KR102215827B1 - Natural herbal composition for acne improvement and a method of manufacturing the same - Google Patents

Abstract

The present invention relates to a composition for alleviating acne containing a natural herbal composition, and a manufacturing method thereof. More specifically, the present invention relates to a technology which contains a Rosa rugosa extract and a Juncus balticus extract as active components, and provides excellent effects on antibacterial, antioxidant, skin detoxification, and blood circulation to suppress inflammatory reaction caused by acne bacteria, thereby providing beneficial effects in the prevention and treatment of acne.

Description

Natural herbal composition for acne improvement and a method of manufacturing the same}

The present invention relates to a composition for improving acne comprising a natural herbal extract and a method of manufacturing the same. In more detail, as an active ingredient, it contains extracts of berry and sirloin, and provides excellent effects on antibacterial, antioxidant, skin detoxification and blood circulation to suppress inflammatory reactions caused by acne bacteria, thereby providing beneficial effects in the prevention and treatment of acne. It is about.

Acne is caused by the action of hormones, bacterial infections, and excessive sebum secretion. It refers to an inflammatory skin disease in which hairs, rashes, and deep boils are blocked on the face, neck, chest, back, and shoulders.

The exact cause of acne is not known, but multiple causes work rather than one cause. The first is the excessive secretion of sebum. Sebum is a substance secreted by the sebaceous glands, and in normal amounts, it prevents harmful substances from outside the skin from penetrating between keratinocytes.However, under conditions such as puberty, before and after menstruation, early pregnancy, taking contraceptives, stress, etc. Represents a different hormonal balance. The changed hormonal balance stimulates the sebaceous glands, which leads to excessive secretion of sebum. In addition, there are cases where there is a lot of sebum secretion genetically, and it may be increased by a change in external temperature or an increase in skin temperature due to incorrect eating habits.

Second, the second cause is an infection of the pores. Excessively secreted sebum contains a lot of fatty acids, which raises the pH of the skin's surface and dissolves the skin's lipids, thereby lowering the skin's own defense. On the surface of the skin where the pH is increased, the acne causative bacteria easily proliferate, and the proliferated acne bacteria induce purulent inflammation through the weakened skin.

In addition, it is known that in addition to the above-mentioned causes, the causes of occurrence are very complex and various because they are affected by stress, irregular eating habits, and physical or mental conditions.

On the other hand, looking at the process of acne, in the initial stage, excessively secreted sebum accumulates in the pores, and the inside of the blanket expands under the pressure of sebum and becomes a comedo, and the clogged pores become white pimples, and the ends of the pores are slightly open. What appears black becomes black pimples. As the acne progresses further, the bacteria inflame the skin, resulting in red, millet-like red papules, which fester and become pustules with pus.

In order to treat such acne, conventionally, a method of inhibiting or removing acne bacteria using antibiotics has been used, but this has a problem of destroying normal skin flora and proliferating antibiotic-resistant bacteria. In addition, since excessive sebum secretion, one of the main causes of acne, cannot be controlled, there is a limitation as a fundamental acne treatment method. Accordingly, acne treatment has been performed by controlling sebum secretion by using a female hormone, but hormone drugs have serious side effects due to disturbance of human homeostasis, and there is a problem that it cannot be used continuously. Furthermore, acne usually accompanies inflammation without exception, and purulent inflammatory acne leaves a permanent mark on the skin from puberty to adults, so it is essential to suppress the inflammatory reaction for desirable treatment of acne. The situation is dependent only on the antibacterial effect.

Therefore, in recent years, research on the prevention and treatment of acne using natural extracts is increasing. For example, there is a study using an extract of barberry. Plum blossom refers to the freshly bloomed flower of the Rosaceae plant, Rosa rugosa Thunb. In particular, the flower that just bloomed in May is referred to as plum blossom, and is used for the treatment of hematopoiesis, harimenorrhea, and dysentery. Fruits are used to recover from fatigue and root Is used in folk remedies for the treatment of diabetes (Namba (1994) The encyclopedia of Wakan-yaku (traditional Sino-Japanese Medicines) which color pictures Vol (II). Hoikuaha, Tokyo. p.118), and recently glycosylated pulp and seeds. It has also been reported that the extract affects bone formation-related cells (韓資植誌 23(2):157~164(2010) Korean J. Plant Res. (2010.04.16.)).

In addition, it relates to a composition for the prevention and treatment of liver disease containing the extract of mae mae hwa as an active ingredient, wherein the extract mae hwa extract inhibits phosphorylation of Smad molecules by the transforming growth factor beta 1 (TGF-β1) that increases when hepatocytes are damaged. By confirming that the inhibitory effect is excellent and does not cause toxicity to normal cells, it has been disclosed that it can be used as an active ingredient in a liver disease therapeutic agent or a health functional food for preventing liver disease (Korean Patent Registration No. 10-1898411 , 2018.09.06).

However, other effects related to acne other than the above-described effects have not been known until now. Accordingly, the present invention has been completed after a long period of research in order to provide for the improvement of acne as the main active ingredients, such as barberry and sirloin.

An object of the present invention is to provide a natural herbal composition for improving acne.

It is an object of the present invention to provide an effect of preventing and treating acne by suppressing excessive secretion of sebum, which is the main cause of acne, and suppressing inflammatory reactions caused by acne bacteria, including the extracts of berry and sirloin root as active ingredients.

According to an embodiment of the present invention, there is provided a natural herbal composition for improving acne, comprising the extract of maekkaethwa extract and sirloin herb extract as active ingredients.

In addition, the composition may further include at least any one or more from pomegranate extract, clove extract, yellow lotus extract, golden extract, gosam extract and Sangbaekpi extract.

According to an embodiment of the present invention, there is provided a pharmaceutical composition for the prevention and treatment of acne comprising the composition.

In addition, according to an embodiment of the present invention, (a) preparing a mixture comprising a medium mass, sirloin and a solvent; (b) heating and pressing the mixture to prepare an extract; And (c) filtering and separating the extract; there is provided a method for preparing a natural herbal composition for improving acne comprising.

The natural herbal extract composition according to the present invention includes the extract of buckwheat and sirloin herb as an active ingredient, and provides an effect of suppressing excessive secretion of sebum, the main cause of acne. Therefore, by suppressing the inflammatory reaction caused by acne bacteria, it provides a beneficial effect in the prevention and treatment of acne.

In particular, the natural herbal extract composition according to the present invention provides an excellent antibacterial effect against Propionibacterium acnes and Cutibacterium acnes.

The natural herbal extract composition according to the present invention provides an effect of improving blood circulation and turning the complexion of the skin to improve skin trouble symptoms.

1 is a photograph of the result of confirming the antibacterial effect according to Experimental Example 1 of the present invention.
2 is a photograph of the result of confirming the antibacterial effect according to Experimental Example 2 of the present invention.
3 is a photograph of the result of confirming the antibacterial effect according to the comparative example of the present invention.

Hereinafter, specific contents and possible implementation examples for the implementation of the present invention will be described. However, with respect to the configuration not specifically specified below, unless contrary to the purpose of the present invention, content known in the art may be applied.

In the present specification, when a certain part in the present specification "includes" a certain component, it means that other components may be further included rather than excluding other components unless specifically stated to the contrary.

According to an embodiment of the present invention, there is provided a natural herbal composition for improving acne, comprising the extract of maekkaethwa extract and sirloin herb extract as active ingredients.

According to an embodiment of the present invention, the plum blossom refers to a flower of the Rosaceae plant, Rosa rugosa Thunb., and in particular, a flower that just bloomed in May is referred to as a plum blossom to treat hematopoiesis, harimenorrhea, and dysentery. It is known that the fruit is used in fatigue recovery, and the root is used in home remedies for diabetes treatment. Ingredients contained in the cultivation include citronellol, geraniol, nerol, eugenol, phenyl ethyl alcohol and quercitrin, which are essential oils. ), tannin, gallic acid, etc. By acting on the liver and spleen, it releases stagnation, improves blood circulation in the skin by passing through Gi-hyeol, and turns the complexion of the skin, helping to prevent and treat acne.

According to an embodiment of the present invention, the perennial sirloin (Juncus effusus L. var. decipiens Buchen. = juncus decipiens (Buchen.) Nakai) belongs to the rush family, as a stem core or outpost of rush and related plants of the genus, lake, lake. It is called vinegar, red sirloin, sirloin, jasperokcho, soot sirloin, iron sirloin, low-silence vinegar, and night seokcho. It is known that the core of the stem contains fiber, fatty acids, and proteins, and the stem contains polysaccharide components. In particular, it provides pharmacological action such as anti-inflammatory, antipyretic, diuresis, and hemostasis as a part of the gorge of rush (soft inside from which the hard shell of rush is removed).

Therefore, in the present invention, the main effective extract is sirloin, which provides an effect of improving the blood circulation of the skin by passing through Gi-hyeol, and including the extract of sirloin vinegar which provides an effect such as excellent anti-inflammatory or hemostasis, etc. can do.

In particular, according to an embodiment of the present invention, based on 100 parts by weight of the berry extract, the sirloin extract includes 25 to 75 parts by weight, and can provide an excellent improvement effect against acne bacteria. For at least one or more strains selected from Staphylococcus epidermidis, Staphylococcus aureus, Propionibacterium acnes and Cutibacterium acnes. It provides excellent antibacterial activity effect. This can be confirmed through the embodiments described later and FIGS. 1 and 2.

According to an embodiment of the present invention, the composition is provided with a natural herbal composition for improving acne further comprising at least one or more from a pomegranate extract, a cloves extract, a yellow lotus extract, a golden extract, a Gosam extract, and a Sangbaekpi extract.

In the case of the pomegranate peel, pomegranate (pomegranate or Punica granatum L.) is a deciduous lobster belonging to the pomegranate family, and has been widely used as a medicinal herb by drying the bark of fruits, stems and roots since ancient times, and it is native to southwest Asia and northwestern India. In addition, the biologically active ingredients and chemical ingredients are contained in the seeds, flesh, and skin of a pomegranate, so they are regarded as power fruits or functional fruits. Pomegranate skin, such as pomegranate skin, has anti-aging, anti-inflammatory and anti-inflammatory effects.

The clove is a volatile oil and fruit obtained by distilling the flowers or flowers of clove, which is a Myrtaceae plant, and has a warm nature, spicy taste, and no poison. It warms the stomach and removes alcohol poisoning and poisoning, and heals various boils. In addition, it has excellent antioxidant effect and removal of harmful oxygen.

The gold (Scutellaria baicalensis) is the dried root of the perennial herb (Scutellaria baicalensis EORGI), which is a perennial herb belonging to the Lamiaceae family, and has low toxicity, and about 30 species of flavonoid-based compounds are isolated. As the pharmacological action of gold, antipyretic action, diuretic action, antiviral action, antibacterial action, sedation action, anti-inflammatory action, anti-allergic action, antioxidant action and cell immunity promoting action are provided.

Sophora flavescens has a botanical name of a thief's staff because of the shape of its roots. It has a peculiar odor, is persistent, and is very bitter and cold. It is used for dysentery, lobster, prenatal pruritus, skin itching due to moist heat and pharmacological effects such as leukopenia treatment and anti-radioactivity, coronary artery blood flow increase, anti-tumor, antibacterial, and immune function suppression.

The Sangbaekpi (Morus　alba　L.) means a mulberry tree, specifically, it means the bark of a mulberry tree. It is used as a medicinal herb, and has antipyretic and diuretic effects, so it is used as a remedy for bronchitis, edema, and beriberi. In addition, in the case of the extract of the extract, it provides effects such as maintaining the structure of the stratum corneum and improving the skin barrier function.

Therefore, the natural herbal composition according to the present invention may further include at least any one or more from pomegranate peel, cloves, yellow lotus, gold, gosam and Sangbaek peel as an extract. In this case, with respect to 100 parts by weight of the plum extract, 20 to 40 parts by weight of pomegranate extract, 20 to 40 parts by weight of clove extract, 20 to 40 parts by weight of Coptisium extract, 10 to 30 parts by weight of golden extract, 5 to 15 parts by weight of Gosam extract By providing, including 1 to 10 parts by weight and 1 to 10 parts by weight of the extract of cortex, it provides antibacterial, antioxidant, and anti-allergic effects to help prevent and improve acne treatment. In addition, since it can provide effects of blood circulation and removal of harmful oxygen, skin trouble symptoms can be improved. Furthermore, when the natural extracts are included, they are derived from natural sources, which have been used as herbal medicines for a long time, so they are of course relatively safe even when used for a long time.

According to an embodiment of the present invention, the extract means that the extract is extracted from a natural product using an appropriate solvent, and in this case, the extract includes both a polar solvent and a non-polar solvent.

As the solvent, an alcohol having 1 to 4 carbon atoms including purified water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether , Benzene (benzene), chloroform (chloroform), ethyl acetate (ethyl acetate), methylene chloride (methylene chloride), hexane (hexane) and at least one selected from cyclohexane (cyclohexane) is provided.

In addition, it is apparent to those skilled in the art that the extract of the present invention can obtain an extract exhibiting substantially the same effect even when using not only the above extraction solvent but also other extraction solvents. Furthermore, the extract of the present invention includes not only the extract by the above-described extraction solvent, but also an extract that has undergone a conventional purification process. For example, through various additional purification methods, such as separation using an ultrafiltration membrane having a certain molecular weight cut-off value, separation by various chromatography (made for separation according to size, charge, hydrophobicity or affinity). The obtained active fraction is also contained in the extract of the present invention.

According to an embodiment of the present invention, the extract is characterized in that the extract is obtained by at least one of a supercritical extraction method, a hot water extraction method, an ethanol extraction method, and a methanol extraction method, and is preferably obtained by a hot water extraction method. .

In the supercritical extraction method, a dried and crushed sample and ethanol are used as a solvent and put into a supercritical fluid extraction reactor, and the temperature in the reactor is about 65°C, the pressure is 450 bar, and the S/F ratio (supercritical fluid kg/Feed kg) 35 It means a method of extracting under the conditions of

The hot water extraction method means that hot water is extracted by heating at a temperature of 50°C to 120°C for 10 to 36 hours, and the extracted extract is filtered through a filter to obtain a liquid.

The ethanol extraction method refers to the step of extracting the natural oriental herbal raw material with ethanol, and after the extraction is filtered using a filter net, the concentration is reduced under reduced pressure.

The methanol extraction method refers to the step of extracting the natural oriental herbal raw material with methanol, and after the extraction is filtered using a filter network, the concentration is concentrated under reduced pressure.

According to an embodiment of the present invention, the extract may be prepared in a powder state by additional processes such as distillation under reduced pressure and freeze drying or spray drying after extraction.

According to one embodiment of the present invention, there is provided a pharmaceutical composition for preventing and treating acne comprising the natural herbal composition. In this case, in the pharmaceutical composition for preventing and treating acne, Staphylococcus epidermidis, Staphylococcus aureus, Propionibacterium acnes and Cutibacterium acne (Cutibacterium acnes), characterized in that it has antibacterial activity against at least one or more strains selected from, and preferably provides an excellent antibacterial effect against Propionibacterium acnes and Cutibacterium acnes. Since it has a specific antibacterial activity against the above specific strains, it is possible to provide an excellent antibacterial effect without inducing widespread use. The antibacterial effect can be confirmed visually in the photos of FIGS. 1 and 2.

According to an embodiment of the present invention, the pharmaceutical composition for preventing and treating acne acne comprising the natural herbal composition is injection, granule, powder, tablet, pill, capsule, suppository, gel, suspension, according to a conventional method. Any one formulation selected from the group consisting of emulsions, drops or liquids may be used.

According to an embodiment of the present invention, the pharmaceutical composition for preventing and treating acne is an appropriate carrier, excipient, disintegrant, sweetener, coating agent, swelling agent, lubricant, lubricant, flavoring agent, antioxidant commonly used in the manufacture of pharmaceutical compositions. It may further include one or more additives selected from the group consisting of agents, buffers, bacteriostatic agents, diluents, dispersants, surfactants, binders, and lubricants.

On the other hand, according to an embodiment of the present invention, (a) preparing a mixture, including a medium mass, sirloin and a solvent; (b) heating and pressing the mixture to prepare an extract; And (c) filtering and separating the extract; there is provided a method for preparing a natural herbal composition for improving acne comprising.

First, according to an embodiment of the present invention, (a) preparing a mixture including burying, sirloin and a solvent; is provided, and in this case, herbal materials such as cultivation or harvesting You can use it after drying in the sun or in the shade, and you can purchase and use the product that is commercialized and sold. The prepared herbal ingredients can be finely pulverized and then mixed with a solvent. The pulverization may be provided for effective mixing, and the size of the pulverized material may be provided in a size of 18 to 25 mesh.

In addition, in the case of the provided solvent, an alcohol having 1 to 4 carbon atoms including purified water, methanol, ethanol, propanol, isopropanol, butanol, etc., acetone, At least one or more selected from ether, benzene, chloroform, ethyl acetate, methylene chloride, hexane, and cyclohexane can be provided. have.

In the step (a), preferably, each dried oriental herbal material is mixed with the crushed and sirloin vinegar, and the sirloin sirloin contains 25 to 75 parts by weight based on 100 parts by weight of the crushed herb before preparation of the mixture. When the edulis and sirloin are provided in the above ranges, sirloin vinegar extracts that provide an effect such as anti-inflammatory or hemostasis may be included to more effectively improve acne. The solvent provides 1 to 50 parts by weight of 1 to 50 times the total dry weight of the sirloin and sirloin before the preparation of the mixture, so that sufficient extraction may proceed.

Furthermore, the mixture of step (a) may contain at least one or more of pomegranate peel, cloves, yellow lotus, golden, gosam, and Sangbaek peel as herbal ingredients. In this case, with respect to 100 parts by weight of lumped, pomegranate skin 20 to 40 parts by weight, cloves 20 to 40 parts by weight, Coptis Coptis 20 to 40 parts by weight, gold 10 to 30 parts by weight, Gosam 5 to 15 parts by weight, and Sangbaek skin 1 to 10 It is provided including parts by weight. Accordingly, the natural herbal composition provided by the present invention provides a particularly excellent antibacterial effect against Propionibacterium acnes and Cutibacterium acnes.

Next, according to an embodiment of the present invention, (b) heating and pressing the mixture to prepare an extract; is provided. For example, the heating and pressurization may be extracted by heating at a temperature of 50° C. to 120° C. for 10 to 36 hours. In addition, extraction may be obtained by at least one of a hot water extraction method, an ethanol extraction method, and a methanol extraction method. Preferably, a hot water extraction method is provided.

Finally, according to an embodiment of the present invention, (c) filtering and separating the extract; is provided. In the case of the filtration, at least one method selected from a filter cloth, a filter paper, and a vacuum filtration device may be used. For example, the extracted extract can be separated after filtering using a filter cloth. The separated extract may be finally prepared in a powder state by an additional process such as concentration under reduced pressure, distillation under reduced pressure, freeze drying or spray drying, if necessary. The freeze-drying may be performed, for example, from -50°C to -30°C in stages for 24 to 72 hours to obtain a dry powder. Accordingly, a natural herbal composition for improving acne according to the present invention can be finally provided.

Hereinafter, the present invention will be described in more detail using Examples and Comparative Examples. It goes without saying that these examples are provided for the purpose of illustrating the embodiments of the present invention more specifically, and are not intended to limit the scope of the present invention.

[Example]

<Example 1: Preparation of natural herbal composition for improving acne by hot water extraction>

Including 100 g of dried plum blossoms, 50 g of sirloin, 30 g of pomegranate, 30 g of cloves, 30 g of Coptis chinensis, 20 g of gold, 10 g of Gosam and 5 g of Sangbaek extract were pulverized into particles of about 18 mesh, and then distilled water of 8 times the weight of the material Mix with, boil for 3 hours in a hot water extractor including a cooling condenser, extract, cool at room temperature, and filter the herbal particles with a 380 mesh filter cloth. Next, it was filtered through a 10 μm paper filter. The filtrate was filtered in a reduced pressure filter using a 0.45 μm membrane filter, and then freeze-dried to prepare a natural herbal composition for improving final acne.

<Example 2: Preparation of natural herbal composition for improving acne by ethanol extraction>

Including 100 g of dried plum blossoms, 50 g of sirloin, 30 g of pomegranate, 30 g of cloves, 30 g of Coptis chinensis, 20 g of gold, 10 g of Gosam and 5 g of Sangbaek extract were pulverized into particles of about 18 mesh, and then ethanol of 8 times the weight of the material. It was mixed with and extracted for 3rd time standing at room temperature for 3 days. After extraction, the herbal particles are filtered with a 380 mesh filter cloth. Next, it was filtered through a 10 μm paper filter. The filtrate was filtered in a reduced pressure filter using a 0.45 μm membrane filter, and then freeze-dried to prepare a natural herbal composition for improving final acne.

<Comparative Example>

For comparison, an extract was prepared in the same manner as in Example 1 using the following herbal medicines, and a test solution was prepared at 10 mg/mL (10,000 ppm), and the agar medium diffusion method was performed according to the methods of Experimental Examples 1 and 2. The used medicinal materials were Jigolpi, Jisil, Dermis, Changija, Cheongung, Cheonnyeonja, Cheonhwabun, Cheongpi, Cheongho, Osu, Jeobaekpi, Chungwoolja, Gardenia, and Taekran respectively.

<Experimental Example 1>

In order to measure the antimicrobial activity of the test substance against Propionibacterium acnes, an agar medium diffusion method was performed. Propionibacterium acne was diluted to 10 ⁸ CFU/ml in Oxoid CM 149 Reinforced clostridial medium liquid medium, dropped 100 µl into Oxoid CM 149 Reinforced clostridial medium solid medium, and smeared using a sterilized disposable spreader. After drying for 10 minutes, 100 µl of Example 1 was dropped onto a sterilized 10 mm paper disc, dried for 5 to 10 minutes, and then placed on the Oxoid CM 149 Reinforced clostridial medium solid medium coated with the experimental strain. After the gas pack was added, it was sealed and incubated in a 37°C incubator for 72 hours to observe a clear zone generated around the paper disc. The observation results for this are shown in FIG. 1.

<Experimental Example 2>

In order to measure the antimicrobial properties of the test substance against Cutibacterium acnes, an agar medium diffusion method was performed. After diluting Cutibacterium acne at 10 ⁸ CFU/ml in Oxoid CM 149 Reinforced clostridial medium liquid medium, drop 100 µl into Oxoid CM 149 Reinforced clostridial medium solid medium, and then smear using a sterilized disposable spreader, 5-10 After drying for minutes, 100 µl of Example 1 was dropped onto a sterilized 10 mm paper disc, dried for 5 to 10 minutes, and then placed on the Oxoid CM 149 Reinforced clostridial medium solid medium coated with the experimental strain. After the gas pack was added, it was sealed and incubated in an incubator at 37° C. for 72 hours to observe a clear zone generated around the paper disc. The observation results are shown in FIG. 2.

In Figures 1 and 2, which are the results according to Experimental Examples 1 and 2, a transparent ring was observed around the paper disc of the composition according to the embodiment of the present invention, whereby the acne causative bacteria Propionibacterium acnes and Cutibacterium acnes (Cutibacterium acnes) was able to confirm the antibacterial effect. On the other hand, looking at Figure 3, which is a result of using various herbal medicines of Comparative Example, no transparent ring was found, and it was confirmed that the antibacterial effect was insignificant compared to the Example.

Therefore, the natural herbal extract composition according to the present invention includes the extract of berry and sirloin root as active ingredients, it is possible to confirm the effect of suppressing excessive secretion of sebum, which is the main cause of acne, and inhibiting the reaction of acne bacteria. Thus, it can be confirmed that it can provide a beneficial effect in the prevention and treatment of acne.

In addition, the herbal composition according to the present invention possesses specific antimicrobial activity against Propionibacterium acnes and Cutibacterium acnes, so it can provide excellent antibacterial effects without inducing widespread use. You can see that you can.

As described above, although the present invention has been described by a limited embodiment, the present invention is not limited to the above embodiment, which is a person of ordinary skill in the field to which the present invention belongs, various modifications and variations from these descriptions It is possible. Accordingly, the spirit of the present invention should be grasped only by the claims set forth below, and all equivalent or equivalent modifications thereof will be said to belong to the scope of the spirit of the present invention.

Claims (14)

It contains as an active ingredient a plum blossom extract, a sirloin extract, a pomegranate extract, a clove extract, a yellow lotus extract, a golden extract, a gosam extract, and a serrata extract,
With respect to 100 parts by weight of the plum extract, the sirloin extract is 25 to 75 parts by weight, 20 to 40 parts by weight of pomegranate extract, 20 to 40 parts by weight of clove extract, 20 to 40 parts by weight of yellow lotus extract, 10 to 30 parts by weight of golden extract , Natural herbal composition for improving acne, comprising 5 to 15 parts by weight of Gosam extract and 1 to 10 parts by weight of Sangbaekpi extract. delete delete delete delete A pharmaceutical composition for preventing or treating acne comprising the composition of claim 1. delete (a) preparing a mixture comprising plum blossom, sirloin, pomegranate peel, cloves, yellow lotus, gold, gosam, sangbaek skin, and a solvent;
(b) heating the mixture to prepare an extract; And
(c) filtering and separating the extract; including,
In the step (a), based on 100 parts by weight of the dried crushed berry before preparing the mixture, 25 to 75 parts by weight of sirloin vinegar, 20 to 40 parts by weight of pomegranate skin, 20 to 40 parts by weight of cloves, 20 to 40 parts by weight of Coptis, 10 to gold 30 parts by weight, 5 to 15 parts by weight of Gosam and 1 to 10 parts by weight of Sangbaek skin,
The solvent of the step (a) is a method for preparing a natural herbal composition for improving acne, characterized in that it contains 1 to 50 parts by weight of 1 to 50 times the dry weight part of sirloin and sirloin before the preparation of the mixture. delete delete delete delete delete delete

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