CN114432207A - Long-acting moisturizing repair composition, repair cream and preparation method thereof - Google Patents
Long-acting moisturizing repair composition, repair cream and preparation method thereof Download PDFInfo
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Abstract
The invention provides a long-acting moisturizing repair composition, repair cream and a preparation method thereof, and relates to the technical field of daily chemicals. The long-acting moisturizing repair composition provided by the invention comprises the following components in parts by weight: 2.5-12 parts of emulsifier, 0.4-6 parts of skin repair additive and 0.03-2 parts of anti-allergy additive. According to the invention, the emulsifier, the skin repair additive and the anti-allergy additive of specific types are compounded in a specific proportion to form a composition system, and the components synergistically play a lasting moisturizing function, can assist in skin barrier repair, and can reduce the problems of dry peeling, red and itchy skin and fragile and sensitive skin of infants.
Description
Technical Field
The invention relates to the technical field of daily chemicals, and particularly relates to a long-acting moisturizing repair composition, a repair cream and a preparation method thereof.
Background
Among people who use skin care products, infants are a special group, the skin of the infants is tender and thinner than adults, and the skin of the infants is easier to absorb the skin care products, but the skin has poor acid-base control capability, the immune system of the skin is not perfect, the resistance is weak, the resistance to external environment irritation is low, the skin is easily damaged mechanically, the skin is easy to be allergic and is easy to infect skin diseases, and therefore the skin problems of dry peeling, red and itchy skin, fragility and sensitivity are more easily faced.
The market has greater and greater demands for the special mild and non-irritant moisturizing cream for infants, but the existing infant moisturizing cream still has a plurality of problems, such as high irritation (containing an acid-base regulator with high irritation, an organic solvent with high toxicity and the like), poor and non-lasting moisturizing effect, and is not beneficial to the healthy growth of the skin of the infant; the product has single function and can not effectively achieve the functions of water locking, moisture preservation and skin barrier repair. Therefore, the market needs to research infant moisturizing cream products which are safe, good in moisturizing effect, strong in moisturizing degree and free of greasiness.
Disclosure of Invention
In order to solve the problems in the prior art, the invention mainly aims to provide a long-acting moisturizing repair composition, a repair cream and a preparation method thereof.
In order to achieve the above purpose, in a first aspect, the present invention provides a long-acting moisturizing repair composition, which comprises the following components in parts by weight: 2.5-12 parts of emulsifier, 0.4-6 parts of skin repair additive and 0.03-2 parts of anti-allergy additive, wherein the emulsifier is composed of C10-18 fatty acid triglycerides, C20-22 alcohol phosphate and C20-22 alcohol, the skin repair additive is composed of ceramide NP, phytosterol and linoleic acid, and the anti-allergy additive is gentian root extract.
In the technical scheme of the invention, an emulsifier system consisting of C10-18 fatty acid triglycerides, C20-22 alcohol phosphate and C20-22 alcohol has super-strong moisturizing effect and good emulsifying capacity, is easy to form a liquid crystal structure, and has elegant texture, soft touch and velvet-like soft smooth feeling. The skin repair additive consisting of ceramide NP, phytosterol and linoleic acid has good repair and nourishing effects. The gentian root extract is used as a plant soothing component and is suitable for various people with sensitive muscles.
Through a large number of experiments, the inventor finds that a composition system formed by compounding the components can play a lasting moisturizing function, can assist in repairing skin barriers and can reduce the problems of dry and skinned skin, red and itchy skin and fragile and sensitive skin of infants.
As a preferred embodiment of the long-acting moisturizing repair composition, the emulsifier is composed of 1-6 parts by weight of C10-18 fatty acid triglyceride, 1.2-4.8 parts by weight of C20-22 alcohol phosphate and 0.3-1.2 parts by weight of C20-22 alcohol; the skin repair additive consists of 0.2-3 parts of ceramide NP, 0.1-1.5 parts of phytosterol and 0.1-1.5 parts of linoleic acid.
Through a large number of experiments, the inventor finds that the moisturizing and barrier repair effects of the composition system can be further improved by optimizing the dosage of each component within the range.
As a preferred embodiment of the long-acting moisturizing repair composition, the emulsifier is composed of 3-4 parts of C10-18 fatty acid triglyceride, 2-3 parts of C20-22 alcohol phosphate and 0.5-1 part of C20-22 alcohol in parts by weight; the skin repair additive consists of 0.5-1.5 parts of ceramide NP, 0.2-1 part of phytosterol and 0.2-1 part of linoleic acid.
As a preferred embodiment of the long-acting moisturizing repair composition of the present invention, in the skin repair additive, the weight ratio of the ceramide NP, the phytosterol and the linoleic acid is ceramide NP: phytosterols: linoleic acid 2:1: 1.
In the skin repair additive, when the weight ratio of the ceramide NP to the phytosterol to the linoleic acid is 2:1:1, the composition is closer to the skin of an infant, and can better exert the effects of good absorption and barrier function establishment.
In a second aspect, the present invention also provides a repair cream comprising the long-lasting moisturizing repair composition according to any one of the above.
As a preferred embodiment of the repair cream of the present invention, the repair cream further comprises at least one of a solvent, a thickener, a preservative synergist, a chelating agent, a humectant, an emollient, a co-emulsifier, and an efficacy additive.
As a preferred embodiment of the repair cream, the repair cream further comprises the following components in parts by weight: 10 to 100 portions of solvent, 0.02 to 0.35 portion of thickening agent, 0.2 to 0.8 portion of antiseptic synergist, 0.01 to 0.12 portion of chelating agent, 3.5 to 20 portions of humectant, 5 to 25 portions of emollient, 0.4 to 5 portions of emulsifying aid and 0.15 to 0.7 portion of efficacy additive.
As a preferred embodiment of the repair cream of the present invention, at least one of the following (a) to (h) is included:
(a) the solvent is water;
(b) the thickening agent is carbomer;
(c) the preservative synergist is p-hydroxyacetophenone;
(d) the chelating agent is EDTA disodium;
(e) the humectant is at least one of glycerol, butanediol and 1, 2-hexanediol;
(f) the emollient is at least one of sucrose acetate butyrate and hydrogenated poly-maltene;
(g) the auxiliary emulsifier is cetostearyl alcohol;
(h) the efficacy additive is arginine.
The preferred embodiment of the repair cream comprises the following components in parts by weight: 2.5-12 parts of emulsifier, 0.4-6 parts of skin repair additive, 0.03-2 parts of anti-allergy additive, 10-100 parts of water, 0.02-0.35 part of carbomer, 0.2-0.8 part of p-hydroxyacetophenone, 0.01-0.12 part of EDTA disodium, 3-15 parts of glycerol, 0.38-2.25 parts of butanediol, 0.2-2 parts of 1, 2-hexanediol, 2-10 parts of sucrose acetate butyrate, 3-15 parts of hydrogenated polyprenol, 0.4-5 parts of cetearyl alcohol and 0.15-0.7 part of arginine.
In a third aspect, the invention further provides a preparation method of the repair cream, which comprises the following steps:
(1) adding the phase A material into a water phase pot, stirring and heating to 80-85 deg.C, and keeping the temperature for 10-30min, wherein the phase A material is carbomer, p-hydroxyacetophenone, disodium EDTA, glycerol and part of water;
(2) adding the phase B materials into an oil phase pot, stirring and heating to 80-82 ℃, wherein the phase B materials are an emulsifier, a skin repair additive, sucrose acetate butyrate, hydrogenated polyprenol and cetostearyl alcohol;
(3) pumping the phase A material into an emulsifying pot, starting high-speed homogenizing, vacuumizing, sucking the phase B material, homogenizing for 5-8min, keeping the temperature for 5-20min, and cooling;
(4) when the temperature is reduced to 60 ℃, adding the pre-mixed C-phase material, and homogenizing at 1200-2000rpm for 5-10min, wherein the C-phase material is arginine and part of water;
(5) when the temperature is reduced to 45 ℃, adding a pre-mixed D-phase material, and uniformly stirring, wherein the D-phase material is an anti-allergy additive, butanediol, 1, 2-hexanediol and the rest part of water;
(6) and cooling to below 40 ℃ to obtain the repair cream.
Compared with the prior art, the invention has the beneficial effects that:
according to the technical scheme, the emulsifier, the skin repair additive and the anti-allergy additive of specific types are compounded in a specific proportion to form a composition system, and the components synergistically play a lasting moisturizing function, can assist in skin barrier repair, and can reduce the problems of dry peeling, red and itchy skin and fragile and sensitive skin of infants.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
The compositions of the long-term moisturizing repair compositions of examples 1 to 12 and comparative examples 1 to 9 are shown in table 1 below.
TABLE 1 Long-term moisturizing repair compositions of examples 1-12 and comparative examples 1-9 (parts by weight of each component)
The long-acting moisturizing repair compositions of examples 1-12 and comparative examples 1-9 were applied to the preparation of repair creams, which include at least one of a solvent, a thickener, a preservative synergist, a chelating agent, a humectant, an emollient, a co-emulsifier, and an efficacy additive, in addition to the long-acting moisturizing repair composition. Wherein the solvent is water; the thickening agent is carbomer; the antiseptic synergist is p-hydroxyacetophenone; the chelating agent is EDTA disodium; the humectant is at least one of glycerol, butanediol and 1, 2-hexanediol; the emollient is at least one of sucrose acetate butyrate and hydrogenated poly-maltene; the auxiliary emulsifier is cetostearyl alcohol; the efficacy additive is arginine.
The selection of the other components in the repair cream of the invention except the long-acting moisturizing repair composition can be adjusted according to the actual situation. For comparison, the types and amounts of the components other than the long-lasting moisturizing repair composition in the examples and comparative examples of the present invention were the same. The components of examples 1 to 12 and comparative examples 1 to 9 of the invention are respectively mixed with the following components in parts by weight: 72.5 parts of water, 0.15 part of carbomer, 0.5 part of p-hydroxyacetophenone, 0.01 part of EDTA disodium, 8 parts of glycerol, 0.75 part of butanediol, 0.5 part of 1, 2-hexanediol, 5 parts of sucrose acetate butyrate, 10 parts of hydrogenated polyprenol, 1.2 parts of cetearyl alcohol and 0.33 part of arginine are mixed to prepare corresponding repair cream (the repair cream is experimental examples 1-12 and comparative experimental examples 1-9).
The preparation methods of the repair creams of the experimental examples 1-12 and the comparative experimental examples 1-9 are the same, and specifically comprise the following steps:
(1) adding the phase A materials into a water phase pot, stirring at 80rpm, heating to 80-85 deg.C, and keeping the temperature for 15min, wherein the phase A materials are carbomer, p-hydroxyacetophenone, disodium EDTA, glycerol and part of water;
(2) adding the phase B materials into an oil phase pot, stirring at 60rpm, and heating to 80-82 deg.C, wherein the phase B materials are emulsifier, skin repairing additive, sucrose acetate butyrate, hydrogenated polyprenol and cetostearyl alcohol;
(3) pumping the phase A material into an emulsifying pot, homogenizing at 3000rpm for 5-8min, vacuumizing, sucking the phase B material, keeping the temperature for 10min, and cooling;
(4) cooling to 60 deg.C, adding pre-mixed C phase material, homogenizing at 1500rpm for 5-10min, wherein the C phase material is arginine and part of water;
(5) when the temperature is reduced to 45 ℃, adding a pre-mixed D-phase material, and uniformly stirring, wherein the D-phase material is an anti-allergy additive, butanediol, 1, 2-hexanediol and the rest of water;
(6) and cooling to below 40 ℃ to obtain the repair cream.
The repair cream products prepared in experimental examples 1 to 12 and comparative experimental examples 1 to 9 were subjected to performance tests.
First, product appearance and physical and chemical index test
1. Heat resistance: after the repair cream products prepared in the experimental examples 1-12 and the comparative experimental examples 1-9 are placed at 45 +/-2 ℃ for 3 months, the temperature is restored to room temperature, and the products are not abnormal;
2. cold resistance: after the repair cream products prepared in the experimental examples 1-12 and the comparative experimental examples 1-9 are placed at-17 +/-2 ℃ for 3 months, the temperature is restored to room temperature, and the products are not abnormal;
3. and (3) cycle testing: the repair cream products prepared in the experimental examples 1-12 and the comparative experimental examples 1-9 are placed for 3 months under the three conditions of 45 +/-2 ℃, normal temperature and-17 +/-2 ℃ in sequence, and after 5 times of repetition, no abnormality exists in the products.
Second, evaluation of safety
Cosmetic irritation evaluation was performed using the repair cream products prepared in examples 1 to 12 and comparative examples 1 to 9 as test substances.
The test population: 75 infants, between 6 months and 5 years of age, have healthy skin and no history of skin allergy and meet the voluntary enrollment standard of the subjects;
grouping: dividing the tested population into 15 groups of 5 persons, wherein the age difference of each member in the group is not more than 1 year old;
the spot pasting method comprises the following steps: selecting a qualified spot tester, placing 0.020-0.025g of a tested object in the spot tester in a closed spot patch experimental mode, attaching the spot tester with the tested object to the bent side of the back or forearm of a tested object by using a non-irritating adhesive tape, slightly pressing the spot tester with a palm to uniformly attach the spot tester to the skin, removing the tested object after 24 hours, observing skin reactions after 0.5, 6, 12, 24 and 48 hours after removal, and recording the results according to skin reaction grading standards in cosmetic hygiene standards and cosmetic safety technical standards; the irritation evaluation criteria are shown in table 2 below, and the test results are shown in table 3 below.
TABLE 2 irritation evaluation criteria
TABLE 3 irritation test results of repair cream products of Experimental examples 1-12 and comparative Experimental examples 1-9
As can be seen from Table 3, the results of the patch test on human skin show that the skin reactions of all the test subjects are negative when the test subjects pass the patch test on the test substances of all the test subjects, and the skin reactions of all the test subjects are observed at 0.5 hour, 6 hours, 12 hours, 24 hours and 48 hours, which indicates that the repair cream products prepared in the experimental examples 1 to 12 and the comparative experimental examples 1 to 9 of the present invention are safe to use.
Evaluation of moisturizing Effect
The moisturizing effect test is carried out on the repairing cream products prepared in the experimental examples 1-12 and the comparative experimental examples 1-9 according to QBT 4256-.
The tested population is 75 infants, the infants are between 6 months and 5 years old, the skin is healthy, no allergic history of the skin disease exists, the voluntary selection standard of the tested subject is met, and the inner sides of the forearms of both hands of the tested part do not receive skin treatment, beautifying and the like;
the test environment temperature is controlled to be 21-23 ℃, and the air humidity is controlled to be 55-65%;
testing an instrument: MoistureMeter SC (Delfin);
before testing, wiping the test piece by using dry facial tissue, marking a measuring area on a corresponding tested part, wherein the area of the testing area is 3cm multiplied by 4cm, each testing area is 1cm apart, standing for 20min, and then starting to measure a blank value, uniformly coating a sample in the measuring area according to the dosage of (2.0 +/-0.1) mg/cm2, and taking coated purified water as a blank group; and measuring the moisture content value of the skin at 0.1h, 0.5h, 1.5h, 2.5h, 4h and 6h after coating, and obtaining a moisture content increase value by subtracting the moisture content increase value from the blank value, wherein the greater the value, the better the moisturizing effect of the test sample.
The test results were expressed as the average of the change values of the water content before and after application, as shown in Table 4 below.
TABLE 4 moisturizing effect test results of repair cream products of examples 1-12 and comparative examples 1-9
As can be seen from table 4, the repair cream products prepared in experimental examples 1 to 12 all had good moisturizing effects, wherein the moisturizing effects of experimental examples 3 to 9 were superior to those of experimental examples 1 to 2 and experimental examples 10 to 12, and particularly the moisturizing effect of experimental example 4 was the best.
Compared with the experimental example 4, the comparative experimental examples 5-8 respectively do not contain emulsifying agents, C10-18 fatty acid triglycerides, C20-22 alcohol phosphate and C20-22 alcohol, the comparative experimental examples 1-4 respectively do not contain skin repair additives, ceramide NP, phytostanol and linoleic acid, and the comparative experimental example 9 does not contain gentian root extracts, and the experimental results show that the moisturizing effects of the repair creams prepared in the comparative experimental examples 1-9 are obviously lower than those of the repair creams prepared in the experimental examples 1-12, and the moisturizing effects of the repair creams prepared in the comparative experimental examples 5-8 are also obviously lower than those of the repair creams prepared in the comparative experimental examples 1-4 and 5. Therefore, the long-acting moisturizing repair composition disclosed by the invention can realize a good moisturizing effect only by virtue of the synergistic effect of the emulsifiers (comprising C10-18 fatty acid triglycerides, C20-22 alcohol phosphate and C20-22 alcohol), the skin repair additives (ceramide NP, plant catalpol and linoleic acid) and the anti-allergy additives (gentian root extract), and the lack of any component can influence the exertion of the moisturizing effect, and the emulsifiers (comprising C10-18 fatty acid triglycerides, C20-22 alcohol phosphate and C20-22 alcohol) have very important significance in exerting the good moisturizing effect on the composition.
Fourth, evaluation of skin Barrier repair
The evaluation method comprises the following steps: a skin damage model is established by SDS stimulation of a certain concentration, test samples are continuously smeared on damaged skin for 14 days, and the repairing efficacy of the samples on the damaged skin caused by the SDS stimulation is evaluated through skin heme and percutaneous water loss TEWL tests.
The tested population is 12 dry skin infants (age 6 months 2, 1 year 2, 2 years 4 and 4 years 4), and the inner sides of the forearms of both hands of the tested part do not receive skin treatment, beauty treatment and the like;
the test samples of example 1, comparative examples 1 to 4 and comparative examples 9 to 10 were used every night for 14 days using purified water as a blank; the test environment temperature is controlled to be 21-23 ℃, and the air humidity is controlled to be 55-65%;
the skin heme index (EI value) of the test area was measured using a skin heme tester Mexameter (MX18, Courage and khazaka, germany), and the test results are shown in table 5 below;
subjects were tested for transdermal water loss at the test site (TEWL average) on days 0, 2, 4, 7, and 14 using the VAPOMeter SC (Delfin), respectively, with the results shown in table 6 below.
Note: (1) the larger the skin heme index EI value is, the higher the skin heme content is, the poorer the red removing effect is, and the poorer the corresponding skin repairing effect is;
(2) the larger the mean value of skin TEWL, the faster the transdermal water loss of the skin and the poorer the corresponding skin barrier repair effect.
TABLE 5 results of tests on heme index (EI value) of repair cream products of Experimental examples 1-12 and comparative Experimental examples 1-9
TABLE 6 test results of percutaneous Water loss (TEWL mean) of repair cream products of Experimental examples 1-12 and comparative Experimental examples 1-9
| Test product | Day 0 | Day 2 | Day 4 | Day 7 | Day 14 |
| Experimental example 1 | 67.9 | 41.6 | 35.5 | 33.5 | 26.3 |
| Experimental example 2 | 68.4 | 42.3 | 34.4 | 32.0 | 26.9 |
| Experimental example 3 | 68.9 | 38.5 | 29.9 | 27.1 | 25.0 |
| Experimental example 4 | 67.2 | 36.9 | 26.2 | 21.4 | 21.0 |
| Experimental example 5 | 68.1 | 39.2 | 30.3 | 26.1 | 24.8 |
| Experimental example 6 | 66.9 | 38.7 | 29.9 | 27.3 | 23.9 |
| Experimental example 7 | 67.3 | 39.3 | 29.7 | 26.7 | 24.2 |
| Experimental example 8 | 66.6 | 38.2 | 29.1 | 28.1 | 24.9 |
| Experimental example 9 | 67.9 | 40.0 | 30.5 | 28.8 | 25.1 |
| Experimental example 10 | 68.2 | 41.3 | 32.9 | 31.4 | 27.0 |
| Experimental example 11 | 64.3 | 42.3 | 33.2 | 31.7 | 28.9 |
| Experimental example 12 | 66.4 | 41.4 | 32.8 | 31.0 | 27.9 |
| Comparative Experimental example 1 | 63.9 | 50.5 | 45.9 | 43.2 | 40.1 |
| Comparative experiment example 2 | 62.7 | 46.4 | 42.7 | 38.2 | 35.8 |
| Comparative experiment example 3 | 65.3 | 49.6 | 46.3 | 40.4 | 37.5 |
| Comparative experiment example 4 | 63.6 | 47.7 | 43.8 | 39.2 | 36.8 |
| Comparative experiment example 5 | 67.2 | 45.2 | 38.1 | 35.5 | 33.2 |
| Comparative experiment example 6 | 68.3 | 43.2 | 36.2 | 34.8 | 32.2 |
| Comparative experimentExample 7 | 66.5 | 41.8 | 37.9 | 33.1 | 31.8 |
| Comparative Experimental example 8 | 64.9 | 42.0 | 37.3 | 32.2 | 32.1 |
| Comparative Experimental example 9 | 60.5 | 41.3 | 37.8 | 33.2 | 29.5 |
| Blank group | 65.6 | 53.2 | 48.1 | 45.2 | 40.4 |
As can be seen from tables 5 and 6, the repair cream products prepared in the experimental examples 1 to 12 all have good skin barrier repair effects, wherein the skin barrier repair effects of the experimental examples 3 to 9 are better than those of the experimental examples 1 to 2 and the experimental examples 10 to 12, and particularly the skin barrier repair effect of the experimental example 4 is the best.
The ratio of the three components in the skin repair additive in experimental examples 4-7 is different, wherein the weight ratio of the ceramide NP, the phytosterol and the linoleic acid in the experimental example 4 is 2:1:1, while the ratio of the three components in the experimental examples 5-7 is different from that in the experimental example 4, the experimental result shows that the skin barrier repair effect of the repair cream prepared in the experimental example 4 is better to achieve the effects of good absorption and barrier function establishment when the weight ratio of the ceramide NP, the phytosterol and the linoleic acid in the skin repair additive is 2:1: 1.
Compared with the experimental example 4, the comparative experimental examples 5 to 8 do not contain emulsifier, C10-18 fatty acid triglyceride, C20-22 alcohol phosphate and C20-22 alcohol respectively, the comparative experimental examples 1 to 4 do not contain skin repair additive, ceramide NP, plant catalpol and linoleic acid respectively, and the comparative experimental example 9 does not contain gentian root extract, and the experimental results show that the skin barrier repair effect of the repair cream prepared in the comparative experimental examples 1 to 9 is obviously lower than that of the repair cream prepared in the experimental examples 1 to 12, and the skin barrier repair effect of the repair cream prepared in the comparative experimental examples 1 to 4 is also obviously lower than that of the repair cream prepared in the comparative experimental examples 5 to 9. Therefore, the long-acting moisturizing repair composition can achieve good skin barrier repair effect only by the synergistic effect of the emulsifier (comprising C10-18 fatty acid triglycerides, C20-22 alcohol phosphate and C20-22 alcohol), the skin repair additive (ceramide NP, plant catalpol and linoleic acid) and the anti-allergy additive (gentian root extract), and the lack of any component can influence the exertion of moisturizing effect.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The long-acting moisturizing repair composition is characterized by comprising the following components in parts by weight: 2.5-12 parts of emulsifier, 0.4-6 parts of skin repair additive and 0.03-2 parts of anti-allergy additive, wherein the emulsifier is composed of C10-18 fatty acid triglycerides, C20-22 alcohol phosphate and C20-22 alcohol, the skin repair additive is composed of ceramide NP, phytosterol and linoleic acid, and the anti-allergy additive is gentian root extract.
2. The long-acting moisturizing repair composition of claim 1, wherein the emulsifier is composed of, by weight, 1-6 parts of C10-18 fatty acid triglycerides, 1.2-4.8 parts of C20-22 alcohol phosphate, and 0.3-1.2 parts of C20-22 alcohol; the skin repair additive consists of 0.2-3 parts of ceramide NP, 0.1-1.5 parts of phytosterol and 0.1-1.5 parts of linoleic acid.
3. The long-acting moisturizing repair composition of claim 2, wherein the emulsifier is composed of 3-4 parts by weight of C10-18 fatty acid triglycerides, 2-3 parts by weight of C20-22 alcohol phosphate and 0.5-1 part by weight of C20-22 alcohol; the skin repair additive consists of 0.5-1.5 parts of ceramide NP, 0.2-1 part of phytosterol and 0.2-1 part of linoleic acid.
4. The long-acting moisturizing repair composition of claim 3, wherein the weight ratio of ceramide NP, phytosterols, and linoleic acid in the skin repair additive is ceramide NP: phytosterols: linoleic acid 2:1: 1.
5. A repair cream comprising the long-lasting moisturizing repair composition of any one of claims 1-4.
6. The repair cream of claim 5 further comprising at least one of a solvent, a thickener, a preservative synergist, a chelating agent, a humectant, an emollient, a co-emulsifier, and an efficacy additive.
7. The repair cream of claim 6, further comprising the following components in parts by weight: 10-100 parts of solvent, 0.02-0.35 part of thickening agent, 0.2-0.8 part of preservative synergist, 0.01-0.12 part of chelating agent, 3.5-20 parts of humectant, 5-25 parts of emollient, 0.4-5 parts of co-emulsifier and 0.15-0.7 part of efficacy additive.
8. The repair cream of claim 6 or 7, comprising at least one of the following (a) to (h):
(a) the solvent is water;
(b) the thickening agent is carbomer;
(c) the preservative synergist is p-hydroxyacetophenone;
(d) the chelating agent is EDTA disodium;
(e) the humectant is at least one of glycerol, butanediol and 1, 2-hexanediol;
(f) the emollient is at least one of sucrose acetate butyrate and hydrogenated poly-maltene;
(g) the auxiliary emulsifier is cetostearyl alcohol;
(h) the efficacy additive is arginine.
9. The repair cream of claim 8, comprising the following components in parts by weight: 2.5-12 parts of emulsifier, 0.4-6 parts of skin repair additive, 0.03-2 parts of anti-allergy additive, 10-100 parts of water, 0.02-0.35 part of carbomer, 0.2-0.8 part of p-hydroxyacetophenone, 0.01-0.12 part of EDTA disodium, 3-15 parts of glycerol, 0.38-2.25 parts of butanediol, 0.2-2 parts of 1, 2-hexanediol, 2-10 parts of sucrose acetate butyrate, 3-15 parts of hydrogenated polyprenol, 0.4-5 parts of cetearyl alcohol and 0.15-0.7 part of arginine.
10. The method for preparing a repair cream according to claim 9, comprising the steps of:
(1) adding phase A materials into a water phase pot, stirring and heating to 80-85 deg.C, and keeping the temperature for 10-30min, wherein the phase A materials are carbomer, p-hydroxyacetophenone, disodium EDTA, glycerol and part of water;
(2) adding the phase B materials into an oil phase pot, stirring and heating to 80-82 ℃, wherein the phase B materials are an emulsifier, a skin repair additive, sucrose acetate butyrate, hydrogenated polyprenol and cetostearyl alcohol;
(3) pumping the phase A material into an emulsifying pot, starting high-speed homogenizing, vacuumizing, sucking the phase B material, homogenizing for 5-8min, keeping the temperature for 5-20min, and cooling;
(4) when the temperature is reduced to 60 ℃, adding the pre-mixed C-phase material, and homogenizing at 1200-2000rpm for 5-10min, wherein the C-phase material is arginine and part of water;
(5) when the temperature is reduced to 45 ℃, adding a pre-mixed D-phase material, and uniformly stirring, wherein the D-phase material is an anti-allergy additive, butanediol, 1, 2-hexanediol and the rest part of water;
(6) and cooling to below 40 ℃ to obtain the repair cream.
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| CN114917155A (en) * | 2022-05-11 | 2022-08-19 | 广州天玺生物科技有限公司 | Centella asiatica-containing composition suitable for repairing sensitive muscles and application thereof |
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