JP4544500B2 - Hyaluronic acid synthesis accelerator - Google Patents

Description

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（処方例２９）被覆保護剤
ガーゼ又はリニメント布にオクラ熱水抽出液及び水溶性β-1,3-グルカン誘導体、抗生物質、抗炎症剤等、適量を混合した処方液を含浸させ、外傷部に添付する。又、オクラ熱水抽出液及び水溶性β-1,3-グルカン誘導体を直接、局所に散布し、ガーゼ等で被覆しても良い。
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（試験６）使用効果試験
上記の処方例の化粧料組成物を実際に使用した場合の効果について検討を行った。使用テストは健康な成人女性２５〜５０歳の１０名をパネラーとし、毎日、朝と夜の２回、洗顔後に処方例１の乳液の適量を顔面に３ヶ月に渡って塗布することにより行った。尚、対照には、乳液から各種天然由来成分を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表２の通りで表中の数値は人数を表す。尚、使用期間中に皮膚の異常を訴えた者はなかった。
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「肌の張り・ツヤ改善効果」
有 効：肌の張り・ツヤが増した。
やや有効：肌の張り・ツヤがやや増した。
無 効：使用前と変化なし。
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（試験結果）
表２の通り、各種天然由来成分を配合した乳液は、有意に肌の張り・ツヤを与え、又、肌のシワ軽減等の効果を有することが確認できた。
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（試験７）使用効果試験
上記の処方例の食品を実際に使用した場合の効果について検討を行った。使用テストは健康な成人女性２５〜５０歳の１０名をパネラーとし、毎日、朝と夜の２回、処方例３５のパン１個（１回約50g）を１ヶ月に渡って飲食してもらった。尚、対照には、パンから各種天然由来成分を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表３の通りで表中の数値は人数を表す。尚、使用期間中に皮膚の異常を訴えた者はなかった。
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「肌の張り・ツヤ改善効果」
有 効：肌の張り・ツヤが増した。
やや有効：肌の張り・ツヤがやや増した。
無 効：使用前と変化なし。
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（試験結果）
表３の通り、各種天然由来成分を配合したパンは、有意に肌の張り・ツヤを与え、又、肌のタルミも軽減することが確認できた。
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【発明の効果】
本発明のオクラ抽出物、水溶性β-1,3-グルカン誘導体は、安全性が高く、ヒアルロン酸合成を有意に促進することが確認された。更に、これらを配合した化粧料組成物や飲食品は肌に対して、張りやツヤの付与、又はシワやタルミの改善といった皮膚老化防止効果を有する。
【図面の簡単な説明】
【図１】本発明のアロエ抽出物、オクラ抽出物、水溶性β-1,3-グルカン誘導体及び酵母抽出物のヒアルロン酸合成促進率を示す図である。[0001]
BACKGROUND OF THE INVENTION
This invention provides the hyaluronic acid synthesis promoter which uses a natural origin substance, its derivative (s), or its decomposition product as an active ingredient, and the cosmetic composition or food / beverage products which mix | blended it.
[0002]
[Prior art]
Typical changes in the aging of human skin are wrinkles and tarmi, which is one of the major skin problems for older people and women. However, at present, there are few effective treatments for skin wrinkles and tarmi, and various studies on aging have been conducted in the aging society.
[0003]
At present, the formation of wrinkles and tarmi on human skin is thought to be caused by a decrease in skin elasticity, which includes aging, drying, oxidation, and the effects of sunlight (ultraviolet rays). Specific histological phenomena include changes in extracellular matrix components such as collagen, elastin, and glycosaminoglycans in the dermis. Among these glycosaminoglycans, hyaluronic acid is widely distributed in connective tissues. It is known as a high molecular weight polysaccharide that retains a large amount of moisture in the skin and has a gel-like form. Therefore, qualitative and quantitative reduction of hyaluronic acid is considered to be important in skin aging.
[0004]
[Problems to be solved by the invention]
  Therefore, the present inventionThe purpose is to develop a hyaluronic acid synthesis accelerator effective in promoting the synthesis of hyaluronic acid.
[0005]
[Means for Solving the Problems]
  In view of such circumstances, the present inventors set the theme of development of a useful naturally-derived component having a hyaluronic acid synthesis promoting action, and as a result,It was confirmed that the okra extract and the water-soluble β-1,3-glucan derivative significantly promote hyaluronic acid synthesis. Therefore, the present invention has been completed by providing a novel and safe hyaluronic acid synthesis accelerator.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
  “Okra” used in the present invention is a plant of the family Malvaceae, Abelmoschus: flowers, spikes, spikes, and peels of okra “Abelmoschus esculentus (L.) Moench (= Hibiscus esculentus L.)” Fruits, stems, leaves, branches, branches and leaves, roots, rhizomes, root barks, seeds or whole plants are used, and fruits are particularly preferable. In addition, the same genus species (A. tuberculata), troro-aoi (A. manihot (L.) Medik. (= Hibiscus manihot L.)), troro-aoi modo (A, moschatus Medik. (= Hibiscus abelmoschus L.)) or these Variants and hybrids can also be used.
[0008]
  The “water-soluble β-1,3-glucan derivative” used in the present invention is a low-molecular oligomer obtained by hydrolyzing β-1,3-glucan to make it water-soluble, β-1,3-glucan or its At least one chemical modification means among hydroxyethylation, hydroxypropylation, carboxymethylation, sulfate esterification, and phosphate esterification for the hydroxy group (-OH) released on the molecule of the low-molecular oligomer Is a compound in which a water-soluble functional group is introduced. The β-1,3-glucan contains β-1,3-linked glucopyranose as the main chain, and contains β-1,6 or β-1,4-linked glucopyranose as the side chain. There is no problem. For example, cell walls of yeast (genus Sacharomyces), curdlan produced by microorganisms such as Alcaligenes faecalis var.myxogenes and Agrobacterium, paramylon produced by Euglena protozoa (Euglena gracilis, Euglena gracilis var.bacillaris, Euglena viridis), etc. β-1,3-glucan can be used, and low molecular oligomers of β-1,3-glucan have a glucose unit of 30 or less, preferably 20 or less. And, the average substitution degree of the functional group in the compound derived from the water-soluble functional group is preferably about 0.1 to 5.0 (per glucose unit sugar), and it is about when considering the dissolution stability with time, compatibility with other components, etc. 0.2 to 3 is particularly suitable for use as an external preparation such as cosmetics.
[0010]
  Used in the present inventionOkra extract refers to various parts of plants(Flowers, flower spikes, fruit spikes, pericarp, fruits, stems, leaves, branches, branches and leaves, trunks, bark, roots, rhizomes, root barks, seeds or whole plants) as they are or after pulverization and extraction. Alternatively, it is extracted as it is or after pulverization with a solvent.
[0011]
  still,Plant extract aboveThe extraction solvent may be selected in consideration of the intended purpose and type of the product to be provided, or the subsequent processing, etc., but usually water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol 1 type or 2 types chosen from various organic solvents, such as polyhydric alcohols or water-containing polyhydric alcohols, such as lower alcohols or hydrous lower alcohols, such as propylene glycol, 1,3-butylene glycol, and glycerin, and acetone It is desirable to use the above mixed liquid. However, when it is not preferable to contain an organic solvent depending on the purpose of use, only water may be used, or ethanol that is easy to remove after extraction may be used alone or in any mixture with water. , Exploited and extracted. Furthermore, it can be used in a state where each solvent extract is combined.
[0012]
  or,Above plantIn addition to hydrolytic extraction by enzymatic decomposition, those obtained by hydrolysis with acid or alkali can also be used.
[0013]
The production method is not particularly limited, but is usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or ion exchange resin is used for adsorption, decolorization, and purification. A solution, paste, gel, or powder may be used. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decoloration may be added as long as the effect is not affected. An activated carbon column or the like may be used, and usual means generally applied depending on the extracted substance may be arbitrarily selected. In addition, an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol, or an arbitrary mixture thereof can be added to the extracted liquid after extraction. Although the obtained extract can be used as it is, it can be concentrated and dried to be used as a paste or powder.
[0014]
  Of the present inventionOkra extract, water-soluble β-1,3-glucan derivative can be contained in hyaluronic acid synthesis promoter,The content is not particularly specified, and varies slightly depending on the type, quality, and expected action of each composition, and is usually 0.0001% by mass or more (hereinafter,%) in terms of solid content in the total amount of the preparation. ), Preferably 0.01 to 50.0%.
[0015]
  In addition, the present inventionHyaluronic acid synthesis promoter dosage formIs optional, and can be used in the form of capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, ointments, sheets and the like.
[0016]
The field of use can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (for example, lotion, milky lotion) , Basic cosmetics such as cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-show lotion, Makeup cosmetics such as shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail preparation, nail enamel, nail enamel Leavening agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, hairs) Treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plaster agents, tape agents, sheet agents, patch agents, aerosol agents, etc.), 5) bath water 6) In addition, anti-smell and deodorant, deodorant, antiperspirant, hygiene products, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, etc. .
[0017]
Furthermore, as foods and beverages, oral compositions (gum, candy, etc.), processed fishery products such as kamaboko and chikuwa, livestock products such as sausages and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat etc. Seasonings such as noodles, sauce, soy sauce, sauce, sugar, honey, powdered candy, syrup, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, red vegetables, sprinkles, or Processed vegetables and fruits such as canned and bottled vegetables, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey drink, soft drink, alcoholic beverages, etc. It can be used for general foods and drinks such as health foods.
[0018]
  In the present invention,Hyaluronic acid synthesis acceleratorIn addition to the above essential components, the components and additives exemplified below can be optionally selected and used in combination as long as the effects of the present invention are not impaired. Is not particularly defined, but usually 0.0001 to 50% is preferable.
[0019]
(1) Various fats and oils
Avocado oil, almond oil, fennel oil, egoma oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard , Squalene, squalane, pristane or hydrogenated products of these oils and fats (hardened oil, etc.).
[0020]
(2) Wax
Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, etc.
[0021]
(3) Mineral oil
Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, etc.
[0022]
(4) Fatty acids
Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.
[0023]
(5) Alcohols
Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol.
[0024]
(6) Polyhydric alcohols
Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol Pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.
[0025]
(7) Esters
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.
[0026]
(8) Metal soap
Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc.
[0027]
(9) Gums, sugars or water-soluble polymer compounds
Gum arabic, benzoin gum, danmar gum, guaiac gum, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or esters thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxy Siethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide, or The cross-linked polymer, carboxyvinyl polymer, polyethyleneimine, etc.
[0028]
(10) Surfactant
Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkylamine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants (natural surfactant, protein Hydrolyzed derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Etc..
[0029]
(11) Various vitamins
Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2 ), Cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin 3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.
[0030]
(12) Various amino acids
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And amino acid derivatives such as sulfate, phosphate, nitrate, citrate, or pyrrolidone carboxylic acid.
[0031]
(13) Various additives derived from plant or animal materials
These are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, washing, hydrolysis, fermentation, purification, pressing, extraction, fractionation, filtration, drying, pulverization) , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization and the like are arbitrarily selected and combined), and may be arbitrarily selected from various materials.
[0032]
The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol 1 type selected from various organic solvents such as lower alcohols such as isobutanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, acetone and ethyl acetate Alternatively, it is desirable to use a mixture of two or more. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.
[0033]
In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relaxation, stress relief by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, imparting gloss, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.
[0034]
In addition, in food and drink, nutritional supplementation, fatigue recovery, tonicity, cell activation (cell aging prevention) and other healthy and cosmetic effects, as well as improved taste, color tone, aroma, gloss, stabilization, thickening, It can be used for antiseptic purposes. In addition to this, various cosmetic and pharmaceutical effects of each of the known raw materials are expected, and by combining these, the intended effect can be promoted or multifunctional. It is also possible to make the product expected to be effective.
[0035]
Specific plants (herbal medicines) as raw materials include, for example, almonds (toen), ai (indigo leaves), aokazura (Keifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Samurai (wooden candy) , Aotenma, acacia, red ginseng, red spruce `` fruit '', red clover, red grapes, red ginseng (logwood), red wrinkles (red buds), red crested or red crested or reddish (root), red crested or reddish (ground yellow), Agi (Aki), Aki larch, Akinire (crusted skin), Aguay Guassou, Aguahe (Omiten coconut palm), Akebi (Kitsu), Asa (Asakojin), Maruba morning glory or morning glory (Chicken), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asenyaku), Athira (Shokuyokanna), Anise, Abiyu, A Biurana, oilseed rape, Abemaki `` fruit '', avocado, ama, achacha (Amacha), Achacharu, Amadokoro (Jade bamboo), Amana (a light-hearted), amaranth (Hyuyu, Hagatetou, Himogeito, Senninkoku, Sugimorigateto, Hosoaogeito, Hasoagoito (Aozzuran, Amaranthus Hypochondriacus), Amiga Sayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Arcana (Arkana), Argarovo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Angelica, Apricot or Honzu (Apricot kernel), Ansokkou (benzoic acid), Yellow support, Igakouzolina (Gallhead), Ikarisou or Yachima Taikoshi (Inyokaku), Rabbits (Kinshin Grass), Japanese knotweed (Tiger root), Yew (first place), Strawberry, Fig ( fig" Fruit, leaves ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seeds, leaves ''), Itohimehagi (distant), locust bean, Inazuna (Taileki), Inubiyu (Honagainubiyu) ), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibuki Sou Sou, Nettle, Iran Iran, Iwa Tobacco (Iwabuchi), Iwahiba or Iwamatsu (Maki), kidney bean, oolong tea, fennel (mud), wheat (Chibusano), Ukiyagara (Sanryo), Uguisukagura `` fruit '', Japanese cypress, turmeric (depressed gold), duckweed (float), usba saishin or keirin saishin or okasai saishin (spicy), usbenia oyster, usbenitachaoi oyster orchid orchid Summer hay), Udo or Shishido (Aki, Aki, Tang Dynasty), Unyadegato (Uncaria, Cat's Claw), Uva , Japanese apricot (seed `` seed, flesh ''), Japanese white beetle, Japanese eelfish (Kusako-kemo), Unshiu mikan (Chen), Unboku, Estragon, Ezoukogi (Tomogoka), Ezo-suzuran, Echinashi (Hosomuramurabareniku), Enishida, Enokitake , Ebisu or Cassia Tora (Keriko), El Campre, Elderberry `` fruit '', Elemi, Elingi or Prerotus eringi, Enju (Safflower, Camellia rice), Pea, Ogi or Kibanaougi (Yellow), Narcoli or Key Carbanarukoyuri (Yellow spirit), Ohisasanoyuki or Sasanoyuki, Auren (Yelen), Ogata Houken, Okarasuuri (Karokon), Oguruma (Civil fragrance), Otsura Rafuji (self-protection), Psyllium (pre-cargo, front-cursed grass), Japanese thistle State leakage, bald eagle), toucan (lion), toucan , Ovana okera or Okera (white birch), Ovanasasuberi (Banaba), Obayayashabushi "fruit", Steller's beetle (cereal sperm), Omia catechu, Hawthorn or Hawthorn (Yamako), Omi palm, Barley (barley), Oka, Okaze Serpentine), Oguruma (turnover), Oguri higotai (Zhengzhou leakage, indigo sashimi), Panax ginseng or Echirea ginseng (Ginseng), Hypericum pertussis or L. pertussis or Hypericum pertussis (broken grass), Odorikosou (continuous), Onamomi Sprouts, Onigurumi, Onikoro or Tokoro or Nagadokoro (Hikai), Oni Yagara (Tempa), Onyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Halibut (Kiribana), Ominaeshi (losing sauce), Oyuko, Netherlands Mustard (watercress), Dutch jellies, Dutch ville, Dutch honey bees, Oh -"Fruits, Seeds, Leaves", Oregano, Orange "Fruits, Peels", Silkworms (Mature Yellow), Cacao "Fruits, Peels, Seeds", Oysters (Powder "Leaf"), Kagi Kazura (Tsukado) , Kakidooshi or Kantori (Lotus herb), Kakiran, Gaku hydrangea, Cassia, Casino oyster (fruit `` fruit ''), Gadju (莪 朮), Kashiwa (Bamboo shoot, Kashiwa leaf), Cascarilla, Cascaraca, Gypsophila, Gypsophila, Crab (Kinshato), Kaniwa, Carnation, Valerian (Valentine Root), Hippopotamus, Birch or Weeping Birch (White Birch), Gerbera, Pumpkin, Kapok'Noki "Seeds", Kahoku Salamander (Garden), Gama (Camellia), Chamomile or Roman Chamomile, chamomile (weed), cam cam (camo duck), carraguwa or yamaguwa (mulberry camellia), color, chrysanthemum salmon, crow cucumber or cinnamon crow (king moth), crow bisha (Half-summer), oats, guarana `` seed '', calahoo (kokubaku), karaya, garyu, karin (garden), garcinia, kawamidori, kawara-cho (commissioned greens, white-billed grass), kawajisha, kawaratake, kawaranadeshiko (stone bamboo) ) Or Ezokawaranadeshiko (buckwheat, buckwheat), Chinese carrot (blue potato), Chinese mugwort (bamboo chin mackerel), kansui (sweet candy), licorice (licorice), kantarasa, candelilla, kanto, canna, kanran, raspberry (ezo strawberry, Dutch Strawberry, Shrimp Strawberry, Narrow White Strawberry, Momiji Strawberry, European Yellow Strawberry), Kiwi `` Fruits, Leaves '', Kikarasuuri (Gurone), Chrysanthemum (Kikyo, Kikyo Root), Chrysanthemum (Chrysanthemum, Zebra Flower, Ginseng), Kikutaniku, Kisage ( (Fruit), scallop (sheep), pheasant (fruit), kizuta, yellow aloe, yellow mint, kina, quinano Ki (Cinchona, Red quince), Quinua (Quinoa), Yellowfin (Yellow), Kimame, Gymnema sylvesta, Kimenkaku, Cabbage, Cabbage `` Immature fruit '', Caraway, Cucumber, Gyory (Nishikawa willow, Tail willow), Kiraja saponaria , Kiraya, Kiranso (Kinza Kosaku), Kumquat “Fruits”, Kinkiju, Ginsekai, Kimbusen, Kinma, Kimihihiki (Sentsukusa), Kinran, Ginlan, Kinryohen, Guapeba Vermelha, Guava “Fruits”, Guayule, Quercus Infectria (Garlic), kukui nuts, kugenumaran, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, ground bark), cedar kazura (tenmon winter), kudu (kudzu), camphor tree, gooseberry `` fruit '', ginseng (yellow flower bud), kudu Titi River, Gardenia (Mountain Lion), Kunugi (Mountain Saw), Kupuas, Kubeba, Mazasa, pine moth (horse whip grass), clara (bitter), cranberry "fruit", chestnut "seed, fruit, astringent skin", curk crifo latifolia "fruit", grapefruit "fruit and leaf", buckthorn, black moth (rescue necessity) , Kamebahikokoshi or kurobanahikikoshi or hikikoshi (prolongation grass), clove (clove, clove), gumba nazuna (sekimei, budgerigar), keigai (butterfly, cocoon), celosia (chicken flower, henko), gekkavidin, bay bay (laurel tree), Kenashi Sartorii rose (earthen soil, mountain return), Gentiana, Gennoshouko (Oldgrass grass), Kemponashi (Kigushi), Kokisekoku, Kushimikan (Koji, Tachibana, Obenimikan, Fuclican, Sagamikouji, Ponkan, Santara (Tachibana bark)), Koshinbara (Moon season flowers), Kousui mint, Kozo `` fruit '', Kocha (Tea), kohone (river bone), koh hong (Tsubakimoto, Karamoto), Koryang, Kouryokyo (Koryo), cilantro `` fruit '', Kouren (Huo Ren), Koganebana (Yellow Gon), cowberry (Etsutachibana), coconut `` Fruit '', Goshuyu (Kurean), Gosho Strawberry (Pepper), Pepper (Pepper), Cosmos, Copaiba Balsam, Coffee `` Seeds, Leaves '', Kobushi or Mokuren (Spicy Pepper), Burdock (Beef Bowl, Beef Bowl), Kobotanru, Sesame (sesame seeds), sesame seeds (genus ginseng), trash (seed), sakanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran "red rice cake, birch", rice oil, cola acminata "seed", cola vera `` Seeds '', Coleus Forskohlii, Colonyella, Koroha `` Fruits '', Colombo, Conzurango, Kombu, Konjac, Comfrey (Chang Zhang grass), Sisal (Sisal Asa), Sa Highland, Sakaneran (Ezosakaneran), Sasima button eel or cinnamon bud or Senacens (weikensen), Sakura (Oshima cherry, Yamazakura, Oyamazakura, Edohashi, Bean cherry, Miyazakura, Yoshino cherry, Takanezakura, Kanzakura, Kozakura, Kokura, Leaf Flowers, fruit, bark (cherry bark) ''), cherries, pomegranate, Sasa, Sasabagin orchid, sasanqua, Sadamodaka (Sawaka), sweet potato, sugar cane, sugar beet, sunflower jujube, saffron (bancho flower, west safflower), sapodilla , Sapotea mariyo, pomelo `` fruit '', savonso, salmon berry `` fruit '', salamander (sasma), salamander (sand sashimi), salvia (sage), ragweed (bamboo rape), sawagurumi (wild walnuts), sankaku cactus The Sangre Grado (croton), Cinnamon carrot, Sancini carrot (Ginseng ginseng), Sanshuyu (Yamamuro), Sansho (Yamamuro), Sandskon (Yamadone), Shia (Kalite), Cyano `` fruit '', Shiitake mushroom (Shiitake) , Zion, Shikakuameme, Dikitarisu, Shikunshi (Ashikiko), Perilla or Aojiso or Chiri-Mendiso or Catameniso (Shiyoha, Shiso-ko), Rosewood, Shinanoki, Shiraho-noki, Shinalen-gyo (ream), Shimeji (Himushiji, Shakashimeji, Hatakeshiji) , Oshiroi shimeji, beech shimeji, honjimeshi, shirotamogitake), shimokren (hot pepper), shimotsuso, potato, peonies (glaze), shajin (shasan), jasmine (matsurika), janohige (bare winter), juroxusage, shukukon Gypsophila, Shukushamitsu (sand seed, shrunk sand), Juzdama, Shuro "fruit", Shun , Zouenashi, Ginger (Ginger), Zozan Hydrangea (Tsuneyama), Shobu (Koji, Sone), Shozu `` Fruit '', Shirakashi `` Seeds '', Silane (Bikkyu), Shirogoricho `` Seeds '', White clover (Clover), White cherry (Chicken bone grass), white squirrels (scented squirrels), white squirrel “flowers”, white sage lupine, shirominanten (southern tenm), cinchona sylbula, ginkgo biloba (mizuka, sika flower, shenzhen), cinnamon, cinnamum cassia (cinnamon) , Watermelon (Saijo), honeysuckle (gold and silver flowers, Shinobu), sorrel (Acid), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', tin-seed coconut (Sugar), sugina (question), purslane (horse teeth) (Skin, horse tooth tender), plum "fruit", sulgaran (oran), red pine "ball cone", caladium Tsutsu, Kizota, Gurmi, Hawthorn, Sunflower, Dandelion, Horse Chestnut (Maroni), Pear `` Fruit '', Prunus serrata, Elderberry (Elder), Prunus (Juniper, Juniper), Millefoil (Milfoil) ), Rose, pearl butterfly, mistletoe, yellow mint or wild mint Nosekoku) (Dendrobium, sarcophagus), Cedron (Boushuboku), Mallow, Hiroha Senega, Senega, Seri, Celery, Senkyu (river cucumber), Senshinren (Punctured ream), Se Dandan, sennin cactus, senna `` fruits, leaves '', senninsou (Otsuka), senburi (medicated), senboku, soka (grass), elephant shoots, prunus, buckwheat `` seed '', some mono-potato, broad bean, daiou (large yellow), Daikon radish, soybean, Daidai (orange peel, fruit), Takasago Gurihigotai (Southeast indigo sashimi), Takasaburo (Cirrus), Takatodai (daikon), Takaharabi (Kashiwaji), dark sweet cherry `` fruit '', hollyhock, Tachi musk (thyme, perilla), tachidokoro (hikai), tachiyanagi, tamarind `` seed '', onion, ramshiba (hot pepper), taranoki `` fruit, leaves, root bark '', tarayou (large leaf winter blue, one leaf tea, bitter tea, bitterness (Tea), Dahlia (Tenji button), Tarwi, Tankimi, Tanshichiwa, Tanjin, Dandelion, Shirobana Dandelion or Mouko Dandelion , Dammar, cherry `` fruit '', chigaya `` fruit, root, bud '', chixetsu carrot (bamboo ginseng), chicory, champa piedra (tulips), tulip, choco no stay, datura (artichoke), datura ), Korean senile (蕪 夷), Korean mugwort (艾艾), Choreimaitake (猪苓), Chorogi, camellia, tsukushikananeran, Tsukutake (mushroom), azalea, camellia, camellia, clover (lacquered licorice), camellia (duck) (Crop grass), vine azuki (red azuki beans), tsurutsuchiakebi, tsurudukudami (what's neck rice), tsuruna (apricot), tsuru carrot (four leaf ginseng), tsurumame, tsuwabuki, daiko, teuchigurumi, duberry `` fruit '', tengusa, tencha (bamboo tea), tendai oyakaku (Glaze), red pepper (winter lion), red pepper, red pepper (banban), Toki (Toyori), Tokinsenka (Marigold), Tosykachichi, Tounabena (river cut), Corn or Corn hair (Minami Kashiwa), Toshikomochi (Sadako), Torindo or Kyousen Lindou (Ryuboku), Toksa (wood bandit) , Dokudami (ten drugs), tokon (root), toshishi or bean pod or pear root, eucommia (Tatsunaka `` bark, leaf, root ''), ash (skin), tomato, tragacanth, triacanthus `` seed '', Turkish Kyo, Torumentilla, Doronoki, Toro-aoi, Tonkame, Niseria berry `` fruit '', Chinese yam or wild yam (Yakuyaku), Nagii Kada (Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Natsume or Vertical oyster (Sword bean), Natsumikan, Jujube Naniwaibara (Kanasakurako), Navena (repeated), Nameko, peanut (peanut), Nanten (nanten) Fruit), Namban Karamushi (Cannabis), Niosumire, Nigaki (Nakiki), Nigamugigi (Anniversary), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabu Nikkei (Cinnamon) or Keishi (Katsura Branch), Nyo-bachidori, Chile ), Elderberry (bone, `` fruit, flower, stem, leaf ''), garlic (large cocoon), nurde (pentose), leek, nemkin or nebu or nembi or nemkinoki or zigokubana (community), noami (large cocoon), noibara ( (Fruit), Nozenkazura (Lingen flower), Nogateto, Yarrow, Nodake (Mae-hu), Novara, Peach, Pineapple `` Fruit '', Hibiscus (Busouge, Furibususouge, Roselle), Hirindou, Gauchiwa, Pau Doce, Hakama Labosi Supplement), Hakkayumatou, Chinese cabbagebird, Hakusen (white ring skin), Hakulberry `` fruit '', Japanese chickweed (breeding), Hazel (coconut), Shiridokoro (roth root), basil, lotus (lotus, lotus meat, lotus root), parsley (holland jellied), hadakamigi, batata, wasp or mushroom (bamboo bamboo), patchouli, mint (thin load, light load leaf), yellow bean, pearl barley ( (Yokuinin), Hanasuge (knowing mother), banana, Hanahaku, Hanabishi (Sitoshi, Shishitsuri), vanilla bins, papaya, scallops, Pahalobo, hub "whole grass, stem, leaf", paprika, Hamakakiran, Hamago or Mitsuba Hamago (Vulgaris), Hamasuge (Katsukiko), Habibishi (Shitsuko), Hamanasu (Maikai Flower), Hamaboufu (Hamaboshi), Hamamelis, Palm, Rose (Rose), Balata, Balata Rubber, Agaric, Agaric ), Haran, Pariurus (Haricus japonica), Parietalia, Harkanran, Balsamina (Tsurure) (Ishi, bitter gourd), harimille (crusted skin, cinnabar white skin, cocoon leaf), Barbasco, Harlindow, HANDAI kai (胖胖 大海), breadfruit, giant eagle (shooting), lizard carrot (participant), pecan nuts, ganbanana (stone carp, (Vulture Shahua), Higurmadaria, Higotai, Hishitai, Pistachio, Beet, Hitsuba (Ishizuchi), Hitsubei Nishida, Daisies (Daisy), Hinata Taikozuchi (cow knee), Japanese cypress, Japanese cypress, Japanese cypress, hiba, castor, Sunflower, Bell Pepper, Himeuzu (Tempo), Himegama (Kaori), Himematsutake (Kawariharatake, Hiromatsutake), Himemuyoran, Pimenta `` Fruit '', Bikushi, Beakkyu, Hiyu `` Fruit '', Chickpea, Hiramame, Bellow Aoy, Hirohao Bald eagle), loquat `` fruits, leaves, stems '', betel nuts (large clothes, coconut), puer tea, sweet pods (south rattan), Japanese cypress, Japanese dandelion (Fuji winter flower, Japanese winter leaf), Fujibakama (Orchid), Japanese bean (Tsuname), Fujimodoki (Chujizakura, Camellia flower), Grape `` Fruits, pericarp, seeds, leaves '', beech, Fuyumushinatsusatake (Chinese insect summer grass), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant coconut, black currant `` fruit '', blackberry, buranyen, plum `` fruit '', fullcellaria, blueberry (Prunus japonica), prunes, floral blanka, blond psyllium, bundo ( Mung beans), hazelnuts, loofah, hetsukaran, safflower (safflower), heneken, belladonna, berries `` fruit '', persair, pervianburg, pereschia grandifolia, red snapper or scenic (scenic sky), boysenberry `` fruit '', scallop or narcissus Or Nendo or Hahagigi ・ Kokia (Golden eel), Hausairan, Blossoms (Akansen, Acute pupa, Radioceae), Pouteria sapota, Pouteria lucuma, Honoki, Spinach, Physalis (Torone), Hononoki (Wat Kobak, Park), Bokeh (Kiso), Hosoba Aragiku (bitter york), Hosobaa Guruma, Hosobanaokera (Amber), Hosoba Kirinso (Keiten 37), Hosobabareniku, Bodaiju (Ogi), Buttons (peony `` flowers, leaves, stems, bark '') , Buttonpi (peony skin), hop, jojoba, borage (borage), Bordeaux, howler berry `` fruit '', hononiku (meat juju, large art), honsekkok (iron skin stone, sparrow mountain stone potato), mizuru tennansho (Tennan star), Maitake (maiko), Maou (mao), maca, macadamia nuts, margaret (mokushungiku), macri (marine grass), mugwa (mulberry bark `` bark, leaf ''), magnolia Sprengeri, Masalan Suva, Masalan Suba de Ceara, Masheira de Boi, Mashua (Tamanousen Hallen, Kyukonkinrenka), Matatabi (Mushroom), Matsukasa, Pine "Leaf, Bark, Root", Matta Oryo, Matsuhodo (茯苓), Matico (Cordon Sillo), Mayoram (Hanahakka), Malvano Jazine (Bitter), Mulberry `` Fruit '', Quince, Malene (Bilaud Muzuka), Mango, Mangosteen, Manzanya (Andesca Mitsule), Manshuugurumi, Mandarin `` `` Fruit '', Mannentake (Reishi), pheasant (fruit `` fruit ''), Mishima Psycho (Shibahu), Mizuoobako or Mizuasagao (Dragongrass), Mizokakushi (half-sided lotus), Misohagi (Chinese vegetable), Michiyanagi or Niwayanagi ( Henshu), Mitsuwashi, Mitsuba, Midori Zapote, Midori Hakka, Mimosa, Myo Moth, miracle fruit `` fruit '', myrrh, mirobaran, wheat straw, mugwort (mushroom), myrtle, mukuroji (life-prolonging skin), munya, purple (purple), purple saxkib (purple pearl), purple corn, purple sasafuji ( Kunming chicken blood wisteria, Megakansa opuntica, Mehajiki (beneficial mother grass), Mebougi, Japanese evening primrose (Evening primrose), Melaroica, Melissa, Melilot, Melon `` fruit '', Moukomugi, Mosouchiku, Mokkirin, Moje (Pepper), Mochinoki, Mochinoki Incense), Japanese maple peach, Peach (peach `` leaves, seeds, flowers, fruit ''), coconut palm, Morello cherry `` fruit '', Morohaya (burlap), Yakawamuraimo, Yakuchi (Michichi), cornflower (cornflower), Cornflower mint, yacon, yaba santa, yashabushi Fruit or persimmon `` fruit, pericarp, fruit ear '', willow willow, starfish (octagonal gold plate), mistletoe (willow infestation), willow (kawayanagi, tachiyanagi, weeping willow), red willow, cat willow, incolyanagi, kinuyanagi, miryana, unrya Palms, willows, giant willows, red willows, fox willows, dronoks), willow tree `` leaves, stems '', jabgarashi, yabukouji (purple gold beef), yab tobacco (crane crane, Tenmeisei), pokeweed (commercial land), yamahanoki ), Japanese yam, Japanese sagebrush, Eucalyptus, Yukinoshita (tiger ear grass), Yucca or flavifolia, Yuzu `` fruit '', Lily, Yorusa, mugwort (birch leaves), Ligan (Raimaru), Lime `` fruit '', rye, Lacanca "fruit", raspberry "leaves, fruit", latania (chlamelia), latte Leopard or shallot (palm white), lavender, longan (long-eyed meat), agave (Aon agave, fuchlin agave), ryocha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, lubas or suabisimus (cool), Ruritama Thistle (Vulgaria chintai, Xinjiang indigo sashimi), Reishi (toothpick, toothpick core), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (ream), Astragalus, waxy, wax palm, locon (Yoshi, Sone), Loganberry "fruit", rosemary (Mannenrou), rosehip (Nobara), wasabi, cotton wisteria (Mong Monflower), Waremokkou (earthen) Etc.
[0036]
As seaweeds, seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), Anaaosa (Aosa)] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Neocitus Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etuki Umi Uchiwa], seaweed [Red Algae: Hijirimen, Maca (Tengusa), Hiluxa, Syria, Oaxa Caterpillar, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper ginkgo rhinoceros, Tsunomata, Totsuka (Yahazutsu notamata), Ezotsunotamata, Togetu no Takita , Yaleus banori, Kagius banori, Susius banori, Haius banori, Akamo mizunori] and the like.
[0037]
In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kuwanomimo: Kuwanomimo, Volbox: Ohigegawa, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Hitogususa genus: Humanegusa, Hirohatohigususa, Umushihimoe, Sakikimoe Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).
[0038]
Cyanobacteria (Suizenjinori genus: Suizenjinori, Aoko genus, Nenjumo genus: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.).
[0039]
Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozu, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: lobster, genus genus: Yokojimari, Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Ukimo: Ouokimo, Burukimo: Burukimo, Kayamonori: Kayamonori, etc.).
[0040]
Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Proboscis: Giant plover, Hytengus, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashkarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobasho: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haezaki Sawflower, Kawamoku : Kawamoke, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okichizu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).
[0041]
Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotamnus, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.
[0042]
In addition, the materials derived from animal materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig brain tissue Extracts, cattle / pigs / fish collagen hydrolyzate (acid, alkali, enzyme etc.) degradation products, water-soluble collagen or collagen derivatives such as acylated collagen, cattle / pigs / fish elastin or elastin hydrolyzate (acid, Alkaline, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or cow blood cell protein degradation product (globin peptide), cow or pig hemoglobin Degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or derivatives thereof, skim milk powder and its degradation products or it Derivatives, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.
[0043]
In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, etc. derived from a gene recombinant or a cell fusion can be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.
[0044]
(14) Marine components
Seawater such as deep sea water, for example, sea salt, dried seawater, dead sea or Atlantic or Pacific sea water (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango), for example Sea mud or mud from various locations such as Italy, Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, black meteorite, etc.
[0045]
(15) Microbial culture metabolites
Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice cake, birch ) Fermented extract, Euglena extract or decomposition product thereof or water-soluble derivative thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, lactic acid bacteria fermentation product of legumes, lactic acid bacteria fermentation product of coconut genus plant, etc.
[0046]
(16) α-hydroxy acids
Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.
[0047]
(17) Inorganic pigment
Silica, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.
[0048]
(18) UV absorption / blocking agent
Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfone Acid sodium, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.) , Methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, paramethoxycinnamate Acid sodium, potassium paramethoxycinnamate, glyceryl diparamethoxycinnamate mono-2-ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.) , Anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, Furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone Esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESCA rolls, zinc oxide, talc, kaolin.
[0049]
(19) Whitening agent
Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives Nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein , Berberine, placenta extract, ellagic acid, lucinol etc.
[0050]
(20) Tyrosinase activity inhibitor
Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or a derivative thereof , Glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, touki, firewood, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhod, Pearl barley, nettle, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankei, hamamelis, carraguwa or yamagwa, life-grass, bellflower, toshishi, sequel, shooting dry, mao, senkyu, dokatsu, psycho, Ufuu, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
[0051]
(21) Melanin pigment reduction / degradation substances
Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivatives (hydroquinone benzyl ether).
[0052]
(22) Turnover promotion / cell activator
Hydroquinone, Lactic acid bacteria extract, Placenta extract, Ganoderma extract, Vitamin A, Vitamin E, Allantoin, Spleen extract, Thymus extract, Yeast extract, Fermented milk extract, Plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock, Shikon, Carrot, (Hamelis, hops, Yokuinin, Odori-sou, assembly, Toki, Toki-Senka, Achacha, Hypericum, Cucumber, Pepper, Mannenro, Parsley).
[0053]
(23) Astringent
Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds), etc.
[0054]
(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.
[0055]
(25) Antioxidants
Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamorin, gossypol, propolis, etc.
[0056]
(26) Lipid peroxide production inhibitor
β-carotene, plant extract (sesame culture cell, amacha, hypericum, clams, clove, melissa, enamel, birch, salvia, mannenrou, nanzenji, ages, ginkgo, green tea).
[0057]
(27) Anti-inflammatory agent
Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its Salt, licorice extract, sicon extract, age extract, propolis, etc.
[0058]
(28) Antibacterial / disinfectant / disinfectant
Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salicy powder, iodine compound, iodoform, sorbin Acid or salt thereof, propionic acid or salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m -Xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol Isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl) Phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride) , Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, jarmal, feeling Photoelement 101, Photosensitive element 201, Photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, zinc oxide, hinokitiol, kudin, propolis, and the like.
[0059]
(29) Moisturizer
Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative Pyrrolidonecarboxylic acid or a salt thereof, sodium lactate, urea, sorbitol, amino acid or derivative thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, Tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates and phosphates Nitrates, citrates, or pyrrolidone carboxylic acids), fats and oils “Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, Beef tallow fatty acid, quince seed oil, cucumber nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil, Turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, palm oil, eucalyptus oil, beef tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (cured oil) , Waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, Lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), natto bacteria metabolites, natto extract, silk fiber extract, plant extract (Akamatsu) Sap, aloe, kudzu, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or white birch sap, assembly, mulberry white bark, maple leaf, loofah, peony skin, persimmon).
[0060]
(30) Elastase activity inhibitor
Fluorophosphate diisopropyl, plant extracts (Ogon, Hypericum, Clara, Mulberry leaves, Keihi, Gennosho, Comfrey, Salvia, Elderberry, Bodaige, Buttonpi), seaweed extract, etc.
[0061]
(31) Hair preparation
Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, ginger tincture, red pepper tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid and the like.
[0062]
(32) Antiandrogen
Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, etc.
[0063]
(33) Peripheral blood flow promoter
Vitamin E or its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.
[0064]
(34) Stimulant
Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate, etc.
[0065]
(35) Metabolic active agent
Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.
[0066]
(36) Antiseborrheic agent
Pyridoxine or its derivatives, sulfur, vitamin B6 and the like.
[0067]
(37) Keratolytic agent
Resorcin, salicylic acid, lactic acid, urea, etc.
[0068]
(38) Oxidizing agent
Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate Sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.
[0069]
(39) Hair remover
Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.
[0070]
(40) Hair swelling agent
Ethanolamine, urea, guanidine, etc.
[0071]
(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, paraphenylenediamine, paramethylamino Phenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N -Phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diamino sulfate Diphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, parasulfate sulfate Methylaminophenol, metaaminosulfate Diol, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfone Sodium acid, hematein, etc.
[0072]
(42) Fragrance
Natural animal fragrances such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, Tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, troubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, pel Plant flavors such as balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannenrou) essential oil, Japanese mint mint essential oil, etc. Synthetic fragrance etc.
[0073]
(43) Dyes / colorants
Red cabbage dye, red rice dye, red dye, anato dye, scum dye, turmeric dye, enju dye, krill dye, amber dye, caramel, gold, silver, gardenia dye, corn dye, onion dye, tamarind dye, spirulina dye, Buckwheat whole pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.
[0074]
(44) Sweetener
Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract, etc.
[0075]
(45) Nutrition enhancer
Shell-calcined calcium, cyanocolabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron, etc.
[0076]
(46) Dairy products
Milk, cheese, fresh cream, butter, margarine, powdered milk, whey, condensed milk, etc.
[0077]
(44) Other
Hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and vegetable polysaccharides and their degradation products , Animal / plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents / anti-inflammatory agents / anti-allergic agents, wound treatment agents, foam enhancers, thickeners, enzymes, purified water (electronic water, small clusters) ), Oral preparations, deodorants / deodorants, bitterings, seasonings, etc., and the combined use with these is expected to provide additive or synergistic improvements to the effects of the present invention or other cosmetic effects. it can.
[0078]
  In the present invention,To hyaluronic acid synthesis acceleratorThe addition method may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.
[0079]
【Example】
Hereinafter, production examples, test examples, and formulation examples will be described, but the present invention is not limited thereto.
[0080]
(Production Example 1)
Purified water (1 kg) is added to each plant (100 g) of aloe and okra and heated to 80 ° C or higher for extraction. Subsequently, the extract (about 1 kg) obtained by suction filtration is concentrated. Ethanol is added to the concentrated liquid (about 300 g) to cause alcohol precipitation, and the precipitate is collected and dried (about 10 g). Dissolve the dried product in purified water to make a solution (about 50 g). If necessary, ethanol, 1,3-butylene glycol, preservatives and the like may be added.
[0081]
(Production Example 2)
Aloe and okra plants (100 g) are immersed in 10% ethanol solution, 30% 1,3-butylene glycol solution, 30% propylene glycol solution, or purified water (about 30 ° C), and 3-7 at room temperature After extraction day and night, filtration is performed to obtain about 1.0 kg of an extract.
[0082]
(Production Example 3)
After pulverizing yeast or Euglena plants (100 g), they are treated with a surfactant and repeatedly purified by washing. The product is collected and dried to obtain β-1,3-glucan (about 30 g). This is dissolved under alkaline conditions, and is made soluble by introducing a carboxymethyl group with sodium monochloroacetate (about 1 kg).
[0083]
(Production Example 4)
Baker's yeast (500 g) is dispersed in ten times the amount of purified water, self-digested at about 37 ° C. for 48 hours, this solution is filtered, and a small amount of absolute ethanol is added to the obtained filtrate to obtain about 4 kg of yeast extract. .
[0084]
(Test 1) Hyaluronic acid production promoting action test
"Test method and evaluation method"
5 x 10 in each well of 24-hole plate (Corning 3526)^Four1 mL of (cell / mL) normal human newborn foreskin dermal fibroblasts NHDF (NF) was seeded. Using DMEM medium (Kurabo) containing 5% FCS (fetal calf serum), 37 ° C, 5% CO₂After culturing for 3 days, the medium was replaced with a DMEM medium containing 0.5% FCS and the sample was added. Furthermore, the amount of hyaluronic acid (HA) was measured by ELISA using the culture supernatant after 24 hours of culture as a sample. At the same time, the number of cells was counted and evaluated as the amount of hyaluronic acid per cell. Purified water was used as a blank and N-acetylglucosamine was used as a positive control, and added to a test container to a final concentration of 0.1 mM. Other naturally derived ingredients were added to the test container to a final concentration of 10 ppm. The results are shown in FIG.
"sample"
For the samples of this test, various naturally-derived components obtained in Production Example 1, Production Example 3 and Production Example 4 of the present invention were adjusted to a solid content of 0.1% and subjected to the test.
[0085]
(Test results)
  As shown in FIG.Okra extract, water-soluble β-1,3-glucan derivativeThus, it was confirmed that it has the effect of significantly promoting the synthesis of hyaluronic acid.
[0090]
(Test 3) Safety test
(1) Skin primary irritation test
Hartley guinea pigs (female, 3 per group, body weight 300-350 g) prepared by preparing various natural ingredients obtained in Production Examples 1 to 4 so that the solid content concentration is about 2.0% and shaving the back. 2x2cm of skin²0.03 mL per square was applied. Judgment was performed 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indicators. As a result, in all animals, no erythema and edema were observed, and it was judged negative.
[0091]
(Test 4) Safety test
(2) Cumulative skin irritation test
The various naturally-derived components obtained in Production Examples 1 to 4 were prepared so that the solid content concentration was about 2.0%, and this was shaved on the flank (2 × 4 cm²) Hartley guinea pigs (female, 3 mice per group, body weight around 320 g) were applied once a day, 5 times a week, 0.5 mL / per animal. Application was for 2 weeks, and shaving was performed on the last application day of each week. Judgment was made on the day of each application and the day after the last application by the scoring method of primary irritation using erythema and edema as indices. As a result, in all animals, no erythema and edema were observed for 2 weeks after application, and it was judged negative.
[0092]
(Test 5) Safety test
(3) Single dose toxicity study
Various naturally-derived components obtained in Production Examples 1 to 4 were adjusted with purified water to a concentration of 12.5%, and 16 mL / kg amount per animal was fasted for 16 hours before the test (male and Females, 5 animals per group, 5 weeks of age) were orally administered with a sonde, and the onset, degree, etc. of toxic symptoms were observed over time. As a result, no abnormalities were observed in all mice for 14 days, and no abnormalities were found in the anatomical results. Therefore, LD₅₀Was 2,000 mg / kg or more, and judged to be a safe substance.
[0093]
(Formulation example) Hyaluronic acid synthesis accelerator, cosmetic composition and production of food and drink
According to said evaluation result, the example of the formulation is shown below, but each formulation example may be what was manufactured by the conventional method in manufacture of each product, and showed only the compounding quantity. The present invention is not limited to these.
[0094]

[0095]

[0096]

[0097]

[0098]

[0099]

[0100]

[0101]

[0102]

[0103]

[0104]

[0105]

[0106]

[0107]

[0108]

[0109]

[0110]

[0111]

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[0115]

[0116]

[0117]

[0118]

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[0120]

[0121]

[0122]
(Prescription Example 29) Coating protective agent
Gauze or liniment cloth is impregnated with an okra hot water extract and a prescription solution mixed with appropriate amounts of water-soluble β-1,3-glucan derivatives, antibiotics, anti-inflammatory agents, etc. and attached to the wound. Alternatively, the okra hot water extract and the water-soluble β-1,3-glucan derivative may be directly sprayed locally and covered with gauze or the like.
[0123]

[0124]

[0125]

[0126]

[0127]

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[0133]
(Test 6) Use effect test
  Cosmetic composition of the above formulation exampleThe effect when actually using was examined. The use test was conducted by applying 10 healthy adult females 25 to 50 years old as panelists and applying the appropriate amount of the emulsion of Formulation Example 1 to the face for 3 months after washing their face every morning and night. . In contrast,A product obtained by removing various naturally-derived components from the emulsion.Was formulated in a similar manner. The evaluation method is based on the following criteria, and the results are as shown in Table 2. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.
[0134]
"Improve skin tension and gloss"
Effective: Increased skin tension and gloss.
Slightly effective: Slightly increased skin tension and gloss.
Invalid: No change before use.
[0135]

[0136]
(Test results)
  As shown in Table 2,An emulsion containing various naturally derived ingredientsIt was confirmed that the skin tension and gloss were significantly improved and that the skin wrinkles were reduced.
[0137]
(Test 7) Use effect test
  Food of the above prescription exampleThe effect when actually using was examined. The use test was conducted by 10 healthy adult females 25 to 50 years old as panelists, and each day, twice a day in the morning and evening, and one bread of prescription example 35 (about 50 g at a time) was eaten and consumed for one month. It was. In contrast,Bread without various natural ingredientsWas formulated in a similar manner. The evaluation method is based on the following criteria, and the results are as shown in Table 3. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.
[0138]
"Improve skin tension and gloss"
Effective: Increased skin tension and gloss.
Slightly effective: Slightly increased skin tension and gloss.
Invalid: No change before use.
[0139]

[0140]
(Test results)
  As shown in Table 3,Bread with various natural ingredientsWas able to significantly give skin firmness and gloss, and also confirmed that the skin tarmi was reduced.
[0141]
【The invention's effect】
  Of the present inventionThe okra extract and water-soluble β-1,3-glucan derivative were confirmed to be highly safe and significantly promote hyaluronic acid synthesis.Furthermore, the cosmetic composition and food / beverage products which mix | blended these have skin aging prevention effects, such as provision of tension | tensile_strength and gloss, or improvement of wrinkles and a sagging with respect to skin.
[Brief description of the drawings]
FIG. 1 is a graph showing hyaluronic acid synthesis promotion rates of the aloe extract, okra extract, water-soluble β-1,3-glucan derivative and yeast extract of the present invention.

Claims (1)

A hyaluronic acid synthesis promoter containing, as an active ingredient, one or more selected from okra extract and water-soluble carboxymethylated β-1,3-glucan .

Images