It measures and reaches maximum value, respectively 89.73 and 94.46, compared with the maximum value 61.48 of control group K, there is significant difference.In addition, Control group K is using after 4-8h, and keratoderma hydration content is already close to initial value, and various embodiments of the present invention, by 4- After 8h tests, higher keratoderma hydration content is still maintained, illustrates various embodiments of the present invention, by optimizing long-acting guarantor The compounding and adding proportion of wet complexing agent have better more efficient moistening effect.
From the result of table 3 can with it is further seen that:Compared with control group K, 2-4 of the embodiment of the present invention is using 0.5-2h Afterwards, the percutaneous water loss rate of skin reduces more notable.After using 4-8h, the percutaneous water loss rate of control group K skins is Close to initial level, illustrate that control group K does not have long-acting moistening effect.And various embodiments of the present invention are still protected after 4-8h The percutaneous water loss rate of lower skin is hold, this further illustrates the present invention each embodiment, is adding long-acting moisturizing complexing agent And after optimizing adding proportion, there is more long-acting water retention property.
The above described is only a preferred embodiment of the present invention, consider formulation cost, preferred embodiment 2 and implementation Example 3, but be not intended to limit the present invention in any form, therefore it is every without departing from technical solution of the present invention content, according to this hair Bright technical spirit still falls within the technology of the present invention to any simple modification, equivalent change and modification made by above example In the range of scheme.

Claims (8)

1. a kind of skin cream with long-acting moisture-keeping efficacy, it is characterised in that:Contain long-acting moisturizing complexing agent in the skin cream, By mass percentage, the long-acting moisturizing complexing agent is made of following components:
2. the skin cream according to claim 1 with long-acting moisture-keeping efficacy, it is characterised in that:The skin cream contains length Moisturizing complexing agent is imitated, by mass percentage, the long-acting moisturizing complexing agent is made of following components:
3. the skin cream with long-acting moisture-keeping efficacy according to claim 1-2, it is characterised in that:The skin cream also contains It includes solvent, emulsifier, moisturizing grease, stabilizer, pH adjusting agent, preservative, fragrance to have other raw materials, other described raw materials Agent, by mass percentage, the skin cream are made of following raw material components:
4. the skin cream according to claim 3 with long-acting moisture-keeping efficacy, it is characterised in that:By mass percentage, The skin cream is made of following raw material components:
5. the skin cream with long-acting moisture-keeping efficacy according to any one of claim 1-4, it is characterised in that:It is described molten The one kind or their mixture of agent in water, glycerine, butanediol, 1,3- propylene glycol, dipropylene glycol, polyglyceryl ether -26;
The emulsifier is selected from cetearyl glucoside, cetostearyl alcohol olive oleate, the smooth olive oleate of sorb, glycerine Stearate, PEG-100 stearates, C20-22 alcohol phosphate, PEG-40 stearates, Sucrose myristate, glycerine are hard Resin acid ester citrate, one kind in polyglycereol-3-methyl distearate or their mixture;
The moisturizing grease is selected from saualane, isooctadecanol isostearate, isohexadecane, avocado (PERSEA GRATISSIMA) oil, pentaerythrite four (thylhexoic acid) ester, octyl polymethyl siloxane, Nexbase 2004, the different nonyl of isononanoic acid Ester, caprylic/capric triglyceride, Jojoba (SIMMONDSIA CHINENSIS) seed oil, sad Propylheptyl, hexamethylene silica Alkane, cetanol, olive (OLEA EUROPAEA) fruit oil, docosyl alcohol, C10-18 resin acids triglyceride, polydimethylsiloxanes Alkane, one kind in Queensland nut (MACADAMIA TERNIFOLIA) seed oil or their mixture;
The stabilizer is selected from carbomer, xanthans, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, third Alkene acyl dimethyltaurine ammonium/VP copolymers, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, acryloyl two One kind in N-methyltaurine ammonium/- 25 Methacrylate Crosspolymer of docosyl alcohol polyethers or their mixture;
The pH adjusting agent is in citric acid, sodium citrate, sodium hydroxide, triethanolamine, aminomethyl propanol, tromethamine A kind of or their mixture;
The skin conditioning agent is poly- selected from trehalose, panthenol, glycine betaine, Sodium Hyaluronate, the β-Portugal oat (AVENA SATIVA) Sugar, α-mannosan, chitosan, biological carbohydrate gum -1, levulan, xylitol or their mixture;
The preservative is selected from methyl hydroxybenzoate, Nipasol, dehydroactic acid sodium, potassium sorbate, sodium benzoate, Chlorphenesin, benzene Oxyethanol;
The aromatic is selected from containing the few plant flowers fruity of anaphylactogen.
6. the skin cream according to claim 5 with long-acting moisture-keeping efficacy, it is characterised in that:The pH adjusting agent control Between the pH of skin cream ranging from 5.5-6.5.
7. the preparation method of the skin cream with long-acting moisture-keeping efficacy described in claim 5, which is characterized in that including walking as follows Suddenly:
1) the A item components of 56-65% by mass percentage, are weighed:Solvent, stabilizer, skin conditioning agent, are uniformly mixed;
2) the B item components of 11-30% by mass percentage, are weighed:Emulsifier, moisturizing grease, for use;
3) the C item components of 15.5-21% by mass percentage, are weighed:PH conditioning agents, long-acting moisturizing complexing agent, for use;
4) the D item components of 0.25-1.3% by mass percentage, are weighed:Preservative, aromatic, for use;
5) A components being heated to 80-85 DEG C, insulated and stirred is after 30 minutes, suction homogenizer, homogeneous (2500rpm) 5 minutes, Stirring 5 minutes, heat preservation defoaming;
6) B components are heated to 80-85 DEG C, melt complete, addition homogenizer, homogeneous (3000rpm) 5 minutes, 5 points of stirring Clock, cooling;
7) 45 DEG C are cooled to, C components, D components are added, are stirred until homogeneous.
8. the preparation method of the skin cream according to claim 7 with long-acting moisture-keeping efficacy, it is characterised in that:
The A component:Water (To 100%), glycerine (5%), butanediol (3%), beta glucan (2%), carbomer (0.1%), xanthans (0.1%), methyl hydroxybenzoate (0.2%);
The B component:Coco group glucoside (2%), gathers three (thylhexoic acid) ester (5%) of cetostearyl alcohol (1.5%) glycerine Dimethyl siloxane (0.8%), isononyl isononanoate (4%), ring five dimethyl silicone polymer (3%), Queensland nut (MACADAMIA TERNIFOLIA) seed oil (1%), jojoba seed oil (1%);
The C component:Triethanolamine (0.1%), Echinacea angustifolia extract (0.8%), Acer negundo extract (1.2%), yeast Bacterium/rice fermentation Product filtrate (0.92%), Cer NP (0.16%), Cer AP II (0.08%), Cer EOS (0.08%), lauroyl dilactic acid sodium (0.6%), phytosphingosine (0.08%), phytosterol (0.08%), carnosine (0.24%);
The D component:Phenoxyethanol (0.4%), Nipasol 0.1%, essence (0.06%).
CN201810707166.5A 2018-07-02 2018-07-02 A kind of skin cream and preparation method thereof with long-acting moisture-keeping efficacy Pending CN108578324A (en)

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Application publication date: 20180928