JP2007131571A - Hair papilla cell proliferation enhancer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To find out a new and safe component having hair papilla cell proliferation enhancing activity and apply the component to hair growth tonic/pilatory. <P>SOLUTION: The invention relates to the hair papilla cell proliferation enhancer having hair papilla cell proliferation enhancing activity comprising at least three kind of extracts of sea weeds selected from family Laminaria, Alaria, Lessonia, Fucus, Sargassum, Solieria, Gigartina, Grateloupia, Gelidium, Gracilaria or Ulva. A composition effective for hair growth activity, hair growth enhancing activity is obtained by formulating above to the hair growth tonic/pilatory as the active component. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a novel and safe hair papilla cell proliferation promoter and a hair growth / hair nourishing agent containing the same.

It is said that dermal papilla cells are located in the hair follicle, which is the basis of hair, and control hair growth. Promoting the proliferation of dermal papilla cells is very important in considering hair growth and hair growth of body hair such as head hair. Aloe, Arnica (Rabbit Giku), Ogon, Kakon, Kanokoso, Chamomile (Chami), Kawara Mugwort, Licorice, Rice Blossom, Peonies, Loofah Extract (see Patent Document 1) and Ambret Seed Essential oil (see Patent Document 2) has been reported, but none of the drugs satisfies all of safety, stability, and efficacy.
Japanese Patent Laid-Open No. 11-240823 JP 2005-213143 A

  Therefore, an object of the present invention is to find a new and safe active ingredient having an excellent dermal papilla cell proliferation promoting action and to apply it to a hair growth / hair restoration agent.

    As a result of diligent research on ingredients having a hair papillary cell proliferation promoting action, the present inventor has found that the family Kombu, Tigaiso, Lessonia, Hibamata, Honda, Mirin, Suginotori, Mukadenori, Tengusa, Ogonori The present inventors have found that a seaweed extract mixture containing three or more kinds of seaweed extracts selected from the heronaceae has the above-mentioned action and has completed the present invention.

  Furthermore, the present invention was completed by providing a hair papilla cell proliferation promoter containing a seaweed extract comprising the family Kombu, Chigasiaceae, Lessoniaceae, Hibamata, and Honda.

Furthermore, the present invention was completed by providing a hair papilla cell growth promoter containing a seaweed extract comprising the following (A), (B) and (C).
(A) One or two or more seaweed extracts selected from the family Kombu, Chigasiaceae, Lessoniaceae, Hibamata, Hondada, (B) Selected from the family Milinaceae, Sugiori, Muchadenori, Proboscis, Ogonori 1 or 2 or more seaweed extracts and (C) 1 or 2 or more seaweed extracts selected from the heronid family

  Furthermore, the hair growth and hair nourishing agent which contains 1 type, or 2 or more types chosen from the said hair papilla cell growth promoter as an active ingredient is provided.

  Three or more kinds of seaweed extracts selected from the family Kombu, Tigaiso, Lessonia, Hibamata, Hondaraceae, Mylinaceae, Suginotori, Muchadenori, Tengusa, Ogonori, Aoshia which are active ingredients of the present invention It was confirmed that the seaweed extract mixture containing the seaweed extract mixture containing has excellent hair papilla cell proliferation promoting action. Moreover, it became possible to provide the composition effective in the hair growth effect and the hair growth promotion effect by mix | blending this with a hair growth and a hair nourishing agent as an active ingredient.

  The product of the present invention comprises a seaweed extract belonging to three or more kinds of seaweeds belonging to the following families. Although a suitable use site | part is mentioned, it is not limited to these.

  As seaweeds of the family Kombuidae, the sea turtle (E.arborea) classified in the genus Eisenia (E. cava; E. latifolia), chrome (E. kurome), etc. ), Alame (E.bicyclis), etc., Kagome (K. crassifolia) classified into the genus Klollum (K. crassifolia), Trolocomb (K. gyrata; Laminaria gyrata), etc. angustata), Macombu (L. japonika; L. fragilis; Fucus saccharinus), Resilib (L. japonica var. ochotensis; L. ochotensis), Hosome Kombu (L. religiosa), and L. cloustoni .

  As seaweeds of the family Chigaisoaceae, A. crassifolia (A. crassifolia), A. praelonga (A. yezoensis; A. corrugata), etc., the green sea turtle (U. Typical examples include peterseniana), wakame (U. pinnatifida; Alaria pinnatifida), and Hirome undarioides.

  The seaweeds that belong to the Lessonia family include Macrocystis pyrifera, Macrocystis integrifolia, Nereocystis leutkeana, Lessonia fuscescens, Lessonia nigrescens. (L. nigrescens), Lessonia pirifera (L. trabeculata) and the like are typical examples, and seaweed that forms a vast underwater forest generally called giant kelp can be used.

  As seaweeds belonging to the family Hibamata, Ascophyllum nodosum belonging to the genus Ascophyllum such as F.distichus Linnaeus subsp.evanescens; Fucus evanescens; (A.nodosum) and the like are typical examples.

  Representative examples of seaweeds belonging to the family Hawkidae include hinoki (H. fusiforme; Cystophyllum fusiforme; Turbinaria fusiformis; Sargassum fusiforme) classified into the genus Hizikia.

  As seaweeds belonging to the family Milinaceae, E. amakusaensis, E. cupressoideum (E. arnoldii), E. denticulata (E. denticulata), which are classified into the genus Eucheuma, E. denticulata; Muricatum; E. spinosum; Fucus denticulatus), E.serra; Sphaerococcus serra, etc. Typical examples include mirin (S. pacifica; S. robusta; Chrysymenia pacifica), hosobamilin (S. tenuis; S. mollis) and the like classified into the genus Solieria.

  As seaweeds belonging to the cedar family, Kainori (G. intermedius; Gigartina intermedia), Shikinori (C. teedii; Gigartina teedii; Ceramium teedii), C. tenellus (C. tenellus); Gigartina tenella; C .Filiformis), etc., which are classified into the genus Chondrus (C. armatus; Cystoclonium armatus), Yahuzunomata (C. crispus), C. elatus; Gigartina elata, .giganteus; C.ocellatus f.giganteus), prickly pear (C.giganteus f.flabellatus), C.ocellatus, C.pinnulatus, C.verrucosus; C.ocellatus f.canaliculatus; Gigartina mikamii; G.verrucosa; G.inubozakiensis), Ezotsunomata (C.yendoi), and the like.

  As seaweeds belonging to the genus Solanumae, the genus Grateloupia is classified into G.elliptica, G.filicina, G.lanceolata, Pachymeniopsis lanceolata, and G.sparsa; Cyrtymenia sparsa A typical example is G. turuturu.

  The seaweeds belonging to the family Tengusaceae include A. japonica, which is classified as Acanthopeltis, G. acerosa, Fucus acerosus; Gelidium rigidum, etc. P. capillacea classified as Pterocladiella, such as G. amansii (G. elegans), G. japonicum; Onikusa japonica, etc. Pterocladia tenuis), P.densa, etc., such as Ptilophora subcostata; Gelidium subcostatum; Beckerella subcostata, etc., Y. bersa classified as Yatabella Is a typical example.

  The seaweeds belonging to the family Gogonori include the genus Gracilaria (Gracilariopsis; Polycavernosa; Hydropuntia), G. chorda, G. textorii; Sphaerococcus textorii, G. vermiculophylla; G. confervoides; G.verrucosa; G. rhodotrucha; G. asiatica) and the like.

  As seaweeds belonging to the family Aosaceae, Nagaaosa (U.arasakii), Button Aosa (U.conglobata), Jagrel (U.japonica; Letterstedtia japonica), O.lactuca (U.lactuca; U. latissima), Aosa (Aanaosa) (U. pertusa), etc., and the genus Enteromorpha, E.compressa; Ulva compressa, E.crinita; Conferva crinita; E. ramulosa, E .intestinalis (Ulva intestinalis), Usba aonori (E.linza; E.bulbosa var.japonica; Ulva linza), Sugiaonori (E.prolifera; Ulva prolifera), and the like.

  The seaweed extract used in the present invention is three or more kinds of seaweeds selected from the family Kombu, Tigaiso, Lessonia, Hibamata, Hondara, Mirin, Sugiori, Centipedeaceae, Probosidae, Ogonoriaceae It can also be obtained by mixing three or more extracts obtained from each seaweed body. The mixing ratio is not particularly defined and can be adjusted as appropriate.

  The seaweed extract used in the present invention is extracted by adding a solvent to the squeezed solution and / or the residue obtained after the squeezing treatment in addition to those obtained by directly extracting from each seaweed body using a solvent. What is obtained by doing so is also included in the scope of the definition of the extract in the present invention. In addition, it is possible to use a supercritical extraction method using a supercritical fluid using carbon dioxide, carbon dioxide gas, or the like.

  The extraction solvent for obtaining the seaweed plant extract to be used in the present invention may be selected in consideration of the purpose of use, the type of the product to be provided, or the processing to be performed later. Usually, water, methanol, Lower alcohol or hydrous lower alcohol such as ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentane Polyhydric alcohols such as diol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight: 100,000 to 100,000) or water-containing Polyhydric alcohol, acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether Various organic solvents such as ru, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., and acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis that have been appropriately adjusted It is desirable to use one or a mixture of two or more selected from (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, if it is not preferable to use a solvent depending on the application, use only water, or perform extraction with a highly volatile solvent that can be easily removed after extraction, and dissolve in water after removing the solvent. Such a method is also possible. Moreover, you may perform extraction extraction suitably.

  In addition to hydrolytic extraction of the above-mentioned various seaweeds by enzymatic decomposition, those obtained by hydrolysis with acid / alkali can also be used.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set within the range of -4 ° C to 100 ° C, and it can be set at high pressure or low pressure in addition to normal pressure. Is preferred. Also, the weight ratio of the solvent to the raw material can be arbitrarily set within a range of, for example, raw material: solvent of 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:20 is particularly preferable.

  The extract can be further subjected to a purification operation after solvent extraction. Examples of the purification operation include acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or alkali (sodium hydroxide, calcium hydroxide, Decomposition by addition of ammonia, etc., fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resin, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange, hydrophilic adsorption, hydrophobic adsorption, size exclusion, ligand) Fractionation using chromatography with exchange, affinity, etc., filtration using filter paper or membrane filter, ultrafiltration membrane, etc., pressurization or decompression, heating or cooling, drying, pH adjustment, deodorization, decolorization, long For example, stationary storage of time can be exemplified, and it is possible to perform processing by arbitrarily selecting and combining these.

  The form of the hair papilla cell growth promoter used in the present invention and the hair growth / hair nourishing agent containing the same may be any form such as liquid, solid, powder, paste, gel, etc., and constitutes the final product The optimum shape can be arbitrarily selected. Depending on the dosage form, these can be administered or ingested to humans by any route such as oral, enteral, injection, transmucosal, transdermal, etc., but by external routes such as transmucosal and transdermal. It is preferable to use it.

  The dosage form of the dermal papilla cell growth promoter and the hair-restoring / hair-restoring agent containing it is arbitrary, ampoules, capsules, powders, granules, pills, tablets, solids, liquids, gels, bubbles , Emulsions, creams, ointments, sheets, mousses, powder dispersions, multilayers, aerosols, and other cosmetic compositions, pharmaceuticals, quasi-drugs or foods and beverages. .

  The field of use can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (for example, lotion, milky lotion) , Basic cosmetics such as cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-show lotion, Makeup cosmetics such as shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail preparation, nail enamel, nail enamel Leavening agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, hairs) Treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plaster agents, tape agents, sheet agents, patch agents, aerosol agents, etc.), 5) bath water 6) In addition, anti-smell and deodorant, deodorant, antiperspirant, hygiene products, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, etc. . Particularly preferred are scalp cosmetics such as lotions for scalp, scalp creams, aerosols for scalp, hair growth agents, hair nourishing agents, and hair loss prevention agents.

  Furthermore, as foods and drinks, oral compositions (gum, candy, etc.), processed fishery products such as kamaboko and chikuwa, livestock products such as sausages and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat etc. Seasonings such as noodles, sauce, soy sauce, sauce, sugar, honey, powdered candy, syrup, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, red vegetables, sprinkles, or Processed vegetables and fruits such as canned and bottled vegetables, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey drink, soft drink, alcoholic beverages, etc. It can be used for general foods and drinks such as health foods.

  In addition, as applications in the fields of regenerative medicine and beauty formation, there are applications to growth media for animal-derived dermal papilla cells such as humans, their additives, and coating agents for culture vessels.

  The content of the seaweed extract as an active ingredient of the present invention varies slightly depending on the type, quality, and expected action of the hair papilla cell growth promoter and hair growth / hair nourishing agent, but is not particularly limited. When contained in terms of solid content, about 0.0001 to 20% by mass, preferably about 0.01 to 10%, usability and good effects can be obtained.

  The hair papilla cell growth promoter of the present invention and the hair growth / hair nourishing agent containing the same include the components and additives exemplified below within the range not impairing the effects of the present invention, if necessary, in addition to the above essential components. It can be selected and used in combination. The content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber oil, safflower oil , Shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, palm Oil, beef tallow, pork tallow, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil, etc.).

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.

(3) Mineral oils Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid Synthetic fatty acids such as natural fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) Alcohols: natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol .

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, Diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) gum, sugar or water-soluble polymer compound gum arabic, benzoin rubber, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or ester thereof, Trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular chitin Or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose Polycarboxylate such as carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide Alkylene oxide or its crosslinked polymer, carboxyvinyl polymer, polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric Surfactant: Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant ( Ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants ( Natural surfactants, protein hydrolyzate derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbons System surfactant) and the like.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), Riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: Ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), me Dione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine , Arginine, ornithine, histidine and the like, and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate or pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, enzymatic degradation, Perform any process from fermentation, purification, compression, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol , Lower alcohols such as isobutanol or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyhydric alcohol such as polyethylene glycol (molecular weight 100 to 100,000) or water-containing polyhydric alcohol, acetone, ethyl acetate, Diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xy , Benzene, chloroform, carbon tetrachloride, various organic solvents such as phenol, toluene, etc., and acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, water, etc.) prepared as appropriate. It is desirable to use one or a mixture of two or more selected from potassium oxide, calcium hydroxide, ammonia and the like. However, if it is not preferable to contain an organic solvent depending on the purpose of use, use only water or perform extraction using a highly volatile solvent that can be easily removed after extraction, and use purified water after removing the solvent. It is also possible to use a method such as dissolving in a solution.

  In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relaxation, stress relief by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, imparting gloss, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.

  In addition, in food and drink, nutritional supplementation, fatigue recovery, tonicity, cell activation (cell aging prevention) and other healthy and cosmetic effects, as well as improved taste, color and aroma, gloss, stabilization, thickening, It can be used for antiseptic purposes. In addition to this, various cosmetic and pharmaceutical effects of each of the known raw materials are expected, and by combining these, the intended effect can be promoted or multifunctional. It is also possible to make the product expected to be effective.

Specific plants (herbal medicines) as raw materials include, for example, almonds (toen), ai (indigo leaves), aokazura (Keifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Samurai (wooden candy) , Aotenma, acacia, red ginseng, red spruce `` fruit '', red clover, red grapes, red ginseng (logwood), red wrinkles (red buds), red crested or red crested or reddish (root), red crested or reddish (ground yellow), Agi (Aki), Aki larch, Akinire (crusted skin), Aguay Guassou, Aguahe (Omiten coconut palm), Akebi (Kitsu), Asa (Asakojin), Maruba morning glory or morning glory (Chicken), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asenyaku), Athira (Shokuyokanna), Anise, Abiyu, A Biurana, oilseed rape, Abemaki `` fruit '', avocado, ama, achacha (Amacha), Achacharu, Amadokoro (Jade bamboo), Amana (a light-hearted), amaranth (Hyuyu, Hagatetou, Himogeito, Senninkoku, Sugimorigateto, Hosoaogeito, Hasoagoito Aozulan, Amaranthus hypochondriacus), Amigasayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Arcana (Alcanna), Algarrobo (Cabe), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe (蘆薈), Aloe vera, angelica, apricot or honanzu (Anzujin), Ansokkou (benzoic incense), yellow support, igakozolina (geo-biliary head), licorice or gecko licorice (indian oyster), rush (light heart grass), itadori (tiger cane root), yew (one Place), Strawberry, fig (no flower `` fruit, leaf ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one medicinal herb), ginkgo (Ginkgo `` seed, leaves ''), Japanese yellow peas (distant), carob, Japanese beetle ( Taillexi), Inubiyu (Honagainubiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibuki-so-sou, Nettle, Ylang-ylang, Iwa-tobacco (Iwabuchi), Iwahiba or Iwamatsu (rolling mushroom), kidney beans, oolong tea, fennel (mustard) , Wheat (Chibusanoki), Ukiyara (Sanryo), Uguisukagura `` Fruit '', Himewikyo, Turmeric (Urban), Duckweed, Usubasaishin or Keirinsaishin or Oshusaishin (spicy), Usvenia Oy, Usbeni Hollyhock, phalaenopsis, weevil (summer hay), udo or shishiudo (gung, alone, tangy), unyadegato (unkari) A, Cat's Claw), Uba tea, Ume (Japanese apricot `` seed, pulp ''), Japanese white beetle, Uwaurushi (Kusako-kemomo), Unshuumika (Chen), Unboku, Estragon, Ezoukogi (Tomogoka), Ezo-suzuran, Echinashi (Hosobamurasaki Barengiku) , Enishida, Enokitake (榎 茸), Ebisugusa or Cassia Tora (Keiko), El Campre, Elderberry “fruit”, Elemi, Elingi or Pre-Lotus Elinji, Enju (Safflower, Camellia rice), Pea, Ogi or Kibanaogi (Yellow Twilight), Naruko Yuri or Kagura-mabanaru Koyuri (Yellow), Ohisasa Yuki or Sasano Yuki, Ouren (Yo Ren), Ogata Houken, Okarasuri (Karokon), Oguruma (Civil Works Incense), Otsu Samurai (Prevention), Psyllium , Car forage), toucan thistle (Zhengzhou leakage, bald eagle), toucan Mi (coconut palm), toucan cactus, Ovana okera or okera (white moth), Osana squirrel (Banaba), Ooyabaya shabushi "fruit", Ohitake, Tosushi (cereal essence), Omia catechu, Oha hawthorn or Hawthorn Barley (barley), Oka, Okazeri (snake bed), Okra `` fruit '', Oguruma (overturned), Oguri higotai (Zhengzhou leakage, indigo head), Panax ginseng or Tochibaninjin (carrot), Hypericum pertussis Hypericum pertussis (brother cut grass), Odrichospodium (continuous), Onamomi (amberjack), Onigurumi, Onidokoro or Tokoro or Nagadokoro (hikai), Onyogara (Tempa), Onyuri or Sasayuri or Hakatayuri (lily), Onoelan, Ononis (Kibaba), Ominae (defeated soy sauce), Yuuko, Dutch mustard (Lesson), Dutch jellies, Dutch ville, Dutch honey bees, olives `` fruits, seeds, leaves '', oregano, orange `` fruits, pericarps '', silkworms (ripening yellow), cacao `` fruits, pericarps, seeds '', oysters (柿蒂 `` `` Leaf ''), Kagikazura (Katsufuji 鈎), Kakidooshi or Kantori (Lotus herb), oysters, Gaku hydrangea, Cassia, casino oyster (fruit `` fruit ''), gadget (莪 朮), oak (kaki tree, 槲 葉), Cascarilla, Cascaraca grada, Gypsophila, Kasensou, Crab (Kinshato), Kaniwa, Carnation, Cyprus (Valentine Root), Hippopotamus, Hippopotamus, Birch or Fern birch (Bird), Gerbera, Pumpkin, Kapokoki (Seeds), Kahoku salamander蜀椒), cattail (yellow-yellow), chamomile or Roman chamomile, chamomile (weed), cam cam (camo duck), carraguwa or yamagwa (mulberry moth), camo Rara, Carax salmon man, Crows cricket or Cinnamon cucumber (Wang 瓜), Crow Bishaku (Half summer), Oats, Guarana `` seed '', Calahoo (Koh-Pak), Karaya, Garyu, Karin (Kiso), Garcinia, Kawamidori, Kawara psycho ), Kawadisha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawara Nadeshiko (Soba, buckwheat), Kawaraninjin (blue strawberry), Kawara mugwort (茵? 蒿), Kansui (Akansai), Kanzo (licorice), Kantarasa , Candelilla, canto, canna, kanran, raspberry (Ezo strawberry, Dutch strawberry, shrimp strawberry, nava white strawberry, maple strawberry, European raspberry), kiwi `` fruit, leaf '', kikarasuri (guro-root), kyo-kyo (kikyo, bellflower root), chrysanthemum (Chrysanthemum flower, Shimakangiku, Kyakusengiku), Kikutanikugi, Kisage (Kurumi), Gishigishi (Yotei) Root), pheasant (fruit), kizuta, yellow aloe vera, yellowfin mint, quina, linden (shinkona, red linden), quinoa (quinoa), yellowfin (yellow tuna), yellow bean, kimnema sylvestre, kimenakaku, cabbage, cabbage `` unripe fruit '', character Way, cucumber, gyory (Nishikawa willow, deer willow), Kiraja saponaria, Kiraya, Kiransou (golden grass), kumquat `` fruit '', kinkiju, ginsekai, kimbusen, betel, kinzhiki (Sentsukakusa), quinlan, ginlan, kinryohen , Guapeba vermela, guava `` fruit '', guayule, quellus infectria (galling), kukui nuts, kugenumaran, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, husks), kusasugikazura (tenmon winter), kudzu (kudzu), Camphor, gooseberry “fruit”, carrot, yellow flower Titi River, Gardenia (Mountain Reed), Kunugi (Mountain Sow), Kupuas, Kubeba, Kumazasa, Kumatsutsura (Horse Citrus), Clara (Bitter), Cranberry "Fruit", Chestnut "Seeds, Fruits, Astringent Skin", Curkurigo Latifolia "Fruits '', Grapefruit `` fruit / leaves '', buckthorn, black beetle (rescue necessity), tortoise brackish or black beetle or tocotic (prolonged herb), clove (clove, clove), gumbai tuna (sekimei, budgerigar), keigai , Celosia (chicken crown flower, hen crown), gekkavidin, bay bay (laurel wreath), Kenashi Sartorii rose (Tsumago, mountain return), gentiana, ganoderma (old lady grass), kemponashi (kigushi), kokisekoku, kushimikan (kouji, tachibana, Giant mandarin orange, fukumi mandarin, sagamikoji, ponkan, santara (tachibana )), Koshinbara (monthly flower), Kousuihakka, Kozo `` fruit '', Kocha (tea), Kohone (river bone), Kohon (Kakimoto, Karamoto), Koryang, Koryokyo (Koryo), Koendoro `` fruit '' , Kourien (Huo Ren), Koganebana (Yellow Gon), Cowberry (Etsutachibana), Coco `` Fruits '', Goshuyu (Kureo), Gosho Strawberry (Golden Bonsai), Pepper (Pepper), Cosmos, Copaiba Balsam, Coffee `` Seeds, Leaves '', Kofukisarokoshikake (plum infestation), Kobushi or magnolia (hot pepper), burdock (beef bowl, beef eggplant), kobotanru, sesame (sesame seeds), sesame seeds (genus ginseng), trash beetle (gumiko), sakanekazura or binankazura or pine bush, wheat ( Wheat), rice or rice bran “red cocoon, white birch”, rice oil, cola acminata “seed”, cola vera “seed”, coleus forskori, colony llya, koroha “fruit” `` Fruit '', colombo, konzurango, kombu, konjac, comfrey (candid grass), sisal (sisal asa), rhinoceros, sakaneran (ezosakaneran), saxima button eel or cinnabar bud or cinnamon ginseng (weikensen), sakura (oshima cherry, yamazakura, Oyama cherry, Edhigashi, Bean cherry, Miyaza cherry, Yoshino cherry, Takane cherry, Kasumi cherry, Kohigan, Sato cherry, Kanzakura `` Leaf, flowers, fruit, bark (cherry bark) ''), cherry, pomegranate, Sasa, Sasabaginran, Sasanka, Sasiomodaka , Sweet potato, sugar cane, sugar beet, sunflower jujube (acidic vine), saffron (banban flower, west red flower), sapodilla, sapotea mariyo, pomelo `` fruit '', bonito, salmon berry `` fruit '', salamander ginger, salamander Indigo head), Salvia (sage), Sagaki (mountain curd), Sawagurumi (mountain walnut), Sangaku cactus, Sangre de Grado (croton), Sangakuyosou, Sansinjinjin (Thirty-seven ginseng), Sanshuyu Salamander, Sanzukon (Mamezu), Shia (Kalite), Cyanoki (fruit), Shiitake mushroom, Shion (Shigetsu), Shikakumame, Dikitaris, Sikunshi (Amiko), Perilla or Blue-tailed or Chimmento or Catamendizo (Shiyo leaves, Shisoko), Rosewood, Shinanoki, Shinohonoki, Sinarenkyo (ream), Shimeji (Hinshimeji, Shakashimeji, Hatake-Shimeji, Oshiroi-Shimeji, Buna-shimeji, Honjimeshi, Shirotamogitake), Shimokuren (Shigeki), Shimo-gakuso Glaze), Shajin (Shasan), Jasmine (Matsurika), Janohige (Bakumon Winter), Ju Horseradish, Shukukonkamiso, Shukushamitsu (sand seeds, shredded sand), Juzudama, Shuro `` fruit '', Shunran, Jiaoshui, ginger (ginger), Zhoushan hydrangea (Tsuneyama), shobu (bamboo shoot, root), shozu `` fruit '', Shirakashi `` Seeds '', Silane (Bikkyu), White Rooster butterfly `` Seeds '', White clover (Clover), White clover (chicken bone grass), White squirrels (Nioiris), Shirobanatsuta `` Flowers '', Shirobanarupin, Shirominanten (Southern fruit), Cinchona Sacylbra, Ginkgo biloba (Mizuka, Mika, Shencho), Cinnamon, Cinnamomum cassia (Cinnamon), Watermelon (Sairan), Honeysuckle (Gin silver flower, Shinobi), Sorrel (Acid), Swimberry "fruit", Star apple , Stevia, Strawberry `` fruit '', Suzu-Psycho (Xucho), Sugina (question), Subhihiyu ( Toothpaste, Horse Teeth), Plum `` fruit '', Sulgaran (Oran), Japanese red pine `` Conifer '', Japanese larch, Japanese cypress, Japanese walnut, Japanese hawthorn, Japanese cypress, Japanese dandelion, Japanese horse chestnut (Maroni) Pear `` Fruit '', Eurythus, Elder, Prunus (Juniper, Juniper), Achillea millefol (milfoil), Rose, Pteropus, Mistletoe, Atlantic mint or Papilio, Horseradish, Sekisho (Ishizone), Sekkoku (Sakura Sekkoku, Koki Sekkoku, Obanase Sekkoku, Okinawa Sekkoku, Honsekoku, Kocho Sekkoku, Shika Sekkokuk, Kibanano Sekkoku) (Dendrobium, Shiso), Cedron ), Mallow, Senegal, seri, celery, nematode (river cucumber), senshinren (centripetal ream), sendan, sennin cactus, senna `` fruit, leaf '', sennin (Otsuka), senburi (this drug), senboku , Sowka (grass), Elephant burrow, Sobain baibai, buckwheat `` seed '', Somer potato, broad bean, Daio (daihuang), Japanese radish, soybean, Daidai (orange peel, fruit), Takasagorihigotai (Southeast indigo sashimi), Takasaburo (旱) Lotus), Takatodai (Otsuka), Takarabi (Kashiwaji), dark sweet cherry `` fruit '', hollyhock, hollyhock (thyme, Hyakuka), tachidokoro (hikai), tachiyanagi, tamarind `` seed '', onion, ramshiba (hot pepper) ), Taranoki `` fruit, leaves, root bark '', tarayo (large leaf winter blue, one leaf tea, bitter tea, bitter tea), dahlia (tenji button), tarwi, Nikirimame, tanshichiwa, tanjin (dansang), dandelion (Sanko) or Shirobana dandelion or mouko dandelion, danmaru, cherry `` fruit '', chigaya `` fruit, root, bud '', chikutsuninjin (bamboo ginseng), chicory, chancapiedra (kidachi) (Komikansou), tulip, chokonostay, dungeon thistle (artichoke), ginkgo biloba (large yellow), ginseng (蕪 夷), ginseng (leaf), choreimaitake (bamboo), chorogi, tsukimisakane, tsukushikananeran, tsukuritake ( Mushrooms), camellia, camellia, camellia, clover (lacquered weed), camellia (duck weed), cranberries (red azuki beans), periwinkle, crested duck (what neck rice cake), tuna (apricot apricot), clove carrot (four leaf ginseng), cirrus, Tsuwabuki, Deiko, Teuchigurumi, Duberry "fruit", Tengusa, Tencha (bamboo tea), Tendai-yaku (glaze), Toga (winter lion), Toka moth, pepper, (Toban), Toki (Tokai), Tokinsenka (marigold), Toukachichi, Tounabena (river cut), corn Or corn hair (south cocoon hair), horned potato (Sadako), Torindo or Kyakusen Gindou (dragon gall), Tokusa (wood band), dokudami (ten medicines), Tokon (gush roots), toshi or bean pods `` Bark, leaves, roots ''), ash (crust), tomato, tragacanth, triacanthus `` seed '', truffles (carp), eustoma, tormentilla, dronoki, trorooi, tongamame, nigerian berry `` fruit '', Chinese yam or Yamanoimo (Yakuyaku), Nagiikada (Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Na Beans or vertical blades (sword beans), Natsumikan, jujube (Otsuchi), Naniwaibara (Golden Sakurako), Nabena (continuous), Nameko, peanuts (peanuts), Nanten (Southern fruit), Nanban ramie (Sanma), Niois violet, Nigaki (Nagiki), Nigamugigi (Anniversary), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabu Nikkei (Cinnamon) or Keishi (Katsura), Neem (Indian Sendan), Flyingbird, Nira (lion), Elderberry `` Fruits, flowers, stems, leaves ''), garlic (large persimmon), nulde (pentapolitan), leek, nemno or nebu or nebi or nemlinoki or digokubana (community), white thistle (large persimmon), noibara (fruit), nousenkazura (surpassing flower) ), Nogateto, Yarrow, Nodake (Apricot), Novara, Peach, Pineapple "Fruit", Hibiscus (Bussouge, Furinbusouge, Roselle), Hailin Uh, Hauchiwa, Pau Dorse, Hakamaurabosi (bone crushing), Hakkayumatou, Hakusanchidori, Hakusen (white ring skin), Hakuruberry `` fruit '', Hakobe (breeding), hazel (lion), Hashiridokoro (roth root), basil, Lotus (lotus, lotus, lotus), parsley (holland jellied), hadakamugi, batata, beak or madake (bamboo shoots), patchouli, mint (thin load, light load leaf), ash peas, pearl barley (yokuinin), hanasuge (knowing mother) , Banana, Hana-hakka, Hanabishi (Shitsuri, Shishitsuri), Vanilla Bins, Papaya, Hakogakusa (Paso), Pahalobobo, Hub `` Whole Grass, Stem, Leaf '', Paprika, Hamakakiran, Hamago or Mitsuba Hamago (Vanus) (Katsukiko), Japanese squirrel (Shitsushi), Hermanus (Maika flower), Japanese kingfisher (hama windbreak), Hamamelis, Palm, rose (rose), balata, rose Rubber tree, agaric (Agaric, white-faced agaric, Ukimorimorikasa), Haran, Pariurus (Amanita spp.), Parietalia, Harkanran, Balsamina (Turureishi, Nigauri), Haruni (Chibern, cinnabark, coconut leaf), Barbasco, Harlindow, Handikai (Saikai Sea), Pannoki, Hinogi (Shikan), Hikageturinjin (party participation), Pecan nuts, Japanese squirrels (Ishizuchi, Buddha Shahua), Hygurmadaria, Higotai, Hishi (Hishimi), Pistachio, Beet, Hitsuba ( Sarcophagus), Hitsubei fern, daisies (Daisy), chicktail (Chinese knee), chickweed, cypress, hiba, castor, sunflower, green pepper, Himezu (Tengu), Himamatsu (Koh), Himatsutake (Harimatsutake, Hiromatsutake) Himemuyoran, pimenta "fruit", peony, beakkyu, jade Fruits, chickpeas, lentils, bellows, oysters (bald eagle), loquat (fruits, leaves, stems), betel nuts (large clothes, coconuts), puer tea, sweet peas (southern rattan), fuki, fukidanpopo , Fuji Fubakama (Orchid), Fuji Bean (Tanzu), Fujimodoki (Chojizakura, Spike), Grapes `` Fruits, Pericarp, Seeds, Leaves '', Beech, Fuyushinatsusatake (Chinese Cordyceps), Brazilian Licorice, Brazilian Carrot, Brazil palm, Brazilian elephant palm, black currant `` fruit '', blackberry, brunnen, plum `` fruit '', fullceraria, blueberry (Prunus japonica), prune, floral blanka, blond psyllium, bundo (mung bean), hazelnut, loofah , Hetsukaran, safflower (Safflower), Henken, Belladonna, Berry , Persea, Pervianberg, Pereschia grandifolia, red beetle or duckweed (scenic sky), boysenberry `` fruit '', scallops or narcissus or nendo or hahagigi kokia (skin larvae), horsiran, scallop (Bone bone), powteria sapota, pouteria lukuma, spinach, spinach, physalis (Torne), honoki (Japanese rustic, magnolia), bokeh (wooden mushrooms), hosobaabragiku (tasteyoku), hosobaoguruma, hosobanaokera (蒼朮), Buttercups (Keiten), Buttons (peony `` flowers, leaves, stems, bark ''), Buttonpi (peony peels), Hops, jojoba, Borigi (Lurichisha), Bordeaux, Hower Torberry "fruit", Hononiku (meat jugo, Daiki), Honsecek (iron skin stone, sparrow mountain stone candy), Mizuru Tenna Panax (Tennan Star), Maitake (Maiko), Maou (Mao), Maca, Macadamia Nuts, Margaret (Mokushungiku), Macri (European Grass), Magwa (Mulberry White Bark “Bark, Leaves”), Magnolia Sprengeri, Mazaran Mouba , Masalanzuba de Cearer, Masheira de Boi, Mashua (Tamanozen Hallen, Kyukon Kinlenka), Matatabi (Mushroom Tendon), Matsukasa, Pine "Leaf, Bark, Root", Matta Oryo, Matsutake (Matsutake) , Matsuhodo (茯苓), Matico (Cordon Shijo), Mayoram (Hanahakka), Malvano Jazine (Bitter), Mulberry `` Fruit '', Quince, Malene (Bilaud Muzuika), Mango, Mangosteen, Manzanya (Andesca Mitsule), Manshugurumi, Mandarin `` fruit '', Mannentake (reishi), pheasant (fruit berries `` fruit ''), Mishima psycho (Shibako) Japanese giant plantain or Japanese morning glory (Dragongrass), Mizokakushi (half-sided lotus), Misohagi (Chinese cypress), Japanese willow or Japanese willow (Henpo), Japanese oak, Mitsuba, Midorisapotate, Midorihakka, Mimosa, Miyuga, Miracle fruit `` Fruit '', Myrrh , Myrobalan, wheat straw, mugwort, mugwort, mugwort (prolonged skin), munya, murasaki (purple), murasakikibu or oomurasakikibu (purple pearl), murasaki corn, murasaki kinfuji (Kunming chicken blood wisteria), megakansa opuntica , Meshimakobu (mulberry yellow), Japanese reptile (benus), Mebogi, Japanese evening primrose (Evening primrose), Melaleuca, Melissa, Melilot, Melon `` fruit '', Moukomugi, Mosouchiku, Mokkirin, Mogi (Pepper), Mochinoki, Mokko Japanese maple, peach (peach, leaf, seed, flower, fruit )), Sprout, Morello cherry `` fruit '', Morohaya (yellow burlap), Yakawamura potato, Yakuchi (Michichi), Yakuyo garage, cornflower (cornflower), cornflower mint, yacon, Yaba santa, Yashabushi or Himeya sabushi `` Fruits, pericarps, fruit ears '', willow willows, starfish (octagonal gold plate), mistletoe (willow infestation), willows (kawayanagi, tachiyanagi, weeping willow, akame willow, cat willow, incolyana, kinuyanagi, koryanagi, unryu willow, willow, willow (Wolf willow, Tairikukinu willow, Fox willow, Dronoki), Yanagita `` leaves, stems '', Yaba Santa, Yabugarashi, Yabukouji (purple gold beef), Yabu tobacco (Tsuruga, Tensei), Yamagobo (Shoku land), Yamadoritake (Porcini, Cep, Stein (Piltz), Yamahanoki (Yamamuro), Yamamomo (Yamamushi), Yamamomogi, Eucalyptus, Yukinoshita (tiger ear grass), Yucca or flevifolia, Yuzu `` fruit '', Lily, Yorigusa, Mugwort (Leaf), Ligan (Raimaru), Lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaves, fruit '', latania (chlamellia), rakkyo or shallot (palm white), lavender, longan (long-eyed meat), agave (Aonorus agave, fuchlin agave), ryokucha (green tea) ), Apples `` fruit, seeds, leaves, roots '', gentian, lubas or suabisimus (cool), rulitama thisami (cold tiger tiger, new lantern head), litchi (toothpick, toothpick), lettuce (chisha), red car Land “fruit”, red pitaya, lemon “fruit”, lemongrass, forsythia or syringa (ream), Gesou, wintersweet, wax palm, locon (yoshi, sone), Logan berry `` fruit '', rosemary (mannenrou), rose hip (novara), wasabi, cotton wisteria (mongmond flower), walmokou Etc.

  As seaweeds, seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), Anaaosa (Aosa)] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Neocitus Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etsumi Uchiwa], seaweed [Red algae: Hijirimen, Maca (Tengusa), Hiraksa, Syria, Oaxa Caterpillar, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper ginkgo rhinoceros, Tsunomata, Totsuka (Yahazutsu notamata), Ezotsunotamata, Togetu no Takita , Yaleus banori, Kagius banori, Susius banori, Haius banori, Akamo mizunori] and the like.

  In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kuwanomimo: Kuwanomimo, Volbox: Ohigegawa, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Hitogususa genus: Humanegusa, Hirohatohigususa, Umushihimoe, Sakikimoe Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).

  Cyanobacteria (Suizenjinori: Suizinori, Aoko, Nenju: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.

  Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozuku, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: lobster, genus genus: yokojimamanori, Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Ukimo: Ouokimo, Burukimo: Burukimo, Kayamonori: Kayamonori, etc.).

  Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobasho: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haezaki Sawflower, Kawamoku : Kawamoke, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okichizu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).

  Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotumusu, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.

  In addition, the materials derived from animal materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig brain tissue Extracts, cattle / pigs / fish collagen hydrolyzate (acid, alkali, enzyme etc.) degradation products, water-soluble collagen or collagen derivatives such as acylated collagen, cattle / pigs / fish elastin or elastin hydrolyzate (acid, Alkali, enzyme, etc.) or water-soluble elastin derivative, wool or feather keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or cow blood cell protein degradation product (globin peptide), cow Or porcine hemoglobin degradation product (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or derivatives thereof, skim milk powder and its Hydrolyzate or a derivative thereof, lactoferrin or a degradation product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.

  In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, etc. derived from a gene recombinant or a cell fusion can be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.

(14) Marine components Seawater such as deep seawater, for example, sea salt, dried seawater, inorganic salt (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (from the Dead Sea or Atlantic Ocean) Fango), for example, Italian mud, German fungo, Eifelfango, Freiburg fungo, etc. Sea mud or mud from various locations (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, Magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, black meteorite, etc.

(15) Microbial culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermentation extract , Fermented rice bran (red rice bran, white birch) extract, Euglena extract or decomposition product thereof or water-soluble derivative thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, fermented lactic acid bacteria of legumes, coconut plant Lactic acid bacteria fermented products.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, Bengala, black iron oxide, gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.

(18) UV absorber / blocker benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxy Dimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, Octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxycinnamic acid cinnamate) Til, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, Methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative Body, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin etc.

(19) Whitening agent Paraaminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, pearl oyster, clam, clam, mugwort, honeysuckle) , Kihada, dokudami, matsuhod, pearl barley, nettle, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamamelis, karagua or yamagwa, life-prolonging grass, bellflower, toshishi, zetsugo, gyu, mao, sen Oxalic, Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(21) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether).

(22) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, Ogon, Japanese horsetail, Gentian, Burdock, Shikon, Carrot, Camelis, Hop, Yokuinin, Odori, Semburi, Japanese cypress, Japanese red snapper, Achacha, Hypericum, Cucumber, Necklace, Mannenrou, Parsley).

(23) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds) and the like.

(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidants Vitamin C or salts thereof, stearic acid ester, vitamin E or derivatives thereof, nordihydrogua cetelenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole , Propyl gallate, sesamol, sesamorin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame culture cell, hamcha, hypericum, hamamelis, clove, melissa, birch, birch, salvia, mannenro, minamitenji, agetsu, ginkgo, green tea).

(27) Anti-inflammatory agents Allantoin, azulene, guaiazulene, camazulene, ictamol, indomethacin, ε-aminocaproic acid, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, malein Acid chlorpheniramine, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract, propolis, etc.

(28) Antibacterial / bactericidal / disinfectant Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, Sarashi flour, iodine compound, iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, resorcin, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, 2 , 2,4-Trichloro-2-hydroxyphenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halo Carban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (Polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (brominated Cetyltrimethylammonium, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, briria Togreen, Malachite Green, Crystal Violet, Jamal, Photosensitive Element 101, Photosensitive Element 201, Photosensitive Element 401, N-Long Chain Acyl Basic Amino Acid Derivatives and Acid Additive Salts, Zinc Oxide, Hinokitiol, Kudin, Propolis, etc. .

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or Derivatives or chitosan derivatives, pyrrolidone carboxylic acid or salts thereof, sodium lactate, urea, sorbitol, amino acids or derivatives thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine , Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates Phosphate, nitrate, citrate, or pyrrolidone carboxylic acid), oils and fats “Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil , Cucumber oil, beef tallow fatty acid, quince seed oil, cucumber seed oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil , Peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, coconut oil, eucalyptus oil, beef tallow, squalene, squalane, pristane or hydrogenated products of these oils and fats ( Hardened oil) ”, waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lath Norin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), sphingolipid (ceramide, sugar ceramide, ceramide phospholipid, etc.), Bacillus natto Metabolites, natto extract, silk fiber extract, plant extract (red pine sap, aloe, kudzu, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assembly, mulberry bark, birch leaf, Loofah, peony skin, candy) etc.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (eg, gongoid, hypericum, clara, mulberry leaves, keihi, genokosho, comfrey, salvia, elderberry, bodaiju, button pie), seaweed extract and the like.

(31) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, thio Glycolic acid and the like.

(32) Antiandrogens Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, etc.

(33) Peripheral vascular blood flow promoter Vitamin E or derivatives thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitive element 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(36) Antiseborrheic agent Pyridoxine or its derivatives, sulfur, salicylic acid, resorcin, vitamin B6, benzalkonium chloride, benzethonium chloride, halocarban, 2,4,4-trichloro-2-hydroxyphenol, and the like.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent Hydrogen peroxide water, formic acid, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrophosphate peroxide Sodium phosphate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(39) Hair remover Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate) Strontium thioglycolate) and the like.

(40) Hair swelling agents such as ethanolamine, urea and guanidine.

(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, paraphenylenediamine, paramethylamino Phenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N -Phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diamino sulfate Diphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, parasulfate sulfate Methylaminophenol, metaaminosulfate Diol, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfone Sodium acid, hematein, etc.

(42) Fragrance Natural animal fragrance such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, Cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot Spirit , Peru balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannenrou) essential oil, Japanese mint mint essential oil Other synthetic fragrances.

(43) Dye and Colorant Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye, Onion Dye , Tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.

(44) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(45) Nutritional enhancer Shell-calcined calcium, cyanocolabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(46) Dairy products Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.

(44) Others Hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and vegetable polysaccharides And its degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound treatment agents, foam increasing agents, thickeners, enzymes, purified water (electronic Water, small clustering, etc.), oral preparations, deodorizing / deodorizing agents, bittering agents, seasonings, etc., and in combination with these, additive or synergistic effects of the present invention or other cosmetic effects Improvement can be expected.

[Production example]
Hereinafter, production examples will be described, but the present invention is not limited thereto.

(Production Example 1)
Add 40 times the amount of purified water to 100 g of seaweed alga mixture consisting of Trollo Kombu, Mitsushi Kombu, Resilib, Wakame, Giant Kelp, Hibamata, Ascophyllum dosum, and HIKIKI, soak for 24 hours with occasional stirring, and filter As a result, about 3.8 kg of an extract (dry solid content: about 0.7 to 1.2%) was obtained.

(Production Example 2)
Add 10 times the amount of 50% ethanol solution to 100g of a mixture of three or more seaweeds selected from Trollo Kombu, Mitsushi Kombu, Macombu, Resilib, Ainu Wakame, Wakame, Giant Kelp, Hibamata, Ascophyllum dosum, and Hijiki The sample was immersed for 7 days with occasional stirring and filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.8 to 1.4%).

(Production Example 3)
(A) at least one kind of seaweed selected from Trollocomb, Honeycomb, Macombu, Resilib, Ainu Wakame, Wakame, Giant Kelp, Hibamata, Ascophyllum dossum, and hijiki, and (B) Bikkushinkirin, Kirinsai, Tosakanori, Mirin, Algae with one or more kinds of seaweed selected from Shikinori, Suginori, Kotojitsu no Mata, Uchiwatsu no Mata, Tsuno Mata, Mukadenori, Fudaraku, Hijirimen, Tengusa, Ogonori, and (C) One or more kinds of seaweed selected from Aosa, Usubaaoori, Susioonori Add 12 times 50% 1,3-butylene glycol solution to 100 g of body (A) (B) (C) mixture, soak for 7 days with occasional stirring, filter and extract (dry solids: approx. About 1.0 kg of 0.7-1.2%) was obtained.

(Production Example 4)
Toro Kombu, Mitsushi Kombu, Macombu, Risilibu, Ainu Wakame, Wakame, Giant Kelp, Hiba Mata, Ascophilum Nodsum, Hijiki, Binki Shinki Rhinoceros, Giraffe Rhinoceros Transfer to 100 g of a mixture of three or more seaweed alga bodies selected from Hijirimen, Proboscis, Ogonori, Aosa, Usba Aonori, Susiaoonori, respectively, and extract to 150 kg / cm ² , separation pressure 40 kg / cm ² , temperature 45 ° C Supercritical extraction was performed by supplying carbon dioxide in a supercritical state to obtain 0.92 g of a supercritical extract.

(Production Example 5)
(A) at least one kind of seaweed selected from Trollocomb, Honeycomb, Macombu, Resilib, Ainu Wakame, Wakame, Giant Kelp, Hibamata, Ascophyllum dossum, and hijiki, and (B) Bikkushinkirin, Kirinsai, Tosakanori, Mirin, Algae with one or more kinds of seaweed selected from Shikinori, Suginori, Kotojitsu no Mata, Uchiwatsu no Mata, Tsuno Mata, Mukadenori, Fudaraku, Hijirimen, Tengusa, Ogonori, and (C) One or more kinds of seaweed selected from Aosa, Usubaaoori, Susioonori Ten times the amount of 1% 1,3-butylene glycol solution is added to 100 g of each of the body (A), (B), and (C) mixtures, heated at about 80 ° C., and filtered. 1,3-butylene glycol is added to the filtrate so that the concentration becomes 10%, and the mixture is left standing in a cool and dark place for one day and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.6 to 1.3%).

(Production Example 6)
Toro Kombu, Mitsushi Kombu, Macombu, Risilibu, Ainu Wakame, Wakame, Giant Kelp, Hiba Mata, Ascophilum Nodsum, Hijiki, Binki Shinki Rhinoceros, Giraffe Rhinoceros Add 20 liters of 40% 1,3-butylene glycol solution to 10 kg of a mixture of three or more seaweeds selected from hijirimen, proboscis, ogonori, aosa, usba aonori and sujiaoori, soak for 10-15 days, and then centrifuge. . Add 20 L of 20% 1,3-butylene glycol solution to the residue and immerse and separate in the same manner. Combine both extracts and let stand in a cool dark place for 7-10 days, then filter. To this, 1,3-butylene glycol solution was added to 45% and aged for about 1 month to obtain about 50 kg of an extract (dry solid content: about 1.0%).

[Test 1] Test of promoting proliferation of hair papilla cells The proliferation action on rat eyelash papilla cells was evaluated.
(Test method)
Toyobo and rat eyelash papillary cells (TRPC-001) were used, suspended in 10% FBS / DMEM at a concentration of 1 × 10 ⁴ cells / mL, seeded at 0.2 mL / well in a collagen-coated 96-well plate at 37 ° C. Pre-culture was performed in a CO ₂ incubator for 24 hours. Thereafter, the medium was replaced with DMEM to which each sample was added to a final concentration of 1 ppm, and the culture was further continued for 6 days. After completion of the culture, the number of cells was calculated using a cell counting kit from Dojin Chemical. The results are shown in Table 1.

(sample)
Seaweed described in Table 1 was mixed at various mixing ratios, 35 times the amount of purified water was added thereto, immersed for 24 hours with occasional stirring, and filtered to obtain an extract. This was appropriately diluted and used for the test. Purified water was used as a comparative example.

<Table 1>

(Test results)
As shown in Table 1, three or more kinds of seaweed extracts selected from the family Kombuidae, Chigaisoidae, Lessoniaceae, Hibamata, Hondara, Mirinaceae, Sugiori, Muchadenori, Probosidae, Ogonori, Ausa A hair dermal papilla cell growth promoting effect was observed in this mixture. In particular, an excellent effect was observed in the seaweed extract mixture of the Kombu family, Chigaiso family, Lessonia family, Hibamata family, and Honda wallaceae. Therefore, it is considered that the product of the present invention is useful as a hair growth / hair nourishing agent.

(Manufacture example) Manufacture of various compositions According to said evaluation result, although the prescription example is shown below, each prescription example may be manufactured by the conventional method in manufacture of each product, and showed only the compounding quantity. The present invention is not limited to these.

(Formulation example 1) Scalp milk mass%
1.Squalane 5.0
2.Olive oil 5.0
3. Jojoba oil 5.0
4.Cetyl alcohol 1.5
5. Glycerin monostearate 2.0
6.Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) soorbitan monooleate 2.0
8.1,3-Butylene glycol 1.0
9.Glycerin 2.0
10. Seaweed extract from Production Example 1
11. Preservative (paraoxybenzoic acid ester) appropriate amount
12.Perfume appropriate amount
13. Residue with 100 purified water

(Prescription Example 2) Scalp oil mass%
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Seaweed extract from Production Example 2 3.0
6. Seaweed extract of Production Example 4 3.0
7. Grapefruit fruit or leaf hot water extract 1.0
8. Tochu Nakaba Hot Water Extract 1.0
9. Soybean seed hot water extract 1.0
10.Olive oil 1.0
11. Shea fat 1.0
12.Butylhydroxyanisole 0.1
13. Vitamin E derivative 0.1
14. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
15. Perfume (rose water) appropriate amount
16.Residue with 100 purified water

(Prescription example 3) Scalp lotion
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. Seaweed extract of Example 8 2.0
6. 30% yam peel or fruit 1,2-pentanediol extract 1.0
7. Antibacterial (Lactoferrin solution) appropriate amount
8. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
9. Fragrance (Western light load water) appropriate amount
10. Residue with 100 purified water

(Formulation Example 4) Astringent lotion
1.Sorbit 2.0
2.POE (20) oleyl alcohol 1.0
3.Ethanol 15.0
4.1,2-Pentanediol 3.0
5. Seaweed extract of Example 12 3.0
6. Gentian whole plant 50% ethanol extract 2.0
7. Yam peel or fruit 30% ethanol extract 1.0
8. Cucumber fruit 50% propylene glycol extract 1.0
9. Yeast 50% 1,3-butylene glycol extract 1.0
10.Allantoin 0.2
11. Astringent (Zinc Sulfocolate) 0.2
12. Antibacterial / preservative (thiamin lauryl sulfate) appropriate amount
13. Perfume (lavender water) appropriate amount
14. Residue with 100 purified water

(Prescription Example 5) Two-layer lotion (liquid to liquid type)
1. Squalane 8.0
2.POE sorbitan tetraoleate 0.3
3. Sorbitol 1.0
4.Ethanol 15.0
5. Seaweed extract of Example 11 3.0
6. Clam leaf 70% propylene glycol extract 3.0
7. Oolong tea leaves or stems 70% ethanol extract 2.0
8. Acacia rhizome or root bark 50% propylene glycol extract 2.0
9.Ascorbic acid glucoside 0.2
10. Astringent (calamine) 0.1
11. Antibacterial / preservative (phenoxyethanol)
12. Fragrance (apple water) appropriate amount
13. Residue with 100 purified water

(Formulation Example 6) Carmine lotion (liquid to solid) mass%
1.Glycerin 3.0
2.1,3-Butylene glycol 5.0
3.Ethanol 15.0
4. Iron oxide (Bengara) 0.2
5.Zinc oxide 0.5
6.Kaolin 2.0
7. Mitsushi Kombu 30% propylene glycol extract 3.0
8. Hibamata 50% propylene glycol extract 3.0
9.Hijiki 50% propylene glycol extract 2.0
10. Usenia mallow flower or leaf 50% propylene glycol extract 2.0
11. Chamomile flower 50% propylene glycol extract 2.0
12. Comfrey leaves and stems 50% ethanol extract 1.0
13. Fuquitan poppo flower or leaf 50% 1,3-butylene glycol extract 1.0
14. Porcine placenta enzymatic solution 1.0
15. Silk protein alkaline solution 2.0
16.Camphor 0.2
17.Phenol 0.03
18. Antibacterial and antiseptic (photosensitive element 201 & 401) appropriate amount
19. Fragrance (Bodhi Tree Water) Appropriate amount
20.Residue with 100 purified water

(Formulation example 7) Pack mass%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
5. Seaweed extract from Production Example 5 5.0
6. Ginseng root 30% ethanol extract 1.0
7. Stem or leaf 30% ethanol extract 1.0
8. Wenzhou tangerine peel 50% 1,3-butylene glycol extract 1.0
9.Green tea leaf hot water extract 1.0
10.Peach leaf hot water extract 1.0
11. Yeast 50% 1,3-butylene glycol extract 1.0
12. Pig placenta hot water extract 1.0
13. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
14. Fragrance (rose water) appropriate amount
15. Residue with 100 purified water

(Formulation example 8) Emollient cream mass%
1.Stearic acid 2.0
2. Stearyl alcohol 7.0
3.Reduced lanolin 2.0
4.Squalane 5.0
5. Octyldodecanol 6.0
6. Polyoxyethylene cetyl ether (25E.O.) 3.0
7. Lipophilic glyceryl monostearate 2.0
8.Propylene glycol 2.0
9.1,2-Pentanediol 2.0
10. Seaweed extract of Production Example 3 1.0
11.Glycyrrhetinic acid 0.1
12. Pig Placenter Enzymatic Decomposition Solution 1.0
13. Antibacterial (Lactoferrin solution) 0.5
14. Antibacterial and antiseptic (zinc pyridione) appropriate amount
15. Fragrance (mugwort water) appropriate amount
16.Residue with 100 purified water

(Formulation example 9) Facial cleansing cream mass%
1.Stearic acid 10.0
2.palmitic acid 10.0
3.Myristic acid 12.0
4.Lauric acid 4.0
5.Glycerin 18.0
6. dl-Pyrrolidonecarboxylate sodium solution 1.0
7.Dioctyl adipate1.0
8.Cetostearyl alcohol 3.0
9.Triethanolamine 3.0
10.Ergocalcifer 1
11.Oleyl alcohol 1.5
12. Lanolin derivative (EO adduct) 1.0
13.Potassium hydroxide 6.0
14. Seaweed extract of Production Example 6 5.0
15. Royal Jelly Extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
16. Oil-soluble chamomile flower or leaf extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
17. Oil soluble licorice root or rhizome extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
18. Edetate 1.0
19.Glycyrrhizic acid 1.0
20.Corn cob grain 0.1
21. Teut Walnut Shell Grain 0.1
22. Antibacterial and antiseptic (photosensitive element 401) 0.1
23. Fragrance (mugwort water) appropriate amount
24. The balance of 100 purified water

(Prescription Example 10) Shampoo Mass%
1.Lauryl sulfate triethanolamine 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-Butylene glycol 4.0
4.Lauric acid diethanolamide 2.0
5. Edetate disodium 0.1
6. Seaweed extract of Example 4 3.0
7.Hyperum root bark or rhizome hot water extract 2.0
8. Spike or rhizome 30% 1,4-butylene glycol extract 2.0
9. Toki 30% 1,4-butylene glycol extract 2.0
10. Tomato fruit hot water extract 1.0
11.Hydroxypropyl chitosan solution 1.0
12. Hyaluronic acid solution 1.0
13.Dipotassium glycyrrhizinate 0.1
14. Antibacterial and antiseptic (photosensitive element 101) appropriate amount
15.pH adjusting agent
16. Fragrance (white sand water) appropriate amount
17.Residue with 100 purified water

(Prescription Example 11) Rinse mass%
1. Stearyltrimethylammonium chloride 2.0
2.Cetostearyl alcohol 2.0
3.Polyoxyethylene lanolin ether 3.0
4.Propylene glycol 5.0
5.Ethylene glycol 3.0
6. Seaweed extract of Example 10 5.0
7. Soybean leaves 50% 1,3-butylene glycol extract 1.0
8. Western bodhi tree flower or fruit 50% 1,4-butylene glycol extract 1.0
9. Olive leaf 50% 1,2-butylene glycol extract 1.0
10. Muggei fruit or flower 50% 1,3-butylene glycol extract 1.0
11. Sweet tea whole plant 50% glycerin extract 1.0
12.Bifidobacterium fermentation broth 1.0
13.Sodium alginate 1.0
14. Trehalose solution 1.0
15. Hydrolyzed keratin solution 1.0
16. Antibacterial / preservative (benzalkonium chloride) appropriate amount
17. Fragrance (camomile water) appropriate amount
18.Residual water 100

(Prescription Example 12) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Triethanolamine 1.0
5. Seaweed extract of Example 3 3.0
6. Hop female flower ear 50% ethanol extract 1.0
7. Melissa whole plant 50% ethanol extract 1.0
8. Usbasaicin rhizome 30% ethanol extract 1.0
9. Birch sap 1.0
10.Carpronium chloride 0.3
11. Hinokitiol 0.5
12.Keratin degradation solution 0.5
13. Stearyl glycyrrhetinate 0.1
14. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
15. Fragrance (rose hip water)
16.Residue with 100 purified water

(Formulation example 13) Hair artnic mass%
1.Ethanol 40.0
2.Ethyl oleate 1.0
3.Polyoxyethylene (40) hydrogenated castor oil 2.0
4. Seaweed extract of Example 1 3.0
5. Seaweed extract of Example 5 1.0
6. Antibacterial and preservative (propyl paraoxybenzoate) 0.2
7. Residue with 100 purified water

(Formulation example 14) Hair artnic mass%
1. l-Menthol 0.2
2.Ethanol 32.5
3.Polyoxyethylene hydrogenated castor oil 0.5
4.Propylene glycol 5.0
5.Diphenhydramine hydrochloride 0.3
6. A: Trollocomb water extract B: Mitsushi Kombu water extract C: Resiquib water extract D: Wakame water extract E: Giant kelp water extract F: Hibamata water extract G: Ascofilum nodsum water extract H: Hijiki Water extract I: Juniper ginkgo rhinoceros water extract J: Giraffe rhinoceros water extract K: Millin water extract L: Shikinori water extract M: Suginori extract N: Kotojitsu no mata water extract O: Tsunomatsu water extract P: Mucadenoli water extract Liquid Q: Fudaraku water extract R: Hydirimen water extract S: Propaganda extract T: Ogonori water extract U: Aosa water extract V: Usubaaonori water extract W: Sueaonori water extract * A to W 3 or more seaweed extracts 2.0
7. Hypericum fruit or pericarp hot water extract 1.0
8. Western bodhi tree flower or leaf 50% propylene glycol extract 1.0
9. Lavender flower or flower ear hot water extract 1.0
10. Belode oyster rhizome or root bark 50% ethanol extract 1.0
11. Ogon rhizome or root bark 50% ethanol extract 1.0
12.Carboxymethylchitin solution 1.0
13.Cow crown extract solution 0.2
14. Panthetin aqueous solution 0.2
15. Antibacterial / preservative (phenoxyethanol)
16. Perfume (rose water) appropriate amount
17.Residue with 100 purified water

(Formulation Example 15) Hair growth / hair growth agent
1.Ethanol 60.0
2. Seaweed extract of Example 2 5.0
3. Dior rhizome 50% ethanol extract 2.0
4. Vitamin E derivative 0.5
5.Pepper tincture 0.5
6.Resorcin 0.5
7.Dipotassium glycyrrhizinate 0.5
8.Carboxymethylchitin solution 0.5
9. Collagen protein enzyme solution 1.0
10.Pig hematin solution 0.5
11. Porcine mucin solution 0.5
12. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5
13. Antibacterial and antiseptic (paraben) 0.1
14. Fragrance (rosemary water)
15. Residue with 100 purified water

(Formulation Example 16) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 5.0
4. Seaweed extract dry powder of Production Example 4 5.0
5. Sorbitol 1.0
6. Peach leaf 70% ethanol extract dry powder 1.0
7. Black tea leaf 30% ethanol extract dry powder 1.0
8. Pigment (Gungjo Green) appropriate amount

(Prescription Example 17) Hair Protective Coating Protective Agent A gauze or liniment cloth is impregnated with a prescription solution in which an appropriate amount of seaweed extract, antibiotics, anti-inflammatory agent, etc. of Production Example 1 is mixed and attached to the wound. Alternatively, the seaweed extract of Production Example 1 may be directly sprayed locally and covered with gauze or the like.

Claims (4)

It is characterized by containing three or more kinds of seaweed extracts selected from the family Kombu, Tigaiso, Lessonia, Hibamata, Hondara, Mirin, Suginotori, Mukkadenori, Tengusa, Ogonori, Aoshia Hair papilla cell growth promoter. 2. The hair papilla cell growth promoter according to claim 1, wherein the seaweed extract contains a seaweed extract comprising the family Kombuaceae, Chigaisoaceae, Lessoniaceae, Hibamata, and Honda. The hair papilla cell growth promoter according to claim 1, wherein the seaweed extract contains a seaweed extract comprising the following (A), (B) and (C).
(A) One or more seaweed extracts selected from the family Kombu, Tigaiso, Lessonia, Hibamata, Hondawala,
(B) One or more kinds of seaweed extracts selected from the family Milinaceae, Sugioriaceae, Muscadenoriaceae, Probosidae, Ogonoriaceae,
And (C) one or more seaweed extracts selected from the heronaceae A hair-growth / hair nourishing agent characterized by containing one or more selected from the dermal papilla cell proliferation promoter according to claims 1 to 3 as an active ingredient.