WO2007083402A1 - Nutritional supplement for promotion of hair growth and/or hair restoration - Google Patents

Nutritional supplement for promotion of hair growth and/or hair restoration Download PDF

Info

Publication number
WO2007083402A1
WO2007083402A1 PCT/JP2006/309539 JP2006309539W WO2007083402A1 WO 2007083402 A1 WO2007083402 A1 WO 2007083402A1 JP 2006309539 W JP2006309539 W JP 2006309539W WO 2007083402 A1 WO2007083402 A1 WO 2007083402A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
hair growth
mass
growth
keratin
Prior art date
Application number
PCT/JP2006/309539
Other languages
French (fr)
Japanese (ja)
Inventor
Yukio Hasebe
Original Assignee
Almado Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almado Co., Ltd. filed Critical Almado Co., Ltd.
Publication of WO2007083402A1 publication Critical patent/WO2007083402A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
    • A61K38/015—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen from keratin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

Definitions

  • the present invention relates to a nutritional supplement for hair growth and / or hair growth (hereinafter, the dietary supplement is referred to as a supplement).
  • the type III collagen necessary for the growth and development of the body is not always produced.
  • both males and females grow up to 145-190cm tall, and the growth of each part is accompanied by the physique. It has the developmental function of each part as a potential of human beings, and that function plays each role.
  • the structure of the first stage of development and growth is maintained to some extent, and the strength of each part of the human body is shifted to work to create a strong and solid body. Body that can endure intense exercise, work ability, social life It is a very important time as a human role, such as the construction of the spirit, the prosperity of offspring, and the work of creating the next generation of life.
  • a single hair consists of a part (hair shaft part) protruding on the skin surface and a part (hair root part) buried in the skin.
  • the hair root is wrapped in a sheath-like follicle.
  • the hair stretches through the hair follicles, exits the skin surface, is pushed out, and continues to grow.
  • the lower part of the hair follicle has a hair ball swelled like an onion.
  • the end of this hair bulb is recessed like a candle flame, and wraps the hair papilla.
  • the hair ball and the hair papilla are shaped like ones.
  • the hair papilla has blood vessels that feed hair matrix cells and plays an important role in hair growth.
  • a hard protein called keratin is made in the hair papilla. As keratin is made more and more, the hair matrix cells grow larger and repeat the division, making the hair to be pushed out and sent out.
  • the hair matrix cells in the hair bulb are active cells among the cells that make up the body, as it is clear that growing hair is visibly growing. In the lower half, it continues to divide and proliferate, and it is gradually pushed up while creating the hair body and root sheath, and begins to differentiate into layers of hair while losing moisture and keratinizing.
  • the cells that make up the hair divide from around the center of the hair bulb, and while taking up the melanin pigment made by the pigment cells that make up the color of the hair, keratinization proceeds and the hair grows.
  • Hair growth does not extend the tip of the hair
  • the nutrients carried by the blood divide the cells at the hair papilla at the root of the hair to make hair, and push it out and stretch it out. is there.
  • the conditions for healthy hair are: (a) the presence of follicles and nipples, (b) good nutrition and good blood circulation, and sufficient amino acid, vitamins and minerals to be sent ( c )
  • protein synthases There are protein synthases, and there is no abnormality in the autonomic nerves and hormones necessary for their function. All of these are necessary for hair health.
  • hair growth is inhibited by one or more of the above hair growth conditions missing or incomplete.
  • nutrition for the growth of hair is derived from the nutrients in the blood, the basic shellfish IJ, and it is important that nutrients that are always balanced are sent abundantly to the hair papilla.
  • proteins, lipids, and sugars act as energy sources that maintain the body and promote hair growth.
  • Proteins and minerals act as constituents of the body and hair, and some of the vitamins and minerals assist in the metabolism of carbohydrates, lipids, and proteins, facilitating metabolism and improving hair quality.
  • the functional components that support healthy growth of hair from the side and smooth the normal functioning of the body the nutritional group that keeps the mind and brain working normally, the deterioration of the environment and chemical contamination Nutrients that protect the living body and hair, etc. Many nutrients are necessary for hair to be generated and grown.
  • the present inventor has focused on the following three points as the most important matters regarding hair growth.
  • the first point is that the protein that is the main component of hair is keratin containing 14 to 18% cystine.
  • proteins are composed of about 20 amino acids.
  • the third point is that keratin is composed of about 18 amino acids.
  • Table 2 shows the composition of 18 kinds of amino acids (content:%) in hair keratin.
  • hair keratin has a ratio of basic amino acids histidine, lysine, and arginine of 1: 3: 10. This ratio is unique to hair keratin and is not found in other proteins. It is known that if there is an imbalance in the amino acid composition of protein due to diet, it will have a serious adverse effect on hair growth.
  • the present inventor is also composed of amino acid and amino acid strength that are insufficient in the living body due to a decrease in production function, and can directly take keratin by eating. Researched and pursued ingredients.
  • the inventor has developed an eggshell membrane that can be digested and absorbed for the first time in Japan.
  • eggshell Membranes are very difficult to digest in the natural state, and if eaten as they are, they become clogged in the digestive tract and become difficult to excrete. Therefore, it was found that the eggshell membrane was made into a nano-powdered eggshell membrane, resulting in a food that can be digested and absorbed.
  • Table 3 shows the amino acid content (%) of eggshell membranes.
  • the eggshell membrane is composed of 18 kinds of amino acids. This composition is very similar to that of human hair.
  • eggshell membranes contain 13 to 18% cystine among 18 types of ingredients. It contains a great deal of natural ingredients.
  • cystine in the eggshell membrane is excellent in the ability to reproduce each part of the human body is as already disclosed in Patent Document 1 by the present inventor. It was found that by eating such eggshell membrane powder, the body's fibroblasts proliferated by their own power, which produced type III collagen. It was also found from many cases that fibroblasts proliferate into hair matrix cells at the same time as type III collagen production.
  • Patent Document 1 JP 2002-29031 A
  • Patent Document 2 Japanese Patent Laid-Open No. 2003-146895
  • the present invention has been made in view of the above points, and the object thereof is to use a more suitable one that promotes or assists the excellent hair growth-hair growth promoting action and hair loss preventing action of eggshell membranes. Therefore, it is intended to provide a supplement that can produce a hair growth / hair growth effect with a low cost and a high probability in a relatively short period of time.
  • the hair growth / hair growth supplement according to the present invention is characterized by containing eggshell membrane powder, hydrolyzed keratin, and yew leaf extract (claim 1).
  • the body's fibroblasts proliferate with its own power, and type III collagen is produced, and at the same time, the fibroblasts proliferate the hair matrix cells.
  • cystine which is abundant in eggshell membranes, has a high ability to regenerate each part of the body, and its ability is high compared to any other food.
  • Keratin is a strong fiber-rich protein made by binding 20 kinds of amino acids, and constitutes most of the substances in cells that form hair. The yew leaf extract effectively delivers eggshell membrane powder and active ingredients of keratin to cells by promoting blood circulation in the body. For this reason, the functions of the scalp and hair are enhanced, and the hair growth effect is further improved, which is remarkably expressed.
  • the eyelashes and eyebrows are also grown, and it has been confirmed that they grow thick and long.
  • the hair growth / hair growth supplement according to the present invention contains vitamins that help digestion and absorption (claim 2).
  • Vitamins such as vitamin B2 help the digestive absorption of eggshell membranes and keratin active ingredients in the body, so that the active ingredients are efficiently used for hair production.
  • the hair growth / hair growth supplement according to the present invention is formed into a capsule dosage form, and about 250 mg is contained in one capsule (claim 3).
  • the most preferred hair growth / hair growth supplement according to the present invention is 22% by mass of eggshell membrane powder, 20% by mass of hydrolyzed keratin, 6% by mass of yew leaf extract, 0.5% by mass of vitamin B2, It is characterized by containing 8% by mass of an antioxidant (Claim 5).
  • the eggshell membrane powder causes the proliferation of the body fibroblasts, the creation of type III collagen, the growth of hair matrix cells from the fibroblasts, and the eggshell membrane has a high cell regeneration.
  • Noh It contains a large amount of cystine, and keratin is a component of hair, and is an effective ingredient of these eggshell membranes and keratin.
  • the functions of the scalp and hair are enhanced.
  • the hair growth-hair growth effect or the effect of preventing hair loss and the promotion effect thereof are remarkably improved, and the effect is remarkably exhibited within a relatively short period of time.
  • the supplement according to the present invention is obtained by adding a leaf extract to the above two main raw materials, ie, eggshell membrane powder and hydrolyzed keratin, in order to promote hair growth. When taken, it extracts blood circulation and has the effect of enhancing the functions of the scalp and hair. Therefore, the hair growth / hair growth effect of the product of the present invention was further improved by adding the yew leaf extract.
  • the product of the present invention further contains vitamins such as vitamin B2.
  • vitamins such as vitamin B2.
  • eggshell membrane powder eggshell membranes that are inherently difficult to digest and absorb can be digested and absorbed as described above, but vitamins help digestive absorption of eggshell membranes and keratin in the body. . Therefore, in the product of the present invention, eggshell membranes and keratin components are used very efficiently for the production of hair.
  • the effective range of the mixing ratio of the eggshell membrane powder is 10 to 50% by mass, and the optimum value is before and after 22% by mass. When it was less than 10%, many monitors used it, and it was found that the effect was weak. If it exceeds 50%, the eggshell membranes are inherently difficult to digest, so digestion is burdened by the stomach and tends to cause indigestion. If it is 50%, adjust the blending ratio of other ingredients to 100% in total.
  • the effective range of the hydrolysis keratin content is 10-30% by mass, and the optimum value is around 20% by mass. If it is less than 10%, the effect is less than 30%. This is not preferable because the balance between digestion problems and other ingredients is lost.
  • the effective range of the ratio of the yew leaf extract is 1 to 15% by mass, and the optimum value is around 6% by mass. If it is less than 1%, the effect is less than 15%, and the balance with other ingredients is lost.
  • the effective range of vitamin content is 0.5 to 10% by mass, and the optimum value is 0.5% by mass. Less than 5% is less effective. If it exceeds 10%, the remaining amount in the body increases, which is unfavorable because it may harm your health. Vitamins are considered to be excreted in excess of the appropriate amount, but excess vitamins are thought to remain in the body, and excessive amounts in the body may harm health. Considering this point, the blending ratio is kept low.
  • the effective range of the antioxidant content is 1 to 10% by mass, and the optimum value is 8% by mass. If it is less than 1%, the effect is insufficient. If it exceeds 10%, the balance with other compounding materials is lost, which is not preferable.
  • the present invention is intended to ensure that each active ingredient exhibits its most effective effect, rather than adding only ingredients that are good for hair growth and hair growth. Is well balanced. The inventor carried out with the belief that this was the most important thing.
  • a No. 2 white capsule-like tablet-shaped hair growth supplement for hair growth having an internal volume of 250 mg was produced.
  • Table 4 shows the raw material names, blending ratio, and content per grain.
  • Keratin powder 2 0. 0 0 5 0. 0 0
  • Vitamin C and vitamin E are used as antioxidants. Vitamin C and vitamin E have a strong antioxidant action, and vitamin E is also called an anti-aging vitamin, and has a blood circulation promoting action and a blood circulation normalizing action. Vitamin B2 promotes growth and keeps the skin healthy.
  • Each raw material shown in Table 4 is dehydrated and dried so that the water content is around 10%. Then, stir and granulate with sufficient care so that all the grains are uniform. Shape into a shape that will not oxidize and make capsules, shellac tablets, granules, or sugar-coated tablets.
  • the product of the present invention No. 2 white capsule-shaped hair growth / hair growth supplement with an internal volume of 250 mg
  • an effect never seen before was achieved. In other words, there are a small amount of short hair that cannot be seen in the shining area.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Botany (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

Disclosed is a low-cost supplement which can exert a high effect of promoting the hair growth/restoring the hair in a relatively short period of time with a high probability. A nutritional supplement for the hair growth promotion/hair restoration comprising 22% by mass of an egg shell membrane powder, 20% by mass of hydrolyzed keratin, 6% by mass of a ginkgo leaf extract, 0.5% by mass of vitamin B2 and 8% by mass of an anti-oxidant.

Description

明 細 書  Specification
発毛及び又は育毛用栄養補助食品  Nutritional supplements for hair growth and / or hair growth
技術分野  Technical field
[0001] 本発明は、発毛及び又は育毛用栄養補助食品（以下、栄養補助食品をサプリメント という。）に関する。  [0001] The present invention relates to a nutritional supplement for hair growth and / or hair growth (hereinafter, the dietary supplement is referred to as a supplement).
背景技術  Background art
[0002] [老化と毛髪との関係]  [0002] [Relationship between aging and hair]
人間は、男女とも 25歳前後から老化が始まる。それは、人間が肉体的な発育と成 長が止まる時期でもある。人間の肉体構造が変化し、子供の成長期から大人の堅固 な体に変化する一つの曲がり角である。  Humans begin aging around age 25 for both men and women. It is also a time when human growth and growth stops. It is a turning point that changes the human body structure and changes from a child's growth period to a solid body of an adult.
その曲がり角では、体の中で何が変化してるのかを検証してみる。  At that corner, we will examine what is changing in the body.
1. 肉体の発育成長に必要な III型コラーゲンを常時、製造しなくなる。  1. The type III collagen necessary for the growth and development of the body is not always produced.
2.そして、人間の表皮、毛髪、体中の全ての臓器、筋肉、骨を成長期から丈夫 (堅 固）なものへと変化させる。従って、人間の体の部位の大部分が強ぐ固くなつていく のが、この 25歳前後なのである。  2. Then, change the human epidermis, hair, and all organs, muscles, and bones in the body from a growing stage to a strong one. Therefore, it is around this 25-year-old that most of the parts of the human body become strong and firm.
3.それは、人間の潜在的機能による、細胞再生機能の低下を意味する。  3. It means a decrease in cell regenerative function due to human potential function.
[0003] 人間の成長段階は、表 1のように、 5期に分けることができる。 [0003] As shown in Table 1, human growth stages can be divided into five stages.
1]  1]
Figure imgf000002_0001
一期の発育成長期には、男女とも身長 145〜190cmまで成長し、その体格に見合 つて、各部位の成長も伴ってくる。それは、人間の生まれながらにして潜在能力として 各部位の発育機能を持ち、その機能がそれぞれの役割を果たす。二期の旺盛期は 、一期の発育成長期の構造をある程度維持しながら、人間の各部位の強さ、丈夫で 堅固な体を作る作業に移行する。激しい運動、作業能力、社会生活に耐えうる肉体 と精神の構築、子孫の繁栄、次世代の生命を生み出す作業など、人間の役割として 非常に大切な時期なのである。 従って、この期では、発育成長期に旺盛であった繊 維芽細胞の再生が不足し、女性であれば、肌の曲がり角として皮膚に一早くその現 象が現れ、肌荒れ、くすみ、乾燥、そして、シミ等のトラブルが発生し易くなる。また、 男性であれば、 30歳前後から毛髪の抜け（抜け毛）が始まり、早くてハグになってしま う。このような現象は、全てが繊維芽細胞の再生不足や構造変化 (機能低下）に起因 している。
Figure imgf000002_0001
In the first development period, both males and females grow up to 145-190cm tall, and the growth of each part is accompanied by the physique. It has the developmental function of each part as a potential of human beings, and that function plays each role. During the second period of growth, the structure of the first stage of development and growth is maintained to some extent, and the strength of each part of the human body is shifted to work to create a strong and solid body. Body that can endure intense exercise, work ability, social life It is a very important time as a human role, such as the construction of the spirit, the prosperity of offspring, and the work of creating the next generation of life. Therefore, during this period, the regeneration of fibroblasts, which has been active for a long period of development, is insufficient, and if it is a woman, the phenomenon appears on the skin as a corner of the skin, causing rough skin, dullness, dryness, and , Troubles such as spots are likely to occur. Also, if you are a man, hair loss (hair loss) will start around 30 years old and you will be hugging at the earliest. All of these phenomena are due to insufficient regeneration of fibroblasts and structural changes (decreased function).
[0005] [毛髪の発育機構] [0005] [Hair development mechanism]
一本の毛髪は、皮膚表面に出た部分（毛幹部）と皮膚の中に埋もれてレ、る部分（毛 根部）とからなる。毛根は鞘状の毛包に包まれている。毛髪はこの毛包の中を伸びて 皮膚表面に出て、外へ外へと押し出されて伸び続ける。毛包の下の部分には、玉ね ぎ状に膨らんだ毛球を有する。この毛球の末端はろうそくの炎形のように凹んで、毛 乳頭を包んでいる。毛球と毛乳頭は嚙み合ったような形になっている。毛乳頭には毛 母細胞を養う血管が分布しており、毛髪の発育に大切な役割を担っている。毛乳頭 でケラチンという固いタンパク質が造られる。ケラチンがどんどん造られると、毛母細 胞は大きく成長し、分裂を繰り返して、押し出すように毛髪を作って送り出すようにな つている。  A single hair consists of a part (hair shaft part) protruding on the skin surface and a part (hair root part) buried in the skin. The hair root is wrapped in a sheath-like follicle. The hair stretches through the hair follicles, exits the skin surface, is pushed out, and continues to grow. The lower part of the hair follicle has a hair ball swelled like an onion. The end of this hair bulb is recessed like a candle flame, and wraps the hair papilla. The hair ball and the hair papilla are shaped like ones. The hair papilla has blood vessels that feed hair matrix cells and plays an important role in hair growth. A hard protein called keratin is made in the hair papilla. As keratin is made more and more, the hair matrix cells grow larger and repeat the division, making the hair to be pushed out and sent out.
成長期にある毛髪が目に見えて成長することから明ら力なように、毛球部の毛母細 胞は、体を作っている細胞の中でも生活力が活発な細胞で、毛球の下側半分の部 分で絶えず分裂、増殖を続け、毛髪本体と毛根鞘を作りながら次第に押し上げられ、 水分を失って角化を行いながら、毛髪の各層への分化が始まる。  The hair matrix cells in the hair bulb are active cells among the cells that make up the body, as it is clear that growing hair is visibly growing. In the lower half, it continues to divide and proliferate, and it is gradually pushed up while creating the hair body and root sheath, and begins to differentiate into layers of hair while losing moisture and keratinizing.
毛髪を作る細胞は、毛球の中心あたりから分裂し、毛の色を作る色素細胞の造った メラニン色素を取り込みながら角化を進めて毛髪を成長させていく。  The cells that make up the hair divide from around the center of the hair bulb, and while taking up the melanin pigment made by the pigment cells that make up the color of the hair, keratinization proceeds and the hair grows.
[0006] [毛髪育成条件] [0006] [Hair growth conditions]
毛髪の成長は、毛先が伸びるのではな 血液が運んでくる栄養分によって毛根部 の毛乳頭で細胞が分裂して毛髪が造られ、外へ外へと押し出されて伸びてレ、くもの である。健康な毛髪が作られる条件は、（a)毛包、毛乳頭が存在すること、 （b)栄養状 態が良好で血行も順調であり、アミノ酸やビタミン、ミネラルが十分に送られること、（c )タンパク合成酵素が存在して、その働きに必要な自律神経やホルモンに異常がな レ、こと、などである。これら全てが毛髪の健康にとっては必要なものである。 Hair growth does not extend the tip of the hair The nutrients carried by the blood divide the cells at the hair papilla at the root of the hair to make hair, and push it out and stretch it out. is there. The conditions for healthy hair are: (a) the presence of follicles and nipples, (b) good nutrition and good blood circulation, and sufficient amino acid, vitamins and minerals to be sent ( c ) There are protein synthases, and there is no abnormality in the autonomic nerves and hormones necessary for their function. All of these are necessary for hair health.
従って、上記毛髪育成条件の一つ又は複数の欠落又は不全により、毛髪の成長が 阻害される。とくに、毛髪の成長のための栄養は、血液中の栄養からとるのが基本原 貝 IJであり、常にバランスがとれた栄養が豊富に毛乳頭に送られることが重要である。  Accordingly, hair growth is inhibited by one or more of the above hair growth conditions missing or incomplete. In particular, nutrition for the growth of hair is derived from the nutrients in the blood, the basic shellfish IJ, and it is important that nutrients that are always balanced are sent abundantly to the hair papilla.
[0007] [毛髪と栄養]  [0007] [Hair and nutrition]
タンパク質、脂質、糖質の一部は、生体を維持し、毛髪の発育を促すエネルギー源 として働く。タンパク質とミネラルは生体及び毛髪の構成物質として働き、ビタミンとミ ネラルの一部は糖質、脂質、タンパク質の代謝を補助して、代謝を円滑にし、毛髪の 質を高める。さらに、毛髪の健全な生成'成長を側面から支え、体内の正常な機能を 円滑にする機能性成分、心と脳'神経の働きを正常に保つ栄養群、環境の悪化や化 学物質汚染から生体と毛髪を護る栄養群等々、毛髪が生成 ·成長してレ、くためには、 多くの栄養素が必要である。  Some of proteins, lipids, and sugars act as energy sources that maintain the body and promote hair growth. Proteins and minerals act as constituents of the body and hair, and some of the vitamins and minerals assist in the metabolism of carbohydrates, lipids, and proteins, facilitating metabolism and improving hair quality. In addition, the functional components that support healthy growth of hair from the side and smooth the normal functioning of the body, the nutritional group that keeps the mind and brain working normally, the deterioration of the environment and chemical contamination Nutrients that protect the living body and hair, etc. Many nutrients are necessary for hair to be generated and grown.
[0008] 本発明者は、以上の毛髪に関する知見の中で、毛髪の発育に関して最も重要な事 項として、次の 3点に着目した。第 1点は、毛髪の主成分であるタンパク質は、シスチ ンを 14〜： 18%含むケラチンであること。第 2点は、タンパク質は、約 20種類のァミノ 酸からなっていること。第 3点は、ケラチンは約 18種類のアミノ酸で構成されているこ と。  [0008] Among the knowledge about the hair described above, the present inventor has focused on the following three points as the most important matters regarding hair growth. The first point is that the protein that is the main component of hair is keratin containing 14 to 18% cystine. Second, proteins are composed of about 20 amino acids. The third point is that keratin is composed of about 18 amino acids.
[0009] 毛髪ケラチンの 18種類のアミノ酸組成 (含有量：％)は表 2に示すとおりである。  [0009] Table 2 shows the composition of 18 kinds of amino acids (content:%) in hair keratin.
[表 2] [Table 2]
アミノ酸 人の毛髪ケラチン Amino acid human hair keratin
リジン 2. 4  Lysine 2.4
ヒスチジン 0. 8  Histidine 0.8
アルギニン 8. 9  Arginine 8.9
トリブトファン 0. 7  Tribute Fan 0.7
ァスパラギン酸 7. 4  Aspartic acid 7.4
スレオニン 6. 7  Threonine 6.7
セリン 7. 1  Serine 7.1
グルタミ ン酸 1 3. 8  Glutamate 1 3. 8
プロリン 3. 4  Proline 3.4
グリシン 8. 8  Glycine 8.8
ァラニン 3. 7  Alanine 3.7
シスチン 1 4. 9  Cystine 1 4. 9
パリン 4. 4  Parin 4.4
メチォニン 0. 9  Methionine 0.9
ィソロイシン 2. 0  Soloy Shin 2.0
σイシン 8. 5  σ Ishin 8.5
チロシン 2. 9  Tyrosine 2. 9
フエ二ルァラニン 2. 5  Felanalanin 2.5
[0010] 表 2から判るように、毛髪ケラチンは、塩基性アミノ酸のヒスチジン、リジン、アルギニ ンの比率が 1 : 3 : 10である。この比率は、毛髪ケラチン特有の比率であり、他のタン ノ ク質には見られなレ、。食事によるタンパク質のアミノ酸組成にアンバランスがある場 合は、毛髪の発育に重大な悪影響が及ぶことは知られている。 [0010] As can be seen from Table 2, hair keratin has a ratio of basic amino acids histidine, lysine, and arginine of 1: 3: 10. This ratio is unique to hair keratin and is not found in other proteins. It is known that if there is an imbalance in the amino acid composition of protein due to diet, it will have a serious adverse effect on hair growth.
[0011] これに基づいて、本発明者は、生成機能低下により生体自体では不足しているアミ ノ酸及びアミノ酸力も構成されてレ、るケラチンを、食することにより直接に摂取すること ができる食材を研究し、追求した。  [0011] Based on this, the present inventor is also composed of amino acid and amino acid strength that are insufficient in the living body due to a decrease in production function, and can directly take keratin by eating. Researched and pursued ingredients.
[0012] 発明者は、 日本で初めて食して消化吸収することができる卵殻膜を開発した。卵殻 膜は、自然状態では、非常に消化できにくい物であり、そのまま食すると、消化器内 で詰まってしまい、排泄が困難になる。そこで、卵殻膜をナノパウダー状の卵殻膜とし た結果、消化吸収可能な食材となることが判明した。 [0012] The inventor has developed an eggshell membrane that can be digested and absorbed for the first time in Japan. eggshell Membranes are very difficult to digest in the natural state, and if eaten as they are, they become clogged in the digestive tract and become difficult to excrete. Therefore, it was found that the eggshell membrane was made into a nano-powdered eggshell membrane, resulting in a food that can be digested and absorbed.
表 3に卵殻膜のアミノ酸含有量 (％)を示す。  Table 3 shows the amino acid content (%) of eggshell membranes.
[表 3] [Table 3]
Figure imgf000006_0001
卵殻膜は、表 3に示すとおり、 18種類のアミノ酸で構成されている。この組成は、人 の毛髪の糸且成と非常に似ている。
Figure imgf000006_0001
As shown in Table 3, the eggshell membrane is composed of 18 kinds of amino acids. This composition is very similar to that of human hair.
この表 3から判るように、卵殻膜は、 18種類の成分の中でシスチンを 13〜： 18%と、 天然の食材の中では非常に多く含んでいる。卵殻膜のシスチンが、人の各部位の再 生能力に優れていることは、すでに本発明者が特許文献 1において開示したとおりで ある。このような卵殻膜の粉末を食することにより、身体の繊維芽細胞が自分自身の 力で増殖し、それが III型コラーゲンを造り出すことが判明した。また、 III型コラーゲン 生成と同時に、その繊維芽細胞が毛母細胞へ増殖されることも、多くの事例から判明 した。 As can be seen from Table 3, eggshell membranes contain 13 to 18% cystine among 18 types of ingredients. It contains a great deal of natural ingredients. The fact that cystine in the eggshell membrane is excellent in the ability to reproduce each part of the human body is as already disclosed in Patent Document 1 by the present inventor. It was found that by eating such eggshell membrane powder, the body's fibroblasts proliferated by their own power, which produced type III collagen. It was also found from many cases that fibroblasts proliferate into hair matrix cells at the same time as type III collagen production.
[0015] 本発明者は、特許文献 2において、加水分解卵殻膜が含有された錠剤を毎日一定 量飲み続けると、発毛 ·育毛促進効果と脱毛防止効果が得られることを明らかにした 。また、その効果をより優れたものとするため、さらに、生体内に生成した活性酸素の 低減又は消去能をより高くするために、卵殻膜とともに、 β—カロチン、ビタミン類及 びローヤルゼリーの内の少なくとも 1種を含有することが好ましぐ β一力ロチン、ビタ ミン類及びローヤルゼリーの 3者を含有することがより好ましいことを開示した。  [0015] In patent document 2, the present inventor has revealed that if a tablet containing a hydrolyzed eggshell membrane is continuously taken in a certain amount every day, a hair growth / hair growth promoting effect and a hair loss preventing effect are obtained. In addition, in order to further improve the effect, and to further increase the ability to reduce or eliminate active oxygen generated in the living body, together with eggshell membranes, among β-carotene, vitamins and royal jelly It is preferable to contain at least one kind. It has been disclosed that it is more preferred to contain β-strength rotin, vitamins and royal jelly.
特許文献 1 :特開 2002— 29031号公報  Patent Document 1: JP 2002-29031 A
特許文献 2：特開 2003— 146895号公報  Patent Document 2: Japanese Patent Laid-Open No. 2003-146895
発明の開示  Disclosure of the invention
発明が解決しょうとする課題  Problems to be solved by the invention
[0016] しかしながら、このような卵殻膜の発毛 ·育毛促進作用と脱毛防止作用の促進剤又 は補助剤として iS—力ロチン、ビタミン類及びローヤルゼリーの 3者を含有させても、 所期の効果を発揮させるためには、錠剤 1個の総重量が卵殻膜約 35〜40mgを含 めて、約 350〜400mg程度にもなるように、 β一力ロチン、ビタミン類及びローヤル ゼリーを含有させる必要がある。すなわち、卵殻膜の成分の利用効率がまだ十分に 高いとは言えず、補助成分のために製造コストが高いものとなる問題があった。また、 所期の効果が発現するまでに、 5〜6年程度の年月がかかった。  [0016] However, even if the iS-strength rotin, vitamins and royal jelly are included as promoters or adjuvants for the effect of promoting hair growth / hair growth and preventing hair loss of such eggshell membranes, In order to exert the effect, β-strength rotin, vitamins and royal jelly are included so that the total weight of one tablet is about 35 to 40 mg including eggshell membrane and about 350 to 400 mg. There is a need. That is, it cannot be said that the utilization efficiency of the eggshell membrane component is sufficiently high, and there is a problem that the production cost is high due to the auxiliary component. In addition, it took about 5 to 6 years to achieve the desired effect.
[0017] 本発明は、上記の点に鑑みてなされたものであり、その課題は、卵殻膜の優れた発 毛-育毛促進作用と脱毛防止作用を促進し又は補助するより好適なものを用レ、ること により、低コストで、し力も、比較的短期間で確率の高い発毛 ·育毛効果が得られるサ プリメントを提供することにある。  [0017] The present invention has been made in view of the above points, and the object thereof is to use a more suitable one that promotes or assists the excellent hair growth-hair growth promoting action and hair loss preventing action of eggshell membranes. Therefore, it is intended to provide a supplement that can produce a hair growth / hair growth effect with a low cost and a high probability in a relatively short period of time.
課題を解決するための手段 [0018] 上記課題を解決するため、本発明に係る発毛 ·育毛用サプリメントは、卵殻膜粉末 と、加水分解ケラチンと、イチヨウ葉エキスとを含有することを特徴としている（請求項 1 Means for solving the problem [0018] In order to solve the above-described problems, the hair growth / hair growth supplement according to the present invention is characterized by containing eggshell membrane powder, hydrolyzed keratin, and yew leaf extract (claim 1).
[0019] 卵殻膜粉末は、これを食べると、身体の繊維芽細胞がそれ自身の力で増殖し、 III 型コラーゲンが造り出されると同時に、その繊維芽細胞が毛母細胞を増殖する。さら に、卵殻膜に多量に含まれるシスチンは身体の各部位の再生能力が高ぐその能力 の高さは、他のどの食材も比較にならない程高い。ケラチンは、 20種類のアミノ酸が 結合してできた、繊維に富む丈夫なタンパク質であり、毛髪などを形成している細胞 中の物質の大部分を構成するものである。イチヨウ葉エキスは、体内での優れた血行 促進作用により卵殻膜粉末とケラチンの有効成分を効果的に細胞に送り届ける。こ のため、頭皮、頭髪の機能が亢進され、発毛'育毛効果が一層向上され、顕著に発 現する。卵殻膜とケラチンが合わさることにより、まつげ、眉毛なども育毛され、太ぐ 長く伸びることが確認されてレ、る。 [0019] When the eggshell membrane powder is eaten, the body's fibroblasts proliferate with its own power, and type III collagen is produced, and at the same time, the fibroblasts proliferate the hair matrix cells. In addition, cystine, which is abundant in eggshell membranes, has a high ability to regenerate each part of the body, and its ability is high compared to any other food. Keratin is a strong fiber-rich protein made by binding 20 kinds of amino acids, and constitutes most of the substances in cells that form hair. The yew leaf extract effectively delivers eggshell membrane powder and active ingredients of keratin to cells by promoting blood circulation in the body. For this reason, the functions of the scalp and hair are enhanced, and the hair growth effect is further improved, which is remarkably expressed. By combining eggshell membranes and keratin, the eyelashes and eyebrows are also grown, and it has been confirmed that they grow thick and long.
[0020] また、本発明に係る発毛 ·育毛用サプリメントは、消化吸収を助けるビタミン類を含 むことを特徴としてレ、る（請求項 2)。  [0020] Further, the hair growth / hair growth supplement according to the present invention contains vitamins that help digestion and absorption (claim 2).
ビタミン類、例えばビタミン B2は、卵殻膜とケラチンの有効成分の体内での消化吸 収を助けるため、有効成分が毛髪の生成に効率的に利用される。  Vitamins such as vitamin B2 help the digestive absorption of eggshell membranes and keratin active ingredients in the body, so that the active ingredients are efficiently used for hair production.
[0021] さらに、本発明に係る発毛 ·育毛用サプリメントは、カプセル剤形に成形され、 1カブ セル内に 250mg前後が含まれていることを特徴としている（請求項 3)。  [0021] Furthermore, the hair growth / hair growth supplement according to the present invention is formed into a capsule dosage form, and about 250 mg is contained in one capsule (claim 3).
[0022] 本発明に係る発毛 ·育毛用サプリメントは、卵殻膜粉末を 10〜30質量％、加水分 解ケラチンを 10〜30質量0 /0、イチヨウ葉エキスを 1〜15質量0 /0、ビタミン B2を 0. 5〜 10質量％、抗酸化物を 1〜： 10質量％含有することが好ましい (請求項 4)。 [0022] hair growth and hair growth supplements according to the present invention, the eggshell membrane powder 10 to 30 mass%, the pressurized water solutions keratin 10 to 30 mass 0/0, 15 mass Itiyou leaf extract 0/0, It is preferable to contain 0.5 to 10% by mass of vitamin B2 and 1 to 10% by mass of antioxidant (claim 4).
[0023] 本発明に係る最も好ましい発毛 ·育毛用サプリメントは、卵殻膜粉末を 22質量％、 加水分解ケラチンを 20質量％、イチヨウ葉エキスを 6質量％、ビタミン B2を 0. 5質量 %、抗酸化物を 8質量％含有することを特徴としてレ、る (請求項 5)。  [0023] The most preferred hair growth / hair growth supplement according to the present invention is 22% by mass of eggshell membrane powder, 20% by mass of hydrolyzed keratin, 6% by mass of yew leaf extract, 0.5% by mass of vitamin B2, It is characterized by containing 8% by mass of an antioxidant (Claim 5).
発明の効果  The invention's effect
[0024] 請求項 1の発明によれば、卵殻膜粉末が身体の繊維芽細胞の増殖、 III型コラーゲ ンの創成、繊維芽細胞からの毛母細胞の増殖をもたらし、卵殻膜は高い細胞再生能 力を有するシスチンを多量に含み、ケラチンは髪構成成分であって、これら卵殻膜と ケラチンの有効原料の成分力 Sイチヨウ葉エキスの体内での優れた血行促進作用によ り効果的に細胞に送り届けられるため、頭皮、頭髪の機能が亢進される結果、発毛- 育毛効果又は脱毛防止効果及びその促進効果が格段に向上され、比較的短期間 の内に顕著にその効果が発現する。 [0024] According to the invention of claim 1, the eggshell membrane powder causes the proliferation of the body fibroblasts, the creation of type III collagen, the growth of hair matrix cells from the fibroblasts, and the eggshell membrane has a high cell regeneration. Noh It contains a large amount of cystine, and keratin is a component of hair, and is an effective ingredient of these eggshell membranes and keratin. As a result of the delivery, the functions of the scalp and hair are enhanced. As a result, the hair growth-hair growth effect or the effect of preventing hair loss and the promotion effect thereof are remarkably improved, and the effect is remarkably exhibited within a relatively short period of time.
[0025] 請求項 2の発明によれば、卵殻膜とケラチンの有効成分の体内での消化吸収がビ タミン類により補助促進されるので、発毛 ·育毛効果又は脱毛防止効果及びその促 進効果が一層向上する。 [0025] According to the invention of claim 2, digestion and absorption of eggshell membranes and active ingredients of keratin in the body are aided and promoted by vitamins, so that hair growth / hair growth prevention effect or hair loss prevention effect and its promotion effect Is further improved.
[0026] 請求項 3の発明によれば、所定量が収容されたカプセルタイプで提供されるので、 携帯に便利で有り、有効量を食すること及び長期間継続することが容易にできる。 [0026] According to the invention of claim 3, since it is provided in a capsule type containing a predetermined amount, it is convenient to carry and can easily eat an effective amount and continue for a long period of time.
[0027] 請求項 4及び請求項 5の発明によれば、有効な発毛及び又は育毛効果を低コスト で確実に提供することができる。 [0027] According to the invention of claim 4 and claim 5, it is possible to reliably provide an effective hair growth and / or hair growth effect at low cost.
発明を実施するための最良の形態  BEST MODE FOR CARRYING OUT THE INVENTION
[0028] 本発明によるサプリメントは、毛髪の発育促進のため、上記二つの主原料、すなわ ち、卵殻膜粉末及び加水分解ケラチンに、イチヨウ葉エキスを加えてある。イチヨウ葉 エキスは、摂取することにより、血行促進効果が得られ、また、頭皮及び頭髪の機能 を亢進させる作用を有する。従って、イチヨウ葉エキスを加えたことにより、本発明品 の発毛 ·育毛効果は一層向上した。 [0028] The supplement according to the present invention is obtained by adding a leaf extract to the above two main raw materials, ie, eggshell membrane powder and hydrolyzed keratin, in order to promote hair growth. When taken, it extracts blood circulation and has the effect of enhancing the functions of the scalp and hair. Therefore, the hair growth / hair growth effect of the product of the present invention was further improved by adding the yew leaf extract.
[0029] 本発明品には、さらにビタミン類、例えば、ビタミン B2を添加してある。卵殻膜粉末 を用いることにより、上述したように本来、消化吸収しにくい卵殻膜が消化吸収が可 能となったが、ビタミン類は、卵殻膜及びケラチンの体内での消化吸収を助ける作用 をする。従って、本発明品では、卵殻膜及びケラチンの成分が非常に効率的に毛髪 の生成に用いられる。 [0029] The product of the present invention further contains vitamins such as vitamin B2. By using eggshell membrane powder, eggshell membranes that are inherently difficult to digest and absorb can be digested and absorbed as described above, but vitamins help digestive absorption of eggshell membranes and keratin in the body. . Therefore, in the product of the present invention, eggshell membranes and keratin components are used very efficiently for the production of hair.
[0030] 卵殻膜粉末の配合率の有効範囲は 10〜50質量％であり、最適値は 22質量％前 後である。 10%未満の場合は多数のモニターが使用した結果、効果が薄いことが判 明した。 50%を超える場合は、元来卵殻膜が消化しにくいため、消化するのに胃に 負荷がかかり、消化不良になりやすい。 50%にする場合は、他の成分の配合率を総 計 100%になるように調整する。 加水分解ケラチンの配合率の有効範囲は 10〜30質量％であり、最適値は 20質量 %前後である。 10%未満の場合は効果が薄 30%を超える場合は消化の問題と、 他の配合成分とのバランスが崩れるので好ましくない。 [0030] The effective range of the mixing ratio of the eggshell membrane powder is 10 to 50% by mass, and the optimum value is before and after 22% by mass. When it was less than 10%, many monitors used it, and it was found that the effect was weak. If it exceeds 50%, the eggshell membranes are inherently difficult to digest, so digestion is burdened by the stomach and tends to cause indigestion. If it is 50%, adjust the blending ratio of other ingredients to 100% in total. The effective range of the hydrolysis keratin content is 10-30% by mass, and the optimum value is around 20% by mass. If it is less than 10%, the effect is less than 30%. This is not preferable because the balance between digestion problems and other ingredients is lost.
イチヨウ葉エキスの配合率の有効範囲は 1〜15質量％であり、最適値は 6質量％前 後である。 1%未満であると効果が薄 15%を超えると他の配合成分とのバランスが 崩れるため好ましくない。  The effective range of the ratio of the yew leaf extract is 1 to 15% by mass, and the optimum value is around 6% by mass. If it is less than 1%, the effect is less than 15%, and the balance with other ingredients is lost.
ビタミンの配合率の有効範囲は 0. 5〜： 10質量％であり、最適値は 0. 5質量％であ る。 0. 5%未満の場合は効果が薄ぐ 10%を超えると体内残留量が多くなり、健康を 害するので好ましくない。ビタミンは適量を超える過剰分は自ずと排出されると考えら れているが、過剰ビタミンは体内に残留するものであると考えられ、その体内残留量 が過多になると健康を害するおそれもある。この点を考慮して配合率を少なめに抑え てある。  The effective range of vitamin content is 0.5 to 10% by mass, and the optimum value is 0.5% by mass. Less than 5% is less effective. If it exceeds 10%, the remaining amount in the body increases, which is unfavorable because it may harm your health. Vitamins are considered to be excreted in excess of the appropriate amount, but excess vitamins are thought to remain in the body, and excessive amounts in the body may harm health. Considering this point, the blending ratio is kept low.
抗酸化物の配合率の有効範囲は 1〜： 10質量％であり、最適値は 8質量％である。 1%未満の場合は効果がなぐ 10%を超える場合は他の配合材料とのバランスが崩 れるため好ましくない。  The effective range of the antioxidant content is 1 to 10% by mass, and the optimum value is 8% by mass. If it is less than 1%, the effect is insufficient. If it exceeds 10%, the balance with other compounding materials is lost, which is not preferable.
[0031] 本発明は、栄養補助食品の使命を厳守する目的で、発毛'育毛に良い原料のみを 重点的に多く配合するのではなぐ有効成分がそれぞれ最も効果を発揮するように 各成分全体をバランス良く配合している。発明者はこのことが最も大切なことであると の信念をもって実施した。  [0031] For the purpose of strictly adhering to the mission of dietary supplements, the present invention is intended to ensure that each active ingredient exhibits its most effective effect, rather than adding only ingredients that are good for hair growth and hair growth. Is well balanced. The inventor carried out with the belief that this was the most important thing.
実施例 1  Example 1
[0032] 上記本発明に基づく実施例として、内容量 250mgの 2号白カプセル状の錠剤形の 発毛'育毛用サプリメントを試作した。その原材料名及び配合率並びに 1粒当たり含 有量は、表 4に示すとおりである。  [0032] As an example based on the present invention, a No. 2 white capsule-like tablet-shaped hair growth supplement for hair growth having an internal volume of 250 mg was produced. Table 4 shows the raw material names, blending ratio, and content per grain.
[表 4] 原材料名 配合率 （％) 1粒当たり含有量 (m g) 卵殻膜粉末 2 2. 0 0 5 5. 0 0 [Table 4] Raw material name Mixing ratio (%) Content per grain (mg) Eggshell membrane powder 2 2. 0 0 5 5. 0 0
ケラチン粉末 2 0. 0 0 5 0. 0 0  Keratin powder 2 0. 0 0 5 0. 0 0
イチヨウ葉エキス 6. 0 0 1 5. 0 0 昆布粉末 5. 0 0 1 2. 5 0 Yewyo Leaf Extract 6. 0 0 1 5. 0 0 Kelp Powder 5. 0 0 1 2. 5 0
C o Q l 0 3. 0 0 7. 5 0 ビタミ ン C 5. 0 0 1 2. 5 0 ビタミ ン B 2 0. 5 0 1. 2 5 ビタミン E 2 0 %品 3. 0 0 7. 5 0 賦形剤 3 5. 5 0 8 8. 7 5 合計 1 0 0. 0 0 2 5 0. 0 0 C o Q l 0 3. 0 0 7. 5 0 Vitamin C 5. 0 0 1 2. 5 0 Vitamin B 2 0. 5 0 1. 2 5 Vitamin E 2 0% product 3. 0 0 7. 5 0 Excipient 3 5. 5 0 8 8. 7 5 Total 1 0 0. 0 0 2 5 0. 0 0
[0033] 上記ビタミン C及びビタミン Eは、抗酸化剤として用いられている。ビタミン C及びビタ ミン Eには、強い抗酸化作用があり、また、ビタミン Eは老化防止ビタミンとも言われ、 血行促進作用及び血液循環正常化作用がある。ビタミン B2には成長を促すとともに 、皮膚を正常に保つ働きがある。 [0033] Vitamin C and vitamin E are used as antioxidants. Vitamin C and vitamin E have a strong antioxidant action, and vitamin E is also called an anti-aging vitamin, and has a blood circulation promoting action and a blood circulation normalizing action. Vitamin B2 promotes growth and keeps the skin healthy.
[0034] [製造方法]  [0034] [Production method]
本発明に係る発毛 ·育毛用サプリメントの製造方法の一例を説明する。表 4に示さ れた各原料を含有水分が 10%前後になるように脱水乾燥する。その後、全ての粒が 均一な大きさになるように十分注意しながら撹拌造粒する。酸化しないような形状に 賦形し、カプセル錠、セラック錠、顆粒、又は糖衣錠などにする。  An example of a method for producing a hair growth / hair growth supplement according to the present invention will be described. Each raw material shown in Table 4 is dehydrated and dried so that the water content is around 10%. Then, stir and granulate with sufficient care so that all the grains are uniform. Shape into a shape that will not oxidize and make capsules, shellac tablets, granules, or sugar-coated tablets.
[0035] [試用結果] [0035] [Trial result]
発明者は、 35歳頃から頭頂部に半径 5cm程度のほぼ円形の大きさで「禿」が始まり 、 50歳台では完全に光り、それを隠蔽するのに苦労し、 50歳台半ばでは隠せないよ うになつてしまった。市販の有名な発毛 ·育毛剤を 3〜4種類、いろいろと使用したが 、 目立った効果は現れなかった。 67歳から本発明品（内容量 250mgの 2号白カプセ ル状の錠剤形の発毛 ·育毛用サプリメント）を食べ始めた結果、今までに見られない 効果が出た。つまり、光っている部分には、短く目に見えないような「産毛」が少量あ つたが、 1日 2〜3粒、毎日食べ続けたところ、使用開始日から 2ヶ月経過した頃から 産毛が黒くて太くなり、発明者自身、 自分の年齢からしても信じられない程の効果が 現れた。本発明品の食用開始からほぼ 1年後には、頭頂の光った部分が見えにくく なった。頭髪に限らず、他の部位の毛にも同様の発毛 ·育毛効果が現れた。 The inventor started the heel with a radius of about 5cm at the top of the head from around 35 years old, completely shining in the 50s, struggling to conceal it, and concealing in the mid 50s I got lost. Three to four types of famous hair growth and hair growth agents on the market were used in various ways, but no noticeable effect appeared. As a result of starting eating the product of the present invention (No. 2 white capsule-shaped hair growth / hair growth supplement with an internal volume of 250 mg) from the age of 67, an effect never seen before was achieved. In other words, there are a small amount of short hair that cannot be seen in the shining area. However, when I continued to eat 2 to 3 capsules a day, the hair growth became black and thick after 2 months from the start of use, and the inventor himself had an incredible effect even from his own age. Appeared. Almost one year after the start of edible use of the product of the present invention, it became difficult to see the illuminated part of the crown. The same effect of hair growth and hair growth appeared not only in the hair but also in other parts of the hair.

Claims

請求の範囲 The scope of the claims
[1] 卵殻膜粉末、加水分解ケラチン及びイチヨウ葉エキスを含有することを特徴とする 発毛及び又は育毛用栄養補助食品。  [1] A dietary supplement for hair growth and / or hair growth, comprising eggshell membrane powder, hydrolyzed keratin and yew leaf extract.
[2] 消化吸収を助けるビタミン類を含むことを特徴とする請求項 1に記載の発毛及び又 は育毛用栄養補助食品。 [2] The nutritional supplement for hair growth and / or hair growth according to claim 1, comprising vitamins that aid digestion and absorption.
[3] カプセル剤形に成形され、 1カプセル内に 250mg前後が含まれていることを特徴と する請求項 1又は 2に記載の発毛及び又は育毛用栄養補助食品。 [3] The nutritional supplement for hair growth and / or hair growth according to claim 1 or 2, characterized in that it is formed into a capsule dosage form, and about 250 mg is contained in one capsule.
[4] 卵殻膜粉末を 10〜30質量％、加水分解ケラチンを 10〜30質量％、イチヨウ葉ェ キスを 1〜： 15質量％、ビタミン B2を 0. 5〜： 10質量％、抗酸化物を:!〜 10質量％含有 することを特徴とする請求項 1に記載の発毛及び又は育毛用栄養補助食品。 [4] 10-30% by weight of eggshell membrane powder, 10-30% by weight of hydrolyzed keratin, 1-: 15% by weight of citrus leaf, 0.5%: 10% by weight of vitamin B2 The dietary supplement for hair growth and / or hair growth according to claim 1, comprising:!
[5] 卵殻膜粉末を 22質量％、加水分解ケラチンを 20質量％、イチヨウ葉エキスを 6質量[5] 22% by mass of eggshell membrane powder, 20% by mass of hydrolyzed keratin, and 6% of yew leaf extract
%、ビタミン B2を 0. 5質量％、抗酸化物を 8質量％含有することを特徴とする請求項%, Vitamin B2 0.5% by mass, and antioxidant 8% by mass
4に記載の発毛及び又は育毛用栄養補助食品。 4. Nutritional supplement for hair growth and / or hair growth as described in 4.
PCT/JP2006/309539 2006-01-23 2006-05-12 Nutritional supplement for promotion of hair growth and/or hair restoration WO2007083402A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006013507 2006-01-23
JP2006-013507 2006-01-23
JP2006-030565 2006-02-08
JP2006030565 2006-02-08

Publications (1)

Publication Number Publication Date
WO2007083402A1 true WO2007083402A1 (en) 2007-07-26

Family

ID=38287363

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/309539 WO2007083402A1 (en) 2006-01-23 2006-05-12 Nutritional supplement for promotion of hair growth and/or hair restoration

Country Status (2)

Country Link
TW (1) TW200738179A (en)
WO (1) WO2007083402A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019043128A1 (en) * 2017-09-01 2019-03-07 Bretagne Chimie Fine Keratin hydrolysate for oral cosmetic use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001238637A (en) * 2000-03-03 2001-09-04 Fancl Corp Food composition
JP2001321121A (en) * 2000-05-11 2001-11-20 Ichimaru Pharcos Co Ltd Hair growing and restoring food and drink
JP2003146895A (en) * 2001-08-31 2003-05-21 Almado Co Ltd Tablet including ephippium
JP2004229534A (en) * 2003-01-29 2004-08-19 Yukio Hasebe Hydrolyzed eggshell membrane-containing drink

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001238637A (en) * 2000-03-03 2001-09-04 Fancl Corp Food composition
JP2001321121A (en) * 2000-05-11 2001-11-20 Ichimaru Pharcos Co Ltd Hair growing and restoring food and drink
JP2003146895A (en) * 2001-08-31 2003-05-21 Almado Co Ltd Tablet including ephippium
JP2004229534A (en) * 2003-01-29 2004-08-19 Yukio Hasebe Hydrolyzed eggshell membrane-containing drink

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KOBAYASHI N.: "EFFECTS OF LEAVES OF GINKGO BILOBA ON HAIR REGROWTH IN C3H STRAIN MICE", PHARMACEUTICAL SOCIETY OF JAPAN. JOURNAL - YAHUGAKU ZASSHI, PHARMACEUTICAL SOECIETY OF JAOAN, TOKYO, JP, vol. 113, no. 10, 10 January 1993 (1993-01-10), pages 718 - 724, XP000607032 *
KUBO M.: "Tokushu/Mobo Saibo no Kasseika to Ikumozai no Kaihatsu Ichoha Extract no Ikumo Koka to Massho Kekko Kaizen Koka", FRAGRANCE JOURNAL, vol. 21, no. 9, 1993, pages 27 - 36, XP003010896 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019043128A1 (en) * 2017-09-01 2019-03-07 Bretagne Chimie Fine Keratin hydrolysate for oral cosmetic use
FR3070600A1 (en) * 2017-09-01 2019-03-08 Bretagne Chimie Fine KERATIN HYDROLYSAT, ORAL COSMETIC USE OF THIS HYDROLYZATE FOR IMPROVING THE QUALITY OF PHANESES AND SUPPLEMENTS CONTAINING THE SAME
US11980680B2 (en) * 2017-09-01 2024-05-14 Bretagne Chimie Fine Keratin hydrolysate for oral cosmetic use

Also Published As

Publication number Publication date
TW200738179A (en) 2007-10-16

Similar Documents

Publication Publication Date Title
KR101702851B1 (en) The hair follicle and hair growth promoter composition improved with edible crickets
CN108651998A (en) It is a kind of have relieve fatigue PURE WHEY of function and preparation method thereof
JP2012171901A (en) Food for oral-intake for hair growth of men
JP2010535493A (en) Production process for animal feeding products and animal products
JP2004238365A (en) Skin beautifying agent, and beauty and health food
CN105769725A (en) Rosemary moisturizing water and making method thereof
JP2007070316A (en) Peroral composition and dietary supplement
KR20100016876A (en) A mixed grain for diet and glycosuria
CN1833722A (en) Health products for face care and body care
KR19990084077A (en) Low Sugar Functional Foods to Improve Obesity
CN108541912A (en) A kind of anti-oxidant blood-fat reducing composition and its preparation method and application
JP2006191845A (en) Food composition and method for producing the same
JP2004229534A (en) Hydrolyzed eggshell membrane-containing drink
KR20160096294A (en) Crickets for improved liver function, liver cancer, hangover solutions, fatigue recovery and food compositions comprising the same
JPH10165138A (en) Beauty making and health food
WO2007083402A1 (en) Nutritional supplement for promotion of hair growth and/or hair restoration
KR20110121246A (en) Natural functional food for anti-obesity wellbeing diet and its producing method
CN102960603B (en) Nutrient protein powder with high digestive absorption function
JP2007236383A (en) Nutritional supplement for promotion of hair growth and/or hair restoration
CN109845870A (en) A kind of haematococcus pluvialis vitamin C pressed candy and preparation method thereof
WO2014134834A1 (en) Composition and food comprising same and preparation method of food
KR102322276B1 (en) Beverage composition for preventing obesity and relieving edema
KR102266858B1 (en) Manufacturing method of feed for layer chicken
CN112586740A (en) Protein product and preparation method thereof
JP2007037416A (en) Function-enhanced supplementary food

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06746336

Country of ref document: EP

Kind code of ref document: A1