JPH11193219A - Hair growing and regenerating agent with formulated plant extract - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new safe hair growing and regenerating agent obtained from a plant. SOLUTION: This hair growing and regenerating agent contains a plant extract of at least one kind of moutan bark, linden, salvia, stevia, peony, comfrey, pachyma hoelen, scutellariae radix, Hypericum erectum, Pinellia ternata, cherry and Perilla frutescens crispa. The hair growing and regenerating agent has an excellent hair growing and regenerating activities and is safe to a human and an animal. The extract can be used for other common foods and drinks.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001] The present invention relates to a novel and safe plant extract selected from the group consisting of red bean pigs, bodice, salvia, stevia, peonies, comfrey, bukuro, ougon, hypericum, hanger, cherry and perilla. And a hair tonic and hair restorer containing the same.

[0002] The field of application can be used in all kinds of external preparations (including preparations for animals). Specifically, capsules, powders, granules, solids, liquids,
Gel or foamy 1) pharmaceuticals, 2) quasi-drugs, 3)
Topical or systemic skin cosmetics, 4) Medicinal and / or cosmetic preparations applied to the scalp / hair (eg, shampoos, rinses, treatments, permanent solutions, hair dyes, hair dressings, hair tonics) , Hair restoration, hair restoration, etc.)
Is raised.

[0003]

2. Description of the Related Art Hair greatly affects the appearance and occupies a very important position in beauty. Alopecia is still a matter of deep concern, with no precise cure. There are two types of alopecia, congenital and acquired. There are many studies on the causes and mechanisms of alopecia, but there are many unclear points. Currently, many are on the market.

At present, the causes of hair loss are considered to be due to abnormalities in the endocrine system, abnormalities in the hair cycle, autonomic nervous disorders, nutritional disorders, and other causes caused by hereditary or aging. Further, as a conventional hair growth and hair growth component, for example, linoleic acid monoglyceride (JP-A-63-2011)
No. 14), estrogen (JP-A-60-38313)
Hormones, vitamins E, B2, B6, biotin, pantothenic acid, etc., and other amino acids (peptide substances: JP-A-61-7209)
And existing peripheral blood circulation enhancers (vitamin E and its derivatives,
Assembly extract, garlic extract, ginseng extract, aloe extract, cepharanthin, carpronium chloride, minoxidil, etc.), topical stimulants (e.g., pepper tincture, vanylamide nonylate, ginger tincture, peppermint oil, benzyl nicotinate), anti-inflammatory agent (glycyrrhizinate) Licorice extract, diphenhydramine hydrochloride, etc.) are known.

[0005] Then, the above-mentioned hair growth and hair growth components are used alone or in combination with a plurality of hair growth and hair growth effects, and are used for hair growth and hair growth.
Many are aimed at comprehensive hair-growth and hair-growth effects such as promoting hair growth, preventing dandruff, Kayumi, inflammation, and preventing thinning and hair loss.

[0006]

SUMMARY OF THE INVENTION As described above, hair growth and scalp used for the purpose of growing or maintaining the hair of the scalp and skin.
Various components and techniques have been proposed for hair growth agents, and they are actually used at present. However, these hair restorers / hair restorers are not always effective enough and are not satisfactory in terms of safety such as causing skin irritation.

Therefore, attention has been paid to the effect of converting the rest period of the hair cycle into the growth period.
Attempts have been made to use the active ingredient as a hair tonic and hair restorer. In addition, the reason why the conversion effect from resting to anagen is used as hair growth and hair growth is that it is considered that in people with alopecia, the proportion of quiescent hair in the growth process of hair occupies the scalp / hair. Therefore, focusing on the hair cycle of hair, we have been studying and pursuing a hair nourishing and hair restoration agent that is effective in stimulating the quiescent roots and speeding up the transition to the anagen phase, and have been conducting intensive research. .

[0008]

In view of these circumstances, the inventors of the present invention have developed a useful plant having a hair-growing / hair-growing effect as a theme of development, and as a result, have developed button bog, bodaige, salvia, stevia, peonies, comfrey. , Bukuro,
It was confirmed that the plant extracts of Japanese gourd, Hypericum perforatum, Hange, Sakura and Perilla have hair-growth and hair-growth effects. or,
The present invention has been completed by providing a highly safe hair-growing / hair-growing agent free of scalp, hair, and skin without Kayumi, rough skin, and skin swelling.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS "Peony peony" used in the present invention means "Paeoniaceae", a plant of the genus Paeonia, and a button "Paeonia moutan Sims (=).
Paeonia suffruticosa Andrews) ".

[0010] "Bodaiju: Bodaiju" refers to Tiliaceae, Tilia platyphyllos Scop., A plant belonging to the genus Tilia, and Tyudaidai (Til).
ia cordata Mill.), Tilia europaea
L.) or other closely related flowers, fruits, bark.

"Salvia" refers to Labiatae,
Salvia officinal, a plant of the genus Salvia
is L.) Flowers, leaves, whole plants of "alias: sage".

"Stevia" refers to asteraceae (Composita
e) Stevia plant of the genus Stevia (Stevia re)
baudiana Bertoni) leaves and branches. In addition, what contains a steviol glycoside (stevioside) is preferable.

"Peony: peony" refers to the button family (Pa
eoniaceae), a plant of the genus Paeonia, a peony "Paeonia lactiflora Pallas (= Paeonia albiflora P
allas) or other related plant roots.

"Comfrey" refers to the family Boragi (Boragi)
naceae), leaves of a plant comfrey (Symphytum officinale Linne) of the genus Symphytum.

"Bukuryo: Bukuryo" is a sclerotium of a plant of the genus Polyporaceae (Polyporaceae) and Poria cocos Wolf (Poria cocos Wolf), with almost all exceptional layers removed.

"Ogon: Yellow Gon" is a Labiatae (Labi
atae), a root of the plant Scutellaria baicalensis Geoegi of the genus Scutellaria excluding the pericytes.

"Hypericum perforatum" is a plant of the family Hypericum (Guttiferae), a plant of the genus Hypericum (Hypericum) (Hypericum erectum Thunb.), Hypericum perforatum (Hypericum perforatum L.), and Scotch perforum var.
iom DC) whole grass.

"Hange: midsummer" means Araceae (Arac
eae), the plant of the genus Pinellia (Pinellia)
Inellia ternata Breitenbach) root mass without cork layer.

"Sakura: cherry blossoms" means Roacea
e), genus Prunus, subgenus sakura (Subgen. Cerasu)
s) Plants Oshima cherry (Prunus speciosa), Yamazakura (Prunus jamasakura), Oyama cherry (Prunus)
sargentii), edohigan (Prunus spachiana), mamezakura (Prunus incisa), Miyazaki cherry (Prunus maxi)
mowiczii), Yoshino cherry tree (Prunus yedoensis), Takanezakura (Prunus nipponica), Kasumizakura (Prunus)
leveilleana), Chow Ziza (Prunus apetala),
Kohigan (Prunus subhirtella), Satzakura (Prunus)
lannesiana), leaves of cherry such as Prunus kanzakura.

"Perilla: Shiso" is a Labiatae (Labiata)
e) Perilla plant (Perilla frutesce)
ns Britton var. acuta Kudo) or other closely related plants (La
biatae) leaves and branches.

[0021]

BEST MODE FOR CARRYING OUT THE INVENTION The extracts of bogpi, bodhidge, salvia, stevia, peonies, comfrey, bukuro, ogon, hypericum persica, hange, cherry and perilla used in the present invention are various parts of each plant ( Whole grass, flowers, fruits, leaves, branches, bark, root bark, rhizomes, roots, sclerotia, etc.) or as-crushed and then squeezed. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and diethyl alcohol. Esters such as ether, dioxane, acetonitrile and ethyl acetate, and organic solvents such as xylene, benzene and chloroform can be used alone or in any combination of two or more. It can be used even when the objects are combined.

In addition, various plant extracts such as bogpi, bodaiju, salvia, stevia, peonies, comfrey, bougainvillea, gougon, hypericum, hanger, sakura and perilla are dried according to the dosage form and form of the applied hair restorer / hair restorer.
Concentration or dilution may be arbitrarily performed and adjusted.

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature to normal pressure. After extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added to the extent that the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The buttonpi, bodaiju, salvia, stevia, peonies, comfrey, bukuro,
Various plant extracts such as Ogon, Hypericum perforatum, Hange, Sakura, and Perilla can be blended into hair growth and hair growth agents, but the amount is not specified, but the type, quality and expected of hair growth and hair growth agents are expected. Although it varies slightly depending on the degree of action, it is usually 1% by weight or more (hereinafter, expressed as% by weight), preferably 20 to 100%. If the amount is less than 1%, the effect cannot be expected sufficiently.

The hair-growing / hair-growing agent of the present invention can be used in addition to the above-mentioned essential components, if necessary, in the preparation of pharmaceuticals, quasi-drugs, cosmetics, etc. within a range not to impair the effects of the present invention. It can be produced by arbitrarily selecting and using the components and additives used.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil,
Cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukuinut oil, safflower oil, shea butter oil, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil , Mink oil, egg yolk oil, cocoa butter, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, hydrogenated products of these oils (hardened oil, etc.) and the like.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax, squalene, squalane, pristane, and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid , 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2
-Synthetic fatty acids such as ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, saccharides and water-soluble polymer compounds Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose and its esters, trehalose and its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or hydroxyalkyl (C2-C4) to which alkylene (C2-C4) oxide such as ethylene oxide is added. ) Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid and its salts, hyaluronic acid and its salts, chondroitin sulfate and its salts, heparin, ethyl cellulose, methyl cellulose, carboxy Methylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol Alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylic acid salts, polyalkylene oxide or crosslinked polymer thereof such as polyethylene oxide or polypropylene oxide, carboxyvinyl polymers, such as polyethyleneimine.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactant, surfactant containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: ascorbic acid and its derivatives, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D)
3), dihydrotaxerol, vitamin E group: tocopherol and its derivatives, ubiquinones, vitamin K
Group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (Rutin, eriocitrin, hesperidin), vitamin U, etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a usual manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later. However, usually, water and a water-soluble organic solvent (for example, ethanol) are used. ,Propylene glycol,
1, selected from 1,3-butylene glycol)
It is desirable to use a species or a mixture of two or more species. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

It should be noted that additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as flavoring, deodorizing, thickening, preserving, and buffering can be expected.

As a specific plant (crude) used as a raw material,
For example, almond (Hen peach), eye (Aiba), blue oak
(Seifu Wisteria), Aotsujirafuji (Kibo), Aono Ryukyuran, Fukurin Ryuetsuran, Acacia, Akasugi Fruit, Akavine, Akamegashiwa (Red Bud), Akane (Akane Grassroot), Akayajiou Jio (Jihuang), Agi (Awei), Akinire (Royu bark), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Toshibushi), Ashitaba (Asuka), Azuki (Red azuki), Acerola, Asenyaku (Asenyaku), Anise, Abemaki fruit , Avocado, flax, amateur (sweet tea),
Amachaworu, Amadokoro (Jade bamboo), Amigasa lily (Shellfish), Altea, Arnica, Aloe (lux), Aloe vera, Angelica, Anzu Honganzu (Anjin), Ansokkou (Azuka), Ikakozolina (Biliary head), Itadori
(Tiger cane root), strawberry, fig (fructose) or its leaves, strawberry (winter aoiko), ichiyakuso, ginkgo (ginko leaf, ginkgo),
Itohimehagi (Enshi), carob, rice seed or seed coat,
Inondo seeds, Ibuki-kusou-so, nettle, ylang-ylang, fennel (Fenka), ukiyagara (sanryou), gull-kasukagra fruit, Hime-uikyo, turmeric (Utsukin), Usubasaishin-keirinsaishin (spicy), Usveniaoi,
Usenitachioi, Echinacea purpurea (summer hay), Udo or Shishiudo (Qang, Independent, Tang Independent), Ume (Umei) or its flesh, Vladigashi, Oolong tea, Uwaurushi, Unshurikan (Chen skin), Estragon, Ezocogi (Yezo five) , Ezoki strawberry, Echinashi (Echinacea purpurea), Enoki, Ebisugusa (Keiko), Elderberry fruit, Elemi, Enju (Gossip flower, Sophora edulis), Ogi / Kibaanagi (Associated rice), Ouren (Yoren), Okarasuuri (Karonin) ), Ootsuji Lafzi (self-defense), Psyllium (vegetative child, vegetative grass), Toucan hazel (Haruko), Obanana okera okera
(White ajutsu), fruit of the sedge beetle, hawthorn hawthorn, hawthorn (Yamatoko), snowy squirrel, snowy squirrel, barley (barley), ogurma (turning over), okra fruit, panax ginseng and tochibanzin (carrot), swordfish (continuous) Ears), Onigurumi, Oninoyagara (Tianma), Onyuri Sasasayuri Hakatayuri (Yuri), Ononis, Halibut (Hashiha Yu), Ominaeshi (Loose), Dutch Strawberry, Dutch Karashi (Cresson), Dutch Jelly, Dutch Mitsuba, Olive, oregano, orange fruit or pericarp, calyxio (ripe yellow), cacao seeds, oysters or leaves (persimmon), kagi kazura (chotou hook), cassia, kasinaki fruit (kotsumi), gajutsu (shajiatsu), kashiwa (Kazuki, Sakura), Cascarilla, Kanixa (Kinosato), Valeriana (Kikusone), Birch or Weeping birch (White birch), Pumpkin, Ka Poknut tree seeds, Kahokoku-sansho (shopper), Gama (Kamaoh), Chamomile ・
Roman chamomile, Kamiyatsude (weed plant), crow squirrel (flower meadow), oak wheat, guarana seed, karaya, karin (mouse gourd), garcinia, kawayanagi, kawatake mushroom, kawamoyomogi (inchinko), kansui (sweet), licorice (licorice), Kantala Asa, Candelilla, Canto, Canna, Raspberry, Kiwi Fruit, Kikarasuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum), Kisage (Azusa), Gigi
(Yotei root), Pheasant (Kikomi), Kizuta, Kidachi aloe, Kidachi mint, Kina, Kinoki (Shincona, Akakinoki), Yellowfin (Huangbashi), Gymnema sylvesta, Cabbage, Cabbage immature, Cucumber, Kiraja saponaria, Kiraya, Kumquat fruit , Betel, golden hibiscus (Sesame crane), guava fruit, guayule, Quercus infectria (gallicate), kukui nuts, wolfberry (Gugi, gugiko, gugi leaf, skeletal bark), Kusugi Kazura (Tenmen winter), Kudzu
(Kakkon), camphor tree, gooseberry fruit, gardenia (garden garden), kunugi (bokusou), kumazasa, black pine tree (mawhisher), clara (bitan), cranberry fruit, chestnut or its astringent skin, curculigo latifolia fruit, grapefruit, Buckthorn, black crab, rescue, clove
(Crotch, Choka), Kaigai (Echigo, Ikugoho), Keito (Rooster, Chicory), Gekkeiju (laurel), Kenashisarutoribara (Tokubukuryo, mountain return), Gentiana, Gennoshoko (Oldbrow grass), Koshinbara (Monthly) Flower), crow mint, kouzo fruit, kocha (tea), kohone (river bone), kouhon (straw and kara straw), kouriang, cilantro fruit,
Cowberry (Koshibachi), Coconut fruit, Goshuyu (Gusyuyu), Goshoyutigo (covered bunko), Pepper (pepper), Copaiba balsam, Coffee beans, Kobushi magnolia (Spicy), Burdock (burdock, burdock), Kobotur, sesame (Sesame), sesame seeds (Gensan), garnish (Gomiko), Sanekazura, Binankazura, Matsubusa, wheat (wheat), rice, rice bran (red bran, white bran)
Rice oil, cola acuminata seeds, cola vera seeds,
Fenugreek fruit, colombo, kondurango, konjac, sisal, sisal asa, saximabotdul,
Cherries, pomegranates, sasa, sasanqua, sagiomodaka
(Sawaka), sweet potato, sugar cane, sugar beet, sapling jujube (acid jujube), saffron (safflower, west safflower), pomelo fruit, sabonso, salmonberry fruit, sarashinasho (masuma), sawagikyo (yamakonasai), sawagurumi ( Wild walnut), Panax ginseng (37 ginseng), Sanshuyu
(Susyuyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyanoki fruit, Shiitake (Shiitake), Shion
(Shien), red squirrel, red beetle (mikomiko), rosewood, linden, Chinese forsythia (forsythia), sycamore (chrysanthemum flower), sycamore, potato, shajin (shasan), janohige
(Bakumon Winter), Juzudama, Palm Fruit, Ginger (Ginger),
Shobu (irises, iris roots), shrimp fruits, birch seeds, white butterfly butterflies, white bananas, white banana flowers, white minant (Nantami), cinchona cassula bra, cinnamon, watermelon (watermelon), honeysuckle (gold and silver flowers,
Shinobi winter), sorrel (acid model), swimberry fruit, strawberry fruit, horsetail (thorn), plum fruit, Scots pine cone, pine larch, Scots vine, Scots walnut, Scots hawthorn, Scots dandelion, Scots cypress (Maloney), Pear fruit, snowy pear, European elderberry, elder tree (juniper and juniper), yarrow (milfoil), balsam pear, balsam pear, mistletoe, smelt, and swordfish Root), mallow, hirohasenega, senega, seri, celery, senkyu (river cucumber), sendan, senburi (drug), senna fruit or leaf, senninsou (large tate), souka (grass), buckwheat seeds, soybean imo, rhubarb (Big ), Radish, soy, orange (orange peel, Fructus Aurantii Immaturus), Euphorbia pekinensis (Dai戟), Takawarabi
(Gull), dark sweet cherry fruit, hollyhock, hollyhock (thyme, Hyakuka), hollyhock (tachibana skin), hollyhock willow, tamarind seeds, onion, tamashiba (spicy), arachis or its root bark, tanjin (dansan), dandelion (Gakukohide) or white dandelion and moko dandelion, dammar, cherry fruit, chigaya or its root (chinese), chikusetsu carrot (bamboo ginseng), chicory, ginseng
(Gomiko), Korean Radish (Ohio), Korean Elm
(Wuyi), Ginseng (Ginseng), Artemisia
(Aiba), Choreimaitake (Irei), Tsukimiso, Tsukuritake (mushroom), Camellia, Camellia, Clover
(Lacquer mother grass), asiatica (duckling primrose), vine adzuki (red azuki bean), tsuldokudami (what a crow), tsuruna (apricot apricot), truss ginseng (four-leaf ginseng), tsuwabuki, daico, teuchigurumi, duberry fruit, daidaiyaku (crow medicine), Pepper (winter melon), pepper (bancho), touki (toki), calendula (marigold), corn or corn hair (nanban hair),
Horned moth (woman Sadako), tourindo (ryu-bili), dokudami (jujutsu), radish (tomato), toshishi, medadaoshi, and shinashikazura, eucommia (tonaka, tonakaha), tomato, tragacanth, triacanthos seed, tormentilla, dronoki, Troroaoi, Niseria berry fruit, Yam yam (Yakuyaku), Nagikadida (Butcher Bloom), Naginata Koju, Nazuna, Rape, Natsumikan, Jujube (daijutsu), Naniwaiba (Kinzakurako), Nameko, Narco lily (Yellow), Peanut (Peanut), Nanten (Minami Tenmi), Nigaki (Maki), Shrimp Mug (Agai), Nikuzuku (Nutmeg),
Kay Nikkei (Kihi bark), Keishi (Keishi), Chinese chive (Nirako),
Fruits, flowers or foliage of elderberry (bone-attached tree), garlic (garlic), nurde (fivefold), green onion, thistle (daiji), wild rose (fruit), saw millet, nodake (maehu), nobara, peach, palm, pineapple Fruit, Hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (Bone Crushing), Hakusen (Rinosaur), Huckleberry Fruit, Hakbe (Regular), Hazel (Haruko), Hashiridoro (Rot Root), Basil, Lotus (Lotus Meat) , Rensui), parsley (Netherlands jelly), naked mussels, batata, hachiku madake (bamboo-boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuninin), hanasuge (chimochimo), banana, hana mint, vanilla bins, papaya , Hawk grass (rat malt grass), hub grass, paprika, hamagou / mitsubahamagou (vine thorn), hamasuge (kosuke), hamabishi (situriko), hamanas (maikai flower) ,
Hamabofu (beach storm), Hamamelis, Rose (rose), Parietaria, Harunire (Yellow, Yuhakuh, Yuba), Breadfruit,
Hiogi (sun dried), lizard carrot (party), pecan nuts, gangamana (stone and vines), cypress (extended life grass), cypress (hishomi), pistachio, beet, hitotsuba (stone reed), hinotakokochi ( Beef knees), hinoki, hiba, castor, sunflower, bell pepper, hymegama (incense crab), himematsutake (kawariharatake, hiromatsutake), pimenta fruit,
Juniper, juniper, hyouju fruit, below mallow,
Hiroha okinagusa (Hakuto Okina), loquat (loquat, loquat leaf), betel nut (large clothing, arelocha), sprout kazura (southern rattan), butterbur,
Coltsfoot (winter flower, winter leaf), fujibakama (orchid grass), wisteria bean (flat beans), grape fruit or pericarp, seeds, leaves, beech,
Fumushinashikutaketake (Cordyceps), Brazilian Licorice,
Black currant fruit, blackberry, plum fruit, furcellaria, blueberry (Prunus aegypti), prunes, blond psyllium, bundou (green beans), loofah, safflower (safflower), henneken, belladonna, berry fruit, Perbianberg, Boysenberry fruit , Bofu (windbreak), spinach, physalis (Torone), honoki (thick, Japanese thick), bokeh (mochi), hosovanaokera (sojutsu), hosobabarengiku, hops, jojoba, whiteberry fruits, honshimeji, misuzutennan Shaw (Tiannan star), Ephedra (mao), Macadamia nut, Macri (seaweed), Magwa (mulberry white skin, mulberry leaf), Matabi (mokuten tate), Matsukasa, Matsuba, Mayorum (Hanahakka), Malvanozadin , Mulberry fruit, quince, mango, mangosteen, mansugurumi, mandarin Real, Ganoderma lucidum (Reishi), Citrus plant fruit (Fructus Aurantii Immaturus), Bupleurum (Saiko), Lobelia chinensis (Hanhenhasu), Misohagi (Misohagi), Menyanthes trifoliata, Mitsuba, spearmint, mimosa,
Ginger, miracle fruit fruits, myrrh, myrobaran, mugwort (woody geese), mukunoki, mukuroji, murasaki (purple root), murasaki maize, mehajiki (benefit mother grass), mebogi, melaleuca, melissa, melilot, melon fruit, makoyoko tree, moso-kook Incense), Maple blossoms, Peach leaves (peach leaves), fruits and seeds (peach seeds), bean sprouts, morello cherry fruits, moloheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflowers (cornflowers), cornflowers , Yashabushi (arrow wheel), willow willow, yatsude (octagonal gilded), mistletoe (parasitic willow), willow leaf, yabugarashi, yabukouji (purple gold beef), pokeweed
(Land), alder (Yamaharu), bayberry (Yumebai), mugwort, eucalyptus, yukinoshita (tiger eargrass), yucca flebifolia, yuzu fruit, lily, yorigusa, (European strawberry), mugwort (Aiba), lime Fruits, rye, Lacanca fruits, raspberry leaves and fruits, lavender,
Longan (longan meat), ryocha (green tea), apple fruit,
Gentian, Lubas suavisimus (sweet), lettuce, red currant fruit, lemon fruit, lemongrass, forsythia, forsythia, coconut, loganberry fruit, logwood, rosemary (mannen wax), rosehip (nobara) , Wasabi, Waremokou (Jiyu) and so on.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaonori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombu algae: brown alga; , Resiliconibu, hosomekobu, mishitishibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red algae: hijirimen, maxa ( Tengsa),
Hirakusa, Onyxa, Obakusa, Kataobaxa, Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Byaksinkirinsai, Tsunomata, Obatsunomata, Tochaka, Tohkanota, Tojika , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohigewari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asamidori ogusa, kawashiogusa, marimo, valonia: tamagobaronia, tamabaronia, magnum: tamatamamo, iwata: husaiwata, suricogita, heraiwirata, crocodile, crocus Sakibutimimil, Nagamil, Hiramil, and Casanori:
Casa nori, Juzumo
Mizojuzumo, Mizuazumimo, Korekaete, Tsutsumimo, Kikkogusa: Kikkogusa, Hitoexa: Hitoexa, Hirohanohiegusa, Usuhitoexa, Motsuhitoe, Sayamidro, Genus spp.

Blue-green algae (Genus L .: L., L., L., L .: L., mushrooms,
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiacacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp.
Genus Isogawara, genus Isogasula, genus genus: Gunsenkurogashira, genus Kashirazaki, genus Kashirazaki, genus Muchimo: genus Muchimo, Hiramutimo, Kebelligsa, genus Amis. Artemisia spp.
Genus Matsumo: genus Matsumo, genus matsumo: genus sylvestris, genus okinawa, genus okinawa-mozuku, genus niseftomozuku: niseftomozuku, futomozuku: genus futomozuku, ishimozuku: ishimozuku, kuromo: kuromo, nisemozuku: genus, spruce, spruce Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Species of the genus Coleoptera, Tobacco planta, Laminaria genus: Laminaria genus: Habanomodo genus: Habanomodo genus, Habanori genus: Havanori, genus Habanori: genus Habanori, genus bukuro: common bukuro, Ezobukuro genus: Ezobukuro, Fukuronori genus: Fukuronori, Watanabe Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Turrum, Genus Anana: Genus Anastasia, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Genus Ligustrum, G. , Onikombu, Goheikombu, Nagakombu, Pea kelp, Ochimikombu, Torokombu genus: Torokombu, Antokume genus: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikomu: Genus Kikuishi, Nejirekomu: Neshilecomb, Kuroshiomeko : Nekoshikambu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yabanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Honamomaku, Tamamomaku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametawara, Tatsukuri, Yasumatamoku, Umitranoo, Oobamoku, Fushizushimoku, Hahakimokum, Togemoku, Jolemoku, Saw-mokum, Obanoki-moku, Genus genus: Genus
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Genus genus: Ushikenori, Funorinoushike), Genus Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: sodegarami, rattles: rattle, hiraragara, hirohatamataki: hirohatamatamadaki, tamamaidaki: tamaitadaki, kakenokenori: kaginori, kakenenori, tengusa, kurobana, kurobana, swordfish, swordfish, squirrel Genus: hibiroudo, himehibiroudo,
Genus genus: genus isensis, genus genus:
Genus spruce, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarequigusa: Nisekarequigusa, Okitsubara genus: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana: Genus Hosobanamino, Naminohanagosa, Coralthus Genus Ikawanokawa, Genus Kanokawa: Kinokawa, Genus Kaninote: Kaninote, Coralum: Coralum, Genus Mucadenori: Mucadenori, Sujimukade, Catanori, Hiramukade, Kyonohimo, Sakuranori, Nikunukade, Tambanori, Tsurutsuru,
Genus Isonohana: Nuracusa, Chronulaxa, Stinging genus, Hirakintoki Genus: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakureto: Genus Otokinari, Genus genus Genus Nagaobane, Genus Funori: Hanafunori, Fukuronori, Makhunori, Karenikusa Genus: Kalexigusa, Tosakamaki Genus: Hosobanotokamaki, Hirohanotosakamodoroki, Yatsudegatotoka, Kurotosakamodoki, Nezashinokidoka, Nezashinokinusakada Genus: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuhono Oh, the genus Venice: genus Venice, genus Suskabeni: genus Suskebeni, genus Okamuragusa:
Yamadagusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobaliso, Phyllophorus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizokonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge, genus: ssp.
Genus: crocodile, saimi, crocodile, crocus genus: genus genus: moss genus, genus cynosum: squid moss, hosoibonori, nobonori, kurohaginnansou genus: kurohaginnansou, akabaginnansou genus: akabaginnansou, genus genus: genus serrata The genus Thaliosa: The genus Thalassium, Hanasakura, The genus Scrophulari: The genus Scrophulari, Schikonori, The genus Hananoeda: Hanaeda, The genus Hirata: The genus Hirata goat, The genus Darus: The darth, Masagoshibari, Anadarus, The genus Webagusa, Benifukunori
Genus Fusinagi: Fussushinagi, Himefusushinagi, Hirohafushinagisagi, Satsumagiso Genus: Hirawaginagiso, Usubawaginagiso, Igis Genus: Igis, Keigisu, Harigigissu, Haneigisu, Amigusa, Egonomida, Chrysanthemum Genus, Genus genus Family: Habutaenori, Konohanori, Suzuronori, Usveni genus: Usbeni, Hasujiginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Sujiginu, Atubastinu, Hyasubanori: Kagiusubanori, Jaureusubanoli, Jareusubanoli
Genus Ayanishiki: Genus Ayanishiki, Genus Ayaginu: Genus Ayaginu, Genus Dadia: Enashidazia, Genus Shimadagia: Isohagi, Simadadia, Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moleutogusa, Genus Genus: Makuri, Yanaginori, Hanayana, Rana Salix var. Genus Isomegusa: Isomegusa, Suzinasugusa: Suzinasugusa, Isobashou Genus: Isobashou, Fujimatsumo Genus: Fujimatsumo, Sawtooth Lilium: Scutellaria Rihiba, genus: genus kawamozuku, okamomozuku, himekamozuku, genus idiomyme: ideyugomegome, genus okitamozuku: genus okitimozuku,
Genus genus, genus chinorimo: chinorimo, genus genus: chisinori).

The axles of the axle (Charium spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flasksmo: Himefuramocha, Chaboflasmo, Tripera, etc., and yellow algae (Hikarimo: Hikarimo etc.).

Materials derived from animal raw materials include a cockscomb extract, a cow / human placenta extract, a pig / cattle stomach, a duodenum or an intestinal extract or a decomposition product thereof, and a pig / cattle spleen extract. Products or their degradation products, extracts of swine or bovine brain tissue, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolysates, elastin, elastin hydrolysates, water-soluble elastin derivatives, keratin and its decomposition products Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig / bovine blood cell protein degradation product (globin peptide), a pig / bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.), milk , Casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg ingredients Such as fish meat decomposition products.

(14) Microbial culture metabolites Yeast metabolites, yeast extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation of skim milk powder, trehalose or derivatives thereof.

(15) α-hydroxy acid Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorbing / blocking agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, benzophenones, oxybenzone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, urocanic acid derivatives, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin B6 derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine and the like.

(19) Tyrosinase activity inhibitor Ascorbic acid and its derivatives, hydroquinone and its glycosides, kojic acid and its derivatives, placenta extract, silk peptide, plant extract (mulberry, corn, waremoko,
Clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odorisium, hops, hawthorn, eucalyptus, achillea millefolium, artea, keihi, mankeishi, hamamelis, yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, sun dried, hemp yellow, (Sengyu, Dokkatsu, Psycho, Bohu, Hamabofu, Ogon, Peony, Peony, Genenoshoko, Kakkon, Licorice, Gopiko, Aloe, Shouma, Safflower, Green Tea, Tea, Asenyaku).

(20) Melanin dye reduction / decomposition Hydroquinone monobenzyl ether, phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide and the like.

(21) Acceleration of turnover / cell activation Hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract ( Aloe, ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odikoso, Assemble, Touki, Toukensenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley, etc.).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavengers SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants ascorbic acid and its salts, stearic acid esters, tocopherol and its ester derivatives, nordihydroguaseletenic acid, butylhydroxytoluene (BHT),
Butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeiso, Birch, Sage, Rosemary, Minami Minami,
Kina, age, ginkgo, green tea, etc.).

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d or dl-
Camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts and the like.

(27) Disinfectant / Disinfectant Acrinol, sulfur, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride, cresol, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid and its salts, polyethylene glycol, chondroitin sulfate and its salts, water-soluble chitin or chitosan derivatives, sodium lactate and the like.

(29) Agents for hair Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(30) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(31) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-
Amino-4-methylaminoanthraquinone, 3,3'-
Iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, meta-hydrochloride Phenylenediamine, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene
3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, piclamic acid, sodium piclamate,
N, 'N-bis (4-aminophenyl) -2,5-diamino-1, -4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaamino Phenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate,
2,4-diaminophenol sulfate, toluene-2 sulfate,
5-diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol , Diphenylamine, α
-Naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzozen-5'-sulfonate, hematein and the like.

(32) Flavor Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Great Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(33) Dyes and Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposition products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

The dosage form of the hair-growing / hair-growing agent of the present invention is arbitrary, and may be capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, It can be used by blending it in sheet-like pharmaceuticals, quasi-drugs, and cosmetics for skin and hair.

Specifically, for example, external preparations, cosmetics such as creams, lotions and oils, shampoos,
Hair cosmetics such as rinses, hair treatments, hair creams, pomades, hair sprays, hair styling products, perm agents, hair tonics, hair dyes, hair growth and hair restoration, etc.
Use for general foods and drinks is also possible.

The method of adding the various plant extracts of the present invention to a hair growth and hair growth agent may be added in advance or during the production, and may be appropriately selected in consideration of workability. Good.

[0074]

EXAMPLES The present invention will now be described with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Production Example 1) Button bodice, bodaige, salvia, stevia, peonies, comfrey, bukuro, ogun, hypericum, hange, cherry, perilla,
100 g of each was warmed and extracted with purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dry solid content: about 0.1 to 3.0% by weight).
About 1.0 kg.

(Production Example 2) Button bodice, bodaige, salvia, stevia, peonies, comfrey, bukuro, ogun, hypericum, hanger, cherry, perilla,
100 g of each was immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid content: approx.
1.0-3.0% by weight).

(Production Example 3) Pomegranate, bodaige, salvia, stevia, peonies, comfrey, bukuro, ogon, hypericum, hanger, cherry, perilla,
100 g of each was immersed in 70% ethanol solution, 30% 1,3-butylene glycol solution, or 60% propylene glycol solution, or purified water (about 30 ° C), extracted at room temperature for 5 days and nights, and then extracted by filtration. About 1.0 kg of a liquid (dry solid content: about 0.1 to 3.0% by weight) is obtained.

(Test 1) Hair growth promotion test of C3H mouse Approximately 8 cm ² of the back of the animal was shaved with an electric clipper and an electric shaver. Next, place the sample on the depilated back once a day, 5 days a week for 2 days.
Application was performed for 0 days. On the 12th and 20th days after application, the area ratio (%) at which hair regeneration was observed relative to the area from which the hair had been removed was measured with an image analyzer, and compared with the control group.
The results are shown in FIG. "Ogawa et al.'S test method (Refer to Flexural Journal, Vol. 17, No. 5, P. 20-29 (1989)")

(Test Method) a. Samples The various plant extracts obtained in Production Example 2 of the present invention were used as undiluted solutions. As a control, only a 30% aqueous ethanol solution of the base was used. As a positive control, a solution prepared by dissolving minoxidil in a 30% aqueous ethanol solution at 0.5% (w / v) was used. b. Experimental animals 8-week-old male C3H mice were used. These animals were bred in an environment of room temperature 22 ± 2 ° C., humidity 50 ± 15%, all-fresh ventilation 15 times / hour, and lighting 9 hours / day. Animals had free access to solid feed MF (Oriental Yeast Industry) and tap water.

[0080]

FIG.

(Test Results) As shown in FIG. 1, the buttonpi, salvia, ogon, stevia, hypericum,
In the plant extract of hange, hair regeneration was significantly increased, and hair regeneration almost equivalent to that of minoxidil was observed. Also, the comfrey, peonies,
Plant extracts of perilla, bukuro, cherry and bodaille also showed significant hair regeneration compared to the control, although weak.

(Test 2) Safety test (1) Primary skin irritation test The various plant extracts obtained in Production Examples 1 to 3 were added to purified water so that the dry solid concentration was about 0.5 W / V%. White rabbits (Female, 3 per group, weight 2.3k)
g) of the skin. The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 3) Safety test (2) Skin cumulative irritation test Similarly, various plant extracts obtained in Production Examples 1 to 3 were purified so that the dry solids concentration became about 0.5 W / V%. Hartley guinea pigs prepared with water and shaved on the flank (female,
Once a day, 5 times a week on the skin of 3 animals per group, weight around 320g)
0.5 ml / animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day of each application and on the day after the last application using the primary irritancy scoring method using erythema and edema as indexes. As a result, all animals were judged as negative without any erythema and edema over 2 weeks.

(Test 4) Safety test (3) Acute toxicity test Similarly, powders obtained by concentrating and drying the various plant extracts obtained in Production Examples 1 to 3 (dry solid content: about 1.0 W / V
%) Was orally administered to ddy mice (male and female, 5 mice / group, 5 weeks old) in a 2,000 mg / kg dose fasted for 4 hours before the test, and the appearance and extent of toxic symptoms were observed over time. did. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore, LD50
Was determined to be 2,000 mg / kg or more.

(Formulation example) Production of hair growth and hair growth agent According to the above evaluation results, the formulation examples are shown below, and each formulation example may be one manufactured by a usual method in the manufacture of each product. showed that. Further, the present invention is not limited to these.

(Formulation Example 1) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: 50% ethanol extract of buttonpi B: 50% ethanol of bodaige Extract C: Salvia 50% ethanol extract D: Stevia 50% ethanol extract E: Peony 50% ethanol extract F: Comfrey 50% ethanol extract G: Bulky 50% ethanol extract H: Ogon 50% ethanol extract Liquid I: St. John's wort 50% ethanol extract J: Hange 50% ethanol extract K: Sakura 50% ethanol extract L: Perilla 50% ethanol extract * Any one of AL extract 25.0 5. Preservative Appropriate amount 6.Remaining amount of purified water 100

(Formulation Example 2) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6.Egg extract 50% ethanol extract 10.0 7.Comfrey 50% ethanol extract 10.0 8.Sakura 50% ethanol extract 10.0 9.Perfume, preservatives appropriate amount 10.Purified water 100 residue

(Formulation Example 3) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Stevia extract 10.0 (Ethanol: 1,3- (Phenylene glycol = 1: 1 extract) 6. Peony 50% 1,3-butylene glycol extract 5.0 7. Hypericum 50% 1,3-butylene glycol extract extract 10.0 8. pH adjuster qs 9. Preservative qs 10 .Remaining amount of purified water 100

(Formulation Example 4) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Comfrey 30% ethanol extract 8.0 6 .Hange 50% propylene glycol extract 7.0 7. Preservatives appropriate amount 8. Purified water 100 residue

(Formulation Example 5) Lotion% by weight 1. Sorvitol 2.0 2.1.3-butylene glycol 2.0 3. Polyethylene glycol 1000 1.0 4. Polyoxyethylene oleyl ether (25E.O.) 2.0 5. Ethanol 10.0 6. Bodige 50 % Ethanol extract 5.0 7. Ogon 50% ethanol extract 5.0 8. Sakura 70% phthylene glycol extract 5.0 9. pH adjuster qs 10. Preservative qs 11. Purified water 100

(Test 5) Use Effect Test The effect of the hair growth / hair restoration agent of the present invention actually used was examined. The test used was a panel of 10 people (25-50 years old) complaining of alopecia and alopecia, and twice daily in the morning and night (after washing the hair at night) twice a day. The usage test was performed by applying an appropriate amount to the scalp for 3 months and 6 months. A control prepared by removing the various plant extracts of the present invention from the hair tonic in the same manner was used as a control.
The evaluation was performed according to the following criteria. The results are as shown in Table 1 and the numerical values in the table represent the number of persons. No one complained of scalp abnormalities during the use period.

"Effect of improving skin (scalp) disease" Efficacy: Very many downy hairs were generated. Slightly effective: slight downy hair was generated. Ineffective: No change from before use.

[0093]

[Table 1]

(Test Results) As shown in Table 1, the buttonpigs, bodaijus, salvia, stevia, peonies,
Comfrey, bukuro, ogon, Hypericum perforatum, hange, cherry, and perilla extract all had a slight difference, but the number of people who had naive hair increased, and hair growth and hair growth effects were observed.

[0095]

EFFECTS OF THE INVENTION Buttonpigs, bodaiges, salvia, stevia, peonies, comfrey, bukuro,
A hair restorer / hair restorer containing one or more plant extracts of Hagone, Hypericum perforatum, Hange, Sakura, Perilla has excellent hair growth / hair restorer effects and is safe for humans or animals. It is. In addition, it can be used for general foods and drinks.

[Brief description of the drawings]

BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a diagram showing the regenerated hair area ratio of various plant extracts of button bog, bodige, salvia, stevia, peonies, comfrey, bukuro, ogon, hypericum, hanger, cherry and perilla of the present invention.

Claims (1)

[Claims] (1) Botanpi, bodaiju, salvia, stevia, peonies, comfrey, bukuro, ogon,
A hair restorer / hair restorer comprising at least one plant extract selected from Hypericum, Hange, Sakura and Perilla. [0001]