JPH09227342A - Hair-tonic and hair-growing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair-tonic and hair-growing agent exhibiting excellent effect for preventing the falling off of hair, hair-tonic effect and hair-growing effect and having safety over a long period by compounding a cytotonic agent or a blood circulation promoting agent together with an extract of a specific plant. SOLUTION: A cytotonic agent or a blood circulation promoting agent is used in combination with an extract of Geranium nepalense. The Geranium nepalense extract is obtained by drying the whole grass of the aerial part of Geranium nepalense of the family Geraniaceae, cutting the dried grass to proper size and extracting with a solvent. The amount of the Geranium nepalense extract to be compounded to the agent is preferably 0.001-10wt.%. The cytotonic agent is, e.g. pantothenic acid and its derivative (pantothenyl ethyl ether), ginseng extract, biotin or mononitroguaiacol and the blood circulation promoting agent is, e.g. carpronium chloride, extract of Swertia japonica, capsicum tincture, cepharanthin, benzyl nicotinate or garlic extract. The compounding amount of the cytotonic agent or the blood circulation promoting agent is 0.001-10wt.%.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing / hair-growth agent having excellent hair-removing effects such as hair loss prevention and hair growth effect.

[0002]

2. Description of the Related Art Conventionally, baldness and hair loss have been caused by activation of male hormones in organs such as hair roots and sebaceous glands, decrease in blood flow to hair follicles, excessive secretion of sebum, and generation of peroxide in the scalp. Abnormalities etc. are considered. For this reason, conventional hair nourishing and hair-growth agents are blended with components that remove or reduce the above causes.

[0003]

Problems to be Solved by the Invention However, conventional hair-growth and hair-growth agents do not always have sufficient hair-growth effects such as hair loss prevention and hair-growth effects.

[0004]

Means and Actions for Solving the Problems In order to improve the insufficient hair nourishing action as described above, the present inventors have searched for substances having excellent hair loss prevention and hair growth effects. By adding an extract and a cell activating agent or a blood circulation promoting agent, the present inventors have found a hair-growth / hair-growth agent which has excellent hair loss prevention, hair-growth / hair-growth effects, and long-term safety.

That is, the present invention provides a hair nourishing and hair-growing agent characterized by containing an extract of Ganoderma lucidum and a cell activating agent or a blood circulation promoting agent.

[0006] The ginger ginger extract used in the present invention is a geranium family (GERANIACEAE)
nium thunbergii Sieb. et Zucc. After drying the above-ground whole grass of (1), it was cut into a suitable size and extracted with a solvent. As an extraction method, a plant is heated at room temperature or with a solvent, for example, water or a lower alcohol such as methanol or ethanol or a lower alcohol containing water or a polyhydric alcohol such as propylene glycol or 1,3-butylene glycol or a water-containing polyhydric alcohol. Extract under conditions and purify.

An example of the method for producing the ginkgo biloba extract is obtained by adding 3 parts of 50% ethanol to 1 part of a dried garlic ginger extract, extracting at room temperature for 1 week, and then filtering.
Gennoshoko is a plant containing tannins, flavonoids, etc., and is widely used as a gastrointestinal drug. However, it has never been used as a hair restorer / hair restorer. Since the extract of Ginkgo biloba, which is the active ingredient of the hair restorer / hair restorer of the present invention, is not toxic to the human body, the amount to be added to the hair restorer / hair restorer is not particularly limited, but it may be 0.1% by dry weight.
It is preferable to add 001 to 10% by weight. 0.001
If it is less than 10% by weight, the hair-growth and hair-growth effects are not sufficiently exhibited, and if it exceeds 10% by weight, a further hair-growth effect may not be expected, which is not preferable.

The cell activating agent used in the present invention includes:
Pantothenic acid and its derivatives (pantothenyl ethyl ether), Photosensitizer No. 301, carrot extract, biotin,
Examples include mononitroguaiacol, hinokitiol, allantoin, and pentadecanoic acid glyceride. The amount of the cell activating agent added to the hair nourishing / hair-growing agent of the present invention is 0.001-10.
It is preferable to mix by weight%. If the amount is less than 0.001% by weight, sufficient hair-nourishing and hair-growing effects are not exhibited, and if the amount is more than 10% by weight, the scalp has an unpleasant sensation, which is not preferable.

The blood circulation promoter used in the present invention includes:
Carpronium chloride, Assembly extract, Pepper tincture, Cepharanthin, Benzyl nicotinate, Garlic extract, Touki extract, Gentian extract, γ-Oryzanol, Licorice, Minoxidil, Senkyu, Ginseng ginseng, Panax ginseng, Ginger, Jio, Aloe, Spironolactone, Vitamin B ₆ hydrochloride, D-camphor, DL-camphor, DL-α-tocopherol, garlic iodide extract, DL-α-tocopherol linoleate, inositol hexanicotinate, vitamin E, dextran sulfate sodium, nicotinic acid, DL- α-tocopherol nicotinic acid ester,
Butoxyethyl nicotinate, methyl nicotinate, vanillyl amide nonanoate, DL-α-tocopherol succinate, DL-α-tocopherol acetate, cantalis tincture, ginger tincture, and the like, in particular cepharanthin, DL-α-tocopherol, Garlic iodide extract, assembly extract, DL-α-tocopherol nicotinic acid ester, benzyl nicotinate, vanillyl nonanoate, DL-α-tocopherol acetate, capsicum tincture, cantaris tincture, etc. from the viewpoint of hair-feeding effect. preferable. The amount of the blood circulation promoter added to the hair nourishing / hair-growing agent of the present invention is preferably 0.001 to 10% by weight. If the amount is less than 0.001% by weight, sufficient hair-nourishing and hair-growing effects are not exhibited, and if the amount is more than 10% by weight, an unpleasant sensation is given to the scalp, which is not preferable.

In addition to the above-mentioned active ingredients, the hair nourishing and hair-growing agents of the present invention include benzalkonium chloride, salicylic acid, chlorhexidine hydrochloride solution, Photosensitizer 201, chlorhexidine gluconate solution, chlorxylenol, trichlorocarbanilide, and halo. Antibacterial agents such as bactericides such as carban, glycyrrhizin and its derivatives, diphenhydramine hydrochloride, guaizulene, carbenoxolone disodium, shikon extract, ages, 1-menthol, hydrocortisone acetate, prednisolone, sodium hyaluronate, glycerin, sodium pyrrolidone carboxylate, propylene Moisturizers such as glycol, mini sasanishiki extract, chondroitin sulfate, Cordyceps sinensis extract, saffron extract, keratolytic agents such as salicylic acid, resorcin, lactic acid, local stimulants such as peppermint oil, est , Estradiol, ethinyl estradiol and other follicular hormones, pyridoxine and derivatives, sulfur, thioxolone, vancide and other antiseborrheic agents, amino acids, cystine, cysteine, methionine, serine, vitamins and other nutritional supplements it can.

In addition, the hair nourishing and hair-restoring agent of the present invention includes oil (isopropyl myristate, lecithin, squalane, etc.), a surfactant (polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, glycerin fatty acid). Ester, etc.), polyhydric alcohol (propylene glycol, glycerin, macrogol, etc.), antioxidant (dibutylhydroxytoluene, isopropyl gallate, etc.), sequestering agent (ethylenediamine tetraacetate or its salt, etc.), pigment, fragrance, etc. It can be blended appropriately.

The hair nourishing and hair-restoring agent of the present invention is applied several times a day,
An appropriate amount is applied to the scalp and used. In addition, the hair growth of the present invention
The dosage form of the hair restorer is not particularly limited, and conventionally known hair tonics, hair lotions, hair creams, aerosols, ointments and the like can be used.

[0013]

EXAMPLES Next, examples of the present invention will be described, but the present invention is not limited to these examples.

<Hair growth test> C at 7 weeks of age in the resting period
The back hair of 3H mouse (♂) was shaved over 2 × 4 cm ² using an electric clipper and an electric razor. A group of 10 mice was prepared, and 0.1 ml each of the mice was applied to the shaved site once a day. Examples 1 to 3 and Comparative Examples 1 to 4 shown in Table 1.
Of the hair nourishing and hair-growth agent was applied. In order to observe the state of hair regeneration, a photograph of the above shaved site was taken at a fixed magnification, and the ratio of the regenerated hair area (regenerated hair area / shaved area) was calculated using an image analyzer. Table 1 shows the average value of the regenerated hair area ratio (%) of each group on the 14th day after the start of the sample application.

[0015]

[Table 1] As shown in Table 1, as compared with Comparative Example in which the genopsis extract, the cell activating agent or the blood circulation promoting agent was used alone, the hair growth effect was enhanced when the geno ginger extract and the cell activating agent or the blood circulation promoting agent were blended. Was done.

<Practical Test> (Evaluation Method) Examples 1 to 3 and Comparative Examples 1 to 4 shown in Table 1
Using the hair-growth and hair-growth agent, I often lose hair, dandruff,
Ten males (25 to 50 years old) who are concerned about itching were tested for the effect of preventing hair loss, dandruff and itching. The method of use was basically twice a day, in the morning and before bedtime. When the hair was washed, an appropriate amount was applied to the scalp after the hair was washed and massaged. Also, during the test period, they were asked to uniformly use commercially available shampoos and prohibited the use of other rinse agents, tonic agents, hair styling agents, and perms and hair dyes. To determine the effect, hair is washed by a hairdresser once every two weeks, hair that has fallen off during hair washing is collected, the number of hair loss is measured, and the state of the hair root part is observed and classified. The presence and the degree of the occurrence of itch were confirmed by the judgment in the state of time and the consciousness of the person himself. The results were evaluated according to the following criteria, and the results are shown in Table 2.

(Evaluation Criteria) (1) Hair Loss-Effective ... The number of hair loss is decreasing. The hair root is a clean club-shaped normal hair root. Invalid: The number of hair loss has not changed or has increased. Hair roots are abnormal hair roots with atrophy and deformation. (2) Dandruff (visual judgment) ・ Valid… Slightly dandruff-No dandruff is observed. ・ Invalid… Very dandruff is occurring ～ Drunk. (3) Itching (identity) ・ Valid ... Itching that you will forget after a while-You will not feel itching-Invalid ... There is itching that you can not stand-You can endure itching

[0018]

[Table 2]

As shown in Table 2, Examples 1 to 3 of the present invention are shown.
Compared with Comparative Examples 1 to 4, remarkable effects were observed in preventing hair loss, dandruff, and itch.

Furthermore, the hair nourishing and hair-growth agents of Examples 4 to 15 below will be shown.
A remarkable effect was observed in preventing dandruff and itch.

Example 4 Weight part Ethanol 65 Propylene glycol 5 Genoshoko extract 3 Photosensitizer No. 301 0.1 Minoxidil 0.5 DL-α-tocopherol linoleic acid ester 0.1 Purified water Appropriate amount Lotion-type hair growth / hair growth The agent was prepared.

Example 5 Parts by Weight Carboxyvinyl Polymer 0.4 Ethanol 40 Propylene Glycol 1 Glycerin 5 Genus Ginger Extract 2 Carrot Extract 0.2 Assembly Extract 0.2 Diisopropanolamine 0.4 Purified Water Appropriate amount Gel-type hair growth above・ Prepared a hair restorer.

Example 6 parts by weight polyoxyethylene (20) sorbitan monostearate 5 sorbitan monostearate 3 cetanol 2 stearyl alcohol 2 liquid paraffin 10 gem ginger extract 1 vitamin E acetate 0.2 minoxidil 1 pantotenyl ethyl ether 0. 5 Inositol hexanicotinic acid ester 0.1 Methyl paraoxybenzoate 0.1 Propylene glycol 10 Purified water Appropriate amount The above-mentioned cream type hair nourishing / hair-growing agent was prepared.

Example 7 parts by weight Geno ginger extract 4 Hinokitiol 0.5 Cepharanthin 0.5 Benzyl nicotinate 0.3 Ginseng 0.1 Propylene glycol 5 Polyoxyethylene (20) monooleate 5 Ethanol 50 Liquefied petroleum gas 4 Purified water Appropriate amount The above aerosol-type hair nourishing and hair-growing agents were prepared.

Example 8 parts by weight Carboxyvinyl polymer 0.4 Ethanol 40 Propylene glycol 5 Diisopropanolamine 0.4 Genus ginger extract 1 Biotin 0.5 Capsicum tincture 0.3 Cepharanthin 0.3 Vitamin E 0.1 Nicotinic acid 0 .1 Purified water Appropriate amount The above gel-type hair nourishing / hair-growing agent was prepared.

Example 9 parts by weight Geno ginger extract 2 mononitroguaiacol 1 benzyl nicotinate 0.5 garlic extract 0.1 1,3-butanediol 2 propylene glycol 4 polyoxyethylene (20) polyoxypropylene (6) decyl Tetradecyl ether 3 Ethanol 55 Purified water Appropriate amount The above lotion type hair nourishing and hair-growing agents were prepared.

Example 10 parts by weight Geno ginger extract 3 Allantoin 0.2 Touki extract 0.1 Spironolactone 0.1 Gentiana extract 0.1 Glycyrrhetinic acid 0.2 Glyceryl monoisostearate 1 Propylene glycol 5 Polyoxyethylene (20) Sorbitan mono oleate 1.5 Ethanol 70 Purified water Appropriate amount The above lotion-type hair nourishing / hair-growing agent was prepared.

Example 11 parts by weight Genzo ginger extract 5 pentadecanoic acid glyceride 0.1 γ-oryzanol 0.1 licorice 0.2 butoxyethyl nicotinate 0.1 ethanol 65 propylene glycol 5 purified water suitable amount lotion-type hair nourishing / A hair restorer was prepared.

Example 12 parts by weight Geno ginger extract 1 Senkyu 0.1 Chixetsu ginseng 0.1 Ginger 0.1 Dioe 0.1 Aloe 0.5 Carboxyvinyl polymer 0.4 Ethanol 40 Propylene glycol 1 Glycerin 5 Diisopropanolamine 0.4 Purified water Appropriate amount The above gel-type hair nourishing / hair-growing agent was prepared.

Example 13 parts by weight Genzo ginger extract 2 Vitamin B ₆ hydrochloride 0.1 DL-camphor 0.2 DL-α-tocopherol 0.2 methyl nicotinate 0.1 polyoxyethylene (20) sorbitan monostearate 5 Sorbitan monostearate 3 Cetanol 2 Stearyl alcohol 2 Liquid paraffin 10 Methyl paraoxybenzoate 0.1 Propylene glycol 10 Purified water Appropriate amount The above cream-type hair-growth and hair-growth agents were prepared.

Example 14 parts by weight Genus ginseng extract 0.5 nonanoic acid vanillyl amide 0.1 succinic acid DL-α-tocopherol 0.1 DL-α-tocopherol acetate 0.2 capsicum tincture 0.1 cantharisin tincture 0.1 1,3-Butanediol 5 Polyoxyethylene (60) hydrogenated castor oil 0.4 Octyldodecyl myristate 1 Glyceryl monoisostearate 1 Ethanol 65 Purified water Appropriate amount The above lotion-type hair-growth and hair-growth agents were prepared.

Example 15 parts by weight Geno ginger extract 7 Garlic iodide extract 0.1 DL-α-tocopherol nicotinate 0.1 Ginger tincture 0.2 D-camphor 0.1 dextran sodium sulfate, 0.5 Propylene Glycol 5 Polyoxyethylene (20) monooleate 5 Ethanol 50 Liquefied petroleum gas 4 The above aerosol-type hair restorer and hair restorer was prepared.

[0033]

EFFECTS OF THE INVENTION A hair nourishing and hair-growth agent having excellent long-term safety and hair loss-preventing effect, hair nourishment, and hair nourishing effect, which are excellent in anti-hair loss and hair nourishment, is provided by blending an extract of Ginkgo biloba and a cell activating agent or a blood circulation promoter. be able to.

Claims (3)

[Claims] 1. A hair nourishing and hair-growing agent, which comprises one or two or more kinds of genoderma lucidum extract and a cell activating agent or blood circulation promoting agent. 2. An extract of Genticho mori extract 0.001-1
The hair nourishing agent according to claim 1, wherein the hair nourishing agent is contained in an amount of 0% by weight. 3. A cell activating agent or a blood circulation promoting agent is added in an amount of 0.001.
10. The hair nourishing / hair-growth agent according to claim 1, wherein the hair nourishing / hair-growth agent is contained in an amount of 10 to 10 wt%.