KR20160003914A - Cosmetic composition for anti-inflammation or improving skin trouble containing herb extracts - Google Patents

Abstract

The present invention relates to a composition for anti-inflammation or trouble treatment comprising a herbal medicinal extract and, more specifically, to a cosmetic composition comprising one or more extracts or fractions of the same selected from the group consisting of ginseng, Typha angustata, Cinnamomi Cortex, Paeonia lactiflora, Rehmannia glutinosa, Angelica gigas Nakai and a mixed extract or fractions thereof as active components for improving skin elasticity or reducing wrinkles.

Description

TECHNICAL FIELD The present invention relates to a cosmetic composition for anti-inflammation or improving skin trouble containing herb extracts,

More particularly, the present invention relates to a cosmetic composition for improving anti-inflammation or trouble, comprising an extract of a medicinal herb, and more particularly, to a cosmetic composition containing at least one extract or fraction thereof selected from the group consisting of ginseng, carrot, broiler, peony, As an active ingredient, to a cosmetic composition for improving anti-inflammation or trouble.

Inflammation is the immune response of the body in response to a wound or disease. Oxidative stresses such as ultraviolet rays, active oxygen, and free radicals activate inflammatory factors and cause aging of various diseases and skin. The vasoactive polypeptide, kinin, plasmin and complement, have vasodilatory and contraction and chemotaxis effects, as well as lymphokines such as interleukin-6 (IL-6) Phosphorus and arachidonic acid are responsible for inflammation. Arachidonic acid is metabolized through inflammatory mediators such as prostaglandin and leuko triene through two pathways: cyclooxygenase or lipooxygenase, mediating a variety of inflammatory responses.

On the other hand, a substance that acts to eliminate inflammation and to reduce vital signs and symptoms to eliminate inflammation is called an anti-inflammatory agent. To date, there have been a number of nonsteroidal anti-inflammatory drugs, including flufenamic acid, ibuprofen, benzydamine, indomethacin, prednisolone, , Dexamethasone, and the like. It is also known that allantoin, azene, hydrocortisone and the like are effective for antiinflammation. However, these materials are limited in their use due to safety of skin, .

Under these circumstances, the inventors of the present invention conducted studies on substances that are not toxic to naturally occurring natural resources and have excellent skin condition-improving effect, and thus, they are classified into a group consisting of ginseng, aphids, broilers, peonies, As an effective ingredient has been shown to exhibit the NO production inhibitory effect, and a composition for improving anti-inflammation or trouble using the same has been completed.

[Patent Literature]

(Patent Document 1) Korean Patent Registration No. 10-0954984

(Patent Document 2) Korean Patent Publication No. 10-1309172

The object of the present invention is to provide a cosmetic composition for improving anti-inflammatory or anti-inflammatory properties, which comprises as an active ingredient at least one extract or a fraction thereof selected from the group consisting of ginseng, carrot, broiler, peony, .

In order to solve the above problems, an embodiment of the present invention is characterized by comprising at least one extract or a fraction thereof selected from the group consisting of ginseng, carrot, broiler, peony, To provide a cosmetic composition for improving anti-inflammation or trouble.

In another embodiment of the present invention, there is provided a cosmetic composition for improving anti-inflammation or trouble, comprising as an active ingredient, a mixed extract of ginseng, carrot, broiler, peony, mulberry, golden and angelica or a fraction thereof.

In another embodiment of the present invention, the mixing ratio of the ginseng, rice plants, broiler chick, peony root, mulberry root, golden and Angelica ginseng is 10 to 30:10 to 30:10 to 20:10 to 20:10 to 20 : 10 to 20: 3 to 15.

In another embodiment of the present invention, the blending ratio of the ginseng, rice plants, broiler chickens, peony mosses, ginseng, golden and angelica is 15 to 20:15 to 20:15 to 15:12 to 15:12 to 15 : 6 to 10;

The ginseng radix of the present invention refers to a root of perennial herb belonging to the genus Araliaceae ginseng (Panax). Preferably, ginseng can be dried. Ginseng is a typical medicinal plant, and its growth rate is very slow. Therefore, it takes 4 to 6 years to grow enough ginseng. The main active ingredient of ginseng is known as a complex carbohydrate (a complex of alcohol or phenol and sugar) called saponin or ginsenosides. These ingredients are central nervous system excitatory and sedative actions, metabolic control, blood sugar reduction, muscle activity, endocrine system excitement, hormone concentration and maintains appropriate. Especially, saponin of ginseng is a triterpenoid saponin which is a unique saponin existing only in ginseng plant. Plant saponins have hemolytic action, especially the saponin component of ginseng is a neutral glycoside with little toxicity.

Typha angustifolia of the present invention means a perennial herb belonging to Typhaceae . In the present invention, it is particularly possible to dry the ear area of the baby's feet. They grow in the water of a river or a pond, about 1.5 meters tall, rootstock is long side by side, and stem is straight with a cylindrical shape. Leaves are linear, about 80 ~ 100cm long, and the bottom covers the stem. Flowers hang apart from male flower ear and female flower ear. Flowers have white hairs on the bottom and no corollas. Male flower has three anthers and pollen is yellow. The stigma is linear. The soft leaves are used for weaving cushions, and the pollen is called 黃 黄 (黃 黄).

The broiler system of the present invention means the bark of Cinnamomum cassia belonging to the genus Lauraceae . In the present invention, broiler chickens can be used by drying. The bark of the broiler is collected between August and October, and it is dried and used in the musk. It is a medicinal substance which is spicy and sweet and has a good nature to communicate with the blood of our body. It is a medicinal substance which helps the circulation of our body. It has central inhibition, soothing, analgesic, antipyretic, increase of coronary blood flow and inhibition of skin fungi. Diarrhea, vomiting, menstrual irregularities, menstrual cramps, postpartum hemorrhagic abdominal pain, boils, skin ulcers, and limb paralysis.

The peony of the present invention is a perennial herbaceous plant belonging to Ranunculaceae ( Paeonia < RTI ID = 0.0 > albiflora ). Preferably, the dried peony can be used. Peonies are painkillers, antipyretics or diuretics. The main ingredients are paeonoside, paeoniflorin, β-sitosterol, paeonine, gallotanin, benzoic acid, astragalin, etc. .

The marshmallow of the present invention means a root of Ophiopogon japonicus , a perennial herb, belonging to Liliaceae . Preferably, McMundong can be dried. MacMundong is particularly good for diabetes, and it is also used for anti-inflammation, diuretic, antibacterial, antipyretic, tonic, shampoo expectorant, and cardiovascular medicine.

The gold of the present invention means the root of perennial herbarium ( Scutellaria baicalensis ) belonging to the Labiatae . Preferably, the dried gold can be used. Gold is used for edible, industrial, mulberry, ornamental, etc. It is used for cheongryeotwu (淸 热 濕 燥), poisoning, anthrax, gastritis, enteritis, jinhae and is used as an antiinflammatory agent,

The Angelica gigas of the present invention means the root of Angelica gigas , a perennial herb, belonging to the Umbelliferae . Preferably, the dried Angelica gigas can be used. Angelica is one of the most commonly used medicinal herbs. It is used for hemorrhage, blood flow congestion, swelling and pain caused by bruise, sprain, vascular disease, blood circulation deficiency, physical weakness, joint pain, headache, abdominal pain, dizziness, constipation, The main medicinal herbs are menstrual control and calm.

The term "extract" used in the present invention refers to an extract obtained by extracting the above ginseng, broiler chickens, broilers, peonies, mackerel ducks, golden ginseng or a mixture thereof, a diluted solution or a concentrated solution of the extracted solution, Extracts of all the formulations which can be formed using the extract itself and the extract, such as the obtained dried product, the adjusted product or the purified product of the extracted solution, or a mixture thereof.

The extract of the present invention can be extracted from natural, hybrid, or mutant plants of the respective plants, and can also be extracted from plant tissue cultures.

In the extraction of the ginseng, the pygmies, the broiler, the peony, the ginseng, the golden ginseng, the ginseng, or the mixture thereof according to the present invention, the extraction method is not particularly limited and the extraction may be carried out according to a method commonly used in the art . Non-limiting examples of the extraction method include hydrothermal extraction, ultrasonic extraction, filtration, and reflux extraction. These may be performed alone or in combination with two or more methods.

In the present invention, there is no particular limitation on the kind of extraction solvent used for extracting the ginseng, Arabidopsis, broiler, peony, mulberry, golden, angelica or mixture thereof. Any solvent known in the art can be used have. Non-limiting examples of the extraction solvent include water; C ₁ to C ₄ lower alcohols such as methanol, ethanol, propyl alcohol and butyl alcohol; Polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; And hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture thereof. Water, lower alcohol, 1,3-butylene glycol, and ethyl acetate may be used alone or in admixture of two or more. In the present invention, water (or distilled water), 1,3-butylene glycol, or a mixed solvent thereof may be used as a solvent for extracting the medicinal herbs of ginseng, carrot, broiler, peony, . The solvent extract may be prepared by extracting at least one time of herbal medicines of ginseng, pomegranate, broiler, peony, myeonmundong, gold, and angelica. The solvent extract may be subjected to vacuum distillation, A dry extract can be prepared. In one specific embodiment of the present invention, ginseng extract using an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4); Anabudae extract; Broiler chick extract; Peony extract; Marshmallow extract; Golden extract; Angelica gigantosa extract; And two kinds of mixed extracts of ginseng, carrot, broiler, peony, mungum-dong, golden and angelica were prepared (Examples 1 to 9).

In the present invention, the extract obtained by heat extraction or cold extraction is filtered to remove suspended solid particles by filtration, for example, nylon or the like, or filtered using a freezing filtration method or the like, Spray drying and the like.

The term "fraction " as used herein means a product obtained by performing fractionation to separate a specific component or a specific component group from a mixture containing various components.

The fractionation method for obtaining the fraction in the present invention is not particularly limited and may be carried out according to a method commonly used in the art. As a non-limiting example of the above-mentioned fractionation method, there is a method of obtaining a fraction from the extract by treating a predetermined solvent with an extract obtained by extracting ginseng, carrot, broth, peony, have.

The kind of the solvent used for obtaining the fraction in the present invention is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the fraction solvent include polar solvents such as water and alcohol; And non-polar solvents such as hexane, ethyl acetate, chloroform, and dichloromethane. These may be used alone or in combination of two or more. When alcohols are used in the fraction solvent, C ₁ to C ₄ alcohols can be preferably used.

The ginseng extract of the present invention can be used to effectively inhibit the production of nitrogen monoxide (N0), thereby exhibiting anti-inflammatory or anti-trophic effects, such as ginseng extract, broodstock extract, broiler chick extract, peony extract, mungumun dong extract, In addition, since the composition of the present invention is a substance derived from a natural material, it is not toxic and can be used as a cosmetic composition without adverse effect even when it is applied to a human body.

Inflammation reaction is a mechanism to regenerate damage due to physical action, harmful substance, chemical stimulation, bacterial infection as a part of defensive reaction of biotissue to external stimuli. Persistent inflammation causes rather mucosal damage and promotes damage, inflammation and skin troubles in skin tissue.

Macrophages play a crucial role in the immune response and control a variety of inflammatory mediators, including nitric oxide, prostaglandins, and inflammatory cytokines, the immune proteins. Among them, nitrogen monoxide plays an important role in killing bacteria or removing tumors, but excessive nitric oxide production by pathogen causes inflammation, and inflammation induces skin trouble.

In other words, inhibition of the production of mononuclear mononuclear nitric oxide can prevent, alleviate, ameliorate and treat skin inflammation and prevent, alleviate, improve and treat skin troubles caused by inflammatory reaction.

Specifically, in the case of using each of the ginseng extract, Aiguibudae extract, broiler chick extract, peony extract, mungmun dong extract, golden extract, angelica giganti extract or mixed extract thereof, monoclonal antibodies It was confirmed that nitrogen production was suppressed (Example 10).

Particularly, the extract of the mixture or the fraction thereof containing all of the ginseng, the pomegranate, the broiler, the peony, the moxon dong, the golden and the angelica of the present invention can be obtained by the synergistic effect or the cooperative action between the extracts and / Compared with L-NMMA (L-NG-Monomethylarginine), which is a known inhibitor of nitrogen monoxide production, it has been shown to inhibit the production of nitric oxide from macrophages It was confirmed that there was a very strong inhibitory effect on nitric oxide production equivalent to or more than that, which was first identified in the present invention.

Specifically, the extract of the present invention containing the ginseng, the pygmy goby, the broiler chrysanthemum, the peony root, the golden ginseng, the golden ginseng and the ginseng extract or the fractions thereof is superior to the single extract of the ginseng, the pygmaea, the broiler, It is possible to further enhance the ability to inhibit nitrogen monoxide production and consequently to exhibit a better anti-inflammatory or skin-trouble-improving effect.

In the present invention, the mixing ratios of the ginseng, rice plants, broiler chickens, peony root, mulberry roots, golden roots and Angelica ginseng are preferably 10 to 30:10 to 30:10 to 20:10 to 20:10 to 20:10, To 20: 3 to 15, more preferably 15 to 20: 15 to 20: 15: 15: 12 to 15: 12 to 15: 6 to 10.

According to a specific embodiment of the present invention, the mixed extract of 15: 15: 15: 15: 15: 15: 10 and the mixture ratio of 20: 20: 15 are mixed with the ginseng, broodstock, broiler, : 15: 12: 12: 6, and their degree of inhibition of nitrogen monoxide formation was investigated. As a result, the degree of inhibition of nitrogen monoxide formation was found to be higher than that of the extracts of ginseng, Chinese cabbage, broiler, peony, (Example 10).

The term "anti-inflammatory" as used in the present invention means all actions in which the immune response is alleviated and NO production is inhibited.

As used herein, the term "Trouble " means skin conditions such as skin rash, acne, pimples, and red nose which may be caused by inflammation caused by excessive nitric oxide production in macrophages.

The term "improvement of trouble" used in the present invention refers to inhibiting or inhibiting the generation of troubles in the skin, or alleviating the trouble already generated.

The cosmetic composition of the present invention can be used as a cosmetic composition in the form of a solution, a topical ointment, a cream, a foam, a nutritional lotion, a softening lotion, a pack, a soft water, a latex, a makeup base, But are not limited to, those selected from the group consisting of solutions, pastes, gels, lotions, powders, soaps, surfactant-containing cleansing, oils, powdered foundations, emulsion foundations, wax foundations, patches and sprays no.

The cosmetic composition of the present invention may further comprise at least one cosmetically acceptable carrier to be incorporated in a cosmetic composition for general skin. Examples of the cosmetic composition include ordinary ingredients such as oil, water, a surfactant, a moisturizer, a lower alcohol, , A chelating agent, a coloring agent, a preservative, a perfume, and the like may be appropriately compounded, but the present invention is not limited thereto.

The cosmetically acceptable carrier contained in the cosmetic composition of the present invention varies depending on the formulation of the cosmetic composition.

When the formulations of the present invention are ointments, pastes, creams or gels, the carrier component may be an animal oil, a vegetable oil, a wax, a paraffin, a starch, a tracer, a cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc, zinc oxide May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder and the like may be used as a carrier component. In particular, But are not limited to, propellants such as rocaborn, propane / butane or dimethyl ether. These may be used alone or in combination of two or more.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent may be used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, Propylene glycol, 1,3-butyl glycol oil and the like can be used, and particularly fatty acid esters of cottonseed oil, peanut oil, corn oil, olive oil, castor oil and sesame oil, glycerol aliphatic ester, polyethylene glycol or sorbitan May be used, but is not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, but are not limited thereto. These may be used alone or in combination of two or more.

When the formulation of the present invention is a soap, use is made of an alkali metal salt of a fatty acid, a fatty acid hemiester salt, a fatty acid protein hydrolizate, isethionate, a lanolin derivative, an aliphatic alcohol, a vegetable oil, glycerol, But is not limited thereto. These may be used alone or in combination of two or more.

In the cosmetic composition of the present invention, the medicinal herbal extract of ginseng, poultry, broiler, peony, mackerel, golden, angelica or mixture thereof may be contained in an amount of 0.0001 to 50% by weight of the total weight of the cosmetic composition, By weight, more preferably from 0.0005 to 10% by weight. There is an advantage of exhibiting excellent anti-inflammatory or skin trouble-improving effect within the above-mentioned range, and there is an advantage that the formulation of the composition is stabilized.

The composition of the present invention containing extracts of ginseng, carrot, broiler, peony, manggok-dong, golden, angelica or mixture thereof or fractions thereof is excellent in anti-inflammatory or skin troubles-improving effect. Specifically, the composition of the present invention is excellent in inhibiting the production of nitrogen monoxide in macrophages.

In addition, since the composition of the present invention is a substance derived from a natural substance, it has no toxicity and does not cause side effects even when it is applied to human body, and thus it is highly utilized as a cosmetic composition.

Hereinafter, the constitution and effects of the present invention will be described in more detail through examples. These embodiments are only for illustrating the present invention, and the scope of the present invention is not limited by these embodiments.

Example 1: Preparation of ginseng extract

The ginseng was dried and finely divided, and 100 g of dry weight was added to the flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days. The frozen extract was filtered with a filter having a pore size of 0.2 탆 to prepare a ginseng extract.

Example 2: Preparation of Angioptera extract

The dried eggplant pods were cut into small pieces and 100 g of dry weight was placed in a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare an extract of Aiguille.

Example 3: Preparation of broiler chick extract

The broiler was dried and cut into three pieces. 100 g of dry weight was put into a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The chilled extract was filtered with a filter having a pore size of 0.2 mu m to prepare a broiler chick extract.

Example 4: Preparation of peony root extract

The pellets were dried and finely divided, and 100 g of the dried weight was added to the flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare a peony root extract.

Example 5: Preparation of Macromolecular Extract

The mixture was dried and cut into small pieces. 100 g of dry weight was placed in a flask, and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare a mulberry extract.

Example 6: Preparation of golden extracts

After drying the gold, the dried weight of 100 g was put into a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 mu m to prepare a golden extract.

Example 7: Preparation of Angelica gigas Nakai extract

After the Angelica gigas was dried and cut into three pieces, 100 g of dry weight was put into a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered through a filter having a pore size of 0.2 탆 to prepare Angelica giganta Radix extract.

Example 8: Preparation of mixed extracts of ginseng, rice plants, broiler chickens, peony mosses, maekmundong, gold and Angelica gigas

(Ginseng 15g, ginseng 15g, broiler 15g, peony 15g, ginseng 15g, golden 15g, and ginseng 10g) after drying three kinds of dried ginseng, ginseng, And the mixture was extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 탆 to prepare a mixed extract of ginseng, aphids, broilers, peonies, ginseng, golden and angelica.

Example 9 Preparation of Mixed Extracts of Ginseng, Panax ginseng, Broiler, Peony, Maekmoongdong, Golden and Angelica ginseng

(Ginseng 20g, broiler chick 15g, broth 15g, peony 15g, gangmongdong 12g, gold 12g, angelica 6g) after drying three times, Was placed in a flask and extracted with 1000 g of an extraction solvent (distilled water: 1,3-butylene glycol = 6: 4) for 3 days by cooling. The frozen extract was filtered with a filter having a pore size of 0.2 탆 to prepare a mixed extract of ginseng, aphids, broilers, peonies, ginseng, golden and angelica.

Example 10: Investigation of anti-inflammatory effect by inhibition of NO production

In order to confirm the anti-inflammatory effect and the skin trouble relieving effect of the medicinal herb extracts of Examples 1 to 9, nitric oxide (NO) formation by GRIESS using RAW264.7 cell line (ATCC number: CRL-2278) Inhibition experiments were carried out.

Specifically, RAW264.7 cells, macrophages of mice, were subcultured several times, placed in 24-well plates at 3 × 10 ⁵ per well, and cultured for 24 hours. Subsequently, the herbal extract extracts prepared in Examples 1 to 9 were diluted with the concentrations shown in the following Table 1 and replaced with the cell culture medium containing them. At this time, L-NMMA (L-NG-Monomethylarginine), which is an inhibitor of NO production, was treated together as a positive control and cultured for 30 minutes. Lipopolysaccharide (LPS) 100 μl of the supernatant was transferred to a 96-well plate, and 100 μl of GRIESS solution was added thereto at room temperature for 10 minutes. The absorbance at 540 nm was measured to determine the NO inhibitory effect of the herb extract. Respectively. The experiment was repeated three times.

sample(%) NO production inhibition rate (%) Negative control group - L-NMMA (10 [mu] g / ml) 38.21 Example 1 (0.1%) 10.34 Example 1 (1.0%) 20.49 Example 2 (0.1%) 6.20 Example 2 (1.0%) 18.47 Example 3 (0.1%) 9.72 Example 3 (1.0%) 15.69 Example 4 (0.1%) 5.27 Example 4 (1.0%) 12.85 Example 5 (0.1%) 4.88 Example 5 (1.0%) 11.36 Example 6 (0.1%) 6.04 Example 6 (1.0%) 15.31 Example 7 (0.1%) 2.30 Example 7 (1.0%) 6.85 Example 8 (1.0%) 36.98 Example 9 (1.0%) 40.04

As can be seen from the results of Table 1, the ginseng extract, Aiguibule extract, broiler chick extract, peony extract, mangumun dong extract, golden extract, Angelica gigantus extract and mixed extracts of these herbal medicines have an effect of inhibiting NO production, Was more effective in inhibiting NO production than the herbal extract alone. In particular, when 7 kinds of herbal medicines were mixed by 20: 20: 15: 15: 12: 12: 6 on the weight basis, it was confirmed that the extract had an excellent NO production inhibitory effect similar to that of L-NMMA known as NO production inhibitor.

Manufacturing example  1: Preparation of an essence containing the mixed extract of the present invention

A cosmetic composition of an essence formulation was prepared as shown in the following Table 2 (unit: wt%).

Raw material name Content (% by weight) Cetearyl alcohol
Cetearyl glucoside
Jojoba seed oil
Silica
glycerin
Example 9 Extract
Purified water 2
One
5
0.5
10
5
To 100

Production Example 2: Production of a cream containing the mixed extract of the present invention

A cream form cosmetic composition was prepared as shown in Table 3 below (unit: wt%).

Composition Content (% by weight) Example 9 Extract
Stearic acid
ethanol
Potassium hydroxide
glycerin
Propylene glycol
antiseptic
incense
Purified water 5
15.0
1.0
0.7
5.0
3.0
Suitable amount
Suitable amount
to 100

Claims (7)

Wherein the extract comprises at least one extract or a fraction thereof selected from the group consisting of ginseng, carrot, carrot, peony, mackerel, golden and angelica as an active ingredient.
The cosmetic composition for improving anti-inflammatory or anti-inflammatory properties according to claim 1, which comprises, as an active ingredient, a mixed extract of ginseng, carrot, broiler, peony, mungumongdong, golden and angelica or fractions thereof.
The method according to claim 2, wherein the mixing ratio of the ginseng, rice plants, broiler chickens, peonies, ginseng, golden and angelica is 10-30: 10-30: 10-20: 10-20: 10-20: 20: 3-15. ≪ / RTI >
The method according to claim 2, wherein the blending ratio of the ginseng, the broodstock, the broiler, the peony, the ginseng, the golden and the ginseng is 15 to 20:15 to 20:15 to 15:12 to 15:12 to 15: 10. A cosmetic composition for improving anti-inflammation or trouble.
The method of claim 1, wherein the ginseng extract, Typha, chickens, peony, maekmundong, of one or more selected from a group consisting of gold and angelica root water, C ₁ to C ₄ lower alcohol, 1,3-butylene Glycols, and ethyl acetate. The cosmetic composition for improving anti-inflammation or trouble is characterized by being obtained by extracting with at least one solvent selected from the group consisting of water, ethanol, glycol, and ethyl acetate.
6. The cosmetic composition according to claim 5, wherein the solvent is water and 1,3-butylene glycol in a weight ratio of 6: 4.
The cosmetic composition according to claim 1, wherein the anti-inflammatory or anti-inflammatory effect is due to inhibition of nitrogen monoxide (NO) production.