JP2002363057A - Melanogenesis inhibitor or cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new and safe melanogenesis inhibitor or a cosmetic composition having melanogenesis inhibiting action, improving skin spot and freckle and having improving effect to make skin color white and further capable of imparting gloss and tenseness to skin and preventing aging of skin. SOLUTION: This invention provides the melanogenesis inhibitor or the cosmetic composition comprising extracts of one or more kinds of plants selected from Polygala tenuifolia Willd., Aristolochia debilis Sieb.et Zucc., Pinellia ternata Breitenbach, Vaccinium vitis-idaea L. and Cyperus rotundus L.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an application to a melanin production inhibitor or a cosmetic composition containing at least one plant extract selected from Aedes aegypti, Echinacea purpurea, Raspberry prunus, Betula edulis, and Lepidoptera.

[0002]

2. Description of the Related Art Factors determining human skin color include the amount of melanin in the epidermis, blood flow in capillaries, pigments derived from food (carotene), and the thickness of the stratum corneum. One of the most important factors is melanin pigment. The so-called liver spots (spots), sparrow egg spots (buckwheat spots), and pigmentation of the skin after sunburn are those in which the production of melanin pigments has been significantly enhanced by the activation of pigment cells present in the skin. And for women, it is one of the major worries of the skin.

[0003] The melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the hair root, and the outer root sheath. In the process of melanin production, tyrosinase is activated by tyrosine in pigment cells (melanocytes) to oxidize tyrosine,
It is converted to dopa and dopaquinone, further autoxidized, polymerized via dopachrome and 5,6-dihydroxyindole, and finally turned into a melanin pigment. The produced melanin is
Pigment cells (melanocytes) are secreted by the dendrites of basal cells into basal cells.The basal cells divide, become spiny cells, rise and reach the stratum corneum, and then fall off as the stratum corneum detaches. .

Accordingly, in order to prevent or improve skin spots, spots, and freckles on the skin, the production of melanin is inhibited. Alternatively, it is conceivable to make already generated melanin lighter. Therefore, various whitening components have been conventionally proposed based on these ideas. For example, kojic acid or a derivative thereof, ascorbic acid or a derivative thereof, tocopherol or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract or plant extract (Arnica, Altea , Aloe, Japanese gourd, Japanese ginger, chamomile, licorice, gardenia, genoshoko, sicon, ginger, birch, senkyu,
Gennoshoko, Psycho, Sasanqua, Toki, Calendula, Elderberry, Safflower, Garlic, Adlay, Reishi, Logwood) and the like are known.

[0005]

However, the above-mentioned whitening ingredients have poor stability and solubility in the formulation system, cause unpleasant odor and coloring due to sedimentation and decomposition, and have insufficient effects at the biological level. There was also a problem in terms of safety such as skin irritation, which was not satisfactory.

[0006]

In view of these circumstances, the present inventors have developed a useful plant having an inhibitory action on melanin production as a theme of development, and as a result, have been selected from Itohimehagi, Umanosuzukusa, Karasubisakaku, lingonberry and Hamazuge1. It was confirmed that more than one plant extract significantly suppressed the production of melanin pigment and had a whitening effect. And to improve skin spots, freckles, and whiten skin color.
Further, the present invention has been completed by providing a highly safe melanin production inhibitor or a cosmetic composition capable of giving gloss and tension to the skin.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The term "Itohimehagi" (also known as "Itohimehagi", "Onji", "Enshi") used in the present invention refers to a family of the family Himehagi.
(Polygalaceae), a plant of the genus Polygala (Polygala): flowers, crimson fruit, (Polygala tenuifolia Willd.)
Use peel, fruit, leaves, branches, rhizomes, root bark, roots or whole plants, but also other species of the same species, Himehagi (P. japonica Houtt.),
Kakinohagusa (P.reinii Fr.et Sav.), Senega (P.senega
L.) can also be used.

[0008] "Amanospercaceae (also known as horse suzukusa, mika, mokko)" refers to the family Aristrochia (Aristrochia)
ceae), a plant of the genus Aristolochia (Aristolochia): Uses the peel or fruit, berries, flowers, rhizomes, and roots of the crab (Aristolochia debilis Sieb.et Zucc.).
YC Wu ex Chow et Hwang = (A.westlandia Hemsl.), A. heterophylla Hemsl.
l.), A. kaempferi Willd. and A. manchuriensis Komarov can also be used.

"Krasubisaku (aka: midsummer, hange)"
Is a plant of the family Araceae (Araceae) and the genus Pinellia (Pinellia): "Pinellia ternata Breitenbach =
(P.ternata (Thunb.) Breit.) "Tuber or rhizome, corm,
Roots and stems are used, but other species of the same species (P. tri
partita Sohott) can also be used.

"Cowberry (also known as moss peach)" refers to ericaceae
(Ericaceae), a plant of the genus Vaccinium: Cowberry (V
accinium vitis-idaea L.) flowers, spikes, spikes, pericarp,
Fruit, stem, leaf, branch, branch and leaf, stem, bark, rhizome, root bark, root,
Seeds or whole plants are used, but in addition, rabbit eye blueberries (V. ashei Reade.), Highbush blueberries (V. australe Small.), Bilberries (V. myrtil)
lus L.), Kuromenoki (V.uliginosum L.), Cranberry (V. macrocarpon Ait.), Lowbush Blueberry
(V.angustifolium Ait.) Can also be used.

[0011] "Hamasuge: (alias: Hamagasuga, Kabushiko, Kobushi)" is a plant belonging to the family Cyperaceae, Cyperus, and the plant of the genus Cyperus rotundus.
L.) tubers or rhizomes, corms, roots, stems and whole plants are used.

[0012] The extracts of Itohimehagi, Echinacea japonicus, Raspberry japonicus, lingonberry and chamomile, which are used in the present invention, refer to various parts of each plant (flowers, cotyledons, fruits, peels, fruits, ears, stems, corms, leaves, Branches, foliage, trunk, bark,
Rhizome, root bark, root, tuber, seed, whole plant, etc. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the content of the organic solvent is not preferable due to the purpose of use, water alone may be used, or ethanol which can be easily removed after extraction may be used alone or in any mixed solution with water. It may be an extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

In addition to the above-mentioned various plants, those obtained by hydrolysis with an acid or alkali, in addition to hydrolysis and extraction by enzymatic decomposition, can also be used.

Although the production method is not particularly limited, it is usually sufficient to be within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected. Further, an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, or an arbitrary mixture thereof can be added to the extract after extraction. The obtained extract can be used as it is, but it can also be used as a paste or powder after concentration and drying.

According to the present invention, it is known that Itohimehagi and Umanosukuda
A variety of plant extracts of crows, bilberries, and locusts can be contained in a melanin production inhibitor and a cosmetic composition, and the content thereof is not particularly defined.The melanin production inhibitor, the type and quality of the cosmetic composition Slightly different depending on the expected degree of action, and is usually 0.0001% by weight or more (hereinafter, expressed as%) in terms of solid content in the total amount of the preparation,
Preferably, 0.01 to 50.0% is good. In the case of a bath agent, the formulation may be considered so as to be poured into 200 to 300 L of bath water so as to have the same concentration.

The melanin production inhibitor and the cosmetic composition of the present invention may have any dosage form and form, such as capsules, powders, granules, solids, liquids, gels, air bubbles, emulsions, creams, ointments,
It can be used in the form of a sheet or the like.

The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g., cosmetics) in suitable forms for use in liquids, gels, bubbles, emulsions, sheets, mist, sprays, etc. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, and packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, depilatory agents, shaving treatments, after-shave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, nail polish, nail enamel, nail enamel remover, cataplasm,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, hair treatments, pre-treatments) Agents, permanent solutions, hair dyes, hair styling agents, hair tonics, hair growth / hair restoration, cataplasms, plasters, tapes, sheets, patches, aerosols, etc.), 5) 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpastes, mouth fresheners, gargles and the like.

The melanin production inhibitor and the cosmetic composition of the present invention may optionally contain, in addition to the above-mentioned essential components, any of the following components and additives within a range that does not impair the effects of the present invention. The content in the preparation is not particularly limited, but is usually 0.0001 to 50%
Is preferred.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, squalene,
Squalane, pristane, hydrogenated products of these oils and fats (hardened oils, etc.) and the like.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Natural fatty acids such as docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, and lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, and 2-ethylhexane Synthetic fatty acids such as acids and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol;
Synthetic alcohols such as hexyldecanol, isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) to which an alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its crosslinked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxerol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Or amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, etc. Select from alcohols, lower alcohols such as butanol and isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or water-containing polyhydric alcohols, acetone and various organic solvents such as ethyl acetate. It is desirable to use one or a mixture of two or more of these. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water, Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
Antiseptic and buffering effects can also be expected.

As a specific plant (crude) as a raw material,
For example, almonds (herring peach), eyes (blue leaves), blue moss
(Seifu Fuji), Aoki (Aoki), Aogiri or Kenasia Ogiri
(Otogi), Aotsu-la-fuji (Kibo), Aotenma, Acacia, Akasho (Akasho), Akasuguri (fruit), Red clover, Red grape, Akaminoki (Logwood), Akamegawiwa (Red bud), Akaminokane or Akane Akane or Akane (Akane) Grass root), red pheasant or pheasant (land yellow),
Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Wolverine palm), Akebi
(Kidori), Asa (Jin Asako), Malva Asagao or Asagao
(Toshiko), hydrangea (hydrangea), ashitaba (morning leaves), azuki (red azuki bean), asunaro, acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abiu, abiulana, rape and abemaki `` fruit '' ,Avocado,
Ama, Amacha (Amacha), Amachaworu, Amadokoro (Jade bamboo), Amana (Kojingi), Amaranthus (Hyuyu, Hagaito, Himogeito, Senninkok, Sugimorigeito,
Hosoagaitou, Aoagetoi, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Urizusensen), Arcana (Alcanna), Algarrobo (Cave), Altea, Arnica, Alpinia or Katsumadai
(Sorghum), aloe (lux), aloe vera, angelica, apricot or hon apricot (almond jelly), ansokko (benzoic acid), yellow sapote, scutellaria (biliary head), epimedium or primrose (inyokaku), rush
(Wicked grass), Knotweed (Tiger root), Yew (1st), Strawberry,
Figs (fructose `` fruits and leaves ''), Ichihatsu (first), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginko `` seed and leaves ''), carob, beetle, dog breeding (Telelexi), inubeyu (scallop) , Rice `` seed, seed coat '', inode `` seed '', Ibuki mud wort, nettle, ylang-ylang, iwa tobacco (Iwagashi chi), iwahiba or iwamatsu (makikashi), oolong tea, fennel (fenka), wheat (chibusanoki), ukiyagara (three) Ridge), Uguisukagura "fruit", Himeuikyo, turmeric (Utsukin), duckweed
(Buoying), Usubasaishin or Keirinsaishin or Aushousaishin (spicy), Usvenia oyster, Usvenitahiaoi, Uchouran, Utsubogusa (summer hay), Udo or Shishiudo (Qang activity, independence, Tang dynasty), Unya de Gato (Unkariya, Cats) Crow), Uba tea, Ume (Umebashi `` seed, flesh ''), Vulgaris, Uwaurushi (Kusaco peach), Unshuri mandarin (Chen skin), Unboku, Estragon, Ezukokogi (Ezo Goka), Ezo suzuran, Echinashi (Hosobamurasakisakibarengiku), Enishida Enokitake (Enoki mushroom), Ebisugusa or Cassia tora (Keyoshiko), Elcampre, Elderberry `` fruit '', Elemi, Elingi or Prelotus elinge, Endu (Gossip, Sophora rice), Ougi or Kibanaohagi (Kokigi), Narco Lily or Kagikurumabanaruko lily (Yellow), Ohisasa Yuki or Sasanoyuki, Coptis (Coptis), Oogatahouken, giant Karasuuri (Karokon), Ooguruma (civil engineering incense), giant Tsudzurafuji
(Self-defense), plantain (car front child, car front grass), psyllium thistle
(Keju Leak, Hakuto Okina), Toucan (Haruko), Toucan cactus, Oobanokera or Okera (white juku), Oobansarusubari (Banaba), Oobayashibashi "fruit", Ooishigusa (cereal grass), Oumiacatetsu, Omihacateshi or Omihasabi Hawthorn (Yamako), Barley (barley), Oka, Okazeri (Snake bed), Okra `` fruit '', Oguruma (turnover), Oculli higotai (Yushu sashimi, indigo head), Panax ginseng or Ginseng (carrot), St. John's wort or St. John's wort or St. John's wort (St. edulis), St. John's wort (interrupted), Onomimomi (Blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara
(Tianma), Oni lily or Sasa lily or Hakata lily (Yuri),
Onoelan, Ononis, Halibut, Ominaeshi
(Losing sauce), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch biyu, Dutch honeysuckle, olive "fruit, seed, leaf", oregano, orange "fruit, peel",
Kaikei (ripe yellow), cacao `` fruits, peels, seeds '', oysters (persimmon `` leaves ''), kagikazura (fishing hooks), oysters or kantosou (lotus grass), kakiran, gaku hydrangea, cassia, casinoki ( Mulberry fruit (fruit)), gajutsu (shajujutsu), kasiwa (shaki, kayoha), kasukaira, kascara sagrada, gypsophila, kasensou, kanikusa (kinsato), kaniwa, carnation, kanokosou (yoshikone), hippo,
Birch or weeping birch (white birch), gerbera, pumpkin, kapok tree, `` seed, '' kahoku sansho (shopper),
Gama (bamboo), chamomile or roman chamomile, chamomile
(Weeds), camucum (duckling), color, karaksakeman, crow squirrel or cinnamon cucurbite (gold melon), oats wheat, guarana `` seed '', karahoo (thick), karaya, garyu, karin (mochi), garcinia, kawamidori, kawarashiko ( (Koryo greens, vermilion grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawarangin (blue wheat), Kawamogimogi (ingotoko), Kansui (sweet), licorice (licorice) ), Canthalaasa, candelilla, cantola, canna, canlan, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, pear strawberry, maple strawberry, european strawberry),
Kiwi "fruit, leaf", kikarasuuri (urorone), kikyo
(Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Shima kaniku, Datura), Chrysanthemum, Catalpa (Azusa), Rigix
(Yotei root), Pheasant (Kikomi), Kisuta, Kidachi aloe, Kidachi minka, Kina, Kinoki (Shincona, Akaki linoki), Quinoa (Kinoa), Kihada (Huangkashii), Gymnema sylvesta, Kimmenkaku, Cabbage, Cabbage `` Immature fruit '',
Caraway, cucumber, gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja saponaria, Kiraya, Kiranso (gold pea grass), kumquat "fruit", ginseki, kimbusen,
Betel, kinmizuki (golden ranch), golden orchid, ginran,
Kinryohen, guapeba vermelha, guava "fruit", guayule, quelux infectria
(Garlic), Kukui Nuts, Kugenumaran, Kuko
Gugiko, gugi leaf, ground bone bark)
Kudzu (Kakkon), camphor tree, gooseberry `` fruit '', ginseng (yellow flower), cutiti river, gardenia (garden garden), kunugi (bokuso), cupuas, kubeba, kumazasa,
Black pine (horse whip grass), Clara (bitter butter), chestnut `` seed, fruit, astringent skin '', curculigo latifolia `` fruit '', grapefruit `` fruit / leaf '', buckthorn, black crocodile (rescue rescue), turtle bamboo stork or kurobana cypress or cypress (Extended life grass), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), kaigai (infested, infested ears), celosia (cotyledon, rooster), gekkavidin, bayberry (laurel), kenashisarutoribara (tobukuryo, mountain comeback) ), Gentiana, Gennoshoko (Older's grass), Kemponashi (Kigushi), Koukisekikoku, Kishumikan (Koji, Tachibana, Obenimikan, Fukuromikan, Sagamikouji, Ponkan, Santara (Tachibana skin)), Koshinbara (Monthly flower) , Kozo "fruit", kocha (tea), kohone (river bone), kohon (Straw book, Kara straw book), Koryang, Koryokyo (Kora Kyo), Koendro `` fruit '', Kouren (Kohren), Koganebana (yellow gon), Coco palm `` Fruit '', Goshyu (goshuyu), Goshoichigo (covered bonsai), pepper (Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame hamagusa (gensin), goshishi (gomiko), scallop Or Binankazura or Matsubusa, wheat (wheat), rice or rice bran `` red bran, white bran '', rice oil, cola acuminata `` seed '', cola vera `` seed '', colony llah, fenugreek `` fruit '', colombo, conzulango, kelp, Konjac, Comfrey (Finari grass), Sisal (Sisal Asa), Saihylan, Sakanelan (Ezosakanelan), Sakisima button or Sinabota Perilla or chinsensou (weird spirits), cherry (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura `` Leaf, flower, fruit, bark (cherry bark)) , Cherry, pomegranate, sasa, sasabagin orchid, sasanqua, sagemodaka (sawaka), sweet potato, sugar cane, sugar beet, satsume jujube (acid jujube), saffron (red safflower, western safflower), sapodilla, sapote mariyo, pomelo, fruit Berries "fruit", Sarasinuma (Masahima), Saranshito
(Sand indigo sashimi), Salvia (sage), Sawagikyo (Yamakona), Sawagumi (Yamawomo), Sankaku cactus, Sangre degrad (Croton), Sansouyousou, Sanshin ginseng (37 ginseng), Sanshuyu (Sanshuyu) ), Sansho
(Sansho), Sandscon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shiitake), Shion (Shion), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimendiso or Catamenziso (Shiso leaf, (Shizo), rosewood, linden, Chinese pine, Chinese forsythia, shimeji
(Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishimeji, Bunashimeji, Honjimeshi, Shirotamogitake),
Shimokure (Spirit), Spiraea, Potato, Peony (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Motomon winter), Scutellaria paniculata, Skushamitsu (sand sand, shrinking sand), Juzudama, Shiro Fruits, Shunlan, Ginger (Ginger), Jouzan Hydrangea (Tsuneyama), Shobu (Iris, Iris root), Shozuku (Fruits), Shirakashi (Seeds), Silane (Byanchu), Shirogoshi Butterflies (Seeds), White clover (Clover), White adzuki bean (chicken bone grass), white bean iris (small iris), white beetle `` flower '', white nananthen (minamiminami), cinchona sacyl bra, ginkgo biloba (mizuka, mizukahana, kenchohana),
Cinnamon, Cinnammom Cassia (cinnamon bark), watermelon
(Watermelon), honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acid pattern), swimberry `` fruit '', star apple, stevia, strawberry `` fruit '', tin psycho (Xu Cho Lord), sugina (question thorn), suberhide (horse ken, Kento), plum "fruit", sulgaran (orange), Pinus sylvestris "cones", larch, vegetative leaves, horned walnuts, hawthorn, eucalypt, dandelion, horse chestnut (malonie), and pear berries ”
(Elder), Atlantic shrew (Juniper, Juniper), Achillea millefolium (Mirfoil), Atlantic rose, Atlantic anemone butterfly, Atlantic mistletoe, Atlantic mint or Atlantic mint, Horseradish, Sekisho
(Iris), Sec. Celery, Senkyu (River Kyu), Senshinren (Senshinren), Sendan, Sennin Cactus, Senna `` Fruits, Leaves '', Senninsou (Large Tate), Senburi (Drugs), Senboku, Soka
(Grass), Elephant Chestnut, Soshinwabai, Buckwheat `` seed '', Soybean Potato, Rhubarb (Ohaku), Radish, Soybean, Daidai (Orange skin, Kikomi), Takasagouri Rigogotai (Southeast Aizashi), Takasaburo (Dried Lotus), Takatodai (Daigei), Takawarabi (Inu), Dark Sweet Cherry `` Fruit '', Tachiaoi, Tachijakosou (Thyme, Momoka), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` seed '', Onion, Tamashiba (Spirit), Taranoki Fruits, leaves, root bark ",
Tarayou (Oba Fuyu, Ichiyocha, Kuchocha, Malancha), Dahlia
(Tengiku button), Talwi, Tanshiniwa, Tanjin
(Dan ginseng), Dandelion (Bakakohide) or White dandelion or Moko dandelion, Dammar, Cherry `` fruit '', Chigaya `` fruit, root, bud '', Chikusetsu carrot (bamboo ginseng), chicory, chancapiedra (Kidachiko Mikansou), tulip, Choconostay, Korean Radish (Rhuanghuang), Korean Radish (Wuyi), Korean Artemisia (Aiba), Choreimaitake (Irei), Chorogi, Tsukimiso, Tsukusushikaneran, Tsukuritake (mushroom), Tsuchiakebi, camellia, camellia, clover Lacquer mother grass), asiatic dayflower (duckling primrose), vine adzuki (red azuki bean), tsurutsuchiakebi, tsuldokudami (what a crow), tsuruna (ban apricot), tsurin carrot (four leaf ginseng),
Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tengusa, Tencha (Tencha), Tendaiyaku (Cowflower), Touga (Winter melancholy), Touoka Kazura, Capsicum (Pan pepper), Touki (Toki), Tokinsenka (Marigold) ), Tounabena (river cut), corn or corn hair (Nanban hair), horned rice mochi (female child), tourindo or Korean gentian (dragon bile), tokusa (pirate), dokudami (tenyaku), konkon (tokonomi), Toshishi or Mamedaoshi or Pear Kazura, Eucommia (Tonaka `` bark, leaves, roots ''), Ash (Qin bark), tomato, tragacanth, triacanthos `` seed '', turkey, tormentilla, dronoki, trollo aoi, tonkame, nigeria berry `` fruit '', Chinese yam or yam (Yamayaku), Nagikadida (Butcher Bloom), Naginata Kouju, Nazuna, Nata Ne, natto bean or mandarin (sword bean), jujube, jujube (daijutsu),
Naniwaibara (Kanekurako), Navena (intermittent), Nameko, Peanut (peanut), Nanten (Minami Tenmi), Namambaramushi
(Ramie), scented violet, nigaki (bitter tree), sagebrush (bitter mushroom), nutmeg, kei or nikkei or ceylon nikkei or yab nikkei (cinnamon bark) or keiseki (keishi), nymphalidium, leek (herringbone), elderberry (bone bone) Tree "fruits, flowers,
Stalks and leaves ''), garlic (garlic), nurde (five times), leek,
Nemunoki or Nebu or Nebi or Nemurinoki or Jigokubana (Happiness), Nozami (Daichi), Noybara (Fruit), Nozuka Kazura (Ryoshohana), Nototo, Yarrow, Nodake
(Maehu), novara, peach, pineapple `` fruit '', hibiscus (Bussouge, Furinbusouge, Roselle), Hyindou, Hauchiwa, Pau Dosse, Hakaumauraboshi (bone-breaking supplement), Hakukayumato, Hakusanchidori,
Hachsen (ringworm skin), huckleberry `` fruit '', chickweed (red lotus), hazel (haruko), hasiridokoro (roth root), basil, lotus (lotus, lotus, lotus), parsley (holland jellyfish), hadakamugi, batata, hachiku Or Madake (bamboo-boiled), patchouli, mint (lightly loaded, lightly-leaved leaves), barley (yokuinin), hanasuge (chimbo), banana, hanamint, hamabishi (siturishi, shisitsuri), vanilla bins, papaya, scotweed
(Rat malt grass), pahalobobo, hub `` whole plant, stem, leaf '', paprika, hakimakiran, hamagou or honeysuckle mackerel (vine troglodytes), hamabishi (ritsuko), hamanas (maikai flower), hamabafu (hamaki wind), hamamelis , Palm, rose (rose), balata, balata rubber tree, agaric (aragaric,
White agaricus, Usukimori no kasa), Haran, Pariurus (Pleurotus japonicus), Parietaria, Harkanran, Balsamina (Tsurureishi, Nigari), Harunile
(Yu bark, Yu white bark, Yu leaf), Barbasco, Harindou, Handaikai (Mt.Dai), Breadfruit, Hiougi (shadow), Hikagetsuru carrot (party party), Pecan nut, Higanbana
(Shirubi, Suzuka Hana), Higuru Madaria, Higotai, Hishi
(Hishimi), pistachio, beet, hitsuba (stone reed), hitspotter, daisies (daisy), hinotakozuchi
(Cow Knee), Hinomi bulbul, Hinoki, Hiba, Castor, Sunflower, Bell Pepper, Himeuzu (Tama Aoi), Himegama (Kagami), Himematsutake (Kawariharatake, Hiromatsutake), Himemyouran, Pimenta `` Fruit '', Juniper, Bjakuyu, Hyyu Fruits, Biloba oi, Hiroha okinagusa (Hakuto Okina), Loquat `` Fruits, leaves, stems '', Betel nut (Large coat, betel nut), Puer tea, Houtou kazura (Southern rattan), Butterfly, Betula dandelion (Winter flower, Winter leaf) , Fujibakama (Orchid), Fuji Bean (Tanboshi), Fujimodoki (Costrus japonica, Citrus), Grape `` Fruits, pericarp, seeds, leaves '', Beech, Fumusinatsutaketake (Cordyceps), Brazilian Licorice, Brazilian Carrot,
Black currant "fruit", blackberry, blanin, plum "fruit", flucellaria, prune, floral blanka, blond psyllium, bundou (green bean), hazelnut, loofah, hetsukaran, safflower
(Safflower), Henneken, Belladonna, Berry `` Fruit '', Persea, Perbianberg, Perescia grandifolia, Benikeaiso or Lemna (Keiten), Boysenberry `` Fruit '', Broomweed or Elderweed or Nendow or Haeukigi Kokia ), Hosairan, Balsam
(Hosen, acute offspring, osteophyte), Potteria sapota, Potteria lukuma, spinach, boufu (windbreak), spinach, physalis (Torone), honoki (wakopoku, park), bokeh
(Gourd), Hosoba Aburagiku (bitter gourd), Hosoba Oguruma,
Hosovanaokera (Aojutsu), Hosobanokirinsou (Kageten 37), Hosobabarengiku, Bodaiju (Bodaiju), Button
(Peony `` flowers, leaves, stems, bark ''), buttonpies (peony bark), hops, jojoba, borage (ruriichisha), bordeaux, white berries `` fruits '', hon-onik (meat porcelain, daigei), hon-sekko (iron Skin stone mackerel, sparrow mountain stone mascara), myzurutennanshaw (Tenan star), maitake (maitake), ephedra (mao), maca, macadamia nut, margaret (mokshungiku), macri (seaman grass), maguwa (mulberry white bark) `` Bark, leaves ''), Magnolia splengeri, Masaranpouba, Masaranzuba do Ceara, Masheira de Boi, Masahua (Tamanouzenhallen, Cucumber kinrenka), Matatabi (Kiten Tate), Matsukasa, pine `` leaves, bark, Roots, Matta Oryo, Matsuhodo (Bukuryo), Matico (Cordoncillo), Mayorum (Hanamint), Malvanojadine (Bitterfruit), Mulberry "Fruit", Quince, Murray (Below mou watermelon), mango, mangosteen, mansagna (andesukamitsure), mansugurumi, mandarin `` fruit '',
Mannentake (Lingzhi), Pheasant (Kikomi `` fruits ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi),
Mizokokushi (half-edge lotus), Mihohagi (Chisatsuna), Mycian willow or Japanese willow (Henryoku), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Miyoka, Miracle fruit `` fruit '', Myrrh, Mirobaran, Mugiwaragiku, Mukuge (Mokuge) , Mukunoki, Mukuroji (prolonged skin), Munya, Purple (purple root), Purple or purple
(Purple beads), purple corn, purple purple (Kunming chicken blood wisteria), megakanza opuntica, red seaweed (mother grass), red seaweed, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (pepper blossom), ilex, peach blossom, peach (peach `` leaves, seeds, flowers, fruits ''), bean sprouts, morello cherry `` fruit '', moroheiya (burlap), Yakawamurasakiimo, yakuchi (masuchi), cornflower (cornflower),
Cornflower, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabushi `` fruit, peel, kaho '', yachiyanagi, yatsude (octagonal plate), mistletoe (willow parasitism), willow (kawayanagi, tachiyanagi, weeping willow,
Red Willow, Pussy Willow, Pussy Willow, Kinuyanagi, Kolyanagi, Unryuyanagi, Miyayamayanagi, Palm, Yamanagi, Obayanayanagi, Tairikkinyanagi,
(Sweaty willows and stalks), willow litter `` leaves and stems '', yabugarashi, yabukouji (purple gold beef), yabu tobacco (crane squirrel, tenna sperm), pokeweed (commercial land), yamahanoki (yamaharu), yamamomo (yumemei), yamamogi, Eucalyptus, Saxifraga (tiger eargrass), Yucca or flevifolia, Yuzu `` fruit '', lily, yorogusa, mugwort (Aiba), ligan (Rainuma), lime `` fruit '', rye, lacanca `` fruit '', raspberry `` leaf, fruit '', Latania (Crameria), Rakkyo or shallots (scallop), lavender, longan (longan meat), agave (Aono agave, fukurin agave), ryocha (green tea), apple `` fruit,
Seeds, leaves, roots ", gentian, rubus or suavisimus
(Sweet), Ruritama thistle (Urajirohigotai, Xinjiang indigo head), litchi (Lichi, lichi nucleus), lettuce (Chisha), red currant `` fruit '', red pitaya, lemon `` fruit '',
Lemongrass, forsythia or Chinese forsythia,
Astragalus, waxby, wax palm, rocon, reed, loganberry `` fruit, '' rosemary, mannenroe, rosehip, nobara, wasabi, cotton azalea, miromengou And the like.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), Anaaousa (Aosaa), seaweed [Aosa] Kinds: Kombu (Macambu, Rishikonbu, Hosomekombu, Mitsuikonbu), Wakame, Hirome, Ao-Wakame, Giant kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuki prickly pear, Echinoki prickly pear], seaweed [red algae: red alga: Hijirimen, maxa (Tengusa), hirakusa, oniku , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Junyashinkirinsai, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kuwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanoli, Juzumo
Species of the genus Mizudzumo, Genus Genus, Genus Colecaetus, Genus genus Tsutsumo, Artemisia spp .: Artemisia spp.

Cyanobacteria (Genus Lynx: L., L., L., L .;
(Hassay, genus genus, genus racenmo (spirulina): spirulina, genus trichodesmium (aiakacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Icmegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulumimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russula genus: Rush genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himebiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabo kintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Scutellariae, Osmanthus Nagaobabane: Nagaobane,
Genus Funori: Hanafunori, Fukurofunori, Makunori, Kalexigusa: Kalexigusa, Sasamodoki: Hosobanotosakamaki, Hirohanokasakamuki, Yatsudegatatasakamoki, Kurosakamaki, Nezashinosakamukado, Yukasakanookado Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenija, honooo genus: honoo, genus genus: lyca genus, genus genus, genus nikonobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurusilamo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Amanita: Hachijoenaga, Fushikenori genus: Fushikenori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Saimi genus: Itanigusa, Simi, Harigane, Lotus genus:
Lotus lotus, genus genus: squid
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishbukuro, Madaragusa: Togemadara, Echimadara, Taoyagousou: Genus Ottawa, Scrophularia , Hirata goat: Hirata goat, Darus: Darus, Masagoshibari, Anadals, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushinagi: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi, Snapdragon
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usbeni: Usveni, Hasuginu: Hasuginu, Nagakonohanori: Nagakosugino, Genus: suginanu Yaleusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki genus: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia genus: Enashidazia, Simadadia genus: Isohagi, Shimadada, Dazimodoki genus: Daziomomodoki, Itogusa genus: Moletogusa, Futoigusa, Macri genus: Macri, Yanaginori genus: Hanayanagi, Yuna, Sanaginori, Mosanyugina, Sasa, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshig, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Hatakesakinokokihiba, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

The axle algae (Charus spider, Shiratamamo,
Hossiturimo: Hossiturimo, Lichnotumnus, Phalaenopsis: Himejira, Chaboflavidium, Tripera etc., Yellow algae (Hikarimo: Hikarimo etc.) and the like.

Materials derived from animal raw materials include cockscomb extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or its degradation product, cow or pig Extract of brain tissue, collagen water (acid, alkali,
Enzymes, etc.) Decomposed products, collagen derivatives such as water-soluble collagen or acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposed products or their derivatives, silk proteins and their degradation Products or derivatives thereof, swine or bovine blood cell proteolysates (globin peptides), bovine or swine hemoglobin hydrolysates (hemin, hematin, heme, protohem,
Heme iron), milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) )
etc.

Examples of the material derived from plant or animal materials include any site derived from a genetically modified product or a cell fusion.
Cells, tissues, organs, metabolites and the like can also be used.
Furthermore, for example, undifferentiated cells or cells undergoing differentiation, which are obtained by culturing cells at any site, cell, tissue, organ, or the like, can also be used.

(14) Marine components Seawater such as deep water, for example, seawater salts, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud Or mud (Fango) s, for example, sea mud or mud (constituents: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, iron oxide, manganese oxide, sodium oxide, etc.) such as Italian fango, German fango, Eifelfango, Freiburgfango, etc. Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc.

(15) Microbial culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Rice fermented extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermentation product of raw milk or skim milk powder, and the like.

(16) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) UV absorbing / blocking agent benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc., para-aminobenzoic acid derivatives ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazolines Derivatives, pyrimidine derivatives,
Dioxane derivatives, camphor derivatives, furan derivatives,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escalol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening Agents Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and the like.

(20) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside or the like), hydroquinone or a derivative thereof (hydroquinone benzyl ether or the like), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, warmoko,
Clara, mugwort, honeysuckle, yellowfin, amberjack, matsuhodo, adlay barley, odorisium, hops, hawthorn, eucalyptus, achillea millefolium, althea, keihi, mankeishi, hamamelis, yamaguwa, extended life grass, bellflower, toshishi, maizeko, sun dried, mao, (Sengyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Genoshoko, Kakkon, Licorice, Gotobiko, Aloe, Shouma, Safflower, Green Tea, Black Tea, Asenyaku).

(21) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemblage, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley) etc.

(23) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (cultured cells of sesame, amateur,
Hypericum, Hamamelis, Clover, Melissa, Emisoso, Birch, Salvia, Rosemary, Minami Tenji, Agetsu, Ginkgo, Green Tea) and the like.

(27) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, sicon extract, age extract, propolis and the like.

(28) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, propionic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoates, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (Polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.), cationic surfactant (odor, etc.) Cetyltrimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin, propolis, etc. .

(29) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidone carboxylic acid or its Salt, Sodium Lactate, Mini Sasanishiki Extract, Bacillus Natto Metabolite, Natto Extract, Loofah Water, White Birch or Akamatsu Sap

(30) Inhibitors of elastase activity diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, salvia, western elderberry, bollige, buttonpi), seaweed extracts and the like.

(31) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(32) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(33) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placental extract, biotin, glyceride pentadecanoate and the like.

(36) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract and the like.

(39) Hair remover strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like;

(40) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(41) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonic acid sodium salt, hematein and the like.

(42) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Greater Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, camphor essential oil, mandarin essential oil, Eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(43) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and the like.

(44) Others Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers,
Vegetable protein and its degradation products, animal and vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound healing agents, Foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), oral agents, deodorants / deodorants, bittering agents, seasonings, etc. are raised. An additive or synergistic improvement of the inventive or other cosmetic effects can be expected.

The method for adding the melanin production inhibitor and the cosmetic composition of the present invention to the cosmetic composition may be added in advance or during the production, and may be appropriately selected in consideration of workability. good.

[0076]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Preparation Example 1) 100 g of various dried plants such as Itohime-hagi, Umano-sakusa, Arasubi-shaku, lingonberry, corn bean sprouts and hamazuge are heated and extracted with purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dried) Solid content: about 0.1 to 2.5
%) Of about 1.0 kg.

(Production Example 2) 100 g of various dried plants such as Itohimegagi, Umanozukusa, Raspberry shark, lingonberry, cornflower, and hamazuge were immersed in a 50% ethanol solution.
After extraction at room temperature for 5 days and nights, filtration is performed to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 2.5%).

(Production Example 3) 100 g of various dried plants such as Itohimegagi, Umano-sakusa, Raspberry prunus, lingonberry, corn bean sprouts, and hamazuge were placed in a 70% ethanol solution or 70%
Immerse in 3-butylene glycol solution, 60% propylene glycol solution, or purified water (about 30 ° C)
After extraction day and night, filter and extract (dry solids: about 0.1
~ 3.0%).

(Test 1) Melanin Production Inhibition Test "Test Method and Evaluation Method" B16 melanoma cells were cultured for 24 hours, and this culture solution was replaced with a culture solution containing a sample. At this time, purified water was added to the blank. After culturing for 3 days, the cells were treated with trypsin and 10% DM
It was dissolved by heating in a 1N-NaOH solution containing SO, and the absorbance at 420 nm was measured. At the same time, the MTT reduction method (Tim Mosmann; Jou
rnal of Immunological Methods p55-63 (1983))
After confirming that there was no difference in the number of surviving cells between the blank group and the sample-added group, the inhibition rate (%) of the blank cells against the amount of melanin production was determined by Equation 1.
The results are shown in FIG. "Sample" A sample for the melanin production inhibition test was subjected to the test using the extract (solid content concentration: adjusted to 0.025%) obtained in Production Example 2 of the present invention. As a comparative sample, arbutin (manufactured by Sigma) was prepared under the same conditions and used for the test.

<Equation 1> Melanin production inhibition rate (%) = {1− (sample melanin amount / flank melanin amount)} × 100

(Test Results) As shown in FIG. 1, it was found that Itohimehagi, Umano Sakusa, Raspberry, Cowberry,
Compared with arbutin, various plant extracts of the nutsedge can be confirmed to have a strong or almost equivalent melanin production inhibitory action, and can be used as a whitening agent.

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared in purified water so that the dry solid concentration was about 0.5%. This was applied to the skin of a Japanese white rabbit (female, 3 animals per group, weighing about 2.3 kg) whose back was shaved. At 24, 48, and 72 hours after application, evaluation was performed using erythema and edema as indices based on the criteria of Draize. As a result, no erythema and edema were observed in all animals, and it was judged that there was no problem with regard to primary skin irritation.

(Test 3) Safety test (2) Skin cumulative irritation test Similarly, the various plant extracts obtained in Production Examples 1 to 3 were purified water-purified so that the dry solids concentration was about 0.5%. Hartley guinea pigs prepared and shaved on the back (female, group 3
Once a day, 5 times a week, 0.5 mL
/ Animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria of Draize on each application day and the day after the last application day. The result is 2 in all animals.
No erythema and edema were observed over the week, and it was judged that there was no problem with respect to the cumulative skin irritation.

(Test 4) Safety test (3) Single dose toxicity test The various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%. kg quantity,
Before the test, ddy mice (male and female, 5 animals per group, 5 weeks old) which had been fasted for 4 hours were orally administered, and the appearance and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined that the substance was safe.

(Prescription examples) Production of melanin production inhibitor and cosmetic composition The following prescription examples are shown below according to the above evaluation results. Each prescription example may be one produced by a conventional method in the production of each product. , Only the blending amount is shown. Further, the present invention is not limited to these.

(Formulation Example 1) Emulsion weight% 1. Squalane 5.0 2. Olive oil 5.0 3. Jojoba oil 5.0 4. Cetyl alcohol 1.5 5. Glycerin monostearate 2.0 6. Polyoxyethylene (20) cetyl ether 3.0 7. Poly Oxyethylene (20) soorbitan monooleate 2.0 8.1,3-butylene glycol 1.0 9. Glycerin 2.0 10. A: Extract of Echinacea purpurea of Production Example 2 B: Extract of Echinacea japonicus of Production Example 2 C: Extract of Raspberry crab of Production Example 2 Liquid D: Cowberry extract of Production Example 2 E: Leaf extract of Production Example 2 * Any one of A to E extract 5.0 11. Preservative (paraoxybenzoic acid ester) qs 12. Fragrance qs 13. Water 100 and the rest

(Formulation Example 2) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Magnesium salt of vitamin C phosphate ester 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monooleate 2.0 10.1,3-butylene glycol 1.0 11. Glycerin 2.0 12. Itohimemegi fruit or fruit 30% Ethanol extract 3.0 13. 30% Echinacea fruit or crust ethanol extract 3.0 14. Water extract of swine placenta 3.0 15. Preservative (p-hydroxybenzoate) qs 16. Purified water 100 residue

(Formulation Example 3) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Grapefruit fruit or leaf hot water extract 3.0 6. Tochu leaf hot water extraction Liquid 3.0 7. Raspberry rhizome tuber or rhizome 30% ethanol extract 3.0 8. Cowberry peel or fruit 30% ethanol extract 3.0 9. Olive oil 1.0 10. Shea butter 1.0 11. Butylhydroxyanisole 0.1 12. Vitamin E derivative 0.1 13. Preservative Agent (benzalkonium chloride) suitable amount 14.Fragrance (tokisui) suitable amount 15.purified water 100 residue

(Formulation Example 4) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Nutsedge tuber or rhizome 30 % Ethanol extract 1.0 6. Green tea leaf or stem 30% ethanol extract 1.0 7. Grape stem or leaf 30% ethanol extract 1.0 8. Pepper peel or fruit 30% ethanol extract 1.0 9. Kiwi fruit 50% ethanol extract 1.0 10. Antibacterial and preservative (lactoferrin solution) suitable amount 11. Fragrance (Western thin water) proper amount 12. Purified water 100 residue

(Formulation Example 5) Astringent lotion weight% 1. Sorvit 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Itohimehagi whole plant 30% glycerin extract 3.0 5. Yeast 50% 1,3- Butylene glycol extract 2.0 6. Soapwort leaves 50% 1,3-butylene glycol extract 2.0 7. Orange peel 50% ethanol extract 1.0 8. Allantoin 0.2 9. Astringent (zinc sulfocarbonate) 0.2 10. Antibacterial and preservative (Thiamine lauryl sulfate) Appropriate amount 11. Fragrance (lavender water) Appropriate amount 12. Purified water 100 residue

(Formulation Example 6) Two-layer type lotion (liquid to liquid type)% by weight 1. Squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. Sorbit 1.0 4. Ethanol 15.0 5. Rhododendron rhizome or root bark 50 % Propylene glycol extract 2.0 6. Murasaki (purple root) 50% propylene glycol extract 2.0 7. Lemon fruit 50% propylene glycol extract 2.0 8. Western lime tree flower or leaf 50% propylene glycol extract 1.0 9. Production Example 1 Astragalus extract liquid 2.0 10. Astragalus extract liquid of Production Example 1 2.0 11. Ascorbic acid 0.2 12. Astringent (calamine) 0.1 13. Preservative (phenoxyethanol) qs 14. Fragrance (lemon water) qs 15. Purified water 100 Residue

(Formulation Example 7) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Phenoxyethanol 0.1 5. Iron oxide (Bengara) 0.2 6. Zinc oxide 0.5 7.Kaolin 2.0 8.50% Propylene glycol extract of Spiraea flower 50.9. Cucumber fruit 50% propylene glycol extract 2.0 10.U.S.a. flower or leaf 50% propylene glycol extract 2.0 11.Kamotori flower 50% propylene glycol extract 2.0 12.Itohimemegi whole plant 50% propylene glycol extract 2.0 13.Phaseolus rhizome 50% propylene glycol extract 2.0 14.Pot placenta enzyme decomposition extract 1.0 15.Camphor 0.2 16.Phenol 0.03 17.Preservative (Photosensitizer 201 & 401) 18.Perfume (Bodhi tree water) Appropriate amount 19.Purified water 100 residue

(Formulation Example 8) Pack weight% 1. Polyvinyl alcohol 15.0 2. Sodium carboxymethyl cellulose 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Echinacea rhizome 50% 1,3-butylene glycol extract 1.0 6. Cowberry 50 % 1,2-pentanediol extract 1.0 7. Calendula whole plant 50% glycerin extract 1.0 8. Sweet tea whole plant 50% glycerin extract 1.0 9. Satsuma mandarin peel 50% glycerin extract 1.0 10. Preservative (paraoxyl) Benzoic acid ester) Appropriate amount 11.Fragrance (apple water) Appropriate amount 12.Purified water 100 residue

(Formulation Example 9) Peel-off pack% by weight 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Whole plant 70 % Ethanol extract 2.0 8. Psyllium whole plant 50% ethanol extract 2.0 9. Dutch jelly (parsley) leaf or stem 50% ethanol extract 2.0 10. Preservative (phenoxyethanol) qs 11. Fragrance (cypress leaves or bark water) qs 12.Remaining with 100 purified water

(Formulation Example 10) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Parietaria leaf extraction Liquid 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 9.Birch bark extract 2.0 (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10.Gennoshoko whole plant extract 2.0 ( Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 11.Ranunculus rhizome extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 12.Naturus rhizome extract 2.0 (ethanol: 1, 3-Butylene glycol = 1: 1 extraction solvent) 13. Liquid shea fat 1.0 14. Preservative (acrinol) 0.1 15. Perfume (apricot water) qs 16. Purified water 100 residue

(Formulation Example 11) Emollient cream weight% 1. stearic acid 2.0 2. stearyl alcohol 7.0 3. reduced lanolin 2.0 4. squalane 5.0 5. octyl dodecanol 6.0 6. polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Raspberry extract extract of Production Example 3.0 10. Hot water extract of dokudami leaf 3.0 11. Tomato fruit hot water extract 3.0 12. Clara whole plant hot water Extract 2.0 13. Preservative (paraben) qs 14. Fragrance (loofah water) qs 15. Residual to make purified water 100

(Formulation Example 12) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Itohimehagi whole Grass 20% 1,3-butylene glycol extract 2.0 8. Saxifraga whole plant extract 2.0 (ethanol: 1,3-butylene glycol = 1: 2 extraction solvent) 9. Rose flower or fruit 20% 1,3-butylene glycol Extract 2.0 10. Yasabushi whole plant 20% 1,3-butylene glycol extract 2.0 11. Walnut husk powder 2.0 12. Bifidobacterium fermented liquid 1.0 13. Dipotassium glycyrrhizinate 1.0 14. Preservative (salicylic acid) 0.1 15. Perfume (lavender water) Appropriate amount 16. Residual water with 100 purified water

(Formulation Example 13) Face wash cream weight% 1. stearic acid 10.0 2. palmitic acid 10.0 3. myristic acid 12.0 4. lauric acid 4.0 5. oleyl alcohol 1.5 6. lanolin derivative (EO adduct) 1.0 7. glycerin 18.0 8. Potassium hydroxide 6.0 9. A: Extract of Echinacea purpurea of Production Example 2 B: Extract of Echinacea japonicus of Production Example 2 C: Extract of crow stalk of Production Example 2 D: Extract of lingonberry of Production Example 2 E: Production Example 2 Extract of any one of A to E 5.0 * Royal jelly extract 1.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 11. Glycyrrhetinic acid 1.0 12. Preservative (salicylic acid) 0.1 13. Appropriate amount of fragrance (mugwort water) 14. Residual amount of purified water 100

(Formulation Example 14) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Echinacea fruit 70% 1,3-butylene glycol extract 1.0 5. Wakame 70% 1 , 3-Butylene glycol extract 0.5 6.Merilot flower or leaf 70% 1,3-butylene glycol extract 0.5 7.Amachiro leaf or stem 70% 1,3-butylene glycol extract 0.5 8.Polyethylene powder 0.5 9.Hydroxy Propyl chitosan solution 0.5 10. Amino acid (arginine, glycine, glutamine, etc.) 0.5 11. Preservative (undecylenic acid, phenol) proper amount 12. pH adjuster proper amount 13. Perfume (lemon water) proper amount 14. Purified water 100 residue

(Formulation Example 15) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Ethyl polyacrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 1.0 12. Titanium dioxide 5.0 13. Cowberry fruit or pericarp 70% 1,3 -Butylene glycol extract 0.5 14. Raspberry rhizome 50% dipropylene glycol extract 0.5 15. Loquat leaf 50% dipropylene glycol extract 0.5 16. Sandalwood whole plant 50% dipropylene glycol extract 0.5 17. Preservative (paraben) Appropriate amount 18.Fragrance (apple water) Appropriate amount 19.Residual water to be 100

(Formulation Example 16) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 22.5 5. Hamazuge rhizome 50% dipropylene Glycol extract 1.0 6. Roman chamomile flower 10% 1,3-butylene glycol extract 1.0 7. Burdock root 50% 1,3-butylene glycol extract 0.5 8. Teuchigurumi peel or leaf 30% 1,3-butylene glycol extraction Liquid 0.5 9. Whole barley whole plant 50% 1,3-butylene glycol extract 0.5 10. Fencil fruit 30% 1,3-butylene glycol extract 2.0 11. Appropriate amount of antioxidant (butylhydroxytoluene) 12. Perfume (cornflower water) ) Appropriate amount

(Formulation Example 17) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11.2,4-dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Color pigment (iron oxide yellow) 1.0 15. Itohimehagi fruit or pericarp Hot water extract dry powder 0.2 16. Tencha hot water extract dry powder 0.2 17. Yakuyo salvia hot water extract dry powder 0.2 18. Preservative (phenoxyethanol) qs 19. Flavor (cardamom water) qs 20. Purified water 100 And the rest

(Formulation Example 18) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Echinacea rhizome rhizome 20% 2,3-butylene glycol extract 2.0 7. Eucalyptus hot water extract 2.0 8. Button 30% 1,4-butylene glycol extract 2.0 9. Toki root 30% 1,4-butylene glycol Extract 1.0 1.0 Hydroxypropyl chitosan solution 2.0 11. Mucopolysaccharide solution 1.0 12. Antibacterial and preservative (photosensitizer No. 101) qs 13. pH adjuster qs 14. Fragrance (sandalwood water) qs 15. Purified water 100 Residue to do

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Whole plant of lingonberry and 50% glycerin extract of rhododendron rhizome 1.0 6. Assemble leaf or stem 50% 1,2-butylene glycol extract 1.0 7. Eustoma flower 50% 1,2-butylene glycol extract 1.0 8. Coltsfoot flower or leaf 50% 1,3-butylene glycol extract 1.0 9. Hydroxyethyl chitosan solution 1.0 10. Trehalose solution 1.0 11. Hydrolyzed silk solution 1.0 12. Antibacterial and preservative (benzalkonium chloride) qs 13. perfume (lavender water) qs 14. Purified water 100 Residue

(Formulation Example 20) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6. Hamazuge whole plant 50% 1 , 3-butylene glycol extract 1.0 7. Olive seed 50% 1,2-pentanediol extract 1.0 8. Kuma bamboo leaf 30% ethanol extract 1.0 9. Trehalose solution 1.0 10. Hydrolyzed keratin solution 1.0 11. Antibacterial・ Preservative (benzalkonium chloride) appropriate amount 12.Fragrance (chamomile water) appropriate amount 13.Residual water to be 100 purified water

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Echinacea fruit and rhizome 50% ethanol extract 2.0 6. Hops spikes 50% ethanol extract 1.0 7. Melissa whole plant 50% ethanol extract 1.0 8. Carpronium chloride 0.3 9. Hinokitiol 0.5 10. Keratin decomposition solution 1.0 11. Antibacterial and preservative (paraben, benzalco chloride) Ni) Suitable amount 12. Fragrance (Angelica water) Appropriate amount 13. Residual amount to be 100 purified water

(Formulation Example 22) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Trimethylene glycol 5.0 6. Cowberry fruit and Skin 50% 1,3-butylene glycol extract 1.0 7. Lemon fruit 50% 1,3-butylene glycol extract 0.5 8. Apple fruit 30% ethanol extract 1.0 9. Azulene 1.0 10. Antibacterial and preservatives (paraben, Benzalkonium chloride) Appropriate amount 11. Fragrance (jasmine water) Appropriate amount 12. Purified water 100 residue

(Formulation Example 23) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Itohimehagi extract of Production Example 2 B: Production Example 2 C. extract of Echinacea japonicus C: Raspberry extract of Production Example 2 D: Berry extract of Production Example 2 E: Leaf extract of Production Example 2 * Extract of any one of A to E 5.0 5. Comfrey leaf or Stem 50% ethanol extract 3.0 6. Lettuce leaf 50% ethanol extract 3.0 7. Dipotassium glycyrrhizinate) 0.1 8. Preservative (phenoxyethanol) 0.1 9. Purified water 100

(Formulation Example 24) Hair tonic weight% 1. l-menthol 0.2 2. Ethanol 32.5 3. Polyoxyethylene hydrogenated castor oil 0.5 4. Propylene glycol 5.0 5. Diphenhydramine hydrochloride 0.3 6. Itohimehagi whole plant 50% propylene glycol Extract 2.0 7. Pepper fruit hot water extract 1.0 8. Below oil rhizome or root bark 50% ethanol extract 1.0 9. Japanese gourd rhizome or root bark 50% ethanol extract 1.0 10. Citrus rhizome or root bark 50% ethanol extract Liquid 1.0 11. Carboxymethyl chitin solution 1.0 12. Vitamin E derivative 0.5 13. Antibacterial and preservative (paraben) 0.1 14. Appropriate amount of fragrance (Ylang-ylang water) 15. Purified water 100

(Formulation Example 25) Hair restorer / hair restorer% by weight 1. Ethanol 60.0 2. 50% glycerin extract from Hydrangea 5.0 3. 2,3-butylene glycol extract from 50% whole plant of Echinacea 2.0 4. Vitamin E derivative 0.5 5 Pepper tincture 0.5 6. Resorcinol 0.5 7. Dipotassium glycyrrhizinate 0.5 8. Carboxymethyl chitin solution 0.5 9. Porcine hematin solution 0.5 10. Porcine mucin solution 0.5 11. Amino acids (arginine, glycine, glutamine, etc.) 0.5 12. Antibacterial and antiseptic Agent (paraben) 0.1 13.Fragrance (Western thin water) suitable amount 14.Purified water 100 residue

(Formulation Example 26) Hair restorer / hair restorer (% by weight) 1. Ethanol 60.0 2. Extract of 60% diglycerin extract from Rhizoma rhizome 1.0 3. Extract of 60% ethanol apricot whole plant 1.0 4. Extraction of iris rhizome or root bark 60% ethanol Solution 1.0 5. Cantaris tincture 0.5 6. Pantothenic acid derivative 0.5 7. Glycyrrhetinic acid 0.5 8. Resorcinol 0.5 9. Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12. Antibacterial and preservative (phenoxyethanol) 0.1 13. Appropriate amount of fragrance (bergamot water) 14. Residual amount of purified water 100

(Formulation Example 27) Granule bath agent weight% 1. Sodium hydrogen carbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4. Dry powder of Itohimehagi extract of Production Example 1 5.0 5. Drying of hot water extract of Senkyu Powder 8.0 6. Jujube whole plant hot water extract dry powder 2.0 7. Pigment (Gunjo green) Appropriate amount

(Formulation Example 28) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4. Dry powder of the extract of the lavender extract of Production Example 3.0 5. Mulberry bark hot water extraction Liquid dry powder 1.0 6. Kawataya leaf hot water extract dry powder 1.0 7. Satsuma mandarin peel 50% ethanol extract dry powder 1.0 8. Iris or root 70% ethanol extract dry powder 1.0 9. Apple juice powder 1.0 10. Dye (Gunjo, chromium hydroxide) Appropriate amount 11. Fragrance (Roman chamomile water) Appropriate amount

(Formulation Example 29) Coating protective agent A gauze or liniment cloth is impregnated with a prescription solution prepared by mixing an appropriate amount of a hot water extract of a mustard rhizome and a hot water extract of a rhizome rhizome, an antibiotic, an anti-inflammatory agent, etc. Attach to In addition, the hot water extract of Rhizopus rhizome and the hot water extract of Rhizoma rhizome may be directly sprayed locally and covered with gauze or the like.

(Formulation Example 30) Oral freshener weight% 1. Ethanol 20.0 2. Glycerin 15.0 3. Polyoxyethylene hydrogenated castor oil 1.0 4. Saccharin 0.2 5. Chlorohexidine 0.01 6. Dry powder of Itohimehagi extract of Production Example 1 0.1 7.Dried powder of the mustard extract from Preparation Example 1 0.1 8.Appropriate amount of pigment (Gunjo green) 9.Remaining to be purified water 100

(Prescription Example 31) Dishwashing detergent weight% 1. Alkyl (C12) glucoside 20.0 2. Polyoxyethylene (3) Na dodecyl ether sulfate 10.0 3. Glycerin 2.0 4. Ethanol 5.0 5. Extraction of horseshoe clover in Production Example 1 Liquid dry powder 3.0 6. Soybean hot water extract dry powder 3.0 7. Purified water 100 residue

(Test 5) Use Effect Test The effect of the cosmetic composition of the present invention actually used was examined. The use test was conducted by a panel of 30 persons aged 30 to 60 years old who were worried about spots, freckles, and black and white, twice daily in the morning and evening, and after washing the face, the appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. It was performed by coating. As a control, a mixture prepared by removing the various plant extracts of the present invention from the emulsion by the same method was used. The evaluation was performed according to the following criteria. The results are as shown in Table 1 and the numerical values in the table represent the number of persons. No one complained of skin abnormalities during the use period.

"Stain, freckles and skin color improving effect" Effective: The freckles, freckles and skin color were white and reduced. Slightly effective: White spots and freckles and skin color were slightly reduced. Ineffective: No change from before use.

[0120]

(Test results) As shown in Table 1, it was found that Itohimehagi, Umanosukusaku, Raspberry, Cowberry,
It has been confirmed that the emulsion containing various plant extracts of the nutsedge significantly reduces stains and freckles and also makes the skin color whiter, and can be used as a whitening agent.

(Test 6) Use effect test The effect of the cosmetic composition of the present invention actually used was examined. Use test is 25 healthy adult women
Thirty 50-year-olds are panelists, twice daily in the morning and at night,
After washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. As a control, a mixture prepared by removing the various plant extracts of the present invention from the emulsion by the same method was used. The evaluation was performed according to the following criteria. The results are as shown in Table 2 and the numerical values in the table represent the number of persons. still,
No one complained of skin abnormalities during the period of use.

"Effect of improving skin gloss and tension" Effective: Skin gloss and tension increased. Slightly effective: Skin gloss and tension increased slightly. Ineffective: No change from before use.

[0124]

(Test results) As shown in Table 2, it was found that Itohimehagi, Umanosukusaku, Raspberry, Betula,
It was confirmed that the emulsion containing various plant extracts of the nutsedge significantly increased the gloss and firmness of the skin.

[0126]

Industrial Applicability The melanin production inhibitor or cosmetic composition of the present invention containing one or more plant extracts selected from the group consisting of Itohimehagi, Umanozukumasu, Raspberry japonicus, lingonberry, hamazuge, significantly suppresses the production of melanin pigment,
It was confirmed that it had a whitening effect. And skin stains,
Improve freckles and whiten skin. In addition, the skin can be given a gloss and tension to prevent aging. The present invention can be used for other general foods and drinks.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a graph showing the inhibitory rates of various plant extracts of Itohimegegi, Echinacea japonicus, Araceweed, Betula peach, and Lepidoptera on melanin production.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/11 A61K 7/11 7/16 7/16 7/50 7/50 35/78 35/78 C A61P 43/00 105 A61P 43/00 105 (72) Inventor Yuka Tsuda 318-1 Asagi, Masamasa-cho, Motosu-gun, Gifu Prefecture F-term (reference) in Maru Falcos Co., Ltd. 4C083 AA03 AA072 AA082 AA111 AA122 AB032 AB082 AB212 AB232 AB242 AB272 AB312 AB352 AB432 AB442 AC012 AC022 AC032 AC062 AC072 AC082 AC102 AC112 AC122 AC152 AC172 AC182 AC242 AC252 AC342 AC392 AC422 AC432 AC442 AC472 AC482 AC532 AC542 AC552 AC582 AC642 AC682 AC692 AC742 AC782 AC792 AC852 AC862 AC902 AC932 AD112ADADADADAD AD452 AD512 AD532 AD552 AD632 AD642 AD662 BB23 BB41 BB44 BB48 CC04 CC05 CC06 CC07 CC12 CC25 CC28 CC32 CC37 CC39 CC41 DD21 DD33 4C088 AB12 AB44 AB54 AB79 AB80 BA08 BA09 BA10 CA05 CA08 MA63 NA14 ZA89 ZC41

Claims (2)

[Claims] 1. A melanin production inhibitor comprising at least one plant extract selected from Aedes aegypti, Echinacea japonicus, A. americana, Betula edulis, and Amaranthus. 2. A cosmetic composition comprising the melanin production inhibitor according to claim 1.