JP2001321121A - Hair growing and restoring food and drink - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new and safe hair growing and restoring food and drink having excellent hair growing and restoring effect, imparting the hair with luster, springiness and smoothness, improving the combing easiness and the feeling of the hair and safe to man and beast. SOLUTION: The objective hair growing and restoring food or drink contains an extract of various plants selected from Plectranthus rugosus, Panax ginseng, Hypericum erectum, Salvia officinalis, Ficus religiosa, Momordica grosvenori, Laminaria japonica, Hizikia fusifome, Fucus distichus and Undaria pinnatifida or a combination of the extract of one or more plants cited above with the decomposition product of one or more proteins selected from silk protein, keratin protein and collagen protein.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention
One or more plant extracts selected from Lacanca, Kombu, Hijiki, Hibamata, Wakame, or one or more plant extracts selected from Emmeso, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lakanka, Kombi, Hijiki, Hibamata, Wakame A hair growth-growing effect is recognized by using at least one protein degradation product selected from silk protein, keratin protein, and collagen protein together with the product.
The present invention relates to a novel and safe application to food and drink for hair growth.

[0002] The field of application is, for example, all kinds of internal preparations (including preparations for animals), and specifically, ampules, capsules, pills, tablets, powders, granules, solids , Liquids, gels or air bubbles 1) pharmaceuticals, 2)
Quasi-drugs, 3) foods and drinks (for example, oral compositions such as gum and candy, processed seafood products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese confectionery, raw noodles and yuden noodles) Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy, water syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, soy sauce, Processed vegetables and fruits, such as sprinkled or canned and bottled vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey beverages, soft drinks, alcoholic beverages, etc.) Other beauty foods
Use in general foods and drinks such as health foods (improvement of rough skin, improvement of skin quality, hair growth / hair restoration) is exemplified.

[0003]

2. Description of the Related Art Due to the increase in stress and changes in eating habits due to changes in the social environment in recent years, people suffering from thinning hair, hair loss, and circular hair loss are becoming younger at the same time. I have.

At present, the causes of hair loss are considered to be due to abnormalities in the endocrine system, abnormalities in the hair cycle, imbalance in the autonomic nervous system, nutritional disorders, stress, and other causes caused by hereditary and aging. Further, as a conventional hair growth and hair growth component, for example, linoleic acid monoglyceride (Japanese Unexamined Patent Publication No.
3-201114), estrogen (JP-A-60-3)
8313), etc., and vitamin E, B2,
Vitamins such as B6, biotin, pantothenic acid, and other amino acids (peptide substances:
No. 7209) and existing peripheral blood circulation promoters (vitamin E and its derivatives, garlic extract, cepharanthin, carpronium chloride, minoxidil, etc.), local stimulants (capsicum tincture, vanillamide nonylate, tincture tincture, peppermint oil, peppermint oil, benzyl nicotinate) And anti-inflammatory agents (glycyrrhizic acid, licorice extract, diphenhydramine hydrochloride, etc.) are known.

[0005] Then, the above-mentioned hair-growing / hair-growing components are used alone or in combination with a plurality of hair-growing and hair-growing components with the expectation of the effect.
Many are aimed at comprehensive hair growth and hair growth effects, such as promoting hair growth, preventing dandruff, Kayumi, inflammation, and preventing thinning and hair loss.

[0006]

SUMMARY OF THE INVENTION As described above, hair growth and scalp used for the purpose of growing or maintaining hair on the scalp and skin.
Various components and techniques have been proposed for hair tonics and are still in practical use at present. However, their hair restorer / hair restorer is not always effective enough to cause skin irritation and is not satisfactory in terms of safety.
Most of the scalp / skin hair was used externally to prevent hair growth, hair growth or hair loss.

In view of the above, attention has been paid to the action of converting the rest period of the hair cycle into the anagen phase, which has recently attracted attention. Considering the use as a hair growth and hair growth agent that eats active ingredients that could not be sufficiently supplemented with external preparations, The hair cycle stimulates the quiescent hair roots, and studies and pursuits of a hair-growing hair-restoring food and drink that are effective in speeding the transition to the anagen phase have been conducted, and intensive research has been conducted.

[0008]

In view of these circumstances, the inventors of the present invention have developed a useful plant and protein having a hair-growing / hair-growing effect as a theme of development. As a result, the present invention has been developed as follows. By eating plant extracts of Lakanka, Kombu, Hijiki, Hibamata and Wakame, hair-growth and hair-growth effects are found. It was found that the synergistic effect of hair regeneration was significantly recognized by eating, and that it had a hair-growth and hair-growing action. Further, the present invention has been accomplished by providing hair with a gloss, tension, and smoothness, and providing a highly safe hair-restoring food and drink with good combability.

[0009]

DETAILED DESCRIPTION OF THE INVENTION The term "enmeso-choi: life-prolonging grass" used in the present invention refers to a plant belonging to the Labiatae family and the genus Rabdosia: Rabdosia japonicu.
s (Burm.f.) Hara (= Isodon japonicus Hara) "or the above-ground portion or whole plant of Isodon trichocarpus Kubo.

"Ginseng: Panax ginseng" refers to a plant of the genus Araliaceae or Panax L .: Panax ginseng CAMey. (= P
anax schinseng Nees) "" Alias: Panax ginseng "

[0011] "Hypericum: younger cut grass" refers to Hypericum (Guttiferae), Hypericum (Hypericum).
Plants: Hypericum perforatum (Hypericum erectum Thunb.), Hypericum perforatum (Hypericum perforatum L.), Hypericumperforatum L. var angust
ifoliom DC).

"Salvia" refers to Labiatae,
Plants of the genus Salvia: Salvia officin
alis L.) Flowers or leaves of "alias: sage", whole plants are used.

"Bodaiju: Bodaiju" means plants of the linden family (Tiliaceae) and genus Tilia: Tilia platyphyllos Scop.
iliacordata Mill.), European linden (Tilia europae
a L.) or other closely related plant flowers or fruits, or bark.

"Lakanka: Arhat fruit" means Cucurbitaceae (Cucu
rbitaceae), a plant of the genus Momordica: Momordica grosvenorii Sw
ingle. (= Siraitia grosvenorii (Swingle) C. Jeffre
y) ”.

[0015] The term "kelp" refers to a brown algal plant phylum (Phaeophyta),
Heterogeneratae, Laminariale
s), Laminariaceae (Laminariaceae), classified into the genus Laminaria (Laminaria), a single leaf with no hair plexus, no mucous cavity, no middle ribs on the leaves, roots are fibrous, stems refer to algal bodies that do not branch, for example ,
Macomb (L. japonika Areschoug), Resiliconbu (L. jap
onica Areschoug var.ochotensis Okamura), L. religiosa Miyabe, L. angusta
ta Kjellman), L. coriacea Miyabe in
Okamura), Kakijima kelp "Enaga kelp" (L. longipeda
lis Okamura), L. diabolica Miyabe in Oka
mura), Gohei kelp (L.yezonsis Miyabe in Okamur)
a), Nagakombu (L. longssima Miyabe in Okamura), Peas (L. yendoana Miyabe in Okamura), Chimbu (L. cichorioides Miyabe in Okamura) and the like are listed as typical examples.

"Hijiki" refers to the brown algal plant phylum (Phaeophyt).
a), Meridian rope (Cyclosporeae), Hibamata (Fucales), Hondara (Sargassaceae), genus Hizikia (Hizikia). The undersea forest has roots, stems, leaves, and bubbles (floating bladders). Bubbles are typically represented by those in which cylindrical twigs are swollen to form a spindle or a club.

"Hibamata" refers to the phylum Phaeophyt
a), the class of the circle (Cyclosporeae), the order of the cypress (Fucales), the family of the cypress (Fucaceae), classified into the genus Hibama (Fucus), the cypress (F. Vesiculosus) (or F. distichus Linn
aeus subsp.evanescens (C.Agardh) Powll), whose body is membranous, with midrib, 20-50 cm in length, cold seaweed that grows in the middle and above the intertidal zone. It is raised as.

"Wakame" means a brown algal plant phylum (Phaeophyt).
a), Heterogeneratae, Laminariformes (Laminari
ales), Laminariaceae (Laminariaceae), Wakame (Undaria)
Algae that have hair plexuses and mucous glands in the leaves and fold at the bottom of the body, for example, seaweed (U. pinnatifida
Suringar), Hirome (U. undarioides Okamura), Blue Wheat (U. peterseniana Okamura) and the like are mentioned as typical ones.

The extracts of Glycyrrhiza paniculata, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca, Kombu, Hijiki, Hibamata and Wakame used in the present invention are:
Various parts of each plant (whole plant, fruit, flower, leaf, bark,
Roots, stems, algae, etc.) are crushed and then squeezed.
Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol, and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, and ethyl. Ethers, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene, chloroform can be used alone or in any combination of two or more,
Each solvent extract can also be used in combination.

Although the production method is not particularly limited, it may be usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or use of an ion exchange resin is carried out.
A solution, paste, gel, or powder may be obtained by decoloring and purifying. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to an extracted substance may be arbitrarily selected.

As a raw material of the "silk protein", a silk fibroin protein or a silk sericin protein prepared from silk can be used, and as a production method, it can be produced directly by an acid, an alkali or an enzyme or by a decomposition by a bioreactor method. For example, it can be manufactured as follows.

The silk is first heated to 80 ° C. or higher and sterilized by heating.
This is heated and dissolved in a high-concentration salt solution such as lithium bromide, magnesium nitrate, calcium chloride and the like, and then desalted by dialysis, reverse osmosis or the like, and then a protease is allowed to act. Examples of the protease include trypsin, chymotrypsin, papain, pepsin, rennin, pancreatin, elastase, carboxypeptidase, aminopeptidase, dipeptidase, and alcalase. 37 ° C,
Operate under pH 7.0 condition. In this case, preferably 24
After decomposing aseptically over time, the temperature is raised to 80 ° C. or higher to deactivate the enzyme, and then the precipitate is removed by centrifugation to obtain a degradation product derived from silk protein. This is powdered by spray drying, freeze drying or the like.

As a raw material of the "keratin protein", a protein prepared from feathers, wool or the like can be used. Production methods include alkali decomposition, oxidative decomposition with inorganic acids and organic acids, reductive decomposition with a reducing agent, and direct decomposition with enzymes. Alternatively, it can be produced by decomposition by a bioreactor method. For example, it can be produced as follows.

Hydrochloric acid is added to the feathers, and the feathers are subjected to a decomposition treatment at 100 ° C. for 15 hours. The feathers neutralized with sodium hydroxide are desalted, spray-dried and powdered.

As a raw material of the "collagen protein", a collagen protein prepared from bones, skins, muscles and the like of animals such as pigs, cows, chickens and fishes can be used. Production methods include acid, alkali, yeast fermentation and enzymes. Directly or by decomposition by a bioreactor method. For example, it can be manufactured as follows.

After washing the pig skin tissue with water, purified water is added thereto, and the product is decomposed with an enzyme, purified, and powdered by spray drying.

[0028] In addition, Japanese radish, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca, Kombu,
Various plant extracts of hijiki, hibamata, wakame, or various protein decomposed products of silk protein, keratin protein, and collagen protein can be dried, concentrated, or diluted according to the dosage form and form of the hair-restoring hair-restoring food or drink to be applied. It should be done and adjusted.

The dioscorea of the present invention, Panax ginseng,
Various plant extracts of Hypericum, Salvia, Bodaiju, Rakanka, Kombu, Hijiki, Hibamata and Wakame can be directly contained in hair-restoring foods and drinks. It differs slightly depending on the type and quality of the dosage form of the food and drink, and the expected degree of action, and is usually 0.001% by weight or more (hereinafter, expressed in%), preferably 0.2 to 20%. If the content is less than 0.001%, the effect cannot be expected sufficiently.

Similarly, the various protein decomposed products of the silk protein, keratin protein and collagen protein of the present invention can be contained in hair-restoring foods and drinks. It varies slightly depending on the type, quality, and expected degree of action of the hair food or drink, and is usually 0.01% or more, preferably 3 to 50%. still,
If the content is less than 0.01%, the effect cannot be expected sufficiently.

The food / beverage product for hair restoration according to the present invention may optionally comprise, in addition to the above-mentioned essential components, any of the following components and additives within the range not impairing the effects of the present invention.
It can be manufactured in combination.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )etc.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oil Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil and lanolin fatty acid, isononanoic acid, caproic acid And synthetic fatty acids such as 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopiranol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, and phytosterol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or an ester thereof, trehalose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) to which an alkylene (C2-C4) oxide such as ethylene oxide is added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Or amino acid derivatives such as pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. You can choose to serve.

The solvent to be used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, and the like. ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application,
Only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in any mixed solution with water, or may be extracted and extracted.

In foods and drinks, nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and other healthy and cosmetic effects, improvement in taste, provision of color tone, aroma, gloss, stabilization, etc. It can be used for purposes such as thickening and preservation. Furthermore, in addition to this, we expect various cosmetic and pharmacological effects of each raw material known so far, and aim to increase the intended effect by combining them,
Alternatively, it is possible to provide a product that is expected to have a multifunctional effect.

As a specific plant (crude) used as a raw material,
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsujirafuji (Kibo), Acacia, Akasho (Akasho), Akasuri `` Fruit '', Red clover, Red grape, Akaminoki (Logwood), Red acacia (Red bud), Akane (Akane grass root), Red acacia or Jio ( Ground yellow), Agi (Awei), Aki Larch, Akinire (Latinaceae),
Aguay Guacu, Aguahe (Omitengu palm),
Akebi (Kidori), Asa (John Asako), Malva Asagao or Asagao (Toshibushi), Hydrangea (hydrangea), Ashitaba (Ashitaba),
Azuki (red azuki), acerola, asenyaku (Asenyaku), acira (shokuyoukanna), anise, abiu, abiurana, rape, avemaki `` fruit '', avocado, ama, amacha (sweet tea), amachaworu, amadocoro (tamatake), Amana (Kikomiko), Amaranthus (Amaranthus), Amaranthus hippochondriacus, Haribiyu, Amaranthus hippochondriax, Amigasa lily or Bimo (shellfish),
Aristolomeria (Yurizisen), Arcana (Alcanna), Algarrobo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Souduq), Aloe (Length), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azusa), Yellow sapote , Ikakozorina (ground bile head), Epimedium or Epimedium
(Inyokaku), Igusa (Wicked grass), Knotweed (Tiger root),
Strawberry (first place), strawberry, fig (Fig.
Leaf)), Ichihatsu (first time), Ichibi (Fruit Aoi), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimemegi (Enshi), Carob, Inu-zuna (Telelexi), Inubeyu (Sorainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwatsuchi-chi), iwahiba or iwamatsu (makikashiwa), oolong tea, wikyo (fenka), wheat (tibusanoki), ukiyagara (miyoko) ), Uguisukagura "fruit",
Himeuikyo, turmeric (Utsukin), duckweed (buoying), Usubasaishin or Keirinsaishin or Shousaisaishin (spicy), Usvenia oi, Usvenitai oi, Utsubogusa (summer dry grass), Udo or Shishiudo (Qangji, Independent, Tang Independent) ), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Urajirogashi, Uwaurushi (Kusakokomomo), Unshu mandarin (Chen skin), Estragon, Ezocogi (Ezogoka), Echinashi (Hosobamurasakikirengiku) , Enishida, Enokitake (Enokitake), Ebisugusa or Cassia Tora (Keiko), Elcampre, Elderberry `` fruit '', Elemi, Elingy or Prelotus elinge, Endu (Gossip, Sophoraceae rice), Ogi or Kibananagi (yellow) Hoki), Ousei (Naruko lily, Kagi Kurumabanarukoyuri), OuHisasa Yuki or Sasanoyuki, Coptis (Coptis), Oogatahouken, giant Karasuuri (Karokon), Ooguruma (civil engineering incense), giant Tsudzurafuji
(Self defense), psyllium (vegetative child, vegetative grass), toucan hazel (haruko), toucan cactus, pygmy plant or okera
(White jujube), giant leaf sedge (banaba), giant leaf beetle "fruit", giant squirrel (grain sperm), giant caterpillar, giant hawthorn or hawthorn (yamashiko), barley
(Barley), oka, okazeri (snake bed), okra `` fruit '', oguruma (turnover), odorikosou (intermittent), onamimomi (blue ears), onigurumi, onidokoro or tokoro or nagadokoro (hikai), oninoyagara (Tianma) ), Oni lily or Sasasa lily or Hakata lily (Yuri), Ononis, Halibut (Hariha Yu), Ominaeshi (Loose sauce), Oyuco, Dutch mustard (Cresson), Dutch jelly, Dutch honeysuckle, Olive `` Fruits, seeds, leaves '', oregano , Orange "fruit, pericarp", calyxio (ripe yellow), cacao "fruit, pericarp,
Seeds '', oysters (persimmons `` leaves ''), kagi kazura (crop hooks), oysters or kantosou (rensensou), gaku hydrangea, cassia, casino ki (crocodile fruit `` fruits ''), gajutsu (shadotsutsu), Kashiwa
(Sakura tree, Sakhalin), Kascarilla, Kascara sagrada, Gypsophila, Kasensou, Kanixa (Kinosato), Kaniwa, Carnation, Kanokoso (Yoshikone), Birch or Shidare kamba (White birch), Gerbera, Pumpkin, Capoknoki `` Seeds '', Kahoku Sansho (shopper), Gama (bamboo), Chamomile or Roman chamomile, Camellia japonica (weed), Camu cam (camouflage), color, Karaku Sakeman, Ragwort or Chinese Ragwort (Our melon), Ragwishak (midsummer), Ragwort, Guarana `` Seeds '', Karaho (thick), Karaya, Galu, Karin (Gourd melon), Garcinia, Kawamidori, Kawara Psycho (Seiryuna, Hakubaku), Kawazusha, Kawatake, Kawaranadeshiko (Ishitake) or Ezokawaranadeshiko ), Japanese carrot (Aoko), Japanese sagebrush (Inchinko), Kansui (Kansu), Licorice Kantarasa, Candelilla, Kanto, Canna, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiroi strawberry, Maple strawberry, European strawberry), Kiwi `` Fruits, leaves '', Kiwiasuuri (Uroro root), Kikyo (Kikyo, Kikyo root), Kiku (Kikyo) Chrysanthemum flower, oak daisies, daffodils, kikutani daisies, catalpa (Azumizumi), daisies (sheep-of-ears), pheasants (kokomi), kizuta, kidachi aloe, lucky mint, quina, linden (cincona, red linden), quinoa (quinoa), cinnamon (yellow) ), Gymnema Sylvester,
Kimimaku, cabbage, cabbage `` immature fruit '', cucumber, gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja saponaria, Kiraya, Kyransou (gold acne grass), Kumquat `` fruit '', Ginkai, Kimbusen, Kinma, Kinmizukiki
(Sengaku grass), guapeba vermelilla, guava `` fruit '', guayule, quelux infectria (gallicate), kukui nuts, wolfberry (glygi, gugiko, gugi leaf, skeletal bark), kusagi-kazura (tenmon winter), kuzu (kuzukane) ), Camphor tree, gooseberry `` fruit '', ginseng, yellowtail, gardenia, gardenia, blackberry,
Kupuas, Kumazasa, Kumatsuzura (horse whipweed), Clara (bitter butter), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit / leaf", buckthorn, black stalk
(Rescue), cloves (cloves, cloves), gumbinazuna (sekimei, sekimeishi), kaigai (thorns, thorns), celosia (cow flowers, rooster), gekkavidin,
(Laurel), Kenashi Sarutibara (Tokubukuryo, Yamakiko), Gentiana, Gennoshoko (Old Gozo), Kemponashi (Kigushi), Koukisekoku, Kishumican (Koji, Tachibana, Obenimikan, Hukuremican, Sagamikouji, Ponkan, Santara) ), Koushinbara (Monthly flower), Kosui mint, Kozo `` Fruit '', Koucha (tea), Kouhone (Raw bone), Kouhon (Straw book, Karawara book), Koulyang, Kourikyo (Korajang), Koendro `` Fruit '', Kouren (Kohren), Scutellaria (Yellow Gon), Cowberry (Koshibachi),
Coconut "fruit", Goshuyu (goshuyu), Goshoichigo
(Covered bonko), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (spicy), burdock (burdock, burdock), kobotdur, sesame (sesame), sesame clover (gensan), Gomi (Gomiko), Sanekazura or Binankazura or Matsubusa, Wheat (wheat), Rice or rice bran `` red bran, white bran '', rice oil, Cola acuminata `` seed '', cola vera `` seed '', colony lya, fenugreek `` fruit '', Colombo, Kondulango, Konjac, Comfrey (finnari grass), Sisal (Sisal Asa), Sakisima button or Sina button or Sesame
(Sacred Spirits), Sakura (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura,
Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranate, sassa, sasanqua, sagemodaka (sawashatsu), sweet potato, sugarcane, sugar beet, saccharomyces ), Saffron (red safflower, western safflower), sapodilla, sapotea marillo, pomelo "fruit", saponso, salmon berry "fruit", salicinosa
(Somasa), Sawagikyo (Yamakona), Sawagumi (Yamato),
Sankaku cactus, Sangre degrad (croton), Sansouyousou, Sanshin ginseng (San carrot), Sanshuyu (sanshuyu), Sansho (sansho), Sandzukon (Yamazone), Shea (Karite), Cyano (fruit) , Shiitake mushrooms (shiitake mushrooms), zion mushrooms, shiki mushrooms
Perilla or Aodiso or Chirimendiso or Catamediso
(Shiyo leaves, Shiso), rosewood, linden, Chinese pine,
Chinese forsythia (forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, oshiroyishimeji, bunashimeji, honjimesi, shirotamogitake), shimokren (spicy), shimotsukesou, potato, peony (peony), shajin
(Samsin), Jasmine (Matsurika), Janohige (Motomon winter), Gypsophila paniculata, Skushamitsu (Sandin, Compact sand), Juzudama, Palm "fruit", Ginger (Ginger),
Jouzan hydrangea (Tsuneyama), Shobu (iris, iris root),
Shozuku "fruit", Shirakashi "seed", Shirogoshi "seed", white clover (clover), white adzuki bean
(Chicken Bone Grass), Shirobanairis (Small iris), Shirobanatsuta "Flower", Shirominanten (Minami Tenmi), Cinchonasakusylbra, Jinchoge (Mizuka, Mizuka, Shencho), Cinnamon, Cinnammum Cassia (cinnamon), Watermelon ( watermelon),
Honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acid pattern), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', suzu psycho (successor lord), horsetail (question), suberhide (horse ken, horse teeth kenko) ), Plum `` fruit '', Pinus densiflora `` cones '', larch, larch, walnuts, hawthorn, dandelion, European horse chestnut (malonie), pear `` fruits '', snow pear, elder) Atlantic shrews (juniper, juniper), Yarrow (milfoil), Atlantic rose, Atlantic cornflower, Atlantic mistletoe, Atlantic mint or Atlantic mint, Atlantic horseradish, Sekisho (stone iris), Sekkoku (stone stone), sedronk
Mallow, hirohasenega, senega, seri, celery, senkyu (river kyu), senshinren (shinshinren), sendan, sennin cactus, senna `` fruits and leaves '', senninsou (large tate), senburi (drug), souka (grass) Fruit), elephant, buckwheat, buckwheat "seed",
Rhubarb (daihuang), radish, soybean, daidai (orange skin, kikomi),
Takasaburo (Dried lotus grass), Takatodai (Daihoku), Takawarabi (Inu), Dark sweet cherry "fruit", Tachiaoi, Tachijakosou (thyme, Momoka), Tachidokoro
(Hikai), Twill willow, tamarind `` seed '', onion, tamashiba (spicy), taro tree `` fruit, leaf, root bark '', dahlia (tenjikubotan), tarui, tanshiuchiwa, tanjin (dansan), dandelion (gakkou) or white dandelion Or moko dandelion, dammar, cherry `` fruit '', chiyaya `` fruit, root, bud '', chikusetsu carrot (bamboo ginseng), chicory, chancapiedra (Kidachikomikansou), Korean blossom (Ohaku), Korean cinnamon (Buiyi), Artemisia (Aiba), Choreimaitake (Irei), Chorogi,
Tsukimiso, Tsukuritake (mushroom), Camellia, Camellia, Tsumekusa (lacquer lacustrine), Tsumukusa (duckling grass), Tsuruazuki (red azuki bean), Tsurukudami (Hanshukara), Tsuruna (Banju),
Carrot (four-leaf ginseng), camellia, daico, teuchigurumi, duberry `` fruit '', tulip, chocolate nose, tengusa, tencha (tencha), tendai-yaku (wakayaku), touga (winter gourd), toukagizuka, pepper (bansho) , Touki (Toki), Tokinsenka (Marigold), Tounabena (River cut), Maize or Maize hair (Nanbaru hair), Toad Moe (Female Sadako), Toudodo or Korean gooseberry (Ryubile), Tokusa (pirate), Dokudami (jujutsu), radish (root sprout), red pepper or beetle or stag beetle, eucommia (tochu `` bark, leaves, roots ''), ash (qin bark), tomato, tragacanth, triacanthos `` seed '', turkey, tormentilla, dronoki , Trollo mallow, Niseria berry `` fruit '', potato or yam (herbal medicine), Room), elsholtzia ciliata, shepherd's purse, rape, sword bean or Tatehaki (Katanamame), natsudaidai, jujube (Dainatsume), Naniwaibara
(Kanekurako), Navena (intermittent), Nameko, Narco lily (Yoshimi),
Peanut (peanut), Nanten (Minami Tenmi), Namban Karamushi (ramie), Niois violet, Nigaki (Makiki), Nigamogi (Grasshopper), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabnikkei (Chicago) or Keishi (Katsushige) ), Chinese chive
(Niriko), elderberry (bone-bearing tree `` fruit, flower, stem, leaf ''), garlic (garlic), nurde (five times), leek, nemoki or neb or nebi or nemuriki or digokbana (health), thistle (Oji) , Noibara (real fruit), Nozenkazura (Ryoshohana),
Lacewing, Yarrow, Sawdust (Maehu), Nobara, Nomomo, Pineapple `` Fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hirindou,
Hauchiwa, Pau Doce, Hakamauraboshi (bone crushing supplement), Hakusen (ringworm skin), Huckleberry `` fruit '', Hakobe (proliferation), hazel (Haruko), Hashiridekoro (roto root), basil, lotus (lotus, lotus, (Renko), parsley (Netherlands jelly), naked mussels, batata, bees or medakes (bamboo-boiled), patchouli, mint (lightly loaded, lightly loaded leaves), barley (yokuinin), hanasuge (chimochimo), banana, hana mint, hanabishi (swordfish, Shititsuri), vanilla bins, papaya, japonicus
(Mouse malt grass), pahalobobo, hub `` whole plant, stem, leaf '', paprika, hamago or honeysuckle
(Katsuki), Hamabishi (Ritsuko Riko), Hamanas (Maikai flower), Hamabofu (Hama Wind), Hamamelis, Palm, Rose (Roses), Ballata, Balata gum tree, Agarita mushroom (Haratake mushroom, Shilo Oharatake mushroom, Uskirinokasa), Haran, Paliurus ( (Prunus avium), Parietalia,
Balsamina (Tsurureishi, Nigari), Harunile (Yellow, Yuhakuh, Yuba), Barbasco, Harindou, Handaikai (Greaper Sea), Breadfruit, Hiougi (shadow), Lycopodium ginseng (partisan), Pecan nut, Lycopodium (stone) Hirugaru, Torushasha, Higurumadaria, Hishi (Hisami), Pistachio, Beet, Hitotsuba (Stone reed), Hitotsubeniida, Daisies (Daisy), Hinata Kozuchi (cow knees), Hinoki,
Hiba, Castor, Sunflower, Bell Pepper, Himeuzu
Himegama (Kaba), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta "Fruit", Juniper, Biacucu, Hiyu "Fruit", Below-Oy, Hiro-ohinagusa
(Shiratoo), loquat `` fruits, leaves, stems '', betel nut (large clothing skin,
Betel nut, Pu'er tea (Pu-cha), Sperm kazura (Southern rattan), Japanese butterbur, Butterfly dandelion (Apricot winter flower, Azalea winter leaf), Fujiba kama (Orchid grass), Fuji bean (Flax bean), Fujimodoki (Jojizakura, Tochihana), grape "fruit" , Peel, seeds, leaves ", beech,
Fumushinatsukutake mushroom (Cordyceps), Brazilian Licorice,
Brazilian carrots, black currant "fruit", blackberries, blanin, plum "fruits", flucellaria, blueberries (Prunus avium), prunes,
Floral Blanka, Blonde Psyllium, Bundou
(Mung bean), hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '', persair, perbianberg, pereschia grandifolia, benjasou or duckweed (Keiten), boysenberry `` fruit '', pear or elmwort or Nedou or Hawakigi Kokia (skin), Balsam (Fozen, acute offspring, osteophyte), potteria sapota, potteria lukuma, spinach, boufu (windbreak), spinach, physalis (Torone), honoki (wakatsu) (Park, Park), Bokeh (Gourd), Hosoba Aburagiku (Bitter Yoku), Hosoba Ogura, Hosovanaokera (Aoijutsu), Hosobanokirinsou (Kageten Sanshichi), Hosobabarengiku, Button (peony `` flower, leaf, stem, bark ''), Buttonpi (peony skin), hop, jojoba, borage (ruriichisha), Bordeaux, white berry `` fruit '', Hongoniku ( Meat Ji Ryo, Daigei), Hongseokgok (Steel Stone Stone, Sparrow Mountain Stone Masu), Meisulten Nanshaw (Tennan Star), Maitake (Maitake), Maoh
(Mao), maca, macadamia nuts, margaret (mokshungiku), macri (sea grass), maguwa (mulberry white bark `` bark,
Leaf)), Magnolia splengheri, Masalampuba,
Masalan Zuba de Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Kyuukonkinrenka), Matatabi (Kiten Tate), Matsukasa, Pine `` leaves, bark,
Roots, Matta Oryo, Matsuhodo (Bukuryo), Matico
(Cordon sillo), mayolam (Hanaminka), malvanojadine (bitter), mulberry `` fruit '', quince, malein (beloyd mousse), mango, mangosteen,
Mansagna (Andesukamitsure), Mansugurumi,
Mandarin `` Fruit '', Mannentake (Lingzhi), Pheasant (Kikomi `` Fruit ''), Mishima Psycho (Saiko), Mizuobako or Mizuasagao (Ryungoshi), Mizokaku (Hanbe Lotus), Misohagi
(Chikuna), beet willow or elder willow (edition), honeywort, honeywort, midori sapote, green peppermint, mimosa, mioga, miracle fruit `` fruit '', myrrh, mirobaran, oak, oak, oak
(Extended skin), munya, purple (purple root), purple or purple purple pearl, purple maize,
Murasaki Natsuji (Kunming chicken blood wisteria), Megakanza opuntica, Mehajiki (mother mother grass), Mebogi, Melaleuca, Melissa, Melilot, Melon `` Fruit '', Mokoyomigi, Mosobuchikku, Mokkillin, Moje (Kyoboku), Mokko (Mokuko), Maple Butterfly, Peach (peach `` leaves, seeds,
`` Flowers, fruits ''), sprouts, morello cherries `` fruits '', moroheiya (burlap), yakawamurasakiimo, yakuchi (masuti), cornflower (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or giant yashabashi Fruits, peels, and ears "
(Octagonal gold plate), mistletoe (parasitic willow), willow (river willow,
Twill willow, weeping willow, red eye willow, pussy willow, dog koreanagi, kinuyanagi, kolyanagi, unryuyanagi, yamayanagi, coconut palm, yamayanagi, obanyanagi, tyrikkinyanagi, foxeye willow, foxwort, bonsai
(Purple gold beef), tobacco (crane squirrel, Tennasei), pokeweed (commercial land), yamanoki (yamaharu), yamamomo (yang plum skin), sagebrush, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu Fruits, Lily, Yogurusa, Artemisia (Aiba), Lygan (Rainuma), Lime `` Fruit '', Rye, Raspberry `` Leaf, Fruit '', Latania (Clameria),
Rakkyo or shallot (scallop), lavender, longan (longan flesh), agave (Aon agave, fukurin agave), ryocha (green tea), apple `` fruits, seeds, leaves, roots '', gentian, rubus or subavisimus (sweeten), reishi (Lichi, lichi nucleus), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (serial forsythia), astragalus, waxy bean, wax palm, rocon (reed, Root), Loganberry "fruit", rosemary (mannan wax), rose hip (Novara), wasabi, cottonweed (Mengmenhua), waremokou (chiyu) and the like.

Further, other seawaters, for example, seawater salt, seawater dried matter, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic or Pacific Ocean, sea mud or mud (fango) , For example, sea mud or mud of various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide , Calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic,
Wed), Shotoku stone etc.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaa nori, Sugiao nori, Hiraa nori, Bow aonori, Hosoeda aonori), Ana ao algae [Ao aa alga] Species: Giant kelp (Macroscystis pilifera, Macrocystis integrifolia, Neocitys luetokeana), Umiuchiwa, Usubaumiuchiwa, Kilevanoumichuwa, Akabaumiuchiwa, Konauumiuchiwa, Okinawauchiwa, Usuyukiuchiwa, Echikawaumiwa Red algae: Hijirimen, Maxa (Tengusa), Nettle, Onyxa, Obakusa, Cathawk, Yatabegusa,
Yuukiri, Shimanegusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Juniperus giraffe, Tsunomata, Obatsunomata, Tochaka (Yahatsutsunomata), Ezotsunomata, Togetunomata, Hirakotonogi, Kotojinonotashita, Kotojinonotashita
Suzius Banori, Hyus Banori, Akamomininori] and the like.

Other algae such as green algae (Chlamydomonas spp .: Chlamydomonas, Akayukimo, Dunaliella spp .: Dunaliella, Chlorococcus spp .: Chlorococcus, Kwanomimo spp .: Kwanomimo spp., Volvox spp. Spirogyra: Hizaori, Spirogyra, Tsurugimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: medusa, asiaticum gutta, kawashiogusa, marimo, baronia: tamagobaronia, tamabaronia, tamagata: tamagatamo, iwata: husaiwata, surichogita, heraiwata, kurokita, kurokita, kurokita Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, Genus Genus, Genus Colecaetus, Genus genus Tsutsumo, Artemisia spp .: Artemisia spp.

Cyanobacteria (Genus L .: L., L., L .;
(Hassay, genus genus, genus racenmo (spirulina): spirulina, genus trichodesmium (aiakacio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp.
Genus Isogawara: Isogawara, Kuroshira Genus: Gunsenkurogashira, Kashirazaki Genus: Kashirazaki, Muchimo Genus: Muchimo, Hiramutimo, Kebelligsa, Amidixa Genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukurinamiji, Common Genus Artemisia spp.
Genus genus: genus pine, genus genus: genus genus: genus genus, genus okinawa, genus okinawazuku, genus phlebosum, genus phlebosum, genus phlebosum: genus futomozuku, genus genus moss: genus genus: genus kuromo, genus moss, genus genus Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula serrata, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakusugusa: Sharks
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Genus: Genus Genus: Genus Ligustrum, Genus Tsurumo: Genus Tursur, Genus Lana: Aname, Genus Liliaceae: Szyme, Genus Missiscombe: Genus Missiscoma, Genus L., Trolocomb Genus: Antokume, swordfish
Black scallop, Aster genus: Aster sorghum, Nesire scomb: Nestle scomb, Black ssp.
Ainuwakame: Ainuwakame, Tigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Joromoku: Uganomok, Jiromoku, Hiemiku, Hondawara: Tamanashimokku, Imomoku, Red-eye
Hondawara, Nejimoku, Narasamo, Mamewara, Tatsukuri, Yasumatamoku, Umiranoo, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Sawglymoku, Obanokogirimo, Sugimoku, Omoguma, Genus: .

Red algae (Russula genus: Rush genus, Funorinoshiki, Amanori genus: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acer genus, Acer genus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattles: rattle, rattle rattle, hirohatamatamaki genus: hirohatamaitadaki, tamamaidaki genus: tamaitadaki, kagikenori genus: kaginori, kakenenori, tengusa: himetenugosa, haitenugosa, haitenugosa, haitenugusaugou, haitenuganugou, haitenuganugou, haitenugusaugou Genus: hibiroudo, himehibiroudo,
Genus Isommedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekususa: Genus Nisekaregusa, Okitsubara: Obaokitsubara, Akaba: Akaba, Malvaacaba, Naminohana genus
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: ezukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, mosquito mosquito , Tambanori, slippery,
Genus Isonohana: Nuracusa, Cronulla, Stinging genus, Hirakintoki: Hirakintoki, Matagawa: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aedes pine, Kakraitus: Genus Odonata, Genus Larva Genus Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa: Kalexigusa, Tosakamomoki: Hosobanotokamodoki, Hirohanotosakamakiki, Yatsudegatomodoka, Kurosakacamodoki, Nezashinodoka, Nezashinotokada : Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honooka: Hounoo, Hikagenoito: Hikagenoito, Usuginu, Nikuhono: Nikuho Noo, Benisunago genera: Benisunago, Susukakebeni genera: Susukakebeni, Okamuragusa genera:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagiibanodan, Kijinotho genus Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Tengusamodoki: Hachijotengusamodoki, Fushikrenori: Fushikenori, Namiiwatake: Namiiwatake, Spiraea:
Sponge and genus: ssp.
Genus: crocodile, crocodile, crocodile, lotus spp .: lotus spp. The genus Taogosou: Taoyanagisou, Hanasakura, Shirotsunagi: Skullconi, Shikokonori, Hananoeda: Hanaeda, Hiratagoat: Hiratagoat, Darusu: Dars, Masagoshibari, Anadars, Weedbugsa: Uebaguni, Benifukunori
Species of sarcophagi: sarcophagia, scorpion, scorpion, scorpion genus: syllabus, smelt, ssp. Family: Habutaenori, Konohanori, Suzushironori, Usbeni genus: Usbeni, Hasuginu: Hasujiginu, Nagakonohanori: Nagakonohanori, Suzuginu: Suzuginu, Abasibaginu, Hyusbanori: Kagusubanori, Jauresubanoli, Jaureusubanoli, Jaureusubanori, Jaureusubanoli
Genus Ayanishi: Genus Ayanishi, Genus Ayaginu: Genus Ayaginu, Genus Dassia: Enashidazia, Genus Shimadagi: Genus Isohagi, Genus Shimadada, Genus Dazimodoki: Genus Dazimomodoki, Genus Itogusa: Moletogusa, Genus Genus: Makuri, Yanagina, Hana, Rana Salix var. Genus Isomegusa: Isomegusa, Suginashigusa: Suginashigusa, Isobashi Genus: Isobashi, Fujimatsumo: Fujimatsumo, Sawweed: Mushroom Rihiba, Kawamozuku genera: Kawamozuku, Aokawamozuku, Himekawamozuku, Ideyukogome genera: Ideyukogome, Okichimozuku genera: Okichimozuku,
Genus genus, genus chinorimo: chinorimo, genus thysinori: chisinori).

The axle algae (Charium spp.
Hossiturimo: Hossiturimo, Lichnotumnus, Flassula: Himegrass, Chaboflas, Tripella, etc., Yellow algae (Hikarimo: Hikarimo, etc.) and the like.

Materials derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow extract from the stomach, duodenum, or intestine or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract, raw milk or skim milk powder Lactic acid fermentation products, trehalose or derivatives thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigment: anhydrous silicic acid, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonic acid salt, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-aminobenzoic acid Derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate,
Methyl salicylate), anthranilic acid derivatives (methyl anthranilate), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin Guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin and the like.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and the like.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate ester magnesium salt, vitamin C glucoside or the like), hydroquinone or a derivative thereof (hydroquinone benzyl ether or the like), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, corn, waremokou, clara, mugwort, Honeysuckle, yellowfin, yellowtail, matsuhodo, adlay, dragonfly, hops, hawthorn, eucalyptus, achillea millefolium, altea, keihi, mankeishi,
Hamamelis, yamaguwa, life-prolonged grass, bellflower, toshishi, spouse, sun-dried, mako, senkyu, dokkatsu, psycho, bohu, hamabou, ogon, peony, peony,
Gennoshoko, kakkon, licorice, five times child, aloe, ginger, safflower, green tea, black tea, asenyaku), etc.

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether)
etc.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odorikosou, Assemble, Touki, Toukensenka, Amacha, Cucumber, Tachikoso, Rosemary,
Parsley) and the like.

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, aluminum potassium sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) etc.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidant Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, propolis, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hamamelis, Clove, Melissa, Birch, Rosemary, Minami Tenji, Agetsu, Ginkgo, Green Tea), etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, sicon extract, age extract, propolis and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or its hydrolyzate, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, potassium lauroyl sarcosine, etc.),
Cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine,
Brilliant Green, Malachite Green, Crystal Violet, Jarmal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin, propolis, etc. .

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Bacillus natto extract, Loofah water, Birch (birch) or Akamatsu sap

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Clara, mulberry leaves, calyx, genoshoko, comfrey, western elderberry, button boll), seaweed extract and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (eg, estrone, estradiol, ethinylestradiol), isoflavones, oxendrones and the like.

(32) Peripheral vascular blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Stimulants Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activators Photosensitizer No. 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate and the like.

(35) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6
etc.

(36) Keratolytic agents resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium silicate, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.

(38) Hair remover strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like;

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonic acid sodium salt, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Fengqiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batuuri essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils and Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes and Colorants Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikasumi Dye, Turmeric Dye, Endu Dye, Krill Dye, Persimmon Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and the like.

(43) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(44) Nutrition enhancer Shell calcined calcium, cyanocorabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.

(45) Dairy products Milk, cheese, fresh cream, butter, margarine, milk powder, whey, condensed milk and the like.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and antiallergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral agents, deodorants / deodorants, bittering agents, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

The dosage form of the food and drink for hair restoration according to the present invention is arbitrary, and may be formulated in the form of ampules, capsules, pills, tablets, powders, granules, solids, liquids, gels, bubbles, creams, and the like. Can be used.

Specifically, for example, it can be used in all kinds of internal preparations (including preparations used for animals), and specifically, ampoules, capsules, pills, tablets, powders, granules, solids , Liquids, gels or air bubbles 1) pharmaceuticals, 2)
Quasi-drugs, 3) foods and drinks (for example, oral compositions such as gum and candy, processed seafood products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese confectionery, raw noodles and yuden noodles) Noodles such as buckwheat, sauce, soy sauce, sauce, sugar, honey, powdered candy, water syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, soy sauce, Processed vegetables and fruits, such as sprinkled or canned and bottled vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey beverages, soft drinks, alcoholic beverages, etc.) And other general foods and drinks such as beauty foods and health foods (improvement of rough skin and improvement of skin quality). Also, topical or systemic external preparations for skin (for example, lotions, emulsions, creams, ointments,
Oils, soaps, facial cleansers, foundations, lipsticks, blushers, eye shadows, mascaras, perfumes, cataplasms, plasters) and external preparations for the scalp and hair (eg, shampoos, rinses, treatments, hair styling, hair tonics) , Hair growth and hair growth), bath preparations and the like.

The method of addition to the hair-restoring hair food or drink of the present invention may be added in advance or during the production, and may be appropriately selected in consideration of workability.

[0092]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and prescription examples, but the present invention is not limited thereto.

(Manufacturing Example 1) Japanese radish, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca,
100 g of each dried plant of kelp, hijiki, hibamata and wakame is extracted by heating with purified water (about 80 ° C.) for about 5 hours, filtered, and the filtrate is dried under reduced pressure to obtain an extracted powder of about 1 to 3 g.
get g.

(Production Example 2) Japanese radish, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca,
100 g of each dried plant of kelp, hijiki, hibamata and wakame are each extracted by heating with purified water (about 80 ° C.) for about 5 hours, and filtered to obtain an extract (dry solid content: 0.2 to 3.0%). 0.
08-3.0g is obtained.

(Production Example 3) Silk protein hydrolyzate was silk (100 g).
Is first heated to at least 80 ° C. and sterilized by heating. This is heated and dissolved in a high-concentration salt solution of lithium bromide, magnesium nitrate, and calcium chloride, then desalted by dialysis, reverse osmosis, etc., and then reacted with a protease. As the proteolytic enzyme to be used, trypsin was added at a temperature of 37 ° C., 1 part to 40 parts of silk.
Operate under the condition of H7.0. At that time, it is aseptically decomposed for 24 hours. Thereafter, the temperature is raised to 80 ° C. or higher to deactivate the enzyme, followed by centrifugation and removal of the precipitate to obtain a decomposed product derived from the silk protein. This is spray dried to obtain about 10 to 30 g of powder.

(Production Example 4) Keratin protein hydrolyzate was prepared by adding 100 L of hydrochloric acid to 100 g of feathers, treating at 100 ° C. for 15 hours, neutralizing with sodium hydroxide, desalting, spray-drying, and powdering. From about 10 to 30 g.

(Production Example 5) Collagen protein hydrolyzate was
After washing the pig skin tissue (100 g) with water, purified water is added and the one treated with the enzyme bromelain is purified, heated to 80 ° C. or higher and sterilized by heating. Thereafter, the resultant is purified, filtered and spray-dried to obtain about 10 to 30 g of powder. You.

(Test 1) C3H mouse hair growth promotion test Approximately 8 cm ² of the back of the animal was shaved with an electric clipper and an electric shaver. Next, a sample of 20 m per day was taken from the animal whose hair had been removed.
The feedwater was adjusted to g / kg. In addition, the sample was given freely. Judgment was performed on the 20th and 26th days after sample ingestion, using an image analyzer to measure the area ratio (%) at which hair regeneration was observed relative to the depilated area, and the control group without any sample ingestion. Compared. The results are shown in Tables 1 and 2. “Ogawa et al.'S test method (Flexibility Journal, Vol. 17, No. 5, P. 20-29
(1989) ''

(Test Method) a. Sample The various plant extract powders of Production Example 1, the various plant extract powders of Production Example 1, the silk protein degradation product of Production Example 3, the keratin protein degradation product of Production Example 4, and the collagen protein degradation product of Production Example 5 were used alone and each. A sample obtained by mixing equal amounts of the above samples was dissolved in purified water and adjusted to 20 mg / kg / day for use in the test. b. Experimental animals 8-week-old male C3H mice were used. These animals are at room temperature
22 ± 2 ℃, humidity 50 ± 15%, all fresh ventilation 15 times /
The animals were bred in a 9 hour / day lighting environment. Animals had free access to solid feed MF (Oriental Yeast Industry) and tap water.

[0100]

<Table 2>

(Test Results) As shown in Tables 1 and 2, the plant extracts of the present invention, E. ginseng, Panax ginseng, Hypericum perforatum, Salvia, Bodaige, Lacanca, Kombu, Hijiki, Hibamata, Wakame,
A combination of at least one plant extract selected from Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Rakanka, Kombu, Hijiki, Hibamata, Wakame, and at least one protein digest selected from silk protein, keratin protein, and collagen protein As compared with the control group (no addition), hair regeneration was significantly recognized, and it was confirmed that it could be used as a hair growth and hair restoration agent for food and drink.

(Test 2) Safety Test (1) Single Dose Toxicity Test Various plant extracts and various protein degradation products obtained in Production Examples 1 to 5 were adjusted with purified water to a concentration of 12.5%. A dose of 16 mL / kg per animal was orally administered to ddy mice (male and female, 5 animals per group, 5 weeks old) which had been fasted for 4 hours before the test, and the occurrence and degree of toxic symptoms were evaluated with time. Observed. As a result, no abnormality was observed in all the mice for 14 days, and no abnormalities were found in the dissection results. Therefore, LD50 is 2,00
It was 0 mg / kg or more, so it was judged as a safe substance.

(Prescription Example) Production of Hair-Fostering Food and Beverage In accordance with the above evaluation results, the following prescription examples are shown. Only shown. Further, the present invention is not limited to these.

(Prescription Example 1) Mentsuyu Solution (Weight%) 1. Soy sauce 80.0 2. Black vinegar 2.0 3. Glucose 13.0 4. Sodium glutamate 2.0 5. Extracted powder of E. ginseng 1.5 of Production Example 1

(Formulation Example 2) Udon or buckwheat weight% 1. Flour or buckwheat flour 90.0 2. Salt 1.0 3. Powder of St. John's wort extracted from Production Example 1 4. Powdered silk protein hydrolyzate from Production Example 3 4.0 5. Roman chamomile Extracted powder 1.0

(Prescription Example 3) Beverage weight% 1. Glucose liquid sugar 30.0 2. Grapefruit juice 50.0 3. Bodaiju hot water extract (solid content 0.5%) 7.0 4. Lacanca hot water extract (solid content 0.5%) 4.0 5. Keratin protein hydrolyzate powder of Production Example 4 4.0 6. Kiwi extract powder 5.0 7. Appropriate amount of flavoring agent 8. Appropriate amount of acidulant

(Formulation Example 4) Bread weight% 1. Flour 80.0 2. Salt 1.0 3. Glucose 7.0 4. Salvia hot water extract (solid content 0.3%) 4.0 5. Kombu hot water extract (solid content 0.3%) 4.0 6. Collagen protein hydrolyzate powder of Production Example 5 2.0 7. Vitamin E 1.0 8. Heme iron 1.0

(Formulation Example 5) Cookie weight% 1. Milk 61.0 2. Whole egg 20.0 3. Sugar 5.0 4. Constarch 7.0 5. Salt 1.0 6. Panax ginseng water extract (solid content 1.0%) 2.0 7. Hijiki water extraction Extract (solid content 1.0%) 2.0 8. Collagen protein hydrolyzate powder of Production Example 5 1.0 9. Chlorogenic acid 1.0 10. Appropriate amount of flavor

(Formulation Example 6) Sausage weight% 1. Ground meat 80.0 2. Chicken eggs 5.0 3. Spices 1.0 4. Seasonings 1.0 5. Hibamata hot water extract (solid content 0.3%) 4.0 6. Wakame hot water extract ( Solid content 0.5%) 4.0 7. Loquat leaf hot water extract 5.0

(Formulation Example 7) Gum weight% 1. Menthol micron 30.0 2. Grapefruit flavor 60.0 3. Hypericum perfumery extract (solid content 2.0%) 4.0 4. Silk protein hydrolyzate solution (solid content 0.5%) 2.0 5 .Wakame hot water extract (solid content 0.5%) 2.0 6. Tannin 2.0

(Formulation Example 8) Miso soup weight% 1. Tofu 30.0 2. Deep fried 5.0 3. Carrot 5.0 4. Burdock 5.0 5. Red Miso 20.0 6. Salvia hot water extracted powder 4.0 7. Keratin protein hydrolyzate powder 2.0 8. Wakame hot water extract (solid content: 0.5%) 2.0 9.

(Formulation Example 9) Coating protective agent A gauze or liniment cloth is impregnated with a prescription solution prepared by mixing a suitable amount of hot water extract, an antibiotic, an anti-inflammation, etc., and attached to the wound. Alternatively, the Laccanca hot water extract may be directly sprayed locally and covered with gauze or the like.

(Test 3) Use effect test The effect of the hair growth and hair growth agent of the present invention actually used was examined. The test used was a panel of 10 people (25-50 years old) complaining of alopecia and alopecia, and samples (a variety of plant extraction powders of Production Example 1 and various plant extraction powders of Production Example 1) were added to commercially available soft drinks every day. The silk protein hydrolyzate of Production Example 3, the keratin protein hydrolyzate of Production Example 4, and the collagen protein hydrolyzate of Production Example 5 alone and a mixture of equal amounts of each sample were dissolved in purified water, and the concentration was reduced to 20 mg / kg. Adjusted)
Was added and 350 ml of well mixed drinking water was drunk for 6 months. As a control, a commercially available soft drink to which the various plant extracts or various protein degradation products of the present invention were not added was drunk in the same manner. The evaluation was performed according to the following criteria. The results are as shown in Tables 3 to 10, and the numerical values in the table represent the number of persons. No one complained of abnormal physical condition or scalp / hair during the use period.

"Hair-growing / hair-growing effect" Effective: Very large amount of downy hair was produced. Slightly effective: slight downy hair was generated. Ineffective: No change from before use.

[0116]

[0117]

[0118]

[0119]

"Effect of improving hair feel" Efficacy: The gloss, tension, and smoothness of the hair were increased, and combing was very good. Slightly effective: The gloss, tension, and smoothness of the hair were slightly increased, and combing was slightly improved. Ineffective: No change from before use.

[0121]

[0122]

[0123]

[0124]

(Test results) As shown in Tables 3 to 6, the plant extracts of the present invention, E. ginseng, Panax ginseng, Hypericum perforatum, Salvia, Bodaige, Lacanca, Kombu, Hijiki, Hibamata, Wakame, and also E. ginseng,
One or more plant extracts selected from Panax ginseng, St. John's wort, Salvia, Bodaiju, Rakanka, Kombu, Hijiki, Hibamata, Wakame, together with one or more protein degradants selected from silk protein, keratin protein, collagen protein Food and beverages are
A large number of people who had significant downy hair were recognized, and the effect of hair growth and hair growth was confirmed.

(Test Results) As shown in Tables 7 to 10, each of the plant extracts of the present invention, E. ginseng, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca, Kombu, Hijiki, Hibamata and Wakame, and also E. ginseng,
One or more plant extracts selected from Panax ginseng, St. John's wort, Salvia, Bodaiju, Rakanka, Kombu, Hijiki, Hibamata, Wakame, together with one or more protein degradants selected from silk protein, keratin protein, collagen protein Food and beverages are
The hair was given gloss, tension, and smoothness, and the comb was improved, and the effect of improving the hair feel was confirmed.

[0127]

EFFECTS OF THE INVENTION According to the present invention, E. ginseng, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca,
Plant extracts of kelp, hijiki, hibamata, wakame,
In addition, one or more proteins selected from silk proteins, keratin proteins, and collagen proteins together with one or more plant extracts selected from Emmeso, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca, Kombu, Hijiki, Hibamata, Wakame The hair-restoring food or drink containing the decomposition product in combination has an excellent hair growth and hair growth effect, and gives the hair gloss, tension and smoothness, improves comb combability, and improves hair feel. It also has an effect. It is safe for humans and animals.

[Procedure amendment]

[Submission date] February 22, 2001 (2001.2.2)
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0031

[Correction method] Change

[Correction contents]

The food / beverage product for hair restoration according to the present invention may optionally comprise, in addition to the above-mentioned essential components, any of the following components and additives within the range not impairing the effects of the present invention.
It can be manufactured in combination, and the content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 35/78 A61K 35/78 CMZS A61P 17/14 38/17 A61K 7/06 A61P 17/14 A23L 2 / 00F // A61K 7/06 A61K 37/12 F term (reference) 4B017 LC03 LG15 LG18 LK15 LK17 LK21 LK23 LL09 LP01 LP05 LP06 LP18 4B018 MD22 MD54 MD61 MD67 MD68 MD69 ME14 MF01 MF10 MF12 MF13 AA432 AA432A AD441 AD442 AD451 AD452 CC37 DD50 EE06 EE12 EE22 4C084 AA02 BA44 CA17 DA40 DC50 MA52 MA63 NA05 ZA922 4C088 AA13 AA14 AB12 AB18 AB19 AB38 AC03 AC04 AC05 AC06 AC11 AC12 CA05 CA06 CA07 CA14 CA17 MA02 MA08 MA52 MA63 ZA92

Claims (2)

[Claims] 1. A hair-restoring hair-restoring food and drink comprising one or more plant extracts selected from the group consisting of Empire, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca, Kombu, Hijiki, Hibamata and Wakame. 2. A hair-restoring food or drink comprising the following (1) and (2) as essential components. (1) One or more plant extracts selected from Emisoa, Panax ginseng, Hypericum perforatum, Salvia, Bodaiju, Lacanca, Kombu, Hijiki, Hibamata and Wakame. (2) One or more protein degradation products selected from silk proteins, keratin proteins, and collagen proteins.