JPH05255044A - Hair grower - Google Patents

Abstract

PURPOSE:To provide a hair grower having excellent hair growing effect. CONSTITUTION:The objective hair grower compaises at least one kind of extract of plant selected from Mallotus japonicus, Lamium album, Hedera tobleri, Smilacis glabrae rhizoma, Lycii radicis cortex, Tilia cordata, Hedera helix, Nupharis rhizoma, Arsaema spp., Trapa japonica, and Saussurea lappa.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent having excellent hair loss-preventing and hair-growing effects. The present invention is particularly used in the fields of medicines, quasi drugs, and cosmetics.

[0002]

2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. For this reason, conventional hair nourishing agents are generally blended with compounds having the action of removing or reducing the above causes. For example, vitamins such as vitamin B and vitamin E, serine,
Prevents alopecia by incorporating amino acids such as methionine, vasodilators such as assembly extracts and acetylcholine derivatives, purple root extract, anti-inflammatory agents such as hinokitiol, female hormone agents such as estradiol, and skin function enhancers such as cepharanthin. And used for treatment.

[0003]

However, in spite of various attempts as described above, conventional hair nourishing agents do not always have sufficient hair nourishing effects such as hair loss prevention and hair growth effect. It was This is probably because there are various causes of hair loss and the mechanism of hair growth is very complicated.

In view of the insufficient hair nourishing action as described above, the present inventor has searched for a substance which is effective against hair loss and has excellent hair loss preventing and hair-growing actions. As a result, they have found that a special plant extract has strong hair loss prevention, hair growth and hair growth effects, and completed the present invention.

[0005]

Means for Solving the Problems That is, the present invention is a plant extract or a kind of plant extract selected from Akamegasiwa, Altea, Odorichosou, Ivy, Sankirai, Zikoppi, Linden, Ivy, Senkotsu, Tennansho, Hisinomi and Mockweed. It is intended to provide a hair nourishing agent, which comprises two or more kinds as active ingredients.

The structure of the present invention will be described in detail below. Examples of the plant extract used in the present invention include red mulberry wrinkles (Mallotus japonica Mue).
ller Arg. ] Bark, Altea (Officialis)
L. ], Astragalus [Lamium album
L. ] Flowers, wickers [Hedera rhombea]
Leaves or trunk, Sankirai (Yamareki) [Smilax g
labra Roxburgh] tubers, Zicoppi (wolfberry, earth-bone skin) [Lycium chinense Mi
ller] root bark, linden [Tilia sylve]
stris L. ] Flowers, Ivy (Eternal spring ivy)
[Hedera helix] foliage, sengoku (kohone, river bone) [Nuphar japonicum D
e Candole] rhizome, Tennansho [Arisaemaheterophyllum]
Blume] tubers, Hisomi (Hishimi) [Trapa
japonica Flerov], Mokko (Saussurea lapa Clar)
ke] root and the like.

As a method for producing the herbal medicine extract used in the present invention, the herbal medicine is a solvent, for example, lower alcohol such as hot water, methanol, ethanol or the like, hydrous lower alcohol or propylene glycol, 1-3 butylene glycol and the like. It is obtained by extraction with hydrous alcohol such as polyhydric alcohol or hydrous polyhydric alcohol.

The amount of the plant extract in the present invention is preferably 0.005 to 20% by weight, and more preferably 0.01 to 5% by weight, based on the total amount of the hair nourishing agent.
If it is less than 0.005% by weight, the effect of the present invention is not sufficiently exhibited, and if it exceeds 20% by weight, it is not preferable in terms of formulation. The dose for transdermal administration cannot be clearly determined because it varies depending on age, individual differences, medical conditions, etc. Generally, the dose for human administration is 1 kg of body weight and 0.01 per day. ~ 100 mg, preferably 0.1
-10 mg, and this amount can be administered once a day or divided into 2 to 4 times a day.

The hair nourishing agent according to the present invention includes one or more kinds of plant extracts selected from the above-mentioned Akamega wrinkles, Altea, Odori Kosou, Kizuta, Sankirai, Zikoppi, Lindensis, Izukui, Senkotsu, Tennansho, Hishinomi and Mockweed. Besides, vasodilators such as carpronium chloride, assembly extracts and acetylcholine derivatives, amino acids such as serine and methionine, vitamins B6, vitamin E and its derivatives, vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhetinic acid and its Derivatives, nicotinic acid esters such as benzyl nicotinate, skin function-enhancing agents such as cepharanthin, female hormone agents such as estradiol, and the like may be mixed at the same time. Furthermore, additives usually used in hair nourishing agents, for example, hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanilide and antibacterial agents such as biothionol, cooling agents such as menthol, salicylic acid, Drugs such as zinc and its derivatives, lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols, glycerin, propylene Polyhydric alcohols such as glycols, other surfactants, fragrances, antioxidants, ultraviolet absorbers, dyes, ethanol, water, humectants, thickeners and the like may be appropriately blended within a range that does not impair the effects of the present invention. it can.

The hair nourishing composition of the present invention may be in any form as long as it has properties applicable to the outer skin such as liquid, emulsion and ointment.

[0011]

EXAMPLES Next, the production method and the hair-retaining action of the hair nourishing agent of the present invention will be described more specifically with reference to Examples. The present invention is not limited to this. The blending amount is% by weight.

Tables 1 to 1 show Examples 1 to 11 and Comparative Examples 1 and 2.
3 shows. The manufacturing method is shown below. Each plant extract (methanol extract) ion-exchanged water and hydrogenated castor oil ethylene oxide (40 mol) adduct were added to 95% ethanol, dissolved by stirring, and then ion-exchanged water was added and mixed to prepare the liquid form of Example 1. I got a hair nourishment. Examples 2 and 3 and Comparative Example 1 were also obtained in the same manner as in Example 1. Examples 4-11
In Comparative Example 2, a liquid hair nourishing agent was obtained without using hydrogenated castor oil ethylene oxide (40 mol) adduct.

[0013]

[Table 1]

[0014]

[Table 2]

[0015]

[Table 3]

(Hair Growth Test) The hair growth tests of Examples 1 to 11 and Comparative Examples 1 and 2 were carried out using C3H / He in the resting period of the hair cycle.
Using the NCrJ mouse, the method of Ogawa et al. (Normal and Abnormal Epidermal Differentiatio [Normal and Abnormal Epidermal Differentiatio
n], edited by M. Seiji and IABernstein, No. 159-170.
Page, 1982, University of Tokyo). That is, the number of mice was 10 per group, and there was no application, and the mice were divided into groups of Examples 1 to 11 and Comparative Examples 1 and 2, and the backs of the mice were shaved with a clipper and a shaver. 0.1 ml each was applied. The hair-growth effect of each sample was measured by measuring the hair-growth part on the back of the mouse and compared by area ratio. Table 4 shows the number of days required for 50% hair growth rate for each sample.

[0017]

[Table 4]

As described above, the hair nourishing agent according to the present invention is
It has an excellent hair growth effect.

(Hair nourishing test) Next, in order to examine the hair nourishing effects such as hair loss prevention and hair growth effect of the hair nourishing agent of the present invention, a trichogram test was conducted on humans. The hair nourishing agents of Examples 1 to 3 and Comparative Example 1 were used.

(Trichogram test) The hair roots of the removed hair before and after the use of the hair nourishing agent are observed under a microscope, and the number of resting hair roots is counted from the morphology of the hair roots. The effects were compared. Resting hair roots are hair roots of hairs that have stopped growing, and it has been recognized that people who complain of hair loss have a higher proportion of resting hair roots than normal people. Each hair nourishment of Examples 1 to 3 and Comparative Example 1 was applied to the scalp of 10 male subjects twice a day, 2 ml each, continuously for 6 months, immediately before and immediately after the application for 6 months. 100 hairs were removed from each subject, and each hair root was examined. The results are shown in Table 5.

[0021]

[Table 5]

As described above, the hair nourishing agent according to the present invention has an excellent hair nourishing action. In addition, in Examples 4 to 11, a practical use test was conducted on humans as in Example 1, and it was confirmed that the hair-feeding effect was excellent.

Example 12 (Phase A) Liquid paraffin 10.5 Glyceryl monostearate 3.0 EO (20 mol) -2-octyldodecyl ether 3.0 Propylparaben 0.3 Perfume 0.1 (Phase B) Dried ethanol extract of Akamega wrinkle 0.5 Glycerin 10.0 Dipropylene Glycol 18.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Ion-exchanged water 54.595 (Production method) Phases A and B are dissolved by heating and mixed, respectively,
The mixture was emulsified with a homomixer to obtain a creamy hair nourishing agent. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

Example 13 Dried product of ethanol extract of Kizuta 0.5 Dried product of 50% ethanol extract of Mokkou 0.3 Dried product of 50% methanol extract of Lindenia 0.1 Dried product of propanol extract of Zicoppi 0.1 Dried product of methanol of Tennansho 0.1% of Sengoku Ethanol extract dried product 0.03 hydrogenated castor oil ethylene oxide (40 mol) adduct 2.0 95% ethanol 54.0 ion-exchanged water balance (production method) Ion-exchanged water was added to 95% ethanol, and hydrogenated castor oil ethylene oxide (40 mol) adduct After adding, each plant extract is added and dissolved by stirring. When this hair nourishing agent was subjected to a practical use test on humans as in Example 1, it was confirmed that the hair nourishing effect was excellent.

[0025]

The hair nourishing agent of the present invention is a hair nourishing agent having an excellent hair nourishing effect.

Claims (1)

[Claims] Claims: 1. Akamegasiwa, Altea, Astragalus,
A hair nourishing agent comprising one or two or more kinds of plant extracts selected from Kizuta, Sankirai, Zikoppi, linden, Hizoki, Senkotsu, Tennansho, Hishinomi and Mokko.