JP4250640B2 - Acne cosmetic composition - Google Patents

Description

  The present invention relates to an application to an acne cosmetic composition containing a lipase activity inhibitor containing a cobotanum extract.

  Acne vulgaris (acne), which can be particularly common from adolescence to adolescence due to worsening environmental conditions, changes in lifestyle, and increased stress associated with social life, has recently been observed regardless of gender or age , Has become one of the major skin problems.

  There are two main stages in the development of acne vulgaris. At first, the plugs (keratinized and sebum mass) clog the sebaceous hair follicles, and comedo. Occurs. At this time, the comed is non-inflammatory, but then changes to an inflammatory rash that is difficult to treat, such as papules, pustules, and cysts.

  The cause of this occurrence is deeply related to three factors: endocrine factor (enhancement of sebaceous gland function), bacterial factor (propionibacterium acnes growth), and keratinization factor (keratoinjury of hair funnel). It is said that inhibition of lipase activity is greatly involved in one factor (bacterial factor).

  That is, as the early stage of acne generation, when sebum secretion is activated / increased, Propionibacterium acnes produces enzymes such as hyaluronidase and protease in addition to lipase. Lipase also hydrolyzes triglycerides in sebum to produce free fatty acids. This free fatty acid stimulates the hair follicle wall, promotes keratinization, and promotes the formation of comeds. Furthermore, hyaluronidase and protease stimulate and destroy the follicle wall of comed (face), forming inflammatory acne such as papules and pustules. However, by inhibiting the activity of lipase, the production of free fatty acids, the inhibition of keratinization damage, and the formation of comedo (surface) are suppressed, and sebum secretion is rapidly secreted into the epidermis. Become.

In recent years, the production of active oxygen in the living body and various effects (diseases) caused thereby have been reported. In general, this active oxygen is also called Activated oxygens, and is roughly divided into four types: O ²⁻ , H ₂ O ₂ , .OH, and chemiluminescence. It is captured as an important substance involved in defense. For example, when an external enemy such as a bacterium, virus, or foreign substance (an antigen) enters the living body, phagocytic cells, neutrophils, monocytes, and macrophages are first phagocytosed. In order to start the action and then to lyse the phagocytic foreign bodies in the phagocytic vesicles, active oxygen is produced, and this produced active oxygen, on the other hand, is equivalent to the lysis of the sputum food It plays a role of directly bactericidal action against external enemies such as bacteria and foreign substances, and defending from external enemies. In other words, it has the function of eliminating antigenic substances before the immune function is activated.

  However, if this active oxygen for self-protection is excessively produced and secreted, even normal cells are lysed and stimulated, resulting in various disordered reactions. Recently, many diseases and illnesses induced by active oxygen have been reported. For example, fats and oils such as cholesterol in the blood are oxidized by active oxygen, and blood vessels are damaged by arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.) It is said to cause blood flow disorder due to thrombus and the like, and ischemia in blood vessels due to rapid temporary atrophy during the brain trauma, resulting in an oxygen deficient state. Therefore, in this state, the xanthine dehydrogenase in the blood vessel is changed to xanthine oxidase, and a large amount of active oxygen is generated in the blood in the blood vessel, causing damage to the blood vessel wall and causing fatal damage. .

  Furthermore, looking at the relationship between the skin and active oxygen, for example, because the skin is an organ that directly contacts the outside world, the active oxygen continues to be excessive in the skin due to ultraviolet rays, radiation, etc. in a state that is susceptible to environmental factors. Then, it reacts with the unsaturated fatty acid of the biological membrane phospholipid and lipid peroxide is produced. The generated lipid peroxide causes arteriosclerosis, carcinogenesis, aging, membrane destruction, protein denaturation and the like, and also causes skin inflammation, edema, wrinkles and the like. Furthermore, as a disease caused by excess of active oxygen, from a cosmetic viewpoint, for example, herpes dermatitis, X-ray dermatitis, burns, trauma, solar dermatitis, contact dermatitis, eczema, atopic dermatitis, etc. It is said to reduce skin tension and gloss.

  However, the above-described lipase activity-suppressing component or active oxygen-eliminating substance is poor in stability and solubility in the formulation system, has a bad smell due to starch or decomposition, coloring, and is not sufficiently effective at the biological level, Furthermore, there were problems in terms of safety such as rash on the skin, which was not satisfactory.

  In addition, as external preparations effective for acne treatment, keratolytic agents (resorcin, salicylic acid, lactic acid, etc.), anti-seborrheic agents (pyridoxine or derivatives thereof, sulfur, vitamin B6, etc.), antibacterial agents, anti-inflammatory agents, etc. Although there are no known substances having a lipase activity-inhibiting action, the present situation is that.

  In view of these circumstances, the present inventors set various themes useful as lipase activity inhibitors as the theme of development, and as a result, confirmed that coconut knead extract has a lipase activity inhibitory action, and thus, lipase activity. The present invention has been completed by providing a safe cosmetic composition for acne that can be used as an inhibitor to improve acne.

  The cosmetic composition for acne containing the lipase activity inhibitor containing the cobotanum extract of the present invention can suppress lipase activity and improve acne. In addition, it is safe for humans or animals to be used internally or externally, and can be applied to all forms of preparations (pharmaceuticals, quasi drugs, cosmetics).

As used herein, the term “kobotanru” (also known as clematis, clematis) refers to the plant of the family Rannclaceae and genus Clematis: kobotanu “Clematis vitalba L. (= C.brevicaudata DC.)” Flowers, spikes, pericarps, fruits, stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root barks, roots, seeds or whole plants are used .

  The extract of kobotanru used in the present invention refers to various parts of plants (flowers, flower spikes, fruit skin, fruits, stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root barks, roots, seeds or whole plants). Squeezed after being crushed. Alternatively, it is extracted as it is or after pulverization with a solvent.

  It should be noted that the extraction solvent for the cobotol extract may be selected in consideration of the intended purpose and type of the product to be provided, or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol , Lower alcohols such as butanol and isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or water-containing polyhydric alcohols, and various organic solvents such as acetone and ethyl acetate. It is desirable to use one or a mixture of two or more. However, when it is not preferable to contain an organic solvent depending on the purpose of use, only water may be used, or ethanol that is easy to remove after extraction may be used alone or in any mixture with water. , Exploited and extracted. Furthermore, it can be used in a state where each solvent extract is combined.

  In addition to hydrolytic extraction of cobotanum by enzymatic decomposition, those obtained by hydrolysis with acid or alkali can also be used.

  The production method is not particularly limited, but is usually within the range of the boiling point of the solvent at normal temperature and normal pressure. After extraction, filtration or ion exchange resin is used for adsorption, decolorization, and purification. A solution, paste, gel, or powder may be used. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decoloration may be added as long as the effect is not affected. An activated carbon column or the like may be used, and usual means generally applied depending on the extracted substance may be arbitrarily selected. In addition, an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, phenoxyethanol, or an arbitrary mixture thereof can be added to the extracted liquid after extraction. Although the obtained extract can be used as it is, it can be concentrated and dried to be used as a paste or powder.

  The coconut knead extract of the present invention can be contained in the lipase activity inhibitor and the acne cosmetic composition, and the content thereof is not particularly specified, but the types of the lipase activity inhibitor and the acne cosmetic composition, It varies slightly depending on the quality and expected action, and is usually 0.0001% by mass or more (hereinafter expressed as%), preferably 0.01 to 50.0% in terms of solid content in the total amount of the preparation. . Moreover, in the case of a bath agent, the prescription may be taken into consideration so that it is poured into 200 to 300 L of bath water to obtain a similar concentration.

  The dosage form / form of the acne cosmetic composition of the present invention is arbitrary, and it is used in the form of capsules, powders, granules, solids, liquids, gels, bubbles, emulsions, creams, ointments, sheets, etc. be able to.

  The fields of use can be used in, for example, various types of internal and external preparations (including preparations used for animals), specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Appropriate forms for use in liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (eg cosmetics) Basic cosmetics such as water, emulsion, cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, poultice, plaster, tape, sheet, patch, aerosol Agents), 4) bathing agents used in hot water, 5) other anti-smell and deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissue and the like.

  Incidentally, the acne cosmetic composition of the present invention is optionally selected and used in combination with the components and additives exemplified below within the range that does not impair the effects of the present invention, in addition to the above essential components. Although it can manufacture and the content in a formulation is not prescribed | regulated in particular, 0.0001 to 50% is preferable normally.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber oil, safflower oil , Shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, palm Oil, beef tallow, pork tallow, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil, etc.).

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.

(3) Mineral oils Liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid Synthetic fatty acids such as natural fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) Alcohols: natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol .

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, Diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) gum, sugar or water-soluble polymer compound gum arabic, benzoin rubber, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or ester thereof, Trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular chitin Or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose Polycarboxylate such as carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide Alkylene oxide or its crosslinked polymer, carboxyvinyl polymer, polyethyleneimine and the like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric Surfactant: Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant ( Ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants ( Natural surfactants, protein hydrolyzate derivatives, polymer surfactants, surfactants containing titanium and silicon, fluorocarbons System surfactant), and the like.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), Riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: Ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or derivatives thereof, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), me Dione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine , Arginine, ornithine, histidine and the like, and their amino acid derivatives such as sulfate, phosphate, nitrate, citrate or pyrrolidone carboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, grinding, milling, washing, hydrolysis, fermentation, purification) , Compression, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., arbitrarily selected and combined), arbitrarily selected from various materials You can use it.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol 1 type selected from various organic solvents such as lower alcohols such as isobutanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, acetone and ethyl acetate Alternatively, it is desirable to use a mixture of two or more. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.

  In addition, when using additives derived from plant or animal-based ingredients for systemic or topical external preparations and cosmetics, it protects skin and hair, moisturizes, improves touch and texture, imparts flexibility, and stimulates Relaxation, stress relief by fragrance, cell activation (cell aging prevention), suppression of inflammation, improvement of skin and hair quality, prevention of rough skin and its improvement, hair growth, hair growth, hair loss prevention, imparting gloss, cleansing effect, In addition to cosmetic effects such as fatigue relief, blood flow promotion, and warm bath effects, effects such as flavoring, deodorization, thickening, antiseptic, and buffering can also be expected.

Specific plants (herbal medicines) as raw materials include, for example, almonds (toen), ai (indigo leaves), aokazura (Keifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Ao Tung), Aotsu Samurai (wooden candy) , Aotenma, acacia, red ginseng, red spruce `` fruit '', red clover, red grapes, red ginseng (logwood), red wrinkles (red buds), red crested or red crested or reddish (root), red crested or reddish (ground yellow), Agi (Aki), Aki larch, Akinire (crusted skin), Aguay Guassou, Aguahe (Omiten coconut palm), Akebi (Kitsu), Asa (Asakojin), Maruba morning glory or morning glory (Chicken), Hydrangea (hydrangea), Ashitaba (Tomorrow), Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asenyaku), Athira (Shokuyokanna), Anise, Abiyu, A Biurana, oilseed rape, Abemaki `` fruit '', avocado, ama, achacha (Amacha), Achacharu, Amadokoro (Jade bamboo), Amana (a light-hearted), amaranth (Hyuyu, Hagatetou, Himogeito, Senninkoku, Sugimorigateto, Hosoaogeito, Hasoagoito Aozulan, Amaranthus hypochondriacus), Amigasayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Arcana (Alcanna), Algarrobo (Cabe), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe (蘆薈), Aloe vera, angelica, apricot or honanzu (Anzujin), Ansokkou (benzoic incense), yellow support, igakozolina (geo-biliary head), licorice or gecko licorice (indian oyster), rush (light heart grass), itadori (tiger cane root), yew (one Place), Strawberry, fig (no flower `` fruit, leaf ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one medicinal herb), ginkgo (Ginkgo `` seed, leaves ''), Japanese yellow peas (distant), carob, Japanese beetle ( Taillexi), Inubiyu (Honagainubiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibuki-so-sou, Nettle, Ylang-ylang, Iwa-tobacco (Iwabuchi), Iwahiba or Iwamatsu (rolling mushroom), kidney beans, oolong tea, fennel (mustard) , Wheat (Chibusanoki), Ukiyara (Sanryo), Uguisukagura `` Fruit '', Himewikyo, Turmeric (Urban), Duckweed, Usubasaishin or Keirinsaishin or Oshusaishin (spicy), Usvenia Oy, Usbeni Hollyhock, phalaenopsis, weevil (summer hay), udo or shishiudo (gung, alone, tangy), unyadegato (unkari) A, Cat's Claw), Uba Tea, Ume (Plum Plum `` Seeds, Flesh ''), Vulgaris, Uwaurushi (Kusako-kemomo), Satsumikan (Chen), Unboku, Estragon, Ezoukogi (Tsuga Goka), Ezo-suzuran, Echinashi (Hosobamurasaki Barengiku) , Enishida, Enokitake (榎 茸), Ebisugusa or Cassia Tora (Keiko), El Campre, Elderberry “fruit”, Elemi, Elingi or Pre-Lotus Elinji, Enju (Safflower, Camellia rice), Pea, Ogi or Kibanaogi (Yellow Twilight), Naruko Yuri or Kagura-mabanaru Koyuri (Yellow), Ohisasa Yuki or Sasano Yuki, Ouren (Yo Ren), Ogata Houken, Okarasuri (Karokon), Oguruma (Civil Works Incense), Otsu Samurai (Prevention), Psyllium , Car forage), toucan thistle (Zhengzhou leakage, bald eagle), toucan Mi (coconut palm), Toucan cactus, Ovana okera or okera (white moth), Osara squirrel (Banaba), Ooyabaya shabushi "fruit", Oohashigusa (cereal sperm), Omia catechu, Oomihasa or Hawthorn (Mountain vegetation), Omiyashi, Omiji Barley), Oka, Okazeri (snake bed), Okra `` fruit '', Oguruma (overturn), Oguri higotai (Zhengzhou leakage, indigo head), Panax ginseng or Tochibaninjin (Ginseng), Hypericum pertussis or Pterotus pertussis or Hypericum perforatum (Brother cut grass), Odorikosou (continuous), Onamomi (Circle ear), Onigomi, Onikoro or Tokoro or Nagadokoro (Hikai), Oninoyara (Tempa), Onyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Halibut楡), Ominae (losing sauce), Yuuko, Dutch mustard (watercress), Ora Dazelli, Dutch beech, Dutch bees, olives `` fruit, seeds, leaves '', oregano, orange `` fruits, peels '', silkworm (ripe yellow), cacao `` fruits, peels, seeds '', oysters (bamboo `` leaves ''), Kagi-Kazura (Katsufuji), Kakidooshi or Kantorisou (Lotus), Kakiran, Gaku Hydrangea, Cassia, Casinoki (fruit berries), Gadju (Kashiwa), Kashiwa (Kashiwagi, Kashiwa), Cascarilla, Cascala Sagrada, gypsophila, gypsophila, cynomolgus (Kinshato), kaniwa, carnation, valerian (valerian), hippopotamus, birch or fern birch (white birch), gerbera, pumpkin, kapokoki `` seed '', kahoku salamander (蜀椒), gama Yellow), chamomile or roman chamomile, chamomile (weed), cam cam (camo duck), collar, chrysanthemum, calla or cinnamon , Oat biscak (half summer), oats, guarana `` seed '', carahoo (kokubaku), karaya, galyu, karin (garden), garcinia, kawamidori, kawara-saiko (reeled rape, white millet), kawajisha, kawaratake, kawaranadeshiko ( (Stone bamboo) or Ezokawaranadeshiko (buckwheat noodles, buckwheat), Chinese carrot (blue potatoes), Chinese mugwort (bamboo chin mackerel), kansui (kansui), licorice (licorice), kantarasa, candelilla, kanto, canna, kanran, raspberry (ezo strawberry) , Dutch Strawberry, Shrimp Strawberry, Nawashiro Strawberry, Momiji Strawberry, European Raspberry Strawberry), Kiwi `` Fruits, Leaves '', Kikarasuuri (Gurone), Chrysanthemum (Kikyo, Kikyo-root), Chrysanthemum (Chrysanthemum, Chrysanthemum, Datura), Kikutanigiku, Kisage (Salmon), Gigigishi (sheep hooves), pheasant (salmon), Kizuta, Kidachi aloe, Kidachi mint , Quina, linden (shinkona, red linden), quinoa (quinoa), yellowfin (yellow tuna), bean, gymnema sylvester, kimenkaku, cabbage, cabbage `` unripe fruit '', caraway, cucumber, gyory (Nishikawa willow, tail willow), Kiraja saponaria, Kiraya, Kiransou (Kinza small grass), Kumquat `` fruit '', Kinkiju, Ginseikai, Kimbusen, Kinma, Kinkihiki (Sentsukusa), Kinlan, Ginlan, Ginryohen, Guapeba Vermela, Guava `` Fruit '', Guayule, Quercus・ Infectria (garlic pods), kukui nuts, kugenumaran, wolfberry (bamboo shoots, coconut palm leaves, cocoon leaves, ground bone skin), cedar casserole (Tenmon winter), kudu (kudzu), camphor tree, gooseberry `` fruit '', ginseng (yellow flower candy) ), Kutiti River, Gardenia (Yamako), Kunigi (Kusou), Kupu , Kubeba, Kumazasa, Kuma-tsutsura (horse whip grass), Clara (bitter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curcumigo latifolia `` fruit '', grapefruit `` fruit and leaf '', buckthorn, kuroganemochi ( Rescue), Kamehiba Kokoshi or Kurobana Hikikoshi or Hikiokoshi (prolongation grass), Clove (clove, clove), Gumbai Tuna (Sekimei, Sekimeishi), Keigai (Kashiwa, Aoiho), Celosia (chicken flower, chicken crown), Gekkavidin, Gecko (Laurel Tree), Kenashi Sartoribaira (Dogo, Mountain Return), Gentiana, Gennoshouko (Old Grass), Kemponashi (Kigushi), Kokisekoku, Kishimizukan (Koji, Tachibana, Obenimikan, Fukurimikan, Sagamikouji, Ponkan, Santara Skin) ), Koshinbara (monthly flower), Koiusui mint, Kozo `` Fruit '', kocha (tea), kohone (river bone), koh hong (Tsubakimoto, Karamotomoto), Kouriang, Kouryokyo (Koryo), cilantro `` fruit '', Koouren (Huo Ren), Koganebana (Yellow Gon), cowberry (Etsu) Tachibana), Coco `` fruit '', Goshuyu (Kurei), Gosho strawberry (Golden bonsai), Pepper (Pepper), Cosmos, Copaiba balsam, Coffee `` Seeds, leaves '', Kobushi or magnolia (hot pepper), Burdock (Beef bowl, Gyudon) ), Sesame (sesame seeds), sesame seeds (genus ginseng), trash (goji), sakanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran `` red rice cake, birch '', rice oil, cola acminata `` seed '', cola・ Bella `` seed '', colony llah, fenugreek `` fruit '', colombo, konzlango, kombu, konjac, confrey (birch grass), sisal (sisal asa), saihailan, sakaneran (d Zosakaneran), Sakura (Oshima cherry, Yamazakura, Oyamazakura, Edhigashi, Bean cherry, Miyazaki cherry, Yoshino cherry, Takane cherry, Kasami cherry, Kohigan, Sato cherry, Kanzakura `` Leaf, flowers, fruit, bark (cherry bark) '', cherry cherry, pomegranate , Sasabagin orchid, Sasanka, Sajimodaka (Sawabuchi), Sweet potato, Sugar cane, Sugar beet, Sunflower jujube (Acetic acid jelly), Saffron (Bansai flower, West safflower), Sapodilla, Sapotea mariyo, Zabon `` Fruit '', Sabonso, Salmon berry `` Fruit '' Shouma (Sesame), Salamander (sand indigo sashimi), Salvia (sage), Sagaki (mountain curd), Sawagurumi (wild walnuts), Sakaku cactus, Sangre de grad (croton), Sangikuyosou, Sanshi carrot (three Ginseng), Sanshuyu (Sanjo), Sun Leopard (Yamamuro), Sandskon (Yamazune), Shia (Kalite), Cyanoki `` Fruit '', Shiitake mushroom (Shitake), Zion (purple strawberry), Deer bean, Diquitaris, Sikunshi (Amiko), Perilla (Shiyo leaves, Shisoko), Rosewood, Shinanoki, Shinohonoki, Sinarenkyo (ream), Shimeji (Hinshimeji, Shakashimeji, Hatake-Shimeji, Oshiroi-Shimeji, Buna-shimeji, Honjimeshi, Shirotamogitake), Shimokuren (Shigeki), Shimo-gakuso Glaze), shajin (shasan), jasmine (matsurika), janohi (barley winter), jujube cowpea, shukukonkamisou, shukushamitsu (sand jelly, shredded sand), juzudama, shuro "fruit", shunglan, zebra Ginger (Ginger), Zhouzan Hydrangea (Tsuneyama), Shobu (Sardine, Sone), Sho `` Fruits '', Shirakashi `` Seeds '', Silane (Bikkyu), White Rooster butterfly `` Seeds '', White clover (Clover), White clover (chicken bone grass), Shirobanairis (Nioiris), Shirobanatsuta `` Flowers '', Shirobanarupin, Shirominanten (south sky) Fruit), cinchona sill bra, ginkgo biloba (Mizuka, Mizuka flower, Shencho flower), cinnamon, cinnamom cassia (cinnamon), watermelon (Saijo), honeysuckle (gold-silver flower, Shintofu), sorrel (Acami), swimberry "fruit" , Star Apple, Stevia, Strawberry "fruit", Psycho (Xucho), Sugina (question), Surihiyu (horse tooth, horse tooth soap), Plum "fruit", Sulgaran (Oran), Scots pine cone , Larch, ivy, walnut, hawthorn, cypress, dandelion, Horse chestnut (marronie), pear `` fruit '', psyllium prunus, elder, prunus (juniper, pine), yarrow (milfoil), rose, pearl butterfly, mistletoe, mint mint Yamaha mint, horseradish, budgerigar (pepper), budgerigar (blossom) Hiroha Senega, Senega, Seri, Celery, Senkyu (river cucumber), Senshinren (Centennial ream), Sendan, Sennin cactus, Senna `` Fruit, Leaf '', Senburi (Takumi), Senboku, Soka (grass), Elephant Chu, Soshin-waby, buckwheat `` seed '', Somer potato, broad bean, Daio (daihuang), Japanese radish, soybean, Daidai (orange peel, fruit), Takasagori higotai (Southeast indigo sashimi), Takasaburo (Chinese lotus), Takatodai (large)戟), Takara-bi (pig spine), dark sweet cherry `` fruit '', hollyhock, prickly-spotted thyme (thyme, perilla), tachidokoro (hikai), tachiyanagi, tamarind `` seed '', onion, ramshiba (powder), taranoki `` fruit, leaf ``, Root bark '', tarayou (Oba winter blue, Ichiha tea, bitter tea, bitter tea), dahlia (tenjiku button), tarwi, tanukirimame, tanshichiwa, tanjin (dansang), dandelion (Sanko) or Shirobana dandelion or mouko dandelion, Danmar, cherry `` fruit '', chigaya `` fruit, root, bud '', chixetsu carrot (bamboo ginseng), chicory, chankapiedra (ki Nigirikansu, Tulip, Chokono Stay, Datura Thistle (Artichoke), Dendrobium (Dahi), Datura (Camellia), Datura Mugwort (Bamboo Leaves), Choreimaitake (Camellia), Chorogi, Tsukimiso, Tsukushikananeran, Tsukuritake (Mushrooms), camellia, camellia, camellia, clover (lacquered cocoon grass), camellia (duck cocoon grass), tsurumazuki (red azuki beans), tsurutsuchiakebi, tsurudukudami (what neck rice cake), tsuruna (apricot apricot), tsuruminjin (four leaf ginseng), tsurumame , Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tengusa, Tencha (shade tea), Tendai Yaku (glaze), Toga (winter lion), Toka Kazura, Capsicum (Ganban), Touki (Toyaki), Tokinsenka (Marie) Gold), horned bee, touna bena (river cut), corn or corn hair (south Eyelashes), hornworms (Sadako), Torindo or Kyakusen Lindou (Dragon gall), Tokusa (wood band), Dokudami (10 medicines), Tokushi (Togashi), Toshishi or Mamedaoshi or Nekazura, Tochu (bark, bark, leaves , Root ''), ash (crust), tomato, tragacanth, triacanthos `` seed '', Turkish almonds, tormentilla, dronoki, troro mushroom, tonka bean, nigerian berry `` fruit '', Chinese yam or yam (wild boar), nagii kada (butcher bloom) , Naginata cucumber, Nazuna, Rapeseed, Natsume or Hatehaki (sword beans), Natsumikan, Jujube (Otsuchi), Naniwaibara (Golden cherry), Navena (continuous), Nameko, Nankin bean (peanut), Nanten (Southern fruit), Nambang Karamushi (Sesame), Niosumire, Nigaki (Nakiki), Nigamomogi (Anniversary), Nikuzuku, Kei or Nikkei or Seiro Nnikkei or Yabunikei (Cinnamon) or Keishi (Keishi branch), Flying tiger plover, leek (lion), elderberry (bone, `` fruit, flower, stem, leaf ''), garlic (large persimmon), Nurde (penta), leek, nemonoki or Nebu or Nebi or Nemuroki or Zigokubana (community), Noazami (Otsuka), Neubara (Natural), Nozenkazura (Lingen Flower), Nogateto, Yarrow, Nodake (Maehu), Novara, Peach, Pineapple `` Fruit '', Hibiscus (Busouge, (Fuline Bussouge, Roselle), Hailindo, Hauchiwa, Pau Dorse, Hakama Labosi (Bone Fracture), Hakukayumatou, Nakusanchidori, Hakusen (Shirakagi Skin), Hakulberry `` Fruits '', Jacobe (Fresh), Hazel (Egg) (Roth root), basil, lotus (lotus, lotus meat, lotus), parsley (holland jellies), humpweed, batata, wasp or mada (Bamboo candy), patchouli, mint (thin load, light load leaf), yellow peas, yellow barley (yokuinin), hanasuge (knowing mother), banana, hana hakka, hanabishi (shitsurishi, shitsutsuri), vanilla bins, papaya, hakakugusa (bamboo grass), Pahalobobo, hub `` whole grass, stem, leaf '', paprika, Hamakakiran, clam or honey beetle (vine lion), hamasuge (kotsuko), hamabishi (shitsu lion), hamanas (maikai flower), hamabofu (hama wind), hamamelis , Palm, rose (bara), balata, balata rubber tree, agaric (agaric, white-faced agaric, edulis), haran, pauliurus, parietalia, harukanran, balsamina (crustacea, bitter gourd), haruni , 楡 葉), Barbasco, Harlindow, Handaikai (胖大海), Pannoki, Hio Gibbon (shallow radish), lizard carrot (participant), pecan nuts, ganbanana (stone wall, vine pearl shahua), Higuruma dahlia, higotai, hishi (rhizomi), pistachio, beet, hitsumiwa (stone wall), human winged fern, daisies (Daisy), Hinata Taikozuchi (cow knee), chickweed, cypress, hiba, castor, sunflower, bell pepper, Himezu (Tengu), Himamatsu (Kaori), Himematsutake (Kawariharatake, Hiromatsutake), Himemuyoran, Pimenta `` fruit '', Beakshi, beakkyu, jade "fruit", chickpea, lentil, bellowed oyster, hirohaokinagusa (bald eagle), loquat "fruit, leaf, stem", betel nut (large clothes skin, coconut), puer tea (common tea), sweet pod (Southern rattan), Japanese cypress, Japanese cypress poppo (Japanese winter flowers, Japanese winter leaf), Fujibakama (Orchid), Japanese bean (Japanese peas), Japanese white-bellied cherry (Chrysanthemum cherry, Japanese cypress) Grapes "fruit, pericarp, seeds, leaves", beech, Fuyumushinatsutake (Cycium Cordyceps), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, black currant "fruit", blackberry, buranyen, plum "fruit"'', Frucereria, Blueberry (Prunus aegypti), Prunes, Floral Blanca, Blond Psyllium, Bundow (Mung Beans), Hazelnut, Loofah, Hetsukaran, Safflower (Safflower), Heneken, Belladonna, Berry "Fruits", Percea, Pervianburg, Pereschia・ Grandifolia, Astragalus or Ikusa (Scenic), Boysenberry `` fruit '', Broom or Niwaxa or Nendo or Hahagaki Kokia (Gerva), Hausairan, Butterflies (Daffodil, Acute kid, Pelvic grass), Pouteria sapota , Poute Rear rumuma, spinach, bow-fu (windproof), spinach, physalis (Torone), honoki (Japanese folk pak, pak), bokeh (wooden moss), hosoba-a-baku-giku (bitter-yoku), hosoba-oguruma, hoso-banaokera (蒼朮), (Keitenzochi), Hosobabarengiku, Bodaiju (bamboo tree), button (peony `` flowers, leaves, stems, bark ''), button pi (peony skin), hop, jojoba, borage (Lurichisha), Bordeaux, howtle berry `` `` Fruit '', Hononiku (meat jutsu, large art), Honsecek (iron skin stone shark, sparrow mountain stone shark), myzurutennansho (Tennan star), Maitake (maiko), maou (mao), maca, macadamia nut, margaret (mok) (Shungiku), Makri (Marine Grass), Magwa (Mulberry White Bark `` Bark, Leaf ''), Magnolia Splengeri, Masalan Saba, Masalan Suba de Searer, Masheira de Boi, Sure (Tamanowenhalen, Kyukonkinrenka), Matatabi (wood tengu), matsukasa, pine `` leaves, bark, root '', matta auryo, matsuhodo (mushroom), matico (cordon sillo), maryoram (hanakakka), malvano jardin (Bitter), Mulberry `` Fruit '', Quince, Malene (Biloud Mouse Squid), Mango, Mangosteen, Manzanya (Andesuka Mitsuru), Manshugurumi, Mandarin `` Fruit '', Mannentake (Ganoderma biloba), Pheasant (fruit berry `` Fruit '') , Mishimasaiko (Saihu), Mizusobako or Mizuasagao (Dongweed), Mizokakushi (Half-sided lotus), Misohagi (Chinese green), Japanese willow or Japanese willow (Henpo), Mitsugasiwa, Mitsuba, Midorisapote, Mirimaza, Mimosa, Myoga, Miracle fruit “fruit”, myrrh, mirobalan, wheat straw, mugweed, mugno , Mukuroji (life-prolonging skin), Munya, Murasaki (purple), Murasakikikibu or Omurasakikibu (purple pearl), Murasaki corn, Murasaki Kinafuji (Kunming chicken blood wisteria), Megakansa Opuntika, Meadow grass (beneficial herb), Mebougi, Japanese evening primrose (Evening primrose) ), Melaleuca, Melissa, Melilot, Melon `` fruit '', Moukomugi, Mosouchiku, Mokkirin, Mogi (Pepper), Mochinoki, Mokko (woody incense), Momijidaio, Peach (peach `` leaves, seeds, flowers, fruit '') , Sprout, morello cherry `` fruit '', morohaya (burlap), yakawa murasimo, yakchi (masutachi), cornflower (cornflower), cornflower mint, yacon, yachabushi (carrot) or cyprinus shabushi or oyabayashabushi `` fruit, pericarp, fruit ear ”, Yachiyanagi, Yatsude (octagonal gold plate), Mistletoe (willow infestation), Willow ( `` Way willow, twill willow, weeping willow, red willow, cat willow, Incolyana nagi, kinu willow, cory nagi, unryu willow, miyagi willow, palm, yama willow, beetle, beetle spruce, foxglove, bee , Yabu tobacco (crane, Tenmeisei), Japanese pokeweed (commercial land), Japanese alder (Yamamuro), Japanese yam, Japanese mugwort, Eucalyptus, Yukinoshita (tiger ear grass), Yucca or flavifolia, Yuzu "fruit", lily , Wormweed, Artemisia (Leaf), Ligan (Raimaru), Lime `` Fruit '', Rye, Lacanca `` Fruit '', Raspberry `` Leaf, Fruit '', Latania (Clamelia), Lackey or Shallot (Lady), Lavender, Longan ), Agave (Aonus agave, Rinus agave), Ryokucha (green tea), apples `` fruit, seeds, leaves, roots '', gentian, lubas or suabisimus (cool), Ruritama thistle (Vulgaria chintai, Xinjiang indigo head), litchi (toothpick, toothpick), Lettuce (Chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or Chinese forsythia (ream), forsythia, wintersweet, wax palm, locon (reed, root), logan berry `` Fruit ”, rosemary (mannenrou), rosehip (novara), wasabi, cotton wisteria (hermitian flower), and bitumen (ground).

  As seaweeds, seaweed [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (usba aonori, Sugiaonori, Hiraaoori, Boaonori, Hosoeda Aonori), seaweed [Brown algae] (Macombu, Resilibu, Hosocome, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis Integrifolia, Neocitus Ruetkeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa Umiuchiwa, Akaba Umiuchiwa, Konami Uchiwa, Okinawa Uchiwa, Usuki Uchiwa, Etsumi Uchiwa], seaweed [Red algae: Hijirimen, Maca (Tengusa), Hiraksa, Syria, Oaxa Caterpillar, Yatabegusa, Yuukiri, Shimatengusa, Tosakanori, Togekirinsai, Amakusakirinsai, Giraffe, Juniper ginkgo rhinoceros, Tsunomata, Totsuka (Yahazutsu notamata), Ezotsunotamata, Togetu no Takita , Yareus banori, Kagius banori, Susius banori, Haius banori, Akamo jinori] and the like.

  In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kuwanomimo: Kuwanomimo, Volbox: Ohigegawa, Volbox, Palmera, Yotsumeo, Aomido: Chrysanthemum, Aoumidro, Tirguimidro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa Magama genus: Magamata, Iwagata: Fusaikawa, Surichogata, Heraiwata, Kurokita, Hanemo, Genus: Mill, Chromel, Sakibutimil, Nagamil, Hira Lemon, Casanori genus: Casanori, Jusmo genus: Jujusmo, Tamajusmo, Mizojuzumo, Mika ヅ kimo, Korekaete, Tsutsumimo genus: Kyukougusa, Hitogususa genus: Humanegusa, Hirohatohigususa, Umushihimoe, Sakikimoe Sumiremo: Sumiremo, Hoshimamidro, Fushinashimidoro etc.).

  Cyanobacteria (Suizenjinori: Suizinori, Aoko, Nenju: Kawatake, Ishijelly, Hassai, Yuremo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Iaciasio), etc.

  Brown alga Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa: Ezoyahaz, Yahazugusa, Uraboshiyahaz, Jigamusa: Jigmygusa, Umichiwagusa, Umamisakugakua, Hakusou : Navarimo, Chasomen genus: Motsuki Chasomen, Matsumo genus: Matsumo, Nagamatsumo genus: Nagamatsumo, Okinawa mozuku: Okinawa mozuku, fake Tomozuku: Niseft Mozuku, Futomozuku: Futomozuku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozuku, Mozuku: Mozuku, Ishige: Ishige, Iroro, Ichimosa: Ichimegasa Umibosu, Urushigusu: Urushigusa, Keurushigusa, Tobaccogusa, Composita: Composita, Haberodomo: Haberodoki, Havanori: Habanori, Habanori: Habanori, Commonbukuro, Ezobukuro, Ezobukuro Chishima fukuronori genus: Chishima fukuronori, Kagomenori genus: Kagomenori, Muraridori genus: Murachidori, shark genus: shark zusa, genus genus: lobster, genus genus: yokojimamanori, Ganoderma genus: cynomolgus, fennel spider: fennel spider, vine genus: turmo, turtle genus: sea turtle, scorpion genus: sujime, misji kumbu genus: misji kumbu, atsuba misji kumbu, kumbu genus: tsutsugara kumbu, oyster kumbu, onikombu, gakonbubu Barracuda, Trollocombu: Trollocombu, Antokume: Antokume, Kajime: Kajime, Tsuruarame, Kurome, Kikuishikombu: Kikuishicombu, Nejikcombu: Nejicombu, Kuroshiome: Kuroshiome, Nekoshikonbu, Aramei Genus: Ainuwakame, Chigaiso, Oniwakame Ezoi Shige: Ezoi Shige, Yabane Moku: Yabane Moku, Rappa Moku: Rappa Moku, Joromoku: Ugano Moku, Jo Lomoku, Hiemoku, Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumata Moku, Umitora no Moku, Fushishimoku, Mohmokumoku, Hahamokumoku , Ukimo: Ouokimo, Burukimo: Burukimo, Kayamonori: Kayamonori, etc.).

  Red algae Genus: Sea urchins, Tsukumonori, Anemone crickets, Astragalus, Amaranthus, Amaranthus, Agaricata Genus: Tamaitadaki, Kaikekenori Genus: Kaginori, Kaikekenori, Tengusa: Himetengususa, Hytengususa, Oobusa, Nambugu , Kohira, Yohira, Kinukusa, Hibirodo: Hibirodo, Himebiro, Isomumedo: Isommedo, Aedes: Rhizome, Ryumons: Ryumon, Ranunculaceae, Nisekare Naminohana: Hosobanaminohana, Naminohana, Sangomodoki: Ragaramomodoki, Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwanawa, Kinokawa: Kinokawa, Kanonote, Sangori Kyono Shiro, Sakuranori, Nikumukade, Tambanori, Tsurutsuru, Fudarak, Marubahdarak, Isonohana: Nurakusa, Ronulaksa, Oomkadenori, Hirakintoki: Hirakintoki, Matabou: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Rice, Tokamatsu, Hitomatsu, Fushikintoki, Tsunomude, Nagakinito, Crayfish Nagaobane: Naganobane, Funori genus: Hanafonori, Fukurofunori, Mafunori, Karekigusa: Karekigusa, Tosakamodoki: Hosobanatosakamodoki, Hironotosakamodoki, Yatsudegatatosakamodoki, Kurotosakamodokisane, Zotosofomoza Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, Hoonoo: Honoo, Hikagenoit: Hikagenoit, Usuginu, Nikuhounoo: Nikuhounoo, Venus nago, Venus nago, Susca veni: Suscabeni, Okarugusa: Yamadagusa, Mirin: Mirin, Hosokamiso , Isomocca genus: Isomocca, Yukari genus: Yukari, Hosoyukari, Ibaranori genus: Ibaranori, Saidaibara, Tachiibara, Kagibaranori, Kojinoo: Kizino-o, Isodantsu: Isodantsu, Atsubanori: Atsubanori, Ogonori, Ogonori, Ogori Mizo-okonori, birch, beniogonori, fukureshinori, purple birch, shinkaibanori, spruce birch, kataogonori, ryukyuogono Li, Atlantic scorpion, Ivy genus, Yumigataonori, Kubireogonori, Mosagogonori, Kinubanori, Amanita genus: Hachijotensamodoki, Fushikenori genus: Fushikenori, Namiiwatake, Nymphalanthus Itagususa, Saimi, Hari, Lotus Jigusa: Lotus Jigusa, Sugi nori: Ikanoashi, Hosoibonori, Nobonori, Black Haginansou Genus: gourd, cherries, octopus: octopus, sedge, genus: genus, genus: goat, dals : Dulse, Scorpionus, Anadalus, Weibusa: Uebusca, Benifronori: Benifuronori, Fusunagi: Futsutsunagi, Himefusunagi, Hirohafushitsugi, Otsunagisou, Hirawatagigi, Usuwasugi , Egonori: Egonori, Futogigi, Saeda: Saeda, Chirimomiji: Chirimomiji, Konohori family: Habutaenori, Konohori, Suzuronori, Usubeni: Genus: Kagios banori, Yareus banori, Susius banori, Heius banori, Usubanorimodoki: Usubanorimodoki, Ayanishiki genus: Ayani Genus: Aeginu, Dadia: Enasidadia, Shimadadia: Isohagi, Shimadadia, Dajimodoki: Dajimodoki, Euglena: Morayogusa, Fuyugusa, Makuri: Makri, Yanaginogi, Yuna, Yukinagina , Sasabayanaginori, Sozo genus: Kurosozo, Kobsozo, Hanesozo, Sozonohana, Hanegusa genus: Hananegusa, Hananegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoshigusu, Giant genus Isomagusa, Suginasugusa: Suginasusa, Isobasho: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Haezaki Sawflower, Kawamoku : Kawamoke, Aokawa Mozuku, Himekawa Mozuku, Ideyugogome: Ideyugogome, Okichimozuku: Okichizu, Otosa, Chinomo: Chinomo, Chisujinori, Chisujinori, etc.).

  Axial algae (Shajikumo, Shiratamamo, Hoshitsurimo: Hoshitsurimo, Rikunotumusu, Flaskmo: Himebumo, Chaboflasmo, Tripera, etc.), yellow algae (Hikarimo: Hikarimo, etc.), etc.

  In addition, the materials derived from animal materials include chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig brain tissue Extracts, cattle / pig or fish collagen hydrolyzate (acid, alkali, enzyme etc.) degradation products, water-soluble collagen or collagen derivatives such as acylated collagen, cow or pig elastin or elastin hydrolyzate (acid, alkali, Enzymes etc.) or water-soluble elastin derivatives, keratin and its degradation products or their derivatives, silk proteins and their degradation products or their derivatives, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (Hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or their derivatives, skim milk powder and their degradation products or their inducements Body, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.

  In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, etc. derived from a gene recombinant or a cell fusion can be used. Furthermore, for example, an undifferentiated cell group, a cell group in the middle of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can also be used.

(14) Marine components Seawater such as deep seawater, for example, sea salt, dried seawater, inorganic salt (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (from the Dead Sea or Atlantic Ocean) Fango), for example, Italian mud, German fungo, Eifelfango, Freiburg fungo, etc. Sea mud or mud from various locations (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, Magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, etc.

(15) Microbial culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermentation extract , Fermented rice bran (red rice bran, white birch) extract, Euglena extract or decomposition product thereof or water-soluble derivative thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, fermented lactic acid bacteria of legumes, coconut plant Lactic acid bacteria fermented products.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, Bengala, black iron oxide, gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.

(18) UV absorber / blocker benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxy Dimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, Octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxycinnamic acid cinnamate) Til, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, Methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives , Camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative Body, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, talc, kaolin etc.

(19) Whitening agent Paraaminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative, Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, pearl oyster, clam, clam, mugwort, honeysuckle) , Kihada, dokudami, matsuhod, pearl barley, mussel, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankaishi, hamamelis, yamagwa, lifelong grass, bellflower, toshishi, zetsugo, gyu, mao, senkyu, dod Tsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(21) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether).

(22) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, Ogon, Japanese horsetail, Gentiana, Burdock, Sikon, Carrot, Camelis, Hop, Yokuinin, Odori-so, Semburi, Toki, Kinkakusen, Achacha, Hypericum, Cucumber, Tachytrum, Rosemary, Parsley).

(23) Astringents Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compounds) and the like.

(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.

(25) Antioxidants Vitamin C or salts thereof, stearic acid ester, vitamin E or derivatives thereof, nordihydrogua cetelenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole , Propyl gallate, sesamol, sesamorin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor β-carotene, plant extract (sesame culture cell, hamcha, hypericum, hamamelis, clove, melissa, birch, birch, salvia, rosemary, minamitenji, jitsu, ginkgo, green tea).

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or its Salt, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract, propolis, etc.

(28) Antibacterial / bactericidal / disinfectant Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, Sarashi powder, iodine compound, iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p -Chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ester Tanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether, Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkco chloride) Nium, benzethonium chloride, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal bio Tsu DOO, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, mini Sasanishiki extract, natto metabolite, natto extract, loofah water, birch (white birch) or red pine sap

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (eg, gongoid, hypericum, clara, mulberry leaves, keihi, genokosho, comfrey, salvia, elderberry, bodaiju, button pie), seaweed extract and the like.

(31) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, thio Glycolic acid and the like.

(32) Antiandrogens Follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, etc.

(33) Peripheral vascular blood flow promoter Vitamin E or derivatives thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitive element 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.

(36) Antiseborrheic agent Pyridoxine or a derivative thereof, sulfur, vitamin B6 and the like.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea and the like.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, Sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(39) Hair remover Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate) Strontium thioglycolate) and the like.

(40) Hair swelling agents such as ethanolamine, urea and guanidine.

(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, para Nitroorthophenylenediamine, paraphenylenediamine, paramethylamino Phenol, picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N -Phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diamino sulfate Diphenylamine, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, parasulfate sulfate Methylaminophenol, metaaminosulfate Diol, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfone Sodium acid, hematein, etc.

(42) Fragrance Natural animal fragrance such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, Cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot Spirit , Peru balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil, and other synthetic flavors Fragrance etc.

(43) Dye and Colorant Red Cabbage Dye, Red Rice Dye, Akane Dye, Anato Dye, Ikumi Dye, Turmeric Dye, Enju Dye, Krill Dye, Amber Dye, Caramel, Gold, Silver, Gardenia Dye, Corn Dye, Onion Dye , Tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin etc.

(44) Sweeteners Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.

(45) Others Hormones, sequestering agents, pH adjusters, chelating agents, antiseptic and antibacterial agents, cooling agents, stabilizers, emulsifiers, animal and vegetable proteins and their degradation products, animal and vegetable polysaccharides And its degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound treatment agents, foam increasing agents, thickeners, enzymes, purified water (electronic Water, small clustering, etc.), oral preparations, deodorizing / deodorizing agents, bittering agents, seasonings, etc. can be raised and used in combination with these to provide additive or synergistic effects of the present invention or other cosmetic effects. Improvement can be expected.

  In addition, about the method of addition to the cosmetic composition for acne of this invention, it may add previously, may be added in the middle of manufacture, and should just select it suitably considering workability | operativity.

  Hereinafter, production examples, test examples, and formulation examples will be described. However, the present invention is not limited to these examples.

(Production Example 1)
About 100 kg of a dried product of kobotan is heated and extracted with purified water (about 80 ° C.) for about 5 hours and filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 2.0% by mass).

(Production Example 2)
100 g of a dried product of kobotaru is immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain about 1.0 kg of an extract (dry solid content: about 0.1 to 2.0% by mass).

(Production Example 3)
100g of dried coconut starch is immersed in 70% ethanol solution, 70% 1,3-butylene glycol solution, 60% propylene glycol solution, or purified water (about 30 ° C), extracted at room temperature for 5 days and nights, and then filtered. Thus, about 1.0 kg of an extract (dry solid content: about 0.1 to 2.5% by mass) is obtained.

(Test 1) Lipase activity inhibition test The lipase activity inhibitory action was evaluated based on the lipase activity value based on the quantitative reaction of lipase in human blood as an index.

"Test method and evaluation method"
a. Sample A sample for the lipase activity inhibition test was subjected to the test using the extract obtained in Production Example 2 of the present invention (solid content concentration: adjusted to 0.3%).
b. Enzyme lipase The enzyme lipase (derived from porcine pancreas / manufactured by Sigma) was adjusted to 0.2 units.
c. Measurement of lipase activity A mixture of 40% sample, 50% 0.2 unit lipase, and 10% purified water was used as a specimen, and the test was performed according to the test method of Lipase Kit S (Dainippon Pharmaceutical Co., Ltd.). As a control, the extraction solvent concentration of the sample was used instead of the sample, and for each sample and control, the control was set to 100% by the difference in coloration from the blind in which the substrate was added after the reaction was stopped. Was used to determine the lipase activity inhibition rate (= lipase activity inhibition action), and the results are shown in FIG.

[Equation 1]
Lipase activity inhibition rate (%) = {1− (sample BALB unit / control BALB unit)} × 100

(Test results)
As shown in FIG. 1, it can be confirmed that the cobotanum extract of the present invention has a lipase activity inhibitory action and can be used as a lipase activity inhibitor.

(Test 2) Safety test (1) Skin primary irritation test The Hartley system was prepared so that the cobotanle extract obtained in Production Examples 1 to 3 had a solid content of about 1.0%, and the back was shaved. 0.03 ml was applied per 2 × 2 cm ² square of guinea pig (female, 3 mice per group, body weight 300-350 g) skin. Judgment was performed 24, 48, and 72 hours after application using the primary irritation scoring method with erythema and edema as indicators. As a result, in all animals, no erythema and edema were observed, and it was judged negative.

(Test 3) Safety test (2) Cumulative skin irritation test The cobotanum extract obtained in Production Examples 1 to 3 was prepared so that the solid concentration was about 1.0%, and this was shaved on the flank (2 × 4 cm ² ) 0.5 ml / per animal was applied to the skin of Hartley guinea pigs (female, 3 mice per group, body weight around 320 g) once a day, 5 times a week. Application was for 2 weeks, and shaving was performed on the last application day of each week. Judgment was made on the day of each application and the day after the last application by the scoring method of primary irritation using erythema and edema as indices. As a result, in all animals, no erythema and edema were observed for 2 weeks after application, and it was judged negative.

(Test 4) Safety test (3) Single-dose toxicity test The cobotanum extract obtained in Production Examples 1 to 3 was adjusted with purified water to a concentration of 12.5%. Before the test, ddy mice (male and female, 1 group, 5 animals, 5 weeks old) fasted for 16 hours were orally administered with a sonde, and the onset, degree, etc. of toxic symptoms were observed over time. As a result, no abnormalities were observed in all mice for 14 days, and no abnormalities were found in the anatomical results. Therefore, LD ₅₀ was 2,000 mg / kg or more, and judged to be a safe substance.

(Prescription example) Manufacture of acne cosmetic composition According to the above evaluation results, the formulation examples are shown below, but each formulation example may be produced by a conventional method in the production of each product and shows only the blending amount. It was. The present invention is not limited to these.

(Formulation Example 1) Milk Mass%
1.Squalane 5.0
2.Olive oil 5.0
3. Jojoba oil 5.0
4.Cetyl alcohol 1.5
5. Glycerin monostearate 2.0
6.Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) soorbitan monooleate 2.0
8.1,3-Butylene glycol 1.0
9.Glycerin 2.0
10. Kobotan extract from Production Example 2 5.0
11. Preservative (paraoxybenzoic acid ester) appropriate amount
12.Perfume appropriate amount
13. Residue with 100 purified water

(Formulation Example 2) Milk Mass%
1. Squalane 8.0
2. Jojoba oil 7.0
3.Glyceryl paraaminobenzoate 1.0
4.ethyl urocanate 1.0
5. Vitamin C phosphate magnesium salt 1.0
6.Cetyl alcohol 1.5
7. Glycerin monostearate 2.0
8.Polyoxyethylene (20) cetyl ether 3.0
9.Polyoxyethylene (20) soorbitan monooleate 2.0
10.1,3-Butylene glycol 1.0
11.Glycerin 2.0
12.1,2-Pentanediol 3.0
13. 70% ethanol extract of coconut krill leaves or stems 3.0
14. Scots pine cone 70% ethanol extract 3.0
15. Silk Protein Enzyme Decomposition Solution 5.0
16. Pig placenta water extract 1.0
17. Preservative (paraoxybenzoic acid ester) appropriate amount
18.Residual water 100

(Formulation Example 3) Cosmetic Oil Mass%
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Co button vine bark hot water extract 3.0
6. Dingji hot water extract 1.0
7. Grapefruit fruit or leaf hot water extract 3.0
8. Tochu Nakaba Hot Water Extract 3.0
9. Soybean seed hot water extract 1.0
10.Olive oil 1.0
11. Shea fat 1.0
12.Butylhydroxyanisole 0.1
13. Vitamin E derivative 0.1
14. Preservative (benzalkonium chloride) appropriate amount
15. Perfume (rose water) appropriate amount
16.Residue with 100 purified water

(Formulation example 4) Flexible lotion mass%
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Monolauric acid polyoxyethylene sorbitan (20E.O) 1.0
4.Ethanol 15.0
5. 30% ethanol extract of coconut krill leaves or stems 3.0
6. Bodaiju flower or fruit
50% 1,3-butylene glycol extract 5.0
7. Yuzu fruit 30% ethanol extract 1.0
8. Jacobe 30% ethanol extract 1.0
9. Stem or leaf 30% ethanol extract 1.0
10. 30% 1,2-pentanediol extract from yam peel or fruit 1.0
11. Kiwi fruit 50% ethanol extract 1.0
12.White birch sap 1.0
13. Antibacterial (Lactoferrin solution) appropriate amount
14. Preservative (paraoxybenzoic acid ester) appropriate amount
15. Fragrance (Western light load water) appropriate amount
16.Residue with 100 purified water

(Formulation Example 5) Astringent lotion
1.Sorbit 2.0
2. POE (20) oleyl alcohol 1.0
3.Ethanol 15.0
4.1,2-Pentanediol 3.0
5. Kobotan whole plant 50% 1,3-butylene glycol extract 3.0
6. Soybean leaves 50% 1,3-butylene glycol extract 2.0
7. Gentian whole plant 50% ethanol extract 2.0
8. Hamelis leaves or bark
50% 1,3-butylene glycol extract 1.0
9. Green tea leaf or stem 50% 1,3-butylene glycol extract 1.0
10. Yeast 50% 1,3-butylene glycol extract 1.0
11.Allantoin 0.2
12. Astringent (Zinc Sulfocolate) 0.2
13. Antibacterial and antiseptic (thiamin lauryl sulfate) appropriate amount
14. Fragrance (lavender water) appropriate amount
15. Residue with 100 purified water

(Prescription Example 6) Two-layer lotion (liquid to liquid type)
1. Squalane 8.0
2. POE sorbitan tetraoleate 0.3
3.Sorbit 1.0
4.Ethanol 15.0
5. 50% Propylene Glycol Extract from Coconut Kale Fruit 2.0
6.Rhizome rhizome or root bark
50% propylene glycol extract 2.0
7. Green tea leaf or stem 50% 1,3-butylene glycol extract 2.0
8. Whole plant 50% 1,3-butylene glycol extract 2.0
9. Sage whole plant 50% ethanol extract 1.0
10. Bodaiju flower or fruit 30% ethanol extract 1.0
11.Ascorbic acid 0.2
12. Astringent (calamine) 0.1
13. Preservative (phenoxyethanol) appropriate amount
14. Perfume (apple water) appropriate amount
15. Residue with 100 purified water

(Formulation example 7) Carmine lotion (liquid to solid type)
1.Glycerin 3.0
2.1,3-Butylene glycol 5.0
3.Ethanol 15.0
4. Iron oxide (Bengara) 0.2
5.Zinc oxide 0.5
6.Kaolin 2.0
7. Kobotan leaves or stem
50% propylene glycol extract 2.0
8. Citrus flower 50% propylene glycol extract 2.0
9. Shark root 50% propylene glycol extract 2.0
10. Usbania flower or leaf
50% propylene glycol extract 2.0
11. Chamomile flower 50% propylene glycol extract 2.0
12. Comfrey leaves and stems 50% ethanol extract 1.0
13. Porcine placenta enzymatic degradation solution 1.0
14. Silk protein alkaline solution 2.0
15.Camphor 0.2
16.Phenol 0.03
17. Preservative (photosensitive element 201 & 401) appropriate amount
18. Fragrance (Bodhi Tree Water) Appropriate amount
19.Residue with 100 purified water

(Formulation example 8) Pack mass%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
5. 50% glycerin extract from coconut vine branches and rhizomes 1.0
6. Raspberry fruit 50% diglycerin extract 1.0
7. Dingyo 50% Diglycerin Extract 1.0
8. Wenzhou tangerine peel 50% 1,3-butylene glycol extract 1.0
9.Green tea leaf hot water extract 1.0
10. Momoha Hot Water Extract 2.0
11. Pig placenta hot water extract 1.0
12. Preservative (paraoxybenzoic acid ester) appropriate amount
13. Perfume (rose water) appropriate amount
14. Residue with 100 purified water

(Formulation example 9) Peel-off pack mass%
1.Glycerin 5.0
2.Propylene glycol 4.0
3.Polyvinyl alcohol 15.0
4.Ethanol 8.0
5.Polyoxyethylene glycol 1.0
6. Pantothenyl ethyl ether 1.0
7. Co button vine flower or flower spike 50% glycerin extract 2.0
8. Safflower whole plant 50% ethanol extract 2.0
9. Dutch jellies (parsley) leaves or stems
50% ethanol extract 2.0
10. Eucalyptus leaf or stem 30% ethanol extract 2.0
11. Royal jelly 50% ethanol extract 1.0
12. Trehalose solution 1.0
13. Preservative (paraoxybenzoic acid ester) appropriate amount
14. Fragrance (camomile water) appropriate amount
15. Residue with 100 purified water

(Prescription Example 10) Cold cream mass%
1. Sarah Beeswax 11.0
2.liquid paraffin 22.0
3.Lanoline 10.0
4.Olive oil 5.0
5. Chamomile oil 5.0
6. Palm oil 5.0
7.borax 0.5
8. Kobotan seed extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
9. Achillea millefolium whole plant extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
10.White birch bark extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
11. Ginseng root 50% propylene glycol extract 2.0
12. Matsuhodo nuclei 50% 1,2-butylene glycol extract 1.0
13. Soybean seed water extract 1.0
14.Liquid shea fat 1.0
15.Dipotassium glycyrrhizinate 0.1
16. Preservative (Acrinol) 0.1
17. Fragrance (lavender water) appropriate amount
18.Residual water 100

(Formulation example 11) Emollient cream mass%
1.Stearic acid 2.0
2. Stearyl alcohol 7.0
3.Reduced lanolin 2.0
4.Squalane 5.0
5. Octyldodecanol 6.0
6. Polyoxyethylene cetyl ether (25E.O.) 3.0
7. Lipophilic glyceryl monostearate 2.0
8.Propylene glycol 2.0
9.1,2-Pentanediol 2.0
10. Hot button kneaded leaves or stem hot water extract 3.0
11.Dokudami leaf hot water extract 3.0
12. Shiso leaf 50% propylene glycol extract 2.0
13. Purple root
50% propylene glycol extract 2.0
14. Soybean seed natto fermentation liquid 1.0
15.Glycyrrhetinic acid 0.1
16. Porcine Placenta Enzymatic Decomposition Solution 1.0
17. Preservative (paraben) appropriate amount
18. Perfume (clove water) appropriate amount
19.Residue with 100 purified water

(Formulation example 12) Facial cleansing cream mass%
1.Myristic acid 25.0
2.Stearic acid 5.0
3. Tallow fatty acid 5.0
4.Propylene glycol 10.0
5.Potassium hydroxide 6.0
6. Palm oil fatty acid diethanolamide 6.0
7.Cobot lees rhizome 50% glycerin extract 1.0
8. Apple fruit 20% 1,3-butylene glycol extract 2.0
9. Kawara mugwort leaf 20% 1,3-butylene glycol extract 2.0
10. Rosehip fruit 30% ethanol extract 1.0
11.Kakkon hot water extract 2.0
12.Glycyrrhizic acid 1.0
13.Apricot kernel 0.1
14. Preservative (salicylic acid) 0.1
15. Perfume (today water) appropriate amount
16.Residue with 100 purified water

(Prescription Example 13) Face-wash cream%
1.Stearic acid 10.0
2.palmitic acid 10.0
3.Myristic acid 12.0
4.Lauric acid 4.0
5.Glycerin 18.0
6. dl-Pyrrolidonecarboxylate solution 1.0
7.Dioctyl adipate1.0
8.Cetostearyl alcohol 3.0
9.Triethanolamine 3.0
10.Ergocalcifer 1
11.Oleyl alcohol 1.5
12. Lanolin derivative (EO adduct) 1.0
13.Potassium hydroxide 6.0
14. Cobot kle extract from Production Example 2 5.0
15. Royal Jelly Extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extract)
16. Oil-soluble chamomile flower or leaf extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extract)
17. Oil-soluble licorice root or rhizome extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extract)
18. Royal Jelly Extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extract)
19. Edetate 2.0
20.Glycyrrhizic acid 1.0
21. Preservative (salicylic acid) 0.1
22. Fragrance (mugwort water) appropriate amount
23. Residue with 100 purified water

(Prescription Example 14) Body soap mass%
1.Potassium laurate 15.0
2.Potassium myristate 5.0
3.Propylene glycol 5.0
4. Kobotan leaves or stem
70% 1,3-butylene glycol extract 1.0
5.Oolong tea leaves 70% 1,3-butylene glycol extract 1.0
6. Toki rhizome 70% 2,3-butylene glycol extract 0.5
7. Wakame 70% 1,3-butylene glycol extract 0.5
8.Merirot flower or leaf
70% 1,3-butylene glycol extract 0.5
9. Achacha leaf or stem 70% 1,3-butylene glycol extract 0.5
10. Soybean seed natto fermentation liquid 0.5
11. Aloe pulp 70% ethanol extract 2.0
12.Polyethylene powder 0.5
13.Hydroxypropyl chitosan solution 0.5
14. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5
15 Monoammonium glycyrrhizinate 0.1
16. Preservative (undecylenic acid, phenol)
17.pH adjuster
18. Perfume (lavender water) appropriate amount
19.Residue with 100 purified water

(Formulation Example 15) Granule bath agent
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3. Borax 6.0
4. Kobotan leaves or stems hot water extract dry powder 3.0
5. Eucalyptus hot water extract dry powder 1.0
6. Peach leaf 70% ethanol extract dry powder 1.0
7. Silk Protein Enzyme Decomposition Dry Powder 1.0
8. Pigment (Gungjo Green) appropriate amount

(Formulation Example 16) Granule bath agent
1.Sodium bicarbonate 57.0
2.Anhydrous sodium sulfate 30.0
3. Borax 3.0
4. Kobanzuru whole plant hot water extract dry powder 3.0
5. Elderflower or berries hot water extract dry powder 1.0
6. Kawara mugwort leaf or stem hot water extract dry powder 1.0
7. Wenzhou tangerine peel or fruit 50% ethanol extract dry powder 1.0
8. Peach leaf 70% ethanol extract dry powder 1.0
9. Persimmon leaves or roots 70% ethanol extract dry powder 1.0
10. Apple juice powder 1.0
11. Dye (Gunjou, chromium hydroxide) appropriate amount
12. Perfume (boiled water) appropriate amount

(Prescription Example 17) Coating Protective Agent A gauze or liniment cloth is impregnated with a prescription liquid in which an appropriate amount such as cobotle fruit or leaf hot water extract, antibiotics, anti-inflammatory agent, etc. is mixed and attached to the wounded part. Alternatively, the coconut krill fruit or leaf hot water extract may be directly sprayed locally and covered with gauze or the like.

(Test 5) Use effect test The effect at the time of actually using the cosmetic composition for acne of this invention was examined. The use test was conducted by 10 adult females 20 to 40 years old suffering from acne, eczema, and rough skin. Each day, twice a day in the morning and at night, after the face wash, the emulsion of Formula 1 (appropriate amount) was applied to the face for 3 months. It was performed by coating. As a control, the one prepared by removing the cobotanum extract of the present invention from the emulsion in the same manner was used. The evaluation method is based on the following criteria, and the results are as shown in Table 1. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.

"Skin disease improvement effect"
Effective: Acne, eczema and rough skin were improved.
Slightly effective: Acne, eczema and rough skin were slightly improved.
Invalid: No change before use.

(Test results)
As shown in Table 1, it was confirmed that the cosmetic composition for acne containing the lipase activity inhibitor containing the cobotanum extract of the present invention improves acne, eczema and rough skin.

It is a figure which shows the lipase activity inhibitory effect of the cobotanum extract of this invention.

Claims (1)

A cosmetic composition for acne, comprising a lipase activity inhibitor containing a coconut koji extract.

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