JP2006188463A - Melanin-formation inhibitor and cosmetic composition comprising the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a novel and safe melanin-formation inhibitor and a cosmetic composition. <P>SOLUTION: The melanin-formation inhibitor comprises at least one plant extract selected from among Salacia reticulata, Salacia chinensis and Salacia oblonga. The cosmetic composition comprising the same is also provided. The melanin-formation inhibitor and the cosmetic composition significantly suppress the formation of a melanin dye, exhibit beautifying and whitening effects, improves spots and freckles on the skin, and whiten the skin color. The melanin-formation inhibitor and the cosmetic composition improve tightness and gloss of the skin and are effective for preventing ageing of skins and scalps. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an application to a melanin production inhibitor or cosmetic composition containing one or more plant extracts selected from Salacia reticulata, Salacia chinensis and Salacia oblonga.

  Factors that determine human skin color include the amount of melanin in the epidermis, blood flow in capillaries, food-derived pigments (carotene), and the thickness of the stratum corneum. One is melanin pigment. The so-called liver spots (spots), sparrow eggs (sobacus), and skin pigmentation after sunburn are markedly enhanced production of melanin pigments due to the activation of pigment cells in the skin. It has become one of the major skin problems for women.

  This melanin is produced in melanosomes, which are organelles in pigment cells (melanocytes) present in the basal layer of the epidermis, the hair root, and the outer root sheath. In the process of melanin pigment formation, tyrosinase acts on tyrosine in pigment cells (melanocytes), tyrosin is oxidized, converted to dopa and dopaquinone, and further auto-oxidized, and polymerized via dopachrome and 5,6-dihydroxyindole. Finally, it becomes a melanin pigment. The produced melanin is secreted from the dendrites of pigment cells (melanocytes) to the basal cells, and the basal cells divide and become spiny cells, and then rises. It is supposed to go.

Therefore, in order to prevent or ameliorate skin liver spots (spots), sparrow egg spots (sobacas), and darkness, the production process of melanin is inhibited. Alternatively, it may be possible to lighten the already produced melanin. Therefore, various whitening components have been proposed based on these ideas. For example, kojic acid or its derivative, ascorbic acid or its derivative, tocopherol or its derivative, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract or plant extract (Arnica, Altea , Aloe, oxon, enamel, chamomile, licorice, gardenia, genus shochu, sikon, shouma, birch, nematode, genus shochu, psycho, wildflower, toki, dragonflower, elderberry, safflower, garlic, pearl beet, litchi, logwood), etc. Various whitening agents have been developed so far (see, for example, Non-Patent Document 1).
Noriyuki Omori, FRAGRANCE JOURNAL Special Issue, No. 14, 1995, 118-126

  However, for the above-mentioned whitening component, the stability and solubility in the prescription system are poor, the odor and coloring due to starch and decomposition occur, the effect at the biological level is not sufficient, and the skin is irritated, etc. There was a problem in terms of safety and it was not satisfactory.

  On the other hand, Salacia reticulate, Salacia chinensis and Salacia oblonga used in the present invention are climbing and perennial woody plants belonging to the genus Salacia or Dechinmuraceae. is there. These plants native to Sri Lanka, India, Thailand, etc. have been used as natural drugs in traditional medicine in Sri Lanka, Indian traditional medicine “Ayurveda” and in Southeast Asia such as Thailand.

  In particular, Kothalahimbutu, also known as Salacia reticulate, native to Sri Lanka, is a Sinhala Sinhala word meaning “grace from God”. It has been used for more than a year. Salacia reticulate has been developed by Sri Lanka's topographical factors, a monsoon climate with distinct dry and rainy seasons, and unique soil conditions, and has evolved into a species with many active ingredients. It has been broken.

  In these plants belonging to the genus Salacia, kotaranol and salacinol, which are sulfur-containing compounds, are known as unique components, and α-glucosidase activity inhibitory action, blood sugar level increase inhibitory action and the like are known, respectively.

From these actions, application examples and patents (Patent Documents 1 to 4) as antidiabetic preventive agents are seen in consideration of application to foods and pharmaceuticals, but knowledge about the whitening action has not been known so far. Moreover, the application to skin external preparations, such as cosmetics, is not seen.
Japanese Patent Laid-Open No. 09-301882 Japanese Patent Laid-Open No. 11-029472 Japanese Patent Application Laid-Open No. 11-049792 JP 2003-063974 A

  In view of these circumstances, the present inventors have developed a useful natural ingredient that has a strong effect on the living body level and has a melanin production inhibitory action that has no problems in both stability and safety. An object of the present invention is to provide a whitening component and its application that effectively suppress and improve skin pigmentation such as skin darkening caused by dullness or ultraviolet exposure.

  As a result, it was confirmed that one or more plant extracts selected from Salacia reticulata, Salacia chinensis and Salacia oblonga significantly suppressed the production of melanin pigments and had a whitening effect. These complete the present invention with a highly safe melanin production inhibitor and a cosmetic composition containing the same, which can improve skin spots and freckles, and can further improve skin tension and gloss. It came to.

  Melanin production inhibitor or cosmetic composition containing various plant extracts of Salacia reticulata, Salacia chinensis and Salacia oblonga of the present invention significantly suppresses the production of melanin pigment, has a whitening effect, and has a skin whitening effect. To improve spots and freckles, and to improve the skin color to white. Furthermore, skin tension and gloss can be improved. Therefore, it is effective for preventing aging of the skin and scalp. It can be used for other general foods and drinks.

  One or more plant extracts selected from Salacia reticulata, Salacia chinensis, and Salacia oblonga used in the present invention are obtained by extracting various parts of a plant body as they are or after pulverization. Alternatively, it is extracted as it is or after pulverization with a solvent.

  The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the intended purpose and type of the product to be provided, or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol are used. Among various organic solvents such as lower alcohols such as isopropyl alcohol, butanol and isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or water-containing polyhydric alcohols, acetone and ethyl acetate. It is desirable to use one or a mixture of two or more selected from However, when it is not preferable to contain an organic solvent depending on the purpose of use, only water may be used, or ethanol that is easy to remove after extraction may be used alone or in any mixture with water. , Exploited and extracted. Furthermore, it can be used in a state where each solvent extract is combined.

  In addition to hydrolytic extraction of the above-mentioned various plants by enzymatic decomposition, those obtained by hydrolyzing with acid / alkali can also be used.

  There is no particular limitation on the production method, but usually it may be in the range of the boiling point of the solvent from room temperature to normal pressure. , Paste, gel, and powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decoloration may be added as long as the effect is not affected. An activated carbon column or the like may be used, and usual means generally applied depending on the extracted substance may be arbitrarily selected. In addition, an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, or any mixed solution thereof can be added to the extracted liquid after extraction. Although the obtained extract can be used as it is, it can be concentrated and dried to be used as a paste or powder.

  One or more plant extracts selected from Salacia reticulata, Salacia chinensis and Salacia oblonga of the present invention can be contained in a melanin production inhibitor and a cosmetic composition, and the content thereof is not particularly specified. Melanin production inhibitor, cosmetic composition type, quality, slightly different depending on the degree of expected action, usually 0.0001% by mass or more (hereinafter expressed as%) in terms of solid content in the total amount of the preparation, preferably 0.01 to 50.0% is good. In the case of a bath preparation, the prescription may be considered so that it is poured into 200 to 300 L of bath water to obtain a similar concentration.

  The dosage form / form of the melanin production inhibitor or cosmetic composition of the present invention is arbitrary, and it is blended in the form of capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, sheet, etc. Can be used.

  The field of use can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids, gels 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (for example, lotion, milky lotion) Basic cosmetics such as creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, hair removers, shaving treatments, after-shave lotions, pre-show lotions, Makeup cosmetics such as shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail preparation, nail enamel, nail enamel Leavening agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, hairs) Treatment agents, pre-hair treatment agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plaster agents, tape agents, sheet agents, patch agents, aerosol agents, etc.), 5) bath water 6) Others, anti-odor and deodorant, deodorant, antiperspirant, hygiene products, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, dishwashing agent Etc.

  The melanin production inhibitor or cosmetic composition of the present invention is optionally selected and used in combination with the components and additives exemplified below within the range that does not impair the effects of the present invention, if necessary, in addition to the above essential components. Although the content in the preparation is not particularly specified, it is usually preferably 0.0001 to 50%.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil , Shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, palm Oil, beef tallow, pork tallow, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil, etc.).

(2) Wax beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.

(3) Mineral oil liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid Natural fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) Alcohols Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol .

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, Diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) gum, saccharides or water-soluble polymer compound gum arabic, benzoin gum, danmar gum, guaiac gum, Irish moss, Karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or esters thereof, Trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular chitin Or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose, Polycarboxylate such as carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide Alkylene oxide or its crosslinked polymer, carboxyvinyl polymer, polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric Surfactant: Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant ( Ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants ( Natural surfactants, protein hydrolyzate derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbons Surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), Riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: Ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), mena Dione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine , Arginine, ornithine, histidine and the like, and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate or pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, fermentation, purification) , Compression, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., arbitrarily selected and combined), arbitrarily selected from various materials You can use it.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. One or two selected from various alcohols such as lower alcohols such as butanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, acetone and ethyl acetate It is desirable to use a mixture of seeds or more. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.

  In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relieving stress, relieving stress due to fragrance, cell activation (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing and improving rough skin, hair growth, hair growth, preventing hair loss, imparting luster, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and bathing effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.

Specific plants (herbal medicines) as raw materials include, for example, almonds (toen), ai (indigo leaves), aokazura (Keifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Samurai (wooden candy) , Aotenma, acacia, red ginseng, red spruce `` fruit '', red clover, red grapes, red ginseng (logwood), red wrinkles (red buds), red crested or red crested or reddish (root), red crested or reddish (ground yellow), Agi (Aki), Aki larch, Akinire (crusted skin), Aguay Guassou, Aguahe (Omiten coconut palm), Akebi (Kitsu), Asa (Asakojin), Maruba morning glory or morning glory (Chicken), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asenyaku), Athira (Shokuyokanna), Anise, Abiyu, A Biurana, oilseed rape, Abemaki `` fruit '', avocado, ama, achacha (Amacha), Achacharu, Amadokoro (Jade bamboo), Amana (a light-hearted), amaranth (Hyuyu, Hagatetou, Himogeito, Senninkoku, Sugimorigateto, Hosoaogeito, Hasoagoito Aozulan, Amaranthus hypochondriacus), Amigasayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Arcana (Alcanna), Algarrobo (Cabe), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe (蘆薈), Aloe vera, angelica, apricot or honanzu (Anzujin), Ansokkou (benzoic incense), yellow support, igakozolina (geo-biliary head), licorice or gecko licorice (indian oyster), rush (light heart grass), itadori (tiger cane root), yew (one Place), Strawberry, fig (no flower `` fruit, leaf ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one medicinal herb), ginkgo (Ginkgo `` seed, leaves ''), Japanese yellow peas (distant), carob, Japanese beetle ( Taillexi), Inubiyu (Honagainubiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibuki-so-sou, Nettle, Ylang-ylang, Iwa-tobacco (Iwabuchi), Iwahiba or Iwamatsu (rolling mushroom), kidney beans, oolong tea, fennel (mustard) , Wheat (Chibusanoki), Ukiyara (Sanryo), Uguisukagura `` Fruit '', Himewikyo, Turmeric (Urban), Duckweed, Usubasaishin or Keirinsaishin or Oshusaishin (spicy), Usvenia Oy, Usbeni Hollyhock, phalaenopsis, weevil (summer hay), udo or shishiudo (gung, alone, tangy), unyadegato (unkari) A, Cat's Claw), Uba tea, Ume (Japanese apricot `` seed, pulp ''), Japanese white beetle, Uwaurushi (Kusako-kemomo), Unshuumika (Chen), Unboku, Estragon, Ezoukogi (Tomogoka), Ezo-suzuran, Echinashi (Hosobamurasaki Barengiku) , Enishida, Enokitake (榎 茸), Ebisugusa or Cassia Tora (Keiko), El Campre, Elderberry “fruit”, Elemi, Elingi or Pre-Lotus Elinji, Enju (Safflower, Camellia rice), Pea, Ogi or Kibanaogi (Yellow Twilight), Naruko Yuri or Kagura-mabanaru Koyuri (Yellow), Ohisasa Yuki or Sasano Yuki, Ouren (Yo Ren), Ogata Houken, Okarasuri (Karokon), Oguruma (Civil Works Incense), Otsu Samurai (Prevention), Psyllium , Car forage), toucan thistle (Zhengzhou leakage, bald eagle), toucan Mi (coconut palm), Toucan cactus, Ovana okera or okera (white moth), Osara squirrel (Banaba), Ooyabaya shabushi "fruit", Oohashigusa (cereal sperm), Omia catechu, Oomihasa or Hawthorn (Mountain vegetation), Omiyashi, Omiji Barley), Oka, Okazeri (snake bed), Okra `` fruit '', Oguruma (overturn), Oguri higotai (Zhengzhou leakage, indigo head), Panax ginseng or Tochibaninjin (Ginseng), Hypericum pertussis or Pterotus pertussis or Hypericum perforatum (Brothers cut grass), Odrichossou (continuous), Onamomi (Circle ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyara (Tempa), Onoelan, Ononis, Halibut (Kirihagi), Ominaeshi (defeated sauce), Oyuko, Dutch mustard (watercress), Dutch jellies, Dutch ville, Dutch honey bees, Oh -"Fruits, Seeds, Leaves", Oregano, Orange "Fruits, Peels", Silkworms (ripe yellow), Cacao "Fruits, Peels, Seeds", Oysters (Powder "Leaves"), Kagi Kazura (Tsukado) , Kakidooshi or Kantori (Lotus herb), Kakiran, Gaku hydrangea, Cassia, Casino oyster (fruit `` fruit ''), Gadju (莪 朮), Kashiwa (Bamboo shoot, Kashiwa leaf), Cascarilla, Cascaraca, Gypsophila, Gypsophila, Crab (Kinshato), Kaniwa, Carnation, Valerian (Valentine Root), Hippopotamus, Birch or Weeping Birch (White Birch), Gerbera, Pumpkin, Kapok'Noki "Seeds", Kahoku Salamander (Garden), Gama (Camellia), Chamomile or Roman Chamomile, chamomile (weed), cam cam (camo duck), carraguwa or yamagwa (mulberry camellia), color, chrysanthemum salmon, crow cucumber or cinnamon crow (king moth), crow bisha (Half-summer), oats, guarana `` seed '', calahoo (kokubaku), karaya, garyu, karin (garden), garcinia, kawamidori, kawara-cho (commissioned greens, white-billed grass), kawajisha, kawaratake, kawaranadeshiko (stone bamboo) ) Or Ezokawaranadeshiko (buckwheat noodles, buckwheat), Chinese carrots (blue ラ), Chinese mugwort (、 蒿 蒿), Kansui (sweet candy), licorice (licorice), Kantaraasa, Candelilla, Kantou, Kanna, kanran, raspberry (Ezo strawberry, Dutch Strawberry, Shrimp Strawberry, Narrow White Strawberry, Momiji Strawberry, European Yellow Strawberry), Kiwi `` Fruits, Leaves '', Kikarasuuri (Gurone), Chrysanthemum (Kikyo, Kikyo Root), Chrysanthemum (Chrysanthemum, Zebra Flower, Ginseng), Kikutaniku, Kisage ( (Fruit), scallop (sheep), pheasant (fruit), kizuta, yellow aloe vera, yellow mint, kina, linden ( , Quinoa, quinoa, yellowfin, yellow bean, gymnema sylvesta, kimenkaku, cabbage, cabbage `` immature fruit '', caraway, cucumber, gyory (Nishikawa willow, taro willow), kiraja saponaria, kiraya , Kiran Sou (Kinza Kosaku), Kumquat `` Fruit '', Kinkiju, Ginsekai, Kimbusen, Kinma, Kimihiki (Sentsukakusa), Kinran, Ginlan, Kinryohen, Guapaba Vermelya, Guava `` Fruit '', Guayule, Quercus Infectria ), Kukui nuts, kugenumaran, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, earth bone bark), cedar kazura (Tenmon winter), kudzu (kudzu root), camphor tree, gooseberry `` fruit '', ginseng (yellow flower buds), cutiti river , Gardenia (mountain lion), kunugi (bowl saw), kupuasu, kubeba, bear Saury, pine moth (horse whip grass), Clara (bitter), cranberry "fruit", chestnut "seed, fruit, astringent skin", curk crifo latifolia "fruit", grapefruit "fruit and leaf", buckthorn, black scabbard (emergency) , Kamebahikokoshi or kurobanahikikoshi or hikikoshi (prolongation grass), clove (clove, clove), gumba nazuna (sekimei, budgerigar), keigai (butterfly, cocoon), celosia (chicken flower, henko), gekkavidin, bay bay (laurel tree), Kenashi Sartorii rose (earthen soil, mountain return), Gentiana, Gennoshouko (Oldgrass grass), Kemponashi (Kigushi), Kokisekoku, Kushimikan (Koji, Tachibana, Obenimikan, Fuclican, Sagamikouji, Ponkan, Santara (Tachibana bark)), Koshinbara (Monthly flowers), Kousuihakka, Kozo `` fruit '', kocha (red) ), Kohone (river bone), Kohon (Tsubakimoto, Karamotomoto), Koryang, Kouryokyo (Koryoen), Cilantro (fruit), Kouren (Huo Ren), Koganebana (Yellow Gon), Cowberry (Koshibana), Coco '', Goshuyu (Kureo), Gosho Strawberry (Pepper), Pepper (Pepper), Cosmos, Copaiba Balsam, Coffee `` Seeds, Leaves '', Kobushi or Mokuren (Cotton), Burdock (Beef Bowl, Beef Eggplant), Kobotan, Sesame ( Sesame seeds, sesame seeds (genus ginseng), trash beetle (gomi), sakanekazura or binankazura or pine bush, wheat (wheat), rice or rice bran `` red potato, white birch '', rice oil, cola acminata `` seed '', cola vera `` seed '' ”, Colonyella, Koroha“ fruit ”, Colombo, Konzlango, Kombu, Konjac, Comfrey (Changzhou), Sisal (Sisal Asa), Sai Hairan, Sakaneran (Ezo) Canelan), saxifrage leopard or synaptic leopard or cinnabar prunus (weikensen), cherry (Oshima cherry, Yamazakura, Oyama cherry, edhigashi, bean cherry, Miyazakura, Yoshino cherry, Takanezakura, Kasamisakura, Kogan, Satozakura, leaves, flowers, leaves Bark (cherry bark) ''), cherry, pomegranate, Sasa, Sasabagin orchid, sasanka, sardine sardine (Sawamata), sweet potato, sugarcane, sugar beet, sunflower jujube (acid vine), saffron (Bansai flower, West Safflower), sapodilla, sapote mariyo, pomelo `` Fruit '', Sabonso, Salmon berry `` Fruit '', Sarasinashouma (Hemp), Salamander (Sandai sashimi), Salvia (Sage), Sagaki (Chinese curry), Sawagurumi (Yamako), Sangaku cactus, Sangre de Grado (Croton), Sanshi Carrot, Sansino carrot (37 ginseng), Sansyu (Yamazou), Sansho (Yamamuro), Sandskon (Yamazune), Shia (Kalite), Cyanoki "fruit", Shiitake mushroom (Shitake), Shion (Purple) , Jikitarisu, shikunshi (messy prince), perilla or blue mushroom or chimmen dizo or catamendizo (purple leaf, purple shiko), rosewood, linden tree, cinnamon onion, syringen (ream), shimeji (hinshimeji, shakashimeji, hatake shimeji, oshima shimeji, beech shimeji , Shirotamogitake), Shimokuren (hot potato), Shimotsukeso, Potato, Peonies (Shakuyaku), Shajin (Shasan), Jasmine (Matsurika), Janohige (Bakumon winter), Dwarf cowpea, Shukukonkamisou, Shukushamitsu (Sanjin) , Shredded sand), juzudama, palm "fruit", shung lan, jujuu palm, show (Ginger), Zodiac hydrangea (Tsuneyama), Shobu (bamboo shoot, Sone), Shozu `` fruit '', Shirakashi `` Seeds '', Silane (Bikkyu), Shirogori `` Seeds '', White clover (Clover), White clover (chicken bone grass) , White squirrels (smoke squirrels), Shirobanatsuta "flowers", Shirobana Lupine, Shirominanten (southern Tenmi), Cinconacylbra, Ginkgo biloba (Mizuka, Suzuka, Senncho), Cinnamon, Cinnamomum cassia (Kaishin), Suika , Honeysuckle (gold and silver flowers, Shinobu), Sorrel (Acid), Swimberry "Fruit", Star Apple, Stevia, Strawberry "Fruit", Tin Psycho (Xu Longan), Sugina (Question), Subuhiyu (Horse tooth soap, Horse tooth soap Child), plum "fruit", sulgaran (oran), Japanese red pine "ball cone", Japanese larch, Japanese kizuta, Japanese seiyo Walnut, hawthorn, cypress, dandelion, horse chestnut (maronier), pear `` fruit '', sunflower, elder, scallop (juniper, pine), yarrow (milfoil), rose, antelope Japanese butterfly, Japanese mistletoe, American mint or Atlantic mint Sarcophagus), cedron (bow squirrel), mallow, hiroha senega, senega, seri, celery, nematode (river cucumber), senshinren (pure ream), sendan, sennin cactus, Nanna `` fruit, leaf '', ginseng (daikon), sea bream (medicated), senboku, soka (grass), elephant chrysanthemum, prawns, buckwheat `` seed '', potato monogram, broad bean, daiou (daihuang), radish, soybean, daidai (Orange peel, fruit), Takasago Gurihigotai (Southeast Indigo Sashimi), Takasaburo (Cirrus Lotus), Takatodai (Oyodo), Takarabi (Cirrus spine), Dark Sweet Cherry `` Fruit '', Japanese hollyhock, Tachikoso (Time, Hundred incense), Tachidokoro (Hikai), Tachiyanagi, Tamarind `` Seeds '', Onion, Tamshiba (hot pepper), Taranoki `` Fruits, leaves, root bark '', Tarayo (Large winter blue, Ichiha tea, bitter tea, bitter tea), Dahlia (Tenjiku button), Tarwi, Tankimi, Tanshiwiwa, Tanjin (Tanjin), Dandelion (Sanko) or Shirobana Dandelion or Mouko Dandelion, Danmaru, Cherry , Tigaya `` fruit, root, bud '', Chixetsu carrot (Bamboo ginseng), chicory, Chunky Piedra (Kidachikokansando), tulip, chokonostay, Datura (Artichoke), Dendrobium (Daido), Datura ), Korean mugwort (bamboo leaves), choreimaitake (bamboo shoots), chorogi, camellia, tsukushikaneran, tsukuritake (mushrooms), azalea, camellia, camellia, clover (lacquered licorice), camellia (duck moth), red azuki (red red beans) ), Tsurutsuchiakebi, Tsurudokudami (What a crab), Tsuruna (Apricot), Tsuru carrot (Yotsuba ginseng), Tsurume, Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tengusa, Tencha (甜茶), Tendaiyaku (glaze), Toga ( (Winter Lion), Capsicum, Capsicum (Pan), Toki (Today), Tokinkinka (Marigold), towed beak, tounabena (river cut), towed rattle (Sadako), torindo or chosenrindo (dragon gall), toksa (wood bandits), dokudami (ten drugs), tokon (pig root), tochu ( Bark, leaves, roots ''), ash (crusts), tomatoes, tragacanth, triacanthus `` seeds '', eustoma, tormentilla, dronoki, troro-aoi, tongamame, nigerian berry `` fruit '', yam or yam (mountain medicine), nagii-kada ( Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Natsume or Natehaki (Sword Bean), Natsumikan, Jujube (Otsuchi), Naniwaibara (Golden Cherry), Navena (Suspended), Nameko, Nankin Bean (Peanut), Nanten (Southern Fruit) ), Namban Karamushi (Hemp), Nio-Ismille, Nigaki (Nakiki), Nigamugi (Anguish), Nikuzuku, Kei or Nikkei or Se Iron Nikkei or Yab Nikkei (Cinnamon bark) or Keishi (Keishi branch), Flying tiger plover, leek (lion), elderberry (bone, `` fruit, flower, stem, leaf ''), garlic (large persimmon), Nurde (penta), leek, nemonoki Or Nebu or Nebi or Nemurino or Digokubana (community), Noazami (Daisetsu), Nobara (Natural), Nozenkazura (Lingen Flower), Nogateto, Yarrow, Nodake (Maehu), Novara, Peach, Pineapple `` Fruit '', Hibiscus (Busouge) , Fulinbussouge, Roselle), Hailindo, Hauchiwa, Pau Dorse, Hakama Labosi (osteostomy), Hakukayumatou, Chinese cabbage, Chinese cabbage (white tinea), Hakulberry `` fruit '', Japanese crocodile (breeding), Habami (coconut), Hasidorokoro (Roof root), basil, lotus (lotus, lotus meat, lotus), parsley (holland jellies), hadakamugi, batata, bee or Dake (bamboo shoots), patchouli, peppermint (light load, light load leaf), yellow peas, yellow barley (Yokuinin), Hanasuge (my mother), bananas, hanahakka, Hanabishi (Sitsurishi, Shitsutsuri), vanilla bins, papaya, scallops , Pahalobobo, hub `` whole grass, stem, leaf '', paprika, oysters, hamago or honey bee (Vulgaris), hamasge (Katsukiko), Hamabishi (Shitsuko), Hamanasu (Maikai flower), hamabofu (hamafufu), Hamamelis, palm, rose (rose), balata, balata rubber tree, agaric (agaric, white-faced agaric, quince) (Skin, maple leaves), Barbasco, Harlindow, Handaikai (Taikai Sea), breadfruit, Sea bream (shallow dried), lizard carrot (participant), pecan nut, ganbanana (stone wall, vine pearl flower), Higuruma dahlia, higotai, Japanese horsetail (hishin), pistachio, beet, human head (stone wall), human winged fern, daisies (Daisy), Hinata Taikozuchi (cow knee), chickweed, cypress, hiba, castor, sunflower, bell pepper, Himezu (Tengu), Himamatsu (Kaori), Himematsutake (Kawariharatake, Hiromatsutake), Himemuyoran, Pimenta `` fruit '', Beakshi, beakkyu, jade "fruit", chickpea, lentil, bellowed oyster, hirohaokinagusa (bald eagle), loquat "fruit, leaf, stem", betel nut (large clothes skin, coconut), puer tea (common tea), sweet pod (Southern rattan), Japanese cypress, Japanese cypress poppo (Section winter flowers, Sectonic winter leaves), Fujibakama (Orchid grass), Fuji bean (Tsuname), Fujimodoki (Chujizakura, Flowers), grapes `` fruits, pericarps, seeds, leaves '', beech, Fuyumushinatsusatake (Cycium Cordyceps), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant coconut, black currant `` fruit '', blackberry, Branjen, Plum `` Fruits '', Fruceraria, Blueberries (Prunus apricots), Prunes, Floral Blanca, Blond Psyllium, Bundou (Mung Beans), Hazelnuts, Loofah, Hetsukaran, Safflower (Safflower), Heneken, Belladonna, Berry `` Fruits '', Percea, Pervian Berg, Pereschia grandifolia, red beetle or Ixusa (scenic sky), Boysenberry `` fruit '', Bakigi or Niwaxa or Nendo or Hahagaki Kokia (silk), Hausairan, Dendrobium (Daffodil, Acute pupa, Periosteus), POWTERIA SUPOTA, PO Uteria Lukuma, spinach, spinach, physalis (Torone), honoki (Japanese welfare, magnolia), bokeh (wooden moss), hosobaaragiku (painful), hosobaoguruma, hosobananakera (蒼朮), hosobanokirinso (37 ), Hosobabarengiku, Bodaiju (bamboo tree), buttons (peony `` flowers, leaves, stems, bark ''), buttonpi (peony skin), hops, jojoba, borage (Lulichisha), Bordeaux, water berry `` fruit '', hononiku ( Meat jugo, Daige), Honsekoku (Iron skin stone, Sparrow mountain stone mackerel), Mizurutennansho (Tennan star), Maitake (Maiko), Maou (mao), Maca, Macadamia nut, Margaret (Mokushungiku), Macri ( (Aquatic grass), Magwa (mulberry bark `` bark, leaf ''), Magnolia splengeri, Mazaran saba, Masaransuba de Cearah, Masheira de Boi, Mashua (Tama Nozenhalen, Kyukonkinrenka), Matatabi (wood Tendon), Matsukasa, pine `` leaves, bark, root '', Matta Orillo, Matsuhodo (Matsuhodo), Matico (Cordon Shijo), Mayoram (Hanahakka), Malvanojajin (Tansen), Mulberry `` fruit '', quince, malein (biloudomozuika), mango, mangosteen, manzanya (andesuka mitsule), manshu gurumi, mandarin `` fruit '', garlic mushroom (reishi), pheasant (fruit berry `` fruit ''), mishima psych (shiba-ko) ), Mizusobako or Mizuasagao (Drugosa), Mizokakushi (half-sided lotus), Misohagi (Chinese cucumber), Michiyanagi or Niwayanagi (Henpotsu), Mitsuwashi, Mitsuba, Midori Zapote, Mirihakka, Mimosa, Mioga, Miracle Fruit `` Fruit '' , Myrrh, myrbaran, wheat straw, mugweed (mushroom), myrtle, mukuroji (Life-prolonging skin), munya, purple (purple), purple or blue purple (purple pearl), purple cherry (Kunming chicken blood wisteria), megakansa opuntica, pheasant (benus), melodygi, evening primrose, melaroica, melissa , Merirot, Melon `` fruit '', Moukomomogi, Mosouchiku, Mokukirin, Mogi (Pepper), Ichinoki, Mokko (woody incense), Momijidaio, Peach (peach `` leaves, seeds, flowers, fruit ''), coconut, Morello cherry `` Fruit '', Morohaya (burlap), Yakawamurasakimo, Yakuchi (Michichi), cornflower (cornflower), cornflower mint, yacon, yachabushi or himeyashabushi `` fruit, pericarp, fruit ear '', yachiyanagi, yatsude (Octagonal gold plate), mistletoe (willow infestation), willow (kawayanagi, tachiyanagi, weeping willow) Giant, Red Willow, Pussy Willow, Incolyana, Kinu Willow, Collagenagi, Unryu Willow, Miyayanagi, Palm, Yamanagi, Obayanagi, Tairiku Kinuyanagi, Foxwood Willow, Tobacco, Tobacco, Beef虱, Tenmeisei), pokeweed (commercial land), Yamahanoki (Yamabuchi), bayberry (Plum skin), sagebrush, eucalyptus, saxifrage (tiger ear grass), yucca or flavifolia, yuzu `` fruit '', lily, sagebrush, mugwort (Bamboo leaves), Ligan (Raimaru), Lime `` fruit '', Rye, Lacanca `` Fruit '', Raspberry `` Leaf, fruit '', Latania (Clamelia), Lackey or shallot (palm white), Lavender, Longan (long-eye meat), Agave ( Aono Agave, Fukurin Agave), Ryokucha ( Tea), apple `` fruits, seeds, leaves, roots '', gentian, lubas or suabishimusu (bool), rulitama thisami (bladder higotai, shinjiai sashimi), litchi (toothpick, toothpick core), lettuce (chisha), red Currant `` Fruit '', Red Pitaya, Lemon `` Fruit '', Lemongrass, Forsythia or Chinese Forsythia (ream), Forsythia, Wintersweet, Wayashi, Lokon (Yoshi, Sone), Loganberry `` Fruit '', Rosemary ( Mannenrou), Rosehip (Nobara), Wasabi, Watafujitsugi (Mitsumona), Waremokkou (Earth).

  As seaweeds, seaweed [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), seaweed [Brown algae] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Neocitus Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etuki Umi Uchiwa], seaweed [Red Algae: Hijirimen, Maca (Tengusa), Hiluxa, Syria, Oaxa Caterpillar, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper ginkgo rhinoceros, Tsunomata, Totsuka (Yahazutsu notamata), Ezotsunotamata, Togetu no Takita , Yaleus banori, Kagius banori, Susius banori, Haius banori, Akamo mizunori] and the like.

  Other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kuwanomimo: Kuwanomimo, Volbox: Dandelion, Volbox, Palmera, Yotsumeo, Himidori Aoumiduro, Tsurugidomiro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa : Magatama, Dioscorea: Pheasantata, Surichogita, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hiramil Casanori: Casanori, Jusmo: Jujusmo, Tamajusmo, Mizojusmo, Mika ヅ kimo, Korekaete, Tsutsumimo, Kikkogusa, Humanexa : Sumiremo, Hosimidro, Fuchinashimidro etc.).

  Cyanobacteria (Suizenjinori genus: Suizenjinori, Aoko genus, Nenjumo genus: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.).

  Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozu, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: iwahige, yokojimamanori: Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Genus Ukimo: Ouokimo, genus Burukimo: burukimo, genus Kayamonori, etc.).

Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Proboscis: Giant plover, Hytengus, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashkarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobasho: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haezaki Sawflower, Kawamoku : Kawamoke, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okichizu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).

  Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotamnus, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.

  Animal raw material-derived materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or degradation product thereof, cow or pig brain tissue extraction Collagen hydrolyzate (acid, alkali, enzyme, etc.) of products, cattle / pigs or fish, collagen derivatives such as water-soluble collagen or acylated collagen, bovine or pig elastin or elastin hydrolyzate (acid, alkali, enzyme, etc.) ) Or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or cow blood cell protein degradation product (globin peptide), cow or pig hemoglobin degradation product (hemin) Hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof or derivatives thereof, skim milk powder and degradation products thereof or derivatives thereof Lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.

  As a material derived from these plant or animal materials, any site, cell, tissue, organ, metabolite, etc. derived from a gene recombinant or a cell fusion can also be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.

(14) Seawater such as deep seawater, such as sea salt, dried seawater, dead sea or Atlantic or Pacific seawater (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud ( (Fango), for example, Italian mugo, German fungo, Eifelfango, Freiburg fungo, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, Magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, black meteorite, etc.

(15) Microbial culture metabolite yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermentation extract , Fermented extract of rice bran (red rice bran, white rice bran), Euglena extract or decomposition product thereof or water-soluble derivatives thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, lactic acid bacteria fermentation product of legumes, coconut plant Lactic acid bacteria fermented products.

(16) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, Bengala, black iron oxide, gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.

(18) UV absorber / blocker benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxy Dimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, Octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxycinnamic paracinnamic acid) Til, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, Methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative , Umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin, etc. .

(19) whitening agent paraaminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or its derivatives, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, pearl oyster, walrus, clam, mugwort, honeysuckle) , Kihada, dokudami, matsuhod, pearl barley, nettle, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamamelis, karagua or yamagwa, life-prolonging grass, bellflower, sequel, gyoza, mao, senkyu, de Katsu, Psycho, Bowfu, Hamaboufu, Ogon, Peony skin, Peonies, Gennoshouko, Kuzune, Licorice, Pyrup, Aloe, Shouma, Safflower, Green tea, Black tea, Asen)

(21) Melanin pigment reduction / decomposition substance phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether).

(22) Turnover promoting action / cell activation substance hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, Ogon, Japanese horsetail, Gentian, Burdock, Shikon, Carrot, Camelis, Hop, Yokuinin, Odori, Semburi, Japanese cypress, Japanese red snapper, Achacha, Hypericum, Cucumber, Red-headed ginger, Mannenrou, Parsley).

(23) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds) and the like.

(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidant vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole , Propyl gallate, sesamol, sesamorin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame culture cells, hamcha, hypericum, hamamelis, clove, melissa, enamel, birch, salvia, mannenro, minamitenji, ginkgo, green tea).

(27) Anti-inflammatory agent ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its Salt, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract, propolis, etc.

(28) Antibacterial / bactericidal / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, Sarashi flour, iodine compound, iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p -Chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ester Diol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benzalkco chloride) Nium, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal bio Tsu DOO, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.

(29) Moisturizer glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid (α-hydroxy acid), hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, water-soluble chitin or Derivatives or chitosan derivatives, pyrrolidone carboxylic acid or salts thereof, sodium lactate, urea, sorbitol, amino acids or derivatives thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates, Phosphate, nitrate, citrate, or pyrrolidone carboxylic acid), oils and fats “Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil Cucumber oil, beef tallow fatty acid, quince seed oil, cucumber seed oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil , Turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mole oil, palm oil, eucalyptus oil, beef tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (cured oil) ”, Waxes (beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lano , Candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), natto fungal metabolites, natto extract, silk fiber extract, plant extract (red pine sap) , Aloe, kudzu root, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assembly, mulberry white bark, persimmon leaves, loofah, peony skin, persimmon), etc.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ogon, Hypericum, Clara, Mulberry leaves, Keihi, Gennosho, Comfrey, Salvia, Elderberry, Bodaiju, Buttonpi), seaweed extract and the like.

(31) Hair selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, thio Glycolic acid and the like.

(32) Antiandrogen follicular hormone (estrone, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral blood flow promoter Vitamin E or its derivatives, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, pearl extract, cephalanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants chili tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitive element 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(36) Antiseborrheic agent pyridoxine or a derivative thereof, sulfur, vitamin B6 and the like.

(37) The keratolytic agent resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, Sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(39) Hair removal agents Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate) Strontium thioglycolate) and the like.

(40) Hair swelling agents such as ethanolamine, urea and guanidine.

(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, paraphenylenediamine, paramethylamino Phenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N -Phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diamino sulfate Diphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, parasulfate sulfate Methylaminophenol, metaaminosulfate Diol, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfone Sodium acid, hematein, etc.

(42) Fragrance Natural animal fragrances such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, Cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot Essential oil , Peru balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannenrou) essential oil, Japanese mint mint essential oil Other synthetic fragrances.

(43) Dye and Colorant Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye, Onion Dye , Tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.

(44) Other hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and vegetable polysaccharides And its degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound treatment agents, foam-increasing agents, thickeners, enzymes, purified water (electronic Water, small clustering, etc.), oral preparations, deodorizing / deodorizing agents, bittering agents, etc. are raised, and by using these in combination, the effect of the present invention or other cosmetic effects can be additively or synergistically improved. I can expect.

  In addition, about the method of addition to the melanin production inhibitor of this invention or cosmetics composition, it may add previously, may be added in the middle of manufacture, and should just select it in view of workability | operativity.

  Hereinafter, production examples, test examples, and formulation examples will be described, but the present invention is not limited thereto.

(Production Example 1)
100g of various dried plants of Salacia reticulata, Salacia chinensis and Salacia oblonga are heated and extracted with purified water (about 80 ° C) for about 5 hours, filtered and extracted (dry solid content: about 0.1-3.0%) You get about 1.0kg.

(Production Example 2)
100 g of various dried plants of Salacia reticulata, Salacia chinensis and Salacia oblonga are immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, filtered and extracted (dry solid content: about 0.1 to 3.0%) Get about 1.0kg.

(Production Example 3)
100 g of dried plant excluding Salacia reticulate, also known as Kothalahimbutu roots and leaves, in 70% ethanol solution or 70% 1,3-butylene glycol solution, or 60% propylene glycol solution, or purified water After immersion in (about 60 ° C.), extraction at room temperature for 5 days and nights, filtration is performed to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 3.0%)

(Test 1) Test for inhibiting melanin production “Test method and evaluation method”
B16 melanoma cells were cultured for 24 hours, and this culture medium was replaced with a culture medium to which a sample was added. At this time, purified water was added to the blank. After culturing for 3 days, the cells were treated with trypsin, heated and dissolved in a 1N-NaOH solution containing 10% DMSO, and the absorbance at 420 nm was measured. At the same time, the number of cells was measured by the MTT reduction method (Tim Mosmann; see Journal of Immunological Methods p55-63 (1983)). The inhibition rate (%) with respect to the amount of melanin produced by the cells was determined by Equation 1. The results are shown in FIG.

"sample"
The melanin production suppression test sample was subjected to the test using various plant extracts (solid content concentration: adjusted to 0.0025%) obtained in Production Examples 1 to 3 of the present invention. As a comparative sample, arbutin (manufactured by Sigma) was prepared under the same conditions and used for the test.

<Equation 1>
Melanin production inhibition rate (%) = {1- (sample melanin amount / blank melanin amount)} × 100

(Test results)
As shown in FIG. 1, various plant extracts of Salacia reticulata, Salacia chinensis and Salacia oblonga of the present invention can be confirmed to have almost the same melanin production inhibitory action as arbutin, and can be used as a whitening agent. .

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared so that the solid concentration was about 1.0%, and this was Hartley shaved on the back. 0.03 mL was applied to each 2 × 2 cm 2 square of the skin of a system guinea pig (female, 3 mice per group, body weight 300 to 350 g). Judgment was performed 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indicators. As a result, in all animals, no erythema and edema were observed, and it was judged negative.

(2) Cumulative skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared so that the solid concentration was about 1.0%, and the Hartley system was obtained by shaving the flank (2 × 4 cm2). The skin of guinea pigs (female, 3 mice per group, body weight around 320 g) was applied once a day, 5 times a week, 0.5 mL / per animal. Application was for 2 weeks, and shaving was performed on the last application day of each week. Judgment was made on the day of each application and the day after the last application by the scoring method of primary irritation using erythema and edema as indices. As a result, in all animals, no erythema and edema were observed for 2 weeks after application, and it was judged negative.

(3) Single-dose toxicity test Various plant extracts obtained in Production Examples 1 to 3 were adjusted to 12.5% with purified water and fasted for 16 hours per test for 16 hours before testing. Orally administered to a ddy strain mouse (male and female, 1 group, 5 mice, 5 weeks old) with a sonde, and the onset, degree, etc. of toxic symptoms were observed over time. As a result, no abnormalities were observed in all mice for 14 days, and no abnormalities were found in the anatomical results. Therefore, LD50 was 2,000 mg / kg or more, and was judged to be a safe substance.

Manufacture of various cosmetic compositions According to the above evaluation results, formulation examples are shown below. Each formulation example may be manufactured by a conventional method in manufacturing each product, and only the blending amount is shown. The present invention is not limited to these.

(Formulation Example 1) Milk Mass%
1.Squalane 5.0

2.Olive oil 5.0

3. Jojoba oil 5.0

4.Cetyl alcohol 1.5

5. Glycerin monostearate 2.0

6.Polyoxyethylene (20) cetyl ether 3.0

7. Polyoxyethylene (20) soorbitan monooleate 2.0

8.1,3-Butylene glycol 1.0

9.Glycerin 2.0

10. Various plant extracts from Production Example 1 5.0

11. Preservative (paraoxybenzoic acid ester) appropriate amount
12.Perfume appropriate amount
13. Residue with 100 purified water

(Formulation Example 2) Milk Mass%
1. Squalane 8.0

2. Jojoba oil 7.0

3.Glyceryl paraaminobenzoate 1.0

4.ethyl urocanate 1.0

5. Vitamin C phosphate magnesium salt 1.0

6.Cetyl alcohol 1.5

7. Glycerin monostearate 2.0

8.Polyoxyethylene (20) cetyl ether 3.0

9.Polyoxyethylene (20) soorbitan monooleate 2.0

10.1,3-Butylene glycol 1.0

11.Glycerin 2.0

12.1,2-Pentanediol 3.0

13. Salacia chinensis extract from Production Example 5.0
14. Prunus water extract
1.0
15.Yaba Santa water extract 1.0

16. Ivy leaves or stem 70% ethanol extract 1.0

17. Hypericum leaf or stem 70% ethanol extract 1.0

18. Murasaki (purple) root 50% propylene glycol extract 1.0

19. Silk Protein Enzyme Degradation Solution 1.0

20. Pig placenta water extract 1.0

21. Appropriate amount of antibacterial and antiseptic (paraoxybenzoic acid ester)
22.Residue with 100 purified water

(Formulation Example 3) Cosmetic Oil Mass%
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Salacia oblonga extract from Production Example 2 5.0
6.Nenshikazura hot water extract 3.0

7. Grapefruit fruit or leaf hot water extract 1.0

8. Mulberry leaf or bark hot water extract 1.0

9. Soybean seed hot water extract 1.0

10.Olive oil 1.0

11. Shea fat 1.0

12.Butylhydroxyanisole 0.1

13. Vitamin E derivative 0.1

14. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
15. Perfume (rose water) appropriate amount
16.Residue with 100 purified water

(Formulation example 4) Flexible lotion mass%
1.Glycerin 5.0

2.1,3-Butylene glycol 5.0

3. Monolauric acid polyoxyethylene sorbitan (20E.O) 1.0
4.Ethanol 15.0
5. Salacia reticulata extract from Production Example 5.0
6. Ivy leaves or roots 60% 1,3-butylene glycol extract 1.0

7. Chamomile whole plant 60% 1,2-pentanediol extract 1.0

8. Bodhi tree flower or fruit 50% 1,3-butylene glycol extract 1.0

9. Eggplant 30% ethanol extract 1.0

10. Ginger fruit or root 30% 1,2-pentanediol extract 1.0

11. Kiwi fruit 50% ethanol extract 1.0

12. Antibacterial (Lactoferrin solution) appropriate amount
13. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
14. Fragrance (Western light load water) appropriate amount
15. Residue with 100 purified water

(Formulation Example 5) Astringent lotion
1.Sorbit 2.0

2. POE (20) oleyl alcohol 1.0

3.Ethanol 15.0
4.1,2-Pentanediol 3.0

5. Salacia reticulata extract of Production Example 3 5.0
6. 50% propylene glycol extract of coconut krill leaves or fruits 2.0

7. Clove flower or cocoon 30% ethanol extract 2.0

8. 50% 1,3-butylene glycol extract from sorghum leaves 2.0

9. Gentian whole plant 50% ethanol extract 2.0

10. Camelis leaf or bark 50% 1,3-butylene glycol extract 1.0

11.Yamakatsu peel or fruit 30% ethanol extract 1.0

12. Yeast 50% 1,3-butylene glycol extract 1.0

13. Allantoin 0.2

14. Astringent (Zinc Sulfocolate) 0.2

15. Antibacterial and antiseptic (thiamin lauryl sulfate) appropriate amount
16. Fragrance (lavender water) appropriate amount
17.Residue with 100 purified water

(Prescription Example 6) Two-layer lotion (liquid to liquid type)
1. Squalane 8.0

2. POE sorbitan tetraoleate 0.3
3. Sorbitol 1.0

4.Ethanol 15.0
5. Salacia reticulata extract of Production Example 3 5.0
6.Lily flower or head flower 70% 1,2-pentanediol extract 3.0

7. Rhizome or root bark 60% 1,2-pentanediol extract 2.0

8. Oolong tea leaves or stems 70% ethanol extract 2.0

9. Avocado fruit or root 50% propylene glycol extract 2.0

10. Coffee bean or seed 50% 1,3-butylene glycol extract 2.0

11. Sage whole plant 50% ethanol extract 1.0

12. Western bodhi tree flower or fruit 30% ethanol extract 1.0

13.Ascorbic acid glucoside 0.2

14. Astringent (calamine) 0.1

15. Antibacterial / preservative (phenoxyethanol)
16. Fragrance (camomile water) appropriate amount
17.Residue with 100 purified water

(Formulation example 7) Carmine lotion (liquid to solid type)
1.Glycerin 3.0

2.1,3-Butylene glycol 5.0

3.Ethanol 15.0
4. Iron oxide (Bengara) 0.2

5.Zinc oxide 0.5

6.Kaolin 2.0

7. Salacia chinensis extract from Production Example 5.0
8.Lily flower 50% propylene glycol extract 3.0

9. 50% Propylene Glycol Extract from Co button Kale Seed 2.0

10. Shark root 50% propylene glycol extract 2.0

11. Usvenia mallow flower or leaf 50% propylene glycol extract 2.0

12. Barley seed or fruit 50% propylene glycol extract 2.0

13. Comfrey leaves and stems 50% ethanol extract 1.0

14. Fuquidan popo flower or leaf 50% 1,3-butylene glycol extract 1.0

15. Porcine placenta enzymatic solution 1.0

16. Silk protein alkaline solution 2.0

17.Camphor 0.2

18.Phenol 0.03

19. Antibacterial and antiseptic (photosensitive element 201 & 401) appropriate amount
20. Fragrance (Bodhi Tree Water)
21. The balance of 100 purified water

(Formulation example 8) Pack mass%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0

3.Propylene glycol 3.0

4.Ethanol 10.0
5. Salacia oblonga extract from Production Example 2 5.0
6. Ginseng root 30% ethanol extract 1.0

7. Stem or leaf 30% ethanol extract 1.0

8. Wenzhou tangerine peel 50% 1,3-butylene glycol extract 1.0

9. Green tea leaf or stem hot water extract 1.0

10. Peach leaf or stem hot water extract 1.0

11. Yeast 50% 1,3-butylene glycol extract 1.0

12. Pig placenta hot water extract 1.0

13. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
14. Fragrance (rose water) appropriate amount
15. Residue with 100 purified water

(Formulation example 9) Peel-off pack mass%
1.Glycerin 5.0

2.Propylene glycol 4.0

3.Polyvinyl alcohol 15.0
4.Ethanol 8.0

5.Polyoxyethylene glycol 1.0

6. Pantothenyl ethyl ether 1.0

7. Salacia reticulata extract from Production Example 2 5.0
8. Papaya whole plant 50% glycerin extract 3.0

9. Safflower whole plant 50% ethanol extract 1.0

10. Dutch Jelly (Parsley) Leaf or Stem 50% Ethanol Extract 1.0

11. Eucalyptus leaf or stem 30% ethanol extract 1.0

12. Royal jelly 50% ethanol extract 1.0

13. Trehalose solution 1.0

14. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
15. Fragrance (Karashi Water) Appropriate amount
16.Residue with 100 purified water

(Prescription Example 10) Cold cream mass%
1. Sarah Beeswax 11.0
2.liquid paraffin 22.0
3.Lanoline 10.0
4.Olive oil 5.0

5. Ylang Ylang Oil 5.0

6. Palm oil 5.0

7.borax 0.5

8. Salacia reticulata extract from Production Example 3 5.0
9. Achillea millefolium whole plant extract 2.0

(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
10.White birch bark extract 2.0

(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
11. Ginseng root 50% propylene glycol extract 2.0

12. Matsuhodo nuclei 50% 1,2-butylene glycol extract 1.0

13. Soybean seed water extract 1.0

14.Zinc yeast 50% 1,3-butylene glycol extract 1.0

15.Liquid shea fat 1.0

16.Dipotassium glycyrrhizinate 0.1

17. Antibacterial and antiseptic (Acrinol) 0.1

18. Perfume (ylang ylang water) appropriate amount
19.Residue with 100 purified water

(Formulation example 11) Emollient cream mass%
1.Stearic acid 2.0

2. Stearyl alcohol 7.0

3.Reduced lanolin 2.0

4.Squalane 5.0

5. Octyldodecanol 6.0

6. Polyoxyethylene cetyl ether (25E.O.) 3.0

7. Lipophilic glyceryl monostearate 2.0

8.Propylene glycol 2.0

9.1,2-Pentanediol 2.0

10. Salacia chinensis extract from Production Example 1 5.0
11. Corn flower 50% dipropylene glycol extract 2.0

12. Shiso leaf 50% propylene glycol extract 2.0

13. Murasaki (purple) root 50% propylene glycol extract 2.0

14. Soybean seed natto fermentation liquid 1.0

15.Glycyrrhetinic acid 0.1

16. Porcine Placenta Enzymatic Decomposition Solution 1.0

17. Antibacterial (Lactoferrin solution) 0.5

18. Antibacterial and antiseptic (zinc pyridione) appropriate amount
19. Fragrance (mugwort water) appropriate amount
20.Residue with 100 purified water

(Formulation example 12) Facial cleansing cream mass%
1.Myristic acid 25.0
2.Stearic acid 5.0

3. Tallow fatty acid 5.0

4.Propylene glycol 10.0
5.Potassium hydroxide 6.0

6. Palm oil fatty acid diethanolamide 6.0

7. Salacia oblonga extract from Production Example 1 5.0
8.Corn extract 2.0
9.Lily extract
2.0

10. Apple fruit 20% 1,3-butylene glycol extract 1.0

11. Rosehip fruit 30% ethanol extract 1.0

12.Kakkon hot water extract 1.0

13. Burdock root 50% 1,3-butylene glycol extract 1.0

14.Glycyrrhizic acid 1.0

15.Apricot kernel 0.1

16. Walnut shell grain 0.1

17. Antibacterial and antiseptic (2-phenoxyethanol) 0.1

18. Perfume (today water) appropriate amount
19.Residue with 100 purified water

(Prescription Example 13) Face-wash cream%
1.Stearic acid 10.0
2.palmitic acid 10.0
3.Myristic acid 12.0
4.Lauric acid 4.0

5.Glycerin 18.0
6. dl-Pyrrolidonecarboxylate solution 1.0
7.Dioctyl adipate1.0

8.Cetostearyl alcohol 3.0

9.Triethanolamine 3.0

10.Ergocalcifer 1

11.Oleyl alcohol 1.5

12. Lanolin derivative (EO adduct) 1.0

13.Potassium hydroxide 6.0

14. Salacia oblonga extract from Production Example 2 5.0
15. Royal Jelly Extract 1.0

(Ethanol: 1,3-butylene glycol = 1: 1 extract)
16. Oil-soluble licorice root or rhizome extract 1.0

(Ethanol: 1,3-butylene glycol = 1: 1 extract)
17. Edetate 1.0

18.Glycyrrhizic acid 1.0

19.Teuchwalnut shell grain 0.1

20. Antibacterial and antiseptic (photosensitive element 401) 0.1

21. Fragrance (mugwort water) appropriate amount
22.Residue with 100 purified water

(Prescription Example 14) Body soap mass%
1.Potassium laurate 15.0
2.Potassium myristate 5.0

3.Propylene glycol 5.0

4.Alkanediol 1.0

5. Salacia reticulata extract of Production Example 3 5.0
6. Wakame and kelp 70% 1,3-butylene glycol extract 0.5

7. Achacha leaf or stem 70% 1,3-butylene glycol extract 0.5

8. Soybean seed natto fermentation liquid 0.5

9. Persimmon leaf 50% dipropylene glycol extract 0.5

10. Altea whole plant 60% dipropylene glycol extract 0.5

11. 20% 2,3-butyleneglycol extract solution

12.Aloe Flesh Flour 1.0

13.Polyethylene powder 0.5

14.Hydroxypropyl chitosan solution 0.5

15. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5

16.Monammonium glycyrrhizinate 0.1

17. Antibacterial / preservative (undecylenic acid, phenol)
18.pH adjuster
19. Perfume (lavender water) appropriate amount
20.Residue with 100 purified water

(Prescription Example 15) Body soap mass%
1.Potassium laurate 15.0
2.Potassium myristate 5.0

3.Propylene glycol 5.0

4. Salacia reticulata extract from Production Example 3 5.0
5. Corn flower 70% 2,3-butylene glycol extract 3.0

6. Toki rhizome 70% 2,3-butylene glycol extract 0.5

7. Kakkon 70% 1,3-butylene glycol extract 0.5

8. Nettle whole plant 70% 1,3-butylene glycol extract 0.5

9. Fish (salmon or flounder, salmon) derived hydrolyzed collagen solution 0.5

10. Plantain whole plant 50% ethanol extract 0.5

11. Amino acids (glutamine, proline, lysine, etc.) 0.5

12.Monoammonium glycyrrhizinate 0.1

13. Antibacterial / preservative (undecylenic acid, phenoxyethanol)
14.Adjustable pH adjuster
15. Fragrance (orange water) appropriate amount
16.Residue with 100 purified water

(Formulation Example 16) Sunscreen cosmetics (O / W type)
1.Oxybenzone 2.0

2.Octyl paramethoxycinnamate 5.0

3.Dihydroxymethoxybenzophenone 0.2

4.Squalane 10.0
5.Vaseline 5.0

6. Stearyl alcohol 3.0

7.Stearic acid 3.0

8. Glyceryl monostearate 2.0

9.Ethyl polyacrylate 1.0

10.1,3-Butylene glycol 6.0

11. Edetate disodium 0.1

12.Triethanolamine 1.0

13.Titanium dioxide 5.0

14. Yaba Santa seed or root 50% ethanol extract 3.0

15. Salacia reticulata extract from Production Example 2 5.0
16. Gentian whole plant 50% ethanol extract 1.0

17. Birch bark 70% dipropylene glycol extract 1.0

18. Cornflower leaf 50% propylene glycol extract 0.5

19. Kakkon 50% propylene glycol extract 0.5

20. Palm fruit 50% dipropylene glycol extract 0.5

21. Antibacterial and antiseptic (benzyl paraoxybenzoate) appropriate amount
22. Fragrance (jasmine water) appropriate amount
23. Residue with 100 purified water

(Formulation example 17) Sunscreen cosmetics (oil type)
1.liquid paraffin 70.0
2.Tetrahydroxybenzophenone 1.0

3.Cetyl octanoate 23.8
4. Salacia chinensis extract of Production Example 2 5.0
5. Orange peel or fruit 10% 1,3-butylene glycol extract 0.5

6. Burdock root hot water extract 0.5

7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5

8. Mallow flower or leaf 50% propyl alcohol extract 0.5

9. Whole barley 50% 1,3-butylene glycol extract 0.5

10. Shark root or leaf hot water extract 0.5

11.Merirot flower or leaf 70% 1,3-butylene glycol extract 0.5

12.Ethyl paraaminobenzoate 0.2

13. Antioxidant (Butylhydroxytoluene)
14. Perfume (amber perfume) appropriate amount

(Prescription Example 18) Cream foundation (O / W type) Mass%
1. Stearic acid 4.0

2.Glycerol monostearate3.0

3.Cetanol 1.5

4.Isopropyl myristate 7.0

5. Liquid paraffin 10.0
6. Sarah Beeswax 3.0

7.Triethanolamine 1.5

8.Glycerin 3.0

9. Bentonite 1.0

10.Titanium oxide 8.0

11.2,4-Dihydroxybenzophenone 8.0

12.Kaolin 3.0

13. Talc 3.0

14. Colored pigment (yellow iron oxide) 1.0

15. Salacia oblonga extract from Production Example 2
16.Lily flower 70% 1,2-pentanediol extract 1.0

17.Dokudami leaf hot water extract dry powder 0.3

18. Yukinoshita whole plant hot water extract dry powder 0.3

19. Persimmon rhizome or root bark 50% ethanol extract 0.3

20. Antibacterial and antiseptic (phenoxyethanol) 0.1

21. Fragrance (rose water) appropriate amount
22.Residue with 100 purified water

(Prescription Example 19) Shampoo Mass%
1.Lauryl sulfate triethanolamine 5.0

2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-Butylene glycol 4.0

4.Lauric acid diethanolamide 2.0

5. Edetate disodium 0.1

6. Salacia reticulata extract from Production Example 2 5.0
7. Large-scaled crape myrtle 20% 2,3-butylene glycol extract 2.0

8.Hyperum root bark or rhizome hot water extract 2.0

9. Spike or rhizome 30% 1,4-butylene glycol extract 2.0

10. Toki 30% 1,4-butylene glycol extract 2.0

11. Tomato fruit hot water extract 1.0

12.Hydroxypropyl chitosan solution 1.0

13. Hyaluronic acid solution 1.0

14.Dipotassium glycyrrhizinate 0.1

15. Antibacterial and antiseptic (photosensitive element 101) appropriate amount
16.pH adjusting agent
17. Perfume (flooded water) appropriate amount
18. Purified water

(Formulation example 20) Rinse mass%
1. Stearyl trimethyl ammonium chloride 3.0

2.Cetostearyl alcohol 3.0

3.Polyoxyethylene lanolin ether 3.0

4.Propylene glycol 5.0

5.1,2-Pentanediol 2.0

6. Salacia reticulata extract from Production Example 1 5.0
7. Pear leaf or stem 50% 2,3-butylene glycol extract 3.0

8. Yaba Santa fruit 50% 1,2-pentanediol extract 1.0

9. Tokakinka flower 50% 1,3-butylene glycol extract 1.0

10. Perfumed fruit 30% 1,2-butylene glycol extract 1.0

11. Yellow rhizome 50% 1,3-butylene glycol extract 1.0

12. Cherry fruit or flower 50% 1,3-butylene glycol extract 1.0

13. Soybean seed natto fermentation liquid 0.5

14.Hydroxyethyl chitosan solution 0.5

15.Hydrolyzed collagen solution derived from fish

16. Trehalose solution 0.5

17. Hydrolyzed silk solution 0.5

18. Antibacterial / preservative (benzalkonium chloride) appropriate amount
19. Perfume (salvia water) appropriate amount
20.Residue with 100 purified water

(Prescription Example 21) Rinse Mass%
1. Stearyltrimethylammonium chloride 2.0

2.Cetostearyl alcohol 2.0

3.Polyoxyethylene lanolin ether 3.0

4.Propylene glycol 5.0

5.Ethylene glycol 3.0

6. Salacia chinensis extract from Production Example 2 5.0
7. 50% 1,2-pentanediol extract from whole plant

8. Western bodhi tree flower or fruit 50% 1,4-butylene glycol extract 1.0

9. Olive leaf 50% 1,2-butylene glycol extract 1.0

10. Mugge fruit or flower 50% 1,3-butylene glycol extract 1.0

11. Sweet tea whole plant 50% glycerin extract 1.0

12.Bifidobacterium fermentation broth 1.0

13.Sodium alginate 1.0

14. Trehalose solution 1.0

15. Hydrolyzed keratin solution 1.0

16. Antibacterial / preservative (benzalkonium chloride) appropriate amount
17. Fragrance (Hamamelis water) appropriate amount
18.Residual water 100

(Formulation Example 22) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0

4.Triethanolamine 1.0

5. Salacia oblonga extract from Production Example 2 5.0
6. Apricot fruit 50% glycerin extract 1.0

7. Hop female flower ear 50% ethanol extract 1.0

8. Melissa whole plant 50% ethanol extract 1.0

9. Usbasaicin rhizome 30% ethanol extract 1.0

10 Birch sap 1.0

11.Carpronium chloride 0.3

12. Hinokitiol 0.5

13.Keratin degradation solution 0.5

14. Stearyl glycyrrhetinate 0.1

15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
16. Fragrance (Rosehip water)
17.Residue with 100 purified water

(Prescription Example 23) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0

4.Triethanolamine 1.0

5.1,2-hexanediol 1.0

6. Salacia reticulata extract from Production Example 2 2.0
7. Chamomile flower or fruit 50% 1,2-butylene glycol extract 1.0

8. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0

9. Ginseng root hot water extract 1.0

10. Apple fruit 30% ethanol extract 1.0

11. Sesamoline 0.3

12.azulen 1.0

13. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
14. Fragrance (orange water) appropriate amount
15. Residue with 100 purified water

(Prescription Example 24) Hair Liquid Mass%
1.Ethanol 40.0
2.Ethyl oleate 1.0

3.Polyoxyethylene (40) hydrogenated castor oil 2.0

4. Salacia reticulata extract from Production Example 2 3.0
5. Comfrey leaf or stem 50% ethanol extract 1.0

6. Peach fruit or leaf 50% ethanol extract 1.0

7. Soybean seed natto fermentation liquid 1.0

8. Hamelis leaf or stem hot water extract 1.0

9. Comfrey leaf or stem 50% ethanol extract 1.0

10. Lettuce leaf 50% ethanol extract 1.0

11.Carpronium chloride 0.3

12.Pantethine aqueous solution 0.3

13. Amino acids or their derivatives 3.0

(Lysine, alanine, pyrrolidone carboxylic acid, etc.)
14. Antibacterial / preservative (paraben, benzalkonium chloride) appropriate amount
15. Perfume (rose water) appropriate amount
16.Residue with 100 purified water

(Prescription example 25) Hair artnic mass%

1.Ethanol 40.0
2.Ethyl oleate 1.0

3.Polyoxyethylene (40) hydrogenated castor oil 2.0

4. Salacia reticulata extract from Production Example 2 3.0
5. Yachabushi fruit or seed 30% ethanol extract 1.0

6. Antibacterial and preservative (propyl paraoxybenzoate) 0.2

7. Residue with 100 purified water

(Prescription example 26) Hair artnic mass%
1. l-menthol 0.2
2.Ethanol 32.5
3.Polyoxyethylene hydrogenated castor oil 0.5

4.Propylene glycol 5.0

5.Diphenhydramine hydrochloride 0.3

6. Salacia chinensis extract of Production Example 2 2.0
7. Hypericum fruit or pericarp hot water extract 1.0

8. Western bodhi tree flower or leaf 50% propylene glycol extract 1.0

9. Lavender flower or flower ear hot water extract 1.0

10. Belode mallow rhizome or root bark 50% ethanol extract 1.0

11. Ogon rhizome or root bark 50% ethanol extract 1.0

12. Soybean seed hot water extract 1.0

13.Carboxymethylchitin solution 1.0

14 Chicken crown extract solution 0.2

15.Pantethine aqueous solution 0.2

16. Antibacterial / preservative (phenoxyethanol)
17. Perfume (lemon water) appropriate amount
18.Residual water 100

(Prescription Example 27) Hair growth / hair growth agent
1.Ethanol 60.0
2. Salacia oblonga extract from Production Example 2.0
3. Allergen 50% propylene glycol extract 2.0

4. Vitamin E derivative 0.5

5.Pepper tincture 0.5

6.Resorcin 0.5

7.Dipotassium glycyrrhizinate 0.5

8.Carboxymethylchitin solution 0.5

9. Collagen protein enzyme solution 1.0

10.Pig hematin solution 0.5

11. Porcine mucin solution 0.5

12. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5

13. Antibacterial and antiseptic (paraben) 0.1

14. Fragrance (rosemary water)
15. Residue with 100 purified water

(Prescription Example 28) Hair growth / hair growth agent
1.Ethanol 60.0
2. Salacia reticulata extract from Production Example 2 5.0
3. Aloe stem or mesophyll hot water extract 3.0

4. Whole plant 60% ethanol extract 3.0

5. Peony rhizome or root bark 60% ethanol extract 3.0

6. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0

7. Soybean seed natto fermentation liquid 1.0

8. 20% 2,3-butyleneglycol extract from the plant

9. Hot pepper fruit hot water extract 1.0

10. Cantalis tincture 0.5

11. Pantothenic acid derivative 0.2

12.β-Glycyrrhetinic acid 0.2

13.Resorcin 0.2

14.Hydroxyethyl chitosan solution 0.2

15.Elastin hydrolyzate 0.2

16.Keratin protein enzymatic solution 0.2

17. Preservative (paraben) 0.1

18. Perfume (bergamot water) appropriate amount
19.Residue with 100 purified water

(Prescription Example 29) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 5.0

4. Salacia reticulata extract from Production Example 2 5.0
5. Sorbitol 1.0

6. Peach leaf or stem 70% ethanol extract dry powder 1.0

7. Black tea leaf or stem 30% ethanol extract dry powder 1.0

8. Pigment (Gungjo Green) appropriate amount

(Formulation example 30) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 3.0

4. Hyaluronic acid powder 3.0

5. Salacia reticulata extract from Production Example 2 3.0
6. Papaya seed hot water extract dry powder 1.0

7. Yaba Santa whole plant hot water extract dry powder 1.0

8. Lily flower hot water extract dry powder 1.0

9. Orange peel 50% ethanol extract 1.0

10. Apple juice powder 1.0

11. Dye (Gunjou, chromium hydroxide) appropriate amount
12. Perfume (boiled water) appropriate amount

(Formulation example 31) Coating protective agent Gauze or liniment cloth is impregnated with a formulation solution in which appropriate amounts of Salacia reticulate, also known as Kothalahimbutu hot water extract, antibiotics, anti-inflammatory agents, etc. are mixed, Attach to the wound. Alternatively, a hot water extract of Salacia reticulate, also known as Kothalahimbutu, may be directly applied locally and covered with gauze or the like.

(Prescription Example 32) Toothpaste
1. Silicic anhydride 20.0
2.Sorbit liquid 50.0
3.Glycerin 10.0
4. Salacia reticulata extract from Production Example 2 3.0
5. Yaba Santa fruit or seed hot water extract 5.0

6. Sodium lauryl sulfate 2.0

7.Saccharin sodium 0.05

8.Carboxymethylcellulose sodium 1.5

9. Fragrance (cardamon water) appropriate amount

10.Coloring agent appropriate amount

11.Appropriate amount of purified water

(Prescription Example 33) Mouth freshener

1.Ethanol 20.0

2.Glycerin 15.0

3. Polyoxyethylene hydrogenated castor oil 1.0
4.Saccharin 0.2
5.Chlorohexidine 0.01
6. Salacia chinensis extract from Production Example 3.0
7. Hypericum leaf or stem hot water extract 1.0
8. Grapefruit fruit or leaf hot water extract 1.0
9.Green tea leaf or stem hot water extract dry powder 0.1
10. Pigment (Gunjo green) appropriate amount

11. Residue with 100 purified water

(Formulation Example 34) Tableware detergent mass%

1. Alkyl (C12) glucoside 20.0

2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0

3.Glycerin 2.0
4.Ethanol 5.0
5. Salacia oblonga extract from Production Example 1 3.0
6. Safflower whole plant hot water extract dry powder 1.5
7. Sandalwood whole plant 50% dipropylene glycol extract 0.5
8. Residue with 100 purified water

(Test 3) Use effect test The effect at the time of actually using the cosmetic composition of this invention was examined. The use test is paneled with 40 women (10 people per group) who are 31-44 years old who are suffering from dark and dark skin, and each day, twice a day in the morning and at night, after washing their face, the appropriate amount of the emulsion of Formulation Example 1 is applied to the face. This was done by applying for 3 months. In addition, what prepared the thing remove | excluding various plant extracts of this invention from the emulsion by the same method was used for the control | contrast. The evaluation method is based on the following criteria, and the results are as shown in Table 1. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.

“Blemish / Sobacus & Skin Color Improvement”
Effective: Blemish freckles and skin color are white and improved.
Slightly effective: Blemish freckles and skin color are white and slightly improved.
Invalid: No change before use.

(Test results)
As shown in Table 1, the cosmetic composition containing various plant extracts of Salacia reticulata, Salacia chinensis and Salacia oblonga according to the present invention significantly improves spots and freckles and whitens the skin color. Can be confirmed and can be used as a whitening agent.

(Test 4) Use effect test The effect at the time of actually using the cosmetic composition of this invention was examined. The use test was conducted by 40 healthy women 31 to 44 years old (10 people per group) as a panelist, and each day, twice in the morning and at night, after the face wash, the appropriate amount of the formula 1 emulsion was applied to the face for 3 months. It was done by doing. In addition, what prepared the thing remove | excluding various plant extracts of this invention from the emulsion by the same method was used for the control | contrast. The evaluation method is based on the following criteria, and the results are as shown in Table 2. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.

"Improve skin tension and gloss"
Effective: Improved skin tension and gloss.
Slightly effective: Slightly improved skin tension and gloss.
Invalid: No change before use.

(Test results)
As shown in Table 2, it was confirmed that the cosmetic composition containing various plant extracts of Salacia reticulata, Salacia chinensis and Salacia oblonga according to the present invention significantly improved skin tension and gloss.

It is a figure which shows the melanin production suppression rate of the various plant extracts of Salacia reticulata of this invention, Salacia chinensis, and Salacia oblonga (Example 2).

Claims (2)

A melanin production inhibitor comprising one or more plant extracts selected from Salacia reticulata, Salacia chinensis, and Salacia oblonga. A cosmetic composition comprising the melanin inhibitor of claim 1 containing at least one plant extract selected from Salacia reticulata, Salacia chinensis and Salacia oblonga.

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