JP2000344632A - Hair grower containing plant extract - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new and safe hair grower from a planet. SOLUTION: This hair grower comprises the extract of Lindera strychnifolia (Sieb. et Zucc.) F.Vill. [=Benzoin strychnifolium (Sieb. et Zucc.) O.Kuntze] or the combination of the extract of Lindera strychnifolia (Sieb. et Zucc.) F.Vill. [=Benzoin strychnifolium (Sieb. et Zucc.) O.Kuntza] with the extract of the or more plants selected from Aloebarbadensis Mill. (=Aloe barbadensis Mill. (=Aloe Vera L.), Rabdosia faponicus (Burm. f.) Hara (=Isoden japonicus Hara) or Isodon trichocarpous Kubo, Scutellatia baicalensis Geogi, Panax ginseng C.A.Mey. (=Panax schinseng Nees), Hytpericum erectum thunb., Magnolia obocate Thunberg, Symphytum officinale Linne, Prunus speciosa, Salvia officinalis L., Perilla frutescens Britton car. acuta Kudo, Paeonia lactiflora Pallas (=Paeonia albiflora Pallas), Stevia rebaudiana Bertoni, Ophelia japonia (Schult.) Griseb. (=Gentiana japonica Schult.) (= Swertia japonica (Schult.), Pinellia ternata Breitenbach, Belamcanda chinensis(L.) De., Poria cocos Wolf, Tilia platyphyllos Scop., and Paeonia moutan Sims (=Paeonia suffruticosa Andrews). The hair grower has a excellent hair-growing effect, gives good gloss, tension and lubricity to hair, improves the combinanility of the hair, and is safe for persons and animals. The extracts may also be used for other general foods and drinks.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a Japanese yak extract or a Japanese yak extract, which includes aloe vera, Japanese radish, Japanese gourd, Panax ginseng, Hypericum perforatum, Koboku, Comfrey, Sakura, Salvia, Perilla, Peony, Stevia, Sembi, Hange, The present invention relates to a novel and safe hair tonic and hair restorer in which the regeneration of hair is significantly recognized by using one or more plant extracts selected from a green onion, a liquorice, a borage, and a pigeon.

[0002] The field of application is, for example, applicable to all kinds of external preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids, 1) Pharmaceuticals, 2) of liquid, gel or air bubbles
Quasi-drugs, 3) topical or systemic skin cosmetics,
4) Pharmaceutical or / and cosmetic preparations applied to the scalp / hair (for example, shampoos, rinses, treatments, permanent solutions, hair dyes, hair styling agents, hair tonics, hair growth / hair restorations, etc.) Can be

[0003]

2. Description of the Related Art Hair greatly affects the appearance and occupies a very important position in beauty. Alopecia is still a matter of deep concern, with no precise cure. There are two types of alopecia, congenital and acquired. There are many studies on the causes and mechanisms of alopecia, but there are many unclear points. Currently, many are on the market.

At present, the causes of hair loss are considered to be due to abnormalities in the endocrine system, abnormalities in the hair cycle, autonomic nervous disorders, nutritional disorders, and other causes caused by hereditary or aging. Further, as a conventional hair growth and hair growth component, for example, linoleic acid monoglyceride (JP-A-63-20163)
114), estrogen (JP-A-60-38313)
), Vitamins such as vitamin E, B2, B6, biotin, pantothenic acid, and other amino acids (peptide substances: Japanese Patent Application Laid-Open No. 61-7209).
No.) and existing peripheral blood circulation promoters (vitamin E and its derivatives, garlic extract, cepharanthin, carpronium chloride, minoxidil, etc.), local stimulants (capsicum tincture, nonylate vanilamide, ginger tincture, peppermint oil, benzyl nicotinate, etc.) ), Anti-inflammatory (glycyrrhizic acid, licorice extract, diphenhydramine hydrochloride, etc.)
It has been known.

[0005] Then, the above-mentioned hair growth and hair growth components are used alone or in combination with a plurality of hair growth and hair growth effects, and are used for hair growth and hair growth.
Many are aimed at comprehensive hair-growth and hair-growth effects such as promoting hair growth, preventing dandruff, Kayumi, inflammation, and preventing thinning and hair loss.

[0006]

SUMMARY OF THE INVENTION As described above, hair growth and scalp used for the purpose of growing or maintaining the hair of the scalp and skin.
Various components and techniques have been proposed for hair growth agents, and they are actually used at present. However, these hair restorers / hair restorers are not always effective enough and are not satisfactory in terms of safety such as causing skin irritation.

Therefore, attention has been paid to the effect of converting the rest period of the hair cycle into the growth period.
Attempts have been made to use the active ingredient as a hair tonic and hair restorer. In addition, the reason why the conversion effect from resting to anagen is used as hair growth and hair growth is that it is considered that in people with alopecia, the proportion of quiescent hair in the growth process of hair occupies the scalp / hair. Therefore, focusing on the hair cycle of hair, we have been studying and pursuing a hair nourishing and hair restoration agent that is effective in stimulating the quiescent roots and speeding up the transition to the anagen phase, and have been conducting intensive research. .

[0008]

In view of these circumstances, the inventors of the present invention have developed a useful plant having a hair-growing / hair-growing effect as a theme of development. Combined use of one or more plant extracts selected from the group consisting of Emisoso, Ogon, Panax ginseng, Hypericum perforatum, Koboku, Comfrey, Sakura, Salvia, Perilla, Peony, Stevia, Stevia, Hungary, Hiougi, Bakuryo, Bodaiju, Pontopi Was significantly recognized, and it was confirmed that it had a hair-growth / hair-growth effect. Also, for hair, gloss, tension,
The present invention has been completed by providing a highly safe hair-growth / hair-growth agent that gives smoothness and improves combability.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION "Yaku:
"Crowd, Tendai crow" means plants of the family Camphor (Lauraceae) and the genus Lindera (Lindera): Tendai yak "Lindera str
ychnifolia (Sieb.et Zucc.) F.Vill. (= Benzoin strychni
folium (Sieb.et Zucc.) O.Kuntze) ".

"Aloe vera" is a lily family (Liliace).
ae) Aloe plant (Aloe barbadensi)
s Mill. (= Aloe Vera L.) and its variants (Aloe Vera L.va
r.chinensis (Haw.) Berger), (Aloe saponaria Haw.), but those obtained from the leaves or stems are used.Others, congener species of Kidachi aloe (Aloe arborescens Mill.), Socotra aloe (Aloe perryi Baker), Natal Aloe baine
sii Th.Dyer), Aloe dichotohoma
L.), Aloe marlotii (Aloe marlothii Berger), Aloe pestris (Aloe rupestris Baker), Aloe spinosis (Aloe spinosissima Hort.), Aloe plicatilis (Aloe plicatilis Mill.), Aloe aeruperifolia (Aloe asperifolia A. Berger), Aloe captata Bak.var.cipolinicola
H.Perr.), Aloesplendens Lavra
nos), Aloe humilis Mill., Aloe mitriformis Mill., Aloe variegata L., Cape Aloe (Aloe f.
erox Mill.), Aloe africana Mil
l.), Aloe spicata Baker, (Aloe h
aworthiodes Baker), (Aloe succotrina Lam.,), etc.
Aloe leaves or stems can also be used.

[0011] "Emiso (Emisodium: life-prolonging grass)" refers to the Labiatae family (L
abiatae), Rabdosia japonicus (Burm.f.) Hara (= Isodon japoni)
cus Hara) ”or Isodon trichocar
pus Kubo) or whole plants.

"Ogon: Yellow Gon" means Labiatae (Labia
tae), a plant of the genus Scutellaria Scutellaria
(Scutellaria baicalensis Geoegi) without roots.

"Ginseng: Korean ginseng" is a plant ginseng of the genus Araliaceae and Panax L. "Panax ginseng CAMey. (= Panax
schinseng Nees) "" Alias: Panax ginseng ".

"Hypericum perforatum" refers to Hypericum family (G
uttiferae), Hypericum (Hypericum) plant Hypericum perforatum (Hypericum erectum Thunb.), St. John's wort (Hypericum perforatum L.), Hypericum perforatum L. var angustifoliom DC
Use whole grass.

"Kouboku: magnolia" means Magnolia (Mag)
nolaceac), Magnolia plant Magnolia
olia obovata Thunberg), Kalahoo (Magnolia officina)
lisRehder et Wilsons), Magnolia Sprengeli (Ma
gnolia sprengeri Pamp.) or the bark of a stem or branch of a related plant.

The term "comfrey" refers to the family Boragin
aceae), plant comfrey of the genus Symphytum
(Symphytum officinale Linne) leaves, branches and stems are used.

"Sakura: cherry blossom" refers to Roaceae,
Plants of the genus Prunus (Prunus), subgenus Sakura (Subgen.Cerasus), Prunus speciosa, Prunus yamazakura
jamasakura), Oyama cherry (Prunus sargentii), Edhigan (Prunus spachiana), Mamezakura (Prunus inci)
sa), Miyama cherry (Prunus maximowiczii), Somei Yoshino (Prunus yedoensis), Takane cherry (Prunus nipponic)
a), Kasumizakura (Prunus leveilleana), Chowzac cherry (Prunus apetala), Kohigan (Prunus subhirtella),
Satzakura (Prunus lannesiana), Kanzakura (Prunus k
azakura) or other leaves of cherry.

"Salvia" is a plant of the genus Labiatae and the genus Salvia (Salvia officinalis).
L.) "Alias: Sage" flowers, leaves and whole plants are used.

"Perilla: Shiso" refers to Labiatae,
Perilla plant (Perilla frutescens Britt)
on var. acuta Kudo) or other related plants.

“Peony: peony” is a family of Pae (Pae)
oniaceae), a plant of the genus Paeonia, a peony `` Pa
eonia lactiflora Pallas (= Paeonia albiflora Pallas
s) ”or other closely related plant roots.

"Stevia" refers to asteraceae (Compositae),
Stevia plant Stevia (Stevia rebaudiana)
Bertoni) leaves and branches are used.

The term "assembly: this drug" refers to the Gentian family (Gun
tianaceae), a plant assembly of the genus Ophelia (Ophelia)
elia japonica (Schult.) Griseb. (= Gentiana japonica
Schult.) (= Swertia japonica (Schult.) "

"Hange: midsummer" means Araceae (Arace)
ae), a plant of the genus Pinellia (Pinellia)
ia ternata Breitenbach).

"Hiogi: sun-dried" means "Irida"
ceae), a plant of the genus Hyuga (Belamcanda Adans.): Uses the rhizome of Hyalogi (Belamcanda chinensis (L.) De.).

"Bukuryo: Bukuryo" is a sclerotium of a plant of the genus Polyporaceae (Polyporaceae) and the genus Anato (Poria) of the genus Matsuri (Poria cocos Wolf), which is almost completely free of exceptional layers.

"Bodyju: Bodaiju" is a linden family
(Tiliaceae), a plant of the linden genus (Tilia)
(Tilia platyphyllos Scop.)
ordata Mill.), Tilia europaea
L.) or other closely related flowers, fruits and bark.

“Peony: Peony skin” is a family of Pae (Pae)
oniaceae), a plant belonging to the genus Paeonia, and the button `` Paeoni
a moutan Sims (= Paeonia suffruticosa Andrews) root bark is used.

[0028]

BEST MODE FOR CARRYING OUT THE INVENTION The yak, aloe vera, Japanese radish, Japanese gourd, Panax ginseng, Hypericum, Koboku, Comfrey, Sakura, Salvia,
Extracts of perilla, peonies, stevia, assembly, hange, rhododendron, rhododendron, botanical, bodaiju, and bogpi are the various parts of each plant (whole grass, above-ground, flower, fruit, leaf, branch, stem, stem, bark) , Rhizome, root bark, rhizome, tuber,
Roots, sclerotia, etc.) or crushed and squeezed. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent for the plant extract include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), and acetone. Ketones, ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene, chloroform can be used alone or in any combination of two or more kinds. It can also be used in a state where the extracts are combined.

[0030] In addition, eel, aloe vera,
Giant gourd, panax ginseng, hypericum, kouboku,
Various plant extracts such as Comfrey, Sakura, Salvia, Perilla, Peony, Peony, Stevia, Assemblage, Hange, Hiougi, Bakuryo, Bodaiju, Botanpi are used for
Depending on the dosage form and form of the hair restorer, drying, concentration, dilution, or the like may be optionally performed and adjusted.

The production method is not particularly limited, but may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After the extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.

The extract of yak of the present invention can be contained in a hair restorer / hair restorer, but the content thereof is not particularly limited, but the type, quality and expected effect of the hair restorer / hair restorer can be contained. Although it slightly varies depending on the degree, it is usually 0.5% by weight or more (hereinafter, expressed in terms of% by weight), and preferably 5 to 99%.
If the content is less than 0.5%, the effect cannot be expected sufficiently.

Similarly, various plant extracts of the present invention, such as aloe vera, enmeiso, ogon, panax ginseng, hypericum, kouboku, comfrey, cherry, salvia, perilla, peonies, stevia, sembi, hange, hyohugi, bukurojo, bodaiju, and buttonpi Although the substance can also be contained in the hair growth and restoration agent, the content thereof is not particularly limited, but slightly varies depending on the type, quality, and expected degree of action of the hair growth and restoration agent. 0.5% by weight or more (hereinafter, expressed by weight%), preferably 5 to 50%. If the content is less than 0.5%, the effect cannot be expected sufficiently.

The hair-growing / hair-growing agent of the present invention may optionally comprise, in addition to the above-mentioned essential substances, any of the following components and additives within the range not impairing the effects of the present invention. Can be manufactured.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, soybean oil, camellia oil, corn oil, rapeseed oil,
Persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) .

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic Surfactants, ether ester type nonionic surfactants, ester type nonionic surfactants, block polymer type nonionic surfactants, nitrogen-containing nonionic surfactants), other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water or a water-soluble organic solvent (eg, ethanol) ,Propylene glycol,
It is desirable to use one or a mixture of two or more selected from 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after the extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Giving flexibility, relieving irritation, relieving stress by aroma, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, alleviation of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

Specific plants (crude drugs) as raw materials include:
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsumuraji (Kibo), Acacia, Akashoma (Akashoma), Akasuguri "fruit", Akagrape, Akaminoki (Logwood), Akamegawiwa (Akabu Kashiwa), Akane
(Akane grass root), Acacia elegans or Jiou (Jihuang), Agi (Awei), Akinire (Royu skin), Aguahe (Omitengu palm), Akebi (Kidori), Asa (Ajihito), Malva Asagao or Asagao (Towushiko) , Hydrangea (hydrangea), ashitaba (morning leaves), azuki (red azuki bean), acerola, asenyaku (asenyaku), acira (shokuyoukanna), anise, abemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaper, Amadorokoro (Jade bamboo), Amana (Kojimitsu), Amaranthus (Hyuyu, Hagaito, Himogeito, Senninkoku,
Japanese cedar
(Haribiyu, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Algarrobo (cabbage),
Althea, Arnica, Alpinia or Katsumadai (Sou-zuku), Angelica, Apricot or Hong-apricot (Almond),
Ansokko (benzoic), Ikakozolina (bile head), Epimedium or Epimedium (Ino-kaku), rush
(Wicked grass), Knotweed (Tiger root), Yew (1st), Strawberry,
Figs (fructose `` fruits and leaves ''), Ichihatsu (primary), ichibi (winter aoiko), Ichiyakusou (one medicinal herb), ginkgo (ginko `` seed and leaves ''), Itohimehagi (enshi), carob, and locust bean (Telexa) , Inubeil (Honagainubeil), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou, nettle, ylang-ylang, iwa-tobacco
Iwahiba or iwamatsu (makikashiwa), oolong tea, fennel
(Fenka), Wheat (Chibusanoki), Ukiyagara (Sanryong), Uguisukagura `` fruit '', Himeukikyo, turmeric (Utsukin), Duckweed (buoying), Usubasaishin or Keirinsaishin or Oushusaishin (spicy), Usveniaoi , Utsubenitachioi, Utsubogusa (summer hay), Udo or Shishiudo (Qang activity, independent activity, Tang alone activity), Unyadegato (Uncararia, Cat's claw), Uba tea, Ume (Oume `` seed,
Pulp ''), Vulgaris, Uwaurushi (Kusaco peach),
Unshuang Mandarin (Chen Skin), Estragon, Eleuthero
(Ezo Goka), Echinashi (Hoshibamurasakibarengiku), Enishida, Enokitake (Enokitake), Ebisugusa or Cassia.
Tora (Keiko), El Campre, Elderberry "fruit", Elemi, Elingy or Pre Lotus Elinge,
Ende (Gossip, Gossip rice), ogi or Kibana-ohgi (Assembly Radix), Ouren (Yoren), Ookarasuri (Karokon), Ooguruma (Public incense), Ootsu-la-Fuji (self-defense), Oobako
(Worm child, Wrong grass), Toucan (Haruko), Oobanokera or Okera (white ajutsu), Oananasarusuberi (banaba),
Obanayabashi `` fruit '', haw hawthorn or hawthorn (Yamako), oyster (narco lily, Kagikurumabanaruko lily), ohisasanoyuki or sasanoyuki, barley
(Barley), giant croaker (cereal grass), oka, okazeri (snake bed), ogurma (turnover), okra `` fruit '', ginseng (carrot), odorisou (intermittent), onamimi (blue ears),
Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Oniyuri or Sasasayuri or Hakatayuri (Yuri), Ononis, Halibut (Hibaha Yu), Ominaeshi (Loose), Oyuko, Dutch mustard (Crasson), Dutch jelly , Dutch honeybee, olives "fruits, seeds, leaves", oregano, oranges "fruits, pericarp",
Kaikai Soji (ripe yellow), cacao `` fruits, peels, seeds '', oysters (persimmon `` leaves ''), kagikazura (fishing hooks), oysters or kantosou (lotusenso), cassia, casino ), Gajutsu (shajutsu), Kashiwa (shaki, shaba),
Cascarilla, Cascara sagrada, Kanixa (Kin Sato), Kaniwa, Kanokiso (Yoshikusa root), Birch or Weeping birch (White birch), Pumpkin, Capoknoki `` seed, '' Kahokokusansho (shopper), Gama (bamboo), chamomile or Rome Chamomile, camomites (weeds), camucum (duckweed), crows or cinnamon cucurbite (gold melon), oats wheat, guarana `` seed '', karaya, karin (gourd), garcinia, kawamidori, kawara saico (commissioned vegetables, invertebrates), Kawazusha, Kawatake mushroom, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawarangin carrot (blue koo), Kawamuragi (Inchinko), Kansui (Susumu), Licorice (licorice), Kantarasa, Candelilla, Kanto, Kanna , Strawberry
(Ezo strawberry, Dutch strawberry, Shrimp strawberry, Sawberry strawberry, Maple strawberry, European strawberry), Kiwi `` fruit, leaf '', Kikarasuuri (Ururone), Kikyo
(Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Chrysanthemum, Drosophila), Catalpa (Azumitsu), Cedar (Yotei root), Pheasant (Kikumi), Kizuta, Kidachiha, Kina, Kinoki (Shincona, Red linden), Quinoa (Kinoa) ), Yellowfin (yellow), gymnema sylvesta, cabbage, cabbage `` immature fruit '', cucumber, gyoryu (Nishikawayanagi, teriyaki), Kiraja saponaria, Kiraya, Kiranso (gold pea grass), kumquat `` fruit '', betel, Agrimony (Senraku grass), Guava `` fruit '', Guayule, Quercus infectria (Gallery), Kukui nuts, Kuko (Gugi, Gyugia, Gyugia leaves, Skeletal bark), Kusugi kazura (Tenmen winter), Kuzu (Kuzukone),
Camphor tree, gooseberry `` fruit '', ginseng, yellow gardenia, gardenia, kunugi, kupuasu,
Kumazasa, Kumamatsuura (horse whip grass), Clara (bitter butter), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit /
Leaf '', buckthorn, black squirrel (needs rescue), clove (cinch, cinch), gumbinazuna (sekimei, sekimeishi), kaygai (infestation, thorny spikelet), celosia (rooster corolla, rooster), bayberry (laurel tree), Kenashi Sartorii rose (Tokubukuryo, mountain return), gentian, genoshoko (Oirou grass), Kemponashi (Kigushi), Koukisekokukoku, Kishumican (Koji, Tachibana, Obeninican, Fukuremican, Sagamikouji, Ponkan, Santara (Tachibana skin)), Kousinbara (Tachibana skin) (Monthly flowers), Kosui mint, Kozo `` fruit '', Kocha (tea), Kouhone (river bone), Kouhon (straw, Kara straw), Kouriang, Kourikyo (Korajang), Koendro `` fruit '', Kouren (huohren), Cowberry (Koshibachi), Coco palm "fruit", Goshuyu (goshuyu), Goshoichigo (covered bonko), pepper (pepper), Kopaibabal Mug, coffee `` seed, leaf '', kobushi or magnolia (hot spring), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame croaker (gensin), goji (gomiko), Sanekazura or binankazura or Matsubusa, wheat (wheat) Wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata "seed", cola vera "seed", fenugreek "fruit", colombo, kondurango, kelp, konjac, sisal
(Sisal Asa), Sakisima button or Sinako button or Shina sensou (weird spirit), Sakura (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyayamasakura, Someiyoshino, Takanezakura,
Kasumi sakura, Choujizakura, Kohigan, Satozakura, Kanzakura `` flower, fruit, bark (cherry bark) ''), cherry, pomegranate, sasa, sasanqua, sagemodaka (sawatachi), sweet potato, sugar cane, sugar beet, saccharomyces japonicus Safflower, West Safflower), Pomelo "Fruit", Soapwort, Salmonberry "Fruit", Sarasinoshima (Masahima), Sawagikyo (Yamakona), Sawagurumi
(Sanguromo), Sangre degrad (croton), Sansouyousou, Sansin ginseng (San carrot), Sanshuyu (sanshuyu), Sansho (sansho), Sandzukon (Yamane root), Shea
(Karite), Cyano (fruit), Shiitake (Shiitake), Sion
(Shizono), Red squirrel, Shikunshi (Kimiko), Perilla or Aodiso or Chirimenzo or Katamamenji (Shizo), Rosewood, Shinanoki, Shinanohonoki, Chinese forsythia
Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiroishishimeji, Bunashimeji, Honjimesi, Shirotamogitake), Shimotsusukesou, Potato, Shajin (Shasan), Jasmine (Matsurika), Janohige (Motomonto), Shukushamits , Jujudama, Palm "fruit", Ginger (Ginger), Giant Hydrangea (Tsaneyama), Shobu
(Irises, iris roots), shojiku `` fruits '', shirakashi `` seed '', white walnuts `` seed '', white adzuki bean (chicken bone), white iris (small iris), white napatsuta `` flower '', white nanten (minamitenmi), shinkonasakushi Rubra, Jinkoge (Mizuka, Mizuka, Shencho), Cinnamon, Watermelon (watermelon), Honeysuckle (gold and silver flowers, Shinobi), Suiba
(Acid model), Swimberry "fruit", Strawberry "fruit", Suzu Psycho (Lord Xu Chang), Horsetail (Thorn), Purslane
(Horse Tongue, Horse Tongue), Plum (fruit), Pinus sylvestris (cone), Larch, L.
Walnut, Atlantic hawthorn, Atlantic dandelion, Horse chestnut (Marronnier), Atlantic pear `` fruit '', Atlantic seaweed, European elderberry, Elder tree (Juniper, Juniper), European yarrow (Europea japonica), European wildflower , Mistletoe, common mint or common wild mint, horseradish, horseradish, sekisho (stone iris), seaweed (stone mackerel), sedron (bowshokuboku),
Mallow, hirohase nega, senega, seri, celery, senkyu (river kyu), senshinren (shinshinren), sendan, senna `` fruits and leaves '', senninsou (large tate), souka
(Grass), buckwheat `` seeds '', soybean potato, rhubarb (daioh), radish, soybean, daidai (orange, kikomi), takasaburo (dry lotus grass), takatodai (daigei), takawarabi (gull),
Dark sweet cherry "fruit", hollyhock, hollyhock (thyme, morika), hollyhock (hikari), hollyhock, tamarind "seed", onion, tamashiba
(Spicy), Tara tree `` fruits, leaves, root bark '', tarwi, tanjin (dansin), dandelion (Kabukohide) or white dandelion or moko dandelion, dammar, cherry `` fruit '', tigaya `` fruit, root, bud '', chiksetsu Carrots (bamboo ginseng), chicory, chancapiedra (Kidachikomikansou), Korean daisies (Ohio), Korean lance (Wuyi), Korean sagebrush (Aiba), Choreimaitake (Iori), Tsukimiso, Tsukutake (mushroom), Camellia , Asparagus,
Tsumekusa (lacquer lacustrine), twigweed (duckling grass), vine adzuki (red azuki bean), tsuldokudami (what crow), tsuruna (banyou), tsujin carrot (four-leaf ginseng), tsuwabuki, deiko, teuchigurumi, duberry `` fruit '', tengusa, tencha (Tea), Touga
(Winter gourd), toukazukizura, pepper (bancho), touki
(Toki), Tokinsenka (marigold), Touna Bena
(River cut), corn or corn hair (Nanbaru hair), horned rat horn (Female Sadako), turmeric or Korean gentian (dragon and gall), toxa (pirate), dokudami (jujube), konkon
(Spot), Toshishi or Mamedashi or Nerashikazu, Eucommia (Tonaka `` bark, leaves, roots ''), Ash (Qin bark), tomato, tragacanth, Triacanthus `` seed '', Tormentilla, Dronoki, Trolo aoi, Niseria berry `` Fruit '', Chinese yam or yam (Yamayaku), Nagikadida (Butcher Bloom), Naginata Kouju, Nazuna, Rape, Rape bean or Haricot (sword bean), Natsumikan, Jujube
(Dajutsu), Naniwaibara (Kanekurako), Navena (Continuous), Nameko, Narco lily (Yoshisei), Peanut (peanut), Nanten (Minami Tenmi), Nambangarashi (ramie), Nigaki (Makiki),
Artemisia (bitter mite), nutmeg, cay or nikkei or ceylon nikkei or yabnikkei (cinnamon bark) or Keishi (keiseki), leek (niriko), elderberry (grafted tree `` fruit, flower, stem,
Leaf)), garlic (garlic), nulde (fivefold), leek, nemuki or neb or nebi or nemuriki or digokubana
(Healing), Thistle (Ohi), Noibara (Fruit), Yarrow, Nodake (Maehu), Nobara, Nomomo, Palm, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hakamauraboshi (Bone Crushing) , Hachsen (ringworm skin), Huckleberry "fruit", chickweed (red),
Hazel (Haruko), Hasiridokoro (Rot root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley (Netherland jelly), Naked worm, Batata, Hachik or Madake (Bamboo-boiled), Patchouli, Minka (Light load, Light load leaf) , Adlay (Yokuinin), Hanasuge
(Chimo), Banana, Hanamint, Hanabishi (Siturishi, Shisitsuri), Vanillabins, Papaya, Scotch (Rice malt grass), Pahalobobo, Hub `` Whole grass, stem, leaf '', paprika,
Hamago or Mitsuba Hamago (vine thorn), Hamasuge (Katsuki), Hamabishi (Shiritoko), Hamanas (maikai flower), Hamaboufu (beach windbreak), Hamamelis, Rose (rose), Haratake (Haratake, Shirooharataketake, Usukimorinokasa) ,
Haran, Parietaria, Balsamina (Tsurureishi, Nigari), Harunire (Yellow, Yuhakuh, Yuha), Handaikai (Greamy Sea), Breadfruit, Hikagetul Ginseng (Party), Puer Tea (Pulse Tea), Pecan Nut, Chestnut (Shiruru, Tossana Hana), Hishi (Hishimi), Pistachio, Beet, Hitotsuba (Ishire), Hitotsubenisida, Hinata Kozuchi
(Cow knee), cypress, hiba, castor, sunflower, pepper,
Himeuzu (Aoi), Himegama (incense crab), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Bjackyu, Hiyu `` Fruit '', Bilobaoi,
Hiro-Okinagusa (Hakuto Okina), Loquat `` Fruits, Leaves, Stems '', Betel Nuts (Large Cloth, Betel Loaf), Butterbur Kazura (Southern Rattan), Butterbur, Butterfly Poppy (Foliage Flower, Winter Leaves), Fuji Bacama (Rancho), Fuji Bean (Tan Bean) ), Grape "fruit, peel, seeds,
Leaf '', beech, sycamore (caterpillar), licorice brazilian, carrot, black currant `` fruit '', blackberry, plum `` fruit '', flucellaria, blueberry (Prunus avium), prunes,
Blond Psyllium, Bundo (Mung Bean), Loofah, Safflower (Safflower), Henneken, Belladonna, Berry `` Fruit '', Peruvianberg, Benkeisou or Duckweed (Keiten), Boysenberry `` Fruit '', Broomfruit or Niwaxa or Nendou or Hahagigi Kokia (Dermatology), Balsam (Fozen, acute child, osteophyte), Bofu (windbreak), spinach, physalis (Torone), honoki (Japanese thick, park), bokeh
(Gourd), Hosovanaokera (Sojutsu), Hosobanokirinsou
(Kageten Sanshichi), Hosobabarengiku, Button (peony `` flower,
Leaves, stems)), hops, jojoba, bordeaux, white berries, berries, hon-oniku (meat porcelain, daigei), hon-sekkoku (iron bark stone, sparrow mountain stone mascara), misuzunennanshaw
(Tennan star), Maitake (Maitake), Ephedra (Maohu), Maca, Macadamia nuts, Macri (Martian grass), Magwa (Mulberry white bark `` bark, leaves ''), Mashua (Tamanouzenharen, Kyuukonkinrenka), Matatabi (Kiten Tate), Matsukasa, pine "leaves,
Bark, roots '', matico (cordoncillo), mayolam
(Hanamint), Malvanojazine (Bitterfruit), Mulberry `` Fruit '', Quince, Mango, Mangosteen, Mansagna (Andesca Mitsure), Manshu Gurumi, Mandarin `` Fruit '', Mannentake (Lingzhi), Pheasant (Kikomi `` Fruit ''), Mishimasaiko (Saiko), Mizuobako or Mizuasagao (Ryugoshi), Mizokokushi (Hanabe Lotus), Misohagi (Chisatsuna), Michiyanagi or Elegant willow (Henzo), Mitsugashiwa,
Honey, green mint, mimosa, mioga, miracle fruit `` fruit '', myrrh, mirobaran, mukge
Mukunoki, Mukuroji (prolonged skin), Munya, Murasaki (purple root), Murasakisikibu or Omurasakikibu (purple),
Purple maize, purple purple sorghum (Kunming chicken blood wisteria), red sea squirrel (mother grass), red seaweed, melaleuca, melissa, melilot, melon `` fruit '', sorghum, sorghum, sorghum,
Maple blossom, peach (peach "leaves, seeds, flowers, fruits"),
Bean sprouts, morello cherries "fruits", morroheiya (burlap),
Yakawamurasaki potato, yakuchi (masuchi), cornflower (cornflower), cornflower mint, yakon, yashabushi
(Yagi) or Himeyashabushi or Obayashishabushi `` fruit, peel, ears '', yachiyanagi, yatsude (octagonal metal plate), mistletoe (willow parasitism), willow (kawayanagi, tachinyanagi, weeping willow, red willow, pussy willow, inuyoriyanagi, ryeko Willow, willow willow, willow willow, willow willow, willow kinuyanagi, fox willow, dronoki), willow leaf
Stalk '', scabbard, savannah koji (purple beef),
(Tsurusu, Tenmei), pokeweed (land), yamanoki (mountain harbor), yamamomo (yangmei), sagebrush, eucalyptus, yukinosita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, yorigusa , Mugwort (Aiba), reigan (Rainuma), lime "fruit", rye, lakanka "fruit",
Raspberry `` leaves, fruits '', Latania (Clameria), Rakkyo or shallots (Shiroi), lavender, longan (longan meat), agave (Aono agave,
Fukurin agave), Ryokucha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, rubus or suavisimus (sweeten), litchi (lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', Lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, wax palm, locust (reed, azuki), loganberry `` fruit '', rosemary (mannen wax), rose hip (nobara), wasabi, waremoko ( Jiyu) and the like.

Further, other seawaters, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango) Species, for example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water).

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaa nori, Susiaonori, Hiraaonori, Bowaoonori, Hosoedaoonori), and seaweed [brown alga: Kombu alga; , Resilicon b, hosomekobu, mishitishibu), seaweed, hirome, blue seaweed, giant kelp (macrocystis pirifella, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata), seaweed [red alga: hijirimen, maxa] Tengsa),
Hirakusa, Omikusa, Obakusa, Katao Bakusa, Yatabegusa, Yuikiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Zyakushinkirinsai, Tsunomata, Obatsunomata, Tochaka , Ibotsunomata, Yaleus Banori, Kagius Banori,
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tulsimidro, Hibimidro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaet, Genus Genus genus, Species of the genus Cyperaceae: Species of the genus Cyperaceae, the genus of the spider genus;

Blue-green algae (Genus L .: L., L., L., L .: L., mushrooms,
(Hassay, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Spirogyra spp .: Namiami spp., Isogrape spp .: Isogrape,
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Icmegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Urushigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Filiformis, Genus Turmo: Genus Tsurumo, Genus Anana: Genus Anastasia, Genus Suzume: Genus Musicum, Genus Missiscoma, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochimitsu-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombu genus: Kikuishikombu, Nejirekombu: Nekorecome genus, Kuroshimae : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hokumoku, Tamamomoku, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitrano, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Obanoki-mimoku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russula genus: Rush genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashigenus: Isobashi, Fujimatsumo Genus: Fujimatsumo, Sawwort: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

Axle algae (Characta spp.
L. genus: L., Lychnotanus, L. genus: L., L., etc., Yellow algae (L. genus: L.).

Materials derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow stomach, duodenum or intestinal extract or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran ferment extract, euglena extract, lactic acid fermentation of raw milk or skim milk powder, and trehalose Or a derivative thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, monodiparamethoxycinnamate
Glyceryl-2-ethylhexanoate, salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.

(19) Tyrosinase activity inhibitor Vitamin C acid or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E Or a derivative thereof, N-acetyltyrosine or a derivative thereof,
Glutathione, hydrogen peroxide, zinc peroxide, placental extract,
Ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, squash, stalk, mulberry, clam, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, adlay barley, odoris persica, hops, hawthorn, eucalyptus, achillea millefolium, altea, keiskei , Mankeishi, hamamelis, yamaguwa, prolonged life grass, bellflower, toshishi, successor sprout, sun dried, mahuang, senkyu, dokkatsu, psycho, boufu, hamabofu, ougon, peony skin, peonies, genoshoko, kakkon, licorice, quince, aloe, shoma , Safflower, green tea, black tea, asenyaku), etc.

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, Horsetail, Gentian, Burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemblage, Touki, Tokinsenka, Amacha, Hypericum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C acid or its salt, stearic acid ester, vitamin E or its derivative, nordihydroguaseletenic acid,
Butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol and the like.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clove, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Tenmi,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octyl phenyl ether), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitive No. 201, Photosensitive No. 401, N-long-chain acyl-basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Natto extract, etc.

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, sage, Atlantic elderberry, bollige, buttonpi), seaweed extract and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, garlic extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Topical stimulant Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activators Photosensitizer No. 301, hinokitiol, pantothenic acid or a derivative thereof, allantoin, placental extract, biotin, glyceride pentadecanoate and the like.

(35) Antiseborrheic agents Pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dye agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, Coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Greater Fengxiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batturi essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils, Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and anti-allergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bitters, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

Further, the dosage form of the hair-growing / hair-growing agent of the present invention is arbitrary, and is used by mixing in the form of capsules, powders, granules, solids, liquids, gels, air bubbles, emulsions, creams, ointments, sheets and the like. be able to.

Specifically, for example, external pharmaceutical preparations, cosmetics such as creams, lotions and oils, shampoos,
Can be used for rinsing, hair treatment, hair cream, pomade, hair spray, hair styling, perm, hair tonic, hair dye, hair growth and hair restoration, hair washing and hair cosmetics, and other general foods and beverages It is.

The method of adding to the hair-growing / hair-growing agent of the present invention may be added in advance or during the production, and may be appropriately selected in consideration of workability.

[0092]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and prescription examples, but the present invention is not limited to these examples.

(Preparation Example 1) Plants of eel, aloe vera, emmeso, ogon, panax ginseng, hypericum, kouboku, comfrey, cherry, salvia, perilla, peonies, stevia, sembi, hange, hyopus, bokuryo, bodaiju, and buttonpi 100 g of each was warmed and extracted with purified water (about 80 ° C.) for about 5 hours, and filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.08 to 3.0% by weight).

(Production Example 2) Plants of yak, aloe vera, emmeso, ogon, panax ginseng, hypericum, kouboku, comfrey, cherry, salvia, perilla, peonies, stevia, stevia, assembly, hange, giant gourd, bakuryou, bodaiju, and buttonpi 100g each
After being immersed in a 50% ethanol solution and extracted at room temperature for 5 days and nights, it is filtered and the extract (dry solid content: about 0.1 to 3.0% by weight)
About 1.0 kg.

(Production Example 3) Plants of eel yak, aloe vera, enmeso, ogon, panax ginseng, hypericum, kouboku, comfrey, cherry, salvia, perilla, peonies, stevia, sembria, hange, giant olive, bokuryo, bodaiju, and buttonpi 100g each
Immerse in 70% ethanol solution or 30% 1,3-butylene glycol solution, 60% propylene glycol solution or purified water (about 30 ° C), extract at room temperature for 5 days and nights, filter and extract (dry) Solid content: about 0.1-3.0% by weight) about 1.0k
get g.

(Test 1) C3H mouse hair growth promotion test Approximately 8 cm ² of the back of the animal was shaved with an electric clipper and an electric shaver. Next, apply the sample once a day to the depilated back about 0.2 ml.
Was applied 5 days a week for 20 days. On the 12th and 20th days after application, the area ratio (%) at which hair regeneration was observed relative to the area from which the hair had been removed was measured with an image analyzer, and compared with the control group. The results are shown in FIGS. "Ogawa et al.'S test method (Flexibility Journal, Vol. 17, No. 5, P. 20-29 (1989)
reference"

(Test Method) a. Sample The yak extract obtained in Production Example 2 of the present invention was used as an undiluted solution, and the yak extract and other plant extracts were mixed and used in equal amounts. As a control, only a 50% aqueous ethanol solution of the base was used. As a positive control, minoxidil was dissolved in a 50% aqueous ethanol solution at 0.5% (w / v), and aloe vera, enmeiso, ogon, panax ginseng, hypericum, kouboku, comfrey, cherry,
Plant extracts (stock solutions) of Salvia, Perilla, Peony, Stevia, Assemblage, Hange, Hiogi, Bukuryo, Bodaiju, and Botanpi were used. b. Experimental animals 8-week-old male C3H mice were used. These animals are at room temperature
22 ± 2 ℃, humidity 50 ± 15%, all fresh ventilation 15 times /
The animals were bred in a 9 hour / day lighting environment. Animals had free access to solid feed MF (Oriental Yeast Industry) and tap water.

(Test Results) As shown in FIGS. 1 and 2, the ejaculate extract of the present invention showed significant hair regeneration. In addition, at least one plant selected from aloe vera, emmeso, ogan, panax ginseng, hypericum, kouboku, comfrey, cherry, salvia, perilla, peonies, stevia, assembly, hange, giant forsythia, bakuryo, bodaiju, and buttonpi with the eel extract Regeneration of hair was also significantly recognized in the case of using the extract in combination.
In addition, compared with minoxidil or various plant extracts alone,
Almost the same or more hair regeneration is observed, hair restorer,
Can be used as a hair restorer.

(Test 2) Safety test (1) Primary skin irritation test The various plant extracts obtained in Production Examples 1 to 3 were prepared with purified water so that the dry solid concentration was 0.5%. Japanese white rabbit with shaved back (female, 3 per group, weight around 2.3kg)
Was applied to the skin. At 24, 48 and 72 hours after application, evaluation was performed using erythema and edema as indices based on the criteria of Draize. As a result, no erythema and edema were observed in all animals, and it was judged that there was no problem with regard to primary skin irritation.

(Test 3) Safety test (2) Skin cumulative irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared with purified water so that the dry solid content concentration was 0.5%. Hartley guinea pig with shaved back (female, 3 per group, weight 32)
0.5 g / animal) was applied to the skin (about 0 g) once a day, 5 times a week. Application was performed over two weeks and shaving was performed on the last application day of each week. Evaluation was performed using erythema and edema as indices based on the criteria of Draize on each application day and the day after the last application day. As a result, no erythema or edema was observed in any of the animals for 2 weeks, and it was judged that there was no problem with respect to the cumulative skin irritation.

(Test 4) Safety test (3) Single dose toxicity test The various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%. kg quantity,
Before the test, ddy mice (male and female, 5 animals per group, 5 weeks old) which had been fasted for 4 hours were orally administered, and the appearance and degree of toxic symptoms were observed over time. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, the LD50 was 2,000 mg / kg or more, and it was determined that the substance was safe.

(Prescription example) Production of hair growth / hair restorer In accordance with the above-mentioned evaluation results, the following formulation examples are shown. Each formulation example may be one manufactured by a conventional method in the manufacture of each product. showed that. Further, the present invention is not limited to these.

(Formulation Example 1) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. A: Yaku 50% ethanol extract B: Aloe vera 50% ethanol Extract C: 50% ethanol extract of E. ginseng D: 50% ethanol extract of pentagon E: 50% ethanol extract of Panax ginseng F: 50% ethanol extract of Hypericum G: Kokuboku 50% ethanol extract H: Comfrey 50% ethanol extract Liquid I: Sakura 50% ethanol extract J: Salvia 50% ethanol extract K: Perilla 50% ethanol extract J: Peony 50% ethanol extract L: Stevia 50% ethanol extract M: Assembly 50% ethanol extract N: Hange 50% ethanol extract O: Hiogi 50% ethanol extract P: Bukuroyou 50% ethanol Extract Q: Bodaiju 50% ethanol extract R: Bodampi 50% ethanol extract * A extract 5.0 * One of BR to R extract 5.0 5.Preservatives qs 6. Purified water 100 Residue

(Formulation Example 13) Shampoo weight% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6. Yak 50% ethanol extract 10.0 7. Comfrey 50% ethanol extract 10.0 8. Sakura 50% ethanol extract 10.0 9. Rosemary 30% ethanol extract 1.0 10. Collagen hydrolyzate 1.0 11. Antibacterial and antiseptic Agent (thiamine lauryl sulfate) appropriate amount 12. pH adjuster appropriate amount 13. perfume (thin water) appropriate amount 14. Purified water 100 residue

(Formulation Example 14) Rinse weight% 1. Stearyl trimethyl ammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Yak 50% ethanol extract 1.0 6. Hange 50 % Ethanol extract 1.0 7. Peony 50% ethanol extract 1.0 8. Trehalose solution 1.0 9. Hydrolyzed silk solution 1.0 10. Appropriate amount of antibacterial and preservative (benzalkonium chloride) 11. Appropriate amount of fragrance (chamomile water) 12 .Remaining amount of purified water 100

(Formulation Example 15) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Yakaku hot water extract 1.0 6. Koboku 50% hot water extract 1.0 7. Hyote 50% 1,3-butylene glycol extract 1.0 8. Carpronium chloride 0.3 9. Hinokitiol 0.5 10. Keratin decomposition solution 1.0 11. Antibacterial and preservative (paraben, benzalkonium chloride) Appropriate amount 12.Fragrance (apple water) Appropriate amount 13.Purified water 100 residue

(Formulation Example 16) Hair tonic weight% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Yak 50% 1,3-butylene glycol extract 5.0 5. Stevia extract 1.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 6. Bulk root 50% 1,3-butylene glycol extract 5.0 7. Nicotinic acid benzyl ester 0.5 8. Sodium hyaluronate solution 1.0 9. Carboxyl Methyl chitin solution 1.0 10. Whey solution 1.0 11. Vitamin B6 solution 1.0 12. Mucopolysaccharide solution 1.0 13. Mentha oil 0.1 14. Antibacterial and preservative (paraben) 0.1 15. Appropriate amount of fragrance (rose water) 16. Purified water 100 And the rest

(Formulation Example 17) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Yak 50% propylene glycol extract 5.0 3. Bodige 50% propylene glycol extract 2.0 4. Bodampi 70% propylene glycol extract 2.0 5. Vitamin E derivative 0.5 6. Pepper tincture 0.5 7. Resorcin 0.5 0.5 Glycyrrhizic acid 0.5 9. Hydroxypropyl chitosan solution 0.5 10. Beef hematin solution 0.5 11. Thympi 50% propylene glycol extract 2.0 12. Birch 50% propylene glycol extract 2.0 13. Amino acids (glycine, glutamine, etc.) 0.5 14. Antibacterial and preservative (paraben) 0.1 15. Perfume (rosemary) qs 16. Purified water 100

(Formulation Example 18) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Yaku 50% 1,3-butylene glycol extract 5.0 3. Koboku 50% 1,3-butylene glycol extract 5.0 4. Sakura 50% 1,3-butylene glycol extract 5.0 5.cantaris tincture 0.5 6.pantothenic acid derivative 0.5 7.resorcin 0.5 0.5 glycyrrhizic acid 0.5 9.salicylic acid 0.5 10.hydroxyethyl chitosan solution 0.5 11.elastin hydrolyzate 0.5 12. Astragalus 50% 1,3-butylene glycol extract 2.0 13. Soybean 50% 1,3-butylene glycol extract 2.0 14. Elastin hydrolyzate 0.5 15. Antibacterial and preservative (paraben) 0.1 16. Perfume (lavender) 17.Purified water = 100

(Test 5) Use effect test The effect when the hair growth and hair growth agent of the present invention was actually used was examined. The test used was a panel of 10 people (25-50 years old) complaining of alopecia and alopecia. The hair of Formulation Example 1 was used twice daily, morning and night (after washing the hair at night), twice in total. The usage test was performed by applying an appropriate amount (about 5 ml) of the tonic to the scalp for 3 months. Controls include a hair tonic containing only one of the various plant extracts of the present invention (excluding ejaculate extract), and a product prepared by removing the various plant extracts of the present invention in the same manner. Was used. The evaluation was performed according to the following criteria, and the results are as shown in Tables 1 to 4, and the numerical values in the table represent the number of persons. No one complained of scalp / hair abnormalities during the use period.

"Hair-growing / hair-growing effect" Efficacy: Extremely large amount of downy hair was produced. Slightly effective: slight downy hair was generated. Ineffective: No change from before use.

"Effect of improving hair feel" Efficacy: The gloss, tension, and smoothness of the hair were increased, and the combing was extremely improved. Slightly effective: The gloss, tension, and smoothness of the hair were slightly increased, and combing was slightly improved. Ineffective: No change from before use.

[0113]

[0114]

[0115]

[0116]

(Test Results) As shown in Tables 1 and 2, the eel extract of the present invention or the eel extract together with aloe vera, enmeso, ogon, panax ginseng, hypericum, kouboku, comfrey, sakura, salvia, perilla, peony , Stevia, Assemble, Hange, Hiougi, Bukuryo, Bodaiju, Buttonpi
In the case where a plant extract of more than one species was used in combination, a large number of people with significant downy hairs were observed, and the hair growth and hair growth effects were confirmed even when compared with single various plant extract formulations.

(Test Results) As shown in Tables 3 and 4, the eel extract of the present invention or the eel extract together with the aloe vera, lime grape, pentagon, panax ginseng, hypericum, kouboku, comfrey, sakura, salvia, perilla, peonies , Stevia, Assemble, Hange, Hiougi, Bukuryo, Bodaiju, Buttonpi
A combination of plant extracts of more than one species gave gloss, tension and smoothness of hair, improved combability, and improved hair feel. In addition, it was also confirmed that the effect of improving the hair feel was stronger than that of a single plant extract compound.

[0119]

EFFECTS OF THE INVENTION The eel extract of the present invention or the eel extract together with aloe vera, enmeso, ougon, panax ginseng, hypericum, kouboku, comfrey, cherry blossom, salvia, perilla, peonies, stevia, semba, hange, giant oak, bakuryou Hair restorer and hair restorer combined with one or more plant extracts selected from sorghum, bodaiju, and buttonpig have excellent hair-growth and hair-growth effects, and give hair gloss, tension, and smoothness, and comb And it is safe for humans and animals. In addition, use for general foods and drinks is also possible.

[Brief description of the drawings]

[Fig. 1] Various plant extracts and monoxidil of yak, aloe vera, emmeso, ogan, panax ginseng, hypericum, kouboku, comfrey, cherry, salvia, perilla, peonies, stevia, assembly, hange, giant forsythia, bakuryo, bodaiju, buttonpig It is a figure which shows a reproduction | regeneration hair area ratio.

Fig. 2 Extracts of various plant extracts such as aloe vera, Japanese radish, Japanese gourd, Panax ginseng, Hypericum perforatum, Koboku, Comfrey, Sakura, Salvia, Perilla, Peonies, Stevia, Assemblage, Hange, Hiougi, Bukurojyo, Bodaiju, and Botanica It is a figure which shows the reproduction | regeneration hair area ratio at the time of containing one or more types.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification code FI Theme coat ゛ (Reference) A61K 35/78 A61K 35/78 TV W 35/84 35/84 A A61P 17/14 A61P 17/14 F Term (reference) 4C083 AA072 AA111 AA112 AA122 AC072 AC102 AC122 AC182 AC312 AC352 AC432 AC472 AC532 AC542 AC582 AC642 AC692 AC782 AC842 AC852 AC902 AD202 AD312 AD322 AD332 AD412 AD432 AD442 AD452 AD532 AD632 AD662 CC32 CC33 CC37 CC38 CC39 AB04 4 AB33 AB38 AB52 AB58 AB65 AB67 AB72 AB80 AB86 AC01 AC02 AC03 AC04 AC05 AC06 AC11 AC13 AC16 BA08 MA07 MA63 ZA92

Claims (2)

[Claims] (1) A hair restorer / hair restorer comprising an extract of yak. 2. An extract of eel yak and one selected from aloe vera, anchovy, giant gourd, panax ginseng, hypericum, kouboku, comfrey, cherry, salvia, perilla, peonies, stevia, sembria, hange, giant forsythia, boukuro, bodaiju, and buttonpi. A hair restorer / hair restorer comprising the above plant extract.