JPH05310537A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic, comprising extracts prepared by extracting Isodon japonica Hara, Leonurus sibiricus L., Leonurus macranthus Maxim., Perilla frutescens Britton var. acuta Kudo, Perilla frutescens Britton f. viridis Makino, Perilla frutescens Britton var. crispa Decaisne viridi-crispa Makino, Perilla Britton var. japonica Hara and Perilla frutescens Britton var. citriodora Ohwi with an aqueous solvent and having strong action on prevention of alopecia and trichogenic and hair growing action. CONSTITUTION:The objective hair tonic is obtained by extracting the whole herb of Isodon japonica Hara, the whole herb and seeds of Leonurus sibiricus L., the whole herb of Leonurus macranthus Maxim., the whole herb and seeds of Perilla frutescens Britton var. acuta Kudo, the whole herb of Perilla frutescens Britton f. viridis Makino, the whole herb and seeds of Perilla frutescens Britton var. crispa Decaisne viridi-crispa Makino, the whole herb of Perilla frutescens Britton var. japonica Hara and a leaf and a stem of Perilla frutescens Britton var. citriodora Ohwi with an aqueous solvent and including one or two or more of the resultant plant extracts. The plant extracts used herein may directly be blended in a state of the extract solutions in the hair tonic or the extract solutions may be dried and blended therein. When the plant extracts are blended as dried substances, the amount of the extracts is preferably about 0.01-5wt.% in the total amount of the hair tonic. The hair tonic may be any of the forms of a liquid, an emulsion, an ointment, etc., and can be used as a hair tonic, a hair liquid, a scalp treatment, a hair cream, a shampoo, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing agent having excellent hair loss-preventing and hair-growing effects. The present invention is particularly used in the fields of medicines, quasi drugs, and cosmetics.

[0002]

2. Description of the Related Art Conventionally, the causes of baldness and hair loss are activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxides. Abnormalities of the scalp are considered. For this reason, conventional hair nourishing agents are generally blended with a compound having an action of removing or reducing the above-mentioned causes. For example, vitamins such as vitamin B and vitamin E, serine,
Prevents alopecia by blending amino acids such as methionine, vasodilators such as assembly extracts and acetylcholine derivatives, purple root extract, anti-inflammatory agents such as hinokitiol, female hormone agents such as estradiol, and skin function enhancers such as cepharanthin. And used for treatment.

However, in spite of various attempts as described above, conventional hair nourishing agents have not always been sufficient in hair nourishing action such as hair loss prevention and hair growth effect. It is considered that this is because the causes of hair loss are various and the mechanism of hair growth is extremely complicated. In view of the fact that the hair-feeding effect is insufficient as described above, the present inventor has searched for a substance that is effective against hair loss, has excellent hair loss prevention, and has a hair-growth effect for hair growth. ,
Swordfish, Kisewata, Perilla, Aojizo, Chirimendiso,
We have found that one or more plant extracts selected from perilla and lemon perilla have strong anti-hair loss, hair growth and hair growth effects, and have completed the present invention.

[0004]

Means for Solving the Problems That is, the present invention is to blend one or two or more plant extracts selected from Hikiokoshi, Swordfish, Kisewata, Perilla, Aojizo, Chirimendiso, Egoma and Lemon Egoma as active ingredients. The present invention provides a hair nourishing agent.

The structure of the present invention will be described in detail below. The following plant extracts are used as the plant extract used in the present invention. Hikiokoshi (Invoked, Enmeisou) [Isodon
[Japoneca Hara] whole plant, swordfish (eyelash, maternal mother grass) [Leonurus sibircus]
L. ] Whole plants and seeds, cottonweed (cotton) [Leo
nurus macranthus Maxim. ], The whole plant, perilla [Perilla frutesc]
ensBritton var. acuta Kud
o] whole plants and seeds, Aojiso (blue shiso) [Peri
lla frutescens Britton va
r. acuta Kudo formata riridi
s Makino] whole plants and seeds, Chile menjiso (red soup, red shiso) [Perilla frutesce
ns Britton var. crispa Dec
ne] whole plants and seeds, sesame seeds (Peri)
lla frutescens Britton va
r. japonica Hara] whole plant, lemon pergum [Perilla frutescens Brit
ton var. Citriodora Ohwi] leaves and stems are used. As a method for producing a plant extract used in the present invention, a plant is used as an aqueous solvent, for example, 0 ° C to 100 ° C.
Of water or a hydrous alcohol containing a lower alcohol such as methanol or ethanol, or a hydrous polyhydric alcohol containing a polyhydric alcohol such as propylene glycol or 1,3-butylene glycol.

The plant extract used in the present invention may be added to the hair nourishing agent in the state of the extract, or may be added as a dried product by drying the extract. When blended as a dry product, the blending amount is 0.005 to
It is 20% by weight, preferably 0.01 to 5% by weight. 0.005
If it is less than 20% by weight, the hair nourishing effect referred to in the present invention is not sufficiently exhibited, and if it exceeds 20% by weight, it is not preferable in terms of formulation.

The hair nourishing agent according to the present invention includes the above Hikioshi
Swordfish, Kisewata, Perilla, Aojizo, Chirimendiso,
One or more plant extracts selected from perilla and lemon perilla, vasodilators such as capronium chloride, cembly extract, acetylcholine derivatives, amino acids such as serine and methionine, vitamin B ₆ , vitamin E and its derivatives , Vitamins such as biotin, pantothenic acid and its derivatives, glycyrrhizic acid and its derivatives, nicotinic acid esters such as benzyl nicotinate,
A skin function enhancer such as cepharanthin and a female hormone agent such as estradiol may be simultaneously added. Furthermore, additives usually used for hair nourishing agents, for example, hinokitiol, hexachlorophene, benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, antibacterial agents such as trichlorocarbanilide and biothionol,
Cooling agents such as menthol, salicylic acid, zinc and its derivatives, agents such as lactic acid and its alkyl esters, organic acids such as citric acid, amino acids such as arginine, olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids, and higher fatty acids. Oil such as alcohol, polyhydric alcohol such as glycerin and propylene glycol,
Other surfactants, fragrances, antioxidants, UV absorbers,
Dyes, ethanol, water, moisturizers, thickeners and the like can be appropriately added within a range that does not impair the effects of the present invention.

The hair nourishment of the present invention may be in any form as long as it can be applied to the scalp such as liquid, emulsion or ointment, and is generally called hair tonic, hair liquid, scalp treatment, hair cream, shampoo and the like. It can take the form of a product. Further, the dose of the hair nourishing agent of the present invention cannot be definitely determined because it varies depending on age, individual difference, medical condition, etc. However, in general, the dose for administration to humans is 1 kg of body weight and 0.01 to 100 mg per day, preferably Is 0.1 to 10 mg, and this amount is once a day or 2 to
It can be administered in four divided doses.

[0009]

EXAMPLES The hair nourishing action of the present invention will be described more specifically with reference to the following examples. The present invention is not limited to this. In order to confirm the effect of the present invention, hair growth was evaluated using the following test method.

[Hair Growth Test] Examples 1 to 6 and Comparative Example 1
~ 4 hair growth test with C3H / HeN in resting phase of hair cycle
Using a CrJ mouse, the method of Ogawa et al. (Normal and Abnormal Epidermal Differentiatio
n], edited by M. Seiji and IABernstein, 159-17.
0 page, 1982, University of Tokyo). That is, the back of a mouse in the hair resting period on the 60th day after birth was shaved with a hair clipper and a shaver, and sample application was performed once a day from the next day every day, and the change in the area ratio of the part where hair regeneration started was determined The speed of reproduction was compared. The hair regrowth area was measured by imaging the back skin and using a digitizer.
The samples are examples (6 examples) containing the plant extract according to the present invention and comparative examples (4) in which the plant extract is replaced with purified water.
Example) Ten mice were used for each sample, and 0.1 ml of each sample was applied once a day in a size of 2 × 4 cm. The hair growth effect of each sample was compared by obtaining the average value of the change rate of the hair growth part of each solid. The results of the hair regeneration area after 20 days for each sample are shown in Table 1 in percentage.

[Hair nourishing test] Next, in order to investigate the hair nourishing action such as hair loss prevention and hair growth effect of the hair nourishing agent of the present invention, a hair loss conversion test was carried out. Subject with male pattern baldness 3
The conversion rate from downy hair to terminal hair before and after the application of each sample was compared at each of 3 head and downy hair areas of 0 persons. Here, the terminal hair refers to hair other than downy hair, that is, hair having a length of 14 mm or more, and the conversion from downy hair to terminal hair means a hair nourishing effect. Immediately before the start of application of each sample and immediately after the end of application for 4 months, macrophotographs of the downy hair regions were taken to obtain the average value of each individual, and the conversion rate was measured. The conversion rate of terminal hair after application for 4 months is shown in Table 1 in percentage.

[00012]

[Table 1] ──────────────────────────────────── Sample Hair growth test (mouse) Hair growth test (Human) Evaluation of regenerated area after 20 days Evaluation of average end-of-hair conversion rate ───────────────────────────────────── Example 1 (Hikiokoshi) 59% Effective 24.0 Effective Comparative Example 1 12 Ineffective 2.4 Ineffective Example 2 (Makijiki) 36 Effective 19.0 Effective Comparative Example 2 10 Ineffective 2.2 Ineffective Example 3 (Excited, messy) Valid Valid, Ecoma) 68 28.4 Comparative Example 3 16 Invalid 2.5 Invalid Example 4 (Kisewata) 28 Valid 18.0 Valid Comparative Example 4 14 Invalid 1.9 Invalid Example 5 (Lemon Egoma) 34 Valid 20. 5 Effective Example 6 (Perilla, Aozo) 72 Effective 30.1 Effective ────────── ────────────────────────────

Example 1 Heartnic (% by weight) (1) Hydrogenated castor oil EO (40 mol) adduct 2.0 (2) Hikokoshi 70% EtOH extract / dried product 15.0 (3) 95% ethanol 70. 0 (4) Perfume proper amount (5) Purified water is added to bring the total amount to 100. [Production Method] (1), (2) and (4) were added to (3), and the mixture was stirred and dissolved, and then (5) was added to obtain a hair nick of Example 1. Comparative Example 1 From the formulation of Example 1, the component of (2) was replaced with purified water to obtain Comparative Example 1.

Example 2 Heartnic (% by weight) (1) Glycerin 2.0 (2) L-menthol 0.1 (3) Phellinus 70% EtOH extract / dried product 5.0 (4) 95% ethanol 60. 0 (5) Perfume proper amount (6) Purified water is added to bring the total amount to 100. [Manufacturing Method] (1), (2), (3) and (5) were added to (4), and the mixture was stirred and dissolved, and then (6) was added to obtain a hair nick of Example 2. Comparative Example 2 From the formulation of Example 2, the component (3) was replaced with purified water to obtain Comparative Example 2.

Example 3 Heartnic (% by weight) (1) Polyethylene glycol 200 2.0 (2) L-menthol 0.2 (3) Hikiokoshi water extract 5.0 (4) Swordfish water extract 5.0 (5) Perilla water extract 5.0 (6) 95% ethanol 50.0 (7) Perfume proper amount (8) Purified water is added to bring the total amount to 100. Comparative Example 3 Comparative Example 3 was prepared by substituting the components (3), (4), and (5) from the formulation of Example 3 with purified water.

Example 4 Hair Liquid (wt%) (1) Polyoxypropyl butyl ether (40PO) 15.0 (2) Polyoxypropyl butyl ether phosphoric acid (40PO) 15.0 (3) Xewata 70% EtOH extraction and drying Substance 0.01 (4) 1,3-butylene glycol 5.0 (4) 95% ethanol 50.0 (5) Perfume proper amount (6) Dye, edetic acid proper amount (7) Purified water is added to bring the total amount to 100. To do. Comparative Example 4 Comparative Example 4 was prepared by substituting the component (3) from the formulation of Example 4 with purified water.

Example 5 Scalp treatment (% by weight) (1) 1,3-propylene glycol 0.5 (2) pentaerythrol tetra-2-ethyl hexanate 1.2 (3) 95% ethanol 60.0 (4) ) Lemon-Egoma 70% EtOH extraction / dried product 10.0 (5) Assembly extract 1.0 (6) Perfume proper amount (7) Add DME / LPG (95/5) to make the total amount 100.

Example 6 Hair Cream Phase A (% by Weight) (1) Liquid Paraffin 5.0 (2) Cetostearyl Alcohol 5.5 (3) Vaseline 5.5 (4) Glyceryl Monostearate 3.0 (5 ) EO (20 mol addition) -2-octyl dimethyl ether 3.0 (6) Vitamin E acetate 0.05 (7) Propylparaben 0.3 (8) Perfume 0.05 Phase B (9) Perilla polyhydric alcohol content 70% EtOH extract 10.0 (10) 70% EtOH extract containing Aoshiso polyhydric alcohol 10.0 (11) Glycerin 7.0 (12) Dipropylene glycol 20.0 (13) Polyethylene glycol 4000 5.0 (14) Sodium hexametaphosphate 0.005 (15) Purified water is added to bring the total amount to 100. [Manufacturing Method] Phase A was melted by heating and mixed, to which the heat-melted mixture of phase B was added and emulsified with a homomixer.

[0019]

As shown in Table 1, the hair nourishing agent according to the present invention showed a remarkable hair nourishing effect in the hair growth test (mouse) and the hair growth test (human).

Claims (1)

[Claims] Claims: 1. Hikiokoshi, Swordfish, Kisewata, Perilla,
A hair nourishing agent containing one or more plant extracts selected from blue-green algae, chilli menjiso, perilla, and lemon perilla.